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Shuqiu Chen, Guiya Jiang, Ning Liu, Hua Jiang, Lijie Zhang, Chao Sun, Bin Xu, Xiaowen Zhang, Yu Yang, Jing Liu, Weidong Zhu, Ming Chen
PURPOSE: We discuss the safety and perioperative outcomes of a 2-week interval between prostate biopsy and laparoscopic radical prostatectomy (LRP). MATERIALS AND METHODS: We retrospectively reviewed the medical records of 182 patients with prostate cancer (PCa) who underwent transperitoneal LRP 2 weeks after prostate biopsy between 2012 and 2015. We evaluated the following perioperative outcomes: operative time, estimated blood loss (EBL), infection, conversion to open surgery, positive surgery margins (PSM), and complications...
July 14, 2018: Urology Journal
Katherine M Richards, Rebecca A Spicer, Elizabeth Craig, Sean E Kennedy
BACKGROUND: Blood transfusion after kidney transplant carries a risk of sensitization to the graft as well as blood borne infections. The aim of this study was to describe the prevalence of blood transfusions in pediatric recipients of kidney transplants and to determine the factors associated with transfusions during the perioperative period. Additionally, to describe the changes in hemoglobin levels during the first 12 months following transplant. METHOD: A retrospective, single center analysis using data collected prospectively between 2010 and 2017...
July 13, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Michaela Kohlová, Célia Gomes Amorim, Alberto Araújo, Alice Santos-Silva, Petr Solich, Maria Conceição B S M Montenegro
End-stage renal disease is a growing health problem with increasing prevalence and high health care costs. Patients suffering from end-stage renal disease exhibit higher morbidity and mortality rates compared to the general population. These patients, who are treated using hemodialysis, typically suffer from anemia, inflammation, and oxidative stress. Inadequate dialyzer membrane biocompatibility exacerbates these negative side effects. Modifications of the composition of hemodialysis membranes have improved their biocompatibility and improve the patients' quality of life...
July 14, 2018: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
Simon Berhe, Matthew M Heeney, Dean R Campagna, John F Thompson, Eric J White, Tristen Ross, Roy Wa Peake, Jeffery D Hanrahan, Vilmarie Rodriguez, Deborah L Renaud, Mrinal S Patnaik, Eugenia Chang, Sylvia S Bottomley, Mark D Fleming
No abstract text is available yet for this article.
July 13, 2018: Haematologica
Camila Masias, Spero R Cataland
ADAMTS13 (A Disintegrin And Metalloproteinase with Thrombospondin type 1 motif, 13) is a metalloprotease responsible for cleavage of ultra large Von Willebrand factor (ULVWF) multimers. Severely deficient activity of the protease can trigger an acute episode of thrombotic thrombocytopenic purpura (TTP). Our understanding of the pathophysiology of TTP, has allowed us to grasp the important role of ADAMTS13 in other thrombotic microangiopathies (TMA) and thrombotic disorders, such as ischemic stroke and coronary artery disease...
July 13, 2018: Blood
Kuo-Ming Yu, Johnson Yiu-Nam Lau, Manson Fok, Yuk-Keung Yeung, Siu-Ping Fok, Tsan-Lin Hu, Yuan-Jang Tsai, Qui-Lim Choo
Treating thrombocytopenia induced by chemotherapy remains an unmet-medical need. The use of recombinant human interleukin-11 (rhIL-11) requires repeated injections and induces significant fluid retention in some patients. Modification of human interleukin-11 with chemically inert polyethylene glycol polymer (PEG) may extend the peripheral circulation half-life leading to an improved pharmacokinetic and pharmadynamic profile. In this study, a number of rhIL-11 PEG conjugates were created to determine the optimal approach to prolong circulating half-life with the most robust pharmacological effect...
July 10, 2018: Journal of Pharmaceutical Sciences
Talya Miller, David L Suskind
PURPOSE OF REVIEW: Nutritional interventions play a central role in the treatment and management of inflammatory bowel disease (IBD) in children. Although malnutrition is a common presenting sign of IBD, nutritional interventions have focused not only on correction of the malnourished state but also on treatment of the primary disease. RECENT FINDINGS: Exclusive enteral nutrition (EEN) has been the primary therapy utilized in pediatric IBD specifically, Crohn's disease...
July 12, 2018: Current Opinion in Pediatrics
Dazhou Xu, Xinjian Fang, Yi Li, Zhimei Zhang, Qiuling Li
PURPOSE: To demonstrate the potential significance of perioperative blood transfusion on the prognosis of gastric cancer. METHODS: Data from 234 patients who were subjected to radical gastrectomy in our hospital were obtained and retrospectively analyzed. Patients' age, gender, preoperative anemia, tumor size, location, invasion depth, lymph node metastasis, TNM stage, presence or absence of blood transfusion and blood transfusion volume were observed and analyzed...
May 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
Harm Wienbergen, Otmar Pfister, Matthias Hochadel, Andreas Fach, Tina Backhaus, Oliver Bruder, Björn Andrew Remppis, Micha Tobias Maeder, Wolfgang von Scheidt, Matthias Pauschinger, Jochen Senges, Rainer Hambrecht
INTRODUCTION: Iron deficiency (ID) has been recognized as a relevant comorbidity in heart failure with reduced ejection fraction (HFrEF); however, study data have shown that diagnostic and therapeutic efforts on ID are primarily performed in patients with anemia. METHODS: The RAID-HF registry investigated consecutive patients with ID and HFrEF in 11 heart centers in Germany and Switzerland. The present analysis focuses on 1-year follow-up data in patients with versus without anemia...
July 12, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
Raymond D Pratt, Sarah Grimberg, Joshua J Zaritsky, Bradley A Warady
BACKGROUND: Iron deficiency is a common cause of anemia in pediatric patients with hemodialysis-dependent chronic kidney disease (CKD-5HD). Ferric pyrophosphate citrate (FPC, Triferic®) donates iron directly to transferrin, bypassing the reticuloendothelial system and avoiding iron sequestration. Administration of FPC via dialysate or intravenously (IV) may provide a suitable therapeutic option to current IV iron preparations for these patients. METHODS: The pharmacokinetics and safety of FPC administered via dialysate and IV to patients aged < 6 years (n = 3), 6 to < 12 years (n = 4), and 12 to <18 years (n = 15) were investigated in a multicenter, open-label, two-period, single-dose study...
July 12, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Angesom Gebreweld, Delayehu Bekele, Aster Tsegaye
Background: In pregnancy, hematological changes occur in order to meet the demands of the developing fetus and placenta, with major alterations in blood volume. Abnormal hematological profile affects pregnancy and its outcome. This study aimed to assess hematological profiles of pregnant women at a tertiary care teaching hospital. Method: This cross sectional study was conducted among 284 consecutive pregnant women at St. Paul's Hospital Millennium Medical College...
2018: BMC Hematology
Arif Emre, Sami Akbulut, Mehmet Sertkaya, Muharrem Bitiren, Ilhami Taner Kale, Ertan Bulbuloglu
Introduction: The most important risk factors for colorectal cancer are age, high ASA score, anemia, low albumin, tumor stage, histopathological properties, tumor's relationship with adjacent tissues, positivity of surgical borders and timing of the surgical procedure. Aim: To determine possible risk factors for mortality in patients undergoing colorectal cancer surgery. Material and methods: The medical records of 101 consecutive patients who underwent colorectal cancer surgery at the Department of Surgery, Sutcu Imam University Faculty of Medicine, Kahramanmaras, Turkey between January 2008 and November 2015 were retrospectively reviewed...
2018: Przegla̜d Gastroenterologiczny
Eungyoung Kim, Jehyun Nam, Woochul Chang, Ismayil S Zulfugarov, Zhanna M Okhlopkova, Daniil Olennikov, Nadezhda K Chirikova, Sang-Woo Kim
Angelica gigas Nakai (AGN) is an oriental traditional medicine to treat anemia, dysmenorrhea, and migraine. However, its anti-lymphoma effect is yet to be tested. Here, we demonstrated that AGN and its major component decursin target Myc to suppress lymphomagenesis in vitro and in vivo. AGN inhibited cell viability in multiple B lymphoma cells, while sparing normal splenocytes and bone marrow cells. Increased cleaved PARP level and caspase 3/7 activity and the repression of survival-promoting AKT/mTOR and MAPK pathways downstream of BCR, were responsible for the pro-apoptotic effects of AGN...
July 12, 2018: Scientific Reports
Javier Alberto Rojas-Martínez, Rosario M Morales-Camacho
No abstract text is available yet for this article.
July 12, 2018: Blood
Felipe Imigo G, María-Elena Molina P, Manuel Álvarez-Lobos, Carlos Quintana V, Julieta Klaassen L, Javiera Torres M, Ignacio Duarte G, Felipe Bellolio R, Álvaro Zúñiga D
BACKGROUND: Exclusive involvement of the colon or rectum in Crohn's disease, called Crohn's colitis, (CC) occurs in about 25% of these patients. AIM: To analyze early surgical results and long-term outcomes of patients undergoing surgery for CC. MATERIAL AND METHODS: Review of a prospective database, identifying patients with Crohn's disease operated between 2003 and 2015 and excluding those with ileocecal disease. We analyzed demographic data, pre and postoperative pharmacological treatment, operations, morbidity and the need for a second bowel resection at follow-up...
February 2018: Revista Médica de Chile
Pilar León, Daniela Cardemil, Rocío Osorio, Camila Peña, Ximena Valladares, Bárbara Puga, María Elena Cabrera
BACKGROUND: The first line treatment for patients < 40 years old with aplastic anemia (AA) is allogeneic HLA-identical sibling donor transplantation (SCT). Immunosuppressive therapy (IST) with a combination of Thymoglobuline (ATG) and cyclosporine is used for older patients or those without a donor. Five year overall survival (OS) for both therapies is > 70%. AIM: To report the experience with SCT and ATG for AA in a public hospital. PATIENTS AND METHODS: AA was diagnosed in 42 patients between 1998 and 2016, according to Camitta criteria...
February 2018: Revista Médica de Chile
María Paz Muñoz, Álvaro Vega, Daniela Lecaros, Francisco Saitua
INTRODUCTION: Capsule endoscopy (CE) is a non-invasive technique that allows visualization of small intestine mucosa. It is used for diagnosis of lesions not accessible with other tests. Our goal was to describe the experience using CE in a pediatric public hospital in Chile. PATIENTS AND METHOD: A retrospective study was carried out to review the cases in which CE was used at Dr. Luis Calvo Mac- kenna Hospital from 2010 to date. Demographic and clinical data, findings, complications, diagnosis and treatment were recorded...
June 2018: Revista Chilena de Pediatría
Pilar León, Josefina Lería, Daniela Cardemil, Angélica Díaz, Miguelina Hernández, Magdalena Chubretovic, Josefa González, María Elena Cabrera
Aplastic anemia (AA) or acquired aplastic anemia is an uncommon and potentially fatal disease. It is defined as reduction of at least two peripheral blood series, associated with persistent bone marrow hypocellularity. It's association with pregnancy is even more uncommon, and it may result in high mortality for the mother and the child. We report an adolescent female with aplastic anemia, which worsened during pregnancy. Her hemoglobin was 5.2 g/dl, her leukocytes were 1,833/ul and her platelets were 19,000/ul...
March 2018: Revista Médica de Chile
Hideto Iwafuchi
Bone marrow failure (BMF) is a rare but life-threatening disorder that usually manifests as (pan)cytopenia. BMF can be caused by a variety of diseases, but inherited BMF (IBMF) syndromes are a clinically important cause, especially in children. IBMF syndromes are a heterogeneous group of genetic disorders characterized by BMF, physical abnormalities, and predisposition to malignancy. An accurate diagnosis is critical, as disease-specific management, surveillance, and genetic counselling are required for each patient...
2018: Journal of Clinical and Experimental Hematopathology: JCEH
Kuniaki Ota, Toshifumi Takahashi, Satoru Shiraishi, Hideki Mizunuma
AIM: Menorrhagia and dysmenorrhea are common symptoms. Uterine adenomyosis is one of the causes of menorrhagia and dysmenorrhea. These symptoms often decrease the quality of life in women. Microwave endometrial ablation (MEA) is a recently developed procedure that enables endometrial ablation. Dienogest has long been used to suppress endometrium development and reduce adenomyosis-related dysmenorrhea. However, some cases could be resistant to dienogest. In this study, we evaluated the efficacy of a combination of MEA and postoperative dienogest in reducing adenomyosis-related dysmenorrhea and menorrhagia...
July 12, 2018: Journal of Obstetrics and Gynaecology Research
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