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Biodegradable scaffold

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https://www.readbyqxmd.com/read/28747594/mechanical-and-biological-effects-of-infiltration-with-biopolymers-on-3d-printed-tricalciumphosphate-scaffolds
#1
Matthias Cornelsen, Florian Andreas Probst, Christina Schwarz, Egon Burian, Matthias Tröltzsch, Sven Otto, Maximilian Michael Saller, Matthias Schieker, Hermann Seitz
The aim of this study was to evaluate the influence of infiltrating 3D printed (TCP) scaffolds with different biodegradable polymers on their mechanical and biological properties. 3D printed TCP scaffolds with interconnecting channels measuring 450±50 µm were infiltrated with four different biodegradable copolymers. To determine the average compressive strength, a uniaxial testing system was used. Additionally, scaffolds were seeded with MC3T3 cells and cell viability was assessed by live/dead-assay. Uninfiltrated TCP had an average compression strength of 1...
July 26, 2017: Dental Materials Journal
https://www.readbyqxmd.com/read/28744124/fast-degrading-pla-ormoglass-fibrous-composite-scaffold-leads-to-a-calcium-rich-angiogenic-environment
#2
Nadège Sachot, Agata Roguska, Josep Anton Planell, Malgorzata Lewandowska, Elisabeth Engel, Oscar Castaño
The success of scaffold implantation in acellular tissue engineering approaches relies on the ability of the material to interact properly with the biological environment. This behavior mainly depends on the design of the graft surface and, more precisely, on its capacity to biodegrade in a well-defined manner (nature of ions released, surface-to-volume ratio, dissolution profile of this release, rate of material resorption, and preservation of mechanical properties). The assessment of the biological behavior of temporary templates is therefore very important in tissue engineering, especially for composites, which usually exhibit complicated degradation behavior...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28730531/comparing-different-tissue-engineered-repair-materials-for-the-treatment-of-pelvic-organ-prolapse-and-urinary-incontinence-which-material-is-better
#3
Xiaojuan Wang, Yisong Chen, Zhongyong Fan, Keqin Hua
INTRODUCTION AND HYPOTHESIS: Synthetic non-absorbable meshes are widely used to augment surgical repair of pelvic organ prolapse (POP) and stress urinary incontinence (SUI), but these meshes are associated with serious complications. This study compares the attachment and extracellular matrix (ECM) production of adipose-derived stem cells (ADSCs) on different biodegradable nanomaterials to develop tissue engineered repair materials. METHODS: Rat ADSCs were isolated and cultured on electrospun poly-L-lactic acid (PLA) and electrospun poly(L-lactide)-trimethylene carbonate-gycolide (PLTG) terpolymers for 1 and 2 weeks...
July 20, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28725934/-scaffold-based-bone-tissue-engineering
#4
REVIEW
B M Holzapfel, M Rudert, D W Hutmacher
Tissue engineering provides the possibility of regenerating damaged or lost osseous structures without the need for permanent implants. Within this context, biodegradable and bioresorbable scaffolds can provide structural and biomechanical stability until the body's own tissue can take over their function. Additive biomanufacturing makes it possible to design the scaffold's architectural characteristics to specifically guide tissue formation and regeneration. Its nano-, micro-, and macro-architectural properties can be tailored to ensure vascularization, oxygenation, nutrient supply, waste exchange, and eventually ossification not only in its periphery but also in its center, which is not in direct contact with osteogenic elements of the surrounding healthy tissue...
July 19, 2017: Der Orthopäde
https://www.readbyqxmd.com/read/28720867/graphene-microfiber-as-a-scaffold-for-regulation-of-neural-stem-cells-differentiation
#5
Weibo Guo, Jichuan Qiu, Jingquan Liu, Hong Liu
We report the cytocompatibility and regulating effects of the nanostructured reduced graphene oxide (rGO) microfibers, which are synthesized through a capillary hydrothermal method, on neural differentiation of neural stem cells (NSCs). Our findings indicate that the flexible, mechanically strong, surface nanoporous, biodegradable, and cytocompatible nanostructured rGO microfibers not only offer a more powerful substrate for NSCs adhesion and proliferation compared with 2D graphene film and tissue cluture plate but also regulate the NSCs differentiation into neurons and form a dense neural network surrounding the microfiber...
July 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28719343/preparation-and-properties-of-polyvinyl-alcohol-pva-and-hydroxylapatite-ha-hydrogels-for-cartilage-tissue-engineering
#6
F Yuan, M Ma, L Lu, Z Pan, W Zhou, J Cai, S Luo, W Zeng, F Yin
A novel bioactive hydrogel for cartilage tissue based on polyvinyl alcohol (PVA) and hydroxylapatite (HA) were prepared, the effects of its component contents on the mechanical properties and microstructure of the hydrogel were investigated. The important properties of the scaffold composites, such as density, porosity, compressive modulus and microstructure were studied and analyzed through various measurements and methods. The biodegradability of hydrogel was evaluated by soaking the samples into artificial degradation solution at body temperature (36 - 37 oC) in vitro...
May 20, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28716610/current-status-and-future-direction-of-biodegradable-metallic-and-polymeric-vascular-scaffolds-for-next-generation-stents
#7
REVIEW
Seung Hyuk Im, Youngmee Jung, Soo Hyun Kim
Because of the increasing incidence of coronary artery disease, the importance of cardiovascular stents has continuously increased as a treatment of this disease. Biodegradable scaffolds fabricated from polymers and metals have emerged as promising materials for vascular stents because of their biodegradability. Although such stent framework materials have shown good clinical efficacy, it is difficult to decide whether polymers or metals are better vascular scaffolds because their properties are different. Therefore, there are still obstacles in the development of biodegradable vascular scaffolds in terms of improving clinical efficacy...
July 14, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28715970/scaffold-in-scaffold-potential-to-induce-growth-and-differentiation-of-cardiac-progenitor-cells
#8
Matteo Ciocci, Federico Mochi, Felicia Carotenuto, Emilia Di Giovanni, Paolo Prosposito, Roberto Francini, Fabio De Matteis, Igor Reshetov, Mauro Casalboni, Sonia Melino, Paolo Di Nardo
The design of reliable biocompatible and biodegradable scaffolds remains one of the most important challenges for tissue engineering. In fact, properly designed scaffolds must display an adequate and interconnected porosity to facilitate cell spreading and colonization of the inner layers, and must release physical signals concurring to modulate cell function to ultimately drive cell fate. In the present study, a combination of optimal mechanical and biochemical properties has been considered to design a one-component 3D multitextured hydrogel scaffold in order to favor cell-scaffold interactions...
July 17, 2017: Stem Cells and Development
https://www.readbyqxmd.com/read/28715113/calcium-deposition-in-photocrosslinked-poly-pro-hyp-gly-hydrogels-encapsulated-rat-bone-marrow-stromal-cells
#9
Farah Nurlidar, Keisuke Yamane, Mime Kobayashi, Kayo Terada, Tsuyoshi Ando, Masao Tanihara
Reproducing the features of the extracellular matrix is important for fabricating three-dimensional (3D) scaffolds for tissue regeneration. A collagen-like polypeptide, poly(Pro-Hyp-Gly), is a promising material for 3D scaffolds because of its excellent physical properties, biocompatibility, and biodegradability. In this paper, we present a novel photocrosslinked poly(Pro-Hyp-Gly) hydrogel as a 3D scaffold for simultaneous rat bone marrow stromal cell (rBMSC) encapsulation. The hydrogels were fabricated using visible-light photocrosslinking at various concentrations of methacrylated poly(Pro-Hyp-Gly) (20-50 mg/mL) and irradiation times (3 or 5 min)...
July 17, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28714408/biomaterials-and-supercritical-fluid-technologies-which-perspectives-to-fabricate-artificial-extracellular-matrix
#10
Della Porta Giovanna, E Reverchon, N Maffulli
The foundation of tissue engineering for either therapeutic or diagnostic applications is the ability to exploit living cells. Tissue engineering utilizes living cells as engineering materials implanted, seeded or bio-plotted into an artificial structure capable of supporting three-dimensional tissue formation. These structures, typically called scaffolds, are critical, both ex vivo and in vivo, to influence their own microenvironments. Scaffolds can serve the following purposes: allow cell attachment and migration, deliver and retain cells and biochemical factors, enable diffusion of vital cell nutrients or expressed products, exert certain mechanical and biological influences to modify the behaviour of the cell phase...
July 13, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28714236/effectiveness-of-tissue-engineered-three-dimensional-bioactive-graft-on-bone-healing-and-regeneration-an-in-vivo-study-with-significant-clinical-value
#11
Mostafa Shahrezaie, Ali Moshiri, Babak Shekarchi, Ahmad Oryan, Nicola Maffulli, Javad Parvizi
Several strategies have been used to promote bone repair; with many failing due to the lack of osteoinduction. We describe our approach for promoting bone healing that attempts to overcome prior shortcomings. First, we compared the role of different concentrations of Gelatin (Gel), nanostructured-hydroxyapatite (nHA), Simvastatin (Sim) and nHA-Sim particles on healing of small femoral bone defects in rabbits. The effective concentration of each of them was studied, and then a three-dimensional porous scaffold was designed using Gel, nHA and Sim which was then cross-linked with Genipin...
July 17, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28707508/design-and-fabrication-of-porous-biodegradable-scaffolds-a-strategy-for-tissue-engineering
#12
Vahideh Raeisdasteh Hokmabad, Soodabeh Davaran, Ali Ramazani, Roya Salehi
Current strategies of tissue engineering are focused on the reconstruction and regeneration of damaged or deformed tissues by grafting of cells with scaffolds and biomolecules. Recently, much interest is given to scaffolds which are based on mimic the extracellular matrix that have induced the formation of new tissues. To return functionality of the organ, the presence of a scaffold is essential as a matrix for cell colonization, migration, growth, differentiation and extracellular matrix deposition, until the tissues are totally restored or regenerated...
July 14, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28702219/modification-and-optimization-of-electrospun-gelatin-sheets-by-electron-beam-irradiation-for-soft-tissue-engineering
#13
Jae Baek Lee, Young-Gwang Ko, Donghwan Cho, Won Ho Park, Oh Hyeong Kwon
BACKGROUND: Crosslinked gelatin nanofibers are one of the widely used scaffolds for soft tissue engineering. However, modifying the biodegradation rate of chemically crosslinked gelatin is necessary to facilitate cell migration and tissue regeneration. Here, we investigated the optimal electron beam (e-beam) irradiation doses with biodegradation behavior on changes in the molecular weight, morphology, pore structure, and cell proliferation profiles of electrospun nanofibrous gelatin sheets...
2017: Biomaterials Research
https://www.readbyqxmd.com/read/28701742/tissue-engineered-trachea-from-a-3d-printed-scaffold-enhances-whole-segment-tracheal-repair
#14
Manchen Gao, Hengyi Zhang, Wei Dong, Jie Bai, Botao Gao, Dekai Xia, Bei Feng, Maolin Chen, Xiaomin He, Meng Yin, Zhiwei Xu, Nevin Witman, Wei Fu, Jinghao Zheng
Long segmental repair of trachea stenosis is an intractable condition in the clinic. The reconstruction of an artificial substitute by tissue engineering is a promising approach to solve this unmet clinical need. 3D printing technology provides an infinite possibility for engineering a trachea. Here, we 3D printed a biodegradable reticular polycaprolactone (PCL) scaffold with similar morphology to the whole segment of rabbits' native trachea. The 3D-printed scaffold was suspended in culture with chondrocytes for 2 (Group I) or 4 (Group II) weeks, respectively...
July 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28699281/promoting-cell-migration-in-tissue-engineering-scaffolds-with-graded-channels
#15
Degang Yang, Zhitong Zhao, Fan Bai, Shutao Wang, Antoni P Tomsia, Hao Bai
Ideal bone scaffolds having good biocompatibility, good biodegradability, and beneficial mechanical properties are the basis for bone tissue engineering. Specifically, cell migration within 3D scaffolds is crucial for bone regeneration of critical size defects. In this research, hydroxyapatite scaffolds with three different types of architectures (tortuous, parallel, and graded channels) are fabricated using the freeze-casting (ice-templating) method. While most studies promote cell migration by chemical factors, it can be greatly enhanced by introducing only graded channels as compared with tortuous or parallel channels...
July 12, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28698817/the-fabrication-of-biomimetic-biphasic-can-pac-hydrogel-with-a-seamless-interfacial-layer-applied-in-osteochondral-defect-repair
#16
Jinfeng Liao, Taoran Tian, Sirong Shi, Xueping Xie, Quanquan Ma, Guo Li, Yunfeng Lin
Cartilage tissue engineering based on biomimetic scaffolds has become a rapidly developing strategy for repairing cartilage defects. In this study, a biphasic CAN-PAC hydrogel for osteochondral defect (OCD) regeneration was fabricated based on the density difference between the two layers via a thermally reactive, rapid cross-linking method. The upper hydrogel was cross-linked by CSMA and NIPAm, and the lower hydrogel was composed of PECDA, AAm and PEGDA. The interface between the two layers was first grafted by the physical cross-linking of calcium gluconate and alginate, followed by the chemical cross-linking of the carbon-carbon double bonds in the other components...
2017: Bone Research
https://www.readbyqxmd.com/read/28697631/recent-advances-on-biomedical-applications-of-scaffolds-in-wound-healing-and-dermal-tissue-engineering
#17
Azizeh Rahmani Del Bakhshayesh, Nasim Annabi, Rovshan Khalilov, Abolfazl Akbarzadeh, Mohammad Samiei, Effat Alizadeh, Mohammadreza Alizadeh-Ghodsi, Soodabeh Davaran, Azadeh Montaseri
The tissue engineering field has developed in response to the shortcomings related to the replacement of the tissues lost to disease or trauma: donor tissue rejection, chronic inflammation and donor tissue shortages. The driving force behind the tissue engineering is to avoid the mentioned issues by creating the biological substitutes capable of replacing the damaged tissue. This is done by combining the scaffolds, cells and signals in order to create the living, physiological, three-dimensional tissues. A wide variety of skin substitutes are used in the treatment of full-thickness injuries...
July 12, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28697435/comparative-analysis-of-poly-glycolic-acid-based-hybrid-polymer-starter-matrices-for-in-vitro-tissue-engineering
#18
Melanie Generali, Debora Kehl, Andrew K Capulli, Kevin K Parker, Simon P Hoerstrup, Benedikt Weber
Biodegradable scaffold matrixes form the basis of any in vitro tissue engineering approach by acting as a temporary matrix for cell proliferation and extracellular matrix deposition until the scaffold is replaced by neo-tissue. In this context several synthetic polymers have been investigated, however a concise systematic comparative analyses is missing. Therefore, the present study systematically compares three frequently used polymers for the in vitro engineering of extracellular matrix based on poly-glycolic acid (PGA) under static as well as dynamic conditions...
July 1, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28694238/functionalized-bioengineered-spider-silk-spheres-improve-nuclease-resistance-and-activity-of-oligonucleotide-therapeutics-providing-a-strategy-for-cancer-treatment
#19
Anna Karolina Kozlowska, Anna Florczak, Maciej Smialek, Ewelina Dondajewska, Andrzej Mackiewicz, Marcin Kortylewski, Hanna Dams-Kozlowska
Cell-selective delivery and sensitivity to serum nucleases remain major hurdles to the clinical application of RNA-based oligonucleotide therapeutics, such as siRNA. Spider silk shows great potential as a biomaterial due to its biocompatibility and biodegradability. Self-assembling properties of silk proteins allow for processing into several different morphologies such as fibers, scaffolds, films, hydrogels, capsules and spheres. Moreover, bioengineering of spider silk protein sequences can functionalize silk by adding peptide moieties with specific features including binding or cell recognition domains...
July 8, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28691869/composite-electrospun-nanofibers-of-reduced-graphene-oxide-grafted-with-poly-3-dodecylthiophene-and-poly-3-thiophene-ethanol-and-blended-with-polycaprolactone
#20
Raana Sarvari, Somaye Sattari, Bakhshali Massoumi, Samira Agbolaghi, Younes Beygi-Khosrowshahi, Amir Kahaie-Khosrowshahi
In this paper, an effective method was employed for preparation of nanofibers using conducting polymer-functionalized reduced graphene oxide (rGO). First, graphene oxide (GO) was obtained from graphite by Hommer method. GO was reduced to rGO by NaBH4 and covalently functionalized with a 3-thiophene acetic acid (TAA) by an esterification reaction to reach 3-thiophene acetic acid-functionalized reduced graphene oxide macromonomer (rGO-f-TAAM). Afterward, rGO-f-TAAM was copolymerized with 3-dodecylthiophene (3DDT) and 3-thiophene ethanol (3TEt) to yield rGO-f-TAA-co-PDDT (rGO-g-PDDT) and rGO-f-TAA-co-P3TEt (rGO-g-PTEt), which were confirmed by Fourier transform infrared spectra...
July 20, 2017: Journal of Biomaterials Science. Polymer Edition
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