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Biodegradable scaffold

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https://www.readbyqxmd.com/read/29243907/strategy-of-metal-polymer-composite-stent-to-accelerate-biodegradation-of-iron-based-biomaterials
#1
Yongli Qi, Haiping Qi, Yao He, Wenjiao Lin, Pei-Ze Li, Li Qin, Yiwen Hu, Liping Chen, Qingsong Liu, Hongtao Sun, Qiong Liu, Gui Zhang, Shuquan Cui, Jun Hu, Lin Yu, Deyuan Zhang, Jiandong Ding
The new principle and technique to tune biodegradation rates of biomaterials is one of keys to development of regenerative medicine and next-generation biomaterials. Biodegradable stents are new-generation medical devices applied in percutaneous coronary intervention etc. Recently, both corrodible metals and degradable polymers have drawn much attention in biodegradable stents or scaffolds. It is, however, a dilemma to achieve good mechanical properties and appropriate degradation profiles. Herein, we put forward a metal-polymer composite strategy to achieve both...
December 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29242158/additively-manufactured-biodegradable-porous-magnesium
#2
Y Li, J Zhou, P Pavanram, M A Leeflang, L I Fockaert, B Pouran, N Tümer, K-U Schröder, J M C Mol, H Weinans, H Jahr, A A Zadpoor
An ideal bone substituting material should be bone-mimicking in terms of mechanical properties, present a precisely controlled and fully interconnected porous structure, and degrade in the human body to allow for full regeneration of large bony defects. However, simultaneously satisfying all these three requirements has so far been highly challenging. Here we present topologically ordered porous magnesium (WE43) scaffolds based on the diamond unit cell that were fabricated by selective laser melting (SLM) and satisfy all the requirements...
December 11, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29241325/nanoscale-organic-inorganic-hybrid-photosensitizer-for-highly-effective-photodynamic-cancer-therapy
#3
Jia Chen, Yu Xu, Yu Gao, Dongliang Yang, Fei Wang, Lei Zhang, Biqing Bao, Lianhui Wang
Recently, photodynamic therapy (PDT) has attracted significant attention as a minimally invasive approach for cancer treatment. Clinical applications of current photosensitizers are often limited by their poor water solubility, low singlet oxygen (1O2) quantum yields, long-term toxicity, instability and complex nanostructures. Here we report a rational design of polyhedral oligomeric silsesquioxanes (POSS)-based porphyrin (PPP5000) used as intrinsically nanoscale photosensitizer. In this strategy, inorganic 3D rigid block POSS not only act as anti-aggregate units but also provide conjugating reactive sites for further chemical modification...
December 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29236117/liquid-crystal-elastomer-foams-with-elastic-properties-specifically-engineered-as-biodegradable-brain-tissue-scaffolds
#4
M E Prévôt, H Andro, S L M Alexander, S Ustunel, C Zhu, Z Nikolov, S T Rafferty, M T Brannum, B Kinsel, L T J Korley, E J Freeman, J A McDonough, R J Clements, E Hegmann
Tissue regeneration requires 3-dimensional (3D) smart materials as scaffolds to promote transport of nutrients. To mimic mechanical properties of extracellular matrices, biocompatible polymers have been widely studied and a diverse range of 3D scaffolds have been produced. We propose the use of responsive polymeric materials to create dynamic substrates for cell culture, which goes beyond designing only a physical static 3D scaffold. Here, we demonstrated that lactone- and lactide-based star block-copolymers (SBCs), where a liquid crystal (LC) moiety has been attached as a side-group, can be crosslinked to obtain Liquid Crystal Elastomers (LCEs) with a porous architecture using a salt-leaching method to promote cell infiltration...
December 13, 2017: Soft Matter
https://www.readbyqxmd.com/read/29231857/biodegradable-scaffolds-for-bone-regeneration-combined-with-drug-delivery-systems-in-osteomyelitis-therapy
#5
REVIEW
Rossella Dorati, Antonella DeTrizio, Tiziana Modena, Bice Conti, Francesco Benazzo, Giulia Gastaldi, Ida Genta
A great deal of research is ongoing in the area of tissue engineering (TE) for bone regeneration. A possible improvement in restoring damaged tissues involves the loading of drugs such as proteins, genes, growth factors, antibiotics, and anti-inflammatory drugs into scaffolds for tissue regeneration. This mini-review is focused on the combination of the local delivery of antibiotic agents with bone regenerative therapy for the treatment of a severe bone infection such as osteomyelitis. The review includes a brief explanation of scaffolds for bone regeneration including scaffolds characteristics and types, a focus on severe bone infections (especially osteomyelitis and its treatment), and a literature review of local antibiotic delivery by the combination of scaffolds and drug-delivery systems...
December 12, 2017: Pharmaceuticals
https://www.readbyqxmd.com/read/29231281/novel-3d-neuron-regeneration-scaffolds-based-on-synthetic-polypeptide-containing-neuron-cue
#6
Zhen-Hua Wang, Yen-Yu Chang, Jhih-Guang Wu, Chia-Yu Lin, Hsiao-Lung An, Shyh-Chyang Luo, Tang K Tang, Wei-Fang Su
Neural tissue engineering has become a potential technology to restore the functionality of damaged neural tissue with the hope to cure the patients with neural disorder and to improve their quality of life. This paper reports the design and synthesis of polypeptides containing neuron stimulate, glutamic acid, for the fabrication of biomimetic 3D scaffold in neural tissue engineering application. The polypeptides are synthesized by efficient chemical reactions. Monomer γ-benzyl glutamate-N-carboxyanhydride undergoes ring-opening polymerization to form poly(γ-benzyl-l-glutamate), then hydrolyzes into poly(γ-benzyl-l-glutamate)-r-poly(glutamic acid) random copolymer...
December 12, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29225198/perspective-in-optimization-of-stem-cell-therapies-for-heart-regeneration
#7
Paulina Gapska, Maciej Kurpisz
There is a variety of mechanisms(s) factor(s) that may influence stem cell therapies for heart regeneration. Among the best candidates for stem cell source are: mesenchymal stem cells (also those isolated from adipose tissue), cardiac cell progenitors (CPC) and descendants of iPSC cells. iPSC/s can be potentially beneficial although their pluripotent induction has been still in question due to: low propagation efficacy, danger of genomic integration/instability, biological risk of current vector system teratoma formation etc...
December 7, 2017: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/29222674/effect-of-rehabilitation-exercise-durations-on-the-dynamic-bone-repair-process-by-coupling-polymer-scaffold-degradation-and-bone-formation
#8
Quan Shi, Qiang Chen, Nicola Pugno, Zhi-Yong Li
Implantation of biodegradable scaffold is considered as a promising method to treat bone disorders, but knowledge of the dynamic bone repair process is extremely limited. In this study, based on the representative volume cell of a periodic scaffold, the influence of rehabilitation exercise duration per day on the bone repair was investigated by a computational framework. The framework coupled scaffold degradation and bone remodeling. The scaffold degradation was described by a function of stochastic hydrolysis independent of mechanical stimulation, and the bone formation was remodeled by a function of the mechanical stimulation, i...
December 8, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/29215076/a-novel-electroactive-agarose-aniline-pentamer-platform-as-a-potential-candidate-for-neural-tissue-engineering
#9
Payam Zarrintaj, Behnaz Bakhshandeh, Iraj Rezaeian, Behnam Heshmatian, Mohammad Reza Ganjali
Neuronal disorder is an important health challenge due to inadequate natural regeneration, which has been responded by tissue engineering, particularly with conductive materials. A bifunctional electroactive scaffold having agarose biodegradable and aniline pentamer (AP) conductive parts was designed that exhibits appropriate cell attachment/compatibility, as detected by PC12 cell seeding. The developed carboxyl-capped aniline-pentamer improved agarose cell adhesion potential, also the conductivity of scaffold was in the order 10-5 S/cm reported for cell membrane...
December 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29204380/electrospun-polycaprolactone-lignin-based-nanocomposite-as-a-novel-tissue-scaffold-for-biomedical-applications
#10
Mohammad Ali Salami, Faranak Kaveian, Mohammad Rafienia, Saeed Saber-Samandari, Amirsalar Khandan, Mitra Naeimi
Background: Biopolymer scaffolds have received great interest in academic and industrial environment because of their supreme characteristics like biological, mechanical, chemical, and cost saving in the biomedical science. There are various attempts for incorporation of biopolymers with cheap natural micro- or nanoparticles like lignin (Lig), alginate, and gums to prepare new materials with enhanced properties. Methods: In this work, the electrospinning (ELS) technique as a promising cost-effective method for producing polymeric scaffold fibers was used, which mimics extracellular matrix structure for soft tissue engineering applications...
October 2017: Journal of Medical Signals and Sensors
https://www.readbyqxmd.com/read/29193687/in-vitro-and-in-vivo-biological-characterization-of-poly-lactic-acid-fiber-scaffolds-synthesized-by-air-jet-spinning
#11
Marco Vladimir Granados-Hernández, Janeth Serrano-Bello, Juan José Montesinos, Carlos Alvarez-Gayosso, Luis Alberto Medina-Velázquez, Octavio Alvarez-Fregoso, Marco Antonio Alvarez-Perez
Poly(lactic acid) (PLA) is one of the most promising renewable and biodegradable polymers for mimic extracellular matrix for tissue engineering applications. In this work, PLA spun membrane scaffold were successfully prepared by air jet spinning technology. Morphology, mechanical properties, in vitro biocompatibility, and in vitro and in vivo degradation of PLA fibrous scaffold were characterized by X-ray diffraction, Fourier Transform Infrared, and scanning electron microscope (SEM). Morphological results assessed by SEM analyses indicated that PLA scaffolds possessed an average fiber diameter of approximately 0...
November 30, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29190463/genipin-treated-chitosan-nanofibers-as-a-novel-scaffold-for-nerve-guidance-channel-design
#12
Yu-Ting Lau, Lam-Fung Kwok, Kin-Wai Tam, Ying-Shing Chan, Daisy Kwok-Yan Shum, Graham Ka-Hon Shea
Schwann cell-seeded nerve guidance channels are designed to assist post-traumatic nerve regeneration in the PNS. Chitosan is a natural polymer well suited for tissue engineering as it is biocompatible, non-immunogenic, and biodegradable. Electrospun chitosan nanofibers utilized in nerve guidance channels have the capacity for guiding axonal growth within the channel lumen yet are limited in their capacity to maintain structural integrity within physiological environments. To address this, we attempted genipin crosslinking of chitosan nanofibers...
November 23, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29183194/multidimensional-mass-spectrometry-characterization-of-isomeric-biodegradable-polyesters
#13
Sahar Sallam, Yuanyuan Luo, Matthew L Becker, Chrys Wesdemiotis
The biodegradable polyester copolymer poly(propylene fumarate) (PPF) is increasingly utilized in bone tissue engineering studies due to its suitability as inert cross-linkable scaffold material. The well-defined poly(propylene fumarate) oligomers needed for this purpose are synthesized by post-polymerization isomerization of poly(propylene maleate), which is prepared by ring opening polymerization of maleic anhydride and propylene oxide. In this study, multidimensional mass spectrometry methodologies, interfacing matrix-assisted laser desorption ionization and electrospray ionization with mass analysis, tandem mass spectrometry fragmentation and/or ion mobility mass spectrometry, have been employed to characterize the composition, end groups, chain connectivity and isomeric purity of the isomeric copolyesters poly(propylene maleate)and poly(propylene fumarate)...
December 2017: European Journal of Mass Spectrometry
https://www.readbyqxmd.com/read/29178402/micro-nanostructures-of-cellulose-collagen-for-critical-sized-bone-defect-healing
#14
Aja Aravamudhan, Daisy M Ramos, Jonathan Nip, Ivo Kalajzic, Sangamesh G Kumbar
Bone tissue engineering strategies utilize biodegradable polymeric matrices alone or in combination with cells and factors to provide mechanical support to bone, while promoting cell proliferation, differentiation, and tissue ingrowth. The performance of mechanically competent, micro-nanostructured polymeric matrices, in combination with bone marrow stromal cells (BMSCs), is evaluated in a critical sized bone defect. Cellulose acetate (CA) is used to fabricate a porous microstructured matrix. Type I collagen is then allowed to self-assemble on these microstructures to create a natural polymer-based, micro-nanostructured matrix (CAc)...
November 27, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29172421/biomimetic-domain-active-electrospun-scaffolds-facilitating-bone-regeneration-synergistically-with-antibacterial-efficacy-for-bone-defects
#15
YunZhu Qian, Xuefeng Zhou, Hong Sun, Jianxin Yang, Yi Chen, Chao Li, Hongjin Wang, Tong Xing, FeiMin Zhang, Ning Gu
To improve bone regeneration in oral microenvironment, we generated a novel biodegradable, antibacterial and osteoconductive electrospun PLGA/PCL membrane as an ideal osteogenic scaffold. The novel 3-layer membranes were structured with serial layers of electrospun chlorhexidine-doped-PLGA/PCL (PPC), PLGA/PCL (PP), and -tricalcium phosphate-doped-PLGA/PCL (PP. To characterize osteoconductive properties of these membranes, MC3T3-E1 (MC) cultures were seeded onto the membranes for 14 days for evaluation of cell proliferation, morphology and gene/protein expression...
November 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29171974/co-existence-effect-of-tricalcium-phosphate-and-bioactive-glass-on-biological-and-biodegradation-characteristic-of-poly-l-lactic-acid-plla-in-trinary-composite%C3%A2-scaffold-form
#16
Abbas Ghasemi, Babak Hashemi
The purpose of this study is to analyze the co-existence effect of 30 wt.% TCP-BG phases on degradation and precipitation behaviors of PLLA based composite scaffold in biological media. First, phase separation method was used to synthesize of the pure PLLA and the trinary composite scaffolds, and second they were immersed in SBF solution for 45 days. Subsequently, the degradation and precipitation characteristic were investigated by analyzing of pH value and weight changes of the immersed samples, the ability of biological products formation and the change of relative molecular weight of PLLA matrix as function of the degradation time...
2017: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/29170715/biocompatible-degradable-thermoplastic-polyurethane-based-on-polycaprolactone-block-polytetrahydrofuran-block-polycaprolactone-copolymers-for-soft-tissue-engineering
#17
Hao-Yang Mi, Xin Jing, Brett N Napiwocki, Breanna S Hagerty, Guojun Chen, Lih-Sheng Turng
Biodegradable synthetic polymers have been widely used as tissue engineering scaffold materials. Even though they have shown excellent biocompatibility, they have failed to resemble the low stiffness and high elasticity of soft tissues because of the presence of massive rigid ester bonds. Herein, we synthesized a new thermoplastic polyurethane elastomer (CTC-PU(BET)) using poly ester ether triblock copolymer (polycaprolactone-block-polytetrahydrofuran-block-polycaprolactone triblock copolymer, PCTC) as the soft segment, aliphatic diisocyanate (hexamethylene diisocyanate, HDI) as the hard segment, and degradable diol (bis(2-hydroxyethyl) terephthalate, BET) as the chain extender...
June 14, 2017: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://www.readbyqxmd.com/read/29160629/chitosan-and-its-composites-properties-for-use-in-bone-substitution
#18
REVIEW
Marek Stępniewski, Jacek Martynkiewicz, Jerzy Gosk
For many years, research has been carried out on finding an ideal bone substitute. Chitosan (CTS) is a naturally occurring polysaccharide, obtained mainly from, inter alia, the shells of crustaceans. It is characterized by its high level of biocompatibility, biodegradability and antimicrobial properties as well as its support in the healing of wounds. Chitosan, due to its ability to form porous structures, can be used in the production of scaffolds used in the treatment of bone defects. There are numerous studies on the use of CTS in combination with other substances which aim to improve its biological and mechanical properties...
January 2017: Polimery W Medycynie
https://www.readbyqxmd.com/read/29160048/from-biodegradable-polymers-to-bioresorbable-vascular-scaffolds-available-evidence-in-the-current-era-of-new-generation-des
#19
Fabio Magliulo, Raffaele Piccolo, Anna Franzone, Giovanni Esposito, Gian B Danzi
New-generation drug-eluting stents (DES) encompass a large variety of coronary devices, featuring thin struts, biocompatible durable or biodegradable polymer coatings, and limus-eluting drugs. Due to improved early and long-term outcomes among patients undergoing percutaneous coronary intervention, new-generation metallic DES are recommended in almost all patient and lesion subsets. Available evidence from randomized trials indicate a similar safety and efficacy profile between biodegradable and durable polymers new-generation DES...
November 20, 2017: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/29154874/preparation-and-characterization-of-three-dimensional-scaffolds-based-on-hydroxypropyl-chitosan-graft-graphene-oxide
#20
P R Sivashankari, A Moorthi, K Mohamed Abudhahir, M Prabaharan
Hydroxypropyl chitosan (HPCH), a water soluble derivative of chitosan, is widely considered for tissue engineering and wound healing applications due to its biocompatibility and biodegradability. Graphene oxide (GO) is a carbon-based nanomaterial which is capable of imparting desired properties to the scaffolds. Hence, the integration of GO into HPCH could allow for the production of HPCH-based scaffolds with improved swelling character, mechanical strength, and stability aimed at being used in tissue engineering...
November 14, 2017: International Journal of Biological Macromolecules
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