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Biodegradable scaffold

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https://www.readbyqxmd.com/read/28433936/sustained-viral-gene-delivery-from-a-micro-fibrous-elastomeric-cardiac-patch-to-the-ischemic-rat-heart
#1
Xinzhu Gu, Yasumoto Matsumura, Ying Tang, Souvik Roy, Richard Hoff, Bing Wang, William R Wagner
Biodegradable and elastomeric patches have been applied to the surface of infarcted hearts as temporary mechanical supports to effectively alter adverse left ventricular remodeling processes. In this report, recombinant adeno-associated virus (AAV), known for its persistent transgene expression and low pathogenicity, was incorporated into elastomeric polyester urethane urea (PEUU) and polyester ether urethane urea (PEEUU) and processed by electrospinning into two formats (solid fibers and core-sheath fibers) designed to influence the controlled release behavior...
April 14, 2017: Biomaterials
https://www.readbyqxmd.com/read/28428056/recent-development-of-synthetic-nonviral-systems-for-sustained-gene-delivery
#2
REVIEW
Yonggang Xiang, Nwe Nwe Linn Oo, Jin Ping Lee, Zibiao Li, Xian Jun Loh
Sustained gene delivery is of particular importance today because it circumvents the need for repeated therapeutic administration and provides spatial and temporal control of the release profile. Better understanding of the genetic basis of diseases and advances in gene therapy have propelled significant research on biocompatible gene carriers for therapeutic purposes. Varied biodegradable polymer-based architectures have been used to create new compositions with unique properties suitable for sustained gene delivery...
April 17, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/28419941/pamam-generation-4-incorporated-gelatin-3d-matrix-as-an-improved-dermal-substitute-for-skin-tissue-engineering
#3
Somnath Maji, Tarun Agarwal, Tapas Kumar Maiti
The study explored the prospects of PAMAM (generation 4) applicability in gelatin based scaffolds for skin tissue engineering. The effect of PAMAM on physico-chemical and biological characteristics of gelatin scaffolds was evaluated. Gelatin scaffolds (with/without PAMAM) were prepared by lyophilization, chemically crosslinked by glutaraldehyde and characterized for their morphology (pore size), chemical features (bond nature), water adsorption, biodegradation and biological compatibility. The study demonstrated that addition of PAMAM did not significantly alter the pore size distribution or porosity of the scaffolds...
April 5, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28416308/implantation-of-endothelial-cells-with-mesenchymal-stem-cells-accelerates-dental-pulp-tissue-regeneration-healing-in-pulpotomized-rat-molars
#4
Yukiko Sueyama, Tomoatsu Kaneko, Takafumi Ito, Reika Kaneko, Takashi Okiji
INTRODUCTION: This study aimed to examine whether the implantation of mesenchymal stem cells (MSCs) with endothelial cells (ECs) accelerates pulp tissue regeneration/healing and induces dentin bridge formation in a rat model of molar coronal pulp regeneration. METHODS: The maxillary first molars of Wistar rats were subjected to pulpotomy. Then, pulp chambers were implanted with biodegradable hydrogel-made scaffolds carrying MSCs together or without dermal microvascular ECs, and the cavities were sealed with mineral trioxide aggregate...
April 14, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28415532/preparation-of-micro-porous-bioceramic-containing-silicon-substituted-hydroxyapatite-and-beta-tricalcium-phosphate
#5
Lih-Jyh Fuh, Ya-Jing Huang, Wen-Cheng Chen, Dan-Jae Lin
Dimensional instability caused by sintering shrinkage is an inevitable drawback for conventional processing of hydroxyapatite (HA). A new preparation method for biphasic calcium phosphates was developed to increase micro pores and biodegradation without significant dimensional change. Powder pressed HA discs, under 100MPa, were immersed in a colloidal mixture of tetraethoxysilane (TEOS) and ammonium hydroxide for 10min, followed by drying, and then were sintered at 900°C, 1050°C, and 1200°C, respectively...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28415517/fabrication-of-novel-biodegradable-porous-bone-scaffolds-based-on-amphiphilic-hydroxyapatite-nanorods
#6
Xiaoyan Zheng, Junfeng Hui, Hui Li, Chenhui Zhu, Xiufu Hua, Haixia Ma, Daidi Fan
This paper describes a new synthetic strategy and biological application for novel amphiphilic hydroxyapatite (HAp) nanorods. The prepared HAp nanorods were able to be dispersed in water, ethyl alcohol and cyclohexane. The co-anchoring of the multidentate ligands of PEG 20000 and hydrophobic oleic acid (OA) on the rods' surfaces endowed them with excellent amphibious properties. Utilizing amphiphilic HAp nanorods with excellent biocompatibility as the inorganic phase, human-like collagen (HLC) as the organic phase and natural genipin as the cross-linker, optimal HLC/HAp porous scaffolds (HLC: HAp=1:4, w/w) were fabricated...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28415483/an-investigation-of-electrospun-henna-leaves-extract-loaded-chitosan-based-nanofibrous-mats-for-skin-tissue-engineering
#7
Iman Yousefi, Mehdi Pakravan, Hoda Rahimi, Abbas Bahador, Zahra Farshadzadeh, Ismael Haririan
Wound healing characteristics of some plant extracts have been well known for many years, and they have been utilized for such applications in traditional way. Recently electrospun nanofibrous mats showed promising properties for tissue engineering and especially for skin repair. It is expected that incorporation of plant extracts into such structures could provide higher performance and synergistic effect for biomedical and wound healing applications. The final purpose of this study is to fabricate chitosan based nanofiber mats loaded with a traditional plant extract of Lawsonia inermis (Henna) leaves to enhance the antibacterial efficacy and wound healing of the precursor nanofibers...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28408454/bioresorbable-scaffold-the-emerging-reality-and-future-directions
#8
REVIEW
Yohei Sotomi, Yoshinobu Onuma, Carlos Collet, Erhan Tenekecioglu, Renu Virmani, Neal S Kleiman, Patrick W Serruys
In the era of drug-eluting stents, large-scale randomized trials and all-comer registries have shown excellent clinical results. However, even the latest-generation drug-eluting stent has not managed to address all the limitations of permanent metallic coronary stents, such as the risks of target lesion revascularization, neoatherosclerosis, preclusion of late lumen enlargement, and the lack of reactive vasomotion. Furthermore, the risk of very late stent, although substantially reduced with newer-generation drug-eluting stent, still remains...
April 14, 2017: Circulation Research
https://www.readbyqxmd.com/read/28402967/surface-curvature-in-triply-periodic-minimal-surface-architectures-as-a-distinct-design-parameter-in-preparing-advanced-tissue-engineering-scaffolds
#9
Sébastien B G Blanquer, Maike Werner, Markus Hannula, Shahriar Sharifi, Guillaume P R Lajoinie, David Eglin, Jari Hyttinen, André A Poot, Dirk W Grijpma
Reproduction of the anatomical structures and functions of tissues using cells and designed 3D scaffolds is an ongoing challenge. For this, scaffolds with appropriate biomorphic surfaces promoting cell attachment, proliferation and differentiation are needed. In this study, eight triply-periodic minimal surface (TPMS)-based scaffolds were designed using specific trigonometric equations, providing the same porosity and the same number of unit cells, while presenting different surface curvatures. The scaffolds were fabricated by stereolithography using a photocurable resin based on the biocompatible, biodegradable and rubber-like material, poly(trimethylene carbonate) (PTMC)...
April 12, 2017: Biofabrication
https://www.readbyqxmd.com/read/28385228/comparative-study-on-the-healing-potential-of-chitosan-polymethylmethacrylate-and-demineralized-bone-matrix-in-radial-bone-defects-of-rat
#10
Soodeh Alidadi, Ahmad Oryan, Amin Bigham-Sadegh, Ali Moshiri
This study aimed to compare the effectiveness of xenogeneic demineralized bone matrix (DBM), chitosan (CS), and polymethylmethacrylate (PMMA) on the regeneration of the critical-sized radial bone defects in rats after eight weeks. Fifty bilateral radial bone defects were randomly divided into five groups including untreated defects and those treated with autograft, CS scaffold, PMMA, and DBM. The defects were evaluated by diagnostic imaging, histopathology, histomorphometry, scanning electron microscopy, and biomechanical testing...
June 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28382732/engineering-vascularized-flaps-using-adipose-derived-microvascular-ec-and-msc
#11
Alina Freiman, Yulia Shandalov, Dekel Rosenfeld, Erez Shor, Dror Ben-David, Shai Meretzki, Shulamit Levenberg, Dana Egozi
Human adipose-derived microvascular endothelial cells (HAMEC) and mesenchymal stem cells (MSC) have been shown to bear angiogenic and vasculogenic capabilities. We hypothesize that co-culturing HAMEC:MSC on a porous biodegradable scaffold in vitro, later implanted as a graft around femoral blood vessels in a rat, will result in its vascularization by host vessels, creating a functional vascular flap that can effectively treat a range of large full-thickness soft tissue defects. HAMEC were co-cultured with MSC on polymeric 3D porous constructs...
April 6, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28380080/biodegradable-poly-lactic-acid-co-glycolic-acid-scaffolds-as-carriers-for-genetically-modified-fibroblasts
#12
Tatjana Perisic, Ziyang Zhang, Peter Foehr, Ursula Hopfner, Kathrin Klutz, Rainer H Burgkart, Alexei Slobodianski, Moritz Goeldner, Hans-Günther Machens, Arndt F Schilling
Recent advances in gene delivery into cells allow improved therapeutic effects in gene therapy trials. To increase the bioavailability of applied cells, it is of great interest that transfected cells remain at the application site and systemic spread is minimized. In this study, we tested clinically used biodegradable poly(lactic acid-co-glycolic acid) (PLGA) scaffolds (Vicryl & Ethisorb) as transient carriers for genetically modified cells. To this aim, we used human fibroblasts and examined attachment and proliferation of untransfected cells on the scaffolds in vitro, as well as the mechanical properties of the scaffolds at four time points (1, 3, 6 and 9 days) of cultivation...
2017: PloS One
https://www.readbyqxmd.com/read/28375818/chondrocyte-attachment-proliferation-and-differentiation-on-three-dimensional-polycaprolactone-fumarate-scaffolds
#13
Eric R Wagner, Joshua Parry, Mahrokh Dadsetan, Dalibel Bravo, Scott M Riester, Andre J van Wijnen, Michael J Yaszemski, Sanjeev Kakar
Current treatment options for cartilage injuries are limited. The goals of this study are to create a biodegradable polymer scaffold with the capabilities of sustaining chondrocyte growth and proliferation, enable cell-to-cell communication and tissue regeneration through large pores, and assess the biological augmentation of the scaffold capabilities using platelet lysate (PL). We synthesized biodegradable polycaprolactone fumarate (PCLF) scaffolds to allow cell-cell communication through large interconnected pores...
March 31, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28368852/biomedical-applications-of-nanodiamond-review
#14
Kostiantyn Turcheniuk, Vadym Mochalin
The interest to applications of nanodiamond in biology and medicine is on the rise over the recent years. This is due to the unique combination of properties that nanodiamond provides. Small size (~ 5 nm), low cost, scalable production, negligible toxicity, chemical inertness of diamond core and rich chemistry of nanodiamond surface, as well as bright and robust fluorescence resistant to photobleaching are the distinct parameters that render nanodiamond superior to any other nanomaterial when it comes to biomedical applications...
April 3, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28363647/chitosan-gelatin-platelet-gel-enriched-by-a-combination-of-hydroxyapatite-and-beta-tricalcium-phosphate-in-healing-of-a-radial-bone-defect-model-in-rat
#15
Ahmad Oryan, Soodeh Alidadi, Amin Bigham-Sadegh, Abdolhamid Meimandi-Parizi
This study compared the regeneration potentials of the hydroxyapatite (HA) and beta-tricalcium phosphate (β-TCP) alone or in combination with a HA:TCP ratio of 30:70 in the critical-sized radial bone defects of rats. Bilateral 60 radial bone defects created were randomly divided into six equal groups (n=10 defects/group) including autograft, untreated or defect, chitosan-gelatin-platelet gel (CGP), CGP-HA, CGP-TCP and CGP-HA/TCP. The defects were evaluated by radiography, morphology, histopathology, histomorphometry, CT scan, scanning electron microscopy and biomechanical testing after eight weeks...
March 28, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28351999/osteoblast-and-osteoclast-responses-to-a-b-type-carbonate-substituted-hydroxyapatite-ceramics-for-bone-regeneration
#16
Marie-Michèle Germaini, Rainer Detsch, Alina Grünewald, Amandine Magnaudeix, Fabrice Lalloué, Aldo Boccaccini, Eric Champion
The influence of carbonate substitution (4.4 wt%, mixed A/B type) in hydroxyapatite ceramics for bone remodeling scaffolds was investigated by analyzing separately the response of pre-osteoblasts and osteoclast-like cells. Carbonated hydroxyapatite (Ca<sub>9.5</sub>(PO<sub>4</sub>)<sub>5.5</sub>(CO<sub>3</sub>)<sub>0.5</sub>(OH)(CO<sub>3</sub>)<sub>0.25</sub> - CHA) mimicking the chemical composition of natural bone mineral and pure hydroxyapatite (Ca<sub>10</sub>(PO<sub>4</sub>)<sub>6</sub>(OH)<sub>2</sub> - CHA) porous ceramics were processed to obtain similar microstructure and surface physico-chemical properties (grain size, porosity ratio and pore size, surface roughness and zeta potential)...
March 29, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28351682/two-photon-polymerization-for-production-of-human-ipsc-derived-retinal-cell-grafts
#17
Kristan S Worthington, Luke A Wiley, Emily E Kaalberg, Malia M Collins, Robert F Mullins, Edwin M Stone, Budd A Tucker
Recent advances in induced pluripotent stem cell (iPSC) technology have paved the way for the production of patient-specific neurons that are ideal for autologous cell replacement for treatment of neurodegenerative diseases. In the case of retinal degeneration and associated photoreceptor cell therapy, polymer scaffolds are critical for cellular survival and integration; however, prior attempts to materialize this concept have been unsuccessful in part due to the materials' inability to guide cell alignment...
March 25, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28350456/starch-derived-nanographene-oxide-paves-the-way-for-electrospinnable-and-bioactive-starch-scaffolds-for-bone-tissue-engineering
#18
Duo Wu, Archana Samanta, Rajiv K Srivastava, Minna Hakkarainen
A straightforward process that enabled electrospinning of bioactive starch-based nanofiber scaffolds was developed by utilizing starch derived nano graphene oxide (nGO) as a property enhancer and formic acid as a solvent and esterification reagent. The reaction mechanism and process were followed by detailed spectroscopic investigation. Furthermore, the incorporation of nGO as a "green bioactive additive" endorsed starch nanofibrous scaffolds several advantageous functionalities including improved electrospinnability and thermal stability, good cytocompatibility, osteo-bioactivity, and retained biodegradability...
March 31, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28346381/multifaceted-applications-of-chitosan-in-cancer-drug-delivery-and-therapy
#19
REVIEW
Anish Babu, Rajagopal Ramesh
Chitosan is a versatile polysaccharide of biological origin. Due to the biocompatible and biodegradable nature of chitosan, it is intensively utilized in biomedical applications in scaffold engineering as an absorption enhancer, and for bioactive and controlled drug release. In cancer therapy, chitosan has multifaceted applications, such as assisting in gene delivery and chemotherapeutic delivery, and as an immunoadjuvant for vaccines. The present review highlights the recent applications of chitosan and chitosan derivatives in cancer therapy...
March 27, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28345891/tailored-chemical-properties-of-4-arm-star-shaped-poly-d-l-lactide-as-cell-adhesive-three-dimensional-scaffolds
#20
Chelladurai Karthikeyan Balavigneswaran, Sanjeev Kumar Mahto, Bano Subia, Arumugam Prabhakar, Kheyanath Mitra, Vivek Rao, Munia Ganguli, Biswajit Ray, Pralay Maiti, Nira Misra
Biodegradable poly(lactic acid) (PLA) is widely used to fabricate 3D scaffolds for tissue regeneration. However, PLA lacks cell adhering functional moieties, which limit its successful application in tissue engineering. Herein, we have tailored the cell adhesive properties of star shaped poly(d,l-lactide) (ss-PDLLA) by grafting gelatin to their 4 arms. Grafting of gelatin on PDLLA backbone was confirmed by (1)H NMR and FTIR. The synthesized star shaped poly(d,l-lactide)-b-gelatin (ss-pLG) exhibited enhanced wettability and protein adsorption...
April 10, 2017: Bioconjugate Chemistry
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