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Biodegradable scaffold

Natashya Falcone, Heinz-Bernhard Kraatz
Supramolecular gels are a fascinating class of soft materials that have attracted significant attention in recent years. They are composed of small molecule gelators that assemble into supramolecular network structures. The resulting space is filled with solvent. Some gel materials are able to respond to various stimuli making them attractive drug delivery vehicles and as matrices for tissue regeneration. Peptide based gel materials are particularly attractive as they possess numerous advantages including biocompatibility and biodegradability...
April 18, 2018: Chemistry: a European Journal
Renze Shen, Weihong Xu, Yanxiang Xue, Luyuan Chen, Haicheng Ye, Enyi Zhong, Zhanchao Ye, Jie Gao, Yurong Yan
OBJECTIVE: In this study, nanofibrous scaffolds base on pure polylactic acid (PLA) and chitosan/PLA blends were fabricated by emulsion eletrospinning. By modulating their mechanical and biological properties, cell-compatible and biodegradable scaffolds were developed for periodontal bone regeneration. METHODS: Pure PLA and different weight ratios of chitosan nano-particle/PLA nano-fibers were fabricated by emulsion eletrospinning. Scanning electron microscope (SEM) was performed to observe the morphology of nano-fibers...
April 16, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Zahra Shariatinia, Azin Mazloom Jalali
Chitosan (CS), the second most plentiful natural polysaccharide next to cellulose, has valuable characteristics including biocompatibility, nontoxicity and biodegradability. CS is broken down in the human body to innocuous products (amino sugars). Hydrogels are polymeric materials with three dimensional networks retaining a huge quantity of water within their structures which are of great interest in biomedical/environmental applications. Usually, injectable hydrogels have functional groups which are sensitive to pH, temperature or irradiation stimuli...
April 13, 2018: International Journal of Biological Macromolecules
Franziska Koch, Michael Müller, Finja König, Nina Meyer, Jasmin Gattlen, Uwe Pieles, Kirsten Peters, Bernd Kreikemeyer, Stephanie Mathes, Sina Saxer
Self-assembling peptide hydrogels can be modified regarding their biodegradability, their chemical and mechanical properties and their nanofibrillar structure. Thus, self-assembling peptide hydrogels might be suitable scaffolds for regenerative therapies and tissue engineering. Owing to the use of various peptide concentrations and buffer compositions, the self-assembling peptide hydrogels might be influenced regarding their mechanical characteristics. Therefore, the mechanical properties and stability of a set of self-assembling peptide hydrogels, consisting of 11 amino acids, made from four beta sheet self-assembling peptides in various peptide concentrations and buffer compositions were studied...
March 2018: Royal Society Open Science
Remya K R, Sunitha Chandran, Susan Mani, Annie John, P Ramesh
In the present study, we attempt to modify Polycaprolactone (PCL) by blending it with a water soluble polymer Polyethyleneoxide (PEO) having two different molecular weights (Mv ~1,00,000 and 6,00,000) using electrospinning technique. The effect of PEO molecular weight and blend ratio on fiber morphology, porosity, surface wettability, static and dynamic mechanical properties of PCL was investigated. In vitro degradation studies in phosphate buffer saline (PBS) at 37°C demonstrated formation of pores on fiber surface especially in blend scaffolds with 50:50 ratios...
April 16, 2018: Journal of Biomaterials Science. Polymer Edition
Dominik Steiner, Lara Lingens, Laura Fischer, Katrin Köhn, Rainer Detsch, Aldo Roberto Boccaccini, Tobias Fey, Peter Greil, Christian Weis, Justus Beier, Raymund E Horch, Andreas Arkudas
Vascularization of bioartificial tissues can be significantly enhanced by the generation of an arterio-venous loop (AV loop). Besides the surgical vascularization, the choice of the scaffold and the applied cells are indispensable cofactors. The combination of alginate dialdehyde and gelatin (ADA-GEL) and mesenchymal stem cells (MSCs) is a promising approach with regards to biocompatibility, biodegradation as well as de novo tissue formation. In this study we targeted the investigation of the vascularization of ADA-GEL with and in absence of encapsulated MSCs in the AV loop model...
March 20, 2018: Tissue Engineering. Part A
Lei Chen, Cuijun Deng, Jiayi Li, Qingqiang Yao, Jiang Chang, Liming Wang, Chengtie Wu
It is difficult to achieve self-healing outcoming for the osteochondral defects caused by degenerative diseases. The simultaneous regeneration of both cartilage and subchondral bone tissues is an effective therapeutic strategy for osteochondral defects. However, it is challenging to design a single type of bioscaffold with suitable ionic components and beneficial osteo/chondral-stimulation ability for regeneration of osteochondral defects. In this study, we successfully synthesized a pure-phase lithium calcium silicate (Li2 Ca4 Si4 O13 , L2 C4 S4 ) bioceramic by a sol-gel method, and further prepared L2 C4 S4 scaffolds by using a 3D-printing method...
April 4, 2018: Biomaterials
Veroniki Bakola, Varvara Karagkiozaki, Aikatherini-Rafailia Tsiapla, Foteini Pappa, Ioannis Moutsios, Eleni Pavlidou, Stergious Logothetidis
Cardiovascular Stents are commonly used for the treatment of Cardiovascular Diseases (CVDs) that in developed societies, are the most frequent causes of mortality and morbidity. Recent years, thorough research and development of Drug Eluting Stents (DES) has been done, with emphasis on coronary stenting to avoid the most common complication, the in-stent thrombosis. Dipyridamole (DPM) is a medication that inhibits blood clot formation. Drug Delivery Nanoplatforms consisting of biodegradable polymers can be fabricated via Electrospinning Deposition, known for its cost-effective and versatile advantages, that produces fibrous scaffolds able of sustainable and controllable drug release...
April 9, 2018: Nanotechnology
Viviana P Ribeiro, Alain da Silva Morais, F Raquel Maia, Raphael F Canadas, João B Costa, Ana L Oliveira, Joaquim M Oliveira, Rui L Reis
Several processing technologies and engineering strategies have been combined to create scaffolds with superior performance for efficient tissue regeneration. Cartilage tissue is a good example of that, presenting limited self-healing capacity together with a high elasticity and load-bearing properties. In this work, novel porous silk fibroin (SF) scaffolds derived from horseradish peroxidase (HRP)-mediated crosslinking of highly concentrated aqueous SF solution (16 wt.%) in combination with salt-leaching and freeze-drying methodologies were developed for articular cartilage tissue engineering (TE) applications...
April 4, 2018: Acta Biomaterialia
Kamyar Esmaeili Pourfarhangi, Shohreh Mashayekhan, Sasan Ghanbari Asl, Zahra Hajebrahimi
High rates of mortality and morbidity stemming from cardiovascular diseases unveil extreme limitations in current therapies despite enormous advances in medical and pharmaceutical sciences. Following myocardial infarction (MI), parts of myocardium undergo irreversible remodeling and is substituted by a scar tissue which eventually leads to heart failure (HF). To address this issue, cardiac patches have been utilized to initiate myocardial regeneration. In this study, a porous cardiac patch is fabricated using a mixture of decellularized myocardium extracellular matrix (ECM) and chitosan (CS)...
April 3, 2018: Biologicals: Journal of the International Association of Biological Standardization
Payam Zarrintaj, Behnaz Bakhshandeh, Mohammad Reza Saeb, Farshid Sefat, Iraj Rezaeian, Mohammad Reza Ganjali, Seeram Ramakrishna, Masoud Mozafari
The science and engineering of biomaterials have improved the human life expectancy. Tissue engineering is one of the nascent strategies with an aim to fulfill this target. Tissue engineering scaffolds are one of the most significant aspects of the recent tissue repair strategies; hence, it is imperative to design biomimetic substrates with suitable features. Conductive substrates can ameliorate the cellular activity through enhancement of cellular signaling. Biocompatible polymers with conductivity can mimic the cells' niche in an appropriate manner...
April 3, 2018: Acta Biomaterialia
Zi-Ang Yao, Feng-Jia Chen, Hong-Li Cui, Tong Lin, Na Guo, Hai-Ge Wu
Spinal cord injury results in the loss of motor and sensory pathways and spontaneous regeneration of adult mammalian spinal cord neurons is limited. Chitosan and sodium alginate have good biocompatibility, biodegradability, and are suitable to assist the recovery of damaged tissues, such as skin, bone and nerve. Chitosan scaffolds, sodium alginate scaffolds and chitosan-sodium alginate scaffolds were separately transplanted into rats with spinal cord hemisection. Basso-Beattie-Bresnahan locomotor rating scale scores and electrophysiological results showed that chitosan scaffolds promoted recovery of locomotor capacity and nerve transduction of the experimental rats...
March 2018: Neural Regeneration Research
Lingli Li, Conglie Lu, Lei Wang, Mei Chen, Jacinta F White, Xiaojuan Hao, Keith M McLean, Hao Chen, Timothy C Hughes
In this study, an injectable, photo-curable gelatin system, consisting of acrylated gelatin and thiolated gelatin, with tunable mechanical, biodegradation and biological properties was used as a potential cell supportive scaffold for the repair of focal corneal wounds. The mechanical property of hydrogels can be readily modified (post-cure shear modulus of between 0.3 and 22 kPa) by varying the ratio of acrylate to thiol groups, photo intensity and solids content, and the biodegradation times also varied with change of solids content...
April 5, 2018: ACS Applied Materials & Interfaces
Toktam Ghassemi, Azadeh Shahroodi, Mohammad H Ebrahimzadeh, Alireza Mousavian, Jebraeel Movaffagh, Ali Moradi
Bone disorders are of significant worry due to their increased prevalence in the median age. Scaffold-based bone tissue engineering holds great promise for the future of osseous defects therapies. Porous composite materials and functional coatings for metallic implants have been introduced in next generation of orthopedic medicine for tissue engineering. While osteoconductive materials such as hydroxyapatite and tricalcium phosphate ceramics as well as some biodegradable polymers are suggested, much interest has recently focused on the use of osteoinductive materials like demineralized bone matrix or bone derivatives...
March 2018: Archives of Bone and Joint Surgery
Ahmad Oryan, Soodeh Alidadi
AIMS: Despite many attempts, an appropriate therapeutic method has not yet been found to enhance bone formation, mechanical strength and structural and functional performances of large bone defects. In the present study, the bone regenerative potential of calcium silicate (CS) biomaterials combined with chitosan (CH) as calcium silicate/chitosan (CSC) scaffold was investigated in a critical radial bone defect in a rat model. MAIN METHODS: The bioimplants were bilaterally implanted in the defects of 20 adult Sprague-Dawley rats...
March 26, 2018: Life Sciences
Elayaraja Kolanthai, Abinaya Sindu P, Deepak Kumar Khajuria, Sarath Chandra Veerla, Dhandapani Kuppuswamy, Luiz Henrique Catalani, D Roy Mahapatra
Developing a biodegradable scaffold remains a major challenge in bone tissue engineering. This study was aimed at developing novel alginate-chitosan-collagen (SA-CS-Col) based composite scaffolds consisting of graphene oxide (GO) to enrich porous structures, elicited by freeze-drying technique. To characterize porosity, water absorption and compressive modulus, GO scaffolds (SA-CS-Col-GO) were prepared with and without Ca2+ -mediated crosslinking (chemical crosslinking) and analyzed using Raman, FTIR, XRD, and SEM techniques...
March 28, 2018: ACS Applied Materials & Interfaces
Naglaa Salem El-Sayed, Mohamed El-Sakhawy, Peter Hesemann, Nicolas Brun, Samir Kamel
The development of new biocompatible, biodegradable functionalized biopolymers that can serve as scaffold for tissue regeneration or work as carriers for different bioactive molecules such as drugs, proteins, and enzymes remains a continuous challenge that need to be extensively explored. For this purpose, three water-soluble cellulose derivatives; namely 4(celluloseamino) butyric acid (CABA) 2(celluloseamino) succinic acid (CASA), and 3(celluloseamino) propane sulfonic acids (CAPSA) were synthesized from microcrystalline cellulose (MCC) via esterification with tosyl chloride that was followed by nucleophilic substitution by the proper aminoalkyl acid derivative...
March 24, 2018: International Journal of Biological Macromolecules
Baochang Cheng, Yufei Yan, Jingjing Qi, Lianfu Deng, Zeng-Wu Shao, Ke-Qin Zhang, Bin Li, Ziling Sun, Xinming Li
Silk fibroin (SF) from Bombyx mori has received increasing interest in biomedical fields, because of its slow biodegradability, good biocompatibility, and low immunogenicity. Although SF based hydrogels have been studied intensively as potential matrix for tissue engineering, weak gelation performance and low mechanical strength are major limitations that hamper their widespread applicability. Therefore, searching for new strategies to improve SF gelation property is highly desirable in tissue engineering research...
March 27, 2018: ACS Applied Materials & Interfaces
Mojtaba Ghanbari Mehrabani, Ramin Karimian, Bahareh Mehramouz, Mahdi Rahimi, Hossein Samadi Kafil
One of the most serious challenge in wound care is difficulty of the infection control in wound healing process. Wound dressings with antimicrobial effects are useful to minimize the bacterial infections of wounds. In this study a biocompatible and biodegradable silk fibroin/chitin nanocomposite scaffolds with various content of silver nanoparticles (0.001, 0.01, and 0.1%) were fabricated via freeze-drying method for successful wound dressing application. The nanocomposite scaffolds have biocompatibility with high antimicrobial effects, good mechanical properties, and high porosity...
March 23, 2018: International Journal of Biological Macromolecules
Priyanka Choudhury, Satish Kumar, Abhishek Singh, Ashutosh Kumar, Navneet Kaur, Sridhar Sanyasi, Saurabh Chawla, Chandan Goswami, Luna Goswami
Patho-physiologies related to skin are diverse in nature such as burns, skin ulcers, atopic dermatitis, psoriasis etc. which impose severe bio-medical problems and thus enforce requirement of new and healthy skin prepared through tissues engineering methodologies. However, fully functional and biodegradable matrix for attachment, growth, proliferation and differentiation of the relevant cells is not available. In the present study, we introduce a set of hydrogels synthesized by incorporation of a synthetic monomer (Hydroxyethlmethacryate) with a semi-synthetic polymer backbone (carboxy methyl tamarind, CMT) in different mole ratios...
June 1, 2018: Carbohydrate Polymers
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