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Biodegradable scaffold

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https://www.readbyqxmd.com/read/28325683/biomimetic-scaffolds-with-three-dimensional-undulated-microtopographies
#1
Jonelle Z Yu, Emrullah Korkmaz, Monica I Berg, Philip R LeDuc, O Burak Ozdoganlar
Many human and animal tissues naturally possess three-dimensional (3D) micro-scale geometries enabling certain physiological functions. Absence of these microgeometries in engineered tissues may undermine the effectiveness of corresponding tissue repair and regeneration. This paper introduces a novel approach to create tissue scaffolds with biomimetic 3D undulated microtopographies. The mechanical micromilling technology is used for precise and reproducible fabrication of poly(methyl methacrylate) (PMMA) master molds with 3D undulated microtopographies...
February 14, 2017: Biomaterials
https://www.readbyqxmd.com/read/28325318/preparation-and-characterization-of-amine-functional-nano-hydroxyapatite-chitosan-bionanocomposite-for-bone-tissue-engineering-applications
#2
Besir Hakan Atak, Berna Buyuk, Merve Huysal, Sevim Isik, Mehmet Senel, Wolfgang Metzger, Guven Cetin
In this study, three different types of scaffolds including a uniquely modified composite scaffold - namely chitosan (CTS), nano-hydroxyapatite/chitosan composite (CTS+nHAP), and amine group (NH2) modified nano-hydroxyapatite/chitosan composite (CTS+nHAP-NH2) scaffolds - were synthesized for bone tissue engineering (BTE) purposes. As results of the study, it was found that all scaffold types were biodegradable with CTS and CTS+nHAP scaffolds losing up to 15% of their initial weight, while the CTS+nHAP-NH2 scaffold showing 10% of weight loss after six weeks of lysozyme treatment...
May 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28324641/preparation-of-a-non-woven-poly-%C3%AE%C2%B5-caprolactone-fabric-with-partially-embedded-apatite-surface-for-bone-tissue-engineering-applications-by-partial-surface-melting-of-poly-%C3%AE%C2%B5-caprolactone-fibers
#3
In Ae Kim, Sang-Hoon Rhee
This paper describes a novel method for the preparation of a biodegradable non-woven poly(ε-caprolactone) fabric with a partially-embedded apatite surface designed for application as a scaffold material for bone tissue engineering. The non-woven poly(ε-caprolactone) fabric was generated by the electro-spinning technique and then apatite was coated in simulated body fluid after coating the PVA solution containing CaCl2 ·2H2 O. The apatite crystals were partially- or fully-embedded into the thermoplastic poly(ε-caprolactone) fibers by controlling the degree of poly(ε-caprolactone) fiber surface melting in a convection oven...
March 21, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28296347/gdnf-schwann-cells-in-hydrogel-scaffolds-promote-regional-axon-regeneration-remyelination-and-functional-improvement-after-spinal-cord-transection-in-rats
#4
Bingkun K Chen, Nicolas N Madigan, Jeffrey S Hakim, Mahrokh Dadsetan, Siobhan S McMahon, Michael J Yaszemski, Anthony J Windebank
Positively-charged oligo[poly(ethylene glycol)fumarate] (OPF(+) ) is a biodegradable hydrogel used for spinal cord injury repair. We compared scaffolds containing primary Schwann cells (SCs) to scaffolds delivering SCs genetically modified to secrete high concentrations of glial cell-derived neurotrophic factor (GDNF). Multichannel OPF(+) scaffolds loaded with SCs or GDNF-SCs were implanted into transected rat spinal cords for 4 weeks. GDNF-SCs promoted regeneration of more axons into OPF(+) scaffolds (2773...
March 10, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28295800/self-rolled-porous-hollow-tubes-made-up-of-biodegradable-polymers
#5
Ling Peng, Jian Zhu, Seema Agarwal
A tubular highly porous scaffold of polylactide (PLA) and poly-ε-caprolactone (PCL) is fabricated by self-rolling of a 2D fibrous bilayer of PLA and PCL in water without use of any classical thermo-/pH-responsive polymers. The self-rolling and diameter of the tube are dependent upon the bilayer thickness and temperature. A 75 µm thick 2D bilayer (PLA = 25 µm; PCL = 50 µm) rolls to a hollow tube of diameter around 0.41 mm with multilayered wall at 40 °C within 5 min. The tubes keep their form and size in water at all temperatures once they are formed...
March 15, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28292602/investigation-of-human-dental-pulp-cells-on-a-potential-injectable-poly-lactic-co-glycolic-acid-microsphere-scaffold
#6
Huiru Zou, Guanhua Wang, Fang Song, Xudong Shi
INTRODUCTION: Poly(lactic-co-glycolic acid) (PLGA) has been extensively explored in the tissue engineering field with good biocompatibility and biodegradability. PLGA microspheres' injectable potency makes it highly desirable in dentin-pulp complex regeneration. Therefore, we investigated the cell adhesion, proliferation, odontogenic differentiation, and matrix mineralization of human dental pulp cells (HDPCs) on a PLGA microsphere scaffold. We hypothesized that this scaffold might be suitable for dentin-pulp complex regeneration...
March 11, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28290217/effect-of-volume-of-porogens-on-the-porosity-of-plga-scaffolds-in-ph-controlled-environment
#7
Manish Gupta, Adeyinka Aina, Yamina Boukari, Stephen Doughty, Andrew Morris, Nashiru Billa
Poly(lactic-co-glycolic acid) is a well-studied biodegradable polymer used in drug delivery and other medical applications such as in tissue regeneration. It is often necessary to impart porosity within the scaffold (microparticles) in order to promote the growth of tissue during the regeneration process. Sodium chloride and ammonium bicarbonate have been extensively used as porogens in the generation of porous microstructure. In this study we compared the effect of volumes (250 µl, 500 µl and 750 µl) of two porogens, sodium chloride (1...
March 14, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/28287033/marine-macromolecules-cross-linked-hydrogel-scaffolds-as-physiochemically-and-biologically-favorable-entities-for-tissue-engineering-applications
#8
Muraleedhara Kurup G, Sumayya A S
Marine biopolymer composite materials provide a technological platform for launching biomedical applications. Biomaterials demand good biocompatibility without the possibility of inflammation or foreign body reactions. In this study, we prepared two biocomposite hydrogels namely; HAC (hydroxyapatite, alginate & chitosan) and HACF (hydroxyapatite, alginate, chitosan & fucoidan) followed by calcium chloride cross linking. The prepared scaffolds were characterized by Fourier Transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM)...
March 11, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28286037/surface-enrichment-with-hydroxyapatite-nanoparticles-in-stereolithography-fabricated-composite-polymer-scaffolds-promotes-bone-repair
#9
O Guillaume, M A Geven, C M Sprecher, V A Stadelmann, D W Grijpma, T T Tang, L Qin, Y Lai, M Alini, J D de Bruijn, H Yuan, R G Richards, D Eglin
Fabrication of composite scaffolds using stereolithography (SLA) for bone tissue engineering has shown great promises. However, in order to trigger effective bone formation and implant integration, exogenous growth factors are commonly combined to scaffold materials. In this study, we fabricated biodegradable composite scaffolds using SLA and endowed them with osteopromotive properties in the absence of biologics. First we prepared photo-crosslinkable poly(trimethylene carbonate) (PTMC) resins containing 20 and 40 wt...
March 7, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28285078/biodegradable-inorganic-organic-hybrids-of-methacrylate-star-polymers-for-bone-regeneration
#10
Justin J Chung, Yuki Fujita, Siwei Li, Molly M Stevens, Toshihiro Kasuga, Theoni K Georgiou, Julian R Jones
Hybrids that are molecular scale co-networks of organic and inorganic components are promising biomaterials, improving the brittleness of bioactive glass and the strength of polymers. Methacrylate polymers have high potential as the organic source for hybrids since they can be produced, through controlled polymerization, with sophisticated polymer architectures that can bond to silicate networks. Previous studies showed the mechanical properties of hybrids can be modified by polymer architecture and molar mass (MM)...
March 8, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28283432/gentamicin-loaded-thermosetting-hydrogel-and-moldable-composite-scaffold-formulation-study-and-biologic-evaluation
#11
Rossella Dorati, Antonella De Trizio, Ida Genta, Alessia Merelli, Tiziana Modena, Bice Conti
The aim was to design biodegradable drug delivery systems for gentamicin local delivery, meanwhile acting as scaffold for bone regeneration. Gentamicin loaded thermosetting composite hydrogels (TCHG) were prepared combining chitosan with bovine bone substitutes (BBS Orthoss® granules), beta-glycerophosphate as crosslinker, and lyophilized to obtain composite moldable scaffolds (mCSG). Diverse techniques for gentamicin loading into mCS were investigated by drug incorporation during hydrogel preparation, or drug absorption on preformed mCS...
March 7, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28279644/elderly-patient-derived-endothelial-cells-for-vascularization-of-engineered-muscle
#12
Luba Perry, Moshe Y Flugelman, Shulamit Levenberg
In vitro prevascularization of engineered tissue constructs promises to enhance their clinical applicability. We hypothesize that adult endothelial cells (ECs), isolated from limb veins of elderly patients, bear the vasculogenic properties required to form vascular networks in vitro that can later integrate with the host vasculature upon implantation. Here, we show that adult ECs formed vessel networks that were more developed and complex than those formed by human umbilical vein endothelial cells (HUVECs) seeded with various supporting cells on three-dimensional (3D) biodegradable polymer scaffolds...
March 6, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28277009/nanofibrous-scaffold-from-electrospinning-biodegradable-waterborne-polyurethane-poly-vinyl-alcohol-for-tissue-engineering-application
#13
Yingke Wu, Weiwei Lin, Hongye Hao, Jiehua Li, Feng Luo, Hong Tan
A series of nanofibrous scaffolds, free of organic solvents, are prepared by electrospinning biodegradable waterborne polyurethane (BWPU) emulsion blending with aqueous poly(vinyl alcohol)(PVA). Tuning the proration of BWPU to PVA, various nanofibers with diameter from 370 to 964 nm are obtained. Strong intermolecular interaction existing between them benefits to the electrospun of BWPU emulsion, which is demonstrated by dynamic thermomechanical analysis and Fourier transform infrared spectroscopy. The nontoxic nanofibrous scaffolds with porous structure, which is similar to the natural extracellular matrix, favor to the attachment and proliferation of the L929 fibroblasts...
May 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28272494/an-innovative-approach-for-enhancing-bone-defect-healing-using-plga-scaffolds-seeded-with-extracorporeal-shock-wave-treated-bone-marrow-mesenchymal-stem-cells-bmscs
#14
Youbin Chen, Jiankun Xu, Zhonglian Huang, Menglei Yu, Yuantao Zhang, Hongjiang Chen, Zebin Ma, Haojie Liao, Jun Hu
Although great efforts are being made using growth factors and gene therapy, the repair of bone defects remains a major challenge in modern medicine that has resulted in an increased burden on both healthcare and the economy. Emerging tissue engineering techniques that use of combination of biodegradable poly-lactic-co-glycolic acid (PLGA) and mesenchymal stem cells have shed light on improving bone defect healing; however, additional growth factors are also required with these methods. Therefore, the development of novel and cost-effective approaches is of great importance...
March 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28271000/core-shell-nanofiber-characterization-by-raman-scanning-microscopy
#15
Lauren Sfakis, Anna Sharikova, David Tuschel, Felipe Xavier Costa, Melinda Larsen, Alexander Khmaladze, James Castracane
Core/shell nanofibers are becoming increasingly popular for applications in tissue engineering. Nanofibers alone provide surface topography and increased surface area that promote cellular attachment; however, core/shell nanofibers provide the versatility of incorporating two materials with different properties into one. Such synthetic materials can provide the mechanical and degradation properties required to make a construct that mimics in vivo tissue. Many variations of these fibers can be produced. The challenge lies in the ability to characterize and quantify these nanofibers post fabrication...
February 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28267318/modular-synthetic-approach-for-adjusting-the-disassembly-rates-of-enzyme-responsive-polymeric-micelles
#16
Assaf J Harnoy, Marina Buzhor, Einat Tirosh, Rona Shaharabani, Roy Beck, Roey J Amir
Self-assembled nanostructures and their stimuli-responsive degradation have been recently explored to meet the increasing need for advanced biocompatible and biodegradable materials for various biomedical applications. Incorporation of enzymes as triggers that can stimulate the degradation and disassembly of polymeric assemblies may be highly advantageous owing to their high selectivity and natural abundance in all living organisms. One of the key factors to consider when designing enzyme-responsive polymers is the ability to fine-tune the sensitivity of the platform toward its target enzyme in order to control the disassembly rate...
March 21, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28266598/treatment-of-rabbit-growth-plate-injuries-with-oriented-ecm-scaffold-and-autologous-bmscs
#17
Wenchao Li, Ruijiang Xu, Jiangxiang Huang, Xing Bao, Bin Zhao
Tissue-engineered technology has provided a promising method for the repair of growth plate injuries using biocompatible and biodegradable scaffolds and appropriate cells. The aim of this study was to fabricate oriented ECM scaffolds to imitate the material and structure of a natural growth plate and to investigate whether BMSCs in a scaffold could prevent the formation of bone bridges in an injured growth plate. We developed a natural, acellular and oriented scaffold derived from a growth plate. The oriented scaffold was fabricated using new freeze-drying technology and by cross-linking the microfilaments in the growth plate...
March 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28254317/personalized-plasma-based-medicine-to-treat-age-related-diseases
#18
REVIEW
Eduardo Anitua, María Troya, Mar Zalduendo, Gorka Orive
As social and health needs are changing, new challenges to develop innovative alternatives arise to address unmet medical needs. Personalized medicine is emerging as a promising and appealing therapeutic option. The use of patient's own plasma and platelets as therapeutics is providing new avenues in the treatment of acute and chronic tissue injuries by promoting tissue repair and regeneration. Plasma and platelet-based therapies mimic the physiological repair process by releasing autologous growth factors and creating a natural, biodegradable and transient scaffold that acts as transient matrix...
May 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28252933/lightweight-open-cell-scaffolds-from-sea-urchin-spines-with-superior-material-properties-for-bone-defect-repair
#19
Lei Cao, Xiaokang Li, Xiaoshu Zhou, Yong Li, Kenneth S Vecchio, Lina Yang, Wei Cui, Rui Yang, Yue Zhu, Zheng Guo, Xing Zhang
Sea urchin spines (Heterocentrotus mammillatus), with a hierarchical open-cell structure similar to that of human trabecular bone and superior mechanical property (compressive strength ∼43.4 MPa) suitable for machining to shape, were explored for potential applications of bone defect repair. Finite element analyses reveal that the compressive stress concentrates along the dense growth rings and dissipates through strut structures of the stereoms, indicating that the exquisite mesostructures play an important role in high strength-to-weight ratios...
March 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28249039/repair-of-critical-sized-cranial-defects-with-bmp9-transduced-calvarial-cells-delivered-in-a-thermoresponsive-scaffold
#20
Zari P Dumanian, Viktor Tollemar, Jixing Ye, Minpeng Lu, Yunxiao Zhu, Junyi Liao, Guillermo A Ameer, Tong-Chuan He, Russell R Reid
Large skeletal defects caused by trauma, congenital malformations, and post-oncologic resections of the calvarium present major challenges to the reconstructive surgeon. We previously identified BMP-9 as the most osteogenic BMP in vitro and in vivo. Here we sought to investigate the bone regenerative capacity of murine-derived calvarial mesenchymal progenitor cells (iCALs) transduced by BMP-9 in the context of healing critical-sized calvarial defects. To accomplish this, the transduced cells were delivered to the defect site within a thermoresponsive biodegradable scaffold consisting of poly(polyethylene glycol citrate-co-N-isopropylacrylamide mixed with gelatin (PPCN-g)...
2017: PloS One
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