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Endocrinology

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https://www.readbyqxmd.com/read/29141379/-clinical-value-of-tumor-size-in-the-evaluation-of-adrenal-incidentalomas
#1
L L Li, L Zhao, J T Dou, G Q Yang, W J Gu, Z H Lü, J M Ba, Y M Mu, J M Lu, C Y Pan
Objective: To investigate the clinical value of tumor size in the evaluation of endocrinological and histological natures regarding adrenal incidentaloma (AI) patients. Methods: A total of 1 941 AI patients who were hospitalized in Department of Endocrinology, Chinese PLA General Hospital between January 1997 and December 2016 were retrospectively reviewed. The demographics of patients, imaging features, functional status and histological results were analyzed. Results: Of 1 941 patients, 984 (50.70%) were males, and 957 (49...
November 14, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29138801/vitamin-d-receptor-activation-influences-the-erk-pathway-and-protects-against-neurological-deficits-and-neuronal-death
#2
Jie Yuan, Xin Guo, Zhengang Liu, Xiuqin Zhao, Yan Feng, Sixin Song, Changmeng Cui, Pei Jiang
Previous studies have demonstrated that global cerebral ischemia (GCI) causes neurological deficits and neuronal cell apoptosis. Calcitriol, a biologically active metabolite of vitamin D, exerts its endocrinological influence via nuclear vitamin D receptor. It is being assessed as an emerging therapeutic strategy in models of various medical conditions, including acute brain injury. The purpose of the present study was to investigate the neuroprotective effects of calcitriol on GCI and further refine the potential underlying mechanisms...
November 9, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29137042/associations-among-medication-regimen-complexity-medical-specialty-and-medication-possession-ratio-in-newly-diagnosed-hypertensive-patients-a-population-based-study
#3
Chen-Pei Ho, Jih-I Yeh, Shu-Hui Wen, Tony Jer-Fu Lee
The aim of this study was to explore the associations among the medication regimen complexity index (MRCI), medical specialty, and medication possession ratio (MPR) in newly diagnosed hypertensive patients.Data from 19,859 newly diagnosed hypertensive patients were collected from 2,000,000 random samples of the National Health Insurance Research Database in Taiwan. All study participants were followed for 1 year after the first diagnosis of hypertension. MPR was defined as total days of antihypertensive drugs supplied/365 days...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29134087/do-glucocorticoids-predict-fitness-linking-environmental-conditions-corticosterone-and-reproductive-success-in-the-blue-tit-cyanistes-caeruleus
#4
L J Henderson, N P Evans, B J Heidinger, K A Herborn, K E Arnold
Glucocorticoids, including corticosterone (CORT), have been suggested to provide a physiological link between ecological conditions and fitness. Specifically, CORT, which is elevated in response to harsh conditions, is predicted to be correlated with reduced fitness. Yet, empirical studies show that CORT can be non-significantly, positively and negatively linked with fitness. Divergent environmental conditions between years or study systems may influence whether CORT is linked to fitness. To test this, we monitored free-living blue tits (Cyanistes caeruleus) during breeding over 3 years...
October 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/29128250/sex-specific-hypothalamic-pituitary-gonadal-axis-sensitivity-in-migrating-songbirds
#5
Kristen M Covino, Jodie M Jawor, Sara R Morris, Frank R Moore
In seasonally migratory species, the overlap between the migratory and breeding life history stages is a balance between the physiological and behavioral requirements of each stage. Previous studies investigating the degree to which songbirds prepare for breeding during spring migration have focused on either circulating hormone levels or direct measures of gonadal recrudescence. In this study, we evaluated the phenology of breeding preparation in a long-distance migratory songbird, the Swainson's Thrush (Catharus ustulatus), by assessing hypothalamic-pituitary-gonadal (HPG) axis sensitivity with gonadotropin-releasing hormone (GnRH) bioassays throughout the migratory period...
November 8, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/29127766/etiologies-of-short-stature-in-a-pediatric-endocrine-clinic-in-southern-thailand
#6
Tansit Saengkaew, Edward McNeil, Somchit Jaruratanasirikul
BACKGROUND: Short stature is one of the common disorders referred for investigation of an endocrine disorder. The etiologies of short stature vary and are commonly grouped into pathological and non-pathological disorders. The objective of the study was to determine the etiologies and describe the characteristics of short stature patients who attended the Pediatric Endocrinology Clinic and to compare factors between normal variant short stature (NVSS) and growth hormone deficiency (GHD)...
November 11, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29125446/suprasellar-and-recurrent-pediatric-craniopharyngiomas-expanding-indications-for-the-extended-endoscopic-transsphenoidal-approach
#7
Andrew F Alalade, Elizabeth Ogando-Rivas, Jerome Boatey, Mark M Souweidane, Vijay K Anand, Jeffrey P Greenfield, Theodore H Schwartz
OBJECTIVE The expanded endonasal endoscopic transsphenoidal approach has become increasingly used for craniopharyngioma surgery in the pediatric population, but questions still persist regarding its utility in younger children, in recurrent and irradiated tumors, and in masses primarily located in the suprasellar region. The narrow corridor, incomplete pneumatization, and fear of hypothalamic injury have traditionally relegated this approach to application in older children with mostly cystic craniopharyngiomas centered in the sella...
November 10, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29124666/study-design-and-evaluation-of-risk-minimization-measures-a-review-of-studies-submitted-to-the-european-medicines-agency-for-cardiovascular-endocrinology-and-metabolic-drugs
#8
Giampiero Mazzaglia, Sabine M J Straus, Peter Arlett, Daniela da Silva, Heidi Janssen, June Raine, Enrica Alteri
INTRODUCTION: Studies measuring the effectiveness of risk minimization measures (RMMs) submitted by pharmaceutical companies to the European Medicines Agency are part of the post-authorization regulatory requirements and represent an important source of data covering a range of medicinal products and safety-related issues. Their objectives, design, and the associated regulatory outcomes were reviewed, and conclusions were drawn that may support future progress in risk minimization evaluation...
November 9, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/29123009/new-challenges-in-nuclear-endocrinology
#9
David Taieb, Rodney Hicks, Karel Pacak
No abstract text is available yet for this article.
November 9, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29122740/the-perceptions-of-medical-school-students-and-faculty-toward-obesity-medicine-education-survey-and-needs-analysis
#10
Mary Metcalf, Karen Rossie, Katie Stokes, Bradley Tanner
BACKGROUND: Recent trends in obesity show that over two-thirds of US adults are considered at least overweight (body mass index, BMI≥25 kg/m(2)) and of those, about one-third are categorized as obese (BMI≥30 kg/m(2)). Physicians can address the health impacts of obesity; yet research has suggested that physicians-in-training frequently fail to recognize obesity, are not properly educated regarding treatment options, and spend relatively little clinic time treating obesity. Medical school is a unique opportunity to address this area of need so that the doctors of tomorrow are prepared to treat obesity appropriately...
November 9, 2017: JMIR Medical Education
https://www.readbyqxmd.com/read/29122303/is-it-really-possible-to-predict-the-consistency-of-a-pituitary-adenoma-preoperatively
#11
A K Thotakura, M R Patibandla, M K Panigrahi, A Mahadevan
OBJECTIVES: To determine if the consistency of pituitary adenomas can be predicted based on a preoperative MRI study and to assess the surgical outcome of firm pituitary adenomas. MATERIALS AND METHODS: One hundred consecutive patients with pituitary adenomas and suprasellar extension were operated by a transsphenoidal approach from July 2003 to December 2006. In addition to the neurological examination, the patients were evaluated by ophthalmological, endocrinological and radiological workups...
November 6, 2017: Neuro-Chirurgie
https://www.readbyqxmd.com/read/29121256/malignant-testicular-germ-cell-tumors-in-postpubertal-individuals-with-androgen-insensitivity-prevalence-pathology-and-relevance-of-single-nucleotide-polymorphism-based-susceptibility-profiling
#12
M Cools, K P Wolffenbuttel, R Hersmus, B B Mendonca, J Kaprová, S L S Drop, H Stoop, A J M Gillis, J W Oosterhuis, E M F Costa, S Domenice, M Y Nishi, L Wunsch, C A Quigley, G T'Sjoen, L H J Looijenga
STUDY QUESTION: What is the prevalence of malignant testicular germ cell tumors (TGCT) and its precursors, (pre-) germ cell neoplasia in situ (GCNIS), in late teenagers and adults who have androgen insensitivity syndrome (AIS) and the impact of an individual's genetic susceptibility to development of TGCT? SUMMARY ANSWER: No GCNIS or TGCT was diagnosed, but pre-GCNIS was identified in 14 and 10% of complete and partial AIS patients, respectively, and was associated with a higher genetic susceptibility score (GSS), with special attention for KITLG (rs995030) and ATFZIP (rs2900333)...
November 7, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29120925/noonan-syndrome-an-update-on-growth-and-development
#13
Armelle Yart, Thomas Edouard
PURPOSE OF REVIEW: To provide an update on recent developments on Noonan syndrome with a special focus on endocrinology, bone, and metabolism aspects. The key issues still to be resolved and the future therapeutic perspectives will be discussed. RECENT FINDINGS: The discovery of the molecular genetic causes of Noonan syndrome and Noonan-syndrome-related disorders has permitted us to better understand the mechanisms underlying the different symptoms of these diseases and to establish genotype-phenotype correlations (in growth patterns for example)...
November 7, 2017: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/29120649/-thyroid-disease-in-the-czech-republic-the-euthyroid-project-and-the-evaluation-of-the-general-health-insurance-company-epidemiological-data-for-the-period-of-2012-2015
#14
Radovan Bílek, Lenka Horáková, Robert Goš, Václav Zamrazil
Institute of Endocrinology participates in the grant of European Commission EUthyroid (Towards the elimination of iodine deficiency and preventable thyroid-related diseases in Europe), together with other 28 European countries. The role of Institute of Endocrinology in EUthyroid is among other things to ensure access to national registers relating to thyroid diseases. The results presented here correspond to the years 2012-2015 and are based on data from the General Health Insurance Company Czech Republic (VZP CR), which has 6 million insured persons (ratio male : female = 1 : 1)...
2017: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29118987/massive-adrenal-incidentalomas-and-late-diagnosis-of-congenital-adrenal-hyperplasia-in-prostate-cancer
#15
Xin Feng, Gregory Kline
In a 61-year-old Caucasian male with prostate cancer, leuprolide and bicalutamide failed to suppress the androgens. He presented to endocrinology with persistently normal testosterone and incidental massive (up to 18 cm) bilateral adrenal myelolipomas on CT scan. Blood test did not reveal metanephrine excess. The patient was noted to have short stature (151 cm) and primary infertility. Elementary school photographs demonstrated precocious puberty. Physical examination revealed palpable abdominal (adrenal) masses...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29118982/uneven-distribution-of-professors-and-instructors-in-medical-disciplines-dealing-with-the-four-main-chronic-non-communicable-diseases-the-case-of-the-italian-universities
#16
Giovanni Viegi, Stefano Centanni, Francesco Blasi
Background: Chronic (non-communicable) diseases (NCD) -- principally cardiovascular diseases, cancer, chronic respiratory diseases, and diabetes -- are leading causes of death and disability. There is the need to adopt a core University curriculum which let students be taught by teachers who are experts of the four main NCD, for reaching the public health goals proposed by the UN and the WHO. Methods: Our aim was to assess whether all medical students, regardless of the Italian university of enrolment, have an equal opportunity to be educated by an expert teacher in each of the four NCD...
2017: Multidisciplinary Respiratory Medicine
https://www.readbyqxmd.com/read/29117664/pituitary-abscess-with-unusual-clinical-course
#17
Milica Medić Stojanoska, Duško Kozić, Mladen Bjelan, Petar Vuleković, Nada Vučković, Bojan Vuković, Branka Kovačev Zavišić
The aim is to present unusual clinical course and magnetic resonance imaging (MRI) features of pituitary abscess. A 59-year-old man presented with fever, polyuria, polydipsia and marked weight loss within the last two months. Basic endocrinology tests revealed the presence of anterior pituitary dysfunction, associated with central diabetes insipidus and increased levels of inflammatory markers. The presence of expansile sellar lesion, showing restricted diffusion signal pattern compatible with acute pituitary pyogenic abscess was found on MRI...
December 2016: Acta Clinica Croatica
https://www.readbyqxmd.com/read/29114265/dehydroepiandrosterone-sulfate-insulin-resistance-and-ovarian-volume-estimation-in-patients-with-polycystic-ovarian-syndrome
#18
Chrysi Christodoulaki, Eftihios Trakakis, Vasilios Pergialiotis, Periklis Panagopoulos, Charalampos Chrelias, Dimitrios Kassanos, Dimos Sioutis, Nikolaos Papantoniou, Dimitrios Xirofotos
Objective: To investigate the potential association of DHEA-S with metabolic and hormonal alterations and with disorders of ovarian morphology. Materials and methods: The present study was based on women with PCOS that attended the Gynaecological Endocrinology - Paediatric and Adolescence Endocrinology Department of our clinic. Overall, 321 patients who met the Rotterdam ESHRE/ ASRM - Sponsored criteria for the definition of PCOS were included. Women's personal medical history was recorded, anthropometric parameters were assessed and blood was drawn for analysis of metabolic and hormonal parameters...
March 2017: Journal of Family & Reproductive Health
https://www.readbyqxmd.com/read/29107959/sleep-quality-and-health-related-quality-of-life-among-long-term-survivors-of-non-hodgkin-lymphoma-in-germany
#19
Friederike Hammersen, Philip Lewin, Judith Gebauer, Ilonka Kreitschmann-Andermahr, Georg Brabant, Alexander Katalinic, Annika Waldmann
This study investigated sleep quality and health-related quality of life (HRQOL) among long-term survivors of Hodgkin (HL) and non-Hodgkin lymphoma (NHL). The aim was to explore the impact of personal and health-related factors on sleep quality as well as associations between sleep quality and HRQOL. For the postal survey, participants with a minimum age of 18 years initially treated between 1998 and 2008 were recruited via the population-based cancer registry in Schleswig-Holstein, Northern Germany. Questionnaires included amongst others the Pittsburg Sleep Quality Index (PSQI) and the 36-Item Short Form Health Survey (SF-36v1)...
2017: PloS One
https://www.readbyqxmd.com/read/29100890/molecular-endocrinology-of-female-reproductive-behavior
#20
REVIEW
D W Pfaff, K Gagnidze, R G Hunter
Epigenetic methodologies address mechanisms of estrogenic effects on hypothalamic and preoptic neurons, as well as mechanisms by which stress can interfere with female reproductive behaviors. Recent results are reviewed.
October 31, 2017: Molecular and Cellular Endocrinology
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