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https://www.readbyqxmd.com/read/29656619/impact-of-resident-involvement-in-neurosurgery-an-american-college-of-surgeons-national-surgical-quality-improvement-program-database-analysis-of-33-977-patients
#1
Andreea Seicean, Prateek Kumar, Sinziana Seicean, Duncan Neuhauser, Warren R Selman, Nicholas C Bambakidis
OBJECTIVE: There is conflicting and limited literature on the effect of intraoperative resident involvement on surgical outcomes. Our study assessed effects of resident involvement on outcomes in patients undergoing neurosurgery. METHODS: We identified 33,977 adult neurosurgical cases from 374 hospitals in the 2006-2012 National Surgical Quality Improvement Program, a prospectively collected national database with established reproducibility and validity. Outcomes were compared according to resident involvement before and after 1:1 matching on procedure and perioperative risk factors...
March 2018: Neurospine
https://www.readbyqxmd.com/read/29656613/sirna-modified-with-2-deoxy-2-c-methylpyrimidine-nucleosides
#2
Maria Dellafiore, Anna Aviñó, Adele Alagia, Javier M Montserrat, Adolfo Marcelo Iribarren, Ramón Eritja
(2'S)-2'-Deoxy-2'-C-methyluridine and (2'R)-2'-deoxy-2'-C-methyluridine were incorporated in the 3'-overhang region of the sense and antisense strands and in positions 2- and 5- of the seed region of siRNA duplexes directed against Renilla luciferase, while (2'S)-2'-deoxy-2'-C-methylcytidine was incorporated in the 6- position of the seed region of the same constructions. Dual luciferase reporter assay in transfected HeLa cells was used as model system to measure IC50 values of 24 different modified duplexes...
April 14, 2018: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/29656609/monocyte-function-in-patients-with-myelodysplastic-syndrome
#3
Daniel A Pollyea, Brenna R Hedin, Brian P O'Connor, Scott Alper
Myelodysplastic syndrome (MDS) is a malignant hematopoietic stem cell disorder that frequently evolves into acute myeloid leukemia (AML). Patients with MDS are prone to infectious complications, in part due to the presence of severe neutropenia and/or neutrophil dysfunction. However, not all patients with neutropenia become infected, suggesting that other immune cells may compensate in these patients. Monocytes are also integral to immunologic defense; however, much less is known about monocyte function in patients with MDS...
April 14, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29656608/combined-therapy-for-critical-limb-ischemia-biomimetic-plga-microcarriers-potentiates-the-pro-angiogenic-effect-of-adipose-tissue-stromal-vascular-fraction-cells
#4
Laurence Hoareau, Florian Fouchet, Cynthia Planesse, Sophie Mirbeau, Laurence Sindji, Emmanuel Delay, Régis Roche, Claudia N Montero-Menei, Franck Festy
We propose a regenerative solution in the treatment of critical limb ischemia. Poly-lactic/glycolic acid (PLGA) microcarriers were prepared and coated with laminin to be sterilized through γ-irradiation of 25 kGy at low temperature. Stromal vascular fraction (SVF) cells were extracted through enzymatic digestion of adipose tissue. Streptozotocin-induced diabetic mice underwent arteriotomy and received an administration of SVF cells combined or not with biomimetic microcarriers. Functional evaluation of the ischemic limb was then reported and tissue reperfusion was evaluated through fluorescence molecular tomography (FMT)...
April 14, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29656606/a-meta-analysis-on-the-surgical-management-of-paraganglioma-of-the-carotid-body-per-shamblin-class
#5
Thijs T G Jansen, Henri A M Marres, Johannes H A M Kaanders, Henricus P M Kunst
OBJECTIVE: The aim of the current study is to evaluate the risk associated with different types of surgery for carotid body paraganglioma of different Shamblin class. A meta-analysis was conducted to evaluate per tumour class, the local control, cranial nerve damage and complication rates of different techniques using internal carotid artery (ICA) and external carotid artery (ECA) ligation, clamping or bypassing, as well as the cranio-caudal versus caudo-cranial techniques. DESIGN: A meta-analysis is conducted after a systematic search in PubMed and the Cochrane library, in accordance with the PRISMA guidelines...
April 15, 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29656600/long-term-efficacy-and-safety-of-sucroferric-oxyhydroxide-in-african-american-dialysis-patients
#6
Stuart M Sprague, Markus Ketteler, Adrian C Covic, Jürgen Floege, Viatcheslav Rakov, Sebastian Walpen, Anjay Rastogi
INTRODUCTION: Sucroferric oxyhydroxide (SFOH) is a non-calcium, iron-based phosphate binder that demonstrated sustained serum phosphorus (sP) control, good tolerability, and lower pill burden, vs. sevelamer carbonate ("sevelamer"), in a Phase 3 study conducted in dialysis patients with hyperphosphatemia. This analysis evaluates the efficacy and safety of SFOH and sevelamer among African American (AA) patients participating in the trial. METHODS: Post hoc analysis of a 24-week, Phase 3, open-label trial (NCT01324128) and its 28-week extension study (NCT01464190)...
April 15, 2018: Hemodialysis International
https://www.readbyqxmd.com/read/29656588/the-use-of-funnel-plots-with-regression-as-a-tool-to-visually-compare-hiv-treatment-outcomes-between-centres-adjusting-for-patient-characteristics-and-size-a-uk-collaborative-hiv-cohort-study
#7
M Gompels, S Michael, S Jose, T Hill, R Trevelion, C A Sabin, M T May
OBJECTIVES: A measure used for assessing the effectiveness of HIV care and comparing clinical centres is the proportion of people starting antiretroviral therapy (ART) with viral suppression (VS) after 1 year. We propose a method that adjusts for patients' demographic characteristics, and visually compares this measure between different sites accounting for centre size. METHODS: We analysed viral load measurements for UK Collaborative HIV Cohort (UK CHIC) patients starting ART between 2006 and 2013...
April 14, 2018: HIV Medicine
https://www.readbyqxmd.com/read/29656582/hyperactive-cyclic-motor-activity-in-the-distal-colon-after-colonic-surgery-as-defined-by-high-resolution-colonic-manometry
#8
R Vather, G O'Grady, A Y Lin, P Du, C I Wells, D Rowbotham, J Arkwright, L K Cheng, P G Dinning, I P Bissett
BACKGROUND: Recovery after colonic surgery is invariably delayed by disturbed gut motility. It is commonly assumed that colonic motility becomes quiescent after surgery, but this hypothesis has not been evaluated rigorously. This study quantified colonic motility through the early postoperative period using high-resolution colonic manometry. METHODS: Fibre-optic colonic manometry was performed continuously before, during and after surgery in the left colon and rectum of patients undergoing right hemicolectomy, and in healthy controls...
April 14, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29656568/nanofiber-based-hydrogels-controllable-synthesis-and-multifunctional-applications
#9
REVIEW
Qiuxia Fu, Cheng Duan, Zishuo Yan, Yan Li, Yang Si, Lifang Liu, Jianyong Yu, Bin Ding
Nanofiber-based hydrogels (NFHGs) prepared by the combination of traditional hydrogels and novel nanofibers have demonstrated great potential in various application fields, owing to their integrated advantages of superhydrophilicity, high water-holding capacity, good biocompatibility, enhanced mechanical strength, and excellent structural tenability. In this review, a comprehensive overview of the structure design and synthetic strategy of NFHGs derived from electrospinning technique, weaving, freeze-drying, 3D printing, and molecular self-assembling method is provided...
April 14, 2018: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/29656566/absence-of-human-skin-irritation-and-allergenic-potential-after-repeated-patch-applications-of-a-lamellar-moisturizer
#10
Stephanie J Nisbet
BACKGROUND: New cosmetic products should undergo clinical evaluation for skin sensitization potential. OBJECTIVES: To assess the irritation and sensitization potential of a moisturizer containing lamellar structured lipids after repeated patch application in humans, using human repeated insult patch test methodology. METHODS: This 6-week, single-center, open-label study compared a lamellar moisturizer with negative saline control in human subjects aged 18-70 years and skin phototype (Fitzpatrick) classification I-IV...
April 15, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29656564/picophytoplankton-size-and-biomass-around-equatorial-eastern-indian-ocean
#11
Yuqiu Wei, Jun Sun, Xiaodong Zhang, Jing Wang, Ke Huang
The cellular size and biomass of picophytoplankton were studied by flow cytometer during spring monsoon (March-May of 2015) in equatorial eastern Indian Ocean. We established an empirical relationship between forward scatter and cellular size to address the size and biomass of picophytoplankton. Results indicated that mean cell diameter of Prochlorococcus (0.60 μm) was the smallest, and then followed by Synechococcus (0.98 μm) and picoeukaryotic phytoplankton (1.05 μm). Thereafter, the biomass converted by abundance reached 0...
April 15, 2018: MicrobiologyOpen
https://www.readbyqxmd.com/read/29656561/advances-in-controlling-differentiation-of-adult-stem-cells-for-peripheral-nerve-regeneration
#12
REVIEW
Metin Uz, Suprem R Das, Shaowei Ding, Donald S Sakaguchi, Jonathan C Claussen, Surya K Mallapragada
Adult stems cells, possessing the ability to grow, migrate, proliferate, and transdifferentiate into various specific phenotypes, constitute a great asset for peripheral nerve regeneration. Adult stem cells' ability to undergo transdifferentiation is sensitive to various cell-to-cell interactions and external stimuli involving interactions with physical, mechanical, and chemical cues within their microenvironment. Various studies have employed different techniques for transdifferentiating adult stem cells from distinct sources into specific lineages (e...
April 14, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29656554/a-single-day-of-bed-rest-irrespective-of-energy-balance-does-not-affect-skeletal-muscle-gene-expression-or-insulin-sensitivity
#13
Marlou L Dirks, Francis B Stephens, Sarah R Jackman, Jesús Galera Gordo, David Machin, Richard M Pulsford, Luc Jc van Loon, Benjamin T Wall
NEW FINDINGS: What is the central question of this study? What are the initial metabolic and molecular events that underpin bed rest-induced skeletal muscle deconditioning, and what is the contribution of energy balance? What is the main finding and its importance? A single day of bed rest, irrespective of energy balance, did not lead to overt changes in skeletal muscle gene expression or insulin sensitivity. More than one day of physical inactivity is required to observe the insulin resistance and robust skeletal muscle transcriptional responses associated with bed rest and consequent alterations in energy balance...
April 15, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29656551/efficacy-of-three-different-steamers-for-control-of-bed-bugs-cimex-lectularius-l
#14
Desen Wang, Changlu Wang, Guohong Wang, Chen Zha, Amanda L Eiden, Richard Cooper
BACKGROUND: Bed bugs, Cimex lectularius L., have become one of the most difficult urban pests to control. Steam treatment is reported to be an effective method to kill bed bugs and is considered to be an important component of bed bug integrated pest management (IPM). We evaluated and compared the efficacy of two affordable consumer-grade commercial steamers to a commonly used professional-grade steamer for killing bed bugs. RESULTS: In laboratory experiments, the consumer-grade steamer at an affordable price achieved the same high control efficacy as the professional-grade steamer for treating bed bugs exposed on mattresses (100% bed bug mortality), located beneath a fabric cover (>89% bed bug mortality), or hiding in cracks (100% bed bug mortality)...
April 15, 2018: Pest Management Science
https://www.readbyqxmd.com/read/29656531/post-traumatic-stress-disorder-and-risk-of-osteoporosis-a-nationwide-longitudinal-study
#15
Wei-Sheng Huang, Ju-Wei Hsu, Kai-Lin Huang, Ya-Mei Bai, Tung-Ping Su, Cheng-Ta Li, Wei-Chen Lin, Tzeng-Ji Chen, Shih-Jen Tsai, Ying-Jay Liou, Mu-Hong Chen
Several studies suggested a relationship between stress and related mental illnesses, such as depression and osteoporosis. However, it was unclear whether patients with post-traumatic stress disorder (PTSD) were at risk of developing osteoporosis in later life. In this study, 6,041 patients with PTSD and 24,164 age- or sex-matched controls were enrolled between 2002 and 2009 in our study and followed up to the end of 2011. Cases of osteoporosis were identified during the follow-up. Patients with PTSD had an elevated likelihood of developing osteoporosis (HR: 2...
April 15, 2018: Stress and Health: Journal of the International Society for the Investigation of Stress
https://www.readbyqxmd.com/read/29656517/a-color-tunable-fluorescent-supramolecular-hyperbranched-polymer-constructed-by-pillar-5-arene-based-host-guest-recognition-and-metal-ion-coordination-interaction
#16
Hui Li, Wenzhuo Chen, Fenfen Xu, Xiaodong Fan, Tongxiang Liang, Xiaopeng Qi, Wei Tian
Fluorescent supramolecular polymers are an important kind of smart material. In this work, a new fluorescent supramolecular hyperbranched polymer (FSHP) is constructed by orthogonal self-assembly: pillararene-based host-guest interaction and metal ion complexation interaction. The FSHP exhibits concentration-controllable fluorescence emissions. The photoluminescence spectra and light-emitting colors of FSHP can be effectively tuned by changing metal ion types or using mixed metal ions. The fluorescence quenching of FSHP solutions or FSHP-based films would occur when removing the metal ions from the backbone of FSHP...
April 14, 2018: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/29656515/comparative-cyp-omic-analysis-between-the-ddt-susceptible-and-resistant-drosophila-melanogaster-strains-91-c-and-91-r
#17
Keon Mook Seong, Brad S Coates, May R Berenbaum, John M Clark, Barry R Pittendrigh
BACKGROUND: Cytochrome P450 monooxygenases (P450s) are involved in the biosynthesis of endogenous intracellular compounds and the metabolism of xenobiotics, including chemical insecticides. We investigated the structural and expression level variance across all P450 genes with respect to the evolution of insecticide resistance under multigenerational DDT selection. RESULTS: RNA-seq and reverse transcriptase quantitative PCR indicated that the transcript levels of seven P450 genes were significantly up-regulated and three P450 genes were down-regulated in the DDT-resistant strain 91-R, as compared to the control strain 91-C...
April 15, 2018: Pest Management Science
https://www.readbyqxmd.com/read/29656509/melioration-revisited-a-systematic-replication-of-vaughan-1981
#18
Vikki J Bland, Sarah Cowie, Douglas Elliffe, Christopher A Podlesnik
Organisms that behave so as to forfeit a relatively higher overall rate of reinforcement in favor of a relatively lower rate are said to engage in suboptimal choice. Suboptimal choice has been linked with maladaptive behavior in humans. Melioration theory offers one explanatory framework for suboptimal choice. Melioration theory suggests behavior is controlled by differences in local reinforcer rates between alternatives. Vaughan (1981) arranged two experimental conditions in which maximizing the overall rate of reinforcement required behavior that was compatible, or incompatible, with melioration...
April 15, 2018: Journal of the Experimental Analysis of Behavior
https://www.readbyqxmd.com/read/29656508/the-3-rd-world-conference-on-kisspeptin-kisspeptin-2017-brain-and-beyond-unresolved-questions-challenges-and-future-directions-for-the-field
#19
REVIEW
Michael N Lehman, Lique M Coolen, Robert A Steiner, Genevieve Neal-Perry, Luhong Wang, Suzanne M Moenter, Aleisha M Moore, Robert L Goodman, Shel Hwa-Yeo, Stephanie L Padilla, Alexander S Kauffman, James Garcia, Martin J Kelly, Jenny Clarkson, Sally Radovick, Andy V Babwah, Silvia Leon, Manuel Tena-Sempere, Alex Comninos, Stephanie Seminara, Waljit S Dhillo, Jon Levine, Ei Terasawa, Ariel Negron, Allan E Herbison
The 3rd World Conference on Kisspeptin, "Kisspeptin 2017: Brain and Beyond" was held March 30-31 at the Rosen Centre Hotel in Orlando, Florida, providing an international forum for multidisciplinary scientists to meet and share cutting-edge research on kisspeptin biology and its relevance to human health and disease. The meeting built upon previous world conferences focused on the role of kisspeptin and associated peptides in the control of gonadotropin-releasing hormone (GnRH) secretion and reproduction...
April 14, 2018: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29656507/construction-and-application-of-a-xanthomonas-campestris-cgmcc15155-strain-that-produces-white-xanthan-gum
#20
Xiaohui Dai, Ge Gao, Mengmeng Wu, Weiying Wei, Jianmei Qu, Guoqiang Li, Ting Ma
In the industrial production of xanthan gum using Xanthomonas campestris CGMCC15155, large amounts of ethanol are required to extract xanthan gum from the fermentation broth and remove xanthomonadin impurities. To reduce the amount of ethanol and the overall production cost of xanthan gum, a xanthomonadin-deficient strain of CGMCC15155 was constructed by inserting the Vitreoscilla globin (vgb) gene, under the control of the LacZ promoter, into the region of the pigA gene, which is involved in xanthomonadin synthesis...
April 15, 2018: MicrobiologyOpen
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