keyword
https://read.qxmd.com/read/38533001/waist-to-height-ratio-is-a-better-predictor-of-hypertension-in-women-during-recovery-from-anesthesia-compared-to-bmi-waist-to-hip-ratio-and-waist-circumference
#1
JOURNAL ARTICLE
Qinqin Cao, Chengjuan Fan, Yufen Fei, Shouxin Zhang, Tong Shen, Haihong Meng
This was an observational study of patients with benign breast tumors intended to investigate and compare the predictive value of body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), and waist-to-height ratio (WHtR) for hypertension in the recovery room. Logistic regression analysis was used to determine the association between these body fat anthropometric indices and hypertension. Receiver operating characteristic curve (ROC) analysis was performed to assess the comparative predictive ability...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38530804/senescent-adipocytes-and-type-2-diabetes-current-knowledge-and-perspective-concepts
#2
REVIEW
Weronika Kruczkowska, Julia Gałęziewska, Mateusz Kciuk, Adrianna Gielecińska, Elżbieta Płuciennik, Zbigniew Pasieka, Lin-Yong Zhao, Yi-Jin Yu, Damian Kołat, Żaneta Kałuzińska-Kołat
Among civilization diseases, the number of individuals suffering from type 2 diabetes (T2DM) is expected to increase to more than a billion in less than 20 years, which is associated with, e.g., populational aging, poor diet, sedentary lifestyle, genetic predispositions, and immunological factors. T2DM affects many organs and is characterized by insulin resistance, high glucose levels, and adipocyte dysfunction, which are related to senescence. Although this type of cellular aging has beneficial biological functions, it can also act unfavorable since senescent adipocytes resist apoptosis, enhance cytokine secretion, downregulate cell identity genes, and acquire the senescence-associated secretory phenotype that renders a more oxidative environment...
January 1, 2024: Biomolecular Concepts
https://read.qxmd.com/read/38514577/effect-of-preservation-of-hoffa-s-fat-pad-on-patellar-height-in-primary-total-knee-arthroplasty-procedures
#3
JOURNAL ARTICLE
Abdelaleem Ragab, Rhodri Gwyn, Andrew Davies
BACKGROUND: We have previously reported our experience of the effect of complete excision of Hoffa's fat pad on patella height post TKR. In this study, we compared the change of patellar height post TKR before and after the senior author changed his practice to preserving Hoffa's fat pad. METHODS: This was a retrospective analysis of a prospective series of TKRs performed or directly supervised by the senior author. In Group 1 were 72 patients performed before April 2011 who had complete excision of Hoffa's fat pad to maximise exposure during the procedure...
March 22, 2024: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://read.qxmd.com/read/38512802/determining-the-hierarchical-order-by-which-intestinal-tract-administered-diet-and-individual-relay-can-shape-the-gut-microbiome-of-fattening-quails
#4
JOURNAL ARTICLE
Giovanni Bertoldo, Chiara Broccanello, Alessandra Tondello, Silvia Cappellozza, Alessio Saviane, Attawit Kovitvadhi, Giuseppe Concheri, Marco Cullere, Piergiorgio Stevanato, Antonella Dalle Zotte, Andrea Squartini
A bacterial metabarcoding approach was used to compare the microbiome composition of caecal and faecal samples from fattening Japanese quails (Coturnix coturnix japonica) fed three different diet regimes. The tested feedstuffs included (1) a commercial diet for fattening quails, (2) a commercial diet containing 12% full-fat silkworm (Bombyx mori) pupae meal, and (3) a commercial diet containing 12% defatted silkworm pupae meal. The aim of the experiment was to verify the relative effect of three variables (diet type, gut tract comparing caecum to rectum, and individual animal) in determining the level of bacterial community dissimilarity to rank the relevance of each of the three factors in affecting and shaping community composition...
2024: PloS One
https://read.qxmd.com/read/38502074/aspirin-for-metabolic-dysfunction-associated-steatotic-liver-disease-without-cirrhosis-a-randomized-clinical-trial
#5
RANDOMIZED CONTROLLED TRIAL
Tracey G Simon, Robert M Wilechansky, Stefania Stoyanova, Alessandra Grossman, Laura E Dichtel, Georg M Lauer, Karen K Miller, Yujin Hoshida, Kathleen E Corey, Rohit Loomba, Raymond T Chung, Andrew T Chan
IMPORTANCE: Aspirin may reduce severity of metabolic dysfunction-associated steatotic liver disease (MASLD) and lower the incidence of end-stage liver disease and hepatocellular carcinoma, in patients with MASLD. However, the effect of aspirin on MASLD is unknown. OBJECTIVE: To test whether low-dose aspirin reduces liver fat content, compared with placebo, in adults with MASLD. DESIGN, SETTING, AND PARTICIPANTS: This 6-month, phase 2, randomized, double-blind, placebo-controlled clinical trial was conducted at a single hospital in Boston, Massachusetts...
March 19, 2024: JAMA
https://read.qxmd.com/read/38472858/a-comprehensive-review-of-cured-meat-products-in-the-irish-market-opportunities-for-reformulation-and-processing
#6
REVIEW
Jan Roland G Molina, Jesús M Frías-Celayeta, Declan J Bolton, Cristina Botinestean
Cured meat products constitute one of the meat categories commonly consumed in Ireland and has been part of the Irish cuisine and diet for many years. Ham, gammon, and bacon are some of the products that involve curing as part of the traditional processing methods. Common among these products are high levels of salt and the addition of nitrites. These products undergo processing treatments to create variety, preserve shelf-life, and develop their unique quality and safety characteristics. However, consumers are becoming more conscious of the level of processing involved in these products, and the effects of some components and ingredients might be perceived as unhealthy...
February 28, 2024: Foods (Basel, Switzerland)
https://read.qxmd.com/read/38467191/endothelial-slc35a1-deficiency-causes-loss-of-lsec-identity-and-exacerbates-neonatal-lipid-deposition-in-the-liver-in-mice
#7
JOURNAL ARTICLE
Bin Zuo, Fei Yang, Lulu Huang, Jingjing Han, Tianyi Li, Zhenni Ma, Lijuan Cao, Yun Li, Xia Bai, Miao Jiang, Yang He, Lijun Xia
BACKGROUND & AIMS: The functional maturation of the liver largely occurs after birth. In the early stages of life, the liver of a newborn encounters enormous high-fat metabolic stress caused by the consumption of breast milk. It is unclear how the maturing liver adapts to high lipid metabolism. Liver sinusoidal endothelial cells (LSECs) play a fundamental role in establishing liver vasculature and are decorated with many glycoproteins on their surface. The Slc35a1 gene encodes a CMP-sialic acid transporter responsible for transporting CMP-sialic acids between the cytoplasm and the Golgi apparatus for protein sialylation...
March 9, 2024: Cellular and Molecular Gastroenterology and Hepatology
https://read.qxmd.com/read/38451660/body-fat-composition-in-patients-with-inflammatory-bowel-diseases-a-comparative-study-between-skinfolds-and-ultrasonography
#8
JOURNAL ARTICLE
Isadora Sayuri Macedo Tuma, Maria Paula Carlin Cambi, Thyago Proença de Moraes, Daniéla Oliveira Magro, Paulo Gustavo Kotze
BACKGROUND: Inflammatory bowel diseases (IBD) are associated with important changes in nutritional status. OBJECTIVE: The aim of the study was to compare body fat composition between two anthropometric methods: skinfolds and ultrasonography, in patients with IBD. METHODS: Single-center cross-sectional study with IBD patients in remission or active disease. For the agreement analysis between the body fat assessment methods, the Bland Altman method was used...
2024: Arquivos de Gastroenterologia
https://read.qxmd.com/read/38450510/prior-exposure-to-experimental-preeclampsia-increases-atherosclerotic-plaque-inflammation-in-atherogenic-mice
#9
JOURNAL ARTICLE
Lauren A Biwer, Joshua J Man, Nicholas D Camarda, Brigett V Carvajal, S Ananth Karumanchi, Iris Z Jaffe
BACKGROUND: Women with a history of preeclampsia have evidence of premature atherosclerosis and increased risk of myocardial infarction and stroke compared with women who had a normotensive pregnancy. Whether this is due to common risk factors or a direct impact of prior preeclampsia exposure has never been tested in a mouse atherosclerosis model. METHODS: Pregnant LDLR-KO (low-density lipoprotein receptor knockout; n=35) female mice were randomized in midgestation to sFlt1 (soluble fms-like tyrosine kinase 1)-expressing adenovirus or identical control adenovirus...
March 7, 2024: Arteriosclerosis, Thrombosis, and Vascular Biology
https://read.qxmd.com/read/38422498/matrix-metalloproteinase-9-testing-of-golden-rice-cookies-with-piper-crocatum-active-extract-for-preventing-foot-ulcers-in-patients-with-diabetes-protocol-for-a-randomized-controlled-trial
#10
JOURNAL ARTICLE
Andina Setyawati, Ariyanti Saleh, Takdir Tahir, Saldy Yusuf, Syahrul Syahrul, Aminuddin Aminuddin, Muhammad Raihan, Nuurhidayat Jafar, Hasyrul Hamzah, Nur Arfian
BACKGROUND: Diabetic foot ulcers (DFUs) present a formidable challenge to both patients and health care systems. DFUs significantly reduce the quality of life for patients, prolong hospital stays, and are the cause of approximately 70,000 lower limb amputations across the globe annually. Prevention of DFUs primarily involves the optimization of blood sugar levels and the effective management of complications, particularly peripheral neuropathy. Golden Rice has been proven to lower blood sugar levels due to its beta-carotene content, and Piper crocatum (P...
February 29, 2024: JMIR Research Protocols
https://read.qxmd.com/read/38418870/anaerobic-flora-selenomonas-ruminis-sp-nov-and-the-bacteriocinogenic-ligilactobacillus-salivarius-strain-mp3-from-crossbred-lactating-goats
#11
JOURNAL ARTICLE
Saranporn Poothong, Somboon Tanasupawat, Somchai Chanpongsang, Engkarat Kingkaew, Chackrit Nuengjamnong
This study aimed to examine the distribution of anaerobic bacteria in the rumen fluid of Thai crossbred goats and to screen potential probiotic strains capable of producing antimicrobial compounds and inhibiting bacteria that cause milk fat depression. Thirty-four strains of bacteria from the rumen fluid were divided into 13 groups within 12 genera based on 16S rRNA gene sequences. The RF1-5 and RF5-12 were identified as Streptococcus luteliensis and Bacillus licheniformis, respectively, and demonstrated non-ropy exopolysaccharide...
February 28, 2024: Scientific Reports
https://read.qxmd.com/read/38390098/the-landscape-of-super-enhancer-regulates-remote-target-gene-transcription-through-loop-domains-in-adipose-tissue-of-pig
#12
JOURNAL ARTICLE
Lin Yu, Tengda Huang, Siqi Liu, Jingsu Yu, Menglong Hou, Songtao Su, Tianyu Jiang, Xiangling Li, Yixing Li, Turtushikh Damba, Lei Zhou, Yunxiao Liang
BACKGROUND: A super-enhancer (SE) is a huge cluster of multiple enhancers that control the key genes for cell identity and function. The rise of advanced chromatin immunoprecipitation sequencing (ChIP-seq) technology such as Cleavage Under Targets and Tagmentation (CUT&Tag) allows more SEs to be discovered. However, SE studies in Luchuan and Duroc pigs are very rare in animal husbandry. RESULTS: We used the CUT&Tag technique to identify 145 and 378 SEs from the adipose tissues of Luchuan and Duroc pigs, respectively...
February 29, 2024: Heliyon
https://read.qxmd.com/read/38385285/improvement-of-fruit-juice-quality-novel-endo-polygalacturonase-ii-from-aspergillus-tubingensis-fat-43-for-enhanced-liquefaction-clarification-and-antioxidant-potential
#13
JOURNAL ARTICLE
Marija Pavlović, Aleksandra Margetić, Adrijana Leonardi, Igor Križaj, Milan Kojić, Zoran Vujčić, Marinela Šokarda Slavić
This study focuses on the isolation, purification, and characterisation of endo -polygalacturonase II from Aspergillus tubingensis FAT43, particularly emphasising its potential applications in the fruit juice industry. A comprehensive screening test revealed the temporal dynamics of endo -polygalacturonase production during a 96-hour fermentation process. The purification process, involving ammonium sulfate and ethanol precipitation followed by ion-exchange chromatography, resulted in a 3.3-fold purification of PG II with a yield of 16% and a specific activity of 6001...
February 22, 2024: Food & Function
https://read.qxmd.com/read/38378685/fasting-mimicking-diet-causes-hepatic-and-blood-markers-changes-indicating-reduced-biological-age-and-disease-risk
#14
RANDOMIZED CONTROLLED TRIAL
Sebastian Brandhorst, Morgan E Levine, Min Wei, Mahshid Shelehchi, Todd E Morgan, Krishna S Nayak, Tanya Dorff, Kurt Hong, Eileen M Crimmins, Pinchas Cohen, Valter D Longo
In mice, periodic cycles of a fasting mimicking diet (FMD) protect normal cells while killing damaged cells including cancer and autoimmune cells, reduce inflammation, promote multi-system regeneration, and extend longevity. Here, we performed secondary and exploratory analysis of blood samples from a randomized clinical trial (NCT02158897) and show that 3 FMD cycles in adult study participants are associated with reduced insulin resistance and other pre-diabetes markers, lower hepatic fat (as determined by magnetic resonance imaging) and increased lymphoid to myeloid ratio: an indicator of immune system age...
February 20, 2024: Nature Communications
https://read.qxmd.com/read/38342529/development-and-investigation-of-ultrasound-assisted-pulsed-ohmic-heating-for-inactivation-of-foodborne-pathogens-in-milk-with-different-fat-content
#15
JOURNAL ARTICLE
Eun-Rae Cho, Dong-Hyun Kang
The central objective of this research was to develop an ultrasound-assisted pulsed ohmic heating (POH) system for inactivation of food-borne pathogens in phosphate buffered saline (PBS) and milk with 0-3.6% fat and investigate its bactericidal effect. Combining ultrasound with POH did not significantly affect the temperature profile of samples. Both POH alone and ultrasound-assisted POH took 120 s to heat PBS 60℃. Milk with 0, 1, and 3.6% fat was heated to 60℃ by POH alone and ultrasound-assisted POH after 335, 475, and 525 s, respectively...
March 2024: Food Research International
https://read.qxmd.com/read/38339084/supplemented-infant-formula-and-human-breast-milk-show-similar-patterns-in-modulating-infant-microbiota-composition-and-function-in-vitro
#16
JOURNAL ARTICLE
Klaudyna Borewicz, Wolfram Manuel Brück
The gut microbiota of healthy breastfed infants is often dominated by bifidobacteria. In an effort to mimic the microbiota of breastfed infants, modern formulas are fortified with bioactive and bifidogenic ingredients. These ingredients promote the optimal health and development of infants as well as the development of the infant microbiota. Here, we used INFOGEST and an in vitro batch fermentation model to investigate the gut health-promoting effects of a commercial infant formula supplemented with a blend containing docosahexaenoic acid (DHA) (20 mg/100 kcal), polydextrose and galactooligosaccharides (PDX/GOS) (4 g/L, 1:1 ratio), milk fat globule membrane (MFGM) (5 g/L), lactoferrin (0...
February 2, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38338026/-stc2-inhibits-hepatic-lipid-synthesis-and-correlates-with-intramuscular-fatty-acid-composition-body-weight-and-carcass-traits-in-chickens
#17
JOURNAL ARTICLE
Yuzhu Cao, Qihui Jia, Yuxin Xing, Chenglin Ma, Hongbo Guan, Weihua Tian, Xiangtao Kang, Yadong Tian, Xiaojun Liu, Hong Li
Stanniocalcin 2 (STC2) is a secreted glycoprotein involved in multiple biological processes. To systemically study the biological role of STC2 in chickens, phylogenetic tree analysis and conservation analysis were conducted. Association analysis between variations in the STC2 gene and the economic traits of Gushi-Anka F2 was conducted. The tissue expression patterns of STC2 expression in different chicken tissues and liver at different stages were detected. The biological role of STC2 in chicken liver was investigated through overexpression and interfering methods in the LMH cell line...
January 25, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38306779/android-obesity-could-be-associated-with-a-higher-fall-risk-than-gynoid-obesity-following-a-standing-slip-a-simulation-based-biomechanical-analysis
#18
JOURNAL ARTICLE
Jiyun Ahn, Rebecca Ban, Caroline Simpkins, Feng Yang
It is well recognized that overall obesity increases fall risk. However, it remains unknown if the obesity-induced increase in the fall risk depends upon the adipose distribution (or obesity type: android vs. gynoid). This pilot study examined the effects of fat deposition region on fall risk following a standing-slip trial in young adults with simulated android or gynoid adiposity. Appropriate external weights were attached to two groups of healthy young lean adults at either the abdomen or upper thigh region to simulate android or gynoid adiposity, respectively, with a targeted body mass index of 32 kg/m2 ...
January 26, 2024: Journal of Biomechanics
https://read.qxmd.com/read/38305305/osteocalcin-protects-islet-identity-in-ldl-receptor-knockout-mice-on-high-fat-diet
#19
JOURNAL ARTICLE
Christine A Beamish, Yoon K Lee, A Osama Gaber, Priyanka Chanana, Edward A Graviss, Malgorzata Kloc, M Waleed Gaber, Willa A Hsueh, Omaima M Sabek
Metabolic syndrome (MetS) is an increasing global health threat and strong risk factor for type 2 diabetes (T2D). MetS causes both hyperinsulinemia and islet size overexpansion, and pancreatic beta (β)-cell failure impacts insulin and proinsulin secretion, mitochondrial density, and cellular identity loss. The low-density lipoprotein receptor knockout (LDLr-/-) model combined with high fat diet (HFD) has been used to study alterations in multiple organs, but little is known about changes to β-cell identity resulting from MetS...
February 1, 2024: Journal of Endocrinology
https://read.qxmd.com/read/38304118/a-multi-institutional-assessment-of-low-dose-protocols-in-chest-computed-tomography-dose-and-image-quality
#20
JOURNAL ARTICLE
Elena Tonkopi, Mercy Afadzi Tetteh, Catherine Gunn, Haseem Ashraf, Sigrid Lia Rusten, Perkhah Safi, Nora Suu Tinsoe, Kylie Colford, Olivia Ouellet, Salma Naimi, Safora Johansen
BACKGROUND: Low-dose CT (LDCT) chest protocols have widespread clinical applications for many indications; as a result, there is a need for protocol assessment prior to standardization. Dalhousie University and Oslo Metropolitan University have a formally established cooperative relationship. PURPOSE: The purpose is to assess radiation dose and image quality for LDCT chest protocols in seven different hospital locations in Norway and Canada. MATERIAL AND METHODS: Retrospective dosimetry data, volumetric CT dose index (CTDIvol ), and dose length product (DLP) from 240 average-sized patients as well as CT protocol parameters were included in the survey...
January 2024: Acta Radiologica Open
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