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https://www.readbyqxmd.com/read/29667703/diagnosis-and-management-practices-for-gestational-diabetes-mellitus-in-australia-cross-sectional-survey-of-the-multidisciplinary-team
#1
Nina Meloncelli, Adrian Barnett, Fiona Pelly, Susan de Jersey
BACKGROUND: Gestational diabetes mellitus (GDM) is one of the most common pregnancy disorders; however, if well managed, women with GDM experience similar pregnancy outcomes to those without. Currently, there is limited evidence on actual management practices across Australia or how multidisciplinary teams interact to optimise care. AIMS: To examine the current screening, diagnostic, task and role perceptions and management practices, as reported by members of the GDM multidisciplinary team...
April 18, 2018: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29663938/cohousing-male-mice-with-and-without-segmental-bone-defects
#2
Jeffrey D Rytlewski, Paul J Childress, David C Scofield, Faisal Khan, Marta B Alvarez, Aamir T Tucker, Jonathan S Harris, Jessica L Peveler, Debra L Hickman, Tien-Min G Chu, Melissa A Kacena
Spaceflight results in bone loss like that associated with osteoporosis or decreased weight-bearing (for example, high-energy trauma such as explosive injuries and automobile accidents). Thus, the unique spaceflight laboratory on the International Space Station presents the opportunity to test bone healing agents during weightlessness. We are collaborating with NASA and the US Army to study bone healing in spaceflight. Given the unique constraints of spaceflight, study design optimization was required. Male mice were selected primarily because their femur is larger than females', allowing for more reproducible surgical outcomes...
April 2, 2018: Comparative Medicine
https://www.readbyqxmd.com/read/29661944/atrial-fibrillation-burden-moving-beyond-atrial-fibrillation-as-a-binary-entity-a-scientific-statement-from-the-american-heart-association
#3
REVIEW
Lin Y Chen, Mina K Chung, Larry A Allen, Michael Ezekowitz, Karen L Furie, Pamela McCabe, Peter A Noseworthy, Marco V Perez, Mintu P Turakhia
Our understanding of the risk factors and complications of atrial fibrillation (AF) is based mostly on studies that have evaluated AF in a binary fashion (present or absent) and have not investigated AF burden. This scientific statement discusses the published literature and knowledge gaps related to methods of defining and measuring AF burden, the relationship of AF burden to cardiovascular and neurological outcomes, and the effect of lifestyle and risk factor modification on AF burden. Many studies examine outcomes by AF burden classified by AF type (paroxysmal versus nonparoxysmal); however, quantitatively, AF burden can be defined by longest duration, number of AF episodes during a monitoring period, and the proportion of time an individual is in AF during a monitoring period (expressed as a percentage)...
April 16, 2018: Circulation
https://www.readbyqxmd.com/read/29661548/modal-space-three-state-feedback-control-for-electro-hydraulic-servo-plane-redundant-driving-mechanism-with-eccentric-load-decoupling
#4
Jinsong Zhao, Zhipeng Wang, Chuanbi Zhang, Chifu Yang, Wenjie Bai, Zining Zhao
The shaking table based on electro-hydraulic servo parallel mechanism has the advantage of strong carrying capacity. However, the strong coupling caused by the eccentric load not only affects the degree of freedom space control precision, but also brings trouble to the system control. A novel decoupling control strategy is proposed, which is based on modal space to solve the coupling problem for parallel mechanism with eccentric load. The phenomenon of strong dynamic coupling among degree of freedom space is described by experiments, and its influence on control design is discussed...
April 13, 2018: ISA Transactions
https://www.readbyqxmd.com/read/29661150/a-moderate-500-m-treadmill-walk-for-estimating-peak-oxygen-uptake-in-men-with-nyha-class-i-ii-heart-failure-and-reduced-left-ventricular-ejection-fraction
#5
Gianni Mazzoni, Biagio Sassone, Giovanni Pasanisi, Jonathan Myers, Simona Mandini, Stefano Volpato, Francesco Conconi, Giorgio Chiaranda, Giovanni Grazzi
BACKGROUND: Maximal cardiopulmonary exercise testing (CPX) is the gold-standard for cardiorespiratory fitness assessment in chronic heart failure (CHF) patients. However, high costs, required medical supervision, and safety concerns make maximal exercise testing impractical for evaluating mobility-impaired adults. Thus, several submaximal walking protocols have been developed and currently used to estimate peak oxygen consumption (VO2 peak) in CHF patients. However, these tests have to be performed at close to maximum exercise intensity...
April 16, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29660516/molecular-cloning-and-characterization-of-c-1-tetrahydrofolate-c-1-thf-synthase-in-bombyx-mori-silkworm
#6
Meijun Chen, Jingjie Zhai, Yu Liu, Bin Xue, Jiahuan Hu, Xiaoyu Cheng, Jinxin Li, Jingsheng Hu, Bing Li
Folate metabolism pathway is mainly associated with syntheses of nucleic acids and proteins as well as DNA methylation and repair. Cytoplasmic C1 tetrahydrofolate (C1 -THF) synthase is a central enzyme in folate metabolism and plays an important role in C1 -THF conversion. The full-length sequence of silkworm (Bombyx mori) cytoplasmic C1 -THF synthase (BmC1 -THF synthase) gene including an open reading frame (ORF) of 932 amino acid residues was cloned. Phylogenetic analysis indicated that BmC1 -THF synthase shares 84% and 81% identity with C1 -THF synthase of Papilio Xuthus and Danaus plexippus, respectively...
April 13, 2018: Gene
https://www.readbyqxmd.com/read/29650052/weighting-of-orthostatic-intolerance-time-measurements-with-standing-difficulty-score-stratifies-me-cfs-symptom-severity-and-analyte-detection
#7
Alice M Richardson, Don P Lewis, Badia Kita, Helen Ludlow, Nigel P Groome, Mark P Hedger, David M de Kretser, Brett A Lidbury
BACKGROUND: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is clinically defined and characterised by persistent disabling tiredness and exertional malaise, leading to functional impairment. METHODS: This study introduces the weighted standing time (WST) as a proxy for ME/CFS severity, and investigates its behaviour in an Australian cohort. WST was calculated from standing time and subjective standing difficulty data, collected via orthostatic intolerance assessments...
April 12, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29649054/the-effect-of-a-single-textured-insole-in-gait-rehabilitation-of-individuals-with-stroke
#8
Alexander S Aruin, Noel Rao
Rehabilitation interventions designed to restore gait symmetry in individuals with stroke are not always effective. The goal was to evaluate the long-term effect of using a single textured insole in gait rehabilitation. Ten individuals with stroke who showed asymmetrical stance were randomly divided into two groups and participated in physical therapy. Individuals in the experimental group received a 6-week physical therapy while being provided with a textured insole in the shoe on the unaffected side. Individuals in the control group received a 6-week physical therapy only...
April 11, 2018: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
https://www.readbyqxmd.com/read/29642775/-dis-solving-the-weight-problem-in-binge-eating-disorder-systemic-insights-from-three-treatment-contexts-with-weight-stability-weight-loss-and-weight-acceptance
#9
Lene Bomholt Meyer, Mette Waaddegaard, Marianne Engelbrecht Lau, Tine Tjørnhøj-Thomsen
Binge-eating disorder (BED) is a severe eating disorder strongly associated with obesity. Treatments struggle to provide safe and effective ways of addressing weight in a BED context. This study explored a two-phased treatment for BED developed at a major out-patient eating disorder service in Denmark. The study used interviews and participant observations to gain insight into experiences and processes related to weight and body issues in three treatment contexts that addressed weight stability, weight acceptance, and weight loss...
April 1, 2018: Qualitative Health Research
https://www.readbyqxmd.com/read/29628462/-long-term-dietary-nitrite-and-nitrate-deficiency-causes-metabolic-syndrome-endothelial-dysfunction-and-cardiovascular-death-in-mice
#10
Mika Kina-Tanada, Mayuko Sakanashi, Akira Arasaki, Masato Tsutsui
Nitric oxide (NO) is synthesized not only from L-arginine by NO synthases (NOSs), but also from its inert metabolites, nitrite and nitrate. Green leafy vegetables are abundant in nitrate, however whether or not a deficiency in dietary nitrite/nitrate spontaneously causes disease remains to be clarified. In this study, we tested our hypothesis that long-term dietary nitrite/nitrate deficiency induces metabolic syndrome (MetS) in mice. To this end, we prepared a low nitrite/nitrate diet (LND) consisting of an amino acid-based low nitrite/nitrate chow in which the contents of L-arginine, fat, carbohydrates, protein, and energy were identical with a regular chow, and potable ultrapure water...
2018: Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica
https://www.readbyqxmd.com/read/29621633/molecular-characterization-of-kappa-class-glutathione-s-transferase-from-the-disk-abalone-haliotis-discus-discus-and-changes-in-expression-following-immune-and-stress-challenges
#11
W M Gayashani Sandamalika, Thanthrige Thiunuwan Priyathilaka, D S Liyanage, Sukkyoung Lee, Han-Kyu Lim, Jehee Lee
Glutathione S-transferase (GST; EC 2.5.1.18) isoenzymes represent a complex group of proteins that are involved in phase II detoxification in several organisms. In this study, GST kappa (GSTκ) from the disk abalone (Haliotis discus discus; AbGSTκ) was characterized at both the transcriptional and functional levels to determine its potential capacity to perform as a detoxification agent under conditions of different stress. The predicted AbGSTκ protein consists of 227 amino acids, with a predicted molecular weight of 25...
April 2, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29620385/identity-and-the-body-trajectories-of-body-esteem-from-adolescence-to-emerging-adulthood
#12
Sarah C Nelson, Johanna Kling, Maria Wängqvist, Ann Frisén, Moin Syed
Although Erikson (1968) originally conceptualized identity development as a process of becoming at home in one's body, little work has been done linking identity development and research on the body. This study examines how trajectories of the development of body esteem over time are related to young people's sense of identity and psychological functioning in a longitudinal sample from age 10 to 24 (N = 967). Using group-based trajectory modeling, three cubic subgroups were determined for each of the three types of body esteem: appearance, weight, and attribution...
April 5, 2018: Developmental Psychology
https://www.readbyqxmd.com/read/29618513/the-full-length-cytochrome-p450-enzyme-cyp102a1-dimerizes-at-its-reductase-domains-and-has-flexible-heme-domains-for-efficient-catalysis
#13
Haoming Zhang, Adam L Yokom, Shen Cheng, Min Su, Paul F Hollenberg, Daniel R Southworth, Yoichi Osawa
The cytochrome P450 enzyme CYP102A1 from Bacillus megaterium is a highly efficient hydroxylase of fatty acids, and there is a significant interest in using CYP102A1 for biotechnological applications. Here we used size-exclusion chromatography-multiangle light scattering (SEC-MALS) analysis and negative-stain EM to investigate the molecular architecture of CYP102A1. The SEC-MALS analysis yielded a homogeneous peak with an average molecular weight of 235 ± 5 kDa, consistent with homodimeric CYP102A1. The negative-stain EM of dimeric CYP102A1 revealed four distinct lobes, representing the two heme and two reductase domains...
April 4, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29617946/long-term-selection-of-chickens-for-body-weight-alters-muscle-satellite-cell-behaviors
#14
A E Geiger, M R Daughtry, C M Gow, P B Siegel, H Shi, D E Gerrard
Muscle satellite cells (SC) are resident stem-like cells that play an integral role in skeletal muscle growth and repair. Understanding how SC maintain their identities and dynamic properties is critical to animal growth. However, the genetic and environmental factors governing SC behaviors and the underpinning mechanisms remain unknown. To explore whether genetic selection influences SC behaviors, we used 2 lines of chickens selected for over 50 generations with over a 10-fold difference in body weight at 56 d of age-the Virginia high weight selection (HWS) and low weight selection (LWS) lines...
April 3, 2018: Poultry Science
https://www.readbyqxmd.com/read/29617205/a-novel-method-to-extend-a-partial-body-ct-for-the-reconstruction-of-dose-to-organs-beyond-the-scan-range
#15
Gleb A Kuzmin, Matthew M Mille, Jae Won Jung, Choonik Lee, Christopher Pelletier, Gamal Akabani, Choonsik Lee
Epidemiological investigation is an important approach to assessing the risk of late effects after radiotherapy, and organ dosimetry is a crucial part of such analysis. Computed tomography (CT) images, if available, can be a valuable resource for individualizing the dosimetry, because they describe the specific anatomy of the patient. However, CT images acquired for radiation treatment planning purposes cover only a portion of the body near the target volume, whereas for epidemiology, the interest lies in the more distant normal tissues, which may be located outside the scan range...
April 4, 2018: Radiation Research
https://www.readbyqxmd.com/read/29607458/impact-of-high-magnification-sperm-selection-on-neonatal-outcomes-a-retrospective-study
#16
Olivier Gaspard, Pierre Vanderzwalmen, Barbara Wirleitner, Stéphanie Ravet, Frédéric Wenders, Verena Eichel, Alice Mocková, Dietmar Spitzer, Caroline Jouan, Virginie Gridelet, Henri Martens, Laurie Henry, Herbert Zech, Sophie Perrier d'Hauterive, Michelle Nisolle
PURPOSE: The aim of this study was to compare the effect of the deselection of spermatozoa presenting vacuole-like structures using IMSI (intracytoplasmic morphologically selected sperm injection) with ICSI (intracytoplasmic sperm injection) by means of neonatal outcomes. METHODS: In a retrospective two-center analysis, a total of 848 successful IMSI or ICSI cycles ending with a live birth, induced abortion, or intrauterine fetal death (IUFD) were included. RESULTS: The IMSI and ICSI groups included 332 and 655 babies or fetuses, respectively...
April 2, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29604718/the-dynamic-gammawarp-auditory-filterbank
#17
James M Kates, Shashidhar Prabhu
Auditory filterbanks are an integral part of many metrics designed to predict speech intelligibility and speech quality. Considerations in these applications include accurate reproduction of auditory filter shapes, the ability to reproduce the impact of hearing loss as well as normal hearing, and computational efficiency. This paper presents an alternative method for implementing a dynamic compressive gammachirp (dcGC) auditory filterbank [Irino and Patterson (2006). IEEE Trans. Audio Speech Lang. Proc. 14, 2222-2232]...
March 2018: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/29603829/variable-impact-of-csf-flow-suppression-on-quantitative-3-0t-intracranial-vessel-wall-measurements
#18
Petrice M Cogswell, Jeroen C W Siero, Sarah K Lants, Spencer Waddle, L Taylor Davis, Guillaume Gilbert, Jeroen Hendrikse, Manus J Donahue
BACKGROUND: Flow suppression techniques have been developed for intracranial (IC) vessel wall imaging (VWI) and optimized using simulations; however, simulation results may not translate in vivo. PURPOSE: To evaluate experimentally how IC vessel wall and lumen measurements change in identical subjects when evaluated using the most commonly available blood and cerebrospinal fluid (CSF) flow suppression modules and VWI sequences. STUDY TYPE: Prospective...
March 31, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29601864/tmem2-a-missing-link-in-hyaluronan-catabolism-identified
#19
REVIEW
Yu Yamaguchi, Hayato Yamamoto, Yuki Tobisawa, Fumitoshi Irie
Hyaluronan (HA) is a glycosaminoglycan composed of repeating disaccharide units of glucuronic acid and N-acetylglucosamine. HA is an extremely long, unbranched polymer, which often exceeds 106  Da and sometimes reaches 107  Da. A feature that epitomizes HA is its rapid turnover: one-third of the total body HA is turned over daily. The current model of HA catabolism postulates that high-molecular weight HA in the extracellular space is first cleaved into smaller fragments by a hyaluronidase(s) that resides at the cell surface, followed by internalization of fragments and their degradation into monosaccharides in lysosomes...
March 27, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29596426/quantifying-the-impact-of-scholarly-papers-based-on-higher-order-weighted-citations
#20
Xiaomei Bai, Fuli Zhang, Jie Hou, Ivan Lee, Xiangjie Kong, Amr Tolba, Feng Xia
Quantifying the impact of a scholarly paper is of great significance, yet the effect of geographical distance of cited papers has not been explored. In this paper, we examine 30,596 papers published in Physical Review C, and identify the relationship between citations and geographical distances between author affiliations. Subsequently, a relative citation weight is applied to assess the impact of a scholarly paper. A higher-order weighted quantum PageRank algorithm is also developed to address the behavior of multiple step citation flow...
2018: PloS One
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