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https://www.readbyqxmd.com/read/28214973/a-multifunctional-alanine-rich-anti-inflammatory-peptide-bcp61-showed-potent-inhibitory-effects-by-inhibiting-both-nf-%C3%AE%C2%BAb-and-mapk-expression
#1
Yun Hee Choi, Yoon Seok Choi, Young Kyun Kim, Md Saifur Rahman, G C Pradeep, Jin Cheol Yoo, Joo-Won Suh
The purified BCP61 was reported to be a unique low-molecular-weight (MW) anti-microbial peptide because of its non-identical alanine-rich N-terminal sequence. In this study, we investigated the anti-inflammatory effects of BCP61 on induction of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), pro-inflammatory cytokines, nuclear factor-kappa B (NF-κB), and mitogen-activated protein kinases (MAPKs) in lipopolysaccharide (LPS)-stimulated Raw 264.7 cells. The treatment with BCP61, with varying concentrations of 10, 50, and 100 μg/mL, inhibited levels of expression of LPS-induced NF-κB and MAPKs (extracellular signal-related kinases (ERKs), c-Jun NH2-terminal kinase (JNK), and mitogen-activated protein (p38)) as well as production of pro-inflammatory mediators, such as nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6)...
February 18, 2017: Inflammation
https://www.readbyqxmd.com/read/28212078/demographic-analysis-from-biometric-data-achievements-challenges-and-new-frontiers
#2
Yunlian Sun, Man Zhang, Zhenan Sun, Tieniu Tan
Biometrics is the technique of automatically recognizing individuals based on their biological or behavioral characteristics. Various biometric traits have been introduced and widely investigated, including fingerprint, iris, face, voice, palmprint, gait and so forth. Apart from identity, biometric data may convey various other personal information, covering affect, age, gender, race, accent, handedness, height, weight, etc. Among these, analysis of demographics (age, gender, and race) has received tremendous attention owing to its wide realworld applications, with significant efforts devoted and great progress achieved...
February 14, 2017: IEEE Transactions on Pattern Analysis and Machine Intelligence
https://www.readbyqxmd.com/read/28208489/prediction-of-the-moments-in-advection-diffusion-lattice-boltzmann-method-ii-attenuation-of-the-boundary-layers-via-double-%C3%AE-bounce-back-flux-scheme
#3
Irina Ginzburg
Impact of the unphysical tangential advective-diffusion constraint of the bounce-back (BB) reflection on the impermeable solid surface is examined for the first four moments of concentration. Despite the number of recent improvements for the Neumann condition in the lattice Boltzmann method-advection-diffusion equation, the BB rule remains the only known local mass-conserving no-flux condition suitable for staircase porous geometry. We examine the closure relation of the BB rule in straight channel and cylindrical capillary analytically, and show that it excites the Knudsen-type boundary layers in the nonequilibrium solution for full-weight equilibrium stencil...
January 2017: Physical Review. E
https://www.readbyqxmd.com/read/28208319/robustness-and-fragility-in-coupled-oscillator-networks-under-targeted-attacks
#4
Tianyu Yuan, Kazuyuki Aihara, Gouhei Tanaka
The dynamical tolerance of coupled oscillator networks against local failures is studied. As the fraction of failed oscillator nodes gradually increases, the mean oscillation amplitude in the entire network decreases and then suddenly vanishes at a critical fraction as a phase transition. This critical fraction, widely used as a measure of the network robustness, was analytically derived for random failures but not for targeted attacks so far. Here we derive the general formula for the critical fraction, which can be applied to both random failures and targeted attacks...
January 2017: Physical Review. E
https://www.readbyqxmd.com/read/28207866/a-novel-mechanism-of-metal-gel-shift-by-histidine-rich-ni2-binding-hpn-protein-from-helicobacter-pylori-strain-ss1
#5
Rahul Mahadev Shelake, Yuki Ito, Junya Masumoto, Eugene Hayato Morita, Hidenori Hayashi
Sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) is a universally used method for determining approximate molecular weight (MW) in protein research. Migration of protein that does not correlate with formula MW, termed "gel shifting" appears to be common for histidine-rich proteins but not yet studied in detail. We investigated "gel shifting" in Ni2+-binding histidine-rich Hpn protein cloned from Helicobacter pylori strain SS1. Our data demonstrate two important factors determining "gel shifting" of Hpn, polyacrylamide-gel concentration and metal binding...
2017: PloS One
https://www.readbyqxmd.com/read/28203488/efficacy-and-safety-of-clairyg-%C3%A2-a-ready-to-use-intravenous-immunoglobulin-in-adult-patients-with-primary-immune-thrombocytopenia
#6
Borhane Slama, Olivier Fain, Hervé Maisonneuve, Eric Jourdan, Jean-François Viallard, Rabye Ouaja, Ousmane Alfa-Cissé, Bertrand Godeau
PURPOSE: The present study was designed to assess the efficacy and safety of IGNG that is a new liquid, saccharose and maltose-free highly purified ready-to-use 5% intravenous immunoglobulin (IVIg), in primary immune thrombocytopenic patients with severe thrombocytopenia. METHODS: Nineteen adults with a platelet count ≤ 25 × 10(9)/L received a single dose of IGNG (1 g/kg) on Day 1, with a second identical dose on Day 3 if needed. Patients were followed for 30 days...
2017: American Journal of Blood Research
https://www.readbyqxmd.com/read/28202377/characterization-of-a-new-fungal-immunomodulatory-protein-fip-dsq2-from-dichomitus-squalens
#7
Shuying Li, Zhonghao Jiang, Lichao Sun, Xin Liu, Ying Huang, Fengzhong Wang, Fengjiao Xin
FIP-dsq2, a new immunomodulatory protein, was identified in Basidiomycota Dichomitus squalens by gene mining. FIP-dsq2 contained 111 amino acids with a molecular weight of 12.51kDa. FIP-dsq2 had a homology range of 51-65% to the reported FIPs. The predicted 3-dimensional model had more similar identical folding patterns in LZ-8 than for FIP-fve. Evolutionary analysis indicated substantial phylogenetic differences were existed with the other FIPs. Overexpression of a 14.07kDa soluble rFIP-dsq2 was achieved in Rosetta (pGEX-6T-1) and the purified recombinant protein was homodimer verified by gel filtration chromatography analysis...
February 12, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28201853/antigenic-cross-reactivity-between-schistosoma-mansoni-and-peanut-a-role-for-cross-reactive-carbohydrate-determinants-ccds-and-implications-for-the-hygiene-hypothesis
#8
Joseph E Igetei, Marwa El-Faham, Susan Liddell, Michael J Doenhoff
The antigenic reactivity of constituents of Schistosoma mansoni and peanut (Arachis hypogaea) was investigated to determine whether identical antigenic epitopes possessed by both organisms provided a possible explanation for the negative correlation between chronic schistosome infection and atopy to allergens. Aqueous extracts of peanuts were probed in Western immunoblots with rabbit IgG antibodies raised against the egg, cercarial and adult worm stages of S. mansoni. Several molecules in the peanut extract were antigenically reactive with antibodies from the various rabbit anti-schistosome sera...
February 15, 2017: Immunology
https://www.readbyqxmd.com/read/28198113/early-body-composition-but-not-body-mass-is-associated-with-future-accelerated-decline-in-muscle-quality
#9
Elisa Fabbri, Nancy Chiles Shaffer, Marta Gonzalez-Freire, Michelle D Shardell, Marco Zoli, Stephanie A Studenski, Luigi Ferrucci
BACKGROUND: Muscle quality (MQ) or strength-to-mass ratio declines with aging, but the rate of MQ change with aging is highly heterogeneous across individuals. The identification of risk factors for accelerated MQ decline may offer clues to identity the underpinning physiological mechanisms and indicate targets for prevention and treatment. Using data from the Baltimore Longitudinal Study of Aging, we tested whether measures of body mass and body composition are associated with differential rates of changes in MQ with aging...
February 14, 2017: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/28195932/contrast-agent-induced-high-signal-intensity-in-dentate-nucleus-on-unenhanced-t1-weighted-images-comparison-of-gadodiamide-and-gadoxetic-acid
#10
Shintaro Ichikawa, Utaroh Motosugi, Yoshie Omiya, Hiroshi Onishi
OBJECTIVE: The aim of this study was to evaluate whether an association exists between T1-signal increase in the dentate nucleus (DN) on unenhanced magnetic resonance imaging and previous administration of gadoxetic acid and gadodiamide. MATERIALS AND METHODS: This retrospective study was approved by the institutional review board; the requirement for informed patient consent was waived. A total of 132 patients (male-female ratio, 86:46; mean age, 68.8 ± 11.6 years) who underwent imaging between December 2000 and April 2016 were divided into 4 groups: patients with 5 or more administrations of gadoxetic acid ("gadoxetic acid ≥5 administrations" group), only 1 administration of gadoxetic acid ("gadoxetic acid 1 administration" group), no gadolinium-based contrast agent (GBCA) administration or chronic liver disease (CLD; "no GBCA administration and no CLD" group), and 5 or more administrations of gadodiamide ("gadodiamide ≥5 administrations" group)...
February 11, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28195848/influence-of-indocyanine-green-on-hepatic-gd-eob-dtpa-uptake-a-proof-of-concept-study-in-mice
#11
Hiroyuki Akai, Koichiro Yasaka, Masanori Nojima, Yusuke Inoue, Kuni Ohtomo, Shigeru Kiryu
OBJECTIVES: The aim of this study was to explore the influence of indocyanine green (ICG) on hepatic uptake of gadolinium ethoxybenzyldiethylenetriaminepenta-acetic acid (Gd-EOB-DTPA). MATERIALS AND METHODS: Groups of 6 female C57BL6 mice were injected with 5 mg/kg ICG, 20 mg/kg ICG, or phosphate-buffered saline (control group) 10 minutes before the injection of Gd-EOB-DTPA; identical 3-dimensional gradient echo T1-weighted images were subsequently obtained to create time-intensity curves and to measure the peak contrast ratios (CRs) of liver parenchyma...
February 10, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28191961/poly-glycidyl-ether-based-monolayers-on-gold-surfaces-control-of-grafting-density-and-chain-conformation-by-grafting-procedure-surface-anchor-and-molecular-weight
#12
Silke Heinen, Marie Weinhart
For a meaningful correlation of surface coatings with their respective biological response reproducible coating procedures, well-defined surface coatings, and thorough surface characterization with respect to layer thickness and grafting density are indispensable. The same applies to polymeric monolayer coatings which are intended to be used for, e.g., fundamental studies on the volume phase transition of surface end-tethered thermoresponsive polymer chains. Planar gold surfaces are frequently used as model substrates, since they allow a variety of straightforward surface characterization methods...
February 13, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28190890/c-peptide-baseline-and-postprandial-insulin-resistance-after-a-carbohydrate-rich-test-meal-evidence-for-an-increased-insulin-clearance-in-pcos-patients
#13
J Stassek, J Erdmann, F Ohnolz, F D Berg, M Kiechle, V Seifert-Klauss
Introduction Known characteristics of patients with PCOS include infertility, menstrual disorders, hirsutism and also often insulin resistance. These symptoms increase with increasing body weight. In the LIPCOS study (Lifestyle Intervention for Patients with Polycystic Ovary Syndrome [PCOS]) long-term changes of the PCOS in dependence on pregnancy and parenthood were systematically assessed. In the framework of the LIPCOS study, PCOS patients were given a standardised carbohydrate-rich test meal in order to examine glucose homeostasis and insulin secretion...
January 2017: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/28188261/role-of-genetic-variation-in-collateral-circulation-in-the-evolution-of-acute-stroke-a-multimodal-magnetic-resonance-imaging-study
#14
Yu-Chieh Jill Kao, Esteban A Oyarzabal, Hua Zhang, James E Faber, Yen-Yu Ian Shih
BACKGROUND AND PURPOSE: No studies have determined the effect of differences in pial collateral extent (number and diameter), independent of differences in environmental factors and unknown genetic factors, on severity of stroke. We examined ischemic tissue evolution during acute stroke, as measured by magnetic resonance imaging and histology, by comparing 2 congenic mouse strains with otherwise identical genetic backgrounds but with different alleles of the Determinant of collateral extent-1 (Dce1) genetic locus...
February 10, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28187877/timing-of-initiation-of-adjuvant-chemotherapy-for-gastric-cancer-a-case-matched-comparison-study-of-laparoscopic-vs-open-surgery
#15
A Kaito, T Kinoshita, K Shitara, H Shibasaki, T Nishida
BACKGROUND: Laparoscopic gastrectomy (LG) is reported to be associated with faster recovery than open gastrectomy (OG); however, the influence of the surgical approach on initiation timing of adjuvant chemotherapy (AC) remains unclear. METHODS: This was a single-institutional retrospective observational study. Patients with pathological stage II/III gastric cancer undergoing LG with D2 lymphadenectomy (LG group: n = 74) were matched 1:1 with patients selected from 214 similar patients undergoing OG (OG group: n = 74), identically matching gender, age, pathological stage, and type of gastrectomy, and comparing AC initiation timing between the two groups...
January 29, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28169536/interactions-of-organics-within-hydrated-selective-layer-of-reverse-osmosis-desalination-membrane-a-combined-experimental-and-computational-study
#16
Aziz Ghoufi, Emil Dražević, Anthony Szymczyk
In this work we have examined a computational approach in predicting the interactions between uncharged organic solutes and polyamide membranes. We used three model organic molecules with identical molecular weights (100.1 g/mol), 4-aminopiperidine, 3,3-dimethyl-2-butanone (pinacolone) and methylisobutyl ketone for which we obtained experimental data on partitioning, diffusion and separation on a typical seawater reverse osmosis (RO) membrane. The interaction energy between the solutes and the membrane phase (fully aromatic polyamide) was computed from molecular dynamics (MD) simulations and the resulting sequence was found to correlate well with the experimental rejections and sorption data...
February 14, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28166250/effect-of-plant-diversity-on-the-diversity-of-soil-organic-compounds
#17
Lamiae El Moujahid, Xavier Le Roux, Serge Michalet, Florian Bellvert, Alexandra Weigelt, Franck Poly
The effect of plant diversity on aboveground organisms and processes was largely studied but there is still a lack of knowledge regarding the link between plant diversity and soil characteristics. Here, we analyzed the effect of plant identity and diversity on the diversity of extractible soil organic compounds (ESOC) using 87 experimental grassland plots with different levels of plant diversity and based on a pool of over 50 plant species. Two pools of low molecular weight organic compounds, LMW1 and LMW2, were characterized by GC-MS and HPLC-DAD, respectively...
2017: PloS One
https://www.readbyqxmd.com/read/28164062/case-report-of-mimicry-between-synovial-hemangioma-and-synovial-chondromatosis-of-the-shoulder
#18
Justin Colanese, Akin Cil, Nkem Egekeze, Kamani Lankachandra, Suhel Kotwal
INTRODUCTION: Synovial hemangioma is a developmental hamartoma of vascular tissue within the synovium; no cases involving the shoulder girdle have been described in the literature. Synovial chondromatosis is a benign condition in which synovial cells undergo metaplasia into hyaline cartilage and is also thought to infrequently affect the shoulder region. CASE REPORT: A 44-year-old female presented with left shoulder pain of 7-year duration. Magnetic resonance image displayed a 2...
September 2016: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28163122/comparison-of-bold-diffusion-weighted-fmri-and-adc-fmri-for-stimulation-of-the-primary-visual-system-with-a-block-paradigm
#19
R Nicolas, H Gros-Dagnac, F Aubry, P Celsis
The blood oxygen level-dependent (BOLD) effect is extensively used for functional MRI (fMRI) but presents some limitations. Diffusion-weighted fMRI (DfMRI) has been proposed as a method more tightly linked to neuronal activity. This work proposes a protocol of DfMRI acquired for several b-values and diffusion directions that is compared to gradient-echo BOLD (GE-BOLD) and to repeated spin-echo BOLD (SE-BOLD, acquisitions performed with b=0s/mm(2)), which was also used to ensure the reproducibility of the response...
February 2, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28160361/nonmigrating-equivalent-substitutes-for-pvc-dop-formulations-as-shown-by-a-tg-study-of-pvc-with-covalently-bound-peo-ppo-oligomers
#20
Rodrigo Navarro, Tülin Gacal, Melike Ocakoglu, Carolina García, Carlos Elvira, Alberto Gallardo, Helmut Reinecke
Monoamino functionalized ethylenoxide (EO)/propylenoxide oligomers (Jeffamine) are linked chemically to poly(vinyl chloride) (PVC) using trichlorotriazine chemistry in order to prepare nonmigrating internally plasticized materials. The dependence of the plasticizer efficiency on both the number of anchoring points to the chains and the PVC/plasticizer compatibility is investigated using oligomers of different molecular weight and hydrophilic-hydrophobic balance. Hydrophilic oligomers (containing predominantly EO) of molecular weights between 2000 and 5000 g mol(-1) exhibit excellent plasticizer efficiency, nearly identical to di-2-ethylhexylphthalate (DOP) in conventional PVC/DOP mixtures and may therefore be used as nonmigrating equivalents for DOP...
February 3, 2017: Macromolecular Rapid Communications
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