keyword
MENU ▼
Read by QxMD icon Read
search

Gastro oesophageal reflux disease

keyword
https://www.readbyqxmd.com/read/27904862/risk-factors-for-barrett-s-oesophagus
#1
REVIEW
Neel Sharma, Khek Yu Ho
BACKGROUND: Barrett's oesophagus (BO) is a premalignant condition associated with the development of oesophageal adenocarcinoma (OAC). Globally, the incidence of OAC is rising. Furthermore, the prognosis regarding the morbidity and mortality of OAC is bleak, with an estimated 5-year survival of 10-15%. Hence, detection of the premalignant phase is paramount. Endoscopy and biopsy sampling is the mainstay of diagnosis. Patients may present with symptoms of gastro-oesophageal reflux disease (GORD) or be completely asymptomatic...
October 2016: Gastrointestinal Tumors
https://www.readbyqxmd.com/read/27896821/clinical-symptom-tool-that-raises-the-index-of-suspicion-for-eosinophilic-oesophagitis-in-adults-and-drives-earlier-biopsy-for-definitive-diagnosis
#2
U von Arnim, F-W Röhl, S Miehlke, D Jechorek, D Reinhold, T Wex, P Malfertheiner
BACKGROUND: Eosinophilic oesophagitis (EoE) and gastro-oesophageal reflux disease (GERD) present with overlapping symptomatology and it is challenging to distinguish EoE from GERD clinically before endoscopy. AIM: To investigate the prognostic value of a set of clinical symptoms and laboratory values in patients with EoE and GERD. METHODS: In this prospective, single-centre, observational study, we compared clinical and laboratory data from 202 patients with EoE or GERD (10 relevant characteristics)...
November 29, 2016: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27889322/landmark-reading-alterations-in-patients-with-gastro-oesophageal-reflux-symptoms-undergoing-diagnostic-gastroscopy
#3
Mustafa Kaplan, Alpaslan Tanoglu, Yusuf Serdar Sakin, Taner Akyol, Kemal Oncu, Muammer Kara, Yusuf Yazgan
BACKGROUND AND STUDY AIMS: There is still a debate about the exact measurement of the oesophagogastric junction and the diaphragmatic hiatus among clinicians. The aim of this study was to investigate the differences between landmark readings of gastroscopy on intubation and extubation, and to correlate these readings with a gastro-oesophageal reflux questionnaire. PATIENTS AND METHODS: 116 cases who underwent diagnostic gastroscopy between January 2013 and June 2013 were included in this study...
November 23, 2016: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
https://www.readbyqxmd.com/read/27888615/unconjugated-secondary-bile-acids-activate-the-unfolded-protein-response-and-induce-golgi-fragmentation-via-a-src-kinase-dependant-mechanism
#4
Ruchika Sharma, Francis Quilty, John F Gilmer, Aideen Long, Anne-Marie Byrne
Bile acids are components of gastro-duodenal refluxate and regarded as causative agents in oesophageal disease but the precise mechanisms are unknown. Here we demonstrate that a specific subset of physiological bile acids affect the protein secretory pathway by inducing ER stress, activating the Unfolded Protein Response (UPR) and causing disassembly of the Golgi apparatus in oesophageal cells. Deoxycholic acid (DCA), Chemodeoxycholic acid (CDCA) and Lithocholic acid (LCA) activated the PERK arm of the UPR, via phosphorylation of eIF2α and up-regulation of ATF3, CHOP and BiP/GRP78...
November 23, 2016: Oncotarget
https://www.readbyqxmd.com/read/27862298/two-years-experience-of-using-the-bravo-wireless-oesophageal-ph-monitoring-system-at-a-single-uk-tertiary-centre
#5
Nagendra M Rao, David I Campbell, Prithviraj Rao
AIM: The Bravo wireless pH monitoring system enables oesophageal pH to be monitored in children intolerant to nasal catheters and records measurements over 48 hours. This study aimed to document the minimum child weight that enabled successful capsule placement and any associated complications. We also compared the diagnostic sensitivity of 48 hours versus 24 hours. METHODS: We included 203 consecutive patients (122 male) with clinically documented or suspected reflux symptoms...
November 12, 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/27826993/psychometric-evaluation-of-a-daily-gastro-oesophageal-reflux-disease-symptom-measure
#6
Peter Bytzer, Christina Reimer, Gary Smith, Milena D Anatchkova, Ray Hsieh, Joanne Wilkinson, S Jane Thomas, William R Lenderking
OBJECTIVE: The objective of this study was to evaluate the validity of the Heartburn Reflux Dyspepsia Questionnaire (HRDQ), a newly developed measure of gastro-oesophageal reflux disease (GORD) symptoms. Specifically, the HRDQ was developed for patients, who still experience symptoms with proton pump inhibitor (PPI) treatment. MATERIAL AND METHODS: The psychometric properties of HRDQ were evaluated based on data from two clinical trials of patients with GORD with a partial response to PPIs, one from the UK and one from Denmark and Germany...
November 9, 2016: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/27792252/questionnaire-based-survey-in-a-developing-country-showing-non-compliance-with-paediatric-gastro-oesophageal-reflux-practice-guidelines
#7
Hayat Manasfi, Rima Hanna-Wakim, Imad Akel, Nadine Yazbeck
AIM: This 2015 study investigated whether Lebanese paediatricians diagnosed and managed gastroesophageal reflux disease (GERD) in infants and children in accordance with the 2009 guidelines from the North American and European Societies for Paediatric Gastroenterology, Hepatology and Nutrition. METHODS: Paediatricians members of the Lebanese Order of Physicians with updated email addresses were invited to complete a web-based survey between September and November 2015, to assess their knowledge and management of GERD...
October 28, 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/27779277/persistent-gastro-oesophageal-reflux-symptoms-despite-proton-pump-inhibitor-therapy
#8
Daphne Ang, Choon How How, Tiing Leong Ang
About one-third of patients with suspected gastro-oesophageal reflux disease (GERD) do not respond symptomatically to proton pump inhibitors (PPIs). Many of these patients do not suffer from GERD, but may have underlying functional heartburn or atypical chest pain. Other causes of failure to respond to PPIs include inadequate acid suppression, non-acid reflux, oesophageal hypersensitivity, oesophageal dysmotility and psychological comorbidities. Functional oesophageal tests can exclude cardiac and structural causes, as well as help to confi rm or exclude GERD...
October 2016: Singapore Medical Journal
https://www.readbyqxmd.com/read/27759417/oral-manifestations-of-gastrointestinal-diseases-in-children-part-3-ulcerative-colitis-and-gastro-oesophageal-reflux-disease
#9
C Mantegazza, F Angiero, G V Zuccotti
Alterations of the oral cavity are common in children: 22% of children aged less than 4 years and 44% of those aged more than 12 develop dental erosion, 9-95% of children in Europe and in North America develop gingivitis, with adolescents showing a prevalence of more than 60% [Italian Ministry of Health, Guidelines 2013]. Alterations within the oral cavity can be the first sign of systemic diseases and may thus allow for an early diagnosis and treatment. In particular, being the oral cavity a part of the gastrointestinal system, oral alterations can be an expression of a gastrointestinal disease...
September 2016: European Journal of Paediatric Dentistry: Official Journal of European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/27715354/validated-questionnaires-heighten-detection-of-difficult-asthma-comorbidities
#10
Naghmeh Radhakrishna, Tunn Ren Tay, Fiona Hore-Lacy, Robert Stirling, R Hoy, Eli Dabscheck, Mark Hew
Objective Multiple extra-pulmonary comorbidities contribute to difficult asthma, but their diagnosis can be challenging and time consuming. Previous data on comorbidity detection have focused on clinical assessment, which may miss certain conditions. We aimed to locate relevant validated screening questionnaires to identify extra-pulmonary comorbidities that contribute to difficult asthma, and evaluate their performance during a difficult asthma evaluation. Methods MEDLINE was searched to identify key extra-pulmonary comorbidities that contribute to difficult asthma...
October 7, 2016: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/27629992/the-aging-digestive-tract-what-should-we-anesthesiologists-know-about-it
#11
Alex De Leon
At present, elderly individuals represent approximately 18,5% of the European population and account for about 23% of surgical procedures performed. This patient population is at a higher riskì for perioperative complications and adverse postoperative outcome. This narrative review highlights our current knowledge about physiological changes in the aging gut and the implications for anaesthesiologists. The reduced response to stimuli in the pharynx, and reduction of the cough reflex that occurs in many older individuals, probably explains the increased incidence of aspiration pneumonia that occurs in the elderly...
September 15, 2016: Minerva Anestesiologica
https://www.readbyqxmd.com/read/27615716/asymptomatic-clostridium-difficile-colonisation-in-two-australian-tertiary-hospitals-2012-2014-a-prospective-repeated-cross-sectional-study
#12
Luis Furuya-Kanamori, Archie C A Clements, Niki F Foster, Charlotte A Huber, Stacey Hong, Tiffany Harris-Brown, Laith Yakob, David L Paterson, Thomas V Riley
OBJECTIVES: To investigate the prevalence and risk factors for asymptomatic toxigenic (TCD) and non-toxigenic C. difficile (NTCD)-colonisation in a broad cross-section of the general hospital population over a 3-year period. METHODS: Patients without diarrhoea admitted to two Australian tertiary hospitals were randomly selected through six repeated cross-sectional surveys conducted between 2012 and 2014. Stool specimens were cultured under anaerobic conditions and C...
September 8, 2016: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/27604164/dental-complications-of-gastro-oesophageal-reflux-disease-gord-guidance-for-physicians
#13
Rob Lee, Amin Aminian, Paul Brunton
There is a potential for gastro-oesophageal reflux disease (GORD) to be under diagnosed by physicians. A quick, focused examination, requiring no special equipment, of a patients' dentition can assist in making a more accurate diagnosis where GORD is suspected. Guidance is provided for physicians as to what intra-oral signs are suggestive of intrinsic dental erosion, which is a clinical feature of GORD and its associated conditions. Use of this information will it is suggested improve outcomes for patients where GORD is suspected...
September 8, 2016: Internal Medicine Journal
https://www.readbyqxmd.com/read/27599614/idiopathic-pulmonary-fibrosis-effects-and-optimal-management-of-comorbidities
#14
Christopher S King, Steven D Nathan
Despite the development of pharmacological therapies that are effective in slowing the progression of idiopathic pulmonary fibrosis (IPF), it remains a debilitating and lethal condition. In addition to the adverse effects caused by pulmonary fibrosis, most patients with IPF have associated comorbid conditions, which might negatively affect functional status, quality of life, and survival. Comorbid conditions can be pulmonary or extrapulmonary. Pulmonary comorbidities include pulmonary hypertension, emphysema, and lung cancer, while non-pulmonary conditions include venous thromboembolism, coronary artery disease, congestive heart failure, sleep-disordered breathing, gastro-oesophageal reflux disease, and anxiety or depression...
September 2, 2016: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/27593706/effects-of-omeprazole-or-anti-reflux-surgery-on-lower-oesophageal-sphincter-characteristics-and-oesophageal-acid-exposure-over-10-years
#15
Birgitte-Elise G Emken, Lars R Lundell, Lene Wallin, Helge E Myrvold, Cecilia Engström, Madeleine Montgomery, Anders R Malm, Tore Lind, Jan G Hatlebakk
OBJECTIVE: To compare the effect of anti-reflux surgery (ARS) versus proton pump inhibitor therapy on lower oesophageal sphincter (LOS) function and oesophageal acid exposure in patients with chronic gastro-oesophageal reflux disease (GORD) over a decade of follow-up. MATERIAL AND METHODS: In this randomised, prospective, multicentre study we compared LOS pressure profiles, as well as oesophageal exposure to acid, at baseline and at 1 and 10 years after randomisation to either open ARS (n = 137) or long-term treatment with omeprazole (OME) 20-60 mg daily (n = 108)...
September 3, 2016: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/27586588/the-characterization-of-an-intestine-like-genomic-signature-maintained-during-barrett-s-associated-adenocarcinogenesis-reveals-an-nr5a2-mediated-promotion-of-cancer-cell-survival
#16
Shane P Duggan, Fiona M Behan, Murat Kirca, Abdul Zaheer, Sarah A McGarrigle, John V Reynolds, Gisela M F Vaz, Mathias O Senge, Dermot Kelleher
Barrett's oesophagus (BO), an intestinal-type metaplasia (IM), typically arising in conjunction with gastro-oesophageal reflux disease, is a prominent risk factor for the development of oesophageal adenocarcinoma (OAC). The molecular similarities between IM and normal intestinal tissues are ill-defined. Consequently, the contribution of intestine-enriched factors expressed within BO to oncogenesis is unclear. Herein, using transcriptomics we define the intestine-enriched genes expressed in meta-profiles of BO and OAC...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27582035/dietary-carbohydrate-intake-insulin-resistance-and-gastro-oesophageal-reflux-disease-a-pilot-study-in-european-and-african-american-obese-women
#17
S D Pointer, J Rickstrew, J C Slaughter, M F Vaezi, H J Silver
BACKGROUND: Although obesity rates are higher in African-American than European-American women, gastro-oesophageal reflux disease (GERD) and its comorbidities are more prevalent in European-American women. A common denominator for increased adiposity, and consequent insulin resistance, is excess dietary macronutrient intake - which may promote greater prevalence and severity of GERD in women. AIM: To investigate whether GERD is more robustly associated with dietary carbohydrate intake, particularly dietary simple carbohydrate intake, and insulin resistance in European-American women...
November 2016: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27571366/the-evolution-and-outcome-of-surveillance-of-barrett-s-oesophagus-over-four-decades-in-a-uk-district-general-hospital
#18
Christine Royston, Christine Caygill, Andre Charlett, Karna Dev Bardhan
INTRODUCTION: We present the long-term outcome of Barrett's oesophagus (BO) at a District General Hospital set against the increasing numbers of patients with gastro-oesophageal reflux disease (GORD). METHODS: Data were collected prospectively over 37 years. Comparison of GORD without Barrett's (NoBO) versus BO was performed from 1/1/1977 to 31/12/2001 when the NoBO database closed and outcomes of all cases of BO diagnosed until 31/12/2011 and followed up until 31/12/2013 have been reported...
August 26, 2016: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27554638/distal-mean-nocturnal-baseline-impedance-on-ph-impedance-monitoring-predicts-reflux-burden-and-symptomatic-outcome-in-gastro-oesophageal-reflux-disease
#19
A Patel, D Wang, N Sainani, G S Sayuk, C P Gyawali
BACKGROUND: Mean nocturnal baseline impedance (MNBI), a novel pH-impedance metric, may be a surrogate marker of reflux burden. AIM: To assess the predictive value of MNBI on symptomatic outcomes after anti-reflux therapy. METHODS: In this prospective observational cohort study, pH-impedance studies performed over a 5-year period were reviewed. Baseline impedance was extracted from six channels at three stable nocturnal 10-min time periods, and averaged to yield MNBI...
October 2016: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27554458/laparoscopic-vs-open-nissen-s-fundoplication-for-gastro-oesophageal-reflux-disease-in-children-a-meta-analysis
#20
Peng Zhang, Jing Tian, Li Jing, Quan Wang, Jinhui Tian, Li Lun
BACKGROUND AND OBJECTIVE: Available evidence showed inconsistent results between laparoscopic Nissen's fundoplication (LNF) and open Nissen's fundoplication (ONF) for children with gastro-oesophageal reflux disease (GERD), so this study aimed to evaluate the efficacy and safety between LNF and ONF. METHODS: Systematic, comprehensive literature searches were conducted to include randomized controlled trials (RCTs) that compared LNF and ONF for GERD. Two reviewers independently selected studies, abstracted data and assessed the methodological quality and evidence level...
October 2016: International Journal of Surgery
keyword
keyword
32881
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"