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Gastro oesophageal reflux disease

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https://www.readbyqxmd.com/read/28318045/diagnosis-of-gastro-oesophageal-reflux-disease-is-enhanced-by-adding-oesophageal-histology-and-excluding-epigastric-pain
#1
N Vakil, M Vieth, B Wernersson, J Wissmar, J Dent
BACKGROUND: The diagnosis of gastro-oesophageal reflux disease (GERD) in clinical practice is limited by the sensitivity and specificity of symptoms and diagnostic testing. AIM: To determine if adding histology as a criterion and excluding patients with epigastric pain enhances the diagnosis for GERD. METHODS: Patients with frequent upper gastrointestinal symptoms who had not taken a proton pump inhibitor in the previous 2 months and who had evaluable distal oesophageal biopsies were included (Diamond study: NCT00291746)...
March 20, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28295217/randomized-clinical-trial-of-270%C3%A2-posterior-versus-180%C3%A2-anterior-partial-laparoscopic-fundoplication-for-gastro-oesophageal-reflux-disease
#2
D J Roks, J H Koetje, J E Oor, J A Broeders, V B Nieuwenhuijs, E J Hazebroek
BACKGROUND: Partial fundoplications provide similar reflux control with fewer post-fundoplication symptoms compared with Nissen fundoplication for gastro-oesophageal reflux disease (GORD). The best choice of procedure for partial fundoplication remains unclear. The aim of this study was to compare the outcome of two different types of partial fundoplication for GORD. METHODS: A double-blind RCT was conducted between 2012 and 2015 in two hospitals specializing in antireflux surgery...
March 13, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28282684/-gastro-oesophageal-reflux-disease-how-to-manage-if-ppi-are-not-sufficiently-effective-not-tolerated-or-not-wished
#3
Joachim Labenz, Herbert Koop
Die Standardtherapie der GERD mit PPI ist weniger wirksam als gedacht: Mindestens 30 % der Patienten haben persistierende Symptome und Läsionen (Therapielücke). Bei persistierender Symptomatik oder Wunsch einer alternativen Behandlung ist eine stratifizierte Diagnostik erforderlich. Alginate und neue Operationsverfahren erweitern die Therapieoptionen.
March 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28281472/impact-of-concomitant-laparoscopic-sleeve-gastrectomy-and-hiatal-hernia-repair-on-gastro-oesophageal-reflux-disease-in-morbidly-obese-patients
#4
Harshit Garg, Balasubiramaniyan Vigneshwaran, Sandeep Aggarwal, Vineet Ahuja
BACKGROUND: The aim of this study was to analyse the impact of hiatal hernia repair (HHR) on gastro-oesophageal reflux disease (GERD) in morbidly obese patients with hiatus hernia undergoing laparoscopic sleeve gastrectomy (LSG). MATERIALS AND METHODS: It is a retrospective study involving ten morbidly obese patients with large hiatus hernia diagnosed on pre-operative endoscopy who underwent LSG and simultaneous HHR. The patients were assessed for symptoms of GERD using a Severity symptom score (SS) questionnaire and anti-reflux medications...
April 2017: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/28255095/acceptability-of-the-cytosponge-procedure-for-detecting-barrett-s-oesophagus-a-qualitative-study
#5
Madeleine Freeman, Judith Offman, Fiona M Walter, Peter Sasieni, Samuel G Smith
OBJECTIVE: To investigate the acceptability of the Cytosponge, a novel sampling device to detect Barrett's oesophagus (BE), a precursor to oesophageal adenocarcinoma (EAC), among people with risk factors for this condition. DESIGN: A qualitative study using semistructured interviews and focus group discussions. Data were explored by three researchers using thematic analysis. SETTING: Community setting in London, UK. PARTICIPANTS: A recruitment company identified 33 adults (17 men, 16 women) aged 50-69 years with gastro-oesophageal reflux disease (GERD), a risk factor for BE...
March 1, 2017: BMJ Open
https://www.readbyqxmd.com/read/28251844/overview-of-pathophysiological-features-of-gerd
#6
Paolo Usai Satta, Francesco Oppia, Francesco Cabras
Gastro-esophageal reflux disease (GERD) is a very prevalent condition and has a high impact on the quality of life. Nevertheless, pathophysiology is complex and multi-factorial. Several mechanisms have been proposed: decreased salivation, decreased lower esophageal sphincter pressure resting tone, presence of hiatal hernia, increased number of transient lower esophageal sphincter relaxations, increased acid, and pepsin secretion, duodeno-gastro-esophageal reflux of bile acids and trypsin. Other factors contributing to the pathophysiology of GERD include poor esophageal clearance, delayed gastric emptying and impaired mucosal defensive factors...
March 1, 2017: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/28214353/association-of-gastro-oesophageal-reflux-and-chronic-rhinosinusitis-systematic-review-and-meta-analysis
#7
S R Leason, H P Barham, G Oakley, J Rimmer, J M DelGaudio, J M Christensen, R Sacks, R J Harvey
INTRODUCTION: Gastro-oesophageal reflux disease (GORD) has been implicated in the development of chronic rhinosinusitis (CRS). The association of GORD with CRS is systematically assessed from the medical literature. METHODOLOGY: Embase and MEDLINE were searched using a comprehensive strategy limited to English language and Human subjects. Any study with original data on the experimental, diagnostic, treatment or prognostic association of CRS with GORD was included...
March 1, 2017: Rhinology
https://www.readbyqxmd.com/read/28188078/travelling-abroad-with-cystic-fibrosis-assessment-of-risks-and-healthcare-requirements
#8
Rachel Miller, Laura Blanch, Sarah Lenaghan, Alan Anderson, Simon Doe, Stephen J Bourke
There is limited information on the risks and healthcare requirements of patients with cystic fibrosis (CF) undertaking travel abroad. Of 100 patients (mean age 24.7 years, mean FEV1 57.3 %predicted) attending a UK adult CF Centre, 96% had travelled abroad but 14% now limited travel on medical advice. They travelled frequently and widely, often undertaking adventurous activities on holidays, but because of the costs involved, 18% travelled without travel insurance and 23% with insurance which did not cover CF...
January 24, 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28158901/long-term-symptom-control-of-gastro-oesophageal-reflux-disease-12-years-after-laparoscopic-nissen-or-180%C3%A2-anterior-partial-fundoplication-in-a-randomized-clinical-trial
#9
D J Roks, J A Broeders, R J Baigrie
BACKGROUND: Laparoscopic 180° anterior fundoplication has been shown to achieve similar reflux control to Nissen fundoplication, with fewer side-effects, up to 5 years. However, there is a paucity of long-term follow-up data on this technique and antireflux surgery in general. This study reports 12-year outcomes of a double-blind RCT comparing laparoscopic Nissen versus 180° laparoscopic anterior fundoplication for gastro-oesophageal reflux disease (GORD). METHODS: Patients with proven GORD were randomized to laparoscopic Nissen or 180° anterior fundoplication...
February 3, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28151751/adam-eve-and-the-reflux-enigma-age-and-sex-differences-across-the-gastro-oesophageal-reflux-spectrum
#10
Christine Royston, Karna D Bardhan
INTRODUCTION: We present demographic differences across the gastro-oesophageal reflux disease (GORD) spectrum in a UK District General Hospital. PATIENTS AND METHODS: Data were prospectively collected over 37 years. At endoscopy patients were categorized as: erosive oesophagitis (EO), Barrett's oesophagus (BO) or nonerosive reflux disease (NER). Analysis 1: comparison of EO, BO and NER 1977-2001 when the database for GORD without BO closed. Analysis 2: demographic differences in oesophageal adenocarcinoma (OAC) in total BO population diagnosed 1977-2011...
February 1, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28063112/conversion-of-sleeve-gastrectomy-to-roux-en-y-gastric-bypass-is-effective-for-gastro-oesophageal-reflux-disease-but-not-for-further-weight-loss
#11
Chetan D Parmar, Kamal K Mahawar, Maureen Boyle, Norbert Schroeder, Shlok Balupuri, Peter K Small
INTRODUCTION: Inadequate weight loss (IWL)/weight regain (WR) and gastro-esophageal reflux disease (GERD), unresponsive to medical management, are two most common indications for conversion of sleeve gastrectomy (SG) to Roux-en-Y gastric bypass (RYGB). This study reports detailed outcomes of conversion of SG to RYGB for these two indications separately. METHODS: We interrogated our prospectively maintained database to identify patients who underwent a conversion of their SG to RYGB in our unit...
January 6, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28049126/comorbidities-in-interstitial-lung-diseases
#12
REVIEW
George A Margaritopoulos, Katerina M Antoniou, Athol U Wells
Fibrosing lung disorders include a large number of diseases with diverse behaviour. Patients can die because of the progression of their illness, remain stable or even improve after appropriate treatment has been instituted. Comorbidities, such as acute and chronic infection, gastro-oesophageal reflux, pulmonary hypertension, lung cancer, cardiovascular diseases, and obstructive sleep apnoea, can pre-exist or develop at any time during the course of the disease and, if unidentified and untreated, may impair quality of life, impact upon the respiratory status of the patients, and ultimately lead to disease progression and death...
January 2017: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/28036160/bile-acids-a-potential-role-in-the-pathogenesis-of-pharyngeal-malignancy
#13
Z Shellman, A Aldhahrani, B Verdon, M Mather, V Paleri, J Wilson, J Pearson, C Ward, J Powell
OBJECTIVE: Gastro-oesophageal reflux disease is thought to be a risk factor for head and neck malignancies. Bile acids are one of the principle components of gastric refluxate and have previously been implicated in the development of oesophageal and bowel malignancies. There is clear evidence that bile acids reflux into the laryngopharynx. Despite this, the carcinogenic properties of bile acids in this area are yet to be fully identified. We therefore investigated the potential role of bile acids in pharyngeal malignancy, through the highly conserved process of epithelial-mesenchymal transition (EMT)...
December 30, 2016: Clinical Otolaryngology
https://www.readbyqxmd.com/read/27994297/musculoskeletal-health-of-40-65-year-old-males-and-females-in-kosova-and-the-impact-of-n05b-a02b-ppi-h2ra-h02ab-and-lifestyle-factors-on-it
#14
Ermira Krasniqi, Mynyr Koni, Harald Tschan, Blerim Krasniqi, Antigona Kabashi, Arben Boshnjaku
BACKGROUND: This observational, cross-sectional study investigates the impact of medication usage, physical activity (PA) and nutritional status on musculoskeletal health (MSH) in males and females aged 40-65 in the population of a post conflict, developing country. METHODS: Bone Mineral Density (BMD), T-score and Z-score at distal forearm regions (measured by DEXA scan), together with isometric hand grip strength (dynamometer) were evaluated in a total of 162 subjects (53 Males, average age 55...
October 2016: Medical Archives
https://www.readbyqxmd.com/read/27973922/minimal-differences-in-prevalence-and-spectrum-of-organic-disease-at-upper-gastrointestinal-endoscopy-between-selected-secondary-care-patients-with-symptoms-of-gastro-oesophageal-reflux-or-dyspepsia
#15
Andrew J Irvine, Maria Ines Pinto-Sanchez, Premysl Bercik, Paul Moayyedi, Alexander C Ford
OBJECTIVES: Gastro-oesophageal reflux and dyspepsia are felt to be separate upper gastrointestinal (GI) conditions. We aimed to measure the degree of overlap between them, and assess whether endoscopic findings differed. MATERIAL AND METHODS: Demographic, symptom, upper GI endoscopy and histology data were collected from consecutive adults in secondary care. Patients were categorised according to whether they reported gastro-oesophageal reflux alone, dyspepsia alone or both, and patient demographics and endoscopic findings were compared...
April 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/27956447/towards-understanding-and-managing-chronic-cough
#16
REVIEW
Imran Satia, Huda Badri, Bashar Al-Sheklly, Jaclyn Ann Smith, Ashley A Woodcock
Chronic cough is a common and troublesome condition affecting approximately 12% of the general population. It is associated with poor quality of life with psychological, social and physical consequences. Patients typically complain of a dry irritating cough, driven by a strong urge to cough associated with a sensation or irritation located in the throat. Treatment of potential 'causes', ie asthma, gastro-oesophageal reflux disease and rhino-sinusitis, may produce a complete or partial response, but the response of some patients to opiates and alpha-2-delta ligand antagonists (gabapentin and pregabalin) supports the concept that this is primarily a neurological disorder, characterised by hyper-responsiveness of the nerves...
December 2016: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/27904862/risk-factors-for-barrett-s-oesophagus
#17
REVIEW
Neel Sharma, Khek Yu Ho
BACKGROUND: Barrett's oesophagus (BO) is a premalignant condition associated with the development of oesophageal adenocarcinoma (OAC). Globally, the incidence of OAC is rising. Furthermore, the prognosis regarding the morbidity and mortality of OAC is bleak, with an estimated 5-year survival of 10-15%. Hence, detection of the premalignant phase is paramount. Endoscopy and biopsy sampling is the mainstay of diagnosis. Patients may present with symptoms of gastro-oesophageal reflux disease (GORD) or be completely asymptomatic...
October 2016: Gastrointestinal Tumors
https://www.readbyqxmd.com/read/27896821/clinical-symptom-tool-that-raises-the-index-of-suspicion-for-eosinophilic-oesophagitis-in-adults-and-drives-earlier-biopsy-for-definitive-diagnosis
#18
U von Arnim, F-W Röhl, S Miehlke, D Jechorek, D Reinhold, T Wex, P Malfertheiner
BACKGROUND: Eosinophilic oesophagitis (EoE) and gastro-oesophageal reflux disease (GERD) present with overlapping symptomatology and it is challenging to distinguish EoE from GERD clinically before endoscopy. AIM: To investigate the prognostic value of a set of clinical symptoms and laboratory values in patients with EoE and GERD. METHODS: In this prospective, single-centre, observational study, we compared clinical and laboratory data from 202 patients with EoE or GERD (10 relevant characteristics)...
February 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27889322/landmark-reading-alterations-in-patients-with-gastro-oesophageal-reflux-symptoms-undergoing-diagnostic-gastroscopy
#19
Mustafa Kaplan, Alpaslan Tanoglu, Yusuf Serdar Sakin, Taner Akyol, Kemal Oncu, Muammer Kara, Yusuf Yazgan
BACKGROUND AND STUDY AIMS: There is still a debate about the exact measurement of the oesophagogastric junction and the diaphragmatic hiatus among clinicians. The aim of this study was to investigate the differences between landmark readings of gastroscopy on intubation and extubation, and to correlate these readings with a gastro-oesophageal reflux questionnaire. PATIENTS AND METHODS: 116 cases who underwent diagnostic gastroscopy between January 2013 and June 2013 were included in this study...
December 2016: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
https://www.readbyqxmd.com/read/27888615/unconjugated-secondary-bile-acids-activate-the-unfolded-protein-response-and-induce-golgi-fragmentation-via-a-src-kinase-dependant-mechanism
#20
Ruchika Sharma, Francis Quilty, John F Gilmer, Aideen Long, Anne-Marie Byrne
Bile acids are components of gastro-duodenal refluxate and regarded as causative agents in oesophageal disease but the precise mechanisms are unknown. Here we demonstrate that a specific subset of physiological bile acids affect the protein secretory pathway by inducing ER stress, activating the Unfolded Protein Response (UPR) and causing disassembly of the Golgi apparatus in oesophageal cells. Deoxycholic acid (DCA), Chemodeoxycholic acid (CDCA) and Lithocholic acid (LCA) activated the PERK arm of the UPR, via phosphorylation of eIF2α and up-regulation of ATF3, CHOP and BiP/GRP78...
January 3, 2017: Oncotarget
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