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Gastro oesophageal reflux disease

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https://www.readbyqxmd.com/read/29724467/combined-multichannel-intraluminal-impedance-and-ph-monitoring-is-helpful-in-managing-children-with-suspected-gastro-oesophageal-reflux-disease
#1
Paolo Rossi, Sara Isoldi, Saverio Mallardo, Paola Papoff, Danilo Rossetti, Anna Dilillo, Salvatore Oliva
BACKGROUND: Gastro-oesophageal reflux is very common in the paediatric age group. There is no single and reliable test to distinguish between physiologic and pathological gastro-oesophageal reflux, and this lack of clear distinction between disease and normal can have a negative impact on the management of children. AIMS: To evaluate the usefulness of 24-h oesophageal pH-impedance study in infants and children with suspected gastro-oesophageal reflux disease. METHODS: Patients were classified by age groups (A-C) and reflux-related symptoms (typical and atypical)...
April 5, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29704563/building-a-model-for-day-case-hiatal-surgery-lessons-learnt-over-a-10-year-period-in-a-high-volume-unit-a-case-series
#2
Pritesh Mistry, Shafquat Zaman, Iestyn Shapey, Markos Daskalakis, Rajwinder Nijjar, Martin Richardson, Paul Super, Rishi Singhal
BACKGROUND: Laparoscopic anti-reflux surgery has become the standard treatment for symptomatic gastro-oesophageal reflux disease refractory to medical therapy. Successful anti-reflux surgery involves safe, minimally invasive surgery, resulting in symptom resolution with minimal side effects. This study aims to assess the feasibility and safety of day case anti-reflux surgery focussing on peri- and post-operative outcomes as a measure of success. METHODS: Data was collected from the hospital database from 2003 to 2012...
April 25, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29702986/banxia-xiexin-tang-for-gastro-oesophageal-reflux-disease-a-protocol-for-a-systematic-review-of-controlled-trials
#3
Bohyung Kang, Haesol Lee, Youkyung Choi, Chanyong Jeon, Ju Ah Lee
BACKGROUND: Gastrooesophageal reflux disease (GORD) is one of the most common gastrointestinal diseases encountered in clinical practice. The aim of the present study is thus to systematically review the literature, including Asian studies, to assess the efficacy and safety of Banxia Xiexin tang (BXT) for the treatment of GORD. METHODS AND ANALYSIS: Eleven databases will be searched for studies conducted through March 2018. We will include randomized controlled trials (RCTs) of BXT as a treatment for GORD...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29695236/associations-between-comorbidities-their-treatment-and-survival-in-patients-with-interstitial-lung-diseases-a-claims-data-analysis
#4
Larissa Schwarzkopf, Sabine Witt, Julia Waelscher, Markus Polke, Michael Kreuter
BACKGROUND: Interstitial lung diseases (ILDs) are associated with a high burden of disease. However, data on the prognostic impact of comorbidities and comorbidity-related pharmaceutical treatments in patients with various ILDs remain sparse. METHODS: Using longitudinal claims data from a German Statutory Health Insurance Fund, we assessed comorbidity in ILD subtypes and associated drug treatments. Baseline comorbidity was assessed via the Elixhauser Comorbidity Index that was amended by ILD-relevant conditions...
April 25, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29687210/relationship-between-interstitial-lung-disease-and-oesophageal-dilatation-on-chest-high-resolution-computed-tomography-in-patients-with-systemic-sclerosis-a-cross-sectional-study
#5
Fausto Salaffi, Marco Di Carlo, Marina Carotti, Paolo Fraticelli, Armando Gabrielli, Andrea Giovagnoni
OBJECTIVES: Oesophageal dilatation (OD) has been implicated in the pathogenesis of interstitial lung disease (ILD) in systemic sclerosis (SSc). The aims of this study were to explore the association of the OD and SSc-ILD on chest high-resolution computed tomography (HRCT), and to establish a cutoff point for the OD suggestive for the presence of a significant lung involvement. METHODS: The widest oesophageal diameter (WOD) was obtained on axial HRCT images. The parenchymal abnormalities on HRCT were coded and scored according to Warrick method...
April 23, 2018: La Radiologia Medica
https://www.readbyqxmd.com/read/29685165/gastro-oesophageal-reflux-an-important-causative-factor-of-severe-tooth-wear-in-prader-willi-syndrome
#6
Ronnaug Saeves, Finn Strøm, Leiv Sandvik, Hilde Nordgarden
BACKGROUND: Prader-Willi syndrome (PWS) is the most common genetic human obesity syndrome and is characterized by hypotonia, endocrine disturbances, hyperphagia, obesity and mild mental retardation. Oral abnormalities, such as decreased salivary flow rates and extreme tooth wear, have also been described. Studies have shown a significant increase in reflux symptoms in individuals with obstuctive sleep apnoea syndrome and increased BMI, both of which are typical findings in PWS. Gastro-oesophageal reflux disease (GORD) has been identified in some individuals with PWS and is a significant intrinsic factor in dental tooth wear...
April 23, 2018: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/29644765/correlation-between-novel-3d-high-resolution-manometry-esophagogastric-junction-metrics-and-ph-metry-in-reflux-disease-patients
#7
Y Xiao, Z Lin, Y Li, J E Pandolfino, M Chen, P J Kahrilas
BACKGROUND AND AIMS: We recently developed 2 novel 3D high-resolution manometry (HRM) metrics of esophagogastric junction (EGJ) contractility to differentiate the lower esophageal sphincter (LES) and crural diaphragm (CD) elements of EGJ pressure. This study aimed to compare these metrics to the EGJ-contractile integral (EGJ-CI) and to analyze their correlation with esophageal acid exposure time (AET) on pH-metry. METHODS: Thirty-one gastro-oesophageal reflux disease (GERD) patients and 20 control subjects underwent 24-hour pH-metry and HRM using a 3D-HRM catheter...
April 11, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29602890/childhood-obesity-in-mexico-social-determinants-of-health-and-other-risk-factors
#8
David Avelar Rodriguez, Erick Manuel Toro Monjaraz, Karen Rubi Ignorosa Arellano, Jaime Ramirez Mayans
Approximately 50 million children and adolescents in Latin America are affected by the childhood obesity pandemic. We present the case of a 5-year-old Mexican girl with obesity and gastro-oesophageal reflux disease (GORD), in whom prenatal, lifestyle and environmental risk factors were identified. Here, we demonstrate how childhood obesity is rooted since pregnancy and the perinatal stage, and how the social determinants of health like unsafe outdoor conditions, lack of infrastructure to exercise and a suboptimal physical activity curriculum in government schools strongly influence the development and maintenance of childhood obesity and complicate management...
March 30, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29596177/chapter-5-3-3-the-story-of-gastro-oesophageal-reflux-that-became-a-disease
#9
Gigi Veereman, Yvan Vandenplas, Peter Milla
No abstract text is available yet for this article.
April 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29567854/risk-factors-of-asthma-exacerbation-based-on-asthma-severity-a-nationwide-population-based-observational-study-in-south-korea
#10
Hye-Rim Kang, Hyun Jin Song, Jin Hyun Nam, Sung-Hyun Hong, So-Young Yang, SangEun Ju, Sang Won Lee, Tae-Bum Kim, Hye-Lin Kim, Eui-Kyung Lee
OBJECTIVES: Asthma exacerbation, associated with many risks factors, can reflect management failure. However, little is known about how risk factors are associated with exacerbation, according to asthma severity. We aimed to investigate differences in risk factors in patients with different asthma severity and evaluate whether risk factors differed between frequent exacerbators and patients with single exacerbation. DESIGN: Nationwide population-based observational study...
March 22, 2018: BMJ Open
https://www.readbyqxmd.com/read/29555725/predicting-respiratory-hospital-admissions-in-young-people-with-cerebral-palsy
#11
Amanda Marie Blackmore, Natasha Bear, Eve Blair, Katherine Langdon, Lisa Moshovis, Kellie Steer, Andrew C Wilson
OBJECTIVE: To determine the early predictors of respiratory hospital admissions in young people with cerebral palsy (CP). DESIGN: A 3-year prospective cohort study using linked data. PATIENTS: Children and young people with CP, aged 1 to 26 years. MAIN OUTCOME MEASURES: Self-reported and carer-reported respiratory symptoms were linked to respiratory hospital admissions (as defined by the International Statistical Classification of Diseases and Related Health Problems 10th Revision codes) during the following 3 years...
March 19, 2018: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29545430/aripiprazole-reversed-gastroparesis-in-a-child-with-1q21-1-q21-2-microdeletion
#12
Simon S Rabinowitz, Neha Ahuja, Jennifer Gottfried
An 11-year-old Caucasian boy, with a microdeletion in the 1q21.1-q21.2 region, had multiple medical conditions including gastroparesis documented initially at the age of 5. The patient had a history of poor feeding since infancy and had been treated for gastro-oesophageal reflux disease (GERD), constipation and multiple food allergies. As a consequence of the GERD and his concurrent immunoglobulin (IgG) subclass deficiency, the patient had multiple otolaryngologic (ENT) infections and required two sinus surgeries...
March 15, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29528128/validation-of-the-oesophageal-hypervigilance-and-anxiety-scale-for-chronic-oesophageal-disease
#13
T H Taft, J R Triggs, D A Carlson, L Guadagnoli, K N Tomasino, L Keefer, J E Pandolfino
BACKGROUND: Oesophageal hypervigilance and anxiety can drive symptom experience in chronic oesophageal conditions, including gastro-oesophageal reflux disease, achalasia and functional oesophageal disorders. To date, no validated self-report measure exists to evaluate oesophageal hypervigilance and anxiety. AIMS: This study aims to develop a brief and reliable questionnaire assessing these constructs, the oesophageal hypervigilance and anxiety scale (EHAS). METHODS: Questions for the EHAS were drawn from 4 existing validated measures that assessed hypervigilance and anxiety adapted for the oesophagus...
May 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29527318/study-for-every-other-day-administration-of-vonoprazan-in-maintenance-treatment-of-erosive-gerd-study-protocol-for-a-multicentre-randomised-cross-over-study
#14
Mototsugu Kato, Noriko Ito, Mamiko Demura, Kimitoshi Kubo, Katsuhiro Mabe, Naohiko Harada
Introduction: The first drug selected for treatment of gastro-oesophageal reflux disease (GERD) and prevention of the recurrence is a proton pump inhibitor (PPI), but recently, a potassium-competitive acid blocker (P-CAB) was put on the market in Japan. Its onset of effect is faster than PPI, and it takes more than 2 days to recover acid secretion after the withdrawal period. Therefore, unlike PPI, the usefulness of every other day administration or discontinuous administration is expected...
2018: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29514258/aortopexy-for-the-treatment-of-tracheobronchomalacia-in-100-children-a-10-year-single-centre-experience
#15
Friso M Rijnberg, Colin R Butler, Christian Bieli, Sonia Kumar, Reza Nouraei, Joshua Asto, Eimear McKavanagh, Paolo de Coppi, Nagarajan Muthialu, Martin J Elliott, Richard J Hewitt
OBJECTIVES: Our study describes and analyses the results from aortopexy for the treatment of airway malacia in children. METHODS: Demographic data, characteristics and preoperative, operative and outcome details, including the need for reintervention, were collected for children undergoing aortopexy between 2006 and 2016. RESULTS: One hundred patients [median age 8.2 months, interquartile range (IQR) 3.3-26.0 months] underwent aortopexy...
March 5, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29504332/gastro-oesophageal-reflux-diseases-in-chronic-obstructive-pulmonary-disease-patients
#16
Hamid Nisar Khan, Amir Suleman, Raza Ullah, Azmat Abdullah, Shahida Naz
BACKGROUND: There is an association of Gastroesophageal reflux disease (GERD) with chronic obstructive pulmonary disease (COPD). This study was designed to determine the frequency of GERD in COPD patients. METHODS: This descriptive, cross-sectional study was conducted in the Pulmonology Unit Ayub Teaching Hospital Abbottabad. Patients more than 40 years of age of both genders presenting with features of COPD such as cough and breathlessness for more than 6 months and confirmed by spirometry were included in the study...
January 2018: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/29495041/-gastro-oesophageal-reflux-disease-how-to-manage-if-ppi-are-not-sufficiently-effective-not-tolerated-or-not-wished
#17
Joachim Labenz, Herbert Koop
No abstract text is available yet for this article.
March 2018: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/29495027/erosive-tooth-wear-a-review-on-global-prevalence-and-on-its-prevalence-in-risk-groups
#18
N Schlueter, B Luka
Erosion is a common phenomenon in the general population of developed countries. However, due to variations in indices, sample sizes and general study designs, it is difficult to compare the various studies and to estimate actual global prevalence. Therefore, the aim of this present paper is to give a narrative overview on the data available on the global prevalence of erosion. Information on prevalence is not available from each country; in particular, data from Asia, Africa, South America, North America and large parts of South-Eastern Europe are unavailable...
March 9, 2018: British Dental Journal
https://www.readbyqxmd.com/read/29495022/medical-conditions-and-erosive-tooth-wear
#19
R Moazzez, R Austin
There are many reasons why it is vital that dental professionals identify signs and symptoms that suggest that an individual's erosive tooth wear (ETW) may be linked to a broader medical problem than just poor diet. Primarily, spotting an underlying medical cause for ETW increases the likelihood that further deterioration in the individual's oral health will be prevented. However, perhaps more importantly, many of the medical conditions which are commonly related to ETW can have serious and even possibly fatal consequences if left untreated or not diagnosed...
March 9, 2018: British Dental Journal
https://www.readbyqxmd.com/read/29477057/maintenance-proton-pump-inhibition-therapy-and-risk-of-oesophageal-cancer
#20
Nele Brusselaers, Lars Engstrand, Jesper Lagergren
BACKGROUND: The association of long-term use of proton pump inhibitors (PPIs) with oesophageal adenocarcinoma has been poorly defined. Our aim was to assess the risk of oesophageal cancer assessing confounding by indication. METHODS: This population-based cohort study included all 796,492 adults exposed to maintenance therapy with PPIs in Sweden in 2005-2012. Standardised incidence ratios (SIRs) and 95% confidence intervals (CIs) were calculated to assess the risk of oesophageal adenocarcinoma (and squamous cell carcinoma as a comparison) among long-term PPI users relative to the corresponding background population...
April 2018: Cancer Epidemiology
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