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Gastro oesophageal reflux disease

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https://www.readbyqxmd.com/read/29248880/constrictive-bronchiolitis-presenting-with-a-mixed-obstructive-and-restrictive-pattern-associated-with-acid-reflux
#1
Kristen Capel, Richard Dee Shih
A previously healthy 55-year-old woman presented with worsening dyspnoea on exertion. The patient lived at altitude, did not smoke and had no exposure to occupational or environmental toxins. Her physical examination, including pulmonary, was unremarkable. Pulmonary function tests showed forced expiratory volume in 1 s/forced vital capacity ratio 74% predicted, diffusing capacity for carbon monoxide (DLCO) 92% predicted and residual volume 213% predicted. Rheumatological workup was negative. Chest radiograph showed hyperinflation without consolidation, and high-resolution chest CT showed mosaic attenuation with air trapping on expiratory imaging...
December 15, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29195669/tobacco-smoking-alcohol-consumption-and-gastro-oesophageal-reflux-disease
#2
REVIEW
Eivind Ness-Jensen, Jesper Lagergren
Gastro-oesophageal reflux disease (GORD) develops when reflux of gastric content causes troublesome symptoms or complications. The main symptoms are heartburn and acid regurgitation and complications include oesophagitis, strictures, Barrett's oesophagus and oesophageal adenocarcinoma. In addition to hereditary influence, GORD is associated with lifestyle factors, mainly obesity. Tobacco smoking is regarded as an aetiological factor of GORD, while alcohol consumption is considered a triggering factor of reflux episodes and not a causal factor...
October 2017: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/29193245/review-article-gastro-oesophageal-reflux-disease-in-asthma-and-chronic-obstructive-pulmonary-disease
#3
REVIEW
C Broers, J Tack, A Pauwels
BACKGROUND: When gastro-oesophageal reflux is causing symptoms or lesions in the oesophagus, this is referred to as gastro-oesophageal reflux disease (GERD). GERD can manifest itself through typical symptoms (heartburn, regurgitation) or may lead to extra-oesophageal symptoms. Extra-oesophageal manifestations of GERD gained increasing attention over the last decade, especially respiratory disorders, because of the prevalent co-occurrence with GERD. The role of GERD in the pathogenesis of respiratory disorders has become a topic of intense discussion...
November 29, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29177066/non-acid-gastro-oesophageal-reflux-is-associated-with-squamous-cell-carcinoma-of-the-oesophagus
#4
Mpho Kgomo, Taole R Mokoena, James A Ker
Introduction: Squamous cell carcinoma of the oesophagus is a common cancer among South Africans. Due to the absence of effective screening and surveillance programme for early detection and late presentation, squamous cell carcinoma of the oesophagus is usually diagnosed at an advanced stage or when metastasis has already occurred. The 5-year survival is often quoted at 5%-10%, which is poor. Objectives: To determine the association between oesophageal squamous cell carcinoma (OSCC) and non-acid gastro-oesophageal reflux disease...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29165435/there-is-no-correlation-between-signs-of-reflux-laryngitis-and-reflux-oesophagitis-in-patients-with-gastro-oesophageal-reflux-disease-symptoms
#5
K Zelenik, I M Kajzrlikova, P Vitek, O Urban, M Hanousek, P Kominek
The objective of the present study was to determine if there is correlation between signs of reflux laryngitis (RL) and reflux oesophagitis (RE) in patients with gastro-oesophageal reflux disease (GORD) symptoms. Laryngeal photography obtained from patients during oesophagogastroduodenoscopy were examined by two otolaryngologists experienced in the field of extra-oesophageal reflux regarding the presence and severity of RL. The presence of RE was evaluated by gastroenterologist. Smokers, heavy drinkers and patients with bronchial asthma were excluded from the statistical analysis...
October 2017: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/29151046/the-association-between-gastro-oesophageal-reflux-disease-and-subsequent-rheumatoid-arthritis-occurrence-a-nested-case-control-study-from-taiwan
#6
Herng-Ching Lin, Sudha Xirasagar, Cha-Ze Lee, Chung-Chien Huang, Chao-Hung Chen
OBJECTIVE: Gastro-oesophageal reflux disease (GORD) is a common comorbidity among patients with rheumatoid arthritis (RA). While GORD has been attributed to the antirheumatic medications, no studies of human cohorts have investigated a link between GORD and RA. This study investigates whether GORD is associated with a subsequent RA diagnosis over a 5-year follow-up using a population-based dataset. SETTING: Taiwan PARTICIPANTS: We used data from the Taiwan Longitudinal Health Insurance Database...
November 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/29101500/early-clinical-experiences-with-nintedanib-in-three-uk-tertiary-interstitial-lung-disease-centres
#7
Hannah Toellner, G Hughes, W Beswick, M G Crooks, C Donaldson, I Forrest, S P Hart, C Leonard, M Major, A J Simpson, N Chaudhuri
BACKGROUND: Nintedanib has been shown to slow disease progression in patients with idiopathic pulmonary fibrosis (IPF). It was approved by the National Institute for Health and Care Excellence (NICE) in January 2016 for IPF patients with a forced vital capacity (FVC) of 50-80% in the United Kingdom (UK). AIM: To report real world data about our early clinical experience using nintedanib in 187 patients with a multi-disciplinary (MDT) diagnosis of IPF in a manufacturer funded patient in need scheme (three UK centres) prior to NICE approval...
November 3, 2017: Clinical and Translational Medicine
https://www.readbyqxmd.com/read/29074814/exacerbation-risk-and-characterisation-of-the-uk-s-asthma-population-from-infants-to-old-age
#8
Chloe I Bloom, Francis Nissen, Ian J Douglas, Liam Smeeth, Paul Cullinan, Jennifer K Quint
BACKGROUND: Few studies have examined the characteristics of a general asthma population; most have focused on more severe patients or severe exacerbations. METHODS: This population-based cohort study, from April 2007 to September 2015, used linked primary and secondary care electronic healthcare records (Clinical Practice Research Datalink, Hospital Episode Statistics). Characteristics of four age cohorts, 'Under 5s', '5 to 17s', '18 to 54s', '55+', were described...
October 26, 2017: Thorax
https://www.readbyqxmd.com/read/29026592/yield-of-prolonged-wireless-ph-monitoring-in-achalasia-patients-successfully-treated-with-pneumatic-dilation
#9
Aurelio Mauro, Marianna Franchina, Alessandra Elvevi, Delia Pugliese, Andrea Tenca, Dario Conte, Roberto Penagini
BACKGROUND: Gastro-oesophageal reflux disease (GORD) is a long-term complication of achalasia treatments. The aim of our study was to evaluate the yield of prolonged wireless pH monitoring in patients with successfully treated achalasia and its influence on proton pump inhibitor (PPI) use. METHODS: Twenty-five patients with achalasia who underwent prolonged wireless pH monitoring after a successful treatment with pneumatic dilation were enrolled. pH variables were analysed in the first 24 hours of monitoring to determine if tracings were indicative of GORD; the same variables were analysed in the following 24-hour period in order to obtain a worst-day diagnosis of GORD...
October 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28970029/effect-of-diagnosis-surveillance-and-treatment-of-barrett-s-oesophagus-on-health-related-quality-of-life
#10
REVIEW
James Britton, Richard Keld, Neeraj Prasad, Shaheen Hamdy, John McLaughlin, Yeng Ang
Barrett's oesophagus is a chronic precancerous condition that predisposes patients to the development of oesophageal adenocarcinoma, which, once invasive, carries a poor prognosis. This likelihood of a negative outcome has led to the development of robust surveillance and treatment pathways. The true effect of Barrett's oesophagus on life expectancy and the efficacy of long-term surveillance remains under debate. With these uncertainties and no reliable methods of individual risk stratification, patients must be continually monitored and thus carry the burden of this chronic disease...
September 29, 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28963795/documenting-the-prevalence-of-hiatal-hernia-and-oesophageal-abnormalities-in-brachycephalic-dogs-using-fluoroscopy
#11
E J Reeve, D Sutton, E J Friend, C M R Warren-Smith
OBJECTIVES: To report the prevalence of abnormal fluoroscopic findings in brachycephalic dogs that were presented to a referral hospital for obstructive airway syndrome. METHODS: Hospital records between May 2013 and November 2015 identified 36 brachycephalic dogs investigated for obstructive airway disease: 21 French bulldogs, 6 bulldogs, 4 Boston terriers, 2 pugs, 2 boxers and 1 shih-tzu. The presence or absence of hiatal hernia, delayed oesophageal transit, gastro-oesophageal reflux and redundant oesophagus were recorded...
September 30, 2017: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/28928334/a-collective-review-of-biological-versus-synthetic-mesh-reinforced-cruroplasty-during-laparoscopic-nissen-fundoplication
#12
REVIEW
P S S Castelijns, J E H Ponten, M C G van de Poll, S W Nienhuijs, J F Smulders
BACKGROUND: Laparoscopic cruroplasty and fundoplication have become the gold standard in the treatment of hiatal hernia and gastro-oesophageal reflux disease (GERD). The use of a mesh-reinforcement of the cruroplasty has been proven effective; although, there is a lack of evidence considering which type of mesh is superior. The aim of this study was to compare recurrence rates after mesh reinforced cruroplasty using biological versus synthetic meshes. METHODS: We performed a systematic review of all clinical trials published between January 2004 and September 2015 describing the application of a mesh in the hiatal hernia repair during Nissen fundoplication for both GERD and hiatal hernia...
September 20, 2017: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/28882881/respiratory-manifestations-of-gastro-oesophageal-reflux-in-children
#13
REVIEW
Fernando Maria de Benedictis, Andrew Bush
Gastro-oesophageal reflux disease (GORD) is a complex problem in children. Suspected respiratory manifestations of GORD, such as asthma, chronic cough and laryngitis, are commonly encountered in the paediatric practice, but continue to be entities with more questions than answers. The accuracy of diagnostic tests (ie, pH or pH-impedance monitoring, laryngoscopy, endoscopy) for patients with suspected extraoesophageal manifestations of GORD is suboptimal and therefore whether there is a causal relationship between these conditions remains largely undetermined...
September 7, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28867477/research-priority-setting-in-barrett-s-oesophagus-and-gastro-oesophageal-reflux-disease
#14
James Britton, Lisa Gadeke, Laurence Lovat, Shaheen Hamdy, Chris Hawkey, John McLaughlin, Yeng Ang
The incidence of gastro-oesophageal reflux disease and Barrett's oesophagus is increasing. Barrett's oesophagus is the main precursor to oesophageal adenocarcinoma, which has a poor prognosis. In view of the vast potential burden of these diseases on patients and health-care resources, there is a real need to define and focus research efforts. This priority setting exercise aimed to produce a list of the top ten uncertainties in the field that reflect the priorities of patients and health-care providers. We adopted the robust and transparent methodologies previously outlined by the James Lind Alliance...
November 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28853597/safety-and-effectiveness-of-antireflux-surgery-in-obese-patients
#15
REVIEW
A Tandon, R Rao, A Hotouras, Q M Nunes, M Hartley, R Gunasekera, N Howes
Introduction The incidence of gastro-oesophageal reflux disease and obesity has increased significantly in recent years. The number of antireflux procedures being carried out on people with a higher body mass index (BMI) has been rising. Evidence is conflicting for outcomes of antireflux surgery in obese patients in terms of its safety and efficacy. Given the contradictory reports, this meta-analysis was undertaken to establish the outcomes of antireflux surgery (ARS) in obese patients and its associated safety...
September 2017: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/28839903/bspghan-motility-working-group-position-statement-paediatric-multichannel-intraluminal-ph-impedance-monitoring-indications-methods-and-interpretation
#16
REVIEW
Mohamed Mutalib, David Rawat, Keith Lindley, Osvaldo Borrelli, Steve Perring, Marcus K H Auth, Nikhil Thapar
BACKGROUND: Combined pH-impedance monitoring has been suggested as the investigation of choice for diagnosing gastro-oesophageal reflux in children. Although it is superior to oesophageal pH monitoring in detecting all types of reflux episodes (acid, weakly acidic and alkaline) with the ability to evaluate symptom association with reflux events, it is still limited by the lack of true paediatric normal value and the high cost involved (equipment and personnel). OBJECTIVE: To produce a position statement on behalf of the Motility Working Group of the British Society of Paediatric Gastroenterology, Hepatology and Nutrition on the indications and practical application of combined oesophageal pH-impedance monitoring in children...
July 2017: Frontline Gastroenterology
https://www.readbyqxmd.com/read/28811703/barrett-s-oesophagus-current-controversies
#17
REVIEW
Chidi Amadi, Piers Gatenby
Oesophageal adenocarcinoma is rapidly increasing in Western countries. This tumour frequently presents late in its course with metastatic disease and has a very poor prognosis. Barrett's oesophagus is an acquired condition whereby the native squamous mucosa of the lower oesophagus is replaced by columnar epithelium following prolonged gastro-oesophageal reflux and is the recognised precursor lesion for oesophageal adenocarcinoma. There are multiple national and society guidelines regarding screening, surveillance and management of Barrett's oesophagus, however all are limited regarding a clear evidence base for a well-demonstrated benefit and cost-effectiveness of surveillance, and robust risk stratification for patients to best use resources...
July 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28776330/multidimensional-assessment-of-severe-asthma-a-systematic-review-and-meta-analysis
#18
REVIEW
Vanessa L Clark, Peter G Gibson, Grayson Genn, Sarah A Hiles, Ian D Pavord, Vanessa M McDonald
The management of severe asthma is complex. Multidimensional assessment (MDA) of specific traits has been proposed as an effective strategy to manage severe asthma, although it is supported by few prospective studies. We aimed to systematically review the literature published on MDA in severe asthma, to identify the traits included in MDA and to determine the effect of MDA on asthma-related outcomes. We identified 26 studies and classified these based on study type (cohort/cross-sectional studies; experimental/outcome studies; and severe asthma disease registries)...
October 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28761563/the-emerging-role-of-the-eosinophil-and-its-measurement-in-chronic-cough
#19
REVIEW
Mahboobeh H Sadeghi, Alyn H Morice
Although the aetiology of chronic cough in guidelines is clearly stated as asthma and related syndromes, gastro-oesophageal reflux disease (GORD), and upper airways disease, the inflammatory mechanisms underlying these conditions differ. Recent studies on asthma have increasingly focused on its molecular phenotypes instead of clinical characteristics. Here, we proposed the hypothesis that divides cough into two groups; the eosinophilic and neutrophilic. This division will enhance our ability to recognise the type of airway inflammation which, as a consequence will lead us to more targeted and personalized treatment approaches...
2017: Open Respiratory Medicine Journal
https://www.readbyqxmd.com/read/28698318/words-do-matter-a-systematic-review-on-how-different-terminology-for-the-same-condition-influences-management-preferences
#20
Brooke Nickel, Alexandra Barratt, Tessa Copp, Ray Moynihan, Kirsten McCaffery
OBJECTIVES: Changing terminology for low-risk, screen-detected conditions has now been recommended by several expert groups in order to prevent overdiagnosis and reduce the associated harms of overtreatment. However, the effect of terminology on patients' preferences for management is not well understood. This review aims to synthesise existing studies on terminology and its impact on management decision making. DESIGN: Systematic review. METHODS: Studies were included that compared two or more terminologies to describe the same condition and measured the effect on treatment or management preferences and/or choices...
July 10, 2017: BMJ Open
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