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Gastro oesophageal reflux disease

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https://www.readbyqxmd.com/read/28611061/clinical-events-and-echocardiographic-lesion-progression-rate-in-subjects-with-mild-or-moderate-aortic-regurgitation
#1
Sveeta Badiani, Jet van Zalen, Saad Saheecha, Lesley Hart, Ann Topham, Nikhil Patel, Lydia Sturridge, Andrew Marshall, Neil Sulke, Stephen Furniss, Guy Lloyd
A 69 year old male, an ex-smoker, was admitted with ongoing chest pain of 11 hours duration. Past medical history included treated hypertension and gastro-oesophageal reflux disease. He delayed seeking medical attention as he assumed the pain to be due to indigestion and kept taking antacids without much symptomatic relief. Clinical examination on arrival was unremarkable. Admission 12 lead electrocardiogram (ECG) was diagnostic of a recent anterolateral myocardial infarction (MI) (Figure 1a). Bedside trans-thoracic echocardiogram (TTE) confirmed an established anterolateral MI (Video 1, Figure 1b)...
June 13, 2017: Echo Research and Practice
https://www.readbyqxmd.com/read/28602999/cough-and-bronchiectasis
#2
REVIEW
Paul McCallion, Anthony De Soyza
Bronchiectasis is a chronic lung disease with permanent airway dilatation, mucus retention and recurrent lower respiratory tract infections. Bronchiectasis is increasing in prevalence and has a significant morbidity and an excess mortality rate over age matched controls. It is increasingly identified during investigations into chronic cough and is evident high resolution CT scanning. There remain significant knowledge gaps in our understanding of the epidemiology, pathophysiology, prognosis and optimal treatments in bronchiectasis...
June 7, 2017: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28600380/cohort-profile-the-nordic-antireflux-surgery-cohort-nordasco
#3
John Maret-Ouda, Karl Wahlin, Miia Artama, Nele Brusselaers, Martti Färkkilä, Elsebeth Lynge, Fredrik Mattsson, Eero Pukkala, Pål Romundstad, Laufey Tryggvadóttir, My von Euler-Chelpin, Jesper Lagergren
PURPOSE: To describe a newly created all-Nordic cohort of patients with gastro-oesophageal reflux disease (GORD), entitled the Nordic Antireflux Surgery Cohort (NordASCo), which will be used to compare participants having undergone antireflux surgery with those who have not regarding risk of cancers, other diseases and mortality. PARTICIPANTS: Included were individuals with a GORD diagnosis recorded in any of the nationwide patient registries in the Nordic countries (Denmark, Finland, Iceland, Norway and Sweden) in 1964-2014 (with various start and end years in different countries)...
June 8, 2017: BMJ Open
https://www.readbyqxmd.com/read/28581835/development-and-gamma-scintigraphy-evaluation-of-gastro-retentive-calcium-ion-based-oral-formulation-an-innovative-approach-for-the-management-of-gastro-oesophageal-reflux-disease-gerd
#4
Braj Gaurav Sharma, Kushagra Khanna, Neeraj Kumar, Dhruv K Nishad, Mitra Basu, Aseem Bhatnagar
Calcium chloride is an essential calcium channel agonist which plays an important role in the contraction of muscles by triggering calcium channel. First time hypothesized about its role in the treatment of GER (gastro-oesophageal reflux) and vomiting disorder due to its local action. There are two objectives covered in the present study as first, the development & optimization of floating formulation of calcium chloride and another objective was to evaluated optimized formulation through gamma scintigraphy in human subjects...
June 5, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28579344/evaluation-of-gastro-oesophageal-reflux-disease-in-wheezy-infants-using-24-h-oesophageal-combined-impedance-and-ph-monitoring
#5
Ahmed Abdallah, Tarek El-Desoky, Khalid Fathi, Wagdi Fawzi Elkashef, Ahmed Zaki
BACKGROUND AND STUDY AIMS: Gastro-oesophageal reflux disease (GERD) is incriminated as a cause of non-asthmatic infantile wheeze. To date, no diagnostic test is considered standard for GERD-related airway reflux diagnosis. Oesophageal combined multiple channel intraluminal impedance and pH (MII-pH) monitoring is proposed to be a sensitive tool for evaluation of all GERD including infantile wheeze. We aimed to determine the GERD prevalence amongst wheezy infants in the first year of life using combined MII-pH versus pH monitoring alone and evaluate the sensitivity and specificity of objective MII-pH monitoring parameters in GERD-associated infantile wheeze diagnosis compared to those of lipid-laden macrophage index (LLMI)...
June 1, 2017: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
https://www.readbyqxmd.com/read/28516204/a-novel-dynamic-statistical-model-for-predicting-patient-satisfaction-with-fundoplication-based-on-pre-operative-symptom-patterns
#6
B L Woodham, R Meng, R H Roberts
BACKGROUND: Fundoplication provides excellent control of gastro-oesophageal reflux disease (GORD), but there remain a number of unsatisfied patients who have proven difficult to identify pre-operatively. We hypothesised that pre-operative symptom patterns can predict of the risk of post-operative dissatisfaction. METHODS: Pre-operative symptoms and post-operative satisfaction were measured using standardised questionnaires along with routine investigations. These data were used to calculate our novel pre-operative risk of dissatisfaction (PROD) score...
May 17, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28506663/cough-associated-with-gastro-oesophageal-reflux-disease-gord-japanese-experience
#7
REVIEW
Akio Niimi
Differences in the aetiology as well as patient background of chronic cough have been recognised among US, UK, and Japan. One of the marked differences has been the prevalence of gastro-oesophageal reflux disease (GORD), which has been one of the top three causes in Western countries. It was indeed uncommon or rare in Japan, but, with the increasing prevalence of GOR itself, chronic cough associated with GORD seems to have become more common. In this article, cough associated with GORD will be reviewed based on literature and our Japanese experience...
May 12, 2017: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28502417/analysis-of-bronchial-biopsies-in-chronic-cough
#8
Patricia Macedo, Qingling Zhang, Junpei Saito, Zhike Liang, Lorrette Ffolkes, Andrew G Nicholson, Kian Fan Chung
BACKGROUND: Chronic cough is commonly associated with asthma, gastro-oesophageal reflux disease and postnasal drip, but in a significant proportion, no associated cause can be found. We determined whether examination of bronchial biopsies would be useful in determining the cause associated with chronic cough. METHODS: 100 consecutive patients referred to a specialist cough clinic underwent a systematic assessment including a fiberoptic bronchoscopy for bronchial biopsies...
June 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28464343/randomised-clinical-trial-addition-of-alginate-antacid-gaviscon-double-action-to-proton-pump-inhibitor-therapy-in-patients-with-breakthrough-symptoms
#9
C Coyle, G Crawford, J Wilkinson, S J Thomas, P Bytzer
BACKGROUND: Symptomatic breakthrough in proton pump inhibitor (PPI)-treated gastro-oesophageal reflux disease (GERD) patients is a common problem with a range of underlying causes. The nonsystemic, raft-forming action of alginates may help resolve symptoms. AIM: To assess alginate-antacid (Gaviscon Double Action, RB, Slough, UK) as add-on therapy to once-daily PPI for suppression of breakthrough reflux symptoms. METHODS: In two randomised, double-blind studies (exploratory, n=52; confirmatory, n=262), patients taking standard-dose PPI who had breakthrough symptoms, assessed by Heartburn Reflux Dyspepsia Questionnaire (HRDQ), were randomised to add-on Gaviscon or placebo (20 mL after meals and bedtime)...
May 2, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28447027/gastric-function-in-children-with-oesophageal-atresia-and-tracheoesophageal-fistula
#10
REVIEW
Gilles Duvoisin, Usha Krishnan
Oesophageal atresia and tracheoesophageal fistula (OA-TOF) are a multifaceted condition which affects patients throughout their lives. Even though it is one of the most common gastrointestinal malformations, most of the current studies focus on gastro-oesophageal reflux disease, anastomotic strictures, and feeding difficulties. However, there is increasing evidence that a proportion of patients with OA-TOF also have abnormal gastric function. This review aims to provide a comprehensive understanding of studies of gastric function in patients with OA-TOF...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28425352/overdose-in-young-children-treated-with-anti-reflux-medications-poisons-enquiry-evidence-of-excess-10-fold-dosing-errors-with-ranitidine
#11
C Crawford, M Anderson, G Cooper, G Jackson, J Thompson, A Vale, Shl Thomas, M Eddleston, D N Bateman
BACKGROUND: Accidental drug overdose is a common problem in young children. We examined the influence of formulation and dose in enquiries for different gastro-oesophageal reflux disease treatments in children under 5 years to the UK's National Poisons Information Service. METHODS: Overdose characteristics with ranitidine, omeprazole or domperidone were compared with those of metoclopramide and the H-1 antagonist chlorphenamine, for the period 1 July 2007 to 30 June 2015...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/28420670/confirmed-early-myocardial-rupture-in-a-patient-with-pulseless-electrical-activity-pea-following-late-presentation-of-st-elevation-myocardial-infarction
#12
Baskar Sekar, Joe Martins, Sanjiv Petkar
No abstract text is available yet for this article.
June 2017: Echo Research and Practice
https://www.readbyqxmd.com/read/28413064/systemic-sclerosis
#13
REVIEW
Christopher P Denton, Dinesh Khanna
Systemic sclerosis, also called scleroderma, is an immune-mediated rheumatic disease that is characterised by fibrosis of the skin and internal organs and vasculopathy. Although systemic sclerosis is uncommon, it has a high morbidity and mortality. Improved understanding of systemic sclerosis has allowed better management of the disease, including improved classification and more systematic assessment and follow-up. Additionally, treatments for specific complications have emerged and a growing evidence base supports the use of immune suppression for the treatment of skin and lung fibrosis...
April 13, 2017: Lancet
https://www.readbyqxmd.com/read/28398152/multichannel-intra-luminal-impedance-signals-variability-during-gastro-oesophageal-activities
#14
Bahaa Al-Sheikh, V Chandrasekar, Tom Stuebe
Multichannel intra-luminal impedance (MII) technique has been proven to be a successful diagnostic tool in detecting and displaying activities inside the oesophagus. It improves the diagnostic capability of oesophageal disorders since it gives accurate and more in-depth information about the activities inside the oesophagus, especially reflux episodes. A comparison is presented between normal and abnormal adults in terms of variability in MII signals during baselines and reflux episodes. A comparative study of episode duration for normal and abnormal subjects is presented...
May 2017: Journal of Medical Engineering & Technology
https://www.readbyqxmd.com/read/28378957/asthma-and-gastro-oesophageal-reflux-disease-a-multidisciplinary-point-of-view
#15
Paolo Solidoro, Filippo Patrucco, Sharmila Fagoonee, Rinaldo Pellicano
Asthma and gastro-oesophageal reflux (GORD) are widespread and potentially coexisting diseases. Incidence and prevalence of concomitant asthma and GORD are highly variable among studies. This is mainly due to the heterogeneity of study designs. To explain a potential link, it has been proposed some pathophysiological anomaly such as the altered pressure gradient between thorax and abdomen, the parasympathethic reflex, the hightened bronchial reactivity and chemical effects of microaspired gastric juice. An accurate diagnosis of asthma and GORD are pivotal in order to lead effective treatment and to reach a significant positive outcome, in terms of quality of life and respiratory function amelioration...
April 4, 2017: Minerva Medica
https://www.readbyqxmd.com/read/28365622/proton-pump-inhibitor-failure-in-gastro-oesophageal-reflux-disease-a-perspective-aided-by-the-gartner-hype-cycle
#16
Robert C Heading
Some patients with gastro-oesophageal reflux disease (GORD) experience symptoms despite proton pump inhibitor (PPI) treatment. In the early years of their availability, these drugs were thought to be a highly effective treatment for GORD and realisation that symptom relief was often incomplete came as a disappointment. This review considers the evolution of thinking with the aid of the Gartner hype cycle - a graphical depiction of the process of innovation, evolution and adoption of new technologies. Acknowledging that over-simplistic concepts of GORD have been largely responsible for inflated expectations of PPI therapy is an important step forward in establishing how patients with persistent symptoms, despite PPIs, should be assessed and treated...
April 2017: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/28344983/effects-of-bile-acids-on-human-airway-epithelial-cells-implications-for-aerodigestive-diseases
#17
Adil Aldhahrani, Bernard Verdon, Chris Ward, Jeffery Pearson
Gastro-oesophageal reflux and aspiration have been associated with chronic and end-stage lung disease and with allograft injury following lung transplantation. This raises the possibility that bile acids may cause lung injury by damaging airway epithelium. The aim of this study was to investigate the effect of bile acid challenge using the immortalised human bronchial epithelial cell line (BEAS-2B). The immortalised human bronchial epithelial cell line (BEAS-2B) was cultured. A 48-h challenge evaluated the effect of individual primary and secondary bile acids...
January 2017: ERJ Open Research
https://www.readbyqxmd.com/read/28344981/the-effects-of-exogenous-lipid-on-thp-1-cells-an-in-vitro-model-of-airway-aspiration
#18
Yvette A Hayman, Laura R Sadofsky, James D Williamson, Simon P Hart, Alyn H Morice
Chronic inflammatory diseases of the airways are associated with gastro-oesophageal reflux (GOR) and aspiration events. The observation of lipid-laden macrophages (LLMs) within the airway may indicate aspiration secondary to GOR. The proposed mechanism, that lipid droplets from undigested or partially digested food are aspirated leading to accumulation in scavenging macrophages, led us to hypothesise that an activated population of LLMs could interact with other immune cells to induce bronchial inflammation...
January 2017: ERJ Open Research
https://www.readbyqxmd.com/read/28326569/the-dynamics-of-the-oesophageal-squamous-epithelium-normalisation-process-in-patients-with-gastro-oesophageal-reflux-disease-treated-with-long-term-acid-suppression-or-anti-reflux-surgery
#19
RANDOMIZED CONTROLLED TRIAL
L Mastracci, R Fiocca, C Engström, S Attwood, C Ell, J P Galmiche, J G Hatlebakk, G Långström, S Eklund, T Lind, L Lundell
BACKGROUND: Proton pump inhibitors and laparoscopic anti-reflux surgery (LARS) offer long-term symptom control to patients with gastro-oesophageal reflux disease (GERD). AIM: To evaluate the process of 'normalisation' of the squamous epithelium morphology of the distal oesophagus on these therapies. METHODS: In the LOTUS trial, 554 patients with chronic GERD were randomised to receive either esomeprazole (20-40 mg daily) or LARS. After 5 years, 372 patients remained in the study (esomeprazole, 192; LARS, 180)...
May 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28318045/diagnosis-of-gastro-oesophageal-reflux-disease-is-enhanced-by-adding-oesophageal-histology-and-excluding-epigastric-pain
#20
COMPARATIVE STUDY
N Vakil, M Vieth, B Wernersson, J Wissmar, J Dent
BACKGROUND: The diagnosis of gastro-oesophageal reflux disease (GERD) in clinical practice is limited by the sensitivity and specificity of symptoms and diagnostic testing. AIM: To determine if adding histology as a criterion and excluding patients with epigastric pain enhances the diagnosis for GERD. METHODS: Patients with frequent upper gastrointestinal symptoms who had not taken a proton pump inhibitor in the previous 2 months and who had evaluable distal oesophageal biopsies were included (Diamond study: NCT00291746)...
May 2017: Alimentary Pharmacology & Therapeutics
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