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https://www.readbyqxmd.com/read/28446005/cardioprotective-effects-of-wharton-jelly-derived-mesenchymal-stem-cell-transplantation-in-a-rodent-model-of-myocardial-injury
#1
Taghrid Gaafar, Wael Attia, Shereen Mahmoud, Dina Sabry, Osama Abdel Aziz, Dina Rasheed, Hala Hamza
Background: Whartons jelly-derived mesenchymal stem cells are a valuable alternative source that possess multipotent properties, easy to obtain and available in large scale compared to BMMSCs. We investigated the possibility of cardiac function improvement post isoproterenol induced cardiac injury in a rat model following human WJMSCs transplantation. Materials and Methods: MSCs were extracted and cultured from cord WJ, characterized by morphology, Immunophenotyping and differentiation to osteoblast and adipocytes...
April 30, 2017: International Journal of Stem Cells
https://www.readbyqxmd.com/read/28445743/egfr-targeted-micelles-containing-near-infrared-dye-for-enhanced-photothermal-therapy-in-colorectal-cancer
#2
Ying-Hsia Shih, Tsai-Yueh Luo, Ping-Fang Chiang, Cheng-Jung Yao, Wuu-Jyh Lin, Cheng-Liang Peng, Ming-Jium Shieh
The purpose of this research was to investigate the effectiveness of epidermal growth factor receptor (EGFR) targeted micelles loaded with IR-780 (Cetuximab/IR-780/micelles) for generating tumor targeting, multimodal images, and photothermal therapy (PTT). We initially studied the cellular uptake of these micelles using the HCT-116 and SW-620 cell lines. HCT-116 (high expression of EGFR) and SW-620 (low expression of EGFR) cell lines were used to examine biodistribution and antitumor effects of Cetuximab/IR-780/micelles...
April 23, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28445714/the-toll-like-receptor-2-agonist-pam3csk4-is-neuroprotective-after-spinal-cord-injury
#3
Nicole S Stivers, Nicolas Pelisch, Ben C Orem, Joshua Williams, Jacqueline M Nally, David P Stirling
Microglia/macrophage activation and recruitment following spinal cord injury (SCI) is associated with both detrimental and reparative functions. Stimulation of the innate immune receptor Toll-like receptor-2 (TLR2) has shown to be beneficial following SCI, and it increases axonal regeneration following optic nerve crush. However, the mechanism(s) remain unclear. As microglia express high levels of TLR2, we hypothesized that modulating the microglial response to injury using a specific TLR2 agonist, Pam3CSK4, would prevent secondary-mediated white matter degeneration following SCI...
April 23, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28445649/high-serum-stability-of-collagen-hybridizing-peptides-and-their-fluorophore-conjugates
#4
Lucas L Bennink, Daniel J Smith, Catherine A Foss, Martin G Pomper, Yang Li, S Michael Yu
Collagen hybridizing peptides (CHPs) have a great potential for use in targeted drug delivery, diagnostics, and regenerative medicine due to their ability to specifically bind to denatured collagens associated with many pathologic conditions. Since peptides generally suffer from poor enzymatic stability resulting in rapid degradation and elimination in vivo, CHP's serum stability is a critical parameter that may dictate its pharmacokinetic behavior. Here, we report the serum stability of a series of monomeric CHP derivatives and establish how peptide length, amino acid composition, terminal modification, and linker chemistry influence their availability in serum...
April 26, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28445644/broadband-fluorescence-enhancement-with-self-assembled-silver-nanoparticle-optical-antennas
#5
Carolin Vietz, Izabela Kaminska, Maria Sanz Paz, Philip Tinnefeld, Guillermo P Acuna
Plasmonic structures are known to affect the fluorescence properties of dyes placed in close proximity. This effect has been exploited in combination with single-molecule techniques for several applications in the field of biosensing. Among these plasmonic structures, top-down zero mode waveguides stand out due to their broadband capabilities. In contrast, optical antennas based on gold nanostructures exhibit fluorescence enhancement on a narrow fraction of the visible spectrum typically restricted to the red to near-infrared region...
April 26, 2017: ACS Nano
https://www.readbyqxmd.com/read/28445426/the-effects-of-magnesium-supplementation-on-subjective-anxiety-and-stress-a-systematic-review
#6
REVIEW
Neil Bernard Boyle, Clare Lawton, Louise Dye
BACKGROUND: Anxiety related conditions are the most common affective disorders present in the general population with a lifetime prevalence of over 15%. Magnesium (Mg) status is associated with subjective anxiety, leading to the proposition that Mg supplementation may attenuate anxiety symptoms. This systematic review examines the available evidence for the efficacy of Mg supplementation in the alleviation of subjective measures of anxiety and stress. METHODS: A systematic search of interventions with Mg alone or in combination (up to 5 additional ingredients) was performed in May 2016...
April 26, 2017: Nutrients
https://www.readbyqxmd.com/read/28445136/selective-eradication-of-cancer-cells-by-delivery-of-adenovirus-based-toxins
#7
Shiran Shapira, Assaf Shapira, Diana Kazanov, Gil Hevroni, Sarah Kraus, Nadir Arber
BACKGROUND AND OBJECTIVE: KRAS mutation is an early event in colorectal cancer carcinogenesis. We previously reported that a recombinant adenovirus, carrying a pro-apoptotic gene (PUMA) under the regulation of Ets/AP1 (RAS-responsive elements) suppressed the growth of cancer cells harboring hyperactive KRAS. We propose to exploit the hyperactive RAS pathway, rather than to inhibit it as was previously tried and failed repeatedly. We aim to improve efficacy by substituting PUMA with a more potent toxin, the bacterial MazF-MazE toxin-antitoxin system, under a very tight regulation...
April 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28444822/triplex-dna-nanostructures-from-basic-properties-to-applications
#8
Yuwei Hu, Alessandro Cecconello, Andrea Idili, Francesco Ricci, Itamar Willner
Triplex nucleic acids attract recent interest as part of the rich "tool-box" of structures used to develop DNA-based nanostructures and materials. This review addresses the use of DNA triplexes to assemble sensing platforms and molecular switches. Furthermore, the pH-induced, switchable assembly and dissociation of triplex DNA-bridged nanostructures are presented. Specifically, the aggregation/deaggregation of nanoparticles and the reversible oligomerization of "origami" tiles or DNA circles are described. Also, the use of triplex-DNA structures as functional units to assemble pH-responsive systems and materials are presented...
April 26, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28444717/effect-of-donor-strength-and-bulk-on-thieno-3-4-b-pyrazine-based-panchromatic-dyes-in-dscs
#9
Nalaka P Liyanage, Hammad Cheema, Alexandra R Baumann, Alexa R Zylstra, Jared Heath Delcamp
NIR absorbing organic dyes are critically needed in dye-sensitized solar cells (DSCs). Thieno[3,4-b]pyrazine (TPz) based dyes can access the near-infrared (NIR) spectral region and show power conversion efficiencies (PCEs) of up to 8.1% with sunlight being converted at wavelengths up to 800 nm for 17.6 mA/cm2 of photocurrent in a co-sensitized DSC device. Precisely controlling dye excited-state energies is critical for good performances in NIR DSCs. Strategies to control TPz dye energetics with stronger donor groups and TPz substituent choice are evaluated in this manuscript...
April 25, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28444593/decolourization-and-biodegradation-of-navy-blue-her-reactive-blue-171-dye-from-marasmius-sp-bbkav79
#10
Adiveppa B Vantamuri, Basappa B Kaliwal
White rot fungus Marasmius sp. BBKAV79 (GenBank accession number-KP455496, KP455497) exhibited decolourization and degradation of Navy blue HER dye (concentration 50 mg l(-l)) within 24 h under shaking condition. In the present study, various investigated parameters like initial dye concentration, pH, temperature, carbon and nitrogen sources were optimized to develop a faster decolourization process by Marasmius sp. BBKAV79. High-performance liquid chromatography, Fourier transform infrared spectroscopy and gas chromatography and mass spectroscopy analysis of the extracted product confirmed the biodegradation of Navy blue HER...
May 2017: 3 Biotech
https://www.readbyqxmd.com/read/28443892/near-infrared-fluorescent-dyes-with-large-stokes-shifts-light-generation-in-bodipys-undergoing-excited-state-intramolecular-proton-transfer
#11
Qiang Fei, Xianfeng Gu, Yajing Liu, Ben Shi, Hengyan Liu, Ge Xu, Chunbao Li, Ping Shi, Chunchang Zhao
Novel BODIPYs undergoing excited state intramolecular proton transfer are reported. The molecules afford NIR emission with a large Stokes shift and possess a free hydroxyl unit that is easy to functionalize, allowing the dyes to be exploited as a valuable scaffold in probe design.
April 26, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28443887/metal-ion-induced-supramolecular-pka-tuning-and-fluorescence-regeneration-of-a-p-sulfonatocalixarene-encapsulated-neutral-red-dye
#12
M N Shinde, R Khurana, N Barooah, A C Bhasikuttan, J Mohanty
The host-guest interactions and the consequent modulation in the prototropic equilibrium of a phenazine dye, neutral red, with p-sulfonatocalix[4]arene (SCX4) and p-sulfonatocalix[6]arene (SCX6) macrocyclic hosts have been investigated. Both the neutral (NR) and cationic (NRH(+)) forms of dyes formed inclusion complexes with SCX6, with a larger binding constant for the latter (K = 8.6 × 10(5) M(-1)versus 4.8 × 10(3) M(-1)) due to the cation receptor behavior of the calixarenes. The distinct differences in the binding constant of NR and NRH(+) provided a finite tuning of pKa between 6...
April 26, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28443601/self-assembly-of-defect-rich-graphene-oxide-nanosheets-with-na-sub-2-sub-ti-sub-3-sub-o-sub-7-sub-nanowires-and-their-superiorly-absorptive-capacity-towards-to-toxic-dyes
#13
Yibai Sun, Wanlin Fu, Yunqian Dai, Yiyang Huang, Jie Zhou, Chengqian Huang, Chongya Yang, Meiyou Huang, Rongwei Ma, Baoping Lin
Graphene sheets, a flexible two-dimensional material with excellent absorptive capacity, have great potential as absorbing materials. However, it has always been suffering from irreversible aggregation and thus lose the abundant active sites and large surface area. In this paper, large-scale graphene oxide (GO) sheets were cut and reduced into tiny reduced graphene oxide (RGO) sheets by a cell-break sonicator, for producing numerous defects which is the center of chemisorption. Furthermore, sodium titanate nanowires functioned as a framework help to disperse tiny RGO sheets uniformly...
April 26, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28443520/recent-advances-on-3-hydroxyflavone-derivatives-structures-and-properties
#14
Burcu Butun, Gulacti Topcu, Turan Ozturk
Flavonoids are naturally occurring phenolic compounds named as 2-phenyl-1-benzopyran-4-one and classified into several subclasses according to their basic chemical structures such as flavones, flavonols, flavanones, flavanonols, and flavanols. Among them, flavonols (3-hydroxyflavone), containing a 3-hydroxyl group in association with its 4-keto group and double bond between 2- and 3- carbon atoms, have the best electron conjugated skeleton in flavonoid family, providing several resonance structures and chelating ability, through which various pharmacological activities such as antiviral, antitumor, anti-inflammatory, anticholinesterase, cytotoxicity, and particularly high antioxidant activity are demonstrated...
April 24, 2017: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/28443303/cutaneous-ulceration-and-breast-implant-compromise-after-pulse-dye-laser-for-radiation-induced-telangiectasias
#15
Anthony M Rossi, Kishwer S Nehal, Babak Mehrara, Erica Lee
No abstract text is available yet for this article.
May 2017: JAAD Case Reports
https://www.readbyqxmd.com/read/28442922/inhibition-of-pcsk9-protects-against-radiation-induced-damage-of-prostate-cancer-cells
#16
Si-Shun Gan, Jian-Qing Ye, Lei Wang, Fa-Jun Qu, Chuan-Min Chu, Yi-Jun Tian, Wei Yang, Xin-Gang Cui
BACKGROUND: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a protein expressed primarily in the liver, formerly known to maintain plasma lipid homeostasis by regulating low-density lipoprotein receptor levels, and its exact role in the radioresistance of prostate cancer (PCa) remains unclear. We aim to investigate the function of PCSK9 in the radioresistance of PCa cells. METHODS: PCSK9 small interfering RNA (siRNA) was introduced into the PCa cells by transient transfection...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28442771/double-stranded-dna-induces-a-prothrombotic-phenotype-in-the-vascular-endothelium
#17
Erik Gaitzsch, Thomas Czermak, Andrea Ribeiro, Yvonn Heun, Monica Bohmer, Monika Merkle, Hanna Mannell, Christian Schulz, Markus Wörnle, Joachim Pircher
Double-stranded DNA (dsDNA) constitutes a potent activator of innate immunity, given its ability to bind intracellular pattern recognition receptors during viral infections or sterile tissue damage. While effects of dsDNA in immune cells have been extensively studied, dsDNA signalling and its pathophysiological implications in non-immune cells, such as the vascular endothelium, remain poorly understood. The aim of this study was to characterize prothrombotic effects of dsDNA in vascular endothelial cells. Transfection of cultured human endothelial cells with the synthetic dsDNA poly(dA:dT) induced upregulation of the prothrombotic molecules tissue factor and PAI-1, resulting in accelerated blood clotting in vitro, which was partly dependent on RIG-I signalling...
April 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28442440/impact-of-dose-and-surface-features-on-plasmatic-and-liver-concentrations-of-biodegradable-polymeric-nanocapsules
#18
Líliam Teixeira Oliveira, Mônica Auxiliadora de Paula, Bruno Mendes Roatt, Giani Martins Garcia, Luan Silvestro Bianchini Silva, Alexandre Barbosa Reis, Carina Silva de Paula, José Mário Carneiro Vilela, Margareth Spangler Andrade, Gwenaelle Pound-Lana, Vanessa Carla Furtado Mosqueira
The effect of polymeric nanocapsule dose on plasmatic and liver concentrations 20min after intravenous administration in mice was evaluated. Nanocapsules were prepared with different polymers, namely, poly(D,L-lactide) (PLA), polyethylene glycol-block-poly(D,L-lactide) (PLA-PEG), and PLA with chitosan (PLA-Cs) and compared with a nanoemulsion. These formulations were labelled with a phthalocyanine dye for fluorescent detection. The nanostructures had narrow size distributions upon separation by asymmetric flow field flow fractionation with static and dynamic light scattering detection, with average hydrodynamic diameters in the 130-300nm range, negative zeta potentials, except PLA-Cs nanocapsules, which had a positive zeta potential...
April 22, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28442407/light-magnetic-hyperthermia-triggered-drug-released-from-multi-functional-thermo-sensitive-magnetoliposomes-for-precise-cancer-synergetic-theranostics
#19
Yuxin Guo, Yang Zhang, Jinyuan Ma, Qi Li, Yang Li, Xinyi Zhou, Dan Zhao, Hua Song, Qing Chen, Xuan Zhu
Precise delivery of antineoplastic drugs to specific tumor region has drawn much attention in recent years. Herein, a light/magnetic hyperthermia triggered drug delivery with multiple functionality is designed based on methotrexate (MTX) modified thermo-sensitive magnetoliposomes (MTX-MagTSLs). In this system, MTX and oleic acid modified magnetic nanoparticles (MNPs) can be applied in biological and magnetic targeting. Meanwhile, lipophilic fluorescent dye Cy5.5 and MNPs are encapsulated into the bilayer of liposomes, which can not only achieve dual-imaging effect to verify the MTX-MagTSLs accumulation in tumor region, but also provide an appropriate laser irradiation region to release Doxorubicin (Dox) under alternating magnetic field (AMF)...
April 22, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28441952/management-of-suspected-primary-toxoplasma-gondii-infection-in-pregnant-women-in-norway-twenty-years-of-experience-of-amniocentesis-in-a-low-prevalence-population
#20
Gry Findal, Anne Helbig, Guttorm Haugen, Pål A Jenum, Babill Stray-Pedersen
BACKGROUND: Primary infection with Toxoplasma gondii during pregnancy may pose a threat to the fetus. Women infected prior to conception are unlikely to transmit the parasite to the fetus. If maternal serology indicates a possible primary infection, amniocentesis for toxoplasma PCR analysis is performed and antiparasitic treatment given. However, discriminating between primary and latent infection is challenging and unnecessary amniocenteses may occur. Procedure-related fetal loss after amniocentesis is of concern...
April 26, 2017: BMC Pregnancy and Childbirth
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