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https://www.readbyqxmd.com/read/29324069/evidence-based-guidelines-for-fatigue-risk-management-in-emergency-medical-services
#1
P Daniel Patterson, J Stephen Higgins, Hans P A Van Dongen, Daniel J Buysse, Ronald W Thackery, Douglas F Kupas, David S Becker, Bradley E Dean, George H Lindbeck, Francis X Guyette, Josef H Penner, John M Violanti, Eddy S Lang, Christian Martin-Gill
BACKGROUND: Administrators of Emergency Medical Services (EMS) operations lack guidance on how to mitigate workplace fatigue, which affects greater than half of all EMS personnel. The primary objective of the Fatigue in EMS Project was to create an evidence-based guideline for fatigue risk management tailored to EMS operations. METHODS: Systematic searches were conducted from 1980 to September 2016 and guided by seven research questions framed in the Population, Intervention, Comparison, Outcome (PICO) framework...
January 11, 2018: Prehospital Emergency Care
https://www.readbyqxmd.com/read/29322610/safety-and-efficacy-of-once-weekly-semaglutide-versus-additional-oral-antidiabetic-drugs-in-japanese-subjects-with-inadequately-controlled-t2d-a-randomised-trial
#2
Kohei Kaku, Yuichiro Yamada, Hirotaka Watada, Atsuko Abiko, Tomoyuki Nishida, Jeppe Zacho, Arihiro Kiyosue
AIMS: Semaglutide is a glucagon-like peptide 1 analogue in development for type 2 diabetes (T2D). Safety and efficacy of once-weekly subcutaneous semaglutide as monotherapy or combined with an oral antidiabetic drug (OAD) vs an additional OAD was evaluated in Japanese subjects with T2D inadequately controlled on diet/exercise or OAD monotherapy. METHODS: In this phase 3, open-label trial, adults with T2D were randomised 2:2:1 to semaglutide 0.5 mg or 1.0 mg, or one additional OAD (dipeptidyl peptidase-4 inhibitor, biguanide, sulphonylurea, glinide, α-glucosidase inhibitor or thiazolidinedione) with different modes of action...
January 11, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29316130/efficacy-and-safety-of-fast-acting-insulin-aspart-in-comparison-with-insulin-aspart-in-type-1-diabetes-onset%C3%A2-1-a-52-week-randomized-treat-to-target-phase%C3%A2-3-trial
#3
Chantal Mathieu, Bruce W Bode, Edward Franek, Athena Philis-Tsimikas, Ludger Rose, Tina Graungaard, Anne Birk Østerskov, David Russell-Jones
AIMS: Compare safety and efficacy of fast-acting insulin aspart (faster aspart) with conventional insulin aspart (IAsp) in adults with type 1 diabetes (T1D). MATERIALS AND METHODS: onset 1 was a randomized, multicentre, treat-to-target, phase 3, 52-week (initial 26 weeks + additional 26 weeks) trial conducted at 165 sites across nine countries. Adults with T1D were randomly allocated to double-blind mealtime faster aspart or IAsp, each with once- or twice-daily insulin detemir...
January 8, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29315176/outcome-measures-for-baro-challenge-induced-eustachian-tube-dysfunction-a-systematic-review
#4
Bhavesh V Tailor, Matthew E Smith, Peter J A Hutchinson, James R Tysome
OBJECTIVES: Baro-challenge-induced Eustachian tube dysfunction (baro-induced ETD) is characterized by failure of the Eustachian tube (ET) to open adequately to permit middle-ear pressure regulation during ambient pressure changes. There are no well-characterized tests for identifying the condition, which makes both patient diagnosis and research into treatment efficacy challenging. This systematic review evaluates ET function tests as potential outcome measures for baro-induced ETD. DATA SOURCES: MEDLINE and CENTRAL were searched (database inception to March 2017) and reference lists reviewed for all relevant English Language articles...
February 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29313451/microcystin-lr-degradation-utilizing-a-novel-effective-indigenous-bacterial-community-yfmcd1-from-lake-taihu
#5
Fei Yang, Isaac Yaw Massey, Jian Guo, Shu Yang, Yuepu Pu, Weiming Zeng, Hongzhuan Tan
Microcystins (MC) produced by species of cyanobacteria including Microcystis, Anabaena, and Aphanizomenon are a group of monocyclic hepatotoxins posing serious threat to public health. Microcystin-LR (MC-LR) is the most toxic and frequently encountered microcystin variant in the environment, and thus removal of this toxin using bacteria was shown to be a reliable, efficient, and cost-effective method that avoids utilization of chemicals that may produce potentially harmful by-products. The aim of this study was to determine whether a novel indigenous bacterial community designated YFMCD1 was effective in destroying MC...
January 9, 2018: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/29313205/distinguishing-sulfotyrosine-containing-peptides-from-their-phosphotyrosine-counterparts-using-mass-spectrometry
#6
Guangming Chen, Yixiang Zhang, Jonathan C Trinidad, Charles Dann
Sulfotyrosine and phosphotyrosine are two post-translational modifications present in higher eukaryotes. A simple and direct mass spectrometry method to distinguish between these modifications is crucial to advance our understanding of the sulfoproteome. While sulfation and phosphorylation are nominally isobaric, the accurate mass of the sulfuryl moiety is 9.6 mDa less than the phosphoryl moiety. Based on this difference, we have used an Orbitrap Fusion Lumos mass spectrometer to characterize, resolve, and distinguish between sulfotyrosine and phosphotyrosine modifications using a set of model peptides...
January 8, 2018: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/29305645/free-visual-exploration-of-natural-movies-in-schizophrenia
#7
Johanna Elisa Silberg, Ioannis Agtzidis, Mikhail Startsev, Teresa Fasshauer, Karen Silling, Andreas Sprenger, Michael Dorr, Rebekka Lencer
BACKGROUND: Eye tracking dysfunction (ETD) observed with standard pursuit stimuli represents a well-established biomarker for schizophrenia. How ETD may manifest during free visual exploration of real-life movies is unclear. METHODS: Eye movements were recorded (EyeLink®1000) while 26 schizophrenia patients and 25 healthy age-matched controls freely explored nine uncut movies and nine pictures of real-life situations for 20 s each. Subsequently, participants were shown still shots of these scenes to decide whether they had explored them as movies or pictures...
January 5, 2018: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/29299834/ethcd-discrimination-of-isomeric-leucine-isoleucine-residues-in-sequencing-of-the-intact-skin-frog-peptides-with-intramolecular-disulfide-bond
#8
Tatiana Yu Samgina, Sergey V Kovalev, Miriam D Tolpina, Polonca Trebse, Gregor Torkar, Albert T Lebedev
Our scientific interests involve de novo sequencing of non-tryptic natural amphibian skin peptides including those with intramolecular S-S bond by means of exclusively mass spectrometry. Reliable discrimination of the isomeric leucine/isoleucine residues during peptide sequencing by means of mass spectrometry represents a bottleneck in the workflow for complete automation of the primary structure elucidation of these compounds. MS3 is capable of solving the problem. Earlier we demonstrated the advanced efficiency of ETD-HCD method to discriminate Leu/Ile in individual peptides by consecutive application of ETD to the polyprotonated peptides followed by HCD applied to the manually selected primary z-ions with the targeted isomeric residues at their N-termini and registration of the characteristic w-ions...
January 3, 2018: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/29285624/balloon-dilatation-of-the-eustachian-tube-in-adult-patients-with-chronic-dilatory-tube-dysfunction-a-retrospective-cohort-study
#9
M C Satmis, M van der Torn
OBJECTIVES: The aim of this study is to assess the subjective and objective short-term results and safety of transnasal balloon dilatation of the Eustachian tube (BET) in adult patients with chronic dilatory Eustachian tube dysfunction (ETD). DESIGN: Retrospective cohort study. Data collection was performed preoperatively, 1 and 3 months after BET. SETTING: Tertiary referral hospital. PARTICIPANTS: A cohort of 42 consecutive patients (66 ears)...
December 29, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29249155/exploring-ecd-on-a-benchtop-q-exactive-orbitrap-mass-spectrometer
#10
Kyle L Fort, Christian N Cramer, Valery G Voinov, Yury V Vasilev, Nathan I Lopez, Joseph S Beckman, Albert J R Heck
As the application of mass spectrometry intensifies in scope and diversity, the need for advanced instrumentation addressing a wide variety of analytical needs also increases. To this end, many modern, top-end mass spectrometers are designed or modified to include a wider range of fragmentation technologies, e.g. ECD, ETD, EThcD, and UVPD. Still, the majority of instrument platforms are limited to more conventional methods, such as CID and HCD. While these latter methods have performed well, the less conventional fragmentation methods have been shown to lead to increased information in many applications including middle-down proteomics, top-down proteomics, glycoproteomics and disulfide bond mapping...
December 18, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/29246950/efficacy-and-safety-of-once-weekly-semaglutide-versus-exenatide-er-in-subjects-with-type-2-diabetes-sustain-3-a-56-week-open-label-randomized-clinical-trial
#11
Andrew J Ahmann, Matthew Capehorn, Guillaume Charpentier, Francesco Dotta, Elena Henkel, Ildiko Lingvay, Anders G Holst, Miriam P Annett, Vanita R Aroda
OBJECTIVE: To compare the efficacy and safety of once-weekly semaglutide 1.0 mg s.c. with exenatide extended release (ER) 2.0 mg s.c. in subjects with type 2 diabetes. RESEARCH DESIGN AND METHODS: In this phase 3a, open-label, parallel-group, randomized controlled trial, 813 subjects with type 2 diabetes taking oral antidiabetic drugs were randomized (1:1) to semaglutide 1.0 mg or exenatide ER 2.0 mg for 56 weeks. The primary end point was change from baseline in HbA1c at week 56...
December 15, 2017: Diabetes Care
https://www.readbyqxmd.com/read/29233911/n-and-o-glycosylation-analysis-of-human-c1-inhibitor-reveals-extensive-mucin-type-o-glycosylation
#12
Kathrin Stavenhagen, H Mehmet Kayili, Stephanie Holst, Carolien Koeleman, Ruchira Engel, Diana Wouters, Sacha Zeerleder, Bekir Salih, Manfred Wuhrer
Human C1-inhibitor (C1-Inh) is a serine protease inhibitor and the major regulator of the contact activation pathway as well as the classical and lectin complement pathways. It is known to be a highly glycosylated plasma glycoprotein. However, both the structural features and biological role of C1-Inh glycosylation are largely unknown. Here, we performed for the first time an in-depth site-specific N- and O-glycosylation analysis of C1-Inh combining various mass spectrometric approaches, including C18-porous graphitized carbon (PGC)-LC-ESI-QTOF-MS/MS applying stepping-energy collision-induced dissociation (CID) and electron-transfer dissociation (ETD)...
December 12, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/29227048/the-prevalence-of-eustachian-tube-dysfunction-symptoms-in-patients-with-chronic-rhinosinusitis
#13
Navarat Tangbumrungtham, Vishal S Patel, Andrew Thamboo, Zara M Patel, Jayakar V Nayak, Yifei Ma, Garret Choby, Peter H Hwang
BACKGROUND: While Eustachian tube dysfunction (ETD) is a known comorbidity of chronic rhinosinusitis (CRS), the prevalence of ETD symptoms in the CRS population is poorly understood. We sought to determine the cross-sectional prevalence of ETD in patients with CRS using the validated Eustachian Tube Dysfunction Questionnaire (ETDQ-7) and to correlate ETDQ-7 scores with 22-item Sino-Nasal Outcome Test (SNOT-22) scores, endoscopy scores, and computed tomography (CT) scores. METHODS: A total of 101 patients with confirmed CRS completed the ETDQ-7 and SNOT-22 at their initial visit to our rhinology clinic...
December 11, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29224762/outcomes-of-tympanoplasty-in-children-with-down-syndrome
#14
Saied Ghadersohi, Jonathan B Ida, Bharat Bhushan, Kathleen R Billings
INTRODUCTION: The prevalence of chronic otitis media with effusion (COME), and Eustachian tube dysfunction (ETD) is high in Down syndrome (DS) patients. This often necessitates multiple tympanostomy tube (TT) placements resulting in a higher rate of persistent tympanic membrane (TM) perforation requiring tympanoplasty for repair. OBJECTIVES: To assess risk factors for persistent perforation and outcomes of tympanoplasty in DS patients. METHODS: Retrospective case series of 91 ears in 69 DS patients with TM perforations, who were either observed or underwent tympanoplasty...
December 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29188338/effects-of-hypoglycaemia-on-working-memory-and-regional-cerebral-blood-flow-in-type-1-diabetes-a-randomised-crossover-trial
#15
Michael Gejl, Albert Gjedde, Birgitte Brock, Arne Møller, Eelco van Duinkerken, Hanne L Haahr, Charlotte T Hansen, Pei-Ling Chu, Kirstine L Stender-Petersen, Jørgen Rungby
AIMS/HYPOTHESIS: The aim of this randomised, crossover trial was to compare cognitive functioning and associated brain activation patterns during hypoglycaemia (plasma glucose [PG] just below 3.1 mmol/l) and euglycaemia in individuals with type 1 diabetes mellitus. METHODS: In this patient-blinded, crossover study, 26 participants with type 1 diabetes mellitus attended two randomised experimental visits: one hypoglycaemic clamp (PG 2.8 ± 0.2 mmol/l, approximate duration 55 min) and one euglycaemic clamp (PG 5...
November 29, 2017: Diabetologia
https://www.readbyqxmd.com/read/29183199/exploration-of-doubtful-cases-of-leucine-and-isoleucine-discrimination-in-mass-spectrometric-peptide-sequencing-by-electron-transfer-and-higher-energy-collision-dissociation-based-method
#16
Sergey V Kovalyov, Sergey S Zhokhov, Ludmila V Onoprienko, Boris V Vaskovsky, Albert T Lebedev
Electron-transfer dissociation (ETD) and electron-transfer and higher-energy collision dissociation (EThcD) spectra of short tryptic peptides with leucine/isoleucine residues in neighboring positions demonstrate intensive w-ions. On the contrary, u-ions possess very low intensities (if present at all). Therefore radical site migration is negligible in the applied conditions while ETD (EThcD) spectra allow for the reliable discrimination of the isomeric residues in the sequencing process. The presence of a fragment ion 43...
December 2017: European Journal of Mass Spectrometry
https://www.readbyqxmd.com/read/29172454/the-role-of-electron-transfer-dissociation-in-modern-proteomics
#17
Nicholas M Riley, Joshua J Coon
In the nearly fifteen years since electron transfer dissociation (ETD) was introduced,1 bioanalytical mass spectrometry (MS) and MS-driven proteomics have continued to develop as the premier tools for characterizing proteome composition, structure, and function.2 The new era of proteomics has focused on throughput, sampling depth, and reproducibility - often relying on traditional collision-based dissociation because of its speed and ease of implementation.3-5 That said, the development of alternative dissociation methods remains an active field in proteome research, offering complementary analyses to collisional activation and valuable insights for analytes that can be intractable with traditional methods...
November 27, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29162911/ultrasonographic-measurement-of-the-optic-nerve-sheath-diameter-and-its-association-with-eyeball-transverse-diameter-in-585-healthy-volunteers
#18
Dong Hwan Kim, Jin-Sun Jun, Ryul Kim
The optic nerve sheath diameter (ONSD) is considered as an indirect marker for intracranial pressure (ICP). However, the optimal cut-off value for an abnormal ONSD indicating elevated ICP and its associated factors have been unclear. Thus, we investigated normative values for the ONSD using ultrasonography and investigate the potential factors affecting it. We prospectively recruited healthy volunteers between September 2016 and March 2017. A total of 585 individuals were included, in which the mean ONSD was 4...
November 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29150896/stereospecific-control-of-peptide-gas-phase-ion-chemistry-with-cis-and-trans-cyclo-ornithine-residues
#19
Aleš Marek, Huong T H Nguyen, Břetislav Brož, František Tureček
We report non-chiral amino acid residues cis- and trans-1,4-diaminocyclohexane-1-carboxylic acid (cyclo-ornithine, cO) that exhibit unprecedented stereospecific control of backbone dissociations of singly charged peptide cations and hydrogen-rich cation radicals produced by electron-transfer dissociation (ETD). Upon collision-induced dissociation (CID) in the slow heating regime, peptide cations containing trans-cO residues undergo facile backbone cleavages of amide bonds C-terminal to trans-cO. In contrast, peptides with cis-cO residues undergo dissociations at several amide bonds along the peptide ion backbone...
November 18, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/29144607/eustachian-tube-dysfunction-symptoms-in-patients-treated-in-a-tertiary-rhinology-clinic
#20
Michael J Marino, Lina Chooi Ling, William C Yao, Amber Luong, Martin J Citardi
BACKGROUND: Ear symptoms are common among patients presenting to a rhinology clinic. Validated inventories are available for patient quality-of-life in sinonasal disease and Eustachian tube dysfunction (ETD). This study sought to determine the extent of ETD symptoms, using validated metrics, in a large population of patients presenting to a tertiary rhinology clinic. METHODS: Seven-item Eustachian Tube Dysfunction Questionnaires (ETDQ-7) and 22-item Sino-Nasal Outcome Tests (SNOT-22) were prospectively collected from 492 patients treated in a tertiary rhinology clinic...
November 16, 2017: International Forum of Allergy & Rhinology
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