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https://www.readbyqxmd.com/read/29150896/stereospecific-control-of-peptide-gas-phase-ion-chemistry-with-cis-and-trans-cyclo-ornithine-residues
#1
Aleš Marek, Huong T H Nguyen, Břetislav Brož, František Tureček
We report non-chiral amino acid residues cis- and trans-1,4-diaminocyclohexane-1-carboxylic acid (cyclo-ornithine, cO) that exhibit unprecedented stereospecific control of backbone dissociations of singly charged peptide cations and hydrogen-rich cation radicals produced by electron-transfer dissociation (ETD). Upon collision-induced dissociation (CID) in the slow heating regime, peptide cations containing trans-cO residues undergo facile backbone cleavages of amide bonds C-terminal to trans-cO. In contrast, peptides with cis-cO residues undergo dissociations at several amide bonds along the peptide ion backbone...
November 18, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/29144607/eustachian-tube-dysfunction-symptoms-in-patients-treated-in-a-tertiary-rhinology-clinic
#2
Michael J Marino, Lina Chooi Ling, William C Yao, Amber Luong, Martin J Citardi
BACKGROUND: Ear symptoms are common among patients presenting to a rhinology clinic. Validated inventories are available for patient quality-of-life in sinonasal disease and Eustachian tube dysfunction (ETD). This study sought to determine the extent of ETD symptoms, using validated metrics, in a large population of patients presenting to a tertiary rhinology clinic. METHODS: Seven-item Eustachian Tube Dysfunction Questionnaires (ETDQ-7) and 22-item Sino-Nasal Outcome Tests (SNOT-22) were prospectively collected from 492 patients treated in a tertiary rhinology clinic...
November 16, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29125736/pdeep-predicting-ms-ms-spectra-of-peptides-with-deep-learning
#3
Xie-Xuan Zhou, Wen-Feng Zeng, Hao Chi, Chunjie Luo, Chao Liu, Jianfeng Zhan, Si-Min He, Zhifei Zhang
In tandem mass spectrometry (MS/MS)-based proteomics, search engines rely on comparison between an experimental MS/MS spectrum and the theoretical spectra of the candidate peptides. Hence accurate prediction of the theoretical spectra of peptides appears to be particularly important. Here we present pDeep, a deep neural network- based model for the spectrum prediction of peptides. Using the bidirectional long short- term memory (BiLSTM), pDeep can predict HCD, ETD and EThcD MS/MS spectra of peptides with > 0...
November 10, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29119999/ion-mobility-resolved-collision-induced-dissociation-and-electron-transfer-dissociation-of-n-glycopeptides-gathering-orthogonal-connectivity-information-from-a-single-mass-selected-precursor-ion-population
#4
Venkata Kolli, Katherine N Schumacher, Eric D Dodds
Glycopeptide-level mass spectrometry (MS) and tandem mass spectrometry (MS/MS) analyses are commonly performed to establish site-specific protein glycosylation profiles that are of central importance to gaining structure-function insights on glycoproteins. Confoundingly, the complete characterization of glycopeptide connectivity usually requires the acquisition of multiple MS/MS fragmentation spectra. Complementary ion fragmentation techniques such as collision-induced dissociation (CID) and electron transfer dissociation (ETD) are often applied in concert to address this need...
November 9, 2017: Analyst
https://www.readbyqxmd.com/read/29105695/-grade-evidence-to-decision-etd-frameworks-a-systematic-and-transparent-approach-to-making-well-informed-healthcare-choices-1-introduction
#5
Gian Paolo Morgano, Laura Amato, Elena Parmelli, Lorenzo Moja, Marina Davoli, Holger Schünemann
Following the development of a unifying and transparent approach to grading the certainty of evidence and strength or recommendations, the GRADE (Grading of Recommendations Assessment, Development and Evaluation) Working Group has refined its process of moving from Evidence to Decisions. The purpose of its new Evidence to Decision (EtD) frameworks is to help people use evidence in a structured and transparent way to inform decisions in the context of clinical recommendations, coverage decisions, and health system or public health recommendations and decisions...
October 2017: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/29056866/gas-phase-protein-salt-bridge-stabilities-from-collisional-activation-and-electron-transfer-dissociation
#6
Zhe Zhang, Richard W Vachet
The gas phase structures of several proteins have been studied by electron transfer dissociation (ETD) with and without prior collisional heating after electrospraying these proteins from native-like solutions into a quadrupole ion trap mass spectrometer. Without prior collisional heating, we find that ETD fragmentation is mostly limited to regions of the protein that are not spanned by the salt bridges known to form in solution. When protein ions are collisionally heated before ETD, new product ions are observed, and in almost all cases, these new ions arise from protein regions that are spanned by the salt bridges...
September 2017: International Journal of Mass Spectrometry
https://www.readbyqxmd.com/read/29049653/effect-of-oral-semaglutide-compared-with-placebo-and-subcutaneous-semaglutide-on-glycemic-control-in-patients-with-type-2-diabetes-a-randomized-clinical-trial
#7
RANDOMIZED CONTROLLED TRIAL
Melanie Davies, Thomas R Pieber, Marie-Louise Hartoft-Nielsen, Oluf K H Hansen, Serge Jabbour, Julio Rosenstock
Importance: Glucagon-like peptide-1 (GLP-1) receptor agonists are effective therapies for the treatment of type 2 diabetes and are all currently available as an injection. Objectives: To compare the effects of oral semaglutide with placebo (primary) and open-label subcutaneous semaglutide (secondary) on glycemic control in patients with type 2 diabetes. Design, Setting, and Patients: Phase 2, randomized, parallel-group, dosage-finding, 26-week trial with 5-week follow-up at 100 sites (hospital clinics, general practices, and clinical research centers) in 14 countries conducted between December 2013 and December 2014...
October 17, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29045079/improvements-in-health-related-quality-of-life-over-3%C3%A2-years-with-liraglutide-3-0%C3%A2-mg-compared-with-placebo-in-participants-with-overweight-or-obesity
#8
R L Kolotkin, B Gabriel Smolarz, H H Meincke, K Fujioka
Previously in the SCALE Obesity and Prediabetes trial, at 1 year, participants with obesity (or overweight with comorbidities) and prediabetes receiving liraglutide 3.0 mg experienced greater improvements in health-related quality of life (HRQoL) than those receiving placebo. The current study extends these findings by examining 3-year changes in HRQoL. HRQoL was assessed using the obesity-specific Impact of Weight on Quality of Life-Lite (IWQOL-Lite) questionnaire, as well as the Short-Form 36 v2 (SF-36) health survey...
October 16, 2017: Clinical Obesity
https://www.readbyqxmd.com/read/29027149/sequencing-larger-intact-proteins-30-70-kda-with-activated-ion-electron-transfer-dissociation
#9
Nicholas M Riley, Michael S Westphall, Joshua J Coon
The analysis of intact proteins via mass spectrometry can offer several benefits to proteome characterization, although the majority of top-down experiments focus on proteoforms in a relatively low mass range (<30 kDa). Recent studies have focused on improving the analysis of larger intact proteins (up to ~75 kDa), but they have also highlighted several challenges to be addressed. One major hurdle is the efficient dissociation of larger protein ions, which often to do not yield extensive fragmentation via conventional tandem MS methods...
October 12, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/29017385/patient-satisfaction-in-the-long-term-effects-of-eustachian-tube-balloon-dilation-is-encouraging
#10
Veera Luukkainen, Matej Vnencak, Antti A Aarnisalo, Jussi Jero, Saku T Sinkkonen
OBJECT: To investigate the long-term effects of balloon Eustachian tuboplasty (BET) from patient's perspective and to discover which symptoms of Eustachian tube dysfunction (ETD) benefit the most from BET. METHOD: We designed a retrospective postal questionnaire based on the seven-item ETD questionnaire (ETDQ-7). Our questionnaire covered the severity of present ETD symptoms in comparison with the preoperative situation, the severity of current overall ear symptoms, and possible surgical interventions after BET...
October 10, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28990834/eustachian-tube-evaluation-in-patients-with-obstructive-sleep-apnea-syndrome
#11
Giuseppe Magliulo, Marco de Vincentiis, Giannicola Iannella, Andrea Ciofalo, Alessandra Manno, Benedetta Pasquariello, Diletta Angeletti, Annalisa Pace, Giampiero Gulotta, Antonella Polimeni
OBJECTIVES: Investigate the presence of Eustachian Tube Dysfunction (ETD) in Obstructive sleep apnea (OSA) patients. Correlate the ET function and the severity of the sleep apnea syndrome. Correlate nasal resistance and nasal mucociliary clearance with the onset of ETD in these patients. MATERIALS AND METHODS: Forty patients affected by OSA were enrolled in our clinical prospective study. Thirty patients were also investigated as a control group. All of the analyzed subjects underwent ENT examination, anterior rhinomanometry and test for mucociliary transport time...
October 9, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28988959/decision-making-frameworks-and-considerations-for-informing-coverage-decisions-for-healthcare-interventions-a-critical-interpretive-synthesis
#12
Rebecca L Morgan, Leah Kelley, Gordon Guyatt, Ana Johnson, John N Lavis
OBJECTIVE: To guide decision-making about whether or not to pay for a new healthcare intervention, a number of existing frameworks systematically weigh scientific evidence, cost, and social and ethical values. Each framework has strengths and limitations. This study aims to review and summarize available frameworks, and generate an integrated framework, if and where applicable, highlighting particular issues faced with expensive but effective and desirable healthcare interventions. STUDY DESIGN AND SETTING: We conducted a critical interpretive synthesis to inform decision-making about healthcare interventions...
October 5, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28966899/study-of-ion-dynamics-by-electron-transfer-dissociation-alkali-metals-as-targets
#13
Shigeo Hayakawa
High energy collision processes for singly charged positive ions using an alkali metal target are confirmed, as a charge inversion mass spectrometry, to occur by electron transfers in successive collisions and the dissociation processes involve the formation of energy-selected neutral species from near-resonant neutralization with alkali metal targets. A doubly charged thermometer molecule was made to collide with alkali metal targets to give singly and doubly charged positive ions. The internal energy resulting from the electron transfer with the alkali metal target was very narrow and centered at a particular energy...
2017: Mass Spectrometry
https://www.readbyqxmd.com/read/28961009/preparation-of-labile-ni-cyclam-cations-in-the-gas-phase-using-electron-transfer-reduction-through-ion-ion-recombination-in-an-ion-trap-and-structural-characterization-with-vibrational-spectroscopy
#14
Musleh U Munshi, Stephanie M Craig, Giel Berden, Jonathan Martens, Andrew F DeBlase, David J Foreman, Scott A McLuckey, Jos Oomens, Mark A Johnson
Gas-phase ion chemistry methods that capture and characterize the degree of activation of small molecules in the active sites of homogeneous catalysts form a powerful new tool to unravel how ligand environments affect reactivity. A key roadblock in this development, however, is the ability to generate the fragile metal oxidation states that are essential for catalytic activity. Here we demonstrate the preparation of the key Ni(I) center in the widely used cyclam scaffold using ion-ion recombination as a gas-phase alternative to electrochemical reduction...
October 19, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28946704/emergence-of-nasal-carriage-of-st80-and-st152-pvl-staphylococcus-aureus-isolates-from-livestock-in-algeria
#15
Amir Agabou, Zouleikha Ouchenane, Christelle Ngba Essebe, Salim Khemissi, Mohamed Tedj Eddine Chehboub, Ilyes Bey Chehboub, Albert Sotto, Catherine Dunyach-Remy, Jean-Philippe Lavigne
The spread of toxinogenic Staphylococcus aureus is a public health problem in Africa. The objectives of the study were to investigate the rate of S. aureus nasal carriage and molecular characteristics of these strains in livestock and humans in three Algerian provinces. Nasal samples were collected from camels, horses, cattle, sheep and monkeys, as well as humans in contact with them. S. aureus isolates were genotyped using DNA microarray. The rate of S. aureus nasal carriage varied between species: camels (53%), humans and monkeys (50%), sheep (44...
September 25, 2017: Toxins
https://www.readbyqxmd.com/read/28945460/estimation-of-rates-of-reactions-triggered-by-electron-transfer-in-top-down-mass-spectrometry
#16
Michał Aleksander Ciach, Mateusz Krzysztof Łącki, Błażej Miasojedow, Frederik Lermyte, Dirk Valkenborg, Frank Sobott, Anna Gambin
Electron transfer dissociation (ETD) is a versatile technique used in mass spectrometry for the high-throughput characterization of proteins. It consists of several concurrent reactions triggered by the transfer of an electron from its anion source to sample cations. Transferring an electron causes peptide backbone cleavage while leaving labile post-translational modifications intact. The obtained fragmentation spectra provide valuable information for sequence and structure analyses. In this study, we propose a formal mathematical model of the ETD fragmentation process in the form of a system of stochastic differential equations describing its joint dynamics...
September 25, 2017: Journal of Computational Biology: a Journal of Computational Molecular Cell Biology
https://www.readbyqxmd.com/read/28934978/adaptation-of-the-2015-american-college-of-rheumatology-treatment-guideline-for-rheumatoid-arthritis-for-the-eastern-mediterranean-region-an-exemplar-of-the-grade-adolopment
#17
Andrea Darzi, Manale Harfouche, Thurayya Arayssi, Samar Alemadi, Khalid A Alnaqbi, Humeira Badsha, Farida Al Balushi, Bassel Elzorkany, Hussein Halabi, Mohammed Hamoudeh, Wissam Hazer, Basel Masri, Mohammed A Omair, Imad Uthman, Nelly Ziade, Jasvinder A Singh, Robin Christiansen, Peter Tugwell, Holger J Schünemann, Elie A Akl
BACKGROUND: It has been hypothesized that adaptation of health practice guidelines to the local setting is expected to improve their uptake and implementation while cutting on required resources. We recently adapted the published American College of Rheumatology (ACR) Rheumatoid Arthritis (RA) treatment guideline to the Eastern Mediterranean Region (EMR). The objective of this paper is to describe the process used for the adaptation of the 2015 ACR guideline on the treatment of RA for the EMR...
September 21, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28932996/what-hinders-electron-transfer-dissociation-etd-of-dna-cations
#18
Yvonne Hari, Christian J Leumann, Stefan Schürch
Radical activation methods, such as electron transfer dissociation (ETD), produce structural information complementary to collision-induced dissociation. Herein, electron transfer dissociation of 3-fold protonated DNA hexamers was studied to gain insight into the fragmentation mechanism. The fragmentation patterns of a large set of DNA hexamers confirm cytosine as the primary target of electron transfer. The reported data reveal backbone cleavage by internal electron transfer from the nucleobase to the phosphate linker leading either to a•/w or d/z• ion pairs...
September 20, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28918652/investigation-of-pump-compatibility-of-fast-acting-insulin-aspart-in-subjects-with-type-1-diabetes
#19
Eric Zijlstra, Marek Demissie, Tina Graungaard, Tim Heise, Leszek Nosek, Bruce Bode
BACKGROUND: Ultra-fast-acting insulins, such as fast-acting insulin aspart (faster aspart), have pharmacokinetic properties that may be advantageous for patients using continuous subcutaneous insulin infusion (CSII), provided that they are compatible with and safe to use in CSII. METHODS: Randomized, double-blind, parallel-group, actively controlled trial evaluating compatibility, efficacy, and safety of faster aspart in adults with type 1 diabetes using their own MiniMed Paradigm pump with Quick-Set or Silhouette infusion sets...
September 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28917831/-grade-evidence-to-decision-etd-frameworks-a-systematic-and-transparent-approach-to-making-well-informed-healthcare-choices-2-clinical-practice-guidelines
#20
Pablo Alonso-Coello, Andrew D Oxman, Jenny Moberg, Romina Brignardello-Petersen, Elie A Akl, Marina Davoli, Shaun Treweek, Reem A Mustafa, Per O Vandvik, Joerg Meerpohl, Gordon H Guyatt, Holger J Schünemann
Clinicians do not have the time or resources to consider the underlying evidence for the myriad decisions they must make each day and, as a consequence, rely on recommendations from clinical practice guidelines. Guideline panels should consider all the relevant factors (criteria) that influence a decision or recommendation in a structured, explicit, and transparent way and provide clinicians with clear and actionable recommendations. In this article, we will describe the Evidence to Decision (EtD) frameworks for clinical practice recommendations...
September 13, 2017: Gaceta Sanitaria
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