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Evren Erkul, Umamaheswar Duvvuri, Deepak Mehta, Utku Aydil
Pediatric robotic surgery is a relatively new technology that has been shown to be safe and feasible for a number of pediatric procedures. Our literature analysis was performed using Pubmed database between January 2005 and December 2015, using key words: "robotic," "robotic surgery," "TORS," "pediatric," "children," "head and neck," and "da Vinci". We selected only publications in English. Eight published reports met the selection criteria. We totally found 41 patients, and the age range was between 2 months and 19 years...
December 21, 2016: European Archives of Oto-rhino-laryngology
Toni M Brand, Stefan Hartmann, Neil E Bhola, Noah D Peyser, Hua Li, Yan Zeng, Erin Isaacson Wechsler, Max V Ranall, Sourav Bandyopadhyay, Umamaheswar Duvvuri, Theresa M LaVallee, Richard C K Jordan, Daniel E Johnson, Jennifer R Grandis
PURPOSE: Human papillomavirus (HPV) 16 plays an etiologic role in a growing subset of HNSCCs, where viral expression of the E6 and E7 oncoproteins are necessary for tumor growth and maintenance. Although patients with HPV(+) tumors have a more favorable prognosis, there are currently no HPV-selective therapies. Recent studies identified differential receptor tyrosine kinase (RTK) profiles in HPV(+) vs. HPV(-) tumors. One such RTK, HER3, is overexpressed and interacts with phosphoinositide 3-kinase (PI3K) in HPV(+) tumors...
December 16, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Padmaraj Duvvuri, Jeffery Spray, Marcia Brackbill, Abhijit Duggal
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
Raj Kumar Sharma, Kanchan Sonkar, Neeraj Sinha, Pradeep Rebala, Ahmad Ebrah Albani, Anu Behari, Duvvuri Nageshwar Reddy, Alvina Farooqui, Vinay Kumar Kapoor
BACKGROUND: Gallstones (GS) associated diseases are among the most recurrent and frequent diseases delineated in India and United Arab Emirates. Several reports suggest that the association of GS with gallbladder cancer (GBC) is very high in Northern part of India; however, its occurrence in UAE and Southern part of India is notably low. Therefore, in the present study, we aimed to perform compositional analysis of GS in three different geographical areas by Solid State Nuclear Magnetic Resonance and Fourier Transformed Infrared spectroscopy...
2016: PloS One
Harsha Moole, Jaymon Patel, Zohair Ahmed, Abhiram Duvvuri, Sreekar Vennelaganti, Vishnu Moole, Sowmya Dharmapuri, Raghuveer Boddireddy, Pratyusha Yedama, Naveen Bondalapati, Achuta Uppu, Prashanth Vennelaganti, Srinivas Puli
AIM: To evaluate annual incidence of low grade dysplasia (LGD) progression to high grade dysplasia (HGD) and/or esophageal adenocarcinoma (EAC) when diagnosis was made by two or more expert pathologists. METHODS: Studies evaluating the progression of LGD to HGD or EAC were included. The diagnosis of LGD must be made by consensus of two or more expert gastrointestinal pathologists. Articles were searched in Medline, Pubmed, and Embase. Pooled proportions were calculated using fixed and random effects model...
October 21, 2016: World Journal of Gastroenterology: WJG
R L Ferris, J L Geiger, S Trivedi, N C Schmitt, D E Heron, J T Johnson, S Kim, U Duvvuri, D A Clump, J E Bauman, J P Ohr, W E Gooding, A Argiris
BACKGROUND: Treatment intensification for resected, high-risk, head and neck squamous cell carcinoma (HNSCC) is an area of active investigation with novel adjuvant regimens under study. In this trial, the epidermal growth-factor receptor (EGFR) pathway was targeted using the IgG2 monoclonal antibody panitumumab in combination with cisplatin chemoradiotherapy (CRT) in high-risk, resected HNSCC. PATIENTS AND METHODS: Eligible patients included resected pathologic stage III or IVA squamous cell carcinoma of the oral cavity, larynx, hypopharynx, or human-papillomavirus (HPV)-negative oropharynx, without gross residual tumor, featuring high-risk factors (margins <1 mm, extracapsular extension, perineural or angiolymphatic invasion, or ≥2 positive lymph nodes)...
December 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
D C Ling, B V Chapman, J Kim, G W Choby, P Kabolizadeh, D A Clump, R L Ferris, S Kim, S Beriwal, D E Heron, U Duvvuri
OBJECTIVE: It has been postulated that treatment outcomes are similar between transoral robotic surgery (TORS) and definitive chemoradiation (CRT) for oropharyngeal squamous cell carcinomas (OPSCC). We compared oncologic and quality of life (QOL) outcomes between definitive CRT and definitive TORS. MATERIALS AND METHODS: An observational comparison study was performed on 92 patients treated with TORS±adjuvant therapy and 46 patients treated with definitive CRT between July 2005 and January 2016...
October 2016: Oral Oncology
D C Ling, J Vargo, R L Ferris, J Ohr, D A Clump, W Y W Yau, U Duvvuri, S Kim, J T Johnson, J E Bauman, B F Branstetter, D E Heron
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Harsha Moole, Sirish Dharmapuri, Abhiram Duvvuri, Sowmya Dharmapuri, Raghuveer Boddireddy, Vishnu Moole, Prathyusha Yedama, Naveen Bondalapati, Achuta Uppu, Charan Yerasi
Background. Palliation in advanced unresectable hilar malignancies can be achieved by endoscopic (EBD) or percutaneous transhepatic biliary drainage (PTBD). It is unclear if one approach is superior to the other in this group of patients. Aims. Compare clinical outcomes of EBD versus PTBD. Methods. (i) Study Selection Criterion. Studies using PTBD and EBD for palliation of advanced unresectable hilar malignancies. (ii) Data Collection and Extraction. Articles were searched in Medline, PubMed, and Ovid journals...
2016: Canadian Journal of Gastroenterology & Hepatology
Garret Ma, Idris Samad, Kevin Motz, Linda X Yin, Madhavi V Duvvuri, Dacheng Ding, Daryan R Namba, Jennifer H Elisseeff, Maureen R Horton, Alexander T Hillel
OBJECTIVES/HYPOTHESIS: Laryngotracheal stenosis (LTS) is a chronic fibrotic disease characterized by fibroblast proliferation, collagen deposition, and matrix remodeling in the lamina propria of the larynx and/or trachea. Current medical therapies are limited by a poor understanding of the effector cell's (fibroblasts) cellular biology and metabolism. The purpose of this study was to compare cellular proliferation, function, and metabolism between normal and LTS-derived fibroblasts in vitro...
September 1, 2016: Laryngoscope
William G Albergotti, Kara S Davis, Shira Abberbock, Julie E Bauman, James Ohr, David A Clump, Dwight E Heron, Umamaheswar Duvvuri, Seungwon Kim, Jonas T Johnson, Robert L Ferris
BACKGROUND: Pretreatment body mass index (BMI) >25kg/m(2) is a positive prognostic factor in patients with head and neck cancer. Previous studies have not been adequately stratified by human papilloma virus (HPV) status or subsite. Our objective is to determine prognostic significance of pretreatment BMI on overall survival in HPV+ oropharyngeal squamous cell carcinoma (OPSCC). METHODS: This is a retrospective review of patients with HPV+ OPSCC treated between 8/1/2006 and 8/31/2014...
September 2016: Oral Oncology
Chengyuan Wang, Summit Kundaria, Juan Fernandez-Miranda, Umamaheswar Duvvuri
OBJECTIVES/HYPOTHESIS: To illustrate detailed anatomy of the extracranial portion of the glossopharyngeal nerve in the parapharyngeal space as encountered during transoral surgery. STUDY DESIGN: Prospective cadaveric dissection. All dissections were performed transorally and confirmed with transcervical dissection. METHODS: Eight color-injected cadaveric heads (16 sides) were dissected to demonstrate the course and anatomy of the glossopharyngeal nerve...
September 2016: Laryngoscope
Diane C Ling, John A Vargo, Robert L Ferris, James Ohr, David A Clump, Wai-Ying Wendy Yau, Umamaheswar Duvvuri, Seungwon Kim, Jonas T Johnson, Julie E Bauman, Barton F Branstetter, Dwight E Heron
PURPOSE: To report a 10-year update of our institutional experience with stereotactic body radiation therapy (SBRT) for reirradiation of locally recurrent head and neck cancer, focusing on predictors of toxicity. METHODS AND MATERIALS: A retrospective review was performed on 291 patients treated with SBRT for recurrent, previously irradiated head and neck cancer between April 2002 and March 2013. Logistic regression analysis was performed to identify predictors of severe acute and late toxicity...
July 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Neil Gildener-Leapman, Jeehong Kim, Shira Abberbock, Garret W Choby, Rajarsi Mandal, Umamaheswar Duvvuri, Robert L Ferris, Seungwon Kim
BACKGROUND: The purpose of this study was to describe how the up-front transoral robotic surgery (TORS) approach could be used to individually tailor adjuvant therapy based on surgical pathology. METHODS: Between January 2009 and December 2013, 76 patients received TORS for oropharyngeal squamous cell carcinoma (OPSCC). Clinical predictors of adjuvant therapy were analyzed and comparisons were made between recommended treatment guidelines for up-front surgery versus definitive nonsurgical approaches...
August 2016: Head & Neck
A Argiris, J E Bauman, J Ohr, W E Gooding, D E Heron, U Duvvuri, G J Kubicek, D M Posluszny, M Vassilakopoulou, S Kim, J R Grandis, J T Johnson, M K Gibson, D A Clump, J T Flaherty, S I Chiosea, B Branstetter, R L Ferris
BACKGROUND: We previously reported the safety of concurrent cetuximab, an antibody against epidermal growth factor receptor (EGFR), pemetrexed, and radiation therapy (RT) in patients with locally advanced squamous cell carcinoma of the head and neck (SCCHN). In this non-comparative phase II randomized trial, we evaluated this non-platinum combination with or without bevacizumab, an inhibitor of vascular endothelial growth factor (VEGF). PATIENTS AND METHODS: Patients with previously untreated stage III-IVB SCCHN were randomized to receive: conventionally fractionated radiation (70 Gy), concurrent cetuximab, and concurrent pemetrexed (arm A); or the identical regimen plus concurrent bevacizumab followed by bevacizumab maintenance for 24 weeks (arm B)...
August 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
Jason I Kass, Laureano Giraldez, William Gooding, Garret Choby, Seungwon Kim, Brett Miles, Marita Teng, Andrew G Sikora, Jonas T Johnson, Eugene N Myers, Umamaheswar Duvvuri, Eric M Genden, Robert L Ferris
BACKGROUND: The purpose of this study was to characterize oncologic outcomes in early (T1-T2, N0) and intermediate (T1-T2, N1) oropharyngeal squamous cell carcinoma (SCC) after surgery. METHODS: Patients with oropharyngeal SCC treated with surgery were identified from 2 academic institutions. RESULTS: Of 188 patients, 143 met the inclusion criteria. Eighty-six (60%) had T1 to T2 N0 and 57 (40%) had T1 to T2 N1 disease. Sixty-five patients (45%) underwent a robotic-assisted resection, whereas the remaining had transoral (n = 60; 42%), mandible-splitting (n = 11; 8%), or transhyoid approaches (n = 7; 5%)...
October 2016: Head & Neck
Venkata R Duvvuri, Xianding Deng, Sarah Teatero, Nader Memari, Taryn Athey, Nahuel Fittipaldi, Jonathan B Gubbay
The introduction of pneumococcal conjugate vaccines has led to the emergence of non-vaccine serotypes, which contributed to invasive pneumococcal disease in Canada and worldwide. A significant increase in the prevalence of non-13-valent pneumococcal conjugate vaccine (PCV-13)-included serotypes 22F, 15A, and 8 was observed from 2009 to 2013 in Ontario (all p values<0.01). In this study, whole genome sequencing was conducted on the 25 isolates of serotype 22F, seven of 15A and 10 of 8 to investigate the population structure and antibiotic resistance...
August 2016: Infection, Genetics and Evolution
Neil D Gross, F Christopher Holsinger, J Scott Magnuson, Umamaheswar Duvvuri, Eric M Genden, Tamer Ah Ghanem, Kathleen L Yaremchuk, David Goldenberg, Matthew C Miller, Eric J Moore, Luc Gt Morris, James Netterville, Gregory S Weinstein, Jeremy Richmon
Training and credentialing for robotic surgery in otolaryngology - head and neck surgery is currently not standardized, but rather relies heavily on industry guidance. This manuscript represents a comprehensive review of this increasingly important topic and outlines clear recommendations to better standardize the practice. The recommendations provided can be used as a reference by individuals and institutions alike, and are expected to evolve over time. © 2016 Wiley Periodicals, Inc. Head Neck 38: E151-E158...
April 2016: Head & Neck
Mark R Gilbert, Arun Sharma, Nicole C Schmitt, Jonas T Johnson, Robert L Ferris, Umamaheswar Duvvuri, Seungwon Kim
IMPORTANCE: Salivary duct carcinoma is a rare, aggressive malignancy of the salivary glands. Owing to its rare nature, clinical data are limited, and only a few clinical studies comprise more than 50 patients. OBJECTIVE: To review the University of Pittsburgh Medical Center's experience with salivary duct carcinoma over a 20-year period, focusing on demographics, presentation, treatment, and outcome. DESIGN, SETTING, AND PARTICIPANTS: This investigation was a retrospective cohort study in a multihospital institution with tertiary referral...
May 1, 2016: JAMA Otolaryngology—Head & Neck Surgery
Nathan L Liang, Brian D Guedes, Umamaheswar Duvvuri, Michael J Singh, Rabih A Chaer, Michel S Makaroun, Ulka Sachdev
BACKGROUND: The purpose of this study was to examine outcomes of a patient cohort undergoing intervention for carotid blowout syndrome associated with head and neck cancer. METHODS: Patients with head and neck cancer who presented with carotid distribution bleeding from 2000 to 2014 were identified in the medical record. Primary outcomes were short- and midterm mortality and recurrent bleeding. Standard statistical methods and survival analysis were used to analyze study population characteristics and outcomes...
June 2016: Journal of Vascular Surgery
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