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Kyu Seung Lee, Jaeho Shim, Hyunbok Lee, Sang-Youp Yim, Basavaraj Angadi, Byungkwon Lim, Dong Ick Son
Hybrid organic-Red-Green-Blue (RGB) color quantum dots were incorporated into consolidated p(polymer)-i(RGB quantum dots)-n(small molecules) junction structures to fabricate a single active layer for a light emitting diode device for white electroluminescence. The semiconductor RGB quantum dots, as an intrinsic material, were electrostatically bonded between functional groups of the p-type polymer organic material core surface and the n-type small molecular organic material shell surface. The ZnCdSe/ZnS and CdSe/ZnS quantum dots distributed uniformly and isotropically surrounding the polymer core which in turn was surrounded by small molecular organic materials...
June 8, 2018: Nanoscale
Sharon M Sagnella, Jennifer Trieu, Himanshu Brahmbhatt, Jennifer A MacDiarmid, Alex MacMillan, Renee M Whan, Christopher M Fife, Joshua A McCarroll, Andrew J Gifford, David S Ziegler, Maria Kavallaris
Advanced stage neuroblastoma is an aggressive disease with limited treatment options for patients with drug-resistant tumors. Targeted delivery of chemotherapy for pediatric cancers offers promise to improve treatment efficacy and reduce toxicity associated with systemic chemotherapy. The EnGeneIC Dream Vector (EDVTM ) is a nanocell, which can package chemotherapeutic drugs and target tumors via attachment of bispecific proteins to the surface of the nanocell. Phase I trials in adults with refractory tumors have shown an acceptable safety profile...
May 2018: Molecular Cancer Therapeutics
Kevin Kwan, Julia R Schneider, Andrew Kobets, John A Boockvar
No abstract text is available yet for this article.
March 1, 2018: Neurosurgery
Mohamed A Alfaleh, Christopher B Howard, Ilya Sedliarou, Martina L Jones, Reema Gudhka, Natasha Vanegas, Jocelyn Weiss, Julia H Suurbach, Christopher J de Bakker, Michael R Milne, Bree A Rumballe, Jennifer A MacDiarmid, Himanshu Brahmbhatt, Stephen M Mahler
Human malignant mesothelioma is a chemoresistant tumour that develops from mesothelial cells, commonly associated with asbestos exposure. Malignant mesothelioma incidence rates in European countries are still rising and Australia has one of the highest burdens of malignant mesothelioma on a population basis in the world. Therapy using systemic delivery of free cytotoxic agents is associated with many undesirable side effects due to non-selectivity, and is thus dose-limited which limits its therapeutic potential...
2017: PloS One
Rui Hao, Yunshan Fan, Bo Zhang
The electrochemical interface is an ultrathin interfacial region between the electrode surface and the electrolyte solution and is often characterized by numerous dynamic processes, such as solvation and desolvation, heterogeneous electron transfer, molecular adsorption and desorption, diffusion, and surface rearrangement. Many of these processes are driven and modulated by the presence of a large interfacial potential gradient. The study and better understanding of the electrochemical interface is important for designing better electrochemical systems where their applications may include batteries, fuel cells, electrocatalytic water splitting, corrosion protection, and electroplating...
August 24, 2017: Journal of the American Chemical Society
Noah Ritzmann, Johannes Thoma, Stephan Hirschi, David Kalbermatter, Dimitrios Fotiadis, Daniel J Müller
One major objective of synthetic biology is the bottom-up assembly of minimalistic nanocells consisting of lipid or polymer vesicles as architectural scaffolds and of membrane and soluble proteins as functional elements. However, there is no reliable method to orient membrane proteins reconstituted into vesicles. Here, we introduce a simple approach to orient the insertion of the light-driven proton pump proteorhodopsin (PR) into liposomes. To this end, we engineered red or green fluorescent proteins to the N- or C-terminus of PR, respectively...
September 19, 2017: Biophysical Journal
Zhao Cang, Zhong Ying, Qiao Yu
The dynamic indentation behaviors of monolithic silica nanofoams of various porosities are investigated. When the pore size is on the nm scale, as the porosity increases, despite the decrease in mass density, the resistance offered by silica nanofoam to dynamic indentation is maintained at a high level, higher than the resistance of solid silica or regular porous silica. This phenomenon is related to the fast collapse of nanocells, which produces a locally hardened region and significantly increases the volume of material involved in impact energy dissipation...
April 21, 2017: Scientific Reports
Md Habban Akhter, Saima Amin
Squamous cell carcinoma of skin has become an important matter of discussion worldwide due to high number of deaths. Treatment of such cancer involves use of drugs (chemotherapy) along with surgery or radiation therapy. The combination therapy is always preferred than single treatment modality due to poor internalization of most of the chemotherapeutics in the affected cells. Now a days, nanoparticle based drug delivery to squamous cell carcinoma is equanimous to become a leading therapeutic approach for cancer treatment...
September 6, 2016: Current Drug Delivery
Anthony R Glover, Jing Ting Zhao, Anthony J Gill, Jocelyn Weiss, Nancy Mugridge, Edward Kim, Alex L Feeney, Julian C Ip, Glen Reid, Stephen Clarke, Patsy S H Soon, Bruce G Robinson, Himanshu Brahmbhatt, Jennifer A MacDiarmid, Stan B Sidhu
Adrenocortical carcinoma (ACC) has a poor prognosis with significant unmet clinical need due to late diagnosis, high rates of recurrence/metastasis and poor response to conventional treatment. Replacing tumor suppressor microRNAs (miRNAs) offer a novel therapy, however systemic delivery remains challenging. A number of miRNAs have been described to be under-expressed in ACC however it is not known if they form a part of ACC pathogenesis. Here we report that microRNA-7-5p (miR-7) reduces cell proliferation in vitro and induces G1 cell cycle arrest...
November 3, 2015: Oncotarget
Xiaoxi Qiao, Xiangjun Zhang, Yu Tian, Yonggang Meng
Nanorheology and boundary slip play an important role in the micro/nanofluidics, and micro/nano-electromechanical systems, especially for research on DNA, proteins and polymers. Herein, a nanoscale confinement structure, called a nanocell, is established by assembling a parallel plate on the quartz crystal microbalance (QCM) chip to study the nanorheology of liquids and the boundary slip on the interface. The corresponding analytical models are established and verified experimentally with high consistency. We reveal that the responses of QCM with the nanocell assembled are dependent on the nanocell confinement thickness, the acoustic impedance of the nanocell lid (parallel plate), as well as the boundary slip on the interface...
March 21, 2015: Physical Chemistry Chemical Physics: PCCP
Pinar Avci, S Sibel Erdem, Michael R Hamblin
Photodynamic therapy (PDT) is a promising treatment modality for cancer with possible advantages over current treatment alternatives. It involves combination of light and a photosensitizer (PS), which is activated by absorption of specific wavelength light and creates local tissue damage through generation of reactive oxygen species (ROS) that induce a cascade of cellular and molecular events. However, as of today, PDT is still in need of improvement and nanotechnology may play a role. PDT frequently employs PS with molecular structures that are highly hydrophobic, water insoluble and prone to aggregation...
September 2014: Journal of Biomedical Nanotechnology
Karin Taylor, Christopher B Howard, Martina L Jones, Ilya Sedliarou, Jennifer MacDiarmid, Himanshu Brahmbhatt, Trent P Munro, Stephen M Mahler
There are many design formats for bispecific antibodies (BsAbs), and the best design choice is highly dependent on the final application. Our aim was to engineer BsAbs to target a novel nanocell (EnGeneIC Delivery Vehicle or EDV(TM)nanocell) to the epidermal growth factor receptor (EGFR). EDV(TM)nanocells are coated with lipopolysaccharide (LPS), and BsAb designs incorporated single chain Fv (scFv) fragments derived from an anti-LPS antibody (1H10) and an anti-EGFR antibody, ABX-EGF. We engineered various BsAb formats with monovalent or bivalent binding arms and linked scFv fragments via either glycine-serine (G4S) or Fc-linkers...
2015: MAbs
Pornprom Muangman, Supaporn Opasanon, Supaparn Suwanchot, Orapin Thangthed
Microbial cellulose is a natural polymer that can hold a quantity of water without any disconformities. Therefore, it is proposed for use as wound dressing material. We report a case of 28% total body surface area partial-thickness flame burn: approximately 4.5% superficial partial-thickness burns on anterior face and 23.5% combined superficial and deep partial-thickness burns on both upper arms and anterior trunk. A microbial cellulose dressing, Nanocell (Thai Nano Cellulose Co Ltd, Bangkok, Thailand), was applied to the face wound only once, without any further dressing change...
March 2011: Journal of the American College of Certified Wound Specialists
Shaker A Mousa, Dhruba J Bharali
The application of nanotechnology to biomedicine, particularly in cancer diagnosis and treatment, promises to have a profound impact on healthcare. The exploitation of the unique properties of nano-sized particles for cancer therapeutics is most popularly known as nanomedicine. The goals of this review are to discuss the current state of nanomedicine in the field of cancer detection and the subsequent application of nanotechnology to treatment. Current cancer detection methods rely on the patient contacting their provider when they feel ill, or relying on non-specific screening methods, which unfortunately often result in cancers being detected only after it is too late for effective treatment...
2011: Cancers
B Y Zong, J Y Goh, Z B Guo, P Luo, C C Wang, J J Qiu, P Ho, Y J Chen, M S Zhang, G C Han
A novel approach to the fabrication of metal-cell-metal trilayer memory devices was demonstrated by using only two cycles of lithography and dry-etch procedures. The fabricated ultrahigh density crossbar devices can be scaled down to ≤70 nm in half-pitch without alignment issues. Depending on the different dry-etch mechanisms in transferring high and low density nanopatterns, suitable dry-etch angles and methods are studied for the transfer of high density nanopatterns. Some novel process methods have also been developed to eliminate the sidewall and other conversion obstacles for obtaining high density of uniform metallic nanopatterns...
June 21, 2013: Nanotechnology
Tu'uhevaha J Kaitu'u-Lino, Scott Pattison, Louie Ye, Laura Tuohey, Pavel Sluka, Jennifer MacDiarmid, Himanshu Brahmbhatt, Terrence Johns, Andrew W Horne, Jeremy Brown, Stephen Tong
Abnormal trophoblast growth can cause life-threatening disorders such as ectopic pregnancy, choriocarcinoma, and placenta accreta. EnGeneIC Delivery Vehicles (EDVs) are nanocells that can promote tissue-specific delivery of drugs and may be useful to medically treat such disorders. The objective of this study was to determine whether EDVs loaded with the chemotherapeutic doxorubicin and targeting the epidermal growth factor receptor (EGFR, very highly expressed on the placental surface) can regress placental cells in vitro, ex vivo, and in vivo...
February 2013: Endocrinology
Sabrina A Schreiner, Katharina Hoelzle, Regina Hofmann-Lehmann, Anja Hamburger, Max M Wittenbrink, Manuela M Kramer, Albina Sokoli, Kathrin M Felder, Katrin Groebel, Ludwig E Hoelzle
Mycoplasma suis belongs to haemotrophic mycoplasmas (HMs) which cause infectious anaemia in a large variety of mammals. To date, no in vitro cultivation system for M. suis or other HMs has been established. We hypothesised that M. suis could grow in classical Mycoplasma media supplemented with nutrients (e.g. glucose, iron-binding proteins) which are naturally available from its host environment, the porcine blood. Blood from experimentally M. suis-infected pigs was used to inoculate either standard SP-4 Mycoplasma medium supplemented with iron-binding proteins (transferrin, haemin, and haemoglobin) or glucose-enriched Hayflick Mycoplasma medium...
November 9, 2012: Veterinary Microbiology
Armen Sargsyan, Grant Hakhumyan, Claude Leroy, Yevgenya Pashayan-Leroy, Aram Papoyan, David Sarkisyan
A simple and efficient scheme based on a one-dimensional nanometric-thin cell filled with Rb and strong permanent ring magnets allows direct observation of the hyperfine Paschen-Back regime on the D(1) line in the 0.5-0.7 T magnetic field. Experimental results are perfectly consistent with the theory. In particular, with σ(+) laser excitation, the slopes of the B-field dependence of frequency shifts for all 10 individual transitions of (85,87)Rb are the same and equal to 18.6 MHz/mT. Possible applications for magnetometry with submicron spatial resolution and tunable atomic frequency references are discussed...
April 15, 2012: Optics Letters
A A Robson
It is crucial that emergent technologies create foods that help prevent the causal mechanisms of the diet induced disease epidemic. Food nanotechnology could create modem convenience foods that mimic and improve on the nutritional value of the most nutritious cooked wild foods for humans. Structuring a solid processed food similar to a celery stalk using self-assembled, water-filled, edible nanocells or nanotubes would substantially lower its energy density (<1.6 kcal g(-1)). Food technologists could harness the natural turgor force to produce a firm chocolate bar, biscuit or breakfast cereal with a good bite, without altering the appearance or taste of the product...
2011: Nutrition and Health
Jack T Trevors
This article discusses the hypothesized composition and organization of cytoplasm in prebiotic cells from a theoretical perspective and also based upon what is currently known about bacterial cytoplasm. It is unknown if the first prebiotic, microscopic scale, cytoplasm was initially contained within a primitive, continuous, semipermeable membrane, or was an uncontained gel substance, that later became enclosed by a continuous membrane. Another possibility is that the first cytoplasm in prebiotic cells and a primitive membrane organized at the same time, permitting a rapid transition to the first cell(s) capable of growth and division, thus assisting with the emergence of life on Earth less than a billion years after the formation of the Earth...
2011: International Journal of Molecular Sciences
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