Xiangyun Zhang, Yue Zhang, Ran Zhang, Xinbang Jiang, Adam C Midgley, Qiqi Liu, Helong Kang, Jin Wu, Anila Khalique, Meng Qian, Di An, Jing Huang, Lailiang Ou, Qiang Zhao, Jie Zhuang, Xiyun Yan, Deling Kong, Xinglu Huang
Restoration of sufficient blood supply for the treatment of ischemia remains a significant scientific and clinical challenge. Here, we introduce a cell-like nanoparticle delivery technology that is capable of recapitulating multiple cell functions for the spatiotemporal triggering of vascular regeneration. Specifically, a copper-containing protein was successfully prepared using a recombinant protein scaffold based on a de novo design strategy, which facilitated the timely release of nitric oxide (NO) and improved accumulation of particles within ischemic tissues...
February 2, 2022: Advanced Materials