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Onodera’s Prognostic Nutritional Index

Gan-Bao Wei, Yao-Yong Lu, Rong-Wei Liao, Qing-Sheng Chen, Kun-Qiang Zhang
OBJECTIVE: This study aimed to investigate the prognostic value of Onodera's prognostic nutritional index (PNI) in patients with metastatic nasopharyngeal carcinoma (NPC). METHODS: A total of 187 patients with metastatic NPC treated with cisplatin-based chemotherapy were retrospectively reviewed. The PNI was calculated using the following formula: serum albumin level (gram per liter) +0.005× peripheral lymphocyte count (per cubic millimeter). A receiver operating characteristics curve for overall survival (OS) with the highest Youden index was determined to calculate the best cutoff value of PNI...
2016: OncoTargets and Therapy
Hiromitsu Ban, Shigeki Bamba, Atsushi Nishida, Osamu Inatomi, Makoto Shioya, Ken-Ichiro Takahashi, Hirotsugu Imaeda, Masaki Murata, Masaya Sasaki, Tomoyuki Tsujikawa, Akira Andoh
Calcineurin inhibitors (CNIs) such as cyclosporine A (CSA) and tacrolimus (FK506) are often used as a second-line drug for steroid-refractory or steroid-dependent patients with ulcerative colitis (UC). The aim of the present study was to determine the prognostic factors for early colectomy. A total of 85 hospitalized patients with UC (CSA, 50 patients; FK506, 35 patients) were enrolled. Colectomy carried out within 60 days of starting CNI therapy was defined as 'early colectomy'. To assess the prognostic factors affecting early colectomy, clinical practical variables, including the Onodera-prognostic nutritional index (O-PNI): 10xAlb+0...
August 2016: Experimental and Therapeutic Medicine
Matthew S Broggi, Dattatraya Patil, Yoram Baum, Peter T Nieh, Mehrdad Alemozaffar, John G Pattaras, Kenneth Ogan, Viraj A Master
OBJECTIVES: To evaluate the relationship between the Onodera Prognostic Nutritional Index (OPNI) and overall survival, as well as recurrence-free survival, in clear cell renal cell carcinoma patients following nephrectomy. MATERIALS AND METHODS: 341 patients who underwent nephrectomy for ccRCC were analyzed. The optimum OPNI cut off score of 44.7 was determined by Receiver Operating Characteristic analysis and patients were placed in either the low or high OPNI group, with OPNI values of ≤ 44...
July 15, 2016: Urology
Mitsuro Kanda, Akira Mizuno, Chie Tanaka, Daisuke Kobayashi, Michitaka Fujiwara, Naoki Iwata, Masamichi Hayashi, Suguru Yamada, Goro Nakayama, Tsutomu Fujii, Hiroyuki Sugimoto, Masahiko Koike, Hideki Takami, Yukiko Niwa, Kenta Murotani, Yasuhiro Kodera
Evidence indicates that impaired immunocompetence and nutritional status adversely affect short-term and long-term outcomes of patients with cancer. We aimed to evaluate the clinical significance of preoperative immunocompetence and nutritional status according to Onodera's prognostic nutrition index (PNI) among patients who underwent curative gastrectomy for gastric cancer (GC).This study included 260 patients with stage II/III GC who underwent R0 resection. The predictive values of preoperative nutritional status for postoperative outcome (morbidity and prognosis) were evaluated...
June 2016: Medicine (Baltimore)
Wen Luo, Yi Wang, Zhiyong Zhou, Hongying Li
OBJECTIVE: To evaluate the clinical effectiveness of Onodera prognostic nutrition index (OPNI) in the predictive value of nutrition risk. METHODS: In a prospective cohort study from July 2014 to June 2015 in the Department of General Surgery of the Ninth People's Hospital of Chongqing, NRS2002 and OPNI were conducted in 200 patients undergoing gastrointestinal elective operation. OPNI was calculated with serum albumin (Alb) and peripheral lymphocyte (TLC) [OPNI=Alb(10(9)/L)+5×TLC(10(9)/L)]...
May 2016: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
Katsunobu Sakurai, Tatsuro Tamura, Takahiro Toyokawa, Ryosuke Amano, Naoshi Kubo, Hiroaki Tanaka, Kazuya Muguruma, Masakazu Yashiro, Kiyoshi Maeda, Masaichi Ohira, Kosei Hirakawa
BACKGROUND: Preoperative nutritional status may predict short- and long-term outcomes of patients with cancer. OBJECTIVE: The aim of this study was to clarify the impact of preoperative nutritional status on outcomes of elderly patients who have undergone gastrectomy for gastric cancer (GC). METHODS: A review examining 147 patients treated for GC by gastrectomy at our institution between January 2004 and December 2011 was conducted. Onodera's prognostic nutritional index (PNI) was invoked, using an optimal cutpoint to stratify patients by high (PNI > 43...
October 2016: Annals of Surgical Oncology
Toshifumi Doi, Takeshi Ishikawa, Tetsuya Okayama, Osamu Dohi, Naohisa Yoshida, Kazuhiro Kamada, Kazuhiro Katada, Yoshio Sogame, Kazuhiko Uchiyama, Osamu Handa, Tomohisa Takagi, Hiroaki Yasuda, Junichi Sakagami, Hideyuki Konishi, Yuji Naito, Yoshito Itoh
Nanoparticle albumin-bound paclitaxel(nab-PTX)was approved for the treatment of gastric cancer without a large-scale clinical trial in Japan. Its safety and efficacy should be validated in clinical practice. We retrospectively investigated prognostic factors related to time to treatment failure(TTF)in 11 patients with unresectable or recurrent gastric cancer treated with nab- PTX in our hospital. In univariate analysis, Onodera's prognostic nutritional index(PNI)and the time from the start of first-line chemotherapy to the start of nab-PTX were related to TTF...
February 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Naotsugu Haraguchi, Masataka Ikeda, Masakazu Miyake, Takuya Yamada, Yuko Sakakibara, Eiji Mita, Yuichiro Doki, Masaki Mori, Mitsugu Sekimoto
PURPOSE: To clarify the advantages and disadvantages of stenting as a bridge to surgery (BTS) by comparing the clinical features and outcomes of patients who underwent BTS with those of patients who underwent emergency surgery (ES). METHODS: We assessed technical success, clinical success, surgical procedures, stoma formation, complications, clinicopathological features, and Onodera's prognostic nutritional index (OPNI) in patients who underwent BTS and those who underwent ES...
November 2016: Surgery Today
Chen Jian-Hui, Edward Arthur Iskandar, Sh-Irong Cai, Chuang-Qi Chen, Hui Wu, Jian-Bo Xu, Yu-Long He
The preoperative nutritional and immunological statuses have an important impact in predicting the survival outcome of patients with various types of malignant tumors. Our study aimed to explore the clinical significance and predictive prognostic potential of Onodera's prognostic nutritional index (PNI) in patients with colorectal carcinoma. This retrospective study included a total of 1321 patients who were diagnosed with colorectal cancer and who had been surgically treated between January 1994 and December 2007...
March 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
Katsunobu Sakurai, Masaichi Ohira, Tatsuro Tamura, Takahiro Toyokawa, Ryosuke Amano, Naoshi Kubo, Hiroaki Tanaka, Kazuya Muguruma, Masakazu Yashiro, Kiyoshi Maeda, Kosei Hirakawa
BACKGROUND: Preoperative nutritional status not only correlates with the incidence of postoperative complications but also may be indicative of long-term outcomes for patients with cancer. The impact of preoperative nutritional status on outcomes for patients undergoing gastrectomy for gastric cancer (GC) was investigated. METHODS: The study reviewed 594 patients treated for GC by gastrectomy at the authors' hospital between January, 2004 and December, 2010. Onodera's prognostic nutritional index (PNI) was invoked, using an optimal cut point to group patients as having high (PNI > 45; n = 449) or low (PNI ≤ 45; n = 145) nutritional status...
February 2016: Annals of Surgical Oncology
Keisuke Ihara, Satoru Yamaguchi, Yosuke Shida, Hideo Ogata, Yasushi Domeki, Kentaro Okamoto, Masanobu Nakajima, Kinro Sasaki, Takashi Tsuchioka, Hiroyuki Kato
OBJECTIVE: This study aimed to clarify the relationship between host nutritional status prior to first-line chemotherapy and therapeutic effect, and, whether these nourishment indexes could become factors that predict long-term convalescence in unresectable advanced or recurrent colorectal cancer or not. Summary of Background Date: It has previously been reported that postoperative complications and long-term prognosis of patients with gastrointestinal malignancies may be affected by their nutritional status...
June 17, 2015: International Surgery
S Kusamura, D Baratti, I Hutanu, C Gavazzi, D Morelli, D R Iusco, A Grassi, S Bonomi, S Virzì, E Haeusler, M Deraco
AIMS: Inflammation-based scores such as neutrophil-lymphocyte ratio (NLR) and Onodera nutritional index (ONI) have been identified as new prognosticators in several tumors. We conducted a prognostic analysis of these markers and performed a risk stratification of PMP patients submitted to cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). METHODS: 226 patients from two peritoneal surface malignancies centers participated in this study...
August 2015: European Journal of Surgical Oncology
Takeshi Shimakawa, Shinich Asaka, Masano Sagawa, Asako Shimazaki, Kentaro Yamaguchi, Takebumi Usui, Hajime Yokomizo, Shunichi Shiozawa, Kazuhiko Yoshimatsu, Takao Katsube, Yoshihiko Naritaka
The incidence of postoperative complications and mortality are usually higher in patients with preoperative malnutrition. Malnutrition often preexists, particularly in patients undergoing surgery for esophageal cancer, which is substantially invasive. It is therefore important to understand the nutritional condition of patients and actively control perioperative nutrition.Our hospital has been providing nutritional status screening for patients before resection of esophageal cancer, and we report the current status and evaluation results in this article...
October 2014: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Masano Sagawa, Kazuhiko Yoshimatsu, Hajime Yokomizo, Yuuki Yano, Mao Nakayama, Takefumi Usui, Kentarou Yamaguchi, Shunichi Shiozawa, Takeshi Shimakawa, Takao Katsube, Yoshihiko Naritaka
UNLABELLED: We evaluated the significance of the prognostic nutritional index(PNI)and modified Glasgow Prognostic Score(mGPS)in colorectal cancer resection. METHODS: We classified 165 patients undergoing colorectal cancer excision according to PNI(>40 [n=141]and ≤40[n=24])and mGPS (A/B[n=95], C[n=44], and D [n=26]). We examined the incidence of postoperative complications, postoperative hospital stay, and survival. RESULTS: Both indices were associated with all complications, surgical site infection(SSI), and med ian postoperative hospital stay...
October 2014: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Kiyoshi Maeda, Hisashi Nagahara, Masatsune Shibutani, Hiroshi Otani, Katsunobu Sakurai, Takahiro Toyokawa, Hiroaki Tanaka, Naoshi Kubo, Kazuya Muguruma, Noriko Kamata, Hirokazu Yamagami, Kosei Hirakawa
PURPOSE: The incidence of incisional surgical site infections (SSIs) is reported to be higher among patients with Crohn's disease (CD) than among those with colorectal cancer. It has also been reported that the preoperative nutritional and inflammatory status is associated with the frequency of postoperative complications. Onodera's prognostic nutritional index (OPNI) is a simple and useful parameter for determining the nutritional and inflammatory status. In the present study, we retrospectively investigated the correlation between the OPNI and the incidence of incisional SSI in patients with CD who had undergone bowel resection...
November 2015: Surgery Today
Sebastian L Hofbauer, Allan J Pantuck, Michela de Martino, Ilaria Lucca, Andrea Haitel, Shahrokh F Shariat, Arie S Belldegrun, Tobias Klatte
OBJECTIVE: Accurate postoperative stratification of patients with renal cell carcinoma (RCC) in distinct prognostic groups is essential for tailoring follow-up, medical therapy, and inclusion in clinical trials. Increasing evidence suggests that Onodera׳s prognostic nutritional index (PNI) is a stage- and grade-independent predictor of poor outcomes in patients with cancer, but there are no data in RCC. MATERIALS AND METHODS: We reviewed medical records of 1,344 patients with RCC who underwent radical or partial nephrectomy at the Medical University of Vienna and the University of California-Los Angeles between 1991 and 2012...
February 2015: Urologic Oncology
F Borda, A Borda, J M Zozaya, J Urman, J Jiménez, B Ibáñez
BACKGROUND: Onodera's prognostic nutritional index (OPNI), which is calculated using total lymphocyte count and serum albumin level, has been used as a marker of nutritional status, with its potential prognostic value in colorectal cancer having recently been postulated in Japan and China. There is still no data on the predictive value of OPNI in a Western population. PATIENTS AND METHODS: A consecutive case series of 207 patients scheduled for colorectal cancer resection with curative intent was reviewed...
May 2014: Anales del Sistema Sanitario de Navarra
Tetsuro Ikeya, Masatsune Shibutani, Kiyoshi Maeda, Kenji Sugano, Hisashi Nagahara, Hiroshi Ohtani, Kosei Hirakawa
PURPOSE: Nutrition and immunity significantly affect the progression of cancer in cancer patients. Therefore, the evaluation of the nutritional and immune status would be useful as a prognostic factor and to determine the optimal treatment strategy for patients with unresectable metastatic colorectal cancer who are receiving chemotherapy. The aim of this retrospective study was to evaluate the prognostic significance of the nutritional and immune status in patients with unresectable metastatic colorectal cancer treated with chemotherapy...
February 2015: Journal of Cancer Research and Clinical Oncology
Chengsi Ong, Wee Meng Han, Judith Ju-Ming Wong, Jan Hau Lee
BACKGROUND & AIMS: Malnutrition can significantly affect clinical outcomes in critically ill children. In view of the limitations of anthropometry, nutrition-related serum biomarkers have been used to assess the degree of malnutrition in the pediatric intensive care unit. The aim of this review is to critically appraise the use of nutrition-related serum biomarkers in predicting clinical outcomes in critically ill children. METHODS: We searched major databases (MEDLINE, EMBASE, CINAHL, Cochrane Library) using MeSH terms and key words related to "biomarkers", "nutrition" and "critically ill children"...
April 2014: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Masano Sagawa, Kazuhiko Yoshimatsu, Hajime Yokomizo, Gakuji Osawa, Atsuo Matsumoto, Yuki Yano, Mao Nakayama, Kentarou Yamaguchi, Shunichi Shiozawa, Takeshi Shimakawa, Takao Katsube, Yoshihiko Naritaka
BACKGROUND: We examined the association of the physical, nutritional, and immune status with adverse events in patients treated with mFOLFOX6 adjuvant chemotherapy after colorectal cancer surgery. METHOD: This study included 17 patients, 7 male and 10 female. The median age was 62( range, 32-75) years. The median number of treatment cycles was 12 (range, 4-12). Age, performance status( PS), body mass index( BMI),serum albumin level( Alb),Onodera's prognostic nutritional index( PNI), controlling nutritional status( CONUT),Glasgow prognostic score( GPS),the granulocyte/lymphocyte ratio( G/L),neutrophil count, and the total lymphocyte count( TLC) were evaluated with regard to the nutrition and immunity status of the host before chemotherapy...
November 2013: Gan to Kagaku Ryoho. Cancer & Chemotherapy
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