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https://www.readbyqxmd.com/read/28416426/-the-jard%C3%A3-law-a-real-simplification-of-research-in-france
#1
C Levy, A Rybak, R Cohen, C Jung
The Jardé law was voted in 2012 and its implementing decrees were published in November 2016. The delay between the vote and the decrees highlights the difficulties encountered. This law concerns all research, interventional and otherwise, involving the human person. Each research study must receive the approval of a randomly assigned ethics committee or Committee for the Protection of Persons. The approach here is based on risk in three types of study: interventional studies, studies with minimal risk and intervention, and non-interventional studies (observational studies)...
April 14, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28403263/microneedling-in-all-skin-types-a-review
#2
Lauren Meshkov Bonati, Gorana Kuka Epstein, Tamara Lazic Strugar
<p>INTRODUCTION: Microneedling procedures are growing in popularity for a wide variety of skin conditions. This paper comprehensively reviews the medical literature regarding skin needling efficacy and safety in all skin types and in multiple dermatologic conditions.</p> <p>METHODS: A PubMed literature search was conducted in all languages without restriction and bibliographies of relevant articles reviewed. Search terms included: "microneedling," "percutaneous collagen induction," "needling," "skin needling," and "dermaroller...
April 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28401154/cytotoxicity-and-antimicrobial-activity-of-oral-rinses-in-vitro
#3
Heinz-Dieter Müller, Sigrun Eick, Andreas Moritz, Adrian Lussi, Reinhard Gruber
While oral rinses used for cosmetic purposes only do not necessarily have to be antiseptic, antimicrobial activity is required for medical indications, including oral and periodontal surgery. So the question arises-is the antimicrobial activity of oral rinses associated with any destructive changes in cell viability in vitro? To answer this question, we examined twelve oral rinses with respect to their antimicrobial and cytotoxic activity. Antimicrobial activity was screened against five bacterial strains using disc diffusion...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28398427/disseminated-superficial-actinic-porokeratosis-treated-with-ingenol-mebutate-gel-0-05
#4
Isabella Anderson, Ethan T Routt, Shelbi C Jim On
Disseminated superficial actinic porokeratosis (DSAP) is a chronic condition characterized by numerous atrophic papules and patches with a distinctive peripheral keratotic ridge, typically found on sun-exposed areas. Treatment of DSAP is warranted not only for cosmetic and symptomatic benefits but also to prevent malignant transformation. Successful treatment of DSAP often is difficult and frequently requires the use of multiple modalities. Ingenol mebutate gel 0.05% is a topical medication primarily used for the treatment of actinic keratosis (AK) by inducing cell death...
March 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28397661/-medical-treatment-of-children-with-infantile-haemangiomas
#5
Hanne Kalleklev Velure, Ulla Birgitte Hartling, Anette Schuster, Annette Bygum
Infantile haemangioma is a benign vascular tumour seen in 4-5% of infants. It has a characteristic life cycle comprised by a proliferative phase and a spontaneous involution phase. Most infantile haemangiomas do not require intervention. Treatment is relevant when there is a risk of functional impairment or cosmetic disfigurement, or if the haemangiomas are painful and ulcerating. The beta blocker propranolol has been shown to be an excellent first-line treatment, and we present an algorithm for therapeutic decision and monitoring...
February 20, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28397660/-dermatologic-laser-surgery
#6
Lene Hedelund, Berit C Carlsen, Hans Bredsted Lomholt, Susanne Vissing, Merete Hædersdal
In this article we give an overview of which skin conditions that are currently treated with laser and explains the basic principles of treatment. In addition, we summarize recommendations of the Danish Dermatological Society for demarcation of medical treatments which can be provided free of charge from cosmetic self-payment treatments.
February 20, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28384651/surgical-treatment-of-subungual-squamous-cell-carcinoma-by-wide-excision-of-the-nail-unit-and-skin-graft-reconstruction-an-evaluation-of-treatment-efficiency-and-outcomes
#7
Solène Topin-Ruiz, Catherine Surinach, Stéphane Dalle, Gérard Duru, Brigitte Balme, Luc Thomas
Importance: The best surgical treatment modalities for subungual squamous cell carcinoma (SUSCC) without bone invasion need to be determined. The limited available data on Mohs micrographic surgery do not demonstrate its use as a standard procedure. A previous study in a limited series of patients has shown that wide surgical excision of the nail unit was associated with a low rate of recurrence. Objectives: To confirm the efficiency of wide surgical excision of the nail unit with full-thickness skin graft reconstruction on a series of patients with SUSCC with an extended follow-up and to evaluate short- and long-term postoperative morbidity and patient satisfaction...
April 5, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28379099/frostbite-following-cryolipolysis-treatment-in-a-beauty-salon-a-case-study
#8
W L Choong, H S Wohlgemut, M J Hallam
This case study describes frostbite, a previously unreported complication following cryolipolysis, which resulted in substantial necrosis of the flank. Medical attention was not sought until one week after treatment. On examination, two distinct areas of significant frostbite in the left flank with surrounding erythema were revealed. Surgical intervention was avoided, as is recommended in cases of frostbite, and conservative treatment resulted in recovery of the affected area. Here, the authors highlight the adverse effects related to cryolipolysis, analysing the pathogenesis, clinical manifestations and management of this injury...
April 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28377030/the-role-of-wide-local-excision-for-the-treatment-of-severe-hidradenitis-suppurativa-hurley-grade-iii-retrospective-analysis-of-74-patients
#9
Christian Posch, Babak Monshi, Tamara Quint, Igor Vujic, Nikolaus Lilgenau, Klemens Rappersberger
BACKGROUND: Effective medical treatment for patients with severe hidradenitis suppurativa (HS) is limited. OBJECTIVES: We sought to measure the impact of wide local excision on quality of life in HS Hurley grade III patients and to examine the rate of postoperative complications, disease recurrences, and satisfaction with the cosmetic results. METHODS: Seventy-four patients were enrolled. Outcome measures included Dermatology Life Quality Index responses, disease duration, recurrence, previous therapies, postoperative complications, and satisfaction with cosmetic results...
April 1, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28367216/gc-method-validation-for-the-analysis-of-menthol-in-suppository-pharmaceutical-dosage-form
#10
Murad N Abualhasan, Abdel Naser Zaid, Nidal Jaradat, Ayman Mousa
Menthol is widely used as a fragrance and flavor in the food and cosmetic industries. It is also used in the medical and pharmaceutical fields for its various biological effects. Gas chromatography (GC) is considered to be a sensitive method for the analysis of menthol. GC chromatographic separation was developed using capillary column (VF-624) and a flame ionization detector (FID). The method was validated as per ICH guidelines for various parameters such as precision, linearity, accuracy, solution stability, robustness, limit of detection, and quantification...
2017: International Journal of Analytical Chemistry
https://www.readbyqxmd.com/read/28364525/complications-after-cosmetic-surgery-tourism
#11
Holger J Klein, Dario Simic, Nina Fuchs, Riccardo Schweizer, Tarun Mehra, Pietro Giovanoli, Jan A Plock
Background: Cosmetic surgery tourism characterizes a phenomenon of people traveling abroad for aesthetic surgery treatment. Problems arise when patients return with complications or need of follow-up care. Objectives: To investigate the complications of cosmetic surgery tourism treated at our hospital as well as to analyze arising costs for the health system. Methods: Between 2010 and 2014, we retrospectively included all patients presenting with complications arising from cosmetic surgery abroad...
April 1, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/28363107/do-online-reviews-diminish-physician-authority-the-case-of-cosmetic-surgery-in-the-u-s
#12
Alka V Menon
This article analyzes the substance and perception of online physician reviews, which are qualitative and quantitative assessments of physicians written and shared by patients, in the case of U.S. cosmetic surgery. Like other cash-pay medical specialties, cosmetic surgery is elective and paid for largely out of pocket, with patients having latitude in their choice of surgeon. Drawing on qualitative data from interviews, observations of an American Society of Aesthetic Plastic Surgery professional meeting, and online reviews from the platforms RealSelf and Yelp, I identify two interdependent contributors to physician authority: reputation and expertise...
March 24, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28362477/conditions-of-honey-consumption-in-selected-regions-of-poland
#13
Iwona Kowalczuk, Marzena Jeżewska-Zychowicz, Joanna Trafiałek
BACKGROUND: The nutritional value of honey is a factor that encourages the increase of its consumption. The aim of the study was to identify consumers' behaviours and preferences towards honey and their determinants. METHODS: Quantitative (PAPI method) survey was carried out in 2015 on a sample of 690 respondents from Mazowieckie, Podkarpackie and Zachodniopomorskie voivodeships. The data analyzed were: the frequency of and reasons for honey consumption, preferred buying locations, preferred types of honey, factors considered during purchase and different uses of honey...
January 2017: Acta Scientiarum Polonorum. Technologia Alimentaria
https://www.readbyqxmd.com/read/28361239/implications-of-molecular-diversity-of-chitin-and-its-derivatives
#14
REVIEW
Faez Iqbal Khan, Safikur Rahman, Aarfa Queen, Shahzaib Ahamad, Sher Ali, Jihoe Kim, Md Imtaiyaz Hassan
Chitin is a long unbranched polysaccharide, made up of β-1,4-linked N-acetylglucosamine which forms crystalline fiber-like structure. It is present in the fungal cell walls, insect and crustacean cuticles, nematode eggshells, and protozoa cyst. We provide a critical appraisal on the chemical modifications of chitin and its derivatives in the context of their improved efficacy in medical applications without any side effect. Recent advancement in nanobiotechnology has helped to synthesize several chitin derivatives having significant biological applications...
March 31, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28360965/a-closer-look-at-seborrheic-keratoses-patient-perspectives-clinical-relevance-medical-necessity-and-implications-for-management
#15
James Q Del Rosso
The author sought to discover why seborrheic keratoses that are not symptomatic or clinically suspicious are not considered therapeutically important to most clinicians. The author conducted an office-based, observational study examining how the diagnosis of asymptomatic seborrheic keratoses personally affects patients and what these patients think concerning treatment. Many patients reported being bothered by the diagnosis of seborrheic keratoses, even when told it's not cancerous, and indicated an interest in its treatment...
March 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28356439/botulinum-neurotoxins-biology-pharmacology-and-toxicology
#16
REVIEW
Marco Pirazzini, Ornella Rossetto, Roberto Eleopra, Cesare Montecucco
The study of botulinum neurotoxins (BoNT) is rapidly progressing in many aspects. Novel BoNTs are being discovered owing to next generation sequencing, but their biologic and pharmacological properties remain largely unknown. The molecular structure of the large protein complexes that the toxin forms with accessory proteins, which are included in some BoNT type A1 and B1 pharmacological preparations, have been determined. By far the largest effort has been dedicated to the testing and validation of BoNTs as therapeutic agents in an ever increasing number of applications, including pain therapy...
April 2017: Pharmacological Reviews
https://www.readbyqxmd.com/read/28353001/de-novo-biosynthesis-of-trans-cinnamic-acid-derivatives-in-saccharomyces-cerevisiae
#17
Manuela Gottardi, Jan Dines Knudsen, Lydie Prado, Mislav Oreb, Paola Branduardi, Eckhard Boles
The production of natural aroma compounds is an expanding field within the branch of white biotechnology. Three aromatic compounds of interest are cinnamaldehyde, the typical cinnamon aroma that has applications in agriculture and medical sciences, as well as cinnamyl alcohol and hydrocinnamyl alcohol, which have applications in the cosmetic industry. Current production methods, which rely on extraction from plant materials or chemical synthesis, are associated with drawbacks regarding scalability, production time, and environmental impact...
March 29, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28349651/dermasence-refining-gel-modulates-pathogenetic-factors-of-rosacea-in-vitro
#18
C Borelli, B Becker, S Thude, B Fehrenbacher, D Isermann
BACKGROUND: Over the counter cosmetics sold for local treatment of slight to moderate rosacea often state the claim of actively modulating rosacea pathogenesis. Factors involved in the pathogenesis of this common yet complex skin disorder include kallikrein-related peptidase 5 (KLK5), LL-37, as well as protease-activated receptor 2 (PAR2) and vascular endothelial growth factor (VEGF). OBJECTIVE: The objective was to prove the modulating effect of the cosmetic skin care agent Dermasence Refining Gel (DRG) on factors involved in rosacea pathogenesis...
March 27, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28343243/fusarium-species-a-promising-tool-box-for-industrial-biotechnology
#19
REVIEW
Marina Gabriel Pessôa, Bruno Nicolau Paulino, Mario Cezar Rodrigues Mano, Iramaia Angélica Neri-Numa, Gustavo Molina, Glaucia Maria Pastore
Global demand for biotechnological products has increased steadily over the years. Thus, need for optimized processes and reduced costs appear as a key factor in the success of this market. A process tool of high importance is the direct or indirect use of enzymes to catalyze the generation of various substances. Also, obtaining aromas and pigments from natural sources has becoming priority in cosmetic and food industries in order to supply the demand from consumers to substitute synthetic compounds, especially when by-products can be used as starting material for this purpose...
March 25, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28339500/detecting-congenital-malformations-lessons-learned-from-the-mpepu-study-botswana
#20
Gbolahan Ajibola, Rebecca Zash, Roger L Shapiro, Oganne Batlang, Kerapetse Botebele, Kara Bennett, Florence Chilisa, Erik von Widenfelt, Joseph Makhema, Shahin Lockman, Lewis B Holmes, Kathleen M Powis
INTRODUCTION: A large and increasing number of HIV-infected women are conceiving on antiretroviral treatment (ART). While most antiretrovirals are considered safe in pregnancy, monitoring for rare pregnancy and infant adverse outcomes is warranted. METHODS: We conducted a retrospective secondary analysis nested within a clinical trial of infant cotrimoxazole vs. placebo prophylaxis in Botswana (the Mpepu Study). Infants were examined at birth, and at least every 3 months through 18 months of age...
2017: PloS One
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