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https://www.readbyqxmd.com/read/27913785/safety-assessment-of-alumina-and-aluminum-hydroxide-as-used-in-cosmetics
#1
Lillian C Becker, Ivan Boyer, Wilma F Bergfeld, Donald V Belsito, Ronald A Hill, Curtis D Klaassen, Daniel C Liebler, James G Marks, Ronald C Shank, Thomas J Slaga, Paul W Snyder, F Alan Andersen
This is a safety assessment of alumina and aluminum hydroxide as used in cosmetics. Alumina functions as an abrasive, absorbent, anticaking agent, bulking agent, and opacifying agent. Aluminum hydroxide functions as a buffering agent, corrosion inhibitor, and pH adjuster. The Food and Drug Administration (FDA) evaluated the safe use of alumina in several medical devices and aluminum hydroxide in over-the-counter drugs, which included a review of human and animal safety data. The Cosmetic Ingredient Review (CIR) Expert Panel considered the FDA evaluations as part of the basis for determining the safety of these ingredients as used in cosmetics...
November 2016: International Journal of Toxicology
https://www.readbyqxmd.com/read/27903280/a-critical-review-of-the-current-knowledge-regarding-the-biological-impact-of-nanocellulose
#2
REVIEW
C Endes, S Camarero-Espinosa, S Mueller, E J Foster, A Petri-Fink, B Rothen-Rutishauser, C Weder, M J D Clift
Several forms of nanocellulose, notably cellulose nanocrystals and nanofibrillated cellulose, exhibit attractive property matrices and are potentially useful for a large number of industrial applications. These include the paper and cardboard industry, use as reinforcing filler in polymer composites, basis for low-density foams, additive in adhesives and paints, as well as a wide variety of food, hygiene, cosmetic, and medical products. Although the commercial exploitation of nanocellulose has already commenced, little is known as to the potential biological impact of nanocellulose, particularly in its raw form...
December 1, 2016: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/27900664/improvement-production-of-hyaluronic-acid-by-streptococcus-zooepidemicus-in-sugarcane-molasses
#3
Nicole Caldas Pan, Hanny Cristina Braga Pereira, Maria de Lourdes Corradi da Silva, Ana Flora Dalberto Vasconcelos, Maria Antonia Pedrine Colabone Celligoi
Microbial hyaluronic acid (HA) production has been preferred rather than extraction from animal tissue for medical and cosmetic applications. In this context, to obtain an economically competitive HA production by Streptococcus zooepidemicus, culture conditions were studied to improve the polymer production in sugarcane molasses. The highest HA production by S. zooepidemicus ATCC 39920 achieved was 2.825 g. L(-1) in a 4.5 L bioreactor with controlled pH (8.0) and medium containing molasses (85.35 g.L(-1) total sugar) pretreated with activated charcoal and yeast extract (50 g...
November 30, 2016: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/27882506/cosmetics-use-related-adverse-events-and-determinants-among-jigjiga-town-residents-eastern-ethiopia
#4
Arebu I Bilal, Zelalem Tilahun, Ebrahim D Osman, Anwar Mulugeta, Muktar Shekabdulahi, Derbew Fikadu Berhe
INTRODUCTION: Non-medicated cosmetics use is very common among the Ethiopian population. However, little is known about these products' related adverse events. The aim of this study was to assess the prevalence and determinants of cosmetics-related adverse events among Jigjiga Town residents, Eastern Ethiopia. METHODS: A community-based cross-sectional study design was conducted in May and June 2014. Semi-structured interviews were used to collect cosmetics use pattern and related adverse events...
November 23, 2016: Dermatology and Therapy
https://www.readbyqxmd.com/read/27882312/supernumerary-nostril-a-case-report
#5
Bo-Eun Choi, Seung-O Ko, Hyo-Keun Shin
BACKGROUND: Supernumerary nostril is a congenital anomaly that contains additional nostril with or without accessory cartilage. These rare congenital nasal deformities result from embryological defects. Since 1906, Lindsay (Trans Pathol Soc Lond. 57:329-330, 1906) has published the first research of bilateral supernumerary nostrils, and only 34 cases have been reported so far in the English literature. CASE PRESENTATION: A 1-year-old female baby was brought to our department group for the treatment of an accessory opening above the left nostril which had been presented since her birth...
December 2016: Maxillofacial Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27879084/topical-preparations-and-their-use-in-dermatology
#6
Johannes Wohlrab
The challenges of everyday clinical routine require dermatologists to have a basic knowledge of the composition of topical preparations as well as the regulatory background associated with their prescription. Proper selection, prescription, and application of topical preparations, depending on the respective indication, are key to professional and responsible medical practice. Problems commonly arise with respect to regulatory classifications (medicinal products, medical devices, or cosmetics), eligibility for reimbursement by the statutory health insurances (GKV), and insufficient declaration of vehicle systems...
November 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/27873347/infantile-hemangioma-with-minimal-or-arrested-growth-further-observations-on-clinical-and-histopathologic-findings-of-this-unique-but-underrecognized-entity
#7
Ellen Hui Ma, Susan J Robertson, Chung W Chow, Philip S Bekhor
BACKGROUND: Infantile hemangioma (IH) with minimal or arrested growth (IH-MAG) is becoming increasingly recognized in the literature. It is important to be aware of their existence, because the correct diagnosis is essential for prognostication and treatment and, in the case of facial segmental lesions, the direction of further investigations if PHACE (posterior fossa abnormalities and other structural brain abnormalities; hemangioma(s) of the cervical facial region; arterial cerebrovascular anomalies; cardiac defects, aortic coarctation, and other aortic abnormalities; eye anomalies) syndrome or Sturge-Weber syndrome is suspected...
November 22, 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27872935/the-social-transformation-of-singapore-medicine-through-55-years-of-the-smj
#8
Ee Heok Kua, Jade Phek Hui Kua
The Singapore Medical Journal (SMJ) has in the past 55 years reflected the phenomenal socioeconomic progress of Singapore. Publications in the pre-independent years were mainly on diseases like cholera, diphtheria, leprosy, tetanus and worm infestation. In the new millennium, the research papers included molecular genetics, health economics, obesity, Internet medicine, cancer, cosmetic surgery and palliative medicine. The annual SMA Lecture published in the SMJ provides an ethical compass for doctors to remind them of primum non nocere...
November 2016: Singapore Medical Journal
https://www.readbyqxmd.com/read/27870932/investigation-of-the-toxicity-of-bismuth-oxide-nanoparticles-in-various-cell-lines
#9
Mahmoud Abudayyak, Ezgi Öztaş, Merve Arici, Gül Özhan
Nanoparticles have been drawn attention in various fields ranging from medicine to industry because of their physicochemical properties and functions, which lead to extensive human exposure to nanoparticles. Bismuth (Bi)-based compounds have been commonly used in the industrial, cosmetic and medical applications. Although the toxicity of Bi-based compounds was studied for years, there is a serious lack of information concerning their toxicity and effects in the nanoscale on human health and environment. Therefore, we aimed to investigate the toxic effects of Bi (III) oxide (Bi2O3) nanoparticles in liver (HepG2 hepatocarcinoma cell), kidney (NRK-52E kidney epithelial cell), intestine (Caco-2 colorectal adenocarcinoma cell), and lung (A549 lung carcinoma cell) cell cultures...
November 18, 2016: Chemosphere
https://www.readbyqxmd.com/read/27870777/minocycline-induced-scleral-and-dermal-hyperpigmentation
#10
Cheryl Haskes, Michael Shea, David Imondi
PURPOSE: To present a case of minocycline-induced blue scleral pigmentation and discuss the pathophysiology and differential diagnoses. The uses, mechanisms, and other adverse effects of minocycline will also be highlighted. CASE REPORT: An elderly Caucasian male patient presented for routine ocular examination complaining of blue discoloration to the whites of his eyes. He was found to have bilateral blue scleral pigmentation and blue discoloration to various other dermal areas of his body...
November 18, 2016: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/27866379/effects-of-oral-exposure-to-the-phthalate-substitute-acetyl-tributyl-citrate-on-female-reproduction-in-mice
#11
Lindsay M Rasmussen, Nivedita Sen, Xiaosong Liu, Zelieann R Craig
Acetyl tributyl citrate (ATBC), is a phthalate substitute used in food and medical plastics, cosmetics and toys. Although systemically safe up to 1000 mg kg(-1)  day(-1) , its ability to cause reproductive toxicity in females at levels below 50 mg kg(-1)  day(-1) has not been examined. This study evaluated the effects of lower ATBC exposures on female reproduction using mice. Adult CD-1 females (n = 7-8 per treatment) were dosed orally with tocopherol-stripped corn oil (vehicle), 5 or 10 mg kg(-1)  day(-1) ATBC daily for 15 days, and then bred with a proven breeder male...
November 20, 2016: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/27859716/response-to-the-concept-of-fragile-skin-a-case-of-disease-mongering-in-dermatology
#12
Ulrike Blume-Peytavi
We thank Dr Elsner for his interest in our supplement "Fragility of epidermis in newborns, children and adolescents" recently published in this journal, but note his concern about the value of the term "fragile skin" as a scientifically useful disease definition, given the wide spectrum of conditions covered by the term [1]. Contrary to what is suggested in the letter by Dr Elsner, fragile skin is not a "disease" and should not be confounded with skin fragility existing in the repertoire of dermatological diseases requiring medical treatment using pharmaceutical interventions (e...
November 11, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27856773/real-world-efficacy-of-1064-nm-nd-yag-laser-for-the-treatment-of-onychomycosis
#13
REVIEW
Jason K Rivers, Brianne J Vestvik, Jonathan Berkowitz
BACKGROUND: Onychomycosis is a cosmetic and, at times, medical concern; therefore, effective and safe alternatives to treatment are needed. OBJECTIVE: To determine the efficacy of a 1064-nm Nd:YAG laser for the treatment of onychomycosis in a real-world setting. METHODS: A single-centre retrospective chart review was conducted between 2012 and 2013. One hundred consecutive patients with a culture- and/or potassium hydroxide-confirmed diagnosis of onychomycosis were treated at least twice...
November 16, 2016: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/27853683/medical-ethics-in-plastic-surgery-a-mini-review
#14
REVIEW
Nasrin Nejadsarvari, Ali Ebrahimi, Azin Ebrahimi, Haleh Hashem-Zade
Currently, cosmetic surgery is spread around the world. Several factors are involved in this rapidly evolving field such as socio-economic development, changes in cultural norms, globalization and the effects of Western culture, advertising, media, and mental disorders. Nowadays the cosmetic surgery is becoming a profitable business, which deals exclusively with human appearance and less from the perspective of beauty based on physical protests and considering factors such as sex, age, and race. The morality of plastic surgery subspecialty has undergone many moral dilemmas in the past few years...
September 2016: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/27852988/clinical-characteristics-of-acquired-ungual-fibrokeratoma
#15
Sewon Hwang, Miri Kim, Baik Kee Cho, Hyun Jeong Park
BACKGROUND: Acquired ungual fibrokeratomas are uncommon fibrous tissue tumors located in the ungual area. Though there are many reports of this entity, only some reports have reviewed the clinical features of the tumor. AIMS: The aim of this study was to clarify the clinical characteristics of acquired ungual fibrokeratomas. METHODS: We reviewed twenty patients who were treated surgically at our clinic from 2003 to 2014 for acquired ungual fibrokeratomas confirmed on histopathological examination...
November 11, 2016: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/27852689/female-exposure-to-phthalates-and-time-to-pregnancy-a-first-pregnancy-planner-study
#16
Anne Marie L Thomsen, Anders H Riis, Jørn Olsen, Bo A G Jönsson, Christian H Lindh, Niels H Hjollund, Tina Kold Jensen, Jens Peter Bonde, Gunnar Toft
STUDY QUESTION: Is female exposure to phthalate metabolites associated with reduced fecundity, as estimated by prolonged time to pregnancy (TTP)? SUMMARY ANSWER: Female exposure to monoethyl phthalate (MEP) but not monobutyl phthalate (MBP), monobenzyl phthalate (MBzP) and monoethylhexyl phthalate (MEHP) was associated with a longer TTP. WHAT IS KNOWN ALREADY: Male exposure to phthalates is potentially associated with adverse effects on human fecundity in epidemiological studies, but little is known about the potential effects on female reproduction...
November 16, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27848197/12-month-efficacy-of-a-single-radiofrequency-ablation-on-autonomously-functioning-thyroid-nodules
#17
Stella Bernardi, Fulvio Stacul, Andrea Michelli, Fabiola Giudici, Giulia Zuolo, Nicolò de Manzini, Chiara Dobrinja, Fabrizio Zanconati, Bruno Fabris
PURPOSE: Radiofrequency ablation has been advocated as an alternative to radioiodine and/or surgery for the treatment of autonomously functioning benign thyroid nodules. However, only a few studies have measured radiofrequency ablation efficacy on autonomously functioning benign thyroid nodules. The aim of this work was to evaluate the 12-month efficacy of a single session of radiofrequency ablation (performed with the moving shot technique) on solitary autonomously functioning benign thyroid nodules...
November 15, 2016: Endocrine
https://www.readbyqxmd.com/read/27846016/botanicals-in-dermatology-essential-oils-botanical-allergens-and-current-regulatory-practices
#18
Sarah Mortimer, Margo Reeder
Largely because of their perceived safety, the use of essential oils and other botanically derived products has become increasingly popular. Recent evidence raises concern about the safety of these products, frequently found in cosmetics and sought as an alternative to standard medical treatments. Essential oils are challenging to standardize because of the variable growing conditions, genetics, and harvesting of botanicals. There exists a potential for adverse reactions, in particular allergic contact dermatitis...
November 2016: Dermatitis
https://www.readbyqxmd.com/read/27842934/surface-properties-and-morphology-of-mixed-poss-dppc-monolayers-at-the-air-water-interface
#19
Monika Rojewska, Marta Skrzypiec, Krystyna Prochaska
From the point of view of the possible medical applications of POSS (polyhedral oligomeric silsesquioxanes), it is crucial to analyse interactions occurring between POSS and model biological membrane at molecular level. Knowledge of the interaction between POSS and DPPC (1,2-dipalmitoyl-sn-glycero-3-phosphocholine) allows prediction of the impact of POSS contained in biomaterials or cosmetics on a living organism. In the study presented, the surface properties and morphology of Langmuir monolayers formed by mixtures of POSS and the phospholipid (DPPC) at the air/water surface are examined...
October 29, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27837313/cosmetic-lengthening-what-are-the-limits
#20
F Guerreschi, H Tsibidakis
OBJECTIVES: In the last decades, limb lengthening has not been limited to the treatment of patients with dwarfism and deformities resulting from congenital anomalies, trauma, tumor and infections, but, has also been used for aesthetic reasons. Cosmetic lengthening by the Ilizarov method with circular external fixation has been applied to individuals with constitutional short stature who wish to be taller. MATERIALS AND METHODS: From January 1985 to December 2010, the medical records of 63 patients with constitutional short stature (36 M, 27F; 126 legs) who underwent cosmetic bilateral leg lengthening using a hybrid advanced fixator according to the Ilizarov method, were reviewed, retrospectively...
November 11, 2016: Journal of Children's Orthopaedics
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