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Prognostic Nutritional Index

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https://www.readbyqxmd.com/read/29150094/-geriatric-assessment-and-prognostic-scores-in-older-cancer-patient-additional-support-to-the-therapeutic-decision
#1
REVIEW
Frédéric Pamoukdjian, Evelyne Liuu, Philippe Caillet, Mathilde Gisselbrecht, Stéphane Herbaud, Pascaline Boudou-Rouquette, Laurent Zelek, Elena Paillaud
Cancer is a disease of the elderly as demonstrated by the epidemiological evolution of Western countries. Indeed, two third of cancers newly diagnosed occur over 65 years. However, older cancer patients have been often excluded from clinical trials in oncology and the extrapolation of cancer treatments in this population remains difficult in practice. Scientific societies recommend that a comprehensive geriatric assessment (CGA) be performed in patients aged 70 and over and selected using screening tools for frailty such as the G8 index...
November 14, 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/29142183/worse-preoperative-status-based-on-inflammation-and-host-immunity-is-a-risk-factor-for-surgical-site-infections-in-colorectal-cancer-surgery
#2
Masano Sagawa, Kazuhiko Yoshimatsu, Hajime Yokomizo, Yuki Yano, Sachiyo Okayama, Takebumi Usui, Kentaro Yamaguchi, Shunichi Shiozawa, Takeshi Shimakawa, Takao Katsube, Hiroyuki Kato, Yoshihiko Naritaka
OBJECTIVE: The modified Glasgow Prognostic Score (mGPS) is an inflammation-based measure of malnutrition that reflects a state of cachexia in cancer patients. We evaluated mGPS as an index to predict surgical site infection (SSI) incidence in patients undergoing colorectal cancer surgery. SUBJECTS AND METHODS: We retrospectively analyzed 351 patients who underwent colon cancer resection. Factors correlated with the incidence of SSIs were identified by logistic analysis and stepwise selection...
2017: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/29137377/an-evaluation-of-nutrition-intervention-during-radiation-therapy-in-patients-with-locoregionally-advanced-nasopharyngeal-carcinoma
#3
Ting Jin, Kai-Xin Li, Pei-Jing Li, Shuang Huang, Xiao-Zhong Chen, Ming Chen, Qiao-Ying Hu, Lei Shi, Yuan-Yuan Chen
Purpose: To evaluate the effectiveness of nutrition intervention during radiation for patients with locoregionally advanced (III-IVa) nasopharyngeal carcinoma (NPC). Materials and Methods: We retrospectively reviewed 117 patients with locoregionally advanced (III-IVa) NPC treated between December 2015 and March 2016 in Zhejiang Cancer Hospital. All the patients underwent radical chemo-radiotherapy. First, all the patients were divided into the nutrition intervention group and the control group, depending on whether they accepted nutrition intervention...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29137238/significance-of-nlda-the-commixed-index-of-inflammation-immune-responses-hemostasis-and-nutrition-for-predicting-metastatic-non-small-cell-lung-cancer-prognosis-and-metastases
#4
Wen-Wen Sun, Jia-An Hu, Wen-Quan Niu, Bei-Li Gao, Zhi-Hong Xu
Purpose: This study aimed to take a comprehensive review of the hematological indexes and discover a novel, comprehensive, and economical index for prognostic prediction. Results: The predictive prognostic model revealed that an elevated value of NLDA (NLDA = neutrophil count/lymphocyte count × D-dimer count/albumin) was an independent risk factor for one-year adverse prognosis (hazard ratio = 3.038; 95% confidence interval [CI], 1.959-4.712; P < 0.001). The C-indexes of internal and external validation in nomogram were 0...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29126400/the-preoperative-neutrophil-to-lymphocyte-ratio-is-a-superior-indicator-of-prognosis-compared-with-other-inflammatory-biomarkers-in-resectable-colorectal-cancer
#5
Yongxi Song, Yuchong Yang, Peng Gao, Xiaowan Chen, Dehao Yu, Yingying Xu, Junhua Zhao, Zhenning Wang
BACKGROUND: Growing evidence has indicated that some inflammatory markers, including lymphocyte to monocyte ratio (LMR), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and prognostic nutritional index (PNI), can be used as indicators in the prognosis of colorectal cancer (CRC). However, there is controversy concerning what is the best predictor of prognosis in CRC. METHODS: A cohort of 1744 CRC patients in our institution was analyzed retrospectively...
November 10, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29113668/preoperative-geriatric-nutritional-risk-index-a-predictive-and-prognostic-factor-in-patients-with-pathological-stage-i-non-small-cell-lung-cancer
#6
Fumihiro Shoji, Taichi Matsubara, Yuka Kozuma, Naoki Haratake, Takaki Akamine, Shinkichi Takamori, Masakazu Katsura, Gouji Toyokawa, Tatsuro Okamoto, Yoshihiko Maehara
BACKGROUND: Surgical outcomes of early-stage non-small cell lung cancer (NSCLC) are poor. The Geriatric Nutritional Risk Index (GNRI) is a useful parameter for evaluating nutritional status. We aimed to investigate if preoperative GNRI could be a predictive factor for pathological stage I NSCLC patients. PATIENTS AND METHODS: We retrospectively selected 141 consecutive pathological stage I NSCLC patients treated from August 2005 to August 2010. We analyzed their preoperative GNRI in univariate and multivariate Cox regression analyses for postoperative recurrence-free survival (RFS)...
December 2017: Surgical Oncology
https://www.readbyqxmd.com/read/29112563/naples-prognostic-score-based-on-nutritional-and-inflammatory-status-is-an-independent-predictor-of-long-term-outcome-in-patients-undergoing-surgery-for-colorectal-cancer
#7
Gennaro Galizia, Eva Lieto, Annamaria Auricchio, Francesca Cardella, Andrea Mabilia, Vlasta Podzemny, Paolo Castellano, Michele Orditura, Vincenzo Napolitano
BACKGROUND: The existing scores reflecting the patient's nutritional and inflammatory status do not include all biomarkers and have been poorly studied in colorectal cancers. OBJECTIVE: The purpose of this study was to assess a new prognostic tool, the Naples prognostic score, comparing it with the prognostic nutritional index, controlling nutritional status score, and systemic inflammation score. DESIGN: This was an analysis of patients undergoing surgery for colorectal cancer...
December 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29100345/glasgow-prognostic-score-is-superior-to-other-inflammation-based-scores-in-predicting-survival-of-diffuse-large-b-cell-lymphoma
#8
Xiaoxiao Hao, Yongqiang Wei, Xiaolei Wei, Lizhi Zhou, Qi Wei, Yuankun Zhang, Weimin Huang, Ru Feng
Inflammation-based prognostic scores, such as the glasgow prognostic score (GPS), prognostic index (PI), prognostic nutritional index (PNI), neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) were related to survival in many solid tumors. Recent study showed that GPS can be used to predict outcome in diffuse large B-cell lymphoma (DLBCL). However, other inflammation related scores had not been reported and it also remained unknown which of them was the most useful to evaluate the survival in DLBCLs...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29099300/diagnostic-value-of-preoperative-inflammatory-markers-in-patients-with-glioma-a-multicenter-cohort-study
#9
Shi-Hao Zheng, Jin-Lan Huang, Ming Chen, Bing-Long Wang, Qi-Shui Ou, Sheng-Yue Huang
OBJECTIVE Glioma is the most common form of brain tumor and has high lethality. The authors of this study aimed to elucidate the efficiency of preoperative inflammatory markers, including neutrophil/lymphocyte ratio (NLR), derived NLR (dNLR), platelet/lymphocyte ratio (PLR), lymphocyte/monocyte ratio (LMR), and prognostic nutritional index (PNI), and their paired combinations as tools for the preoperative diagnosis of glioma, with particular interest in its most aggressive form, glioblastoma (GBM). METHODS The medical records of patients newly diagnosed with glioma, acoustic neuroma, meningioma, or nonlesional epilepsy at 3 hospitals between January 2011 and February 2016 were collected and retrospectively analyzed...
November 3, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29089030/systemic-immune-inflammation-index-predicting-chemoradiation-resistance-and-poor-outcome-in-patients-with-stage-iii-non-small-cell-lung-cancer
#10
Yu-Suo Tong, Juan Tan, Xi-Lei Zhou, Ya-Qi Song, Ying-Jian Song
BACKGROUND: There is increasing evidence that the existence of systemic inflammation response is correlated with poor prognosis in several solid tumors. The aim of this retrospective study was to investigate the association between systemic immune-inflammation index (SII) and therapy response and overall survival in patients with stage III non-small cell lung cancer (NSCLC). The prognostic values of neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and prognostic nutritional index (PNI) were also evaluated...
October 31, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29083236/clinical-value-of-nutritional-status-in-cancer-what-is-its-impact-and-how-it-affects-disease-progression-and-prognosis
#11
Maria Mantzorou, Antonios Koutelidakis, Stamatios Theocharis, Constantinos Giaginis
Malnutrition is a common finding in cancer patients, which can affect disease progression and survival. This review aims to critically summarize the prognostic role of nutritional status, from Body Mass Index (BMI) and weight loss to nutrition screening tools and biochemical indices, in cancer patients. According to the currently available data, Prognostic Nutritional Index (PNI) was a significant prognostic factor of patients' survival, both in univariate and multivariate analyses. Pre-operative albumin was also correlated with worse outcomes, being an independent prognostic factor of survival in several studies...
October 30, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/29066730/neutrophil-lymphocyte-ratio-plus-prognostic-nutritional-index-predicts-the-outcomes-of-patients-with-unresectable-hepatocellular-carcinoma-after-transarterial-chemoembolization
#12
Chang Liu, Lei Li, Wu-Sheng Lu, Hua Du, Lu-Nan Yan, Jia-Yin Yang, Tian-Fu Wen, Guo-Jun Zeng, Li Jiang, Jian Yang
For many malignancies, inflammation-based scores correlate with survival. The neutrophil-to-lymphocyte ratio (NLR) and prognostic nutritional index (PNI) are immunonutritional indices associated with postoperative outcomes in patients with hepatocellular carcinoma (HCC). We evaluated whether a combined preoperative NLR and PNI score was prognostically superior to either index alone in 793 patients with unresectable HCC after transarterial chemoembolization. Patient demographic, clinical, and pathological data were also collected and analysed...
October 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29066691/-a-prognostic-factor-based-on-inflammation-nutrition-and-immune-status-for-fstage-ii-iii-colorectal-cancer
#13
Kazuhiko Yoshimatsu, Masano Sagawa, Hajime Yokomizo, Yuki Yano, Sachiyo Okayama, Masaya Satake, Atsuo Matsumoto, Yasufumi Yamada, Shinichi Asaka, Takebumi Usui, Kentaro Yamaguchi, Shunichi Shiozawa, Takeshi Shimakawa, Takao Katsube, Yoshihiko Naritaka
INTRODUCTION: We investigated whether the prognostic nutritional index(PNI), controlling nutritional status(CONUT), modified Glasgow prognostic score(mGPS), and the neutrophil count/lymphocyte number ratio(NLR)could be prognostic factors for fStage II/III colorectal cancer. SUBJECTS AND METHODS: The subjects were 115 patients with fStage II/III colorectal cancer who underwent curative resection. We studied the relationship with 3-year disease-free survival(DFS)and 5-year survival rate(OS)...
October 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29066690/-preoperative-prognostic-nutrition-index-is-a-predictive-factor-of-complications-in-laparoscopic-colorectal-surgery
#14
Yuki Yano, Masano Sagawa, Hajime Yokomizo, Sachiyo Okayama, Yasufumi Yamada, Takebumi Usui, Kentaro Yamaguchi, Shunichi Shiozawa, Kazuhiko Yoshimatsu, Takeshi Shimakawa, Takao Katsube, Hiroyuki Kato, Yoshihiko Naritaka
Paitients and methods: We retrospectively reviewed a database of 188 patients who underwent resection for colorectal cancer with laparoscopic surgery between July 2007 and March 2015. The prognostic nutrition index(PNI), modified Glas- gow prognostic score(mGPS), controlling nutritional status(CONUT), and neutrophil/lymphocyte ratio(N/L)were measured in these patients. We examined the association between postoperative complications and clinicopathological factors. RESULTS: The study included 110 men and 78 women...
October 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29066689/-analysis-of-patients-who-received-enteral-nutrition-in-the-course-of-chemotherapy
#15
Junji Kawada, Masaya Nishino, Tomoki Hata, Takayuki Ogino, Hiromitsu Hoshino, Miho Okano, Kenichi Nagai, Yongkook Kim, Masaki Okuyama, Toshimasa Tsujinaka
BACKGROUND: Chemotherapy-related adverse events can deteriorate the quality of life, as well as chemotherapy tolerance, for patients with gastric cancer. Nutritional support may prevent chemotherapy-related adverse events. METHODS: Five patients who received chemotherapy for advanced gastric cancer were prescribed enteral nutrition(Elental®or ENEVO®). We retrospectively evaluated the efficacy and safety of chemotherapy while receiving enteral nutrition. RESULTS: All patients consumed more than one bottle of enteral nutrition during chemotherapy...
October 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29055624/geriatric-assessment-and-biomarkers-in-patients-with-metastatic-breast-cancer-receiving-first-line-mono-chemotherapy-results-from-the-randomized-phase-iii-pelican-trial
#16
Friedemann Honecker, Nadia Harbeck, Claudia Schnabel, Ulrich Wedding, Dirk Waldenmaier, Steffen Saupe, Elke Jäger, Marcus Schmidt, Rolf Kreienberg, Lothar Müller, Burkhard Otremba, Julia Dorn, Mathias Warm, Salah-Eddin Al-Batran, Maike de Wit
OBJECTIVES: To determine predictive/prognostic factors for patients with metastatic breast cancer (MBC) receiving first-line monochemotherapy using biomarker analysis and geriatric assessment (GA). MATERIALS AND METHODS: Karnofsky Performance Status (KPS) and GA as clinical parameters, and prognostic inflammatory and nutritional index (PINI), and Glasgow prognostic score (GPS) as biomarkers were analyzed for association with clinical outcome within the randomized phase III PEg-LIposomal Doxorubicin vs...
October 18, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29049803/prognostic-significance-of-immune-nutritional-parameters-for-surgically-resected-elderly-lung-cancer-patients-a-multicentre-retrospective-study
#17
Fumihiro Shoji, Naoko Miura, Taichi Matsubara, Takaki Akamine, Yuka Kozuma, Naoki Haratake, Shinkichi Takamori, Masakazu Katsura, Kazuki Takada, Gouji Toyokawa, Tomoyoshi Takenaka, Koji Yamazaki, Tatsuro Okamoto, Sadanori Takeo, Yoshihiko Maehara
OBJECTIVES: The world's population is rapidly ageing, and the age of patients with lung cancer will increase as well. The prognostic nutritional index, controlling nutritional status and the geriatric nutritional risk index (GNRI) are useful parameters for evaluating immune-nutritional status. We aimed to perform a multicentre retrospective study to investigate the correlations of these immune-nutritional parameters with postoperative comorbidities or surgical outcomes of elderly patients with non-small-cell lung cancer (NSCLC)...
October 16, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29033591/clinicopathological-features-and-prognoses-in-younger-and-older-patients-with-gastric-cancer
#18
Shubin Song, Chunfeng Li, Sen Li, Xiliang Cong, Yingwei Xue
BACKGROUND AND OBJECTIVES: Patients of different ages with gastric cancer (GC) have different clinicopathological features and prognoses. The results for different crowds are limited and controversial. The aim of this study was to investigate the differences in clinicopathological features and prognoses between younger and older GC patients. METHODS: From January 2007 to December 2011, a consecutive total of 112 GC patients under 41 years old and 358 GC patients over 69 years old who underwent gastrectomy for GC were recruited for this study...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29029780/risk-factors-for-surgical-site-infection-after-stoma-closure-comparison-between-pursestring-wound-closure-and-conventional-linear-wound-closure-propensity-score-matching-analysis
#19
Masashi Yamamoto, Keitaro Tanaka, Shinsuke Masubuchi, Masatsugu Ishii, Hiroki Hamamoto, Shigenori Suzuki, Yasuhiko Ueda, Junji Okuda, Kazuhisa Uchiyama
PURPOSE: Stoma closure has been associated with a high rate of surgical site infection (SSI) and the optimal skin closure method is still controversial. The aim of this study was to compare the short-term and long-term outcomes between the conventional linear closure (CC) and the persestring closure (PC) using propensity score matching analysis. METHODS: We analysed the data of 360 patients who underwent stoma closure with CC or PC between January 2000 and December 2014...
October 6, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/29027629/combined-analysis-of-the-preoperative-and-postoperative-prognostic-nutritional-index-offers-a-precise-predictor-of-the-prognosis-of-patients-with-gastric-cancer
#20
Yuki Murakami, Hiroaki Saito, Yusuke Kono, Yuji Shishido, Hirohiko Kuroda, Tomoyuki Matsunaga, Yoji Fukumoto, Tomohiro Osaki, Keigo Ashida, Yoshiyuki Fujiwara
PURPOSE: The prognostic nutritional index (PNI) is considered useful for predicting the prognosis of patients with gastric cancer (GC). This retrospective study investigated the relationship between both the pre- and postoperative PNI and the prognosis of GC patients. METHODS: The subjects of this study were 254 patients who underwent curative surgery for histopathologically diagnosed GC. RESULTS: Patients were divided according to their pre- and postoperative PNI as follows: preoperative PNI of ≥ 52 (pre-PNI(High)), preoperative PNI of < 52 (pre-PNI(Low)), postoperative PNI of ≥ 49 (post-PNI(High)), and postoperative PNI of < 49 (pre-PNI(Low))...
October 12, 2017: Surgery Today
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