Hironobu Suto, Takuro Fuke, Hiroyuki Matsukawa, Yasuhisa Ando, Minoru Oshima, Mina Nagao, Shigeo Takahashi, Toru Shibata, Hiroki Yamana, Hideki Kamada, Hideki Kobara, Hiroyuki Okuyama, Kensuke Kumamoto, Keiichi Okano
Background : The efficacy of neoadjuvant chemoradiotherapy (NACRT) followed by pancreatoduodenectomy (PD) in elderly patients with pancreatic ductal adenocarcinoma (PDAC) remains unclear. Methods : This retrospective analysis of prospectively collected data examined the effect of NACRT followed by PD in elderly patients with PDAC. A total of 112 patients with resectable (R-) and borderline resectable (BR-) PDAC, who were planned for PD and received NACRT between 2009 and 2022, were assessed. Changes induced by NACRT, surgical outcomes, nutritional status, renal and endocrine functions, and prognosis were compared between elderly (≥75 years, n = 43) and non-elderly (<75 years, n = 69) patients over two years following PD...
February 21, 2024: Journal of Clinical Medicine