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https://www.readbyqxmd.com/read/27896408/is-routine-prophylactic-cholecystectomy-necessary-during-gastrectomy-for-gastric-cancer
#1
Jun Kimura, Chikara Kunisaki, Ryo Takagawa, Hirochika Makino, Michio Ueda, Mitsuyoshi Ota, Mari Oba, Takashi Kosaka, Hirotoshi Akiyama, Itaru Endo
BACKGROUND: Performing routine prophylactic cholecystectomy during gastrectomy in gastric cancer patients has been controversial. The frequency of cholelithiasis, cholecystitis, and cholangitis after gastrectomy has not been reported for large patient populations, so we carried out this retrospective study to aid the assessment of the necessity for prophylactic cholecystectomy. METHODS: This retrospective study reviewed 969 patients with gastric cancer who underwent distal gastrectomies with Billroth I reconstructions (DG) or total gastrectomies with Roux-en-Y reconstructions (TG), preserving the gallbladder, between January 2000 and May 2012...
November 28, 2016: World Journal of Surgery
https://www.readbyqxmd.com/read/27892720/association-between-chronic-pancreatitis-and-pyogenic-liver-abscess-a-nationwide-population-study
#2
Chih-Wei Tseng, Yu-Tso Chen, Cheng-Li Lin, Ji-An Liang
BACKGROUND: The relationship between chronic pancreatitis (CP) and subsequent pyogenic liver abscess (PLA) is not well understood. METHODS: We investigated the risk of PLA in patients with CP using inpatient claims data from the Taiwan National Health Insurance Program for the period 2000-2010, we identified 17,810 patients with chronic pancreatitis (CP group) and 71,240 patients without CP (non-CP group). Both cohorts were followed until a diagnosis of PLA, until they were censored from the study because of loss to follow-up, death, or termination of insurance, or until the study cut-off date of December 31, 2011...
November 28, 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/27874953/the-expression-of-b7-h3-and-b7-h4-in-human-gallbladder-carcinoma-and-their-clinical-implications
#3
C-L Liu, X-X Zang, H Huang, H Zhang, C Wang, Y-L Kong, H-Y Zhang
OBJECTIVE: To investigate the expression of B7-H3 and B7-H4 and their clinical implications in human gallbladder carcinoma. PATIENTS AND METHODS: The expression of B7-H3 and B7-H4 in the 252 samples (126 cases of chronic cholecystitis and 126 cases of gallbladder cancer) was detected by the streptavidin-peroxidase immunohistochemical method, and their associations with tumor classification, clinical grade, and recurrence were assessed. RESULTS: In chronic cholecystitis tissue, B7-H3 and B7-H4 were not detected...
November 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27770143/-1-h-nuclear-magnetic-resonance-nmr-based-serum-metabolomics-of-human-gallbladder-inflammation
#4
Raj Kumar Sharma, Kumudesh Mishra, Alvina Farooqui, Anu Behari, Vinay Kumar Kapoor, Neeraj Sinha
OBJECTIVE AND DESIGN: We present in this article (1)H nuclear magnetic resonance (NMR)-based metabolic approach to screen the serum metabolic alterations in human gallbladder inflammation with chronic cholecystitis (CC). MATERIAL/METHODS: Total of 71 human serum samples was divided into two groups, (n = 41, CC) and (n = 30 control). (1)H NMR metabolic profiling was carried out for investigation of metabolic alterations. Multivariate statistical analysis was applied for pattern recognition and identification of metabolites playing crucial role in gallbladder inflammation...
October 21, 2016: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/27769047/the-microrna-mir-33a-suppresses-il-6-induced-tumor-progression-by-binding-twist-in-gallbladder-cancer
#5
Mingdi Zhang, Wei Gong, Bin Zuo, Bingfeng Chu, Zhaohui Tang, Yong Zhang, Yong Yang, Di Zhou, Mingzhe Weng, Yiyu Qin, Mingzhe Ma, Alex Jiang, Fei Ma, Zhiwei Quan
Cytokine is a key molecular link between chronic inflammation and gallbladder cancer (GBC) progression. The potential mechanism of cytokine-associated modulation of microRNAs (miRNAs) expression in GBC progression is not fully understood. In this study, we investigated the biological effects and prognostic significance of interleukin-6 (IL-6) -induced miRNAs in the development of GBC. We identify that inflammatory cytokine, IL-6 promotes proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) of GBC both in vitro and in vivo...
October 15, 2016: Oncotarget
https://www.readbyqxmd.com/read/27747125/gallbladder-volvulus-in-a-patient-with-type-i-choledochal-cyst-a-case-report-and-review-of-the-literature
#6
George Younan, Max Schumm, Fadwa Ali, Kathleen K Christians
Introduction. Gallbladder volvulus is a rare, potentially fatal condition unless diagnosed and treated early. Choledochal cysts are rare congenital malformations of the biliary tree predisposing to different pathologies and posing the risk of degradation into cholangiocarcinoma and gallbladder cancer. Dealing with both diseases at once has not been published yet in the literature. Presentation of Case. We report a case of gallbladder volvulus in an elderly female who happened to have a concomitant type I choledochal cyst...
2016: Case Reports in Surgery
https://www.readbyqxmd.com/read/27730536/acute-acalculous-cholecystitis-due-to-breast-cancer-metastasis-to-the-cystic-duct
#7
Masakazu Hashimoto, Kei Koide, Michinori Arita, Koji Kawaguchi, Masakazu Tokunaga, Yoshihiro Mikuriya, Toshiyuki Iwamoto
BACKGROUND: Acute acalculous cholecystitis (AAC) is a relatively rare disorder of the gallbladder. Breast cancer recurrence more than 10 years after curative surgery is also infrequent. CASE PRESENTATION: Here, we report a case of a 59-year-old woman who presented with right flank pain. Her medical history included a lumpectomy for cancer of the left breast 12 years prior. Laboratory tests showed a severe inflammatory reaction and mild liver function abnormalities...
December 2016: Surgical Case Reports
https://www.readbyqxmd.com/read/27648157/unexpected-gallbladder-cancer-surgical-strategies-and-prognostic-factors
#8
EDITORIAL
Gennaro Clemente
Gallbladder cancer is the most common tumor of the biliary tract and it is associated with a poor prognosis. Unexpected gallbladder cancer is a cancer incidentally discovered, as a surprise, at the histological examination after cholecystectomy for gallstones or other indications. It is a potentially curable disease, with an intermediate or good prognosis in most cases. An adequate surgical strategy is mandatory to improve the prognosis and an adjunctive radical resection may be required depending on the depth of invasion...
August 27, 2016: World Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/27609089/-persistent-elevation-of-ca-19-9-and-an-unexpected-finding-a-case-report
#9
Luis Manuel Souza-Gallardo, Mauricio de la Fuente-Lira, Roberto Galaso-Trujillo, José Luis Martínez-Ordaz
BACKGROUND: Tumour markers are substances produced by the tumour itself, or by the host in response to a tumour. These markers could be measured either in the blood or in body secretions. One of the most common tumour markers used in gastrointestinal diseases is Ca 19-9. It is the marker most used for pancreatic cancer, but can be elevated in many benign processes. Thus, it is not a specific marker. CLINICAL CASE: The case is presented of a male patient with 4 years of moderate abdominal pain, weight loss, and persistent elevation of Ca 19-9...
September 5, 2016: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/27579782/poly-styrenesulfonate-modified-ni-ti-layered-double-hydroxide-film-a-smart-drug-eluting-platform
#10
Naijian Ge, Donghui Wang, Feng Peng, Jinhua Li, Yuqin Qiao, Xuanyong Liu
Drug-eluting stents (DESs) are widely used in the palliative treatment of many kinds of cancers. However, the covered polymers used in DESs are usually associated with stent migration and acute cholecystitis. Therefore, developing noncovered drug-loading layers on metal stents is of great importance. In this work, Ni-Ti layered double hydroxide (Ni-Ti LDH) films were prepared on the surface of nitinol via hydrothermal treatment, and the LDH films were further modified by poly(styrenesulfonate) (PSS). The anticancer drug doxorubicin could be effectively loaded onto the modified films, and drug release could be smartly controlled by the pH...
September 21, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27566055/percutaneous-transhepatic-versus-eus-guided-gallbladder-drainage-for-malignant-cystic-duct-obstruction
#11
Jin Ho Choi, Hyoung Woo Kim, Jong-Chan Lee, Kyu-Hyun Paik, Nak Jong Seong, Chang Jin Yoon, Jin-Hyeok Hwang, Jaihwan Kim
BACKGROUND AND AIMS: Endoscopic ultrasound-guided gallbladder drainage (EUS-GBD) has been proposed as an alternative management strategy for acute cholecystitis caused by malignant cystic duct obstruction in patients for whom surgery is not an option. This study aimed to compare the results of EUS-GBD with those of percutaneous transhepatic gallbladder drainage (PTGBD) for palliative management of malignant cystic duct obstruction with acute cholecystitis or symptomatic gallbladder hydrops...
August 24, 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27563024/muc-expression-in-gallbladder-epithelial-tissues-in-cholesterol-associated-gallbladder-disease
#12
Kyo-Sang Yoo, Ho Soon Choi, Dae Won Jun, Hang Lak Lee, Oh Young Lee, Byung Chul Yoon, Kyeong Geun Lee, Seung Sam Paik, Yong Seok Kim, Jin Lee
BACKGROUND/AIMS: Gallstone pathogenesis is linked to mucin hypersecretion and bacterial infection. Several mucin genes have been identified in gallbladder epithelial cells (GBECs). We investigated MUC expression in cholesterol-associated gallbladder disease and evaluated the relationship between mucin and bacterial infection. METHODS: The present study involved 20 patients with cholesterol stones with cholecystitis, five with cholesterol stones with cholesterolosis, six with cholesterol polyps, two with gallbladder cancer, and six controls...
September 15, 2016: Gut and Liver
https://www.readbyqxmd.com/read/27508070/gallstones-new-insights-into-an-old-story
#13
REVIEW
Evan Tiderington, Sum P Lee, Cynthia W Ko
Gallstones, particularly cholesterol gallstones, are common in Western populations and may cause symptoms such as biliary colic or complications such as acute cholecystitis or gallstone pancreatitis. Recent studies have allowed for a better understanding of the risk of symptoms or complications in patients with gallstones. In addition, newer data suggest an association of gallstones with overall mortality, cardiovascular disease, gastrointestinal cancers, and non-alcoholic fatty liver disease. Knowledge of appropriate indications and timing of cholecystectomy, particularly for mild biliary pancreatitis, has gradually accumulated...
2016: F1000Research
https://www.readbyqxmd.com/read/27485060/effects-of-rowachol-on-prevention-of-postcholecystectomy-pain-after-laparoscopic-cholecystectomy-prospective-multicenter-randomized-controlled-trial
#14
In Woong Han, O Choel Kwon, Min Gu Oh, Yoo Shin Choi, Seung Eun Lee
BACKGROUND: Postcholecystectomy pain (PCP) is characterized by abdominal pain after cholecystectomy. However, prevention of PCP is not well known yet. The purpose of this study was to determine whether Rowachol might be useful in preventing PCP. METHODS: Between May 2013 and January 2014, a total of 138 patients with gallbladder disease who were scheduled to undergo laparoscopic cholecystectomy were randomly assigned to orally receive 100 mg Rowachol or placebo three times daily for 3 months after surgery...
August 2016: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/27475647/quantification-of-circulating-free-dna-as-a-diagnostic-marker-in-gall-bladder-cancer
#15
Swati Kumari, Shikha Tewari, Nuzhat Husain, Akash Agarwal, Anshuman Pandey, Ashish Singhal, Mohtashim Lohani
Gall bladder Carcinoma (GBC) is the fifth most common cancer of the digestive tract and frequently diagnosed in late stage of disease. Estimation of circulating free DNA (cfDNA) in serum has been applied as a "liquid biopsy" in several deep seated malignancies. Its value in diagnosis of gall bladder carcinoma has not been studied. The present study was designed to assess the role of cfDNA in the diagnosis of GBC and correlate levels with the TNM stage. Serum was collected from 34 patients with GBC and 39 age and sex matched controls including 22 cholecystitis and 17 healthy individuals...
July 30, 2016: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/27461588/yttrium-90-radioembolization-of-advanced-unresectable-breast-cancer-liver-metastases-a-single-center-experience
#16
Claus Christian Pieper, Carsten Meyer, Kai E Wilhelm, Wolfgang Block, Jennifer Nadal, Hojjat Ahmadzadehfar, Winfried Albert Willinek, Hans Heinz Schild
PURPOSE: To determine value of transarterial radioembolization (TARE) for palliative treatment of unresectable liver-dominant breast metastases (LdBM) and to determine prognostic parameters. MATERIALS AND METHODS: Records of patients undergoing TARE for progressing LdBM between June 2006 and March 2015 were retrospectively reviewed; 44 female patients (mean age 56.1 y; range, 34.9-85.3 y) underwent 69 TAREs (56 resin-based, 13 glass-based). Of 44 patients, 42 had bilobar disease...
September 2016: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/27457076/gallbladder-small-cell-carcinoma-a-case-report-and-literature-review
#17
Toshiyuki Adachi, Masashi Haraguchi, Junji Irie, Tomoko Yoshimoto, Ryohei Uehara, Shinichiro Ito, Hirotaka Tokai, Kazumasa Noda, Nobuhiro Tada, Masataka Hirabaru, Keiji Inoue, Shigeki Minami, Susumu Eguchi
Gallbladder small cell carcinoma (SCC) comprises only 0.5 % of all gallbladder cancer and consists of aggressive tumors with poor survival outcomes against current treatments. These tumors are most common in elderly females, particularly those with cholecystolithiasis. We report the case of a 79-year-old woman with gallbladder small cell carcinoma. The patient had intermittent right upper quadrant abdominal pain and was admitted to our hospital due to suspected acute cholecystitis. She regularly received medical treatment for diabetes, hypertension, and dyslipidemia...
December 2016: Surgical Case Reports
https://www.readbyqxmd.com/read/27456958/laparoscopic-management-of-gallbladder-cancer-a-stepwise-approach
#18
Suguru Yamashita, Evelyne Loyer, Yun Shin Chun, Milind Javle, Jeffrey E Lee, Jean-Nicolas Vauthey, Claudius Conrad
BACKGROUND: In the era of laparoscopic cholecystectomy, incidentally discovered gallbladder cancer (IGBC) has become a common clinical presentation.1 A consensus exists that radical resection should be performed for IGBC patients with T1b or more advanced tumors.2 Although the oncologic safety of laparoscopic treatment for selected patients with gallbladder cancer (GBC) has been demonstrated, a laparoscopic approach for IGBC remains uncommonly practiced due to the technical challenge of the frequently reoperative cases...
July 25, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27430276/incorporating-yttrium-90-trans-arterial-radioembolization-tare-in-the-treatment-of-metastatic-pancreatic-adenocarcioma-a-single-center-experience
#19
Alexander Y Kim, Keith Unger, Hongkun Wang, Michael J Pishvaian
BACKGROUND: The purpose of this retrospective study was to evaluate the efficacy of incorporating trans-arterial radioembolization (TARE) with systemic chemotherapy in the treatment of liver-dominant metastatic pancreatic ductal adenocarcinoma, with the aim of destroying liver metastases and improving patient outcomes. METHODS: We retrospectively evaluated 16 patients with liver-dominant metastatic pancreatic ductal adenocarcinoma who underwent TARE between February 2012 and August 2015; 15 of these patients also underwent concurrent systemic chemotherapy...
2016: BMC Cancer
https://www.readbyqxmd.com/read/27282268/antireflux-metal-stent-as-a-first-line-metal-stent-for-distal-malignant-biliary-obstruction-a-pilot-study
#20
Tsuyoshi Hamada, Hiroyuki Isayama, Yousuke Nakai, Osamu Togawa, Naminatsu Takahara, Rie Uchino, Suguru Mizuno, Dai Mohri, Hiroshi Yagioka, Hirofumi Kogure, Saburo Matsubara, Natsuyo Yamamoto, Yukiko Ito, Minoru Tada, Kazuhiko Koike
Background/Aims: In distal malignant biliary obstruction, an antireflux metal stent (ARMS) with a funnel-shaped valve is effective as a reintervention for metal stent occlusion caused by reflux. This study sought to evaluate the feasibility of this ARMS as a first-line metal stent. Methods: Patients with nonresectable distal malignant biliary obstruction were identified between April and December 2014 at three Japanese tertiary centers. We retrospectively evaluated recurrent biliary obstruction and adverse events after ARMS placement...
June 13, 2016: Gut and Liver
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