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Spine degenerative disease

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https://www.readbyqxmd.com/read/28108403/risk-of-cement-leakage-and-pulmonary-embolism-by-bone-cement-augmented-pedicle-screw-fixation-of-the-thoracolumbar-spine
#1
Insa Janssen, Yu-Mi Ryang, Jens Gempt, Stefanie Bette, Julia Gerhardt, Jan Kirschke, Bernhard Meyer
BACKGROUND: Cement augmented pedicle screw instrumentation (CAPSI) of the thoracolumbar spine is indicated in osteoporosis or osteopenia to improve pullout strength and biomechanical stability of pedicle screws (PS). Only few studies report on the incidence of pulmonary cement embolism or other complications associated with CAPSI. PURPOSE: Aim of this retrospective study was to assess the rate of CAPSI associated complications. STUDY DESIGN: Retrospective cohort study...
January 17, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28093693/a-simple-post-mortem-room-angiography-method-for-the-investigation-of-traumatic-basal-subarachnoid-hemorrhage
#2
Christopher P Johnson, Mike Murphy, George A Johnson, Stephen M Wills, Jonathan E Medcalf
Identifying the site of vascular bleeding in fatal cases of traumatic basal subarachnoid hemorrhage (TBSAH) is important, but can be very difficult to achieve when there is extensive blood clot in the posterior cranial fossa. Post mortem angiography in these circumstances has been reported previously but with mixed results, and is rarely used in current practice within the United Kingdom. We have developed a simple and effective post mortem angiography method, using fluoroscopy and clear modern contrast medium, suitable for use in the autopsy room...
January 17, 2017: Forensic Science, Medicine, and Pathology
https://www.readbyqxmd.com/read/28088900/synaptic-plasticity-dementia-and-alzheimer-disease
#3
Pietro Giusti, Stephen D Skaper, Laura Facci, Morena Zusso
Neuroplasticity is not only shaped by learning and memory but is also a mediator of responses to neuron attrition and injury (compensatory plasticity). As an ongoing process it reacts to neuronal cell activity and injury, death, and genesis, which encompasses the modulation of structural and functional processes of axons, dendrites, and synapses. The range of structural elements that comprise plasticity includes long-term potentiation (a cellular correlate of learning and memory), synaptic efficacy and remodelling, synaptogenesis, axonal sprouting and dendritic remodelling, and neurogenesis and recruitment...
January 13, 2017: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/28067696/multidisciplinary-evaluation-leads-to-the-decreased-utilization-of-lumbar-spine-fusion-an-observational-cohort-pilot-study
#4
Vijay Yanamadala, Yourie Kim, Quinlan D Buchlak, Anna K Wright, James Babington, Andrew Friedman, Robert S Mecklenburg, Farrokh Farrokhi, Jean-Christophe Leveque, Rajiv K Sethi
STUDY DESIGN: Observational cohort pilot study. OBJECTIVE: To determine the impact of multidisciplinary conference on treatment decisions for lumbar degenerative spine disease. SUMMARY OF BACKGROUND DATA: Multidisciplinary decision making improves outcomes in many disciplines. The lack of integrated systems for comprehensive care for spinal disorders has contributed to the inappropriate overutilization of spine surgery in the United States...
January 6, 2017: Spine
https://www.readbyqxmd.com/read/28059685/resolution-of-the-more-anteriorly-positioned-psoas-muscle-following-correction-of-spinal-sagittal-alignment-from-spondylolisthesis-case-report
#5
Hasan R Syed, Kurt Yaeger, Faheem A Sandhu
Several studies have described the radiographic, histological, and morphological changes to the paraspinal muscle in patients with chronic low-back pain due to degenerative diseases of the spine. Gross anatomical illustrations have shown that the psoas muscle lies lateral to the L4-5 vertebrae and subsequently thins and dissociates from the vertebral body at L5-S1 in a ventrolateral course. A "rising psoas" may influence the location of the lumbar plexus and result in transient neurological injury on lateral approach to the spine...
January 6, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28035040/of-microtubules-and-memory-implications-for-microtubule-dynamics-in-dendrites-and-spines
#6
Erik W Dent
Microtubules (MTs) are cytoskeletal polymers composed of repeating subunits of tubulin that are ubiquitously expressed in eukaryotic cells. They undergo a stochastic process of polymerization and depolymerization from their plus ends termed dynamic instability. MT dynamics is an ongoing process in all cell types and has been the target for the development of several useful anticancer drugs, which compromise rapidly dividing cells. Recent studies also suggest that MT dynamics may be particularly important in neurons, which develop a highly polarized morphology, consisting of a single axon and multiple dendrites that persist throughout adulthood...
January 1, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28013419/clinical-outcomes-after-minimally-invasive-transforaminal-lumbar-interbody-fusion-and-lateral-lumbar-interbody-fusion-for-treatment-of-degenerative-lumbar-disease-a-systematic-review-and-meta-analysis
#7
REVIEW
Gun Keorochana, Kitipong Setrkraising, Patarawan Woratanarat, Alisara Arirachakaran, Jatupon Kongtharvonskul
The surgical procedures used for arthrodesis in the lumbar spine for degenerative lumbar diseases remain controversial. This systematic review aims to assess and compare clinical outcomes along with the complications and fusion of each technique (minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) or minimally invasive lateral lumbar interbody fusion (MIS LLIF)) for treatment of degenerative lumbar diseases. Relevant studies were identified from Medline and Scopus from inception to July 19, 2016 that reported Oswestry Disability Index (ODI), back and leg pain visual analog score (VAS), postoperative complications, and fusion of either technique...
December 24, 2016: Neurosurgical Review
https://www.readbyqxmd.com/read/28005935/a-biomechanical-stability-study-of-extraforaminal-lumbar-interbody-fusion-on-the-cadaveric-lumbar-spine-specimens
#8
Song Guo, Cheng Zeng, Meijun Yan, Yingchao Han, Dongdong Xia, Guixin Sun, Lijun Li, Mingjie Yang, Jun Tan
BACKGROUND: Transforaminal lumbar interbody fusion (TLIF) is an effective surgery for lumbar degenerative disease. However, this fusion technique requires resection of inferior facet joint to provide access for superior facet joint resection, which results in reduced lumbar spinal stability and unnecessary trauma. We have previously developed extraforaminal lumbar interbody fusion (ELIF) that can avoid back muscle injury with direct nerve root decompression. This study aims to show that ELIF enhances lumbar spinal stability in comparison to TLIF by comparing lumbar spinal stability of L4-L5 range of motion (ROM) on 12 cadaveric spine specimens after performing TLIF or ELIF...
2016: PloS One
https://www.readbyqxmd.com/read/28005616/five-year-reoperation-rates-of-2-level-lumbar-total-disk-replacement-versus-fusion-results-of-a-prospective-randomized-clinical-trial
#9
Kris Radcliff, Jeffrey Spivak, Bruce Darden, Michael Janssen, Thierry Bernard, Jack Zigler
STUDY DESIGN: Long-term analysis of prospective randomized clinical trial data. SUMMARY OF BACKGROUND DATA: Lumbar total disk replacement (TDR) has been found to have equivalent or superior clinical outcomes compared with fusion and decreased radiographic incidence of adjacent level degeneration in single-level cases. OBJECTIVE: The purpose of this particular analysis was to determine the incidence and risk factors for secondary surgery in patients treated with TDR or circumferential fusion at 2 contiguous levels of the lumbar spine...
December 21, 2016: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28004632/adjacent-segment-pathology-progressive-disease-course-or-a-product-of-iatrogenic-fusion
#10
Andrew Jack, Godefroy Hardy St-Pierre, Andrew Nataraj
OBJECTIVE: Cervical spine clinical adjacent segment pathology (CASP) has a reported 3% annual incidence and 26% ten-year prevalence. Its pathophysiology remains controversial, whether due to mechanical stress of a fusion segment on adjacent levels or due to patient propensity to develop progressive degenerative change. We investigate this relationship by comparing prevalence of CASP in traumatic and spondylotic patient cohorts. METHOD: A retrospective review of traumatic cervical spine fusion cases performed by the local group of neurosurgeons from 2004-2008 was completed...
January 2017: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/28002363/comparison-of-outcomes-of-single-level-anterior-cervical-discectomy-with-fusion-and-single-level-artificial-cervical-disc-replacement-for-single-level-cervical-degenerative-disc-disease
#11
Praveen Kumar Pandey, Inder Pawar, Jyoti Gupta, Raaghav Rai Verma
STUDY DESIGN: A single-center, prospective comparative study of prospectively collected outcomes, with a minimum 12 months follow-up. OBJECTIVES: The primary purpose of the study is to investigate the clinical, functional, and radiological outcomes of cervical total disc replacement (CTDR) in comparison with anterior cervical discectomy and fusion (ACDF) in the treatment of single-level cervical disc degenerative disease, prospectively. SUMMARY OF BACKGROUND DATA: CTDR has recently been an alternative to ACDF in cervical disc degenerative disease to preserve the motion at the treated level...
January 1, 2017: Spine
https://www.readbyqxmd.com/read/27998660/prosthetic-dislocation-and-revision-after-primary-total-hip-arthroplasty-in-lumbar-fusion-patients-a-propensity-score-matched-pair-analysis
#12
Dean C Perfetti, Ran Schwarzkopf, Aaron J Buckland, Carl B Paulino, Jonathan M Vigdorchik
BACKGROUND: Lumbar-pelvic fusion reduces the variation in pelvic tilt in functional situations by reducing lumbar spine flexibility, which is thought to be important in maintaining stability of a total hip arthroplasty (THA). We compared dislocation and revision rates for patients with lumbar fusion and subsequent THA to a matched comparison cohort with hip and spine degenerative changes undergoing only THA. METHODS: We identified patients in New York State who underwent primary elective lumbar fusion for degenerative disc disease pathology and subsequent THA between January 2005 and December 2012...
November 23, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/27997508/cost-variation-of-anterior-cervical-fusions-in-elderly-medicare-beneficiaries
#13
Varun Puvanesarajah, David J Kirby, Amit Jain, Brian C Werner, Hamid Hassanzadeh
STUDY DESIGN: Retrospective database review OBJECTIVE.: To determine how demographics and comorbid diagnoses influence hospital costs during admission for anterior cervical fusions (ACFs) in the elderly Medicare population. SUMMARY OF BACKGROUND DATA: Elective ACFs to treat degenerative cervical pathology are extremely common within the elderly population. Though it is well known that every patient has a significantly different medical profile that guides treatment and post-operative care, little information is available regarding how hospital costs vary from patient to patient...
December 16, 2016: Spine
https://www.readbyqxmd.com/read/27994778/intrinsic-vertebral-markers-for-spinal-level-localization-in-anterior-cervical-spine-surgery-a-preliminary-report
#14
Deepak Kumar Jha, Anil Thakur, Mukul Jain, Arvind Arya, Chandrabhushan Tripathi, Rima Kumari, Suman Kushwaha
STUDY DESIGN: Prospective clinical study. PURPOSE: To observe the usefulness of anterior cervical osteophytes as intrinsic markers for spinal level localization (SLL) during sub-axial cervical spinal surgery via the anterior approach. OVERVIEW OF LITERATURE: Various landmarks, such as the mandibular angle, hyoid bone, thyroid cartilage, first cricoid ring, and C6 carotid tubercle, are used for gross cervical SLL; however, none are used during cervical spinal surgery via the anterior approach...
December 2016: Asian Spine Journal
https://www.readbyqxmd.com/read/27990418/finite-element-study-of-a-lumbar-intervertebral-disc-nucleus-replacement-device
#15
Jessica S Coogan, W Loren Francis, Travis D Eliason, Todd L Bredbenner, Brian D Stemper, Narayan Yoganandan, Frank A Pintar, Daniel P Nicolella
Nucleus replacement technologies are a minimally invasive alternative to spinal fusion and total disc replacement that have the potential to reduce pain and restore motion for patients with degenerative disc disease. Finite element modeling can be used to determine the biomechanics associated with nucleus replacement technologies. The current study focuses on a new nucleus replacement device designed as a conforming silicone implant with an internal void. A validated finite element model of the human lumbar L3-L4 motion segment was developed and used to investigate the influence of the nucleus replacement device on spine biomechanics...
2016: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/27988343/influence-of-the-mental-health-status-on-a-new-measure-of-objective-functional-impairment-in-lumbar-degenerative-disc-disease
#16
Martin N Stienen, Nicolas R Smoll, Holger Joswig, Jan Snagowski, Marco V Corniola, Karl Schaller, Gerhard Hildebrandt, Oliver P Gautschi
BACKGROUND CONTEXT: The Timed Up and Go (TUG) test has recently been proposed as a simple and standardized measure for objective functional impairment (OFI) in patients with lumbar degenerative disc disease (DDD). PURPOSE: The study aimed to explore the relationship between a patient's mental health status and both patient-reported outcome measures (PROMs) and TUG test results. STUDY DESIGN/SETTING: This is a prospective institutional review board-approved two-center study...
December 14, 2016: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/27980494/in-vivo-osteoinduction-evaluating-2-beta-coxatene-as-an-immunoinductive-compound-and-novel-ingredient-for-joint-support
#17
Katherine Spinks, James J Scaffidi
CONTEXT: Osteoarthritis (OA) is a degenerative joint disease characterized by progressive loss of articular cartilage. Many treatments lack the ability to stimulate the growth of native cartilage tissue while they simultaneously increase joint comfort. For the past few decades, dietary supplements have been investigated for the ability to both address joint inflammation and stimulate cartilage tissue. OBJECTIVES: The present study intended to examine the supplement's in vivo osteoinductive capabilities and clinical efficacy for overall joint health...
October 2016: Integrative Medicine
https://www.readbyqxmd.com/read/27919248/bone-mineral-density-in-patients-with-multiple-sclerosis-hereditary-ataxia-or-hereditary-spastic-paraplegia-after-at-least-10%C3%A2-years-of-disease-a-case-control-study
#18
Cecilia Smith Simonsen, Elisabeth Gulowsen Celius, Cathrine Brunborg, Chantal Tallaksen, Erik Fink Eriksen, Trygve Holmøy, Stine Marit Moen
BACKGROUND: Although disability is considered the main cause of low bone mineral density (BMD) in multiple sclerosis (MS), other factors related to the disease process or treatment could also be involved. The aim of this study was to assess whether patients with MS are more likely to develop low BMD (osteopenia or osteoporosis) than patients with the non-inflammatory neurological diseases Hereditary Spastic Paraplegia (HSP) and Hereditary Ataxia (HA). METHODS: We performed a case control study comparing BMD (spine, hip and total body) and biochemical measures of bone metabolism in 91 MS patients and 77 patients with HSP or HA, matched for age, gender and disability...
December 5, 2016: BMC Neurology
https://www.readbyqxmd.com/read/27913961/prediction-of-postoperative-clinical-recovery-of-drop-foot-attributable-to-lumbar-degenerative-diseases-via-a-bayesian-network
#19
Shota Takenaka, Hiroyuki Aono
BACKGROUND: Drop foot resulting from degenerative lumbar diseases can impair activities of daily living. Therefore, predictors of recovery of this symptom have been investigated using univariate or/and multivariate analyses. However, the conclusions have been somewhat controversial. Bayesian network models, which are graphic and intuitive to the clinician, may facilitate understanding of the prognosis of drop foot resulting from degenerative lumbar diseases. QUESTIONS/PURPOSES: (1) To show a layered correlation among predictors of recovery from drop foot resulting from degenerative lumbar diseases; and (2) to develop support tools for clinical decisions to treat drop foot resulting from lumbar degenerative diseases...
December 2, 2016: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/27907828/surgical-apgar-score-in-patients-undergoing-lumbar-fusion-for-degenerative-spine-diseases
#20
Chien-Yu Ou, Shih-Yuan Hsu, Jian-Hao Huang, Yu-Hua Huang
OBJECTIVE: Lumbar fusion is a procedure broadly performed for degenerative diseases of spines, but it is not without significant morbidities. Surgical Apgar Score (SAS), based on intraoperative blood loss, blood pressure, and heart rate, was developed for prognostic prediction in general and vascular operations. We aimed to examine whether the application of SAS in patients undergoing fusion procedures for degeneration of lumbar spines predicts in-hospital major complications. METHODS: One hundred and ninety-nine patients that underwent lumbar fusion operation for spine degeneration were enrolled in this retrospective study...
January 2017: Clinical Neurology and Neurosurgery
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