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https://www.readbyqxmd.com/read/28105226/expression-of-epidermal-growth-factor-like-domain-7-may-be-a-predictive-marker-of-the-effect-of-neoadjuvant-chemotherapy-for-locally-advanced-uterine-cervical-cancer
#1
Makoto Yamauchi, Takeshi Fukuda, Takuma Wada, Masaru Kawanishi, Kenji Imai, Reiko Tasaka, Tomoyo Yasui, Toshiyuki Sumi
Neoadjuvant chemotherapy (NAC) followed by hysterectomy may be effective for the treatment of locally advanced uterine cervical cancer and improve patient prognosis. It is important to identify markers that are able to predict whether NAC may be successful. Epidermal growth factor-like domain 7 (EGFL7) regulates vascular sprouting in blood vessel formation. In numerous types of human cancer, EGFL7 is upregulated and inhibits endothelial cell adhesion molecules, decreasing vascular tightness and, thus, increasing vascular permeability...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28104497/robot-assisted-surgery-in-gynecologic-cancers
#2
REVIEW
V Zanagnolo, A Garbi, M T Achilarre, L Minig
Robotic-assisted surgery is a technological advancement that facilitates the application of minimally invasive techniques for complex operations in gynecological oncology. The objective of this article is to review the literature regarding the role of robotic-assisted surgery to treat women with gynecologic cancers. The majority of publications on robotic surgery are still retrospective or descriptive in nature, however, the data for managing patients with a robotic assisted approach shows comparable, and at times an improved outcomes compared to both laparoscopy (2D) and laparotomy approaches...
January 16, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28104496/risk-factors-clinical-presentation-and-outcomes-for-abdominal-wall-endometriosis
#3
Zaraq Khan, Valentina Zanfagnin, Sherif A El-Nashar, Bimbola O Famuyide, Gaurang S Daftary, Matthew R Hopkins
STUDY OBJECTIVE: To evaluate risk factors, presentation and outcomes in cases of abdominal wall endometriosis. DESIGN: This is a case control study. DESIGN CLASSIFICATION: Canadian Task Force classification II-2 SETTING: Academic medical center PATIENTS: Total of 102 (34 cases and 68 controls) were included. INTERVENTION(S): Surgical resection of abdominal wall endometriosis. MAIN OUTCOME MEASURE(S): Cases underwent surgical excision for abdominal wall endometriosis at Mayo Clinic from January 1, 2000 through December 31, 2013...
January 16, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28104403/a-model-to-predict-risk-of-blood-transfusion-after-gynecologic-surgery
#4
Jamie Stanhiser, Kevin Chagin, J Eric Jelovsek
BACKGROUND: A model that predicts a patient's risk of receiving a blood transfusion may facilitate selective preoperative testing and more efficient perioperative blood management utilization. OBJECTIVES: To construct and validate a model that predicts a patient's risk of receiving a blood transfusion after gynecologic surgery. STUDY DESIGN: 18,319 women who underwent gynecologic surgery at 10 institutions in a single health system by 116 surgeons between January 2010 and June 2014 were analyzed...
January 16, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28100383/-hiv-antibody-detection-results-in-patients-seeking-medical-care-in-peking-union-medical-college-hospital-2003-2014
#5
X J Song, Z F Qiu, W Cao, J Xie, Z J Zhang, S X Xu, T S Li
Objective: To better understand the infection status of HIV in the patients seeking medical care in Peking Union Medical College Hospital. Methods: The HIV detection data of the patients in the hospital from 2003-2014 were collected for a statistical analysis with software SPSS 19.0. Results: A total of 715 421 patients were screened, and 1 012 (0.14%) patients were HIV positive, and HIV infection were confirmed in 776 (0.11%) patients by Western Blot testing. The detection rate of HIV infection increased from 0...
January 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28099697/applicability-of-the-modified-acog-sgo-referral-criteria-for-adnexal-mass-within-a-limited-resource-setting
#6
Ashley Battarbee, Anna Strohl, Lindsay Zimmerman, Ashlesha Patel, Radha Burtch
OBJECTIVE: To evaluate the performance of the modified American Congress of Obstetricians and Gynecologists (ACOG)/Society of Gynecologic Oncology (SGO) referral guidelines in a high-risk limited-resource setting. METHODS: In a retrospective study, data were assessed for all women who underwent surgery for an adnexal mass at John H. Stroger Jr Hospital, Chicago, IL, USA, between July 2006 and July 2011. Sensitivity, specificity, and positive and negative predictive values were calculated both for actual practice referral patterns and for the modified ACOG/SGO guidelines...
January 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28099691/prospective-observational-study-comparing-traditional-laparoscopy-and-three-dimensional-laparoscopy-in-gynecologic-surgery
#7
Maria D Lara-Domínguez, Araceli López-Jiménez, Jacek P Grabowski, Jose E Arjona-Berral, Ignacio Zapardiel
OBJECTIVE: To compare perioperative details among patients who underwent gynecologic surgery between traditional laparoscopy and three-dimensional laparoscopy. METHOD: The present prospective non-randomized study enrolled all consecutive patients diagnosed with gynecologic pathology who underwent laparoscopic surgery at Reina Sofia Hospital, Cordoba, Spain between January 1 and April 30, 2014. Perioperative data, adverse events, and patient satisfaction were compared between patients who underwent treatment with two-dimensional and three-dimensional laparoscopic surgery techniques...
December 10, 2016: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28099310/national-institutes-of-health-funding-to-departments-of-orthopaedic-surgery-at-u-s-medical-schools
#8
Jason Silvestre, Jaimo Ahn, L Scott Levin
BACKGROUND: The National Institutes of Health (NIH) is the largest supporter of biomedical research in the U.S., yet its contribution to orthopaedic research is poorly understood. In this study, we analyzed the portfolio of NIH funding to departments of orthopaedic surgery at U.S. medical schools. METHODS: The NIH RePORT (Research Portfolio Online Reporting Tools) database was queried for NIH grants awarded to departments of orthopaedic surgery in 2014. Funding totals were determined for award mechanisms and NIH institutes...
January 18, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28098574/new-developments-in-robotics-and-single-site-gynecologic-surgery
#9
Catherine A Matthews
Within the last 10 years there have been significant advances in minimal-access surgery. Although no emerging technology has demonstrated improved outcomes or fewer complications than standard laparoscopy, the introduction of the robotic surgical platform has significantly lowered abdominal hysterectomy rates. While operative time and cost were higher in robotic-assisted procedures when the technology was first introduced, newer studies demonstrate equivalent or improved robotic surgical efficiency with increased experience...
January 17, 2017: Clinical Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28094037/identifying-risk-factors-for-occult-lower-extremity-lymphedema-using-computed-tomography-in-patients-undergoing-lymphadenectomy-for-gynecologic-cancers
#10
Miseon Kim, Dong Hoon Suh, Eun Joo Yang, Myong Cheol Lim, Jin Young Choi, Kidong Kim, Jae Hong No, Yong-Beom Kim
OBJECTIVE: To identify risk factors for lower extremity lymphedema (LEL) using computed tomographic (CT) scan in patients undergoing lymphadenectomy for gynecologic cancers. METHODS: We retrospectively reviewed 511 consecutive gynecologic cancer patients undergoing lymphadenectomy. Mean difference (3.77±3.14mm) of subcutaneous layer thicknesses between preoperative and postoperative 1-year CT scans of 106 patients with clinical LEL was used as an objective criterion for regrouping all the patients into those with mean difference >3...
January 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28094020/the-wertheim-hysterectomy-development-modifications-and-impact-in-the-present-day
#11
Alexa L Swailes, Allison Gockley, Rébécca Phaëton, Joshua P Kesterson
Ernst Wertheim was a pioneer in the history of the surgical treatment of cervical cancer. His English-language manuscript "The extended abdominal operation for carcinoma uteri (based on 500 operative cases)," which was published in 1912, detailed his standardization of the radical hysterectomy and formed the basis of the current treatment for early stage cervical cancer. We contextualize the Wertheim hysterectomy, emphasizing medical advances that allowed for its development and subsequent modification. We then discuss modifications to the originally proposed procedure, including a maximally extended parametrical resection pioneered by Takayama, and the addition of the Taussig en bloc lymph node dissection by Meigs, both of which afforded an improved mortality profile due to decreased disease recurrence...
January 13, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28089570/use-of-augmented-reality-in-laparoscopic-gynecology-to-visualize-myomas
#12
Nicolas Bourdel, Toby Collins, Daniel Pizarro, Clement Debize, Anne-Sophie Grémeau, Adrien Bartoli, Michel Canis
OBJECTIVE: To report the use of augmented reality (AR) in gynecology. DESIGN: AR is a surgical guidance technology that enables important hidden surface structures to be visualized in endoscopic images. AR has been used for other organs, but never in gynecology and never with a very mobile organ like the uterus. We have developed a new AR approach specifically for uterine surgery and demonstrated its use for myomectomy. SETTING: Tertiary university hospital...
January 12, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28089376/chemotherapy-completion-in-elderly-women-with-ovarian-primary-peritoneal-or-fallopian-tube-cancer-an-nrg-oncology-gynecologic-oncology-group-study
#13
Vivian E von Gruenigen, Helen Q Huang, Jan H Beumer, Heather A Lankes, William Tew, Thomas Herzog, Arti Hurria, Robert S Mannel, Tina Rizack, Lisa M Landrum, Peter G Rose, Ritu Salani, William H Bradley, Thomas J Rutherford, Robert V Higgins, Angeles Alvarez Secord, Gini Fleming
PURPOSE: A simple measure to predict chemotherapy tolerance in elderly patients would be useful. We prospectively tested the association of baseline Instrumental Activities of Daily Living (IADL) score with ability to complete 4 cycles of first line chemotherapy without dose reductions or >7days delay in elderly ovarian cancer patients. PATIENTS AND METHODS: Patients' age ≥70 along with their physicians chose between two regimens: CP (Carboplatin AUC 5, Paclitaxel 135mg/m(2)) or C (Carboplatin AUC 5), both given every 3weeks either after primary surgery or as neoadjuvant chemotherapy (NACT) with IADL and quality of life assessments performed at baseline, pre-cycle 3, and post-cycle 4...
January 12, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28080157/detection-of-recurrence-in-early-stage-endometrial-cancer-the-role-of-symptoms-and-routine-follow-up
#14
Mette Moustgaard Jeppesen, Ole Mogensen, Dorte Gilså Hansen, Maria Iachina, Malene Korsholm, Pernille Tine Jensen
BACKGROUND: Considerable controversy remains as to the optimal organization of endometrial cancer follow-up. AIM: To evaluate the relationship between the way recurrence was detected and survival after treatment for endometrial cancer. Further, to identify characteristics associated with a pre-scheduled examination in women with symptomatic recurrence. MATERIAL AND METHODS: All women with early stage endometrial cancer during 2005-2009 were included in a population-based historical cohort derived from the Danish Gynecological Cancer Database...
January 12, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28079780/subspecialty-influence-on-scientific-peer-review-for-an-obstetrics-and-gynecology-journal-with-a-high-impact-factor
#15
Laura I Parikh, Rebecca S Benner, Thomas W Riggs, Nicholas Hazen, Nancy C Chescheir
OBJECTIVE: To evaluate whether quality of peer review and reviewer recommendation differ based on reviewer subspecialty in obstetrics and gynecology and to determine the role of experience on reviewer recommendation. METHODS: We performed a retrospective cohort study of reviews submitted to Obstetrics & Gynecology between January 2010 and December 2014. Subspecialties were determined based on classification terms selected by each reviewer and included all major obstetrics and gynecology subspecialties, general obstetrics and gynecology, and nonobstetrics and gynecology categories...
January 9, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28079776/enhanced-recovery-program-and-length-of-stay-after-laparotomy-on-a-gynecologic-oncology-service-a-randomized-controlled-trial
#16
Elizabeth L Dickson, Erica Stockwell, Melissa A Geller, Rachel Isaksson Vogel, Sally A Mullany, Rahel Ghebre, Boris J N Witherhoff, Levi S Downs, Linda F Carson, Deanna Teoh, Michelle Glasgow, Matt Gerber, Colleen Rivard, Britt K Erickson, Jacob Hutchins, Peter A Argenta
OBJECTIVE: To estimate whether a rapid recovery program would reduce length of stay among patients undergoing laparotomy on a gynecologic oncology service. METHODS: We conducted a prospective, randomized, controlled trial comparing an enhanced recovery after surgery protocol with routine postoperative care among women undergoing laparotomy on the gynecologic oncology service. Protocol elements included: preoperative counseling, regional anesthesia, intraoperative fluid restriction, and early postoperative ambulation and feeding...
January 9, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28079663/general-anesthesia-and-fabry-disease-a-case-report
#17
Stefan Krüger, Albina Nowak, Torben Christoph Müller
Fabry disease is an inherited X-linked disorder characterized by the absence (in men) or deficiency (in women) in α-galactosidase A activity that causes a progressive accumulation of glycosphingolipids within lysosomes of cells of all the major organ systems. The subsequent organ damage that manifests in childhood and early adulthood presents a widely variable clinical picture of pain, hypertension, and cardiac, renal, nervous system, and lung dysfunction. We present 2 female patients with Fabry disease who required general anesthesia twice for gynecological and trauma surgery, respectively, and discuss their perioperative management based on new information in the medical literature...
January 11, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/28076592/assessment-of-laparoscopic-skills-of-gynecology-and-obstetrics-residents-after-a-training-program
#18
Carla Ferreira Kikuchi Fernandes, José Maria Cordeiro Ruano, Lea Mina Kati, Alberto Sinhiti Noguti, Manoel João Batista Castello Girão, Marair Gracio Ferreira Sartori
Objective: To evaluate laparoscopic skills of third-year Gynecology and Obstetrics residents after training at a training and surgical experimentation center. Methods: Use of a prospective questionnaire analyzing demographic data, medical residency, skills, competences, and training in a box trainer and in pigs. Results: After the training, there was significant improvement in laparoscopic skills according to the residents (before 1.3/after 2...
October 2016: Einstein
https://www.readbyqxmd.com/read/28073726/breast-cancer-in-women-younger-than-35%C3%A2-years%C3%A2-features-and-outcomes-in-the-breast-unit-at-aristide-le-dantec-teaching-hospital-dakar
#19
M Gueye, S M Kane Gueye, M D Ndiaye Gueye, F Niasse Dia, O Gassama, M Diallo, J C Moreau
The aim of this study was to determine the clinical features and outcomes of women younger than 35 years with breast cancer. This study was performed at Gynecologic and Obstetric Clinic of Dakar Teaching Hospital and retrospectively reviewed the records of all women younger than 35 years seen in our department for histologically proven breast cancer. Data were analyzed with SPSS software (Statistical Package for Social Science) Version 23. Between 2007 and 2015, 62 women with breast cancer met the inclusion criteria and were included...
November 1, 2016: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/28069481/thoracic-endometriosis-syndrome-association-with-pelvic-endometriosis-and-fertility-status
#20
Jessica Ottolina, Francesca De Stefano, Paola Viganò, Paola Ciriaco, Piero Zannini, Massimo Candiani
STUDY OBJECTIVE: Thoracic endometriosis syndrome (TES), characterized mainly by catamenial pneumothorax, represents a relevant condition in patients affected by endometriosis. However, few studies have analyzed this condition under the gynecological point of view, in terms of characteristic of endometriosis and fertility status of affected women. In our study, we evaluate the association between catamenial pneumothorax, pelvic endometriosis and the fertility status of the patients. DESIGN: Retrospective study of 16 patients treated for catamenial pneumothorax between January 2001 and January 2014 at the Thoracic Surgery Department of San Raffaele Scientific Institute...
January 6, 2017: Journal of Minimally Invasive Gynecology
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