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https://www.readbyqxmd.com/read/29240635/the-etiology-of-male-urethral-discharge-in-zimbabwe-results-from-the-zimbabwe-sti-etiology-study
#1
Cornelis A Rietmeijer, More Mungati, Anna Machiha, Owen Mugurungi, Vitalis Kupara, Luanne Rodgers, Peter H Kilmarx, Amy Herman Roloff, Elizabeth Gonese, Beth A Tippett-Barr, Gerald Shambira, David A Lewis, H Hunter Handsfield, Mufuta Tshimanga
INTRODUCTION: Sexually transmitted infections (STIs) are managed syndromically in most developing countries. In Zimbabwe, men presenting with urethral discharge are treated with a single intramuscular dose of kanamycin or ceftriaxone in combination with a week's course of oral doxycycline. This study was designed to assess the current etiology of urethral discharge and other STIs to inform current syndromic management regimens. METHODS: We conducted a study among 200 men with urethral discharge presenting at 6 regionally diverse STI clinics in Zimbabwe...
January 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29237583/high-yield-hiv-testing-facilitated-linkage-to-care-and-prevention-for-female-youth-in-kenya-girls-study-implementation-science-protocol-for-a-priority-population
#2
Irene Inwani, Nok Chhun, Kawango Agot, Charles M Cleland, Jasmine Buttolph, Harsha Thirumurthy, Ann E Kurth
BACKGROUND: Sub-Saharan Africa is the region with the highest HIV burden. Adolescent girls and young women (AGYW) in the age range of 15 to 24 years are twice as likely as their male peers to be infected, making females in sub-Saharan Africa the most at-risk group for HIV infection. It is therefore critical to prioritize access to HIV testing, prevention, and treatment for this vulnerable population. OBJECTIVE: Using an implementation science framework, the purpose of this research protocol was to describe the approaches we propose to optimize engagement of AGYW in both the HIV prevention and care continuum and to determine the recruitment and testing strategies that identify the highest proportion of previously undiagnosed HIV infections...
December 13, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/29236985/how-can-male-rates-of-hiv-testing-be-increased-recommendations-from-a-mixed-methods-study-in-southern-malawi
#3
Amy C Rankin-Williams, Elizabeth M Geoffroy, Ellen S Schell, Andrew M Mguntha
Background: In southern Malawi, 12.8% of adults are HIV positive. Men are less likely to have been tested than women. We investigated men's HIV knowledge and the attitudes, influencers, facilitators and barriers affecting HIV testing. Methods: We conducted an explanatory mixed-methods study with analysis of secondary quantitative data from 425 rural men collected in January 2014 (time 1) and April 2015 (time 2) and qualitative interviews with 50 men in September 2015...
December 11, 2017: International Health
https://www.readbyqxmd.com/read/29236362/implementation-of-repeat-hiv-testing-during-pregnancy-in-southwestern-kenya-progress-and-missed-opportunities
#4
Anna J Rogers, Eliud Akama, Elly Weke, Justin Blackburn, George Owino, Elizabeth A Bukusi, Patrick Oyaro, Zachary A Kwena, Craig R Cohen, Janet M Turan
INTRODUCTION: Repeat HIV testing during the late antenatal period is crucial to identify and initiate treatment for pregnant women with incident HIV infection to prevent perinatal HIV transmission and keep mothers alive. In 2012, the Kenya Ministry of Health adopted international guidelines suggesting that pregnant women be offered retesting three months after an initial negative HIV test. Our objectives were to determine the current rate of antenatal repeat HIV testing; identify successes, missed opportunities and factors associated with retesting; and estimate the incidence of HIV during pregnancy...
December 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29233395/knowledge-attitudes-and-beliefs-regarding-human-immunodeficiency-virus-and-in-home-testing-among-a-regional-sample-of-student-pharmacists
#5
Alvina Tran, Autumn L Stewart, Jordan R Covvey
INTRODUCTION: Pharmacists identify the importance of education on human immunodeficiency virus (HIV); however, research suggests deficits in knowledge regarding recommendations and testing devices. With proper training, student pharmacists can play an important role in counseling patients on the importance of HIV testing and providing instruction on in-home testing. The objective of the study was to assess student pharmacists' knowledge, attitudes and beliefs of HIV and the use of an in-home, over-the-counter HIV testing device...
November 2017: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29232277/scaling-up-hiv-self-testing-in-sub-saharan-africa-a-review-of-technology-policy-and-evidence
#6
Pitchaya P Indravudh, Augustine T Choko, Elizabeth L Corbett
PURPOSE OF REVIEW: HIV self-testing (HIVST) can provide complementary coverage to existing HIV testing services and improve knowledge of status among HIV-infected individuals. This review summarizes the current technology, policy and evidence landscape in sub-Saharan Africa and priorities within a rapidly evolving field. RECENT FINDINGS: HIVST is moving towards scaled implementation, with the release of WHO guidelines, WHO prequalification of the first HIVST product, price reductions of HIVST products and a growing product pipeline...
December 9, 2017: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/29232170/correlates-of-never-testing-for-hiv-among-sexually-active-internet-recruited-gay-bisexual-and-other-men-who-have-sex-with-men-in-the-united-states
#7
Kimberly M Nelson, David W Pantalone, Kristi E Gamarel, Michael P Carey, Jane M Simoni
In the United States, gay, bisexual, and other men who have sex with men (GBMSM) are disproportionately affected by the HIV/AIDS epidemic. Despite great strides in HIV prevention, including biobehavioral HIV prevention strategies such as pre-exposure prophylaxis and treatment as prevention, there has been relatively low uptake of these strategies. The success of biobehavioral prevention strategies requires HIV testing but a subset of GBMSM have never been tested. To optimize prevention efforts, we sought to understand the characteristics of GBMSM who report never testing for HIV...
December 12, 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/29231800/let-s-talk-about-sex-work-in-humanitarian-settings-piloting-a-rights-based-approach-to-working-with-refugee-women-selling-sex-in-kampala
#8
Jennifer S Rosenberg, Denis Bakomeza
Although it is well known that refugees engage in sex work as a form of livelihood, stigma and silence around this issue persist within humanitarian circles. As a result, these refugees' sexual and reproductive health and rights, and related vulnerabilities, remain overlooked. Their protection and health needs, which are significant, often go unmet at the field level. In 2016, the Women's Refugee Commission and Reproductive Health Uganda partnered to pilot a peer-education intervention tailored to meet the needs of refugee women engaged in sex work in Kampala...
December 12, 2017: Reproductive Health Matters
https://www.readbyqxmd.com/read/29230252/evaluation-of-the-utility-of-point-of-care-hiv-testing-on-a-canadian-internal-medicine-inpatient-unit
#9
Lawrence Lau, Beverly Wudel, Eugene Lee, Majid Darraj, Quinlan Richert, Adriana Trajtman, Kim Bresler, Jared Bullard, Ken Kasper, Marissa Becker, Yoav Keynan
Point-of-care (POC) HIV testing has been shown to be an acceptable method for increasing HIV testing uptake. To date, no studies have examined the use of POC testing for routine HIV screening on the medicine inpatient unit. A prospective cross-sectional study was conducted over a three-month period in July, August, and October 2016 to evaluate the prevalence of undiagnosed HIV and the attitudes towards routine POC HIV testing. Patients admitted directly to medicine inpatient teaching units at a tertiary hospital in Winnipeg, Canada, were approached for participation...
2017: Canadian Journal of Infectious Diseases & Medical Microbiology
https://www.readbyqxmd.com/read/29228130/acute-retroviral-syndrome-is-associated-with-high-viral-burden-cd4-depletion-and-immune-activation-in-systemic-and-tissue-compartments
#10
Trevor A Crowell, Donn J Colby, Suteeraporn Pinyakorn, James L K Fletcher, Eugène Kroon, Alexandra Schuetz, Shelly J Krebs, Bonnie M Slike, Louise Leyre, Nicolas Chomont, Linda L Jagodzinski, Irini Sereti, Netanya S Utay, Robin Dewar, Rungsun Rerknimitr, Nitiya Chomchey, Rapee Trichavaroj, Victor G Valcour, Serena Spudich, Nelson L Michael, Merlin L Robb, Nittaya Phanuphak, Jintanat Ananworanich
Background: Many individuals with acute HIV infection (AHI) experience acute retroviral syndrome (ARS), which is associated with adverse long-term clinical outcomes. We characterized clinical, virologic, and immunologic features of ARS and described the impact of early antiretroviral therapy (ART) initiation. Methods: Participants presenting for voluntary HIV testing were enrolled during AHI in Bangkok, Thailand. ARS was defined by ≥3 qualifying signs/symptoms...
December 7, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29224988/linking-hiv-negative-youth-to-prevention-services-in-12-u-s-cities-barriers-and-facilitators-to-implementing-the-hiv-prevention-continuum
#11
Mimi Doll, J Dennis Fortenberry, Denise Roseland, Kathleen McAuliff, Craig M Wilson, Cherrie B Boyer
PURPOSE: Linkage of HIV-negative youth to prevention services is increasingly important with the development of effective pre-exposure prophylaxis that complements behavioral and other prevention-focused interventions. However, effective infrastructure for delivery of prevention services does not exist, leaving many programs to address HIV prevention without data to guide program development/implementation. The objective of this study was to provide a qualitative description of barriers and facilitators of linkage to prevention services among high-risk, HIV-negative youth...
December 7, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/29223964/assessing-stakeholder-perceptions-of-the-acceptability-and-feasibility-of-national-scale-up-for-a-dual-hiv-syphilis-rapid-diagnostic-test-in-malawi
#12
Brandy L Peterson Maddox, Shauntā S Wright, Hazel Namadingo, Virginia B Bowen, Geoffrey A Chipungu, Mary L Kamb
OBJECTIVES: The WHO recommends pregnant women receive both HIV and syphilis testing at their first antenatal care visit, as untreated maternal infections can lead to severe, adverse pregnancy outcomes. One strategy for increasing testing for both HIV and syphilis is the use of point-of-care (rapid) diagnostic tests that are simple, proven effective and inexpensive. In Malawi, pregnant women routinely receive HIV testing, but only 10% are tested for syphilis at their first antenatal care visit...
December 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29220392/safety-and-efficacy-of-the-prepex-device-in-hiv-positive-men-a-single-arm-study-in-zimbabwe
#13
Mufuta Tshimanga, Batsirai Makunike-Chikwinya, Tonderayi Mangwiro, Patricia Tapiwa Gundidza, Pesanai Chatikobo, Vernon Murenje, Amy Herman-Roloff, Peter H Kilmarx, Marrianne Holec, Gerald Gwinji, Owen Mugurungi, Munyaradzi Murwira, Sinokuthemba Xaba, Scott Barnhart, Caryl Feldacker
METHODS: We aimed to determine if the adverse event (AE) rate was non-inferior to an AE rate of 2%, a rate considered the global standard of MC safety. Study procedures, AE definitions, and study staff were unchanged from previous PrePex Zimbabwe trials. After PrePex placement and removal, weekly visits assessed wound healing. Men returned on Day 90. Safety was defined as occurrence of moderate and serious clinical AEs. Efficacy was defined as ability to reach the endpoint of complete circumcision...
2017: PloS One
https://www.readbyqxmd.com/read/29219811/non-targeted-hiv-screening-in-emergency-departments-in-the-netherlands
#14
G P M Luiken, I K Joore, A Taselaar, S C E Schuit, S E Geerlings, A Govers, P P M Rood, J M Prins, B E Nichols, A Verbon, T E M S de Vries-Sluijs
BACKGROUND: In the Netherlands a substantial proportion of newly diagnosed human immunodeficiency virus (HIV) patients present late for care and an estimated 12-34% of people living with HIV are undiagnosed. Linkage to care of these patients is important to decrease HIV transmission and to improve individual patient outcomes. We investigated if non-targeted HIV testing in emergency departments is a useful and cost-effective way to identify these patients. METHODS: In a cross-sectional multicentre study, eligible adult patients who underwent phlebotomy were given an active choice to be additionally tested for HIV...
November 2017: Netherlands Journal of Medicine
https://www.readbyqxmd.com/read/29214408/anticipated-hiv-stigma-and-delays-in-regular-hiv-testing-behaviors-among-sexually-active-young-gay-bisexual-and-other-men-who-have-sex-with-men-and-transgender-women
#15
Kristi E Gamarel, Kimberly M Nelson, Rob Stephenson, Olga J Santiago Rivera, Danielle Chiaramonte, Robin Lin Miller
Young gay, bisexual and other men who have sex with men (YGBMSM) and young transgender women are disproportionately affected by HIV/AIDS. The success of biomedical prevention strategies is predicated on regular HIV testing; however, there has been limited uptake of testing among YGBMSM and young transgender women. Anticipated HIV stigma-expecting rejection as a result of seroconversion- may serve as a significant barrier to testing. A cross-sectional sample of YGBMSM (n = 719, 95.5%) and young transgender women (n = 33, 4...
December 6, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/29210831/correlates-of-linkage-to-hiv-pre-exposure-prophylaxis-prep-among-hiv-testing-clients
#16
Charlene A Flash, Oluwatobi O Adegboyega, Xiaoying Yu, Carmen Avalos, Syundai Johnson, Kenneth H Mayer, Thomas P Giordano
BACKGROUND: Publicly funded HIV testing sites can identify HIV pre-exposure prophylaxis (PrEP) candidates and provide PrEP linkage. SETTING: Harris Health System's HIV clinic, HIV testing program and HIV Prevention Program in Houston, TX, a high HIV incidence city. METHODS: A prospective assessment of individuals ≥18 years old recruited from walk-in HIV testing December, 2013 to April, 2015 included risk assessment, HIV testing and self-administered survey, with follow-up surveys at 6 and 12 months and medical record review...
November 27, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29210826/high-acceptability-and-increased-hiv-testing-frequency-following-introduction-of-hiv-self-testing-and-network-distribution-among-south-african-msm
#17
Sheri A Lippman, Tim Lane, Oscar Rabede, Hailey Gilmore, Yea-Hung Chen, Nkuli Mlotshwa, Kabelo Maleke, Alexander Marr, James A McIntyre
BACKGROUND: South African men-who-have-sex-with-men (MSM) have a high burden of undiagnosed HIV infection and HIV-testing rates incommensurate with their risk. HIV self-testing (HIVST) may increase testing uptake, frequency, and earlier HIV detection and treatment. SETTING: Gert Sibande and Ehlanzeni districts, Mpumalanga Province, South Africa. METHODS: We conducted a longitudinal HIVST study among MSM between June 2015 - May 2017. Overall 127 HIV-negative MSM were provided with up to nine test kits of their choice - oral fluid or blood fingerstick - to use themselves and distribute to their networks...
November 27, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29210185/redemption-of-the-spoiled-identity-the-role-of-hiv-positive-individuals-in-hiv-care-cascade-interventions
#18
Carol S Camlin, Edwin D Charlebois, Elvin Geng, Fred Semitala, Jeanna Wallenta, Monica Getahun, Leatitia Kampiire, Elizabeth A Bukusi, Norton Sang, Dalsone Kwarisiima, Tamara D Clark, Maya L Petersen, Moses R Kamya, Diane V Havlir
INTRODUCTION: The concept of "therapeutic citizenship" has drawn attention to ways in which public testimony, the "story-telling in the public sphere" undertaken by people living with HIV (PLHIV), has shaped the global response to the epidemic. This paper presents qualitative findings from two large studies in eastern Africa that reveal how the advent of population-based HIV testing campaigns and efforts to accelerate antiretroviral "treatment for all" has precipitated a rapidly expanding therapeutic citizenship "project," or social movement...
December 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29208587/hiv-surveillance-among-pregnant-women-attending-antenatal-clinics-evolution-and-current-direction
#19
Jacob Dee, Jesus M Garcia Calleja, Kimberly Marsh, Irum Zaidi, Christopher Murrill, Mahesh Swaminathan
Since the late 1980s, human immunodeficiency virus (HIV) sentinel serosurveillance among pregnant women attending select antenatal clinics (ANCs) based on unlinked anonymous testing (UAT) has provided invaluable information for tracking HIV prevalence and trends and informing global and national HIV models in most countries with generalized HIV epidemics. However, increased coverage of HIV testing, prevention of mother-to-child transmission (PMTCT), and antiretroviral therapy has heightened ethical concerns about UAT...
December 5, 2017: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/29208158/hiv-testing-in-europe-evaluating-the-impact-added-value-relevance-and-usability-of-the-european-centre-for-disease-prevention-and-control-ecdc-s-2010-hiv-testing-guidance
#20
Ann K Sullivan, Ida Sperle, Dorthe Raben, Andrew J Amato-Gauci, Jens Dilling Lundgren, Yazdan Yazdanpanah, Stine Finne Jakobsen, Lara Tavoschi
BACKGROUND: An evaluation of the 2010 ECDC guidance on HIV testing, conducted in October 2015-January 2016, assessed its impact, added value, relevance and usability and the need for updated guidance. METHODS: Data sources were two surveys: one for the primary target audience (health policymakers and decision makers, national programme managers and ECDC official contact points in the European Union/European Economic Area (EU/EEA) countries and one for a broader target audience (clinicians, civil society organisations and international public health agencies); two moderated focus group discussions  (17 participants each); webpage access data; a literature citation review; and an expert consultation (18 participants) to discuss the evaluation findings...
November 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
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