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JOURNAL ARTICLE
Sara Browne, Anya Umlauf, David J Moore, Constance A Benson, Florin Vaida
BACKGROUND: A digital health technology's success or failure depends on how it is received by users. OBJECTIVES: We conducted a user experience (UX) evaluation among persons who used the Food and Drug Administration-approved Digital Health Feedback System incorporating ingestible sensors (ISs) to capture medication adherence, after they were prescribed oral pre-exposure prophylaxis (PrEP) to prevent HIV infection. We performed an association analysis with baseline participant characteristics, to see if "personas" associated with positive or negative UX emerged...
May 3, 2024: JMIR MHealth and UHealth
#2
JOURNAL ARTICLE
Maranda C Ward, Paloma Delgado Setien, Abigail Konopasky, Donaldson F Conserve
The authors report on their development of a National Advisory Board (NAB) to guide a funded project: Two in One: HIV + COVID-19 Screening and Testing Model. This project aimed to improve primary care practitioners' capacity to routinize HIV, PrEP/PEP, and COVID-19 vaccine screenings for all their patients while relying on culturally responsive communication with their minoritized patients. To approach their monumental research and education tasks, they created a NAB, drawing from the literature on advisory boards to (a) promote board member engagement and (b) progress successfully through the six stages suggested for successful advisory boards...
May 9, 2024: Primary Health Care Research & Development
#3
REVIEW
Daniel Ebbs, Max Taricia, Melissa C Funaro, Maggie O'Daniel, Michael Cappello
INTRODUCTION: Point-of-Care Tests (POCTs) are utilized daily in resource abundant regions, however, are limited in the global south, particularly in the prehospital setting. Few studies exist on the use of non-malarial POCTs by Community Health Workers (CHWs). The purpose of this scoping review is to delineate the current diversity in and breadth of POCTs evaluated in the prehospital setting. METHODS: A medical subject heading (MeSH) analysis of known key articles was done by an experienced medical librarian and scoping searches were performed in each database to capture "point of care testing" and "community health workers...
2024: Frontiers in Public Health
#4
JOURNAL ARTICLE
Sophia Zamudio-Haas, Imelda Mahaka, Gwendoline Chapwanya, Megan S Dunbar, Marguerita Lightfoot
BACKGROUND: A persistent treatment gap remains between children and adults living with HIV. The Zvandiri program, developed by Africaid, is one of the few models of differentiated service delivery for children, adolescents, and youth that has been shown to improve outcomes along the HIV care continuum, employing Community Adolescent Treatment Supporters (CATS) to offer peer counseling and patient navigation. Our qualitative study provides an in-depth analysis of the feelings and experiences Zimbabwean youth had following an HIV diagnosis, and the ways that CATS facilitated linkage and retention in care...
2024: Frontiers in Public Health
#5
JOURNAL ARTICLE
Wasiu O Garuba, Adebayo L Adedeji, Kamoru A Adedokun, Olubunmi G Ayelagbe, Idris N Abdullahi, Ibrahim Munirudeen
OBJECTIVE: This study investigates the role of Apoptotic Protease Activating Factor-1 (APAF-1) in CD4+ cell depletion among human immunodeficiency virus (HIV) patients. MATERIALS AND METHODS: This is a cross-sectional study in which 105 participants were enrolled, including 60 confirmed HIV-positive patients and 45 HIV-negative controls. HIV-positive patients were further divided based on CD4+ cell counts: Group 1 (<200), Group 2 (200-499), and Group 3 (≥500)...
2024: International Journal of Health Sciences
#6
JOURNAL ARTICLE
Jacinda Tran, Christine Lee Hathaway, Cara Jill Broshkevitch, Thesla Palanee-Phillips, Ruanne Vanessa Barnabas, Darcy White Rao, Monisha Sharma
INTRODUCTION: Women living with human immunodeficiency virus (WLHIV) face elevated risks of human papillomavirus (HPV) acquisition and cervical cancer (CC). Coverage of CC screening and treatment remains low in low-and-middle-income settings, reflecting resource challenges and loss to follow-up with current strategies. We estimated the health and economic impact of alternative scalable CC screening strategies in KwaZulu-Natal, South Africa, a region with high burden of CC and HIV. METHODS: We parameterized a dynamic compartmental model of HPV and HIV transmission and CC natural history to KwaZulu-Natal...
2024: Frontiers in Oncology
#7
JOURNAL ARTICLE
Phiona E Namale, Linda Boloko, Marcia Vermeulen, Kate A Haigh, Fortuna Bagula, Alexis Maseko, Bianca Sossen, Scott Lee-Jones, Yoliswa Msomi, Helen McIlleron, Ayanda Trevor Mnguni, Thomas Crede, Patryk Szymanski, Jonathan Naude, Sakeena Ebrahim, Yakoob Vallie, Muhammed Shiraz Moosa, Ismail Bandeker, Shakeel Hoosain, Mark P Nicol, Nazlee Samodien, Chad Centner, Wentzel Dowling, Paolo Denti, Freedom Gumedze, Francesca Little, Arifa Parker, Brendon Price, Denzil Schietekat, Bryony Simmons, Andrew Hill, Robert J Wilkinson, Ida Oliphant, Siphokazi Hlungulu, Ivy Apolisi, Monica Toleni, Zimkhitha Asare, Mkanyiseli Kenneth Mpalali, Erica Boshoff, Denise Prinsloo, Francisco Lakay, Abulele Bekiswa, Amanda Jackson, Ashleigh Barnes, Ryan Johnson, Sean Wasserman, Gary Maartens, David Barr, Charlotte Schutz, Graeme Meintjes
BACKGROUND: HIV-associated tuberculosis (TB) contributes disproportionately to global tuberculosis mortality. Patients hospitalised at the time of the diagnosis of HIV-associated disseminated TB are typically severely ill and have a high mortality risk despite initiation of tuberculosis treatment. The objective of the study is to assess the safety and efficacy of both intensified TB treatment (high dose rifampicin plus levofloxacin) and immunomodulation with corticosteroids as interventions to reduce early mortality in hospitalised patients with HIV-associated disseminated TB...
May 8, 2024: Trials
#8
JOURNAL ARTICLE
Florence Bada, Megan E Mansfield, Lillian Okui, Milton Montebatsi, Carlo DiClemente, Roy Tapera, Kaizer Ikgopoleng, Selebaleng Mokonopi, Jessica F Magidson, Eberechukwu Onukwugha, Ndwapi Ndwapi, Seth Himelhoch, Bontle Mbongwe, Man Charurat
BACKGROUND: With expanded and sustained availability of HIV treatment resulting in substantial improvements in life expectancy, the need to address modifiable risk factors associated with leading causes of death among people living with HIV/AIDS (PLWH), such as tobacco smoking, has increased. Tobacco use is highly prevalent among PLWH, especially in southern Africa, where HIV is heavily concentrated, and many people who smoke would like to quit but are unable to do so without assistance...
May 8, 2024: Implementation science communications
#9
JOURNAL ARTICLE
Caroline J Meek, Tiwonge E Mbeya Munkhondya, Mtisunge Mphande, Tapiwa A Tembo, Mike Chitani, Milenka Jean-Baptiste, Dhrutika Vansia, Caroline Kumbuyo, Jiayu Wang, Katherine R Simon, Sarah E Rutstein, Clare Barrington, Maria H Kim, Vivian F Go, Nora E Rosenberg
BACKGROUND: Assisted index case testing (ICT), in which health care workers take an active role in referring at-risk contacts of people living with HIV for HIV testing services, has been widely recognized as an evidence-based intervention with high potential to increase status awareness in people living with HIV. While the available evidence from eastern and southern Africa suggests that assisted ICT can be an effective, efficient, cost-effective, acceptable, and low-risk strategy to implement in the region, it reveals that feasibility barriers to implementation exist...
May 9, 2024: BMC Health Services Research
#10
JOURNAL ARTICLE
Qin Wang, Shane D Gilligan-Steinberg, Wookyeom Kim, Enos C Kline, Ian T Hull, James J Lai, Barry R Lutz
BACKGROUND: Point-of-care (POC) nucleic acid amplification tests (NAAT) can significantly expand testing coverage, which is critical for infectious disease diagnostics and monitoring. The development of various isothermal amplification techniques greatly simplifies NAATs, but the cumbersome nucleic acid extraction step remains a bottleneck for the POC. Alternatively, extraction-free amplification, where crude samples are directly added into the assay, substantially simplifies the workflow...
June 8, 2024: Analytica Chimica Acta
#11
JOURNAL ARTICLE
Peng Wang, Afework Wogayehu, Barbara Bolden, Abdel R Ibrahim, Henry F Raymond
INTRODUCTION: Respondent-driven sampling (RDS) is widely used to sample populations with higher risk of HIV infection for whom no sampling frames exist. However, few studies have been done to assess the reliability of RDS in real world settings. METHODS: We assessed the reliability of naïve RDS samples using five rounds of the National HIV Behavioral Surveillance - People Who Inject Drugs surveys in Newark, New Jersey from 2005 to 2018. Specifically, we compared the distributions of time-insensitive demographic characteristics in temporally adjacent RDS samples with Monte Carlo Two-Sample Kolmogorov-Smirnov Test with 100,000 replicates...
May 6, 2024: Annals of Epidemiology
#12
JOURNAL ARTICLE
Mark A M van den Elshout, Eline S Wijstma, Anders Boyd, Vita W Jongen, Liza Coyer, Peter L Anderson, Udi Davidovich, Henry J C de Vries, Maria Prins, Maarten F Schim van der Loeff, Elske Hoornenborg
BACKGROUND: An increasing number of countries are currently implementing or scaling-up HIV pre-exposure prophylaxis (PrEP) care. With the introduction of PrEP, there was apprehension that condom use would decline and sexually transmitted infections (STIs) would increase. To inform sexual health counselling and STI screening programmes, we aimed to study sexual behaviour and STI incidence among men who have sex with men (MSM) and transgender women who use long-term daily or event-driven PrEP...
May 8, 2024: PLoS Medicine
#13
JOURNAL ARTICLE
Kelsey A Strey, Hannah C Angeles, Vidal M Mendoza, Kelly R Reveles
Introduction: Sexually transmitted infections (STIs) continue to increase in the United States and pregnant patients who acquire STIs are at risk for serious complications. This study estimated the utilization of preventative STI testing among pregnant outpatients on a national scale. Methods : This was a retrospective, cross-sectional study of outpatient visits in the National Ambulatory Medical Care Survey from 2014 to 2016 and 2018 to 2019. All patients reported as pregnant were included to assess STI testing for chlamydia, gonorrhea, hepatitis, and HIV...
May 8, 2024: Journal of Women's Health
#14
JOURNAL ARTICLE
Thomas Yi Teh Lee, Lucas Alves Nemer, Alessandro Ayres Vianna, Yussef Ali Abdouni, Fabrício Luz Cardoso, Antonio Carlos da Costa
OBJECTIVE: To determine the epidemiological profile of patients treated at a philanthropic hospital specialized in Orthopedics and Traumatology, located in a significant urban center, and evaluate the efficacy of initial empirical antibiotic treatment. METHODS: Patients diagnosed with hand infections from September 2020 to September 2022 were included, excluding cases related to open fractures or post-surgical infections and those with incomplete medical records...
2024: Acta Ortopedica Brasileira
#15
JOURNAL ARTICLE
T L Xia, S L Xu, S C Liu, W Xie, Y P Cheng, Y S Guo, J H Lu, Y Zhang
From June 16 to 30, 2023, men who have sex with men (MSM) who had visited Voluntary Counseling Testing (VCT) clinics in the Luohu, Futian and Nanshan districts of Shenzhen were included in this study to analyze their awareness of Mpox and the influencing factors. The mean age of the 262 MSM was (34.78±8.94) years, with the majority being unmarried (75.2%) and 79.0% confirmed to be infected with HIV. The awareness rates for five primary indicators, current status of Mpox, pathogen and source of infection, mode of transmission, population susceptibility, clinical manifestations and treatment were 68...
May 6, 2024: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
#16
JOURNAL ARTICLE
Giorgio Montesi, Matteo Augello, Jacopo Polvere, Giulia Marchetti, Donata Medaglini, Annalisa Ciabattini
BACKGROUND: SARS-CoV-2 mRNA vaccines are highly immunogenic in people living with HIV (PLWH) on effective antiretroviral therapy (ART). However, whether viro-immunologic parameters or other factors affect immune responses to vaccination is debated. This study aimed to develop a machine learning-based model able to predict the humoral response to mRNA vaccines in PLWH and to assess the impact of demographic and clinical variables on antibody production over time. METHODS: Different machine learning algorithms have been compared in the setting of a longitudinal observational study involving 497 PLWH, after primary and booster SARS-CoV-2 mRNA vaccination...
May 7, 2024: Journal of Translational Medicine
#17
JOURNAL ARTICLE
Jemal Ayalew Yimam, Sileshi Luslseged, Jaleta Bulti Tura, Birra Bejiga Bedassa, Feyiso Bati Wariso, Mohammed Ahmed Rameto, Saro Abdella
BACKGROUND: Female sex workers (FSWs) face an elevated risk of developing mental health disorders and alcohol use disorders (AUD), which in turn increase their vulnerability to HIV and other sexually transmitted infections (STIs) and other negative outcomes. To effectively address both of these health issues, it is crucial to understand the shared key determinants underlying these illnesses, which is a substantial knowledge gap in Ethiopia and elsewhere in the world. Therefore, this study aimed to identify the common key determinants of depression and AUD among FSWs in Ethiopia using a bivariate multivariable ordinal logistic model...
May 7, 2024: BMC Psychiatry
#18
JOURNAL ARTICLE
Aaron Plant, Paul Sparks, Deborah Neffa Creech, Ta'Jalik Morgan, Jeffrey D Klausner, Cornelis Rietmeijer, Jorge A Montoya
BACKGROUND: Young Black gay and bisexual men (YBGBM) in the United States face significant disparities in HIV care outcomes. Mobile health (mHealth) interventions have shown promise with improving outcomes for YBGBM across the HIV care continuum. METHODS: We developed an mHealth application using human-centered design (HCD) from 2019-2021 in collaboration with YBGBM living with HIV and with HIV service providers. Our HCD process began with six focus groups with 50 YBGBM and interviews with 12 providers...
May 7, 2024: BMC Public Health
#19
JOURNAL ARTICLE
Kathryn Lurain, Talal El Zarif, Ramya Ramaswami, Amin H Nassar, Elio Adib, Noha Abdel-Wahab, Nikita Chintapally, Claire E Drolen, Tatyana Feldman, Tarek Haykal, Caroline A Nebhan, Swetha Kambhampati, Mingjia Li, Arjun Mittra, Michael Lorentsen, Chul Kim, Alexandra Drakaki, Michael Morse, Douglas B Johnson, Ankit Mangla, Christopher Dittus, Praful Ravi, Robert A Baiocchi, Elizabeth Y Chiao, Paul G Rubinstein, Sarvari V Yellapragada, Ann S LaCasce, Guru P Sonpavde, Abdul Rafeh Naqash, Alex F Herrera
BACKGROUND: Despite a higher risk of classical Hodgkin lymphoma (cHL) in people with HIV and the demonstrated safety and efficacy of PD-1 blockade in cHL, there are limited data on the use of these agents in HIV-associated cHL (HIV-cHL). PATIENTS/METHODS: We retrospectively identified patients with HIV-cHL from the "Cancer Therapy using Checkpoint inhibitors in People with HIV-International (CATCH-IT)" database who received nivolumab or pembrolizumab, alone or in combination with other agents, and reviewed records for demographics, disease characteristics, immune-mediated adverse events (imAEs), and treatment outcomes...
April 5, 2024: Clinical Lymphoma, Myeloma & Leukemia
#20
JOURNAL ARTICLE
Jerome T Galea, Diego H Vasquez, Neil Rupani, Moya B Gordon, Milagros Tapia, Karah Y Greene, Lenka Kolevic, Molly F Franke, Carmen Contreras
BACKGROUND: Adolescents living with HIV are disproportionally affected by depression, which worsens antiretroviral therapy adherence, increases viral load, and doubles the risk of mortality. Because most adolescents living with HIV live in low- and middle-income countries, few receive depression treatment due to a lack of mental health services and specialists in low-resource settings. Chatbot technology, used increasingly in health service delivery, is a promising approach for delivering low-intensity depression care to adolescents living with HIV in resource-constrained settings...
May 7, 2024: JMIR Research Protocols
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