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Long non-coding mRNA

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https://www.readbyqxmd.com/read/28742194/dynamic-regulation-effect-of-long-non-coding-rna-uca1-on-nf-kb-in-hippocampus-of-epilepsy-rats
#1
H-K Wang, H Yan, K Wang, J Wang
OBJECTIVE: We aimed to discuss the mechanism of occurrence and progression of epilepsy through analyzing the expression changes of UCA1 and NF-Kb in temporal hippocampus and UCA1 in peripheral blood in rats with epilepsy induced by lithium chloride-pilocarpine. MATERIALS AND METHODS: The lithium chloride-pilocarpine-induced epilepsy rat model was established; 1, 7, 14, 30, and 60 d after status epilepticus were selected as the time points of research. The expression levels of UCA1 and NF-kB in the hippocampus of rats and UCA1 in peripheral blood were detected and analyzed using quantitative Real-time PCR (qRT-PCR)...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28733557/down-regulation-of-lincrna-p21-contributes-to-gastric-cancer-development-through-hippo-independent-activation-of-yap
#2
Ying Chen, Guoqing Wei, Hongwei Xia, Huangfei Yu, Qiuling Tang, Feng Bi
Long intergenic non-coding RNA p21 (lincRNA-p21), known as the direct transcriptional target of p53, was found down-regulated in several human solid tumors. However, little is known about the role of lincRNA-p21 in gastric cancer. The expression levels of lincRNA-p21 in tissue samples and cell lines were detected by qRT-PCR. MGC-803 and MKN-45 cells were transfected with siRNAs targeting lincRNA-p21 or control siRNAs to determine the effect of reduced lincRNA-p21 expression on tumorigenesis. We also overexpressed lincRNA-p21 in MGC-803 cells...
July 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28722665/mirna-and-lncrna-as-biomarkers-in-cholangiocarcinoma-cca
#3
REVIEW
Bo Zheng, Seogsong Jeong, Yanjing Zhu, Lei Chen, Qiang Xia
The microRNAs are a group of 20 nucleotides-long non-coding RNAs. By binding to the 3'UTR region of target mRNA, microRNAs can perform extensive actions mediating gene expression at post-trancriptional stages. It makes microRNAs serve as very crucial regulators in various biological progress including carcinogenesis. Long non-coding RNAs, however, are a subgroup of RNA with the length of 200 nucleotides. Unlike microRNAs, long non-coding RNAs can form secondary of tertiary domain based on their length. With the ability of directly interacting with DNA, RNA, protein, long non-coding RNAs have promoting or inhibitive functions in gene expression regulation...
July 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28714520/genomic-profiling-of-long-non-coding-rna-and-mrna-expression-associated-with-acquired-temozolomide-resistance-in-glioblastoma-cells
#4
Huijun Zeng, Ningbo Xu, Yanting Liu, Boyang Liu, Zhao Yang, Zhao Fu, Changlin Lian, Hongbo Guo
Temozolomide (TMZ) is an alkylating chemotherapeutic agent widely used in anti-glioma treatment. However, acquired TMZ resistance represents a major clinical challenge that leads to tumor relapse or progress. This study investigated the genomic profiles including long non-coding RNA (lncRNA) and mRNA expression associated with acquired TMZ resistance in glioblastoma (GBM) cells in vitro. The TMZ-resistant (TR) of GBM sub-cell lines were established through repetitive exposure to increasing TMZ concentrations in vitro...
August 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28713985/microarray-expression-profiles-of-long-non-coding-rnas-in-germinal-center-like-diffuse-large-b-cell-lymphoma
#5
Hong-Yu Gao, Bin Wu, Wei Yan, Zi-Mu Gong, Qi Sun, Hui-Han Wang, Wei Yang
Long non-coding RNAs (lncRNAs) are continuously transcribed and are involved in various cellular activities. However, their contributions to the occurrence and development of germinal center B-cell (GCB)-like diffuse large B-cell lymphoma (DLBCL) remain largely unknown. We applied microarray technology to profile the expression of lncRNAs in two different GCB-DLBCL cell lines (OCI-ly1 and OCI-ly19) and normal B lymphocytes. We demonstrated that 21,539 lncRNAs were expressed in all of the samples analyzed...
July 14, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28713971/systematic-analysis-of-lncrnas-mirnas-and-mrnas-for-the-identification-of-biomarkers-for-osteoporosis-in-the-mandible-of-ovariectomized-mice
#6
Lingyu Hao, Jiayao Fu, Yawen Tian, Junhua Wu
Osteoporosis is a complex and multifactorial disease caused by an imbalance between bone formation and resorption. Post‑menopausal women with endogenous estrogen deficiency suffer from systemic bone loss and osteoporosis, and are at high risk of this affecting the jaw bones. MicroRNAs (miRNAs or miRs) have been implicated in the mechanisms of metabolic bone diseases and are expressed at differential levels in alveolar bone following ovariectomy. In the present study, we systematically analyzed the expression profiles of miRNAs, mRNAs and long non‑coding RNA (lncRNAs) in the mandible of ovariectomized (OVX) mice...
July 10, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28713947/microrna-582-promotes-tumorigenesis-by-targeting-phosphatase-and-tensin-homologue-in-colorectal-cancer
#7
Bin Song, Yanbin Long, Dong Liu, Wen Zhang, Chang Liu
A number of studies have implicated that a class of non‑coding RNAs named microRNAs (miRNAs or miRs) is associated with tumorigenesis and have identified miRNAs as promising targets for pharmaceutical intervention. Recently, the deregulated expression of miR‑582 in tumor cells has been reported. However, the exact function of miR‑582 in colorectal cancer (CRC) remains largely unknown. In thi study, we demonstrate that miR‑582 is extensively upregulated in CRC tissues and cell lines. The overexpression of miR‑582 significantly enhanced the proliferation and migration ability of the CRC cells...
July 6, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28713933/mir%C3%A2-146b%C3%A2-5p-promotes-the-neural-conversion-of-pluripotent-stem-cells-by-targeting-smad4
#8
Nianping Zhang, Ying Lyu, Xuebing Pan, Liping Xu, Aiguo Xuan, Xiaosong He, Wandan Huang, Dahong Long
Pluripotent stem cells (PSCs) are regarded as potential sources that provide specific neural cells for cell therapy in some nervous system diseases. However, the mechanisms underlying the neural differentiation of PSCs remain largely unknown. MicroRNAs (miRNAs or miRs) are a class of small non‑pro-tein-coding RNAs that act as critical regulatory molecules in many cellular processes. In this study, we found that miR‑146b‑5p expression was markedly increased following the neural induction of mouse embryonic stem cells (ESCs) or induced PSCs (iPSCs)...
July 11, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28708282/the-mechanism-of-long-non-coding-rna-meg3-for-hepatic-ischemia-reperfusion-mediated-by-mir-34a-nrf2-signaling-pathway
#9
Xinli Huang, Yun Gao, Jianjie Qin, Sen Lu
OBJECTIVE: To investigate the function of MEG3 in hepatic ischemia-reperfusion (HIR) progress, involving its association with the level of miR-34a during hypoxia-induced hypoxia re-oxygenation (H/R) in vitro. METHODS: HIR mice model in vivo was established.MEG3 , miR-34a expression, along with Nrf2 mRNA and protein level were detected in tissues and cells. Serum biochemical parameters (ALT and AST) were assessed in vivo. A potential binding region between MEG3 and miR34a was confirmed by luciferase assays...
July 14, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28706206/identification-of-long-non-coding-rnas-in-two-anthozoan-species-and-their-possible-implications-for-coral-bleaching
#10
Chen Huang, Jean-Étienne R L Morlighem, Jing Cai, Qiwen Liao, Carlos Daniel Perez, Paula Braga Gomes, Min Guo, Gandhi Rádis-Baptista, Simon Ming-Yuen Lee
Long non-coding RNAs (lncRNAs) have been shown to play regulatory roles in a diverse range of biological processes and are associated with the outcomes of various diseases. The majority of studies about lncRNAs focus on model organisms, with lessened investigation in non-model organisms to date. Herein, we have undertaken an investigation on lncRNA in two zoanthids (cnidarian): Protolpalythoa varibilis and Palythoa caribaeorum. A total of 11,206 and 13,240 lncRNAs were detected in P. variabilis and P. caribaeorum transcriptome, respectively...
July 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28704924/lncrnas-and-myc-an-intricate-relationship
#11
REVIEW
Ingram Iaccarino
Long non-coding RNAs (lncRNAs) are emerging as important regulators of gene expression networks, acting either at the transcriptional level, by influencing histone modifications, or at the post-transcriptional level, by controlling mRNA stability and translation. Among the gene expression networks known to influence the process of oncogenic transformation, the one controlled by the proto-oncogene MYC is one of the most frequently deregulated in cancer. In B-cell lymphomas, the MYC gene is subject to chromosomal rearrangements that result in MYC overexpression...
July 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28701520/ligand-recognition-and-helical-stacking-formation-are-intimately-linked-in-the-sam-i-riboswitch-regulatory-mechanism
#12
Anne-Marie Dussault, Audrey Dubé, Frédéric Jacques, Jonathan P Grondin, Daniel Lafontaine
Riboswitches are non-coding mRNA elements that control gene expression by altering their structure upon metabolite binding. Although riboswitch crystal structures provide detailed information about RNA-ligand interactions, little knowledge has been gathered to understand how riboswitches modulate gene expression. Here, we study the molecular recognition mechanism of the S-adenosylmethionine SAM-I riboswitch by characterizing the formation of a helical stacking interaction involving the ligand binding process...
July 12, 2017: RNA
https://www.readbyqxmd.com/read/28699901/transcriptomic-profiling-of-long-non-coding-rnas-in-hepatitis-b-virus-related-hepatocellular-carcinoma
#13
Hongxia Fan, Qiaoge Zhang, Xiaopei Zhao, Ping Lv, Min Liu, Hua Tang
Long non-coding RNAs (lncRNAs) have been reported to be involved in the development and progression of hepatocellular carcinoma (HCC). However, few studies have focus on the dyregulation and the role of lncRNAs in HBV-related HCC. We performed a comprehensive analysis of lncRNAs expression profile in HBV-related HCC tissues samples using deep sequencing. We revealed that a total of 1242 lncRNA transcripts (983 up-regulated and 259 down-regulated) and 1841 mRNA transcripts were significantly differentially expressed in HBV-related HCC patients...
June 30, 2017: Oncotarget
https://www.readbyqxmd.com/read/28687088/canonical-mrna-is-the-exception-rather-than-the-rule
#14
Jun-An Chen, Simon Conn
A report on the Second Aegean International Conference on the Long and the Short of Non-Coding RNAs, held in Heraklion, Greece, 9-14 June 2017.
July 7, 2017: Genome Biology
https://www.readbyqxmd.com/read/28677801/modulation-of-igf2bp1-by-long-non-coding-rna-hcg11-suppresses-apoptosis-of-hepatocellular-carcinoma-cells-via-mapk-signaling-transduction
#15
Yantian Xu, Yuanwen Zheng, Hongyan Liu, Tao Li
Hepatocellular carcinoma (HCC) is a common malignancy of the liver. HCG11 is a member of long non‑coding family, upregulation of which in HCC was proved by our previous study. In the present study, the role of HCG11 in the development of HCC was detected by focusing on the interaction between HCG11 and its target protein insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1). The expression status of HCG11 and IGF2BP1 was first investigated with clinical HCC samples. Then the expressions of HCG11 and IGF2BP1 were both inhibited in the human HCC cell line HepG2 and the cell viability, proliferation, apoptosis and metastasis potential of HepG2 cells were assessed...
July 5, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28677749/long-non%C3%A2-coding-rna-meg3-contributes-to-cisplatin%C3%A2-induced-apoptosis-via-inhibition-of-autophagy-in-human-glioma-cells
#16
Binbin Ma, Zebin Gao, Jiacheng Lou, Hongqiang Zhang, Zhongbo Yuan, Qiong Wu, Xinyu Li, Bo Zhang
Long non-coding RNAs (lncRNAs) function as oncogenes or tumor suppressors, and are involved in mediating tumorigenesis and resistance to chemotherapy by altering the expression of genes at various levels. Accumulating evidence suggests that the maternally expressed gene 3 (MEG3) lncRNA serves an important role in a number of cancers. However, its functional role in mediating cisplatin‑induced apoptosis of glioma cells is unknown. To investigate the role of MEG3, the mRNA levels of MEG3 under cisplatin treatment were investigated by reverse transcription‑quantitative polymerase chain reaction, and the cell viability and apoptosis were examined by MTT assay, and flow cytometry analysis and western blotting, respectively...
September 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28674544/the-interactions-between-the-long-non-coding-rna-nerdl-and-its-target-gene-affect-wood-formation-in-populus-tomentosa
#17
Wan Shi, Mingyang Quan, Qingzhang Du, Deqiang Zhang
Long non-coding RNAs (lncRNAs) are important regulatory factors for plant growth and development, but little is known about the allelic interactions of lncRNAs with mRNA in perennial plants. Here, we analyzed the interaction of the NERD (Needed for RDR2-independent DNA methylation) Populus tomentosa gene PtoNERD with its putative regulator, the lncRNA NERDL (NERD-related lncRNA), which partially overlaps with the promoter region of this gene. Expression analysis in eight tissues showed a positive correlation between NERDL and PtoNERD (r = 0...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28673822/discovery-of-novel-long-non-coding-rnas-induced-by-subgroup-j-avian-leukosis-virus-infection-in-chicken
#18
Lingling Qiu, Zhiteng Li, Guobin Chang, Yulin Bi, Xiangping Liu, Lu Xu, Yang Zhang, Wenming Zhao, Qi Xu, Guohong Chen
Avian leukosis virus subgroup J (ALV-J) is an avian oncogenic retrovirus that has led to severe economic losses in the poultry industry in China in recent decades. Here, using high throughput transcriptome sequencing of HD11 and CEF cells infected with ALV-J, a set of 4804 novel long non-coding transcripts and numerous differentially expressed long non-coding RNAs (lncRNAs) were identified. We also found that they share relatively shorter transcripts and fewer exon numbers compared to mRNA. Correlation analysis suggested that many lncRNAs may activate gene expression in an enhancer-like manner other than through transcriptional regulation...
June 30, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28672980/overexpression-of-long-non-coding-rna-zinc-finger-antisense-1-in-acute-myeloid-leukemia-cell-lines-influences-cell-growth-and-apoptosis
#19
Haifei Guo, Lili Wu, Pu Zhao, Aimei Feng
The association between long non-coding RNA zinc finger antisense 1 (ZFAS1) and acute myeloid leukemia (AML) has not yet been investigated. The present study aimed to assess the potential role of ZFAS1 in AML cell proliferation and apoptosis. The expression of ZFAS1 mRNA in various AML cell lines (HL-60, KG-1, ML-1 and SKNO-1) was measured by reverse transcription-quantitative polymerase chain reaction. The results showed that ZFAS1 expression was increased in all four human AML cell lines compared with the control cell lines (T lymphocytic leukemia or Burkitt's lymphoma)...
July 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28672765/discovery-and-annotation-of-plant-endogenous-target-mimicry-sequences-from-public-transcriptome-libraries-a-case-study-of-prunus-persica
#20
Gökhan Karakülah
Novel transcript discovery through RNA sequencing has substantially improved our understanding of the transcriptome dynamics of biological systems. Endogenous target mimicry (eTM) transcripts, a novel class of regulatory molecules, bind to their target microRNAs (miRNAs) by base pairing and block their biological activity. The objective of this study was to provide a computational analysis framework for the prediction of putative eTM sequences in plants, and as an example, to discover previously un-annotated eTMs in Prunus persica (peach) transcriptome...
June 28, 2017: Journal of Integrative Bioinformatics
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