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Prorenin receptor

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https://www.readbyqxmd.com/read/29751779/essential-role-of-atp6ap2-enrichment-in-caveolae-lipid-raft-microdomains-for-the-induction-of-neuronal-differentiation-of-stem-cells
#1
Nehman Makdissy, Katia Haddad, Jeanne D'arc AlBacha, Diana Chaker, Bassel Ismail, Albert Azar, Ghada Oreibi, David Ayoub, Ibrahim Achkar, Didier Quilliot, Ziad Fajloun
BACKGROUND: The subcellular distribution of prorenin receptor and adaptor protein ATP6AP2 may affect neurogenesis. In this study, we hypothesized that ATP6AP2 expression and subcellular relocalization from caveolae/lipid raft microdomains (CLR-Ms) to intracellular sites may correlate with neuronal differentiation (Neu-Dif) of adipose-derived mesenchymal stem cells (ADSCs). METHODS: Human ADSCs isolated from 24 healthy donors and 24 patients with neurological disorders (ND) were cultured and induced for Neu-Dif...
May 11, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29712882/angiotensin-generation-in-the-brain-a-re-evaluation
#2
REVIEW
Estrellita Uijl, Liwei Ren, A H Jan Danser
The existence of a so-called brain renin-angiotensin system (RAS) is controversial. Given the presence of the blood-brain barrier, angiotensin generation in the brain, if occurring, should depend on local synthesis of renin and angiotensinogen. Yet, although initially brain-selective expression of intracellular renin was reported, data in intracellular renin knockout animals argue against a role for this renin in angiotensin generation. Moreover, renin levels in brain tissue at most represented renin in trapped blood...
April 30, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29667908/the-macula-densa-prorenin-receptor-is-essential-in-renin-release-and-blood-pressure-control
#3
Anne D M Riquier-Brison, Arnold Sipos, Ágnes Prókai, Sarah L Vargas, Ildiko Toma, Elliott J Meer, Karie G Villanueva, Jennifer C M Chen, Georgina Gyarmati, Christopher Yih, Elaine Tang, Bahram Nadim, Sujith Pendekanti, Ingrid M Garrelds, Genevieve Nguyen, A H Jan Danser, Janos Peti-Peterdi
The prorenin receptor (PRR) was originally proposed to be a member of the renin-angiotensin system (RAS), however recent work questioned their association. The present paper describes a functional link between the PRR and RAS in the renal juxtaglomerular apparatus (JGA), a classic anatomical site of the RAS. PRR expression was found in the sensory cells of the JGA, the macula densa (MD), and immunohistochemistry localized PRR to the MD basolateral cell membrane in mouse, rat, and human kidneys. MD cell PRR activation led to MAP kinase ERK1/2 signaling and stimulation of PGE2 release, the classic pathway of MD-mediated renin release...
April 18, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29611334/conditional-ablation-of-the-prorenin-receptor-in-nephron-progenitor-cells-results-in-developmental-programming-of-hypertension
#4
Renfang Song, Laura Kidd, Adam Janssen, Ihor V Yosypiv
Nephron induction during kidney development is driven by reciprocal interactions between progenitor cells (NPCs) of the cap mesenchyme (CM) and the ureteric bud (UB). The prorenin receptor (PRR) is a receptor for renin and prorenin, and an accessory subunit of the vacuolar proton pump V-ATPase. Previously, we demonstrated that conditional ablation of the PRR in Six2+ NPCs in mice (Six2PRR -/- ) causes early neonatal death. Here, we identified genes that are regulated by PRR in Six2+ NPCs FACS-isolated from Six2PRR -/- and control kidneys on embryonic day E15...
April 2018: Physiological Reports
https://www.readbyqxmd.com/read/29575757/-pro-renin-receptor-involvement-in-diabetic-retinopathy-and-development-of-molecular-targeted-therapy
#5
Atsuhiro Kanda, Susumu Ishida
The renin-angiotensin system (RAS), a crucial regulator of systemic blood pressure (circulatory RAS), plays distinct roles in pathological angiogenesis and inflammation in various organs (tissue RAS) such as diabetic microvascular complications. Using ocular clinical samples and animal disease models, we elucidated molecular mechanisms in which tissue RAS excites the expression of vascular endothelial growth factor (VEGF)-A responsible for retinal inflammation and angiogenesis, the two major pathological events in diabetic retinopathy (DR)...
March 25, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29540174/prenatal-dexamethasone-and-postnatal-high-fat-diet-have-a-synergistic-effect-of-elevating-blood-pressure-through-a-distinct-programming-mechanism-of-systemic-and-adipose-renin-angiotensin-systems
#6
Hong-Ren Yu, You-Lin Tain, Mao-Meng Tiao, Chih-Cheng Chen, Jiunn-Ming Sheen, I-Chun Lin, Shih-Wen Li, Ching-Chou Tsai, Yu-Ju Lin, Kai-Sheng Hsieh, Li-Tung Huang
BACKGROUND: Hypertension may result from high-fat (HF) diet induced-obesity and overexposure to glucocorticoids in utero. Recent studies demonstrated the potent contribution of adipose tissue's renin-angiotensin system (RAS) to systemic RAS, which plays a key role in regulating blood pressure (BP). In this study, we investigated the effects of prenatal dexamethasone (DEX) exposure and postnatal HF diet on RAS of adipose tissue. METHODS: RAS and BP of 6-month old rats exposed to prenatal DEX and/or postnatal HF diet were examined...
March 14, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29496794/revisiting-old-friends-sortilin-1-low-density-lipoprotein-receptor-and-prorenin-receptor-as-modulators-of-lipoprotein-and-energy-metabolism
#7
EDITORIAL
Alanna Strong
No abstract text is available yet for this article.
March 2, 2018: Circulation Research
https://www.readbyqxmd.com/read/29407880/the-protective-effect-of-resveratrol-on-vascular-aging-by-modulation-of-the-renin-angiotensin-system
#8
Eun Nim Kim, Min Young Kim, Ji Hee Lim, Yaeni Kim, Seok Joon Shin, Cheol Whee Park, Yong-Soo Kim, Yoon Sik Chang, Hye Eun Yoon, Bum Soon Choi
BACKGROUND AND AIMS: This study evaluated the effects of resveratrol on arterial aging and the renin-angiotensin system (RAS) in mice and vascular smooth muscle cells (VSMCs). METHODS: Aging mice were divided into control and resveratrol groups. Histological changes, inflammation, oxidative stress, RAS components, and the expression of AMP-activated protein kinase (AMPK), silent information regulator T1 (SIRT1), peroxisome proliferator-activated receptor-γ co-activator 1α (PGC-1α), and anti-oxidative enzymes was measured in thoracic aortas of 24-month-old mice...
March 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29367076/angiotensin-peptides-in-the-non-gravid-uterus-paracrine-actions-beyond-circulation
#9
REVIEW
Maíra Casalechi, Cynthia Dela Cruz, Luiza C Lima, Luciana P Maciel, Virgínia M Pereira, Fernando M Reis
The renin-angiotensin system (RAS) involves a complex network of precursors, peptides, enzymes and receptors comprising a systemic (endocrine) and a local (paracrine/autocrine) system. The local RAS plays important roles in tissue modulation and may operate independently of or in close interaction with the circulatory RAS, acting in a complementary fashion. Angiotensin (Ang) II, its receptor AT1 and Ang-(1-7) expression in the endometrium vary with menstrual cycle, and stromal cell decidualization in vitro is accompanied by local synthesis of angiotensinogen and prorenin...
March 2018: Peptides
https://www.readbyqxmd.com/read/29350998/overexpression-of-the-neuronal-human-pro-renin-receptor-mediates-angiotensin-ii-independent-blood-pressure-regulation-in-the-central-nervous-system
#10
Hua Peng, Dane D Jensen, Wencheng Li, Michelle N Sullivan, Sophie A Buller, Caleb J Worker, Silvana G Cooper, Shiqi Zheng, Scott Earley, Curt D Sigmund, Yumei Feng
Despite advances in antihypertensive therapeutics, at least 15-20% of hypertensive patients have resistant hypertension through mechanisms that remain poorly understood. In this study, we provide a new mechanism for the regulation of blood pressure (BP) in the central nervous system (CNS) by the (pro)renin receptor (PRR), a recently identified component of the renin-angiotensin system that mediates ANG II formation in the CNS. Although PRR also mediates ANG II-independent signaling, the importance of these pathways in BP regulation is unknown...
March 1, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29346132/enzymatic-sources-and-physio-pathological-functions-of-soluble-pro-renin-receptor
#11
Qing Zhu, Tianxin Yang
PURPOSE OF REVIEW: (Pro)renin receptor (PRR) belongs to type I transmembrane receptor family and binds both prorenin and renin, representing a potential regulator of the activity of the renin-angiotensin system. Soluble form of PRR (sPRR) is generated by intracellular protease-mediated cleavage of full-length PRR. The purpose of this review is to highlight recent advances in understanding the mechanisms of action and production of sPRR. RECENT FINDINGS: It has recently been demonstrated that site-1-protease (S1P) plays a dominant role in the generation of sPRR...
March 2018: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/29240802/systemic-factors-related-to-soluble-pro-renin-receptor-in-plasma-of-patients-with-proliferative-diabetic-retinopathy
#12
Keitaro Hase, Atsuhiro Kanda, Ikuyo Hirose, Kousuke Noda, Susumu Ishida
(Pro)renin receptor [(P)RR], a new component of the tissue renin-angiotensin system (RAS), plays a crucial role in inflammation and angiogenesis in the eye, thus contributing to the development of proliferative diabetic retinopathy (PDR). In this study, we investigated systemic factors related to plasma levels of soluble form of (P)RR [s(P)RR] in patients with PDR. Twenty type II diabetic patients with PDR and 20 age-matched, non-diabetic patients with idiopathic macular diseases were enrolled, and plasma levels of various molecules were measured by enzyme-linked immunosorbent assays...
2017: PloS One
https://www.readbyqxmd.com/read/29220406/excessively-low-salt-diet-damages-the-heart-through-activation-of-cardiac-pro-renin-receptor-renin-angiotensin-aldosterone-and-sympatho-adrenal-systems-in-spontaneously-hypertensive-rats
#13
Chihiro Okamoto, Yuka Hayakawa, Takuma Aoyama, Hisaaki Komaki, Shingo Minatoguchi, Masamitsu Iwasa, Yoshihisa Yamada, Hiromitsu Kanamori, Masanori Kawasaki, Kazuhiko Nishigaki, Atsushi Mikami, Shinya Minatoguchi
OBJECTIVE: A high salt intake causes hypertension and leads to cardiovascular disease. Therefore, a low salt diet is now recommended to prevent hypertension and cardiovascular disease. However, it is still unknown whether an excessively low salt diet is beneficial or harmful for the heart. METHODS: Wistar Kyoto rats (WKYs) and spontaneously hypertensive rats (SHRs) received normal salt chow (0.9% salt diet) and excessively low salt chow (0.01% salt diet referred to as saltless diet) for 8 weeks from 8 to 16 weeks of age...
2017: PloS One
https://www.readbyqxmd.com/read/29102794/-pro-renin-receptor-expression-in-myocardial-infarction-in-transgenic-mice-expressing-rat-tonin
#14
Amanda A Ribeiro, Rebeca Padrao Amorim, Zaira J Palomino, Mércia de Paula Lima, Ivana Cinthya Moraes-Silva, Leandro Ezequiel Souza, Jorge Luiz Pesquero, Maria Claudia Irigoyen, Dulce E Casarini
The (pro)renin receptor [(P)RR] has been implicated as a renin/prorenin receptor, and plays a role in local renin angiotensin system activation. Our goal was to investigate whether a transgenic mouse that expresses rat tonin [TGM'(rTon)] can regulate (P)RR mRNA levels. Control (C) and TGM'(rTon) animals were subdivided into the C sham, C MI, TGM'(rTon) sham, and TGM'(rTon) MI groups. The levels of tonin, (P)RR, and renin were determined using RT-PCR mRNA. Tonin activity as determined by RIE was significantly increased in the TGM'(rTon) sham group as compared to the C sham group in the atrium (AT) and right ventricle (RV), respectively...
March 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29101170/the-prorenin-receptor-in-the-cardiovascular-system-and-beyond
#15
Matthew Hennrikus, Alexis A Gonzalez, Minolfa C Prieto
Since the prorenin receptor (PRR) was first reported, its physiological role in many cellular processes has been under intense scrutiny. The PRR is currently recognized as a multifunctional receptor with major roles as an accessory protein of the vacuolar-type H+ -ATPase and as an intermediary in the Wnt signaling pathway. As a member of the renin-angiotensin system (RAS), the PRR has demonstrated to be of relevance in cardiovascular diseases (CVD) because it can activate prorenin and enhance the enzymatic activity of renin, thus promoting angiotensin II formation...
February 1, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29056916/inhibition-of-pro-renin-receptor-contributes-to-renoprotective-effects-of-angiotensin-ii-type-1-receptor-blockade-in-diabetic-nephropathy
#16
Lin Zhang, Xiao-Fei An, Xin Ruan, Dong-Dong Huang, Li Zhou, Hong Xue, Li-Min Lu, Ming He
Aims: Renal renin-angiotensin system (RAS) plays a pivotal role in the development of diabetic nephropathy (DN). Angiotensin II (Ang II) type 1 receptor (AT1 R) blockade elevates (pro)renin, which may bind to (pro)renin receptor (PRR) and exert receptor-mediated, angiotensin-independent profibrotic effects. We therefore investigated whether PRR activation leads to the limited anti-fibrotic effects of AT1 R blockade on DN, and whether PRR inhibition might ameliorate progression of DN. Methods: To address the issue, the expression of RAS components was tested in different stages of streptozotocin (STZ)-induced diabetic rats (6, 12, and 24 weeks) and 6-week AT1 R blockade (losartan) treated diabetic rats...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29050747/soluble-pro-renin-receptor-in-preeclampsia-and-diabetic-pregnancies
#17
Meryam Sugulle, Harald Heidecke, Ulrike Maschke, Florian Herse, A H Jan Danser, Dominik N Mueller, Anne Cathrine Staff, Ralf Dechend
Women with preexisting or gestational diabetes mellitus have an increased risk for developing preeclampsia. Diabetes and pregnancy are both characterized by very high prorenin levels and renin-angiotensin system activation. Prorenin bound to the (pro)renin receptor has enzymatic activity. We hypothesized that soluble (pro)renin receptor levels are elevated in high-risk pregnancies. Third trimester maternal blood samples from complicated pregnancies (n = 165), (preeclampsia [n = 76], diabetes mellitus [type I diabetes, n = 35; type II diabetes, n = 11; gestational diabetes mellitus, n = 43]), and healthy pregnancies (n = 49) were analyzed for prorenin, renin, and soluble (pro)renin receptor...
October 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/28980339/prorenin-receptor-mediates-inflammation-in-renal-ischemia
#18
Syed S Quadri, Silas Culver, Helmy M Siragy
We hypothesized that PRR contributes to renal inflammation in the 2-kidney, 1-clip (2K1C) renal ischaemia model. Male Sprague-Dawley rats were fed normal sodium diet. Blood pressure (BP) was obtained on days 0 and 28 after left renal artery clipping that reduced renal blood flow by 40%. Renal expression of TNF-α, COX-2, NF-κB, IL-1β, MCP-1 and collagen type I were assessed in sham and 2K1C rats with or without left renal administration of scramble or PRR shRNA. At baseline, there were no differences in BP...
February 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28918839/prostaglandin-e-2-induces-prorenin-dependent-activation-of-pro-renin-receptor-and-upregulation-of-cyclooxygenase-2-in-collecting-duct-cells
#19
Nicolás Salinas-Parra, Cristian Reyes-Martínez, Minolfa C Prieto, Alexis A Gonzalez
BACKGROUND: Prostaglandin E2 (PGE2 ) regulates renin expression in renal juxtaglomerular cells. PGE2 acts through E-prostanoid (EP) receptors in the renal collecting duct (CD) to regulate sodium and water balance. CD cells express EP1 and EP4, which are linked to protein kinase C (PKC) and PKA downstream pathways, respectively. Previous studies showed that the presence of renin in the CD, and that of PKC and PKA pathways, activate its expression. The (pro)renin receptor (PRR) is also expressed in CD cells, and its activation enhances cyclooxygenase-2 (COX-2) through extracellular signal-regulated kinase (ERK)...
September 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28864001/associations-between-the-levels-of-soluble-pro-renin-receptor-in-maternal-and-umbilical-cord-blood-and-hypertensive-disorder-of-pregnancy
#20
Yukiko Mikami, Yasushi Takai, Tatsuya Narita, Sumiko Era, Yoshihisa Ono, Masahiro Saitoh, Kazunori Baba, Kikumi Matsuoka, Hiroyuki Seki
INTRODUCTION: The prorenin (PR) receptor [(P)RR] contributes to the regulation of the tissue renin-angiotensin system (RAS) and Wnt signaling, which is involved in embryogenesis and the pathological progression of malignant tumors and diabetes mellitus. Placental (P)RR is significantly upregulated in placental tissues from preeclamptic women. However, because it cannot be examined during pregnancy, the chronological relationship between the acceleration of tissue RAS and the disease state of hypertensive disorder of pregnancy (HDP) has not been reported...
September 2017: Placenta
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