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https://www.readbyqxmd.com/read/28228098/anti-obesity-effect-of-ethanolic-extract-from-cosmos-caudatus-kunth-leaf-in-lean-rats-fed-a-high-fat-diet
#1
Hafeedza Abdul Rahman, Najla Gooda Sahib, Nazamid Saari, Faridah Abas, Amin Ismail, Muhammad Waseem Mumtaz, Azizah Abdul Hamid
BACKGROUND: Obesity is a major health concern both in developed and developing countries. The use of herbal medicines became the subject of interest for the management of obesity due to its natural origin, cost effectiveness and minimal side effects. The present study aimed at investigating anti-obesity potential of ethanolic extract from Cosmos caudatus Kunth leaf (EECCL). METHODS: In this study, the rats were randomly divided into six groups i.e., (1) Normal Diet (ND); (2) Normal Diet and 175 mg/kgBW of EECCL (ND + 175 mg/kgBW); (3) Normal Diet and 350 mg/kgBW of EECCL (ND + 350 mg/kgBW); (4) High Fat Diet (HFD); (5) High Fat Diet and 175 mg/kgBW of EECCL (HFD + 175 mg/kgBW); (6) High Fat Diet and 350 mg/kgBW of EECCL (HFD + 350 mg/kgBW)...
February 22, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28212930/molecular-recognition-between-pancreatic-lipase-and-natural-and-synthetic-inhibitors
#2
Martiniano Bello, Lucia Basilio-Antonio, Jonathan Fragoso-Vázquez, Anaguiven Avalos-Soriano, José Correa-Basurto
Pancreatic lipase (PL) is a primary lipase critical for triacylglyceride digestion in humans and is considered as a promising target for the treatment of obesity. Although the current synthetic drugs available for treating obesity have been demonstrated to be effective in inhibiting PL, their prolonged usage results in severe side effects. Based on this argument, in this study, we evaluated the structural and energetic features linked to molecular recognition between two well-known PL inhibitors, orlistat (ORL, synthetic inhibitor) and (-)-epigallocatechin gallate (EGCG, natural inhibitor) and PL through molecular dynamics simulations and free energy calculations of ORL and EGCG at the PL binding site when it is isolated (PL) from the heterodimer complex, forming the heterodimer complex with colipase (PLCL) and lacking structural calcium...
February 16, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28209193/up601-a-standardized-botanical-composition-composed-of-morus-alba-yerba-mate-and-magnolia-officinalis-for-weight-loss
#3
Mesfin Yimam, Ping Jiao, Mei Hong, Lidia Brownell, Young-Chul Lee, Eu-Jin Hyun, Hyun-Jin Kim, Jeong-Bum Nam, Mi-Ran Kim, Qi Jia
BACKGROUND: The prevalence of obesity is surging in an alarming rate all over the world. Pharmaceutical drugs are considered potential adjunctive therapy to lifestyle modification. However, for most, besides being too expensive, their long term usages are hindered by their severe adverse effects. Here we describe the effect of UP601, a standardized blend of extracts from Morus alba, Yerba mate and Magnolia officinalis, in modulating a number of obesity-related phenotypic and biochemical markers in a high-fat high-fructose (HFF)-induced C57BL/6J mouse model of obesity...
February 16, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28193229/involvement-of-fatty-acid-synthase-in-dengue-virus-infection
#4
Natthida Tongluan, Suwipa Ramphan, Phitchayapak Wintachai, Janthima Jaresitthikunchai, Sarawut Khongwichit, Nitwara Wikan, Supoth Rajakam, Sutee Yoksan, Nuttaporn Wongsiriroj, Sittiruk Roytrakul, Duncan R Smith
BACKGROUND: The mosquito transmitted Dengue virus (DENV) remains a significant public health problem in many tropical and subtropical countries. Increasing evidence has suggested that during the infection process cellular lipids play important roles at several stages of the replication cycle. This study sought to characterize the changes in lipid metabolism gene expression and investigated the role of one enzyme, fatty acid synthase, in DENV infection. METHODS: Transcriptional profiles of genes associated with lipid metabolism were evaluated by real-time PCR after infection of different cell lines (HepG2 and HEK293T/17) and with different DENVs (laboratory adapted and low passage)...
February 13, 2017: Virology Journal
https://www.readbyqxmd.com/read/28191026/supplementation-with-dairy-calcium-and-or-flaxseed-fibers-in-conjunction-with-orlistat-augments-fecal-fat-excretion-without-altering-ratings-of-gastrointestinal-comfort
#5
Mette Kristensen, Signe Rømer Juul, Karina Vejrum Sørensen, Janne Kunchel Lorenzen, Arne Astrup
BACKGROUND: Orlistat is a lipase inhibitor which reduced absorption of dietary fat by ~30% thereby inducing a weight loss; however, side effects occur as a consequence of increased colonic fat content. To test the hypothesis that most gastrointestinal side events induced by treatment with orlistat could be prevented/ameliorated by concomitant use of natural dietary components, flaxseed fiber (FF) and/or dairy calcium (Ca), binding liquid fats to more solid complexes. METHODS: A randomized controlled dietary intervention study...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/28190628/reporting-bias-inflates-the-reputation-of-medical-treatments-a-comparison-of-outcomes-in-clinical-trials-and-online-product-reviews
#6
Mícheál de Barra
OBJECTIVES: People often hold unduly positive expectations about the outcomes of medicines and other healthcare products. Here the following explanation is tested: people who have a positive outcome tend to tell more people about their disease/treatment than people with poor or average outcomes. Akin to the file drawer problem in science, this systematically and positively distorts the information available to others. METHOD: If people with good treatment outcomes are more inclined to tell others, then they should also be more inclined to write online medical product reviews...
February 7, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28177280/orlistat-and-acute-kidney-injury-a-case-report
#7
Ertugrul Erken, Orcun Altunoren, Ozkan Gungor
No abstract text is available yet for this article.
March 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/28153426/factors-affecting-gastrointestinal-absorption-of-levothyroxine-a-review
#8
REVIEW
Marko Skelin, Tomo Lucijanić, Daniela Amidžić Klarić, Arnes Rešić, Miro Bakula, Ana-Marija Liberati-Čizmek, Hossein Gharib, Dario Rahelić
PURPOSE: Levothyroxine (LT4) is a drug with a narrow therapeutic index, applied in small amounts (micrograms), which makes interactions in the absorption phase clinically significant. The main aim of this article was to review and present the latest information on factors that affect the gastrointestinal absorption of this drug. METHODS: Relevant data were collected by using the MEDLINE, PubMed, EMBASE, Web of Science, Science Direct, and Scopus databases with the key words levothyroxine and absorption...
January 30, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28152617/further-brominated-polyacetylenes-with-pancreatic-lipase-inhibitory-activity-from-chinese-marine-sponge-xestospongia-testudinaria
#9
Min Yang, Lin-Fu Liang, Ting Wang, He-Yao Wang, Hai-Li Liu, Yue-Wei Guo
A new brominated polyacetylene, xestonariene I (1), along with three known related analogues (2-4), was obtained from Chinese marine sponge Xestospongia testudinaria. Its structure was determined on the basis of detailed spectroscopic analysis and by comparison with literature data. Compound 4 exhibited significant inhibitory activity against pancreatic lipase, which plays a key role in preventing obesity, with an IC50 value of 0.61 μM, being comparable to that of the positive control orlistat (IC50 = 0...
February 2, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28106756/inhibitory-effects-of-constituents-from-the-aerial-parts-of-rosmarinus-officinalis-l-on-triglyceride-accumulation
#10
Jian Li, Tiwalade Adegoke Adelakun, Sijian Wang, Jingya Ruan, Shengcai Yang, Xiaoxia Li, Yi Zhang, Tao Wang
Sixteen flavonoids (1-16) including two new ones, named officinoflavonosides A (1) and B (2) were obtained from the aerial parts of Rosmarinus officinalis. Among the known ones, 6, 10, and 13 were isolated from the rosmarinus genus for the first time. Their structures were elucidated by chemical and spectroscopic methods. Moreover, the effects on sodium oleate-induced triglyceride accumulation (TG) in HepG2 cells of the above-mentioned compounds and 16 other isolates (17-32) reported previously to have been obtained in the plant were analyzed...
January 17, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28097013/randomised-double-blind-clinical-investigation-to-compare-orlistat-60-milligram-and-a-customized-polyglucosamine-two-treatment-methods-for-the-management-of-overweight-and-obesity
#11
Manfred Stoll, Norman Bitterlich, Umberto Cornelli
BACKGROUND: The efficacy of a non-prescription drug to support weight loss programs has yet to be compared. This clinical trial investigates the comparability of orlistat 60 milligram (mg) and polyglucosamine. METHODS: Sixty-four overweight or obese subjects were included in a two-center double-blind study. One center was in Germany [center 1] and the other was in Italy [center 2]. The subjects (26 in center 1 and 38 in center 2) were recommended to follow a calorie deficit of about 2000 kilojoules/day and to increase their physical activity to 3 metabolic equivalent hours (MET h)/day...
2017: BMC Obesity
https://www.readbyqxmd.com/read/28054388/good-outcome-of-living-donor-liver-transplantation-in-drug-induced-acute-liver-failure-a-single-centre-experience
#12
Narendra Singh Choudhary, Sanjiv Saigal, Neeraj Saraf, Amit Rastogi, Sanjay Goja, Prashant Bhangui, Vijay Vohra, Deepak Govil, Arvinder S Soin
INTRODUCTION: Drug induced acute liver failure (ALF) is associated with high mortality. There is limited literature on results of living donor liver transplantation (LDLT). MATERIAL AND METHODS: The study was conducted at a tertiary care centre in North India. All patients who received LDLT for drug induced ALF were included. The data is shown as median (IQR). RESULTS: A total of 18 patients (15 females and 3 males), aged 34(25-45) years, underwent LDLT for DILI related ALF...
January 5, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28043634/mycobacterial-excretory-secretory-31-protein-with-serine-protease-and-lipase-activities-an-immunogen-and-drug-target-against-tuberculosis-infection
#13
Bhaskar C Harinath
OBJECTIVE/BACKGROUND: Tuberculosis (TB) has been declared as a global emergency by the World Health Organization in 1993 and still remains one of the world's biggest threats. Worldwide, 9.6 million people have been estimated to have fallen ill with TB in 2014: 5.4 million men, 3.2 million women, and 1.0 million children. To reduce this burden, detection and treatment gaps must be addressed and new tools developed (Global TB report 2015). METHODS: Seroreactivity of the purified excretory secretory (ES) antigens ES-31, ES-43, ES-41, and ES-6 have been assessed in pulmonary TB (fresh, relapse, chronic, and latent), extrapulmonary TB, and in human immunodeficiency virus-TB coinfection...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/27979523/re-acute-oxalate-nephropathy-associated-with-orlistat
#14
Dean G Assimos
No abstract text is available yet for this article.
January 2017: Journal of Urology
https://www.readbyqxmd.com/read/27941599/marine-algae-as-a-potential-source-for-anti-obesity-agents
#15
REVIEW
Chu Wan-Loy, Phang Siew-Moi
Obesity is a major epidemic that poses a worldwide threat to human health, as it is also associated with metabolic syndrome, type 2 diabetes and cardiovascular disease. Therapeutic intervention through weight loss drugs, accompanied by diet and exercise, is one of the options for the treatment and management of obesity. However, the only approved anti-obesity drug currently available in the market is orlistat, a synthetic inhibitor of pancreatic lipase. Other anti-obesity drugs are still being evaluated at different stages of clinical trials, while some have been withdrawn due to their severe adverse effects...
December 7, 2016: Marine Drugs
https://www.readbyqxmd.com/read/27918556/effects-of-fatty-acid-synthase-inhibitors-on-lymphatic-vessels-an-in-vitro-and-in-vivo-study-in-a-melanoma-model
#16
Débora C Bastos, Jenny Paupert, Catherine Maillard, Fabiana Seguin, Marco A Carvalho, Michelle Agostini, Ricardo D Coletta, Agnès Noël, Edgard Graner
Fatty acid synthase (FASN) is responsible for the endogenous production of fatty acids from acetyl-CoA and malonyl-CoA. Its overexpression is associated with poor prognosis in human cancers including melanomas. Our group has previously shown that the inhibition of FASN with orlistat reduces spontaneous lymphatic metastasis in experimental B16-F10 melanomas, which is a consequence, at least in part, of the reduction of proliferation and induction of apoptosis. Here, we sought to investigate the effects of pharmacological FASN inhibition on lymphatic vessels by using cell culture and mouse models...
December 5, 2016: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/27899001/drug-interventions-for-the-treatment-of-obesity-in-children-and-adolescents
#17
REVIEW
Emma Mead, Greg Atkinson, Bernd Richter, Maria-Inti Metzendorf, Louise Baur, Nicholas Finer, Eva Corpeleijn, Claire O'Malley, Louisa J Ells
BACKGROUND: Child and adolescent obesity has increased globally, and can be associated with significant short- and long-term health consequences. OBJECTIVES: To assess the efficacy of drug interventions for the treatment of obesity in children and adolescents. SEARCH METHODS: We searched CENTRAL, MEDLINE, Embase, PubMed (subsets not available on Ovid), LILACS as well as the trial registers ICTRP (WHO) and ClinicalTrials.gov. Searches were undertaken from inception to March 2016...
November 29, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27872792/porcine-pancreatic-lipase-inhibitory-agent-isolated-from-medicinal-herb-and-inhibition-kinetics-of-extracts-from-eleusine-indica-l-gaertner
#18
Siew Ling Ong, Siau Hui Mah, How Yee Lai
Eleusine indica (Linnaeus) Gaertner is a traditional herb known to be depurative, febrifuge, and diuretic and has been reported with the highest inhibitory activity against porcine pancreatic lipase (PPL) among thirty two plants screened in an earlier study. This study aims to isolate and identify the active components that may possess high potential as an antiobesity agent. Of the screened solvent fractions of E. indica, hexane fraction showed the highest inhibitory activity of 27.01 ± 5.68% at 100 μg/mL...
2016: Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27845741/cst-an-herbal-formula-exerts-anti-obesity-effects-through-brain-gut-adipose-tissue-axis-modulation-in-high-fat-diet-fed-mice
#19
AbuZar Ansari, Shambhunath Bose, Mukesh Kumar Yadav, Jing-Hua Wang, Yun-Kyung Song, Seong-Gyu Ko, Hojun Kim
The brain, gut, and adipose tissue interact to control metabolic pathways, and impairment in the brain-gut-adipose axis can lead to metabolic disorders, including obesity. Chowiseungcheng-tang (CST), a herbal formulation, is frequently used to treat metabolic disorders. Here, we investigated the anti-obesity effect of CST and its link with brain-gut-adipose axis using C57BL/6J mice as a model. The animals were provided with a normal research diet (NRD) or high-fat diet (HFD) in absence or presence of CST or orlistat (ORL) for 12 weeks...
November 11, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27808050/-pharmacotherapy-for-obesity
#20
Jens Meldgaard Bruun
Obesity is a chronic condition, which is why pharmacotherapy can be considered, if lifestyle modification (hypocaloric diet/exercise) does not result in a weight loss of at least 5%. Pharmacotherapy is indicated, if an individual has a BMI > 30 kg/m(2) or a BMI > 27 kg/m(2) and concomitant disease (e.g. Type 2 diabetes), and can be liraglutide (3 mg) or orlistat (120 mg/60 mg). Choice of treatment must be based on patient preferences and clinical situation, side effects, contraindications and financial considerations...
October 31, 2016: Ugeskrift for Laeger
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