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https://www.readbyqxmd.com/read/29148546/-chronic-kidney-disease-the-relevant-information-for-an-occupational-physician
#1
REVIEW
Marcin Renke, Jacek Parszuto, Marcin Rybacki, Wojciech Wołyniec, Przemysław Rutkowski, Bolesław Rutkowski, Jolanta Walusiak-Skorupa, Alicja Dębska-Ślizień
For a number of years chronic kidney disease (CKD) has been listed in the group of lifestyle diseases, such as obesity, diabetes, cardiovascular disease and hypertension. It is estimated that in Poland more than 4 million people may suffer from various stages of CKD. Chronic kidney disease may also be a consequence of all the other civilization diseases. At the same time it is worth noting that nephrological problems are increasingly being taken into account in modern medical certification. The aim of this work is, among other things, to improve safe access to the labor for patients with kidney diseases...
November 8, 2017: Medycyna Pracy
https://www.readbyqxmd.com/read/29136234/non-apnoea-sleep-disorder-increases-the-risk-of-subsequent-female-infertility-a-nationwide-population-based-cohort-study
#2
I-Duo Wang, Yung-Liang Liu, Chung-Kan Peng, Chi-Hsiang Chung, Shan-Yueh Chang, Chang-Huei Tsao, Wu-Chien Chien
Study Objectives: Non-apnoea sleep disorder (NASD) increases the risk of hypertension, type 2 diabetes mellitus (DM), chronic kidney disease (CKD), cardiovascular disease and stroke. However, the risk and the time interval of NASD to female infertility has not been thoroughly understood. Our study aimed to determine whether NASD increases subsequent risk of female infertility. Methods: This study utilized outpatient and inpatient data from the Longitudinal Health Insurance Database (LHID) between 2000 and 2010 in Taiwan...
November 9, 2017: Sleep
https://www.readbyqxmd.com/read/29127652/dapagliflozin-as-a-cause-of-acute-tubular-necrosis-with-heavy-consequences-a-case-report
#3
Christos Pleros, Elisavet Stamataki, Antonia Papadaki, Nikolaos Damianakis, Rafaela Poulidaki, Charikleia Gakiopoulou, Ioannis Tzanakis
A 50-year-old man with type II diabetes, hypertension and dyslipidemia, presented with non-oliguric acute kidney injury (AKI) and anemia. Renal biopsy showed acute tubular necrosis (ATN) with extensive cytoplasmic vacuolization and areas of tubulitis. These findings were ultimately attributed to dapagliflozin, which he started 3 months earlier due to poor glycemic control. ATN with similar microscopic findings has been described with larger doses of dapagliflozin in non-clinical trials. Our patient was started on dialysis and remained dialysis-dependent for 4 weeks while his renal function improved gradually thereafter...
November 10, 2017: CEN Case Reports
https://www.readbyqxmd.com/read/29127556/nationwide-multicenter-kidney-biopsy-study-of-japanese-patients-with-hypertensive-nephrosclerosis
#4
Kengo Furuichi, Miho Shimizu, Yukio Yuzawa, Akinori Hara, Tadashi Toyama, Hiroshi Kitamura, Yoshiki Suzuki, Hiroshi Sato, Noriko Uesugi, Yoshifumi Ubara, Junichi Hoshino, Satoshi Hisano, Yoshihiko Ueda, Shinichi Nishi, Hitoshi Yokoyama, Tomoya Nishino, Kentaro Kohagura, Daisuke Ogawa, Koki Mise, Yugo Shibagaki, Kenjiro Kimura, Masakazu Haneda, Hirofumi Makino, Seiichi Matsuo, Takashi Wada
BACKGROUND: Nephrosclerosis is an increasingly reason for dialysis in Japan. However, kidney biopsy specimens for hypertensive nephrosclerosis are very limited; thus, the pathologic evaluation of hypertensive nephrosclerosis currently remains unclear. METHODS: Clinical and pathologic data of a total of 184 biopsy-confirmed hypertensive nephrosclerosis patients were collected from 13 centers throughout Japan. Seven pathological findings were assessed in this study...
November 11, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29126987/endothelial-and-kidney-function-in-women-with-a-history-of-preeclampsia-and-healthy-parous-controls-a-case-control-study
#5
Veronica A Lopes van Balen, Julia J Spaan, Tom Cornelis, Wieteke M Heidema, Ralph R Scholten, Marc E A Spaanderman
INTRODUCTION: Preeclampsia (PE) is a pregnancy related endothelial disease characterized by hypertension and albuminuria. Postpartum endothelial dysfunction often persists in these women. We postulate that in women with a history of PE reduced endothelial dependent vasodilation coincides with attenuated kidney function, as both reflect endothelial dysfunction. METHODS: We assessed endothelial and kidney function in women with a history of PE (n=79) and uncomplicated pregnancies (n=49) at least 4years postpartum...
November 8, 2017: Microvascular Research
https://www.readbyqxmd.com/read/29123429/assessment-of-prescribed-medications-and-pattern-of-distribution-for-potential-drug-drug-interactions-among-chronic-kidney-disease-patients-attending-the-nephrology-clinic-of-lagos-university-teaching-hospital-in-sub-saharan-west-africa
#6
Olumuyiwa John Fasipe, Peter Ehizokhale Akhideno, Obiyo Nwaiwu, Alex Adedotun Adelosoye
Introduction: Life expectancy has increased significantly among chronic kidney disease (CKD) patients due to the extensive use of polypharmacy practice for medication prescriptions. This predisposes them to potential drug-drug interactions (DDIs), which can lead to an increase in morbidity, mortality, length of hospital stay, and health care cost. Methods: This was a 30-month retrospective study that reviewed the medical case records of consenting adult CKD patients from January 2014 to June 2016...
2017: Clinical Pharmacology: Advances and Applications
https://www.readbyqxmd.com/read/29121742/retinopathy-and-left-ventricular-hypertrophy-in-patients-with-chronic-kidney-disease-interrelationship-and-impact-on-clinical-outcomes
#7
Yaeni Kim, Jung Sun Cho, Won-Kyung Cho, Hye Eun Yoon, Yu Ah Hong, Yoon Kyung Chang, Chul Woo Yang, Suk Young Kim, Hyeon Seok Hwang
BACKGROUND: Retinopathy and left ventricular hypertrophy (LVH) are representative markers of microvascular and cardiac dysfunction in patients with chronic kidney disease (CKD). However, their relationship and their combined effects on clinical outcomes are unknown. METHODS: We included 401 patients with nondialysis-dependent CKD stage 3-5 who had been examined with fundus photography for diabetic or hypertensive retinopathy. The presence of LVH was identified by echocardiography...
December 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29118884/breast-arterial-calcifications-on-mammography-do-not-predict-myocardial-ischemia-on-myocardial-perfusion-single-photon-emission-computed-tomography
#8
Ahmed Fathala, Salma Salem, Fahad Alanazi, Deema Abunayyan, Abdelmoneim M Eldali, Abdulaziz Alsugair
Background: The aim of this study was to determine if breast arterial calcification (BAC) on mammography predicts myocardial ischemia (MI) on stress myocardial perfusion single-photon emission computed tomography (MPS). BAC is a type of medial artery calcification that can be seen incidentally on mammography, but the relationship between coronary artery calcification and MI on MPS is yet unknown. Methods: A total of 435 consecutive women underwent mammography and stress MPS within 1 year of each other...
October 2017: Cardiology Research
https://www.readbyqxmd.com/read/29109535/prevalence-and-factors-associated-with-chronic-kidney-disease-and-end-stage-renal-disease-in-hiv-1-infected-asian-patients-in-tokyo
#9
Takeshi Nishijima, Yohei Kawasaki, Yoshikazu Mutoh, Kiyomi Tomonari, Kunihisa Tsukada, Yoshimi Kikuchi, Hiroyuki Gatanaga, Shinichi Oka
This single-center cross-sectional study determined the prevalence and factors associated with chronic kidney disease (CKD) and end-stage renal disease (ESRD) in HIV-1-infected Asian patients at the largest HIV clinic in Japan. HIV-1-infected patients who visited the clinic between September and December 2016 were analyzed. CKD was defined as estimated glomerular filtration rate of <60 ml/min/1.73 m(2) or proteinuria ≥1+, observed at least over three months. A logistic regression model was used to estimate the effects of various variables on CKD...
November 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29106632/cost-effectiveness-of-screening-type-2-diabetes-patients-for-chronic-kidney-disease-progression-with-the-ckd273-urinary-peptide-classifier-as-compared-to-urinary-albumin-excretion
#10
Elena Critselis, Antonia Vlahou, Vianda S Stel, Rachael L Morton
Background: In type 2 diabetes mellitus (T2DM) patients, chronic kidney disease (CKD) progression may occur without detectable changes in urinary albumin excretion (UAE) rate. A new urinary peptide classifier (CKD273) has exhibited greater ability to detect CKD progression, however, its cost-effectiveness remains unknown. This study evaluated the cost-effectiveness of screening for CKD progression with the CKD273 classifier, as compared to UAE, in diabetic patients. Methods: A decision-analytic Markov model was developed to estimate costs and health outcomes [including overall survival and quality-adjusted life years (QALYs)] from a health system perspective for adopting a new annual screening strategy based on the CKD273 classifier as compared to annual UAE-based screening in a hypothetical cohort of T2DM patients...
July 3, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29102959/randomized-controlled-trial-of-trc101-to-increase-serum-bicarbonate-in-patients-with-ckd
#11
David A Bushinsky, Thomas Hostetter, Gerrit Klaerner, Yuri Stasiv, Claire Lockey, Sarah McNulty, Angela Lee, Dawn Parsell, Vandana Mathur, Elizabeth Li, Jerry Buysse, Robert Alpern
BACKGROUND AND OBJECTIVES: Metabolic acidosis is common in patients with CKD and has significant adverse effects on kidney, muscle, and bone. We tested the efficacy and safety of TRC101, a novel, sodium-free, nonabsorbed hydrochloric acid binder, to increase serum bicarbonate in patients with CKD and metabolic acidosis. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: One hundred thirty-five patients were enrolled in this randomized, double-blind, placebo-controlled, multicenter, in-unit study (designated the TRCA-101 Study)...
November 4, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29102249/blood-glucose-and-pressure-controls-in-diabetic-kidney-disease-narrative-review-of-adherence-barriers-and-evidence-of-achievement
#12
REVIEW
Fergus William Gardiner, Ezekiel Uba Nwose, Phillip Taderera Bwititi, Judith Crockett, Lexin Wang
AIMS: To review the epidemiology and the clinical evidence regarding achieving blood pressure (BP) and blood glucose control in patients with chronic kidney disease (CKD) and diabetes mellitus (DM), with emphasis on adherence and barriers within the context of Australian clinical guidelines. This article then considers Australian services aimed at BP, DM, and CKD, guideline adherence and control. METHODS: Evidence from PubMed-listed articles published between 1994 and 2016 is considered, including original research, focusing on randomised controlled trials and prospective studies, review articles, meta- analyses, expert and professional bodies' guidelines as well as our experience...
September 15, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29100941/impact-of-clinical-pharmacist-services-delivered-via-telemedicine-in-the-outpatient-or-ambulatory-care-setting-a-systematic-review
#13
REVIEW
Joshua D Niznik, Harvey He, Sandra L Kane-Gill
BACKGROUND: Utilization of telemedicine allows pharmacists to extend the reach of clinical interventions, connecting them with patients and providers, but the overall impact of these services is under-studied. OBJECTIVE: Identify the impact of clinical pharmacist telemedicine interventions on clinical outcomes, subsequently defined as clinical disease management, patient self-management, and adherence, in outpatient or ambulatory settings. METHODS: A literature search was conducted from database inception through May 2016 in Medline, SCOPUS, and EMBASE...
October 28, 2017: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/29096403/impact-of-lean-mass-and-bone-density-on-glomerular-filtration-rate-estimation-in-people-living-with-hiv-aids
#14
Corinne Isnard Bagnis, Laurence Pieroni, Rachida Inaoui, Philippe Maksud, Stéphanie Lallauret, Marc-Antoine Valantin, Roland Tubiana, Christine Katlama, Gilbert Deray, Marie Courbebaisse, Jérôme Tourret, Sophie Tezenas du Montcel
CONTEXT: Chronic kidney disease is a frequent complication in persons living with HIV/AIDS. Although previous studies have suggested that the CKD-EPI formula is appropriate to estimate glomerular filtration rate (GFR) in HIV-positive adults with normal kidney function, the optimal way to estimate GFR in those with Stage 3 chronic kidney disease is not known. Moreover, the impact of muscle mass on creatinine level and GFR estimation is unknown. AIM AND METHODS: Our study aimed to evaluate the accuracy of different diagnostic tests available compared to the gold standard measurement of GFR...
2017: PloS One
https://www.readbyqxmd.com/read/29095051/body-fat-indicators-and-kidney-function-decline-in-older-post-myocardial-infarction-patients-the-alpha-omega-cohort-study
#15
Kevin Esmeijer, Johanna M Geleijnse, Erik J Giltay, Theo Stijnen, Friedo W Dekker, Johan W de Fijter, Daan Kromhout, Ellen K Hoogeveen
Background Obesity increases risk of hypertension and diabetes, the leading causes of end-stage renal disease. The effect of obesity on kidney function decline in stable post-myocardial infarction patients is poorly documented. This relation was investigated in a large cohort of older post-myocardial infarction patients. Design Data were analysed from 2410 post-myocardial infarction patients in the Alpha Omega Trial, aged 60-80 years receiving optimal pharmacotherapy treatment (79% men, 18% diabetes). Methods Cystatin C based estimated glomerular filtration rate (eGFRcysC) was calculated at baseline and after 41 months, using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29094330/the-association-between-elevated-serum-uric-acid-level-and-an-increased-risk-of-renal-function-decline-in-a-health-checkup-cohort-in-china
#16
Xia Cao, Liuxin Wu, Zhiheng Chen
PURPOSE: To investigate whether an elevated serum uric acid (SUA) level is an independent risk factor for rapid decline in renal function or new-onset chronic kidney disease (CKD) in a Chinese health checkup population. METHODS: A cohort study of 6495 Chinese individuals who underwent health checkups with normal estimated glomerular filtration rate (eGFR) at baseline was carried out from May 2011 to April 2016. Examinations included a questionnaire, physical measurements, and blood sampling...
November 1, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/29081996/chronic-kidney-disease-in-low-income-to-middle-income-countries-the-case-for-increased-screening
#17
REVIEW
Cindy George, Amelie Mogueo, Ikechi Okpechi, Justin B Echouffo-Tcheugui, Andre Pascal Kengne
Chronic kidney disease (CKD) is fast becoming a major public health issue, disproportionately burdening low-income to middle-income countries, where detection rates remain low. We critically assessed the extant literature on CKD screening in low-income to middle-income countries. We performed a PubMed search, up to September 2016, for studies on CKD screening in low-income to middle-income countries. Relevant studies were summarised through key questions derived from the Wilson and Jungner criteria. We found that low-income to middle-income countries are ill-equipped to deal with the devastating consequences of CKD, particularly the late stages of the disease...
2017: BMJ Global Health
https://www.readbyqxmd.com/read/29077007/altered-metabolism-of-blood-manganese-is-associated-with-low-levels-of-hemoglobin-in-patients-with-chronic-kidney-disease
#18
Minyoung Kim, Eun Sil Koh, Sungjin Chung, Yoon Sik Chang, Seok Joon Shin
Blood manganese (Mn) level has been reported to be higher in patients with anemia or iron deficiency. The purpose of this study was to analyze the relationship between blood Mn level and anemia in patients with chronic kidney disease (CKD). A total of 334 patients with CKD who were not treated with dialysis were included in this study. Blood Mn level and serum markers regarding anemia, renal function, and nutrition were measured and analyzed. Median blood Mn level was 8.30 (interquartile range(IQR): 5.27-11...
October 27, 2017: Nutrients
https://www.readbyqxmd.com/read/29071505/an-equation-to-estimate-the-renal-cortex-volume-in-chronic-kidney-disease-patients
#19
Takashi Nakazato, Hiroo Ikehira, Toshiyuki Imasawa
BACKGROUND: The renal cortex volume is associated with the kidney function and chronic kidney disease (CKD) risk factors, and it may also be a prognostic factor. We aimed to create an equation to estimate the renal cortex volume of CKD patients in day-to-day clinical practice. METHODS: The subjects included 116 ethnic Japanese CKD patients who were ≥ 18 years of age. The renal size (length, width and thickness) was measured by ultrasound. The body height, weight, year of age, sex, birth weight, gestational age, diabetes status, hypertension status, family history of CKD and dialysis and estimated glomerular filtration rate (eGFR) were collected as expected dependent variables...
October 25, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29070470/-association-between-hypertriglyceridemic-waist-to-height-ratio-phenotype-and-chronic-kidney-disease-in-a-community-population-in-south-china-a-cross-sectional-study
#20
Xiao-Fei Shao, Bi-Fang Wu, Ai-Qun Liu, Bin Li, Yong-Qiang Li, Qin Zhou, He-Qun Zou
OBJECTIVE: To investigate the relationship between hypertriglyceridemic waist to height ratio phenotype (HWHtR) and chronic kidney disease (CKD) in a community population in South China. METHODS: A cross sectional study was conducted among 2142 residents in Zhuhai (Guangdong Province, China) from June to October of 2012. The HWHtR phenotype was defined as a waist to height ratio(WHtR) ≥0.55 and triglyceride level ≥2.0 mmol/L, based on which the participants were divided into HWHtR group and nonHWHtR group...
October 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
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