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https://www.readbyqxmd.com/read/29342308/chronic-kidney-disease-burden-among-african-migrants-in-three-european-countries-and-in-urban-and-rural-ghana-the-rodam-cross-sectional-study
#1
David N Adjei, Karien Stronks, Dwomoa Adu, Erik Beune, Karlijn Meeks, Liam Smeeth, Juliet Addo, Ellis Owuso-Dabo, Kerstin Klipstein-Grobusch, Frank P Mockenhaupt, Matthias B Schulze, Ina Danquah, Joachim Spranger, Silver Bahendeka, Ama de-Graft Aikins, Charles Agyemang
Background: Chronic kidney disease (CKD) is a major burden among sub-Saharan African (SSA) populations. However, differences in CKD prevalence between rural and urban settings in Africa, and upon migration to Europe are unknown. We therefore assessed the differences in CKD prevalence among homogenous SSA population (Ghanaians) residing in rural and urban Ghana and in three European cities, and whether conventional risk factors of CKD explained the observed differences. Furthermore, we assessed whether the prevalence of CKD varied among individuals with hypertension and diabetes compared with individuals without these conditions...
January 12, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29331037/pharmacist-intervention-for-blood-pressure-control-in-patients-with-diabetes-and-or-chronic-kidney-disease
#2
Maxwell D Anderegg, Tyler H Gums, Liz Uribe, Eric J MacLaughlin, James Hoehns, Oralia V Bazaldua, Timothy J Ives, David L Hahn, Christopher S Coffey, Barry L Carter
OBJECTIVES: The objectives of this study were to 1) determine if hypertensive patients with comorbid diabetes mellitus (DM) and/or chronic kidney disease (CKD) receiving a pharmacist intervention had a greater reduction in mean blood pressure (BP) and improved BP control at 9 months compared to those receiving usual care and 2) compare Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC-7) guideline and 2014 guideline (JNC-8) BP control rates in patients with DM and/or CKD...
January 13, 2018: Pharmacotherapy
https://www.readbyqxmd.com/read/29330695/glucosuria-and-all-cause-mortality-among-general-screening-participants
#3
Kunitoshi Iseki, Tsuneo Konta, Koichi Asahi, Kunihiro Yamagata, Shouichi Fujimoto, Kazuhiko Tsuruya, Ichiei Narita, Masato Kasahara, Yugo Shibagaki, Toshiki Moriyama, Masahide Kondo, Chiho Iseki, Tsuyoshi Watanabe
BACKGROUND: Dipstick urine tests are used for general health screening in Japan, but how the test results (e.g., glucosuria) relate to mortality is unknown. METHODS: Subjects participated in a nationwide screening in 2008 in six districts in Japan. We identified those who might have died using the national database of death certificates from 2008 to 2012 (total registered ~ 6 million) and verified candidates with the regional National Health Insurance Agency and public health nurses...
January 12, 2018: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29326180/prevalence-and-burden-of-chronic-kidney-disease-among-the-general-population-and-high-risk-groups-in-africa-a-systematic-review
#4
Samar Abd ElHafeez, Davide Bolignano, Graziella D'Arrigo, Evangelia Dounousi, Giovanni Tripepi, Carmine Zoccali
OBJECTIVES: While increasing attention is paid to the rising prevalence of chronic diseases in Africa, there is little focus on chronic kidney disease (CKD). This systematic review assesses CKD burden among the general population and high-risk groups on the entire African continent. DESIGN, SETTING AND PARTICIPANTS: We searched Medline and PubMed databases for articles published between 1 January 1995 and 7 April 2017 by sensitive search strategies focusing on CKD surveys at the community level and high-risk groups...
January 10, 2018: BMJ Open
https://www.readbyqxmd.com/read/29325997/reduced-cortical-oxygenation-predicts-a-progressive-decline-of-renal-function-in-patients-with-chronic-kidney-disease
#5
Menno Pruijm, Bastien Milani, Edward Pivin, Agata Podhajska, Bruno Vogt, Matthias Stuber, Michel Burnier
Renal tissue hypoxia is a final pathway in the development and progression of chronic kidney disease (CKD), but whether renal oxygenation predicts renal function decline in humans has not been proven. Therefore, we performed a prospective study and measured renal tissue oxygenation by blood oxygenation level-dependent magnetic resonance imaging (BOLD-MRI) in 112 patients with CKD, 47 with hypertension without CKD, and 24 healthy control individuals. Images were analyzed with the twelve-layer concentric objects method that divided the renal parenchyma in 12 layers of equal thickness and reports the mean R2* value of each layer (a high R2* corresponds to low oxygenation), along with the change in R2* between layers called the R2* slope...
January 9, 2018: Kidney International
https://www.readbyqxmd.com/read/29322980/neurology-of-renal-disorders
#6
Pushpendra N Renjen, Dinesh Chaudhari, Gaurav Sagar, Sanjiv Jasuja
Chronic kidney disease (CKD) is a critical and rapidly growing global health problem. Neurological complications occur in almost all patients with severe CKD, potentially affecting all levels of the nervous system, from the central nervous system (CNS) through to the peripheral nervous system (PNS). Patients with CKD exhibit a high incidence of symptomatic and occult cerebrovascular diseases, associated tremendously high levels of inflammatory factors and homocysteine, as well as anemia, hypertension, and diabetes...
January 2018: Neurology India
https://www.readbyqxmd.com/read/29319764/prevalence-of-chronic-kidney-disease-in-a-population-in-southern-brazil-pro-renal-study
#7
Ana Paula Piccolli, Marcelo Mazza do Nascimento, Miguel Carlos Riella
INTRODUCTION: Chronic kidney disease (CKD) affects 10-12% of the adult population in many countries. In Brazil, there is no reliable information about the actual prevalence of CKD. OBJECTIVE: To determine the prevalence of CKD by estimated glomerular filtration rate (eGFR) and proteinuria/albuminuria in an urban population randomly selected in Southern Brazil. Patients and. METHODS: 5,216 individuals were randomly selected out of a pool of 10,000 individuals identified from the database of a local energy company...
October 2017: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/29317956/effect-of-angiotensin-converting-enzyme-inhibitor-calcium-antagonist-combination-therapy-on-renal-function-in-hypertensive-patients-with-chronic-kidney-disease-chikushi-anti-hypertension-trial-benidipine-and-perindopril
#8
Tetsu Okuda, Keisuke Okamura, Kazuyuki Shirai, Hidenori Urata
Background: Appropriate blood pressure control suppresses progression of chronic kidney disease (CKD). If an angiotensin-converting enzyme (ACE) inhibitor is ineffective, adding a calcium antagonist is recommended. We compared the long-term effect of two ACE inhibitor/calcium antagonist combinations on renal function in hypertensive patients with CKD. Methods: Patients who failed to achieve the target blood pressure (systolic/diastolic: < 130/80 mm Hg) with perindopril monotherapy were randomized to either combined therapy with perindopril and the L-type calcium antagonist amlodipine (group A) or perindopril and the T/L type calcium antagonist benidipine (group B)...
February 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29304216/hypertension-control-in-adults-with-ckd-in-china-baseline-results-from-the-chinese-cohort-study-of-chronic-kidney-disease-c-stride
#9
Zhe Yan, Yu Wang, Shaomei Li, Jinwei Wang, Luxia Zhang, Huibin Tan, Sumin Li, Lin Yang, Huaying Pei, Liping Zhang, Yan Wang, Jianzhao Duan, Sumin Jiao, Minghui Zhao, Shuxia Fu
Background: Hypertension contributes to increased morbidity and mortality in the chronic kidney disease (CKD) population. Studies on blood pressure control in CKD patients in China are limited. In this study, we aimed to describe the status of blood pressure control in Chinese CKD patients based on the first national prospective CKD cohort data. Methods: A subgroup of Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE) participants with hypertension at baseline was included in the present study...
January 3, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29302463/prevalence-and-correlates-of-chronic-kidney-disease-in-a-group-of-patients-with-hypertension-in-the-savanah-zone-of-cameroon-a-cross-sectional-study-in-sub-saharan-africa
#10
Ba Hamadou, Jérôme Boombhi, Félicité Kamdem, Adeline Fitame, Sylvie Ndongo Amougou, Liliane Kuate Mfeukeu, Chris Nadège Nganou, Alain Menanga, Gloria Ashuntantang
Background: The prevalence of chronic kidney disease (CKD) is increasing worldwide due to an increase in the risk factors such as hypertension. The greatest burden is in low-income settings, coupled with late diagnosis and limited management resources. This work aimed at studying the prevalence and risk factors of CKD in a group of patients with hypertension in the Savanah zone in Sub-Saharan Africa (SSA). Methods: We carried out a cross-sectional study between January and May 2016 in the regional Hospital of Garoua-Cameroon...
December 2017: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/29301002/should-we-eat-more-potassium-to-better-control-blood-pressure-in-hypertension
#11
Michel Burnier
Changes in lifestyle and nutrition are recommended as the first-step approach to the management of hypertension by all national and international guidelines. Today, when considering nutritional factors in hypertension, almost all the attention is focused on the reduction of salt intake to improve blood pressure (BP) control. Changes in potassium intake are only briefly evoked in guidelines. Few physicians actually think about proposing to eat more foods that are high in potassium (fruits, vegetables, nuts) to better control BP...
January 2, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29295829/medication-therapy-management-after-hospitalization-in-ckd-a-randomized-clinical-trial
#12
Katherine R Tuttle, Radica Z Alicic, Robert A Short, Joshua J Neumiller, Brian J Gates, Kenn B Daratha, Celestina Barbosa-Leiker, Sterling M McPherson, Naomi S Chaytor, Brad P Dieter, Stephen M Setter, Cynthia F Corbett
BACKGROUND AND OBJECTIVES: CKD is characterized by remarkably high hospitalization and readmission rates. Our study aim was to test a medication therapy management intervention to reduce subsequent acute care utilization. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: The CKD Medication Intervention Trial was a single-blind (investigators), randomized clinical trial conducted at Providence Health Care in Spokane, Washington. Patients with CKD stages 3-5 not treated by dialysis who were hospitalized for acute illness were recruited...
January 2, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29285723/the-divalent-elements-changes-in-early-stages-of-chronic-kidney-disease
#13
Wan-Ju Kung, Ching-Tang Shih, Chien-Hung Lee, Ching-Chiang Lin
As the glomerular filtration rate (GFR) decreases, it can cause imbalance in some divalent elements. These imbalances can cause increased oxidative stress in patients with renal impairment. The aim of present study was to investigate the changes of these divalent elements with CKD progression. One hundred and ninety-four patients with chronic kidney diseases (CKD) were divided into five stages, stage 1, 2, 3a, 3b, 4, and were recruited into this study. The divalent elements, calcium, magnesium, phosphorus, as well as iron, zinc, and copper were determined in clinical chemistry analyzer...
December 28, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/29284530/fimasartan-proteinuria-sustained-reduction-in-comparison-with-losartan-in-diabetic-chronic-kidney-disease-fantastic-study-protocol-for-randomized-controlled-trial
#14
Jang-Young Kim, Jung-Woo Son, Sungha Park, Tea-Hyun Yoo, Yong-Jin Kim, Dong-Ryeol Ryu, Ho Jun Chin
BACKGROUND: Fimasartan is the ninth angiotensin receptor blocker to be developed. However, it has not yet been evaluated for reno-protective effects in hypertensive diabetic chronic kidney disease (CKD). The target blood pressure (BP) for hypertensive diabetic CKD is also a controversial topic. This trial was designed to assess the reno-protective effects of fimasartan compared to those of losartan as a primary outcome. This study also compares the two drugs with regard to cardiovascular and renal outcomes in accordance with target systolic BP (SBP) (as secondary outcomes)...
December 29, 2017: Trials
https://www.readbyqxmd.com/read/29282014/spectrum-characteristics-of-patients-with-chronic-kidney-disease-ckd-with-increasing-age-in-a-major-metropolitan-renal-service
#15
Usman Mahmood, Helen G Healy, Adrian Kark, Anne Cameron, Zaimin Wang, Rajitha Abeysekera, Wendy E Hoy
BACKGROUND: Aim of our study is to describe, in people with CKD, the demographic and clinical characteristics and outcomes with increasing age. The prevalence of CKD in Western populations, where longevity is the norm, is about 10-15%, but how age influence different characteristics of patients with CKD is largely not known. METHODS: One thousand two hundred sixty-five patients enrolled in the CKD.QLD registry at the Royal Brisbane and Women's Hospital were grouped according to age at consent i...
December 28, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/29276928/-prevalence-of-markers-of-chronic-kidney-disease-in-patients-with-arterial-hypertension-results-of-epidemiological-study-chronograf
#16
A M SHutov, Z D Kobalava, S V Villevalde, N Y Borovkova, T E Nichik, G S Safuanova
In an noninterventional observational open multicenter program CHRONOGRAF the prevalence of markers of chronic kidney disease (CKD) was studied in 1600 patients with arterial hypertension with and without type 2 diabetes mellitus. Glomerular filtration rate (GFR) was calculated (CKD‑EPI formula) and albuminuria (AU) was determined as albumin/creatinine (A/Cr) ratio in the morning portion of urine. In 49.4% of patients decreased GFR 30 mg/g was detected. Decrease of GFR 30 mg/g - in 32.6%, combination of reduced GFR and high/very high AU - in 18%...
October 2017: Kardiologiia
https://www.readbyqxmd.com/read/29245978/chronic-kidney-disease-is-associated-with-a-risk-of-higher-mortality-following-total-knee-arthroplasty-in-diabetic-patients-a-nationwide-population-based-study
#17
Liang-Tseng Kuo, Su-Ju Lin, Chi-Lung Chen, Pei-An Yu, Wei-Hsiu Hsu, Tien-Hsing Chen
Diabetes and chronic kidney disease (CKD) are associated with a higher rate of complications in patients undergoing total knee arthroplasty (TKA). The purpose of this study was to determine the effects of CKD and diabetes in patients after TKA. Diabetic patients who received unilateral primary TKA between January 2008 and December 2011 were enrolled. The follow-up period was more than 6 months. The primary outcome was a TKA-related infection and the secondary outcome was all-cause mortality. The study cohort included 13844 patients who were followed for a mean period of 2 years, of whom 1459 (10...
November 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/29243213/accuracy-of-co-morbidity-data-in-patients-undergoing-abdominal-wall-hernia-repair-a-retrospective-study
#18
S Hajibandeh, S Hajibandeh, R Deering, D McEleney, J Guirguis, S Dix, A Sreh, E Toner, A El Muntasar, A Kausar, G Sheikh, D OShea, A Shafiq, A Kelly, A Khan, D Arumugam, A Evans
OBJECTIVES: To determine the baseline accuracy, sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of routinely collected co-morbidity data in patients undergoing abdominal wall hernia repair. METHODS: All patients aged > 18 who underwent umbilical, para-umbilical, inguinal or incisional hernia repair between 1 January 2015 and 1 November 2016 were identified. All parts of the clinical notes were searched for co-morbidities by two authors independently...
December 14, 2017: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/29242368/lessons-from-ckd-related-genetic-association-studies-moving-forward
#19
Sophie Limou, Nicolas Vince, Afshin Parsa
Over the past decade, genetic association studies have uncovered numerous determinants of kidney function in the general, diabetic, hypertensive, CKD, ESRD, and GN-based study populations (e.g., IgA nephropathy, membranous nephropathy, FSGS). These studies have led to numerous novel and unanticipated findings, which are helping improve our understanding of factors and pathways affecting both normal and pathologic kidney function. In this review, we report on major discoveries and advances resulting from this rapidly progressing research domain...
December 14, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29226654/evaluation-of-hepcidin-and-atherosclerosis-in-dialysis-patients
#20
Victor Manolov, Julia Petrova, Boris Bogov, Savina Hadjidekova, Vasil Vasilev, Dyana Yonova, Maria Petrova, Todor Kunchev, Yavor Jelev, Petar Jeliazkov, Borislav Marinov, Ivo Bogov, Zlatina Gramatikova, Silviya Voleva, Kamen Tzatchev, Latchezar Traykov
BACKGROUND: Chronic kidney disease (CKD) is a condition that involves 10% - 15% of population worldwide, which increases the risk of cardio-vascular diseases (CVD). Chronic kidney disease is one of the main reasons for illness and mortality in the world. Chronic kidney disease is a serious health problem caused by involvement of a large number of patients with kidney injury, especially in industrial countries. Among the main reasons for this are population living longer and the number of diseases in elderly persons, such as diabetes mellitus type 2, hypertension, and cardio-vascular diseases...
November 1, 2017: Clinical Laboratory
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