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Tiffany L Grisbrook, Pippa Kenworthy, Michael Phillips, Fiona M Wood, Dale W Edgar
Bioimpedance spectroscopy (BIS) is a tool utilized in health care to investigate body composition and fluid distribution. Limited research has addressed the clinical use of BIS in burns. This study aimed to examine the effects of silver dressings on BIS measurements in burns patients. BIS measurements were collected during two dressing conditions: no dressing (ND), and; Acticoat™ dressing (AD). Wilcoxon sign-ranks tests determined if there were any significant differences in BIS measures between the dressing conditions...
April 30, 2016: Burns: Journal of the International Society for Burn Injuries
Joshua Ravensdale, Fiona Wood, Francis O'Brien, Keith Gregg
Multiple studies have shown that the antibacterial dressing Acticoat can inhibit growth of bacteria but is unable to completely clear a wound of infection, which could leave patients vulnerable to sepsis. Agar inoculated with four different Staphylococcus aureus strains and overlain with Acticoat showed growth inhibition beneath and within a 1 mm perimeter of the dressing after 24 h. When lifted from inoculated agar and briefly blotted onto fresh agar plates, Acticoat transferred viable bacteria. Scanning electron microscopy of the surface of Acticoat that overlaid meticillin-resistant S...
May 2016: Journal of Medical Microbiology
Carol A Hartmann, Heinz Rode, Beverley Kramer
Acticoat(TM) has antimicrobial and anti-inflammatory effects which aid wound healing. However, in vitro studies indicate that Acticoat™ is cytotoxic and clinical and in vivo studies suggest that it may delay healing in acute wounds. Therefore, this study investigated the effects of Acticoat™ on healing in acute full-thickness excisional wounds. Using a porcine model, healing was assessed on days 3, 6, 9 and 15 post-wounding. Five wounds dressed with Acticoat™ and five wounds dressed with polyurethane film (control) were assessed per day (n = 40 wounds)...
November 11, 2015: International Wound Journal
D Zweiker, S Horn, A Hoell, S Seitz, D Walter, M Trop
A 17-year-old male with burns to 8% of his total body surface area was treated for 10 days with Acticoat(®), a nanocrystalline silver dressing. The burns, which were on his back and shoulder, healed without infection. However, a skin discoloration in the wound area and the adjacent uninjured skin appeared in the first days of treatment. The staining remained visible even after the treatment had ended and disappeared approximately three years later. Despite the outstanding antimicrobial properties, possible side effects of silver nanocrystalline dressings should be kept in mind...
December 31, 2014: Annals of Burns and Fire Disasters
Neil H Riordan, Ben A George, Troy B Chandler, Randall W McKenna
INTRODUCTION: Non-healing wounds can pose a medical challenge as in the case of vasculopathic venostasis resulting in a surgical ulcer. When traditional approaches to wound care fail, an amniotic patch (a dehydrated tissue allograft derived from human amnion) can function as a biologic scaffold to facilitate and enhance tissue regeneration and rehabilitation. BACKGROUND: Amniotic AlphaPatches contain concentrated molecules of PGE2, WNT4, and GDF-11 which have angiogenic, trophic, and anti-inflammatory effects on tissues that may be useful in enhancing wound healing...
2015: Journal of Translational Medicine
Fenella D Halstead, Maryam Rauf, Amy Bamford, Christopher M Wearn, Jonathan R B Bishop, Rebecca Burt, Adam P Fraise, Naiem S Moiemen, Beryl A Oppenheim, Mark A Webber
UNLABELLED: Antimicrobial medicated dressings (AMD) are often used to reduce bacterial infection of burns and other wounds. However, there is limited literature regarding comparative efficacies to inform effective clinical decision making. OBJECTIVES: Following on from a previous study where we demonstrated good antibiofilm properties of acetic acid (AA), we assessed and compared the in vitro anti-biofilm activity of a range of AMDs and non-AMDs to AA. METHODS: Laboratory experiments determined the ability of a range of eleven commercial AMD, two nAMD, and AA, to prevent the formation of biofilms of a panel of four isolates of Pseudomonas aeruginosa and Acinetobacter baumannii...
December 2015: Burns: Journal of the International Society for Burn Injuries
Matthew Brown, Stuart R Dalziel, Eleanor Herd, Kathryn Johnson, Richard Wong She, Michael Shepherd
Silver-impregnated dressings are increasingly preferred over silver sulfadiazine cream in the management of pediatric burns. An ideal burns dressing would provide a moist, sterile environment, discourage infection, and not require painful dressing changes. This study sought to determine whether silver sodium carboxymethyl cellulose (Aquacel Ag, ConvaTec, Greensboro, NC) dressing is a superior treatment to nanocrystalline silver-coated polyethylene (Acticoat, Smith & Nephew, London, United Kingdom) dressing in pediatric patients with partial thickness burns...
July 2016: Journal of Burn Care & Research: Official Publication of the American Burn Association
Yu-Hsin Lin, Wei-Shan Hsu, Wan-Yu Chung, Tse-Hao Ko, Jui-Hsiang Lin
Various types of wound dressings have been designed for different purposes and functions. Controlling bacterial burden in a wound during the early phase is important for successful wound repair. Once bacterial burden is under control, the active promotion of wound healing is another important factor for efficient wound healing. This study investigated the potential of three silver-containing dressings, namely KoCarbonAg(®) , Aquacel(®) Ag and Acticoat 7, in reducing bacterial survival and promoting wound healing...
August 2016: International Wound Journal
Eui Dong Yeo, Su Ah Yoon, Seong Rok Oh, Young Suk Choi, Young Koo Lee
UNLABELLED: Silver-containing dressings are commonly used on healing wounds, including diabetic ulcers. Some studies have shown that dressing materials with silver have negative effects on wound healing, specifically, that the wound healing process is inhibited by deposited silver. Therefore, the authors treated wounds infected with methicillin-resistant Staphylococcus aureus (MRSA) in Sprague-Dawley (SD) rats and streptozotocin (STZ)-induced diabetic rats with silver dressings to evaluate the risks of silver...
April 2015: Wounds: a Compendium of Clinical Research and Practice
Nathan Hamnett, Amrita Chandra, Eleni Chamaidi, Azzam Farroha
No abstract text is available yet for this article.
July 2016: Journal of Burn Care & Research: Official Publication of the American Burn Association
E L Gee Kee, R M Kimble, L Cuttle, A Khan, K A Stockton
BACKGROUND: This study compared the effects of three silver dressing combinations on small to medium size acute partial thickness burns in children, focusing on re-epithelialization time, pain and distress during dressing changes. METHOD: Children (0-15 years) with clean, ≤ 10% total body surface area (TBSA) partial thickness burns who met the inclusion criteria were included in the study. Children received either (1) Acticoat™; (2) Acticoat™ with Mepitel™; or (3) Mepilex Ag™ dressings...
August 2015: Burns: Journal of the International Society for Burn Injuries
Lim Jeong, Min Hee Kim, Ju-Young Jung, Byung Moo Min, Won Ho Park
BACKGROUND: One of the promising applications of silk fibroin (SF) in biomedical engineering is its use as a scaffolding material for skin regeneration. The purpose of this study was to determine the wound healing effect of SF nanofibrous matrices containing silver sulfadiazine (SSD) wound dressings. METHODS: An SF nanofibrous matrix containing SSD was prepared by electrospinning. The cell attachment and spreading of normal human epidermal keratinocytes (NHEK) and normal human epidermal fibroblasts (NHEF) to SF nanofibers containing three different concentrations of SSD contents (0...
2014: International Journal of Nanomedicine
Benjawan Boonkaew, Philip M Barber, Sirirat Rengpipat, Pitt Supaphol, Margit Kempf, Jibao He, Vijay T John, Leila Cuttle
Patients with burn wounds are susceptible to wound infection and sepsis. This research introduces a novel burn wound dressing that contains silver nanoparticles (SNPs) to treat infection in a 2-acrylamido-2-methylpropane sulfonic acid sodium salt (AMPS-Na(+) ) hydrogel. Silver nitrate was dissolved in AMPS-Na(+) solution and then exposed to gamma irradiation to form SNP-infused hydrogels. The gamma irradiation results in a cross-linked polymeric network of sterile hydrogel dressing and a reduction of silver ions to form SNPs infused in the hydrogel in a one-step process...
October 2014: Journal of Pharmaceutical Sciences
Hugo C Guthrie, Kevin R Martin, Christopher Taylor, Abigail M Spear, Rachel Whiting, Sara Macildowie, Jonathan C Clasper, Sarah A Watts
Prevention of extremity war wound infection remains a clinical challenge. Staphylococcus aureus is the most common pathogen in delayed infection. We hypothesised that choice of wound dressings may affect bacterial burden over 7 days reflecting the current practice of delayed primary closure of wounds within this timeframe. A randomised controlled trial of 3 commercially available dressings (Inadine(®) (Johnson & Johnson, NJ, USA), Acticoat(®) (Smith & Nephew, Hull, UK), Activon Tulle (Advancis Medical, Nottingham, UK)) was conducted in a rabbit model of contaminated forelimb muscle injury...
August 2014: Injury
Purushottam V Gawande, Allie P Clinton, Karen LoVetri, Nandadeva Yakandawala, Kendra P Rumbaugh, Srinivasa Madhyastha
Chronic wounds including diabetic foot ulcers, pressure ulcers, and venous leg ulcers are a worldwide health problem. As the traditional methods of treatment have proven ineffective against chronic wounds involving biofilms, there is an unmet clinical need for developing products with an antibiofilm component that inhibits and/or disrupts biofilms and thus make the biofilm-embedded bacteria more susceptible to antimicrobial therapy. We developed a DispersinB® antibiofilm enzyme-based wound spray for treating chronic wounds in conjunction with an antimicrobial...
2014: Microbiology Insights
Benjawan Boonkaew, Margit Kempf, Roy Kimble, Leila Cuttle
A novel burn wound hydrogel dressing has been previously developed which is composed of 2-acrylamido-2-methylpropane sulfonic acid sodium salt with silver nanoparticles (silver AMPS). This study compared the cytotoxicity of this dressing to the commercially available silver products; Acticoat™, PolyMem Silver(®) and Flamazine™ cream. Human keratinocytes (HaCaT and primary HEK) and normal human fibroblasts (NHF) were exposed to dressings incubated on Nunc™ polycarbonate inserts for 24, 48 and 72h. Four different cytotoxicity assays were performed including; Trypan Blue cell count, MTT, Celltiter-Blue™ and Toluidine Blue surface area assays...
December 2014: Burns: Journal of the International Society for Burn Injuries
Geraldine Mulley, A Tobias A Jenkins, Nicholas R Waterfield
There has been a recent surge in the use of silver as an antimicrobial agent in a wide range of domestic and clinical products, intended to prevent or treat bacterial infections and reduce bacterial colonization of surfaces. It has been reported that the antibacterial and cytotoxic properties of silver are affected by the assay conditions, particularly the type of growth media used in vitro. The toxicity of Ag+ to bacterial cells is comparable to that of human cells. We demonstrate that biologically relevant compounds such as glutathione, cysteine and human blood components significantly reduce the toxicity of silver ions to clinically relevant pathogenic bacteria and primary human dermal fibroblasts (skin cells)...
2014: PloS One
C A Fries, Y Ayalew, J G Penn-Barwell, K Porter, S L A Jeffery, M J Midwinter
INTRODUCTION: Recent conflicts have been characterised by the use of improvised explosive devices causing devastating injuries, including heavily contaminated wounds requiring meticulous surgical debridement. After being rendered surgical clean, these wounds are dressed and the patient transferred back to the UK for on-going treatment. A dressing that would prevent wounds from becoming colonised during transit would be desirable. The aim of this study was to establish whether using nanocrystalline silver dressings, as an adjunct to the initial debridement, would positively affect wound microbiology and wound healing compared to standard plain gauze dressings...
July 2014: Injury
M Miraftab, R Masood, V Edward-Jones
Heavily exudating wounds can lead to infection and unnecessary trauma if they are not adequately managed. Manufacturers involved in production and marketing of high absorption silver dressings, besides emphasising high absorptions of their dressings are keen to highlight potent antimicrobial abilities of their products against all kinds of pathogens including MRSA. However, there are little or no credible reports on minimal but potent quantities of silver needed in a dressing to eliminate bacteria spread and growth or how effectively the silver within a dressing is released over time...
January 30, 2014: Carbohydrate Polymers
Emma Gee Kee, Roy M Kimble, Leila Cuttle, Kellie Stockton
BACKGROUND: In the paediatric population, pain and distress associated with burn injuries during wound care procedures remain a constant challenge. Although silver dressings are the gold standard for burn care in Australasia, very few high-level trials have been conducted that compare silver dressings to determine which will provide the best level of care clinically. Therefore, for paediatric patients in particular, identifying silver dressings that are associated with lower levels of pain and rapid wound re-epithelialisation is imperative...
2013: Trials
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