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https://www.readbyqxmd.com/read/27893080/travel-associated-zika-virus-disease-acquired-in-the-americas-through-february-2016-a-geosentinel-analysis
#1
Davidson H Hamer, Kira A Barbre, Lin H Chen, Martin P Grobusch, Patricia Schlagenhauf, Abraham Goorhuis, Perry J J van Genderen, Israel Molina, Hilmir Asgeirsson, Phyllis E Kozarsky, Eric Caumes, Stefan H Hagmann, Frank P Mockenhaupt, Gilles Eperon, Elizabeth D Barnett, Emmanuel Bottieau, Andrea K Boggild, Philippe Gautret, Noreen A Hynes, Susan Kuhn, R Ryan Lash, Karin Leder, Michael Libman, Denis J M Malvy, Cecilia Perret, Camilla Rothe, Eli Schwartz, Annelies Wilder-Smith, Martin S Cetron, Douglas H Esposito
Background: Zika virus has spread rapidly in the Americas and has been imported into many nonendemic countries by travelers. Objective: To describe clinical manifestations and epidemiology of Zika virus disease in travelers exposed in the Americas. Design: Descriptive, using GeoSentinel records. Setting: 63 travel and tropical medicine clinics in 30 countries. Patients: Ill returned travelers with a confirmed, probable, or clinically suspected diagnosis of Zika virus disease seen between January 2013 and 29 February 2016...
November 22, 2016: Annals of Internal Medicine
https://www.readbyqxmd.com/read/27863251/genetic-drivers-of-epigenetic-and-transcriptional-variation-in-human-immune-cells
#2
Lu Chen, Bing Ge, Francesco Paolo Casale, Louella Vasquez, Tony Kwan, Diego Garrido-Martín, Stephen Watt, Ying Yan, Kousik Kundu, Simone Ecker, Avik Datta, David Richardson, Frances Burden, Daniel Mead, Alice L Mann, Jose Maria Fernandez, Sophia Rowlston, Steven P Wilder, Samantha Farrow, Xiaojian Shao, John J Lambourne, Adriana Redensek, Cornelis A Albers, Vyacheslav Amstislavskiy, Sofie Ashford, Kim Berentsen, Lorenzo Bomba, Guillaume Bourque, David Bujold, Stephan Busche, Maxime Caron, Shu-Huang Chen, Warren Cheung, Oliver Delaneau, Emmanouil T Dermitzakis, Heather Elding, Irina Colgiu, Frederik O Bagger, Paul Flicek, Ehsan Habibi, Valentina Iotchkova, Eva Janssen-Megens, Bowon Kim, Hans Lehrach, Ernesto Lowy, Amit Mandoli, Filomena Matarese, Matthew T Maurano, John A Morris, Vera Pancaldi, Farzin Pourfarzad, Karola Rehnstrom, Augusto Rendon, Thomas Risch, Nilofar Sharifi, Marie-Michelle Simon, Marc Sultan, Alfonso Valencia, Klaudia Walter, Shuang-Yin Wang, Mattia Frontini, Stylianos E Antonarakis, Laura Clarke, Marie-Laure Yaspo, Stephan Beck, Roderic Guigo, Daniel Rico, Joost H A Martens, Willem H Ouwehand, Taco W Kuijpers, Dirk S Paul, Hendrik G Stunnenberg, Oliver Stegle, Kate Downes, Tomi Pastinen, Nicole Soranzo
Characterizing the multifaceted contribution of genetic and epigenetic factors to disease phenotypes is a major challenge in human genetics and medicine. We carried out high-resolution genetic, epigenetic, and transcriptomic profiling in three major human immune cell types (CD14(+) monocytes, CD16(+) neutrophils, and naive CD4(+) T cells) from up to 197 individuals. We assess, quantitatively, the relative contribution of cis-genetic and epigenetic factors to transcription and evaluate their impact as potential sources of confounding in epigenome-wide association studies...
November 17, 2016: Cell
https://www.readbyqxmd.com/read/27766453/use-of-complementary-and-alternative-medicine-and-breast-cancer-survival-in-the-health-eating-activity-and-lifestyle-study
#3
Marian L Neuhouser, Ashley Wilder Smith, Stephanie M George, James T Gibson, Kathy B Baumgartner, Richard Baumgartner, Catherine Duggan, Leslie Bernstein, Anne McTiernan, Rachel Ballard
PURPOSE: Use of complementary and alternative medicine (CAM) is common among breast cancer patients, but less is known about whether CAM influences breast cancer survival. METHODS: Health Eating, Activity, and Lifestyle (HEAL) Study participants (n = 707) were diagnosed with stage I-IIIA breast cancer. Participants completed a 30-month post-diagnosis interview including questions on CAM use (natural products such as dietary and botanical supplements, alternative health practices, and alternative medical systems), weight, physical activity, and comorbidities...
October 21, 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27759681/beyond-the-cyst-the-many-contributions-of-isadore-tarlov-1905-1977-to-contemporary-neurosurgical-practice
#4
Anand Kaul, Sunil Manjila, Jonathan P Miller
: Isadore Max Tarlov (1905-1977) is primarily remembered for his 1938 description of the eponymous perineural "Tarlov cyst." However, during his long career as a neurosurgeon and researcher, he was responsible for many other observations and inventions that influenced the development of neurosurgery in the 20th century. While studying at Johns Hopkins Medical School he was acquainted with Walter Dandy, and he became the first resident to study under Wilder Penfield at the newly formed Montreal Neurological Institute...
November 2016: Neurosurgery
https://www.readbyqxmd.com/read/27591707/peer-review-and-wilderness-environmental-medicine
#5
EDITORIAL
Neal W Pollock
No abstract text is available yet for this article.
September 2016: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/27398732/abstracts-7-th-world-congress-of-mountain-wilderness-medicine-a-combined-meeting-of-the-international-society-for-mountain-medicine-and-the-wilderness-medical-society-july-30-august-4-2016-telluride-colorado
#6
https://www.readbyqxmd.com/read/26998708/changes-in-prescription-and-over-the-counter-medication-and-dietary-supplement-use-among-older-adults-in-the-united-states-2005-vs-2011
#7
Dima M Qato, Jocelyn Wilder, L Philip Schumm, Victoria Gillet, G Caleb Alexander
IMPORTANCE: Prescription and over-the-counter medicines and dietary supplements are commonly used, alone and together, among older adults. However, the effect of recent regulatory and market forces on these patterns is not known. OBJECTIVES: To characterize changes in the prevalence of medication use, including concurrent use of prescription and over-the-counter medications and dietary supplements, and to quantify the frequency and types of potential major drug-drug interactions...
April 2016: JAMA Internal Medicine
https://www.readbyqxmd.com/read/26948555/medical-knowledge-and-preparedness-of-climbers-on-colorado-s-14-000-foot-peaks
#8
William E Brandenburg, Christopher B Davis
OBJECTIVE: To assess the medical knowledge and preparedness of mountain climbers on Colorado's 14,000-foot peaks and to compare differences in knowledge and preparedness based on demographics, training, and difficulty of the climb. METHODS: Mountain climbers from 11 14,000-foot peaks in Colorado were surveyed at the time of summiting. These peaks represented every major mountain range and class of difficulty in Colorado. Marijuana use and demographic information including age, gender, state of residence, and income level was collected in the survey...
March 2016: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/26948550/2015-wilderness-environmental-medicine-peer-reviewers
#9
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
March 2016: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/26900118/wilderness-medicine
#10
REVIEW
Whitney Alexander, Steven Bright, Patrick Burns, David Townes
Wilderness medicine encompasses prevention and treatment of illness and injury, education and training, emergency medical services, and search and rescue in the wilderness. Although traumatic injuries, including minor injuries, outnumber medical illness as the cause of morbidity in the wilderness, basic understanding of the prevention and management of injury and illness, including recognition, identification, treatment, initial management, and stabilization, is essential, in addition to the ability to facilitate evacuation of affected patients...
March 2016: Medical Clinics of North America
https://www.readbyqxmd.com/read/26857731/otologic-hazards-related-to-scuba-diving
#11
Tiffany A Glazer, Steven A Telian
CONTEXT: As of 2015, more than 23 million scuba diver certifications have been issued across the globe. Given the popularity of scuba diving, it is incumbent on every physician to know and understand the specific medical hazards and conditions associated with scuba diving. EVIDENCE ACQUISITION: Sources were obtained from PubMed, MEDLINE, and EBSCO databases from 1956 onward and ranged from diverse fields including otologic reviews and wilderness medicine book chapters...
March 2016: Sports Health
https://www.readbyqxmd.com/read/26844930/structural-re-engineering-of-the-%C3%AE-helix-mimetic-jy-1-106-into-small-molecules-disruption-of-the-mcl-1-bak-bh3-protein-protein-interaction-with-2-6-di-substituted-nicotinates
#12
Brandon Drennen, Jacob A Scheenstra, Jeremy L Yap, Lijia Chen, Maryanna E Lanning, Braden M Roth, Paul T Wilder, Steven Fletcher
The disruption of aberrant protein-protein interactions (PPIs) with synthetic agents remains a challenging goal in contemporary medicinal chemistry but some progress has been made. One such dysregulated PPI is that between the anti-apoptotic Bcl-2 proteins, including myeloid cell leukemia-1 (Mcl-1), and the α-helical Bcl-2 homology-3 (BH3) domains of its pro-apoptotic counterparts, such as Bak. Herein, we describe the discovery of small-molecule inhibitors of the Mcl-1 oncoprotein based on a novel chemotype...
April 19, 2016: ChemMedChem
https://www.readbyqxmd.com/read/26738718/extreme-expedition-and-wilderness-medicine
#13
REVIEW
Christopher H E Imray, Michael P W Grocott, Mark H Wilson, Amy Hughes, Paul S Auerbach
Extreme, expedition, and wilderness medicine are modern and rapidly evolving specialties that address the spirit of adventure and exploration. The relevance of and interest in these specialties are changing rapidly to match the underlying activities, which include global exploration, adventure travel, and military deployments. Extreme, expedition, and wilderness medicine share themes of providing best available medical care in the outdoors, especially in austere or remote settings. Early clinical and logistics decision making can often have important effects on subsequent outcomes...
December 19, 2015: Lancet
https://www.readbyqxmd.com/read/26634559/high-altitude-pulmonary-edema-and-hypoxia-related-genes-genet-mol-res-14-3-11562-11572-correlation-between-single-nucleotide-polymorphisms-in-hypoxia-related-genes-and-susceptibility-to-acute-high-altitude-pulmonary-edema
#14
LETTER
https://www.readbyqxmd.com/read/26629337/faculty-of-prehospital-care-royal-college-of-surgeons-edinburgh-guidance-for-medical-provision-for-wilderness-medicine
#15
Adrian Mellor, Naomi Dodds, Raj Joshi, John Hall, Sundeep Dhillon, Sarah Hollis, Pete Davis, David Hillebrandt, Eva Howard, Matthew Wilkes, Burjor Langdana, David Lee, Nigel Hinson, Thomas Harcourt Williams, Joe Rowles, Harvey Pynn
To support leaders and those involved in providing medical care on expeditions in wilderness environments, the Faculty of Pre-Hospital Care (FPHC) of The Royal College of Surgeons of Edinburgh convened an expert panel of leading healthcare professionals and expedition providers. The aims of this panel were to: (1) provide guidance to ensure the best possible medical care for patients within the geographical, logistical and human factor constraints of an expedition environment. (2) Give aspiring and established expedition medics a 'benchmark' of skills they should meet...
2015: Extreme Physiology & Medicine
https://www.readbyqxmd.com/read/26617382/wilderness-preparticipation-evaluation-and-considerations-for-special-populations
#16
REVIEW
Elizabeth Joy, Karin Van Baak, Katherine L Dec, Barbara Semakula, Ashlea D Cardin, Jay Lemery, George C Wortley, Michael Yaron, Christopher Madden
Children, older adults, disabled and special needs athletes, and female athletes who participate in outdoor and wilderness sports and activities each face unique risks. For children and adolescents traveling to high altitude, the preparticipation physical evaluation should focus on risk assessment, prevention strategies, early recognition of altitude-related symptoms, management plans, and appropriate follow-up. As the risk and prevalence of chronic disease increases with age, both older patients and providers need to be aware of disease and medication-specific risks relative to wilderness sport and activity participation...
December 2015: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/26617377/preparticipation-evaluation-for-climbing-sports
#17
REVIEW
Aaron D Campbell, Christopher Davis, Ryan Paterson, Tracy A Cushing, Pearlly Ng, Charles S Peterson, Peter E Sedgwick, Scott E McIntosh
Climbing is a popular wilderness sport among a wide variety of professional athletes and amateur enthusiasts, and many styles are performed across many environments. Potential risks confront climbers, including personal health or exacerbation of a chronic condition, in addition to climbing-specific risks or injuries. Although it is not common to perform a preparticipation evaluation (PPE) for climbing, a climber or a guide agency may request such an evaluation before participation. Formats from traditional sports PPEs can be drawn upon, but often do not directly apply...
December 2015: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/26617373/ethical-legal-and-administrative-considerations-for-preparticipation-evaluation-for-wilderness-sports-and-adventures
#18
REVIEW
Craig C Young, Aaron D Campbell, Jay Lemery, David S Young
Preparticipation evaluations (PPEs) are common in team, organized, or traditional sports but not common in wilderness sports or adventures. Regarding ethical, legal, and administrative considerations, the same principles can be used as in traditional sports. Clinicians should be trained to perform such a PPE to avoid missing essential components and to maximize the quality of the PPE. In general, participants' privacy should be observed; office-based settings may be best for professional and billing purposes, and adequate documentation of a complete evaluation, including clearance issues, should be essential components...
December 2015: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/26507611/coca-high-altitude-remedy-of-the-ancient-incas
#19
Amy Sue Biondich, Jeremy D Joslin
The use of coca leaf for medicinal purposes is a centuries-old tradition of the native peoples of South America. Coca products are thought by many laypersons to provide risk-free benefits to users participating in strenuous activities at high altitude. Physiologic studies of coca have increased understanding of its possible mechanism of action as well as its potential impact on high altitude activities. This present work explores the role of coca throughout the history of the Andean peoples and explores whether this ancient remedy has a place in modern medicine...
December 2015: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/26445563/wilderness-medicine-at-high-altitude-recent-developments-in-the-field
#20
REVIEW
Neeraj M Shah, Sidra Hussain, Mark Cooke, John P O'Hara, Adrian Mellor
Travel to high altitude is increasingly popular. With this comes an increased incidence of high-altitude illness and therefore an increased need to improve our strategies to prevent and accurately diagnose these. In this review, we provide a summary of recent advances of relevance to practitioners who may be advising travelers to altitude. Although the Lake Louise Score is now widely used as a diagnostic tool for acute mountain sickness (AMS), increasing evidence questions the validity of doing so, and of considering AMS as a single condition...
2015: Open Access Journal of Sports Medicine
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