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fusidic acid

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https://www.readbyqxmd.com/read/28073733/antibiotic-therapy-and-staphylococcal-skin-infections-in-a-tropical-malarial-zone-guyana-practices-in-conventional-and-exceptional-situations
#1
S-P Corcostegui, H Lefort, A Dia, V Pommier de Santi, C Carfantan, J Galant, E Lightburne, P Guénot, X Deparis, R Migliani, J-J Morand
A problem of community-acquired Staphylococcus aureus skin infections emerged in the French armed forces in 2004, in a malaria-endemic areas. The high incidence rate led us to evaluate military staff practices. This was a cross-sectional survey of doctors and nurses deployed as officers in French Guyana since 2006. The definition of skin and soft-tissue infection came from the criteria for epidemiological surveillance of the armed forces. We studied the management of antibiotic therapy and its related difficulties...
November 1, 2016: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/28062288/designation-of-pathogenic-resistant-bacteria-in-the-sparusaurata-sea-collected-in-tunisia-coastlines-correlation-with-high-performance-liquid-chromatography-tandem-mass-spectrometry-analysis-of-antibiotics
#2
Amina Zouiten, Ines Mehri, Asma Beltifa, Asma Ghorbel, Olivier Sire, Joris Van Loco, Hassen Abdenaceur, Tim Reyns, Hedi Ben Mansour
Vibrio is characterized by a large number of species and some of them are human pathogens causing gastro intestinal and wound infections through the ingestion or manipulation of contaminated fishes including Vibrio parahaemolyticus and Vibrio alginolyticus. In this study, we reported the phenotypic and molecular characterization of Vibrio parahaemolyticus and Vibrio alginolyticus strains isolated from wild and farm sea bream (Sparus aurata L.) along the Tunisian coast from December 2015 to April 2016. Therefore, the antibiograms indicate a difference between farmed and wild fish...
January 3, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28060920/the-tir-homologue-lies-near-resistance-genes-in-staphylococcus-aureus-coupling-modulation-of-virulence-and-antimicrobial-susceptibility
#3
Sabine Patot, Paul Rc Imbert, Jessica Baude, Patricia Martins Simões, Jean-Baptiste Campergue, Arthur Louche, Reindert Nijland, Michèle Bès, Anne Tristan, Frédéric Laurent, Adrien Fischer, Jacques Schrenzel, François Vandenesch, Suzana P Salcedo, Patrice François, Gérard Lina
Toll/interleukin-1 receptor (TIR) domains in Toll-like receptors are essential for initiating and propagating the eukaryotic innate immune signaling cascade. Here, we investigate TirS, a Staphylococcus aureus TIR mimic that is part of a novel bacterial invasion mechanism. Its ectopic expression in eukaryotic cells inhibited TLR signaling, downregulating the NF-kB pathway through inhibition of TLR2, TLR4, TLR5, and TLR9. Skin lesions induced by the S. aureus knockout tirS mutant increased in a mouse model compared with wild-type and restored strains even though the tirS-mutant and wild-type strains did not differ in bacterial load...
January 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28012840/synthesis-and-biological-characterisation-of-ester-and-amide-derivatives-of-fusidic-acid-as-antiplasmodial-agents
#4
Marlene Espinoza-Moraga, Kawaljit Singh, Mathew Njoroge, Gurminder Kaur, John Okombo, Carmen De Kock, Peter J Smith, Sergio Wittlin, Kelly Chibale
A series of novel fusidic acid (FA) derivatives was synthesized by replacing the carboxylic acid group with various ester and amide groups and evaluated in vitro for their antiplasmodial activity against the chloroquine-sensitive NF54 and multidrug-resistant K1 strains of the malarial parasite Plasmodium falciparum. Most of these derivatives showed a 4-49 and 5-17-fold increase in activity against NF54 and KI strains, respectively, as compared to FA and had a good selectivity index. These derivatives are stable over the incubation period and do not appear to be prodrugs of fusidic acid...
November 25, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27999423/characterization-of-community-associated-staphylococcus-aureus-from-skin-and-soft-tissue-infections-a-multicenter-study-in-china
#5
Ying Liu, Zhe Xu, Zhou Yang, Juan Sun, Lin Ma
We evaluated the epidemiological and molecular features of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) and methicillin-sensitive S. aureus (MSSA) from children and adult patients with skin and soft-tissue infections (SSTIs) in China. Prospective community-acquired S. aureus SSTI surveillance was conducted in 23 hospitals over a 24-month period. Susceptibility to 16 antimicrobials was evaluated using the agar dilution method. StatApriori was used to determine statistically significant association trends...
December 21, 2016: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/27982032/transport-of-lipophilic-carboxylates-is-mediated-by-transmembrane-helix-2-in-multidrug-transporter-acrb
#6
Christine Oswald, Heng-Keat Tam, Klaas M Pos
The deployment of multidrug efflux pumps is a powerful defence mechanism for Gram-negative bacterial cells when exposed to antimicrobial agents. The major multidrug efflux transport system in Escherichia coli, AcrAB-TolC, is a tripartite system using the proton-motive force as an energy source. The polyspecific substrate-binding module AcrB uses various pathways to sequester drugs from the periplasm and outer leaflet of the inner membrane. Here we report the asymmetric AcrB structure in complex with fusidic acid at a resolution of 2...
December 16, 2016: Nature Communications
https://www.readbyqxmd.com/read/27981857/effective-modified-conservative-tissue-preserving-protocol-to-treat-stage-i-axillary-hidradenitis-suppurativa-a-prospective-cohort-study-of-627-patients-with-five-years-follow-up
#7
Bader Hamza Shirah, Hamza Asaad Shirah
BACKGROUND: Hidradenitis suppurativa is a chronic inflammatory cutaneous disorder that involves the infundibular terminal follicles in areas rich in apocrine glands and associated with the formation of abscesses and fistulating sinus. The clinical course is variable, and definitive evidence-based guidelines for the management are not well-established. Conservative treatment is controversial, and surgical excision is the recommended method. Herein, we aim to analyze the results of a modified conservative tissue preserving management protocol for stage I axillary hidradenitis suppurativa...
December 16, 2016: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/27908697/clostridium-difficile-carriage-in-adult-cystic-fibrosis-cf-implications-for-patients-with-cf-and-the-potential-for-transmission-of-nosocomial-infection
#8
D G Burke, M J Harrison, C Fleming, M McCarthy, C Shortt, I Sulaiman, D M Murphy, J A Eustace, F Shanahan, C Hill, C Stanton, M C Rea, R P Ross, B J Plant
Clostridium difficile is an anaerobic Gram-positive, spore-forming, toxin-producing bacillus transmitted among humans through the faecal-oral route. Despite increasing carriage rates and the presence of C. difficile toxin in stool, patients with CF rarely appear to develop typical manifestations of C. difficile infection (CDI). In this study, we examined the carriage, toxin production, ribotype distribution and antibiotic susceptibility of C. difficile in a cohort of 60 adult patients with CF who were pre-lung transplant...
November 29, 2016: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/27903884/real-time-determination-of-bacterial-in-vivo-ribosome-translation-elongation-speed-based-on-lacz%C3%AE-complementation-system
#9
Manlu Zhu, Xiongfeng Dai, Yi-Ping Wang
Bacterial growth significantly depends on protein synthesis catalyzed by ribosome. Ribosome translation elongation speed is a key factor determining the bacterial protein synthesis rate. However, existing methods for determining translation elongation speed have limited applications. Here we developed a simple and convenient method for measuring bacterial translation elongation speed based on LacZα complementation system. It enables the measurement of in vivo translation elongation speed of different individual genes...
November 16, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27902273/racemicystis-persica-sp-nov-a-novel-myxobacterium-from-iranian-soil
#10
Joachim Wink, Azam Moradi, Gholam Hosein Ebrahimipour, Kathrin Mohr, Peter Kämpfer, Stefanie Glaeser, Fabienne Hennessen, Katja Gemperlein, Awal Prasad Ram, Corinna Wolf, Rolf Müller
A novel myxobacterium, strain MSr11462T, was isolated in 2015 from a soil sample collected from Kish Island beach, Persian Gulf, Iran. It displayed general myxobacterial features like Gram negative staining, rod shaped vegetative cells, gliding on solid surfaces, microbial lytic activity, fruiting body like aggregates and myxospore like structures. The strain was mesophilic, aerobic and showed chemoheterotrophic mode of nutrition. It was resistant to many antibiotics like gentamycin, polymyxin, Fusidic acid and trimethopril and the key fatty acids of whole cell hydrolysates were iso-C15:0, C16:0, iso-C17:0, C18:1 , iso-C17:1 2-OH, C18:1 2-OH, iso-C15:0 OAG (O-alkylglycerol), and C16:1 OAG...
November 11, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27896620/antimicrobial-activity-of-topical-agents-against-propionibacterium-acnes-an-in-vitro-study-of-clinical-isolates-from-a-hospital-in-shanghai-china
#11
Ying Ma, Nanxue Zhang, Shi Wu, Haihui Huang, Yanpei Cao
This study aimed to compare the antimicrobial activities of topical agents against Propionibacterium acnes isolated from patients admitted to a hospital in Shanghai, China. The minimal inhibitory concentrations of the cultured P. acnes were determined in accordance with the Clinical and Laboratory Standards Institute. Susceptibilities to clindamycin and erythromycin were compared in terms of gender, age, disease duration, previous treatment, and disease severity. A total of 69 P. acnes strains were isolated from 98 patients (70...
November 28, 2016: Frontiers of Medicine
https://www.readbyqxmd.com/read/27891157/the-in-vitro-antimicrobial-effects-of-lavandula-angustifolia-essential-oil-in-combination-with-conventional-antimicrobial-agents
#12
Stephanie de Rapper, Alvaro Viljoen, Sandy van Vuuren
The paper focuses on the in vitro antimicrobial activity of Lavandula angustifolia Mill. (lavender) essential oil in combination with four commercial antimicrobial agents. Stock solutions of chloramphenicol, ciprofloxacin, nystatin, and fusidic acid were tested in combination with L. angustifolia essential oil. The antimicrobial activities of the combinations were investigated against the Gram-positive bacterial strain Staphylococcus aureus (ATCC 6538) and Gram-negative Pseudomonas aeruginosa (ATCC 27858) and Candida albicans (ATCC 10231) was selected to represent the yeasts...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27846898/antibiotics-in-malaria-therapy-which-antibiotics-except-tetracyclines-and-macrolides-may-be-used-against-malaria
#13
REVIEW
Tiphaine Gaillard, Marylin Madamet, Francis Foguim Tsombeng, Jérôme Dormoi, Bruno Pradines
Malaria, a parasite vector-borne disease, is one of the most significant health threats in tropical regions, despite the availability of individual chemoprophylaxis. Malaria chemoprophylaxis and chemotherapy remain a major area of research, and new drug molecules are constantly being developed before drug-resistant parasites strains emerge. The use of anti-malarial drugs is challenged by contra-indications, the level of resistance of Plasmodium falciparum in endemic areas, clinical tolerance and financial cost...
November 15, 2016: Malaria Journal
https://www.readbyqxmd.com/read/27828633/staphylococcus-aureus-resistance-to-topical-antimicrobials-in-atopic-dermatitis
#14
Giancarlo Rezende Bessa, Vanessa Petry Quinto, Daiane Corrêa Machado, Caroline Lipnharski, Magda Blessmann Weber, Renan Rangel Bonamigo, Pedro Alves D'Azevedo
Background: Topical antimicrobial drugs are indicated for limited superficial pyodermitis treatment, although they are largely used as self-prescribed medication for a variety of inflammatory dermatoses, including atopic dermatitis. Monitoring bacterial susceptibility to these drugs is difficult, given the paucity of laboratory standardization. Objective: To evaluate the prevalence of Staphylococcus aureus topical antimicrobial drug resistance in atopic dermatitis patients...
September 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/27813241/population-pharmacokinetics-of-rifampicin-in-adult-patients-with-osteoarticular-infections-interaction-with-fusidic-acid
#15
A Marsot, A Ménard, J Dupouey, C Muziotti, R Guilhaumou, O Blin
AIMS: Rifampicin represents the key antibiotic for management of osteoarticular infections. An important pharmacokinetic variability has already been described, incriminating notably absorption and metabolism. All previous pharmacokinetic studies were only focused on patient treated for tuberculosis. The objective of this study was to describe a population pharmacokinetic model of rifampicin in patients with staphylococcal osteoarticular infections, data which have not been investigated to date...
November 4, 2016: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27793509/toxin-profiles-pcr-ribotypes-and-resistance-patterns-of-clostridium-difficile-a-multicentre-study-in-china-2012-2013
#16
Qiong Gao, Shi Wu, Haihui Huang, Yuxing Ni, Ye Chen, Yunjian Hu, Yunsong Yu
A total of 178 clinical isolates of Clostridium difficile were collected from five major teaching hospitals representing northern, eastern and southern China from August 2012 to July 2013. Among the 178 isolates, 162 (91.0%) were toxigenic, including 66 (40.7%) toxin A-negative, toxin B-positive, 95 (58.6%) toxin A-positive, toxin B-positive and only 1 (0.6%) toxin A-, toxin B- and binary toxin-positive. Twenty-nine different PCR ribotypes were identified, of which 017 (21.0%), 012 (17.3%) and novel type H (16...
December 2016: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/27755189/a-10-year-review-of-ocular-methicillin-resistant-staphylococcus-aureus-infections-epidemiology-clinical-features-and-treatment
#17
Emily S Wong, Claire W Y Chow, W K Luk, Kitty S C Fung, Kenneth K W Li
PURPOSE: To characterize epidemiological data on methicillin-resistant Staphylococcus aureus (MRSA) ocular infections over a 10-year period in Hong Kong; to compare the characteristics between hospital-associated methicillin-resistant Staphylococcus aureus (h-MRSA) and community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) ocular infections; and to review the treatment regimen and outcome of identified cases. METHODS: A retrospective case review of ocular samples testing positive for MRSA at a tertiary eye center from July 2005 to June 2015 was performed...
January 2017: Cornea
https://www.readbyqxmd.com/read/27736855/where-to-from-here-the-treatment-of-impetigo-in-children-as-resistance-to-fusidic-acid-emerges
#18
Alison Vogel, Diana Lennon, Emma Best, Alison Leversha
Admissions for skin and soft-tissue infections have been increasing steadily in children and in the general population. Concerns have been raised recently about the increasing widespread use of topical fusidic acid and concurrent increase of fusidic acid-resistant Staphylococcus aureus. Fusidic acid resistance and methicillin resistant Staphylococcus aureus (MRSA) are both more prevalent in youngest age group (<5 year-olds) and particularly in the North island. In New Zealand, fusidic acid is recommended for treatment of minor impetigo and is the only fully-funded topical antibiotic...
October 14, 2016: New Zealand Medical Journal
https://www.readbyqxmd.com/read/27730175/mrsa-eradication-of-newly-acquired-lower-respiratory-tract-infection-in-cystic-fibrosis
#19
Emilie Vallières, Jacqueline C Rendall, John E Moore, John McCaughan, Anne I Hoeritzauer, Michael M Tunney, Joseph Stuart Elborn, Damian G Downey
UK cystic fibrosis (CF) guidelines recommend eradication of methicillin-resistant Staphylococcus aureus (MRSA) when cultured from respiratory samples. As there is no clear consensus as to which eradication regimen is most effective, we determined the efficacy of eradication regimens used in our CF centre and long-term clinical outcome. All new MRSA positive sputum cultures (n=37) that occurred between 2000 and 2014 were reviewed. Eradication regimen characteristics and clinical, microbiological and long-term outcome data were collected...
January 2016: ERJ Open Research
https://www.readbyqxmd.com/read/27729132/what-are-the-leading-causative-pathogens-in-acute-otitis-media-with-tympanic-membrane-perforation
#20
Nuntigar Sonsuwan, Patcharin Watcharinyanon, Kittisak Sawanyawisuth
OBJECTIVES: Acute otitis media (AOM) is a common infectious disease in children. Data regarding the distribution of causative pathogens are not universal. Tympanic perforation due to AOM may occur in 5-30% of AOM patients. The causative pathogens for AOM with tympanic perforation are limited. METHODS: This was a prospective study conducted at the Department of Otolaryngology, Faculty of Medicine, Chiang Mai University, Thailand. All consecutive children diagnosed as having AOM with tympanic perforation were enrolled...
November 2016: International Journal of Pediatric Otorhinolaryngology
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