keyword
MENU ▼
Read by QxMD icon Read
search

fusidic acid

keyword
https://www.readbyqxmd.com/read/29782305/tatami-mats-a-source-of-pitted-keratolysis-in-a-martial-arts-athlete
#1
Anamaria Balić, Zrinka Bukvić Mokos, Branka Marinović, Daniela Ledić Drvar
Dear Editor, Pitted keratolysis (PK), also known as keratosis plantaris sulcatum, is a non-inflammatory, bacterial, superficial cutaneous infection, characterized by many discrete superficial crateriform ''pits'' and erosions in the thickly keratinized skin of the weight-bearing regions of the soles of the feet (1). The disease often goes unnoticed by the patient, but when it is noticed it is because of the unbearable malodor and hyperhidrosis of the feet, which are socially unacceptable and cause great anxiety to many of the patients...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29729180/the-widespread-use-of-topical-antimicrobials-enriches-for-resistance-in-staphylococcus-aureus-isolated-from-atopic-dermatitis-patients
#2
C P Harkins, M A McAleer, D Bennett, M McHugh, O M Fleury, K A Pettigrew, K Oravcová, J Parkhill, C M Proby, R S Dawe, J A Geoghegan, A D Irvine, M T G Holden
BACKGROUND: Carriage rates of Staphylococcus aureus on affected skin in atopic dermatitis (AD) are approximately 70%. Increasing disease severity during flares and overall disease severity correlate with increased burden of S. aureus. Treatment in AD therefore often targets S. aureus, with topical and systemic antimicrobials. OBJECTIVES: To determine if antimicrobial sensitivities and genetic determinants of resistance differed in S. aureus isolates from the skin of children with AD compared with healthy child nasal carriers...
May 5, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29713630/novel-antimicrobials-for-the-treatment-of-clostridium-difficile-infection
#3
REVIEW
Nicola Petrosillo, Guido Granata, Maria Adriana Cataldo
The current picture of Clostridium difficile infection (CDI) is alarming with a mortality rate ranging between 3% and 15% and a CDI recurrence rate ranging from 12% to 40%. Despite the great efforts made over the past 10 years to face the CDI burden, there are still gray areas in our knowledge on CDI management. The traditional anti-CDI antimicrobials are not always adequate in addressing the current needs in CDI management. The aim of our review is to give an update on novel antimicrobials for the treatment of CDI, considering the currently available evidences on their efficacy, safety, molecular mechanism of action, and their probability to be successfully introduced into the clinical practice in the near future...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29712650/activity-of-combinations-of-antistaphylococcal-antibiotics-with-fusidic-acid-against-staphylococcal-biofilms-in-in-vitro-static-and-dynamic-models
#4
Wafi Siala, Hector Rodriguez-Villalobos, Prabhavathi Fernandes, Paul M Tulkens, Françoise Van Bambeke
Staphylococcal biofilms are a major cause of therapeutic failure, especially when caused by multiresistant strains. Oral fusidic acid is currently being re-developed in the US for skin and skin structure and orthopedic infections, in which biofilms play a major role. The aim of this study was to examine the activity of fusidic acid alone or combined with other anti-staphylococcal drugs against biofilms made by a reference strain and five clinical isolates of Staphylococcus aureus or Staphylococcus epidermidis in in vitro static or dynamic models (microtiter plates and CDC reactor) exposed to clinically-relevant concentrations...
April 30, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29690500/microbial-oxidation-of-the-fusidic-acid-side-chain-by-cunninghamella-echinulata
#5
Abdel-Rahim S Ibrahim, Khaled M Elokely, Daneel Ferreira, Amany E Ragab
Biotransformation of fusidic acid ( 1 ) was accomplished using a battery of microorganisms including Cunninghamella echinulata NRRL 1382, which converted fusidic acid ( 1 ) into three new metabolites 2 ⁻ 4 and the known metabolite 5 . These metabolites were identified using 1D and 2D NMR and HRESI-FTMS data. Structural assignment of the compounds was supported via computation of ¹H- and 13 C-NMR chemical shifts. Compounds 2 and 3 were assigned as the 27-hydroxy and 26-hydroxy derivatives of fusidic acid, respectively...
April 21, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29686771/oral-wound-healing-effects-of-acai-berry-water-extracts-in-rat-oral-mucosa
#6
Mi Hyun Kang, Bae-Hwan Kim
The objective of this study was to determine the oral wound healing effects of acai berry water extracts (ABWE) in rat oral mucosa. To estimate the anti-oxidative effects of ABWE, the contents of phenolic compounds, and DPPH (1,1-diphenyl-2-picryl hydrazyl) and ABTS (2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid)) abilities were evaluated. Wound healing effects of ABWE were tested following 6-day exposure after induction of wound by applying 50% acetic acid to oral mucosa of Sprague-Dawley rats. Macroscopic and histopathological analyses were performed to determine wound healing effects of ABWE...
April 2018: Toxicological Research
https://www.readbyqxmd.com/read/29683776/coagulase-negative-staphylococci-isolated-from-human-bloodstream-infections-showed-multidrug-resistance-profile
#7
Silvia H S P Pedroso, Savio H C Sandes, Robledo A T Filho, Alvaro C Nunes, Jose C Serufo, Luiz M Farias, Maria A R Carvalho, Maria R Q Bomfim, Simone G Santos
Coagulase-negative staphylococci (CNS) are important pathogens causing nosocomial infections worldwide with increasing resistance to antimicrobials. The aim of this study was to characterize resistance aspects of CNS isolated from patients with bloodstream infections acquired in hospitals in Belo Horizonte, MG, Brazil. Staphylococcus strains were characterized using repetitive sequence-based polymerase chain reaction (rep-PCR) fingerprinting with (GTG)5 primer. Phenotypic resistance was analyzed using AST-P5085 card (bioMérieuxVitek® )...
April 23, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29680503/chitosan-tailored-lipidic-nanoconstructs-of-fusidic-acid-as-promising-vehicle-for-wound-infections-an-explorative-study
#8
Kanika Thakur, Gajanand Sharma, Bhupinder Singh, Sanjay Chhibber, A B Patil, Om Prakash Katare
The current research study intends to explore the combined potential of lipid nanoparticles and chitosan as an optimum therapy for the management of wound infections. Fusidic acid (FA), a steroidal antibiotic employed for treatment of primary and secondary topical infections was encapsulated within the nanoengineered lipid-polymer hybrid nanoparticles (FA-LPHNs). A number of variables like lipid/polymer ratio, lipid, surfactant and chitosan concentration, stirring speed were optimized to get the desired particle size and % entrapment efficiency...
April 19, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29668723/emerging-variants-of-methicillin-resistant-staphylococcus-aureus-genotypes-in-kuwait-hospitals
#9
Samar S Boswihi, Edet E Udo, Stefan Monecke, Bindu Mathew, Bobby Noronha, Tina Verghese, Sajida B Tappa
BACKGROUND: Frequent changes in the epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) occurring worldwide demand regular surveillance to study their composition and distribution in healthcare facilities. We investigated the genotypic characteristics of MRSA obtained in Kuwait hospitals to better understand their clonal distribution. MATERIALS AND METHODS: A total of 1,327 MRSA isolates obtained from clinical samples in 13 Kuwait hospitals from 1 January to 31 December 2016 were investigated using antibiogram, SCCmec typing, spa typing and DNA microarray...
2018: PloS One
https://www.readbyqxmd.com/read/29663126/antibiotic-resistance-profiles-of-coagulase-positive-and-coagulase-negative-staphylococci-from-pit-latrine-fecal-sludge-in-a-peri-urban-south-african-community
#10
Lorika S Beukes, Stefan Schmidt
The aim of this study was to assess pit latrine samples from a peri-urban community in KwaZulu-Natal (South Africa) for the presence of multidrug-resistant (MDR) Staphylococcus spp. Standard procedures were used to isolate Staphylococcus spp. from pit latrine fecal sludge samples, with confirmation at genus level by polymerase chain reaction (PCR). Sixty-eight randomly selected pit latrine Staphylococcus spp. isolates were further characterized by using established disk diffusion procedures. An average Staphylococcus spp...
April 16, 2018: Folia Microbiologica
https://www.readbyqxmd.com/read/29621629/genetic-characterization-of-staphylococcus-aureus-isolated-from-milk-and-nasal-samples-of-healthy-cows-in-tunisia-first-report-of-st97-t267-agri-sccmecv-mrsa-of-bovine-origin-in-tunisia
#11
Monia Khemiri, Mohamed Salah Abbassi, Natacha Couto, Riadh Mansouri, Salah Hammami, Constança Pomba
OBJECTIVES: This study aimed to screen for and characterize methicillin-susceptible S. aureus (MSSA) and MRSA in nasal swabs and milk from healthy cows from different regions in Tunisia. METHODS: One hundred and forty-one Staphylococcus spp. isolates were recovered from milk and nasal swabs of cows. S. aureus isolates were further characterized by determining their antibiotic susceptibilities, genes encoding antibiotic resistance and virulence factors, biofilm production, agr type and PFGE...
April 2, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29618431/investigation-of-staphylococcus-aureus-prevailing-in-the-environment-of-khyber-teaching-hospital-peshawar-pakistan
#12
Farmanullah Khan, Bashir Ahmad, Jawad Ahmed, Han Sang Yoo, Shumaila Bashir
The hospital environment plays an important role in the spread of microorganisms, including multi drug resistant (MDR) strains. Patients can acquire Methicillin-Resistant Staphylococcus aureus (MRSA) which can reside in the clinical setup that are not cleaned and can spread through air droplets, bed clothing, and healthcare workers. The purpose of this study was to investigate the prevalence of S. aureus in the Khyber Teaching Hospital (KTH). A total of 200 samples were collected from the floor, walls, air and inanimate objects in different wards of the KTH, during May 2012 to September 2012...
March 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29599521/demographic-fluctuation-of-community-acquired-antibiotic-resistant-staphylococcus-aureus-lineages-potential-role-of-flimsy-antibiotic-exposure
#13
Claude-Alexandre Gustave, Anne Tristan, Patricia Martins-Simões, Marc Stegger, Yvonne Benito, Paal Skytt Andersen, Michèle Bes, Typhanie Le Hir, Binh An Diep, Anne-Catrin Uhlemann, Philippe Glaser, Frédéric Laurent, Thierry Wirth, François Vandenesch
Community-acquired (CA)- as opposed to hospital acquired- methicillin-resistant Staphylococcus aureus (MRSA) lineages arose worldwide during the 1990s. To determine which factors, including selective antibiotic pressure, govern the expansion of two major lineages of CA-MRSA, namely "USA300" in Northern America and "European ST80" in North Africa, Europe and Middle-East, we explored virulence factor expression, and fitness levels with or without antibiotics. The sampled strains were collected in a temporal window representing various steps of the epidemics, reflecting predicted changes in effective population size as inferred from whole-genome analysis...
March 29, 2018: ISME Journal
https://www.readbyqxmd.com/read/29577266/knowledge-attitudes-and-practices-regarding-methicillin-resistant-staphylococcus-aureus-mrsa-infection-control-and-nasal-mrsa-carriage-rate-among-dental-health-care-professionals
#14
Yeon-Jee Yoo, Eun-Jung Kwak, Kyung Muk Jeong, Seung-Ho Baek, Yoo Sang Baek
BACKGROUND: Dental health-care professionals (DHCPs) with nasal colonisation of methicillin-resistant Staphylococcus aureus (MRSA) can serve as a reservoir for MRSA transmission to others and be exposed to self-contamination with MRSA. Evaluating the knowledge, attitudes and actual practice of DHCPs is imperative for appropriate infection control. METHODS: Dentists, dental hygienists and dental technologists from Seoul National University Dental Hospital were recruited to participate in a cross-sectional survey and undergo nasal sampling of MRSA...
March 25, 2018: International Dental Journal
https://www.readbyqxmd.com/read/29528278/cationic-bilayered-nanoemulsion-of-fusidic-acid-an-investigation-on-eradication-of-methicillin-resistant-staphylococcus-aureus-33591-infection-in-burn-wound
#15
Kanika Thakur, Gajanand Sharma, Bhupinder Singh, Ashay Jain, Rajeev Tyagi, Sanjay Chhibber, Om P Katare
AIM: The aim of the current study was to investigate the therapeutic efficacy of cationic-charged bilayered nanoemulsion for topical delivery of fusidic acid in eradicating methicillin-resistant Staphylococcus aureus (MRSA) bacterial burn wound infection. MATERIALS & METHODS: The developed carriers were characterized for particle size, antibacterial activity, cell viability assay in HaCat cell lines, rheological profile, ex vivo and in vivo studies, namely, full thickness MRSA 33591 murine burn wound infection via topical route...
March 12, 2018: Nanomedicine
https://www.readbyqxmd.com/read/29516425/infections-after-photodynamic-therapy-in-condyloma-acuminatum-patients-incidence-and-management
#16
Xin Yu, Heyi Zheng
Condyloma acuminatum (CA), or genital wart, is a sexually transmitted infection caused by human papillomaviruses. Increasing evidences demonstrated that photodynamic therapy (PDT) is effective in eliminating latent HPV infection, the major reason for CA recurrence. We observed an increasing number of infections after PDT in CA patients, which has not been reported before. This study aims to evaluate the incidence and management of infection in CA patients after PDT procedure. CA patients received PDT from January 2015 to February 2016 at the outpatient setting...
March 7, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29483219/targeting-prpk-function-blocks-colon-cancer-metastasis
#17
Tatyana Zykova, Feng Zhu, Lei Wang, Haitao Li, Do Young Lim, Ke Yao, Eunmiri Roh, Sang-Pil Yoon, Hong-Gyum Kim, Ki Beom Bae, Weihong Wen, Seung Ho Shin, Janos Nadas, Yan Li, Weiya Ma, Ann M Bode, Zigang Dong
The biological functions of the p53-related protein kinase (PRPK) remain unclear. We have previously demonstrated that PRPK is phosphorylated by the T-LAK cell-originated protein kinase (TOPK) and that phosphorylated PRPK (p-PRPK) promotes colon cancer metastasis. Here, we analyzed colon adenocarcinomas from 87 patients and found that higher expression levels of p-PRPK were associated with later stages of metastatic dissemination (stage III and IV) as compared with earlier stages (stages I and II). Indeed, levels of p-PRPK were higher in metastatic versus malignant human colon adenocarcinomas...
May 2018: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29422820/decolonization-of-staphylococcus-aureus-in-patients-with-atopic-dermatitis-a-reason-for-increasing-resistance-to-antibiotics
#18
Izabela Błażewicz, Maciej Jaśkiewicz, Marta Bauer, Lidia Piechowicz, Roman J Nowicki, Wojciech Kamysz, Wioletta Barańska-Rybak
Introduction: Exacerbation of atopic dermatitis can be associated with bacterial infection. The skin of patients is colonized with Staphylococcus aureus in 90% of cases. An attempt has been made to demonstrate that eradication significantly reduces the severity of the disease. Studies indicate the efficacy of topical antibiotics, topical corticosteroids and calcineurin inhibitors. Due to increasing resistance to drugs and the defective antimicrobial peptide profile, decolonization is virtually impossible...
December 2017: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/29408956/the-structure-of-an-elongation-factor-g-ribosome-complex-captured-in-the-absence-of-inhibitors
#19
Kevin Macé, Emmanuel Giudice, Sophie Chat, Reynald Gillet
During translation's elongation cycle, elongation factor G (EF-G) promotes messenger and transfer RNA translocation through the ribosome. Until now, the structures reported for EF-G-ribosome complexes have been obtained by trapping EF-G in the ribosome. These results were based on use of non-hydrolyzable guanosine 5'-triphosphate (GTP) analogs, specific inhibitors or a mutated EF-G form. Here, we present the first cryo-electron microscopy structure of EF-G bound to ribosome in the absence of an inhibitor. The structure reveals a natural conformation of EF-G·GDP in the ribosome, with a previously unseen conformation of its third domain...
April 6, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29407274/wide-dissemination-of-sccfusc-in-fusidic-acid-resistant-coagulase-negative-staphylococci-and-implication-for-its-spreading-to-methicillin-resistant-s-aureus-in-taiwan
#20
Yu-Tzu Lin, Wei-Chun Hung, Jui-Chang Tsai, Kin Hong Leong, Hsiao-Jan Chen, Po-Ren Hsueh, Lee-Jene Teng
We examined the fusidic acid resistance determinants fusB, fusC, fusD, and fusF in coagulase-negative staphylococci (CoNS) clinical isolates. Among 208 resistant isolates, the fusB gene was the most common determinant in each species except in S. hominis subsp. hominis or in species carrying fusD or fusF. In S. hominis subsp. hominis, the fusC gene was the major determinant responsible for fusidic acid resistance. To understand the genetic context of fusC in S. hominis subsp. hominis, 31 fusC-positive S. hominis subsp...
January 30, 2018: International Journal of Antimicrobial Agents
keyword
keyword
32829
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"