keyword
MENU ▼
Read by QxMD icon Read
search

fusidic acid

keyword
https://www.readbyqxmd.com/read/28797802/antibiotic-susceptibilities-and-prevalence-of-methicillin-resistant-staphylococcus-aureus-mrsa-isolated-from-bovine-milk-in-pakistan
#1
Amjad Islam Aqib, Muhammad Ijaz, Aftab Ahmad Anjum, Muhammad Abdul Rauf Malik, Khalid Mehmood, Shahid Hussain Farooqi, Kashif Hussain
The study was designed to investigate bovine milk for prevalence of an emerging zoonotic pathogen Methicillin resistant Staphylococcus aureus (MRSA), and in-vitro therapeutic response of various antibiotics against MRSA. Nine hundred (900) milk samples were collected (half from cattle and half from buffalo) from private and public farms located in various tehsils of district Faisalabad, using the convenient sampling method. Milk samples were put to biochemical identification of Staphylococcus aureus and later oxacilline disk sensitivity testing for confirmation of MRSA...
August 7, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28759825/binding-free-energy-calculations-using-mmpb-gbsa-approaches-for-pamam-g4-drug-complexes-at-neutral-basic-and-acid-ph-conditions
#2
Alberto Martínez-Muñoz, Martiniano Bello, Aurelio Romero-Castro, Rolando Alberto Rodríguez-Fonseca, João Rodrigues, Víctor Armando Sánchez-Espinosa, José Correa-Basurto
Dendrimers are synthetic macromolecules with a highly-branched structure and high concentration of surface groups. Among dendrimers, Poly(amidoamine) (PAMAM) has received substantial attention as a novel drug carrier and delivery system. Depending on the generation and type of terminal groups, dendrimer toxicity could change and include cytotoxicity. Although PAMAM is water soluble, molecular modeling of the dendrimer-drug complex is considered challenging for exploring the conformational mobility of dendrimers and atomic specific interactions during the dendrimer-drug association...
July 19, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28746830/biophysical-characterization-of-e-coli-tolc-interaction-with-the-known-blocker-hexaamminecobalt
#3
A Gilardi, S P Bhamidimarri, M Brönstrup, U Bilitewski, R K R Marreddy, K M Pos, L Benier, P Gribbon, M Winterhalter, B Windshügel
BACKGROUND: The tripartite efflux pump AcrAB-TolC in E. coli is involved in drug resistance by transporting antibiotics out of the cell. The outer membrane protein TolC can be blocked by various cations, including hexaamminecobalt, thereby TolC represents a potential target for reducing antimicrobial resistance as its blockage may improve efficacy of antibiotics. METHODS: We utilized single channel electrophysiology measurements for studying TolC conductance in the absence and presence of the known TolC blocker hexaamminecobalt...
July 23, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28735049/in-vitro-activity-of-daptomycin-combinations-with-rifampicin-gentamicin-fosfomycin-and-fusidic-acid-against-mrsa-strains
#4
Gulseren Aktas, Sengul Derbentli
OBJECTIVES: Although new antimicrobial agents designed to treat infections with limited therapeutic options have been introduced in the past few years, resistant Gram positive cocci have continued to emerge and spread. Daptomycin is a cyclic lipopeptide antibiotic that has rapid bactericidal activity against broad spectrum of Gram positive bacteria, including methicillin resistant Staphylococcus aureus (MRSA). Antibiotics are sometimes used in combination in an attempt to prevent or delay the in vivo emergence of drug-resistant subpopulations of pathogenic organisms...
July 19, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28729209/clonal-spread-of-methicillin-resistant-staphylococcus-aureus-t6065-cc5-sccmecv-agrii-in-a-libyan-hospital
#5
Monia Khemiri, Ali Akrout Alhusain, Mohamed Salah Abbassi, Houyem El Ghaieb, Sofia Santos Costa, Adriana Belas, Constança Pomba, Salah Hammami
OBJECTIVES: The aim of this study was to characterize 32 MRSA isolates recovered from wound specimens of patients in a Hospital in Tripoli, Libya, during 2013. METHODS: MRSA isolates were characterized by determining their antibiotic susceptibilities, genes encoding antibiotic resistance and virulence factors, the SCCmec class, agr type, spa typing, PFGE and MLST. RESULTS: PFGE and MLST revealed that all isolates were clonal and belonged to the Clonal Complex 5 (CC5)...
July 17, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28712173/surgical-site-infection-in-orthopaedic-implants-and-its-common-bacteria-with-their-sensitivities-to-antibiotics-in-open-reduction-internal-fixation
#6
Muhammad Qaisar Shah, Muhammad Shoib Zardad, Alamzeb Khan, Sajjad Ahmed, Abdus Saboor Awan, Taj Mohammad
BACKGROUND: Surgical site infection in orthopaedic implants is a major problem, causing long hospital stay, cost to the patient and is a burden on health care facilities. It increases rate of nonunion, osteomyelitis, implant failure, sepsis, multiorgan dysfunction and even death. Surgical site infection is defined as pain, erythema, swelling and discharge from wound site. Surgical site infection in orthopaedic implants is more challenging to the treating orthopaedic surgeon as the causative organism is protected by a biofilm over the implant's surface...
January 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28685715/high-staphylococcus-epidermidis-colonization-and-impaired-permeability-barrier-in-facial-seborrheic-dermatitis
#7
Qian An, Meng Sun, Rui-Qun Qi, Li Zhang, Jin-Long Zhai, Yu-Xiao Hong, Bing Song, Hong-Duo Chen, Xing-Hua Gao
BACKGROUND: Seborrheic dermatitis (SD) is a common inflammatory skin condition. The etiology is unclear, although overgrowth of Malassezia on the skin has been suggested to cause SD. This study investigated whether colonization with Staphylococcus plays a role in facial SD, which was not well addressed previously. METHODS: The study was conducted from September 1, 2011 to February 20, 2012 in the First Hospital of China Medical University. In the first phase, the study evaluated the level of transepidermal water loss (TEWL) and the number of colony-forming units (CFU) of Staphylococcus in defined skin areas of SD patients who were human immunodeficiency virus (HIV) seropositive (HIV [+] SD [+] group, n = 13), classical SD (HIV [-] SD [+] group, n = 24) patients, HIV seropositive-non-SD (HIV [+] SD [-] group, n = 16) patients, and healthy volunteers (HIV [-] SD [-] group, n = 16)...
July 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28679522/next-generation-sequence-analysis-reveals-methicillin-resistance-transfer-to-a-methicillin-susceptible-staphylococcus-aureus-mssa-strain-that-subsequently-caused-a-methicillin-resistant-staphylococcus-aureus-mrsa-outbreak-a-descriptive-study
#8
Veronica Weterings, Thijs Bosch, Sandra Witteveen, Fabian Landman, Leo Schouls, Jan Kluytmans
Resistance to methicillin in Staphylococcus aureus is primarily caused by the mecA gene, which is carried on a mobile genetic element: the staphylococcal cassette chromosome mec (SCCmec). Horizontal transfer of this element is supposed to play an important factor in the emergence of new clones of methicillin-resistant Staphylococcus aureus (MRSA), but has been rarely observed in real-time.In 2012, an outbreak occurred involving a healthcare worker (HCW) and three patients all carrying a fusidic-acid resistant MRSA strain...
July 5, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28668467/identification-of-a-pvl-negative-sccmec-iva-sub-lineage-of-the-methicillin-resistant-staphylococcus-aureus-cc80-lineage-understanding-the-clonal-origin-of-ca-mrsa
#9
Sofie Marie Edslev, Henrik Torkil Westh, Paal Skytt Andersen, Robert Skov, Nobumichi Kobayashi, Mette Damkjær Bartels, Francois Vandenesh, Andreas Petersen, Peder Worning, Anders Rhod Larsen, Marc Stegger
OBJECTIVES: Community-acquired MRSA (CA-MRSA) isolates belonging to clonal complex 80 (CC80) are recognized as the European CA-MRSA. The prevailing European CA-MRSA clone carries a type IVc staphylococcal cassette chromosome mec (SCCmec) and expresses Panton-Valentine leukocidin (PVL). Recently, a significant increase of PVL-negative CC80 MRSA has been observed in Denmark. The aim of this study was to examine the genetics and the epidemiology of these, and to compare them to the European CA-MRSA clone in order to understand the emergence of PVL-negative CC80 MRSA...
June 28, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28652437/increased-resistance-of-skin-flora-to-antimicrobial-prophylaxis-in-patients-undergoing-hip-revision-arthroplasty
#10
Heinrich M L Mühlhofer, Lukas Deiss, Philipp Mayer-Kuckuk, Florian Pohlig, Norbert Harrasser, Ulrich Lenze, Hans Gollwitzer, Christian Suren, Peter Prodinger, Rüdiger VON Eisenhart-Rothe, Johannes Schauwecker
BACKGROUND/AIM: Prosthetic joint infection (PJI) remains a major complication after total joint replacement and is the primary indication for revision arthroplasty. Specifically, coagulase-negative Staphylococci (CNS) can cause low-grade infections. Despite the use of cephalosporin-based antimicrobial prophylaxis (AMP) and antiseptic treatment at the surgical site, evidence suggests that a significant number of cases of dermal CNS results in low-grade PJI. Thus, this study examined the bacterial colonization and resistance patterns at the surgical site...
July 2017: In Vivo
https://www.readbyqxmd.com/read/28646693/antibacterial-effect-of-genetically-engineered-bacteriophage-%C3%AF-ef11-%C3%AF-fl1c-%C3%AE-36-p-nisa-on-dentin-infected-with-antibiotic-resistant-enterococcus-faecalis
#11
Justine Monnerat Tinoco, Nadia Liss, Hongming Zhang, Roni Nissan, Wanda Gordon, Eduardo Tinoco, Luciana Sassone, Roy Stevens
OBJECTIVE: Enterococcus faecalis is a gram-positive facultative anaerobic bacterium, which is present in 30-89% of teeth with postendodontic treatment failures. E. faecalis is capable of penetrating dentinal tubules and surviving as a monoculture after conventional endodontic therapy, indicating that it is resistant to commonly used endodontic disinfection protocols. Different E. faecalis strains have shown resistance to several antibiotics, and have been associated with both dental pathology and systemic infections...
June 12, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28642751/in-vitro-antimicrobial-activity-of-chlorquinaldol-against-microorganisms-responsible-for-skin-and-soft-tissue-infections-comparative-evaluation-with-gentamicin-and-fusidic-acid
#12
Monica Bortolin, Alessandro Bidossi, Elena De Vecchi, Maura Avveniente, Lorenzo Drago
Skin and soft tissue infections (SSTIs) are a major therapeutic challenge for clinicians. The emergence of pathogens with decreased susceptibility to available therapies has become an emerging problem often associated with treatment failure. Hence, there is an urgent need for novel broad-spectrum antimicrobial agents. The purpose of this study was to assess the feasibility of chlorquinaldol as an alternative approach to currently used topical antibiotics for the treatment of skin and soft tissue infections...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28640870/dominance-of-community-associated-methicillin-resistant-staphylococcus-aureus-clones-in-a-maternity-hospital
#13
Edet E Udo, Noura Al-Sweih
BACKGROUND: Methicillin- resistant Staphylococcus aureus (MRSA) is a major pathogen causing healthcare- and community- acquired infections. The purpose of this study was to characterize MRSA isolated at the Maternity Hospital between 2006 and 2011 for their genetic relatedness. MATERIALS AND METHODS: The MRSA isolates were investigated using a combination of antibiogram, Staphylococcal chromosome cassette mec (SCCmec) and spa typing to determine their relatedness to MRSA isolated in other Kuwait hospitals...
2017: PloS One
https://www.readbyqxmd.com/read/28600216/molecular-epidemiology-and-antibiotic-resistance-of-methicillin-resistant-staphylococcus-aureus-circulating-in-the-russian-federation
#14
Vladimir Gostev, Alexander Kruglov, Olga Kalinogorskaya, Olga Dmitrenko, Olga Khokhlova, Tatsuo Yamamoto, Yuri Lobzin, Irina Ryabchenko, Sergey Sidorenko
The aim of this study was to investigate the patterns of antimicrobial resistance and molecular features of methicillin-resistant Staphylococcus aureus (MRSA) isolates in Russia. Isolates recovered from hospital patients (n=480), healthy medical personnel (n=25), and healthy carriers (n=13) were included in the study. Hospital-acquired MRSA (HA-MRSA) demonstrated high resistance to ciprofloxacin, gentamicin, and chloramphenicol (76%-92%), moderate - to tetracycline, erythromycin, clindamycin, and rifampicin (38%-54%), and low - to fusidic acid, co-trimoxazole, mupirocin, and daptomycin (2%-7%)...
June 7, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28592549/emergence-of-a-staphylococcus-aureus-clone-resistant-to-mupirocin-and-fusidic-acid-carrying-exotoxin-genes-and-causing-mainly-skin-infections
#15
Anastassios Doudoulakakis, Iris Spiliopoulou, Nikolaos Spyridis, Nikolaos Giormezis, John Kopsidas, Maria Militsopoulou, Evangelia Lebessi, Maria Tsolia
Skin and soft tissue infections (SSTIs) caused by mupirocin-resistant Staphylococcus aureus strains have recently increased in number in our settings. We sought to evaluate the characteristics of these cases over a 43-month period. Data for all community-acquired staphylococcal infections caused by mupirocin-resistant strains were retrospectively reviewed. Genes encoding products producing high-level resistance (HLR) to mupirocin (mupA), fusidic acid resistance (fusB), resistance to macrolides and lincosamides (ermC and ermA), Panton-Valentine leukocidin (PVL) (lukS/lukF-PV), exfoliative toxins (eta and etb), and fibronectin binding protein A (fnbA) were investigated by PCRs in 102 selected preserved strains...
August 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28592405/current-and-emerging-topical-antibacterials-and-antiseptics-agents-action-and-resistance-patterns
#16
REVIEW
Deborah A Williamson, Glen P Carter, Benjamin P Howden
Bacterial skin infections represent some of the most common infectious diseases globally. Prevention and treatment of skin infections can involve application of a topical antimicrobial, which may be an antibiotic (such as mupirocin or fusidic acid) or an antiseptic (such as chlorhexidine or alcohol). However, there is limited evidence to support the widespread prophylactic or therapeutic use of topical agents. Challenges involved in the use of topical antimicrobials include increasing rates of bacterial resistance, local hypersensitivity reactions (particularly to older agents, such as bacitracin), and concerns about the indiscriminate use of antiseptics potentially coselecting for antibiotic resistance...
July 2017: Clinical Microbiology Reviews
https://www.readbyqxmd.com/read/28542660/-trichomycosis-trichobacteriosis-capitis-in-an-infant-microbiological-dermoscopic-and-ultrastructural-features
#17
Alexandro Bonifaz, Ixchel Ramírez-Ricarte, Alejandra Rodríguez-Leviz, Marco A Hernández, Carlos Mena, Adriana Valencia
Trichomycosis is a superficial infection caused by Corynebacterium flavescens, which regularly affects axillary, and to a a lesser extent, pubic, scrotal and intergluteal, and exceptionally, head hairs or trichomycosis capitis (TC). This condition is characterised by the formation of bacterial nodules. Clinically, it can be confused with white piedra or pediculosis. The diagnosis is made by microscopic and dermoscopic observation and confirmed by culture. OBJECTIVE: To present a case of TC in an infant and illustrate the microscopic, dermoscopic, and ultrastructural characteristics...
April 2017: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/28533232/potentiation-of-antibiotic-activity-by-a-novel-cationic-peptide-potency-and-spectrum-of-activity-of-spr741
#18
David Corbett, Andrew Wise, Tara Langley, Kirsty Skinner, Emily Trimby, Stephen Birchall, Alain Dorali, Stephanie Sandiford, Jennifer Williams, Peter Warn, Martti Vaara, Troy Lister
Novel approaches for the treatment of multidrug-resistant Gram-negative bacterial infections are urgently required. One approach is to potentiate the efficacy of existing antibiotics whose spectrum of activity is limited by the permeability barrier presented by the Gram-negative outer membrane. Cationic peptides derived from polymyxin B have been used to permeabilize the outer membrane, granting antibiotics that would otherwise be excluded access to their targets. We assessed the in vitro efficacies of combinations of SPR741 with conventional antibiotics against Escherichia coli, Klebsiella pneumoniae, and Acinetobacter baumannii Of 35 antibiotics tested, the MICs of 8 of them were reduced 32- to 8,000-fold against E...
August 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28507488/microbiological-analysis-of-acute-infections-of-the-nail-fold-on-the-basis-of-bait-thread-test
#19
Hanna Tomczak, Aleksandra Dańczak-Pazdrowska, Adriana Polańska, Agnieszka Osmola-Mańkowska, Jakub Pazdrowski, Wioleta Błażejewska-Gąsior, Anna Horla, Marta Hasse-Cieślińska, Zygmunt Adamski
INTRODUCTION: An acute infection of the nail fold, called paronychia, is a common clinical problem. The basis for the implementation of the treatment is the result of microbiological examination. Due to the rapid and painful course of infection, usually an empirical antimicrobial treatment prior to obtaining microbiological test results is introduced. AIM: The microbial analysis of acute infections of the nail fold. MATERIAL AND METHODS: The study included 32 tests conducted on 31 patients of the Department of Dermatology...
April 2017: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/28435108/molecular-characterization-and-antimicrobial-susceptibility-of-the-ca-mrsa-isolated-from-healthcare-workers-tehran-iran
#20
Solmaz Ohadian Moghadam, Mohammad Modoodi Yaghooti, Nasrin Pourramezan, Mohammad Reza Pourmand
INTRODUCTION: Methicillin resistant Staphylococcus aureus (MRSA) has become as a nosocomial pathogen worldwide. Considering the importance of MRSA typing for understanding the evolution and dissemination of these strains, we studied the molecular characteristics of MRSA colonized healthcare workers (HCWs). METHODOLOGY: All MRSA isolated from HCWs, were genotyped using staphylococcal cassette chromosome mec (SCCmec) with multiplex PCR assay, multilocus sequence typing (MLST) and spa typing...
April 20, 2017: Microbial Pathogenesis
keyword
keyword
32829
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"