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Spinal cord ischemia

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https://www.readbyqxmd.com/read/28935349/spinal-ischemia-in-thoracic-aortic-procedures-impact-of-radiculomedullary-artery-distribution
#1
Fabian A Kari, Karin Wittmann, Sonja Krause, Babak Saravi, Luisa Puttfarcken, Katharina Förster, Bartosz Rylski, Sven Maier, Ulrich Göbel, Matthias Siepe, Martin Czerny, Friedhelm Beyersdorf
BACKGROUND: The aim of this study was to assess the influence of thoracic anterior radiculomedullary artery (tARMA) distribution on spinal cord perfusion in a thoracic aortic surgical model. METHODS: Twenty-six pigs (34 ± 3 kg; study group, n = 20; sham group, n = 6) underwent ligation of the left subclavian artery and thoracic segmental arteries. End points were spinal cord perfusion pressure (SCPP), regional spinal cord blood flow (SCBF), and neurologic outcome with an observation time of 3 hours...
September 18, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28921013/spinal-cord-injury-as-a-complication-of-thoracic-endovascular-aneurysm-repair
#2
REVIEW
Taijiro Sueda, Shinya Takahashi
OBJECTIVE: Spinal cord ischemia (SCI) is a devastating complication of thoracic aortic aneurysm repair in the era of thoracic endovascular aneurysm repair (TEVAR). This review aims to clarify the causes of SCI during TEVAR and to propose ways that it may be prevented. METHODS AND RESULTS: We performed an extensive literature search of SCI during TEVAR. Based on the existing literature, we examined the anatomy of the anterior spinal cord artery, which supplies blood to the anterior aspect of the spinal cord, and discuss reported effective ways to prevent SCI during TEVAR, including augmentation of arterial blood pressure and drainage of cerebrospinal fluid...
September 18, 2017: Surgery Today
https://www.readbyqxmd.com/read/28919363/thoracic-spinal-cord-and-cervical-vagosympathetic-neuromodulation-obtund-nodose-sensory-transduction-of-myocardial-ischemia
#3
Siamak Salavatian, Eric Beaumont, David Gibbons, Matthew Hammer, Donald B Hoover, J Andrew Armour, Jeffrey L Ardell
BACKGROUND: Autonomic regulation therapy involving either vagus nerve stimulation (VNS) or spinal cord stimulation (SCS) represents emerging bioelectronic therapies for heart disease. The objective of this study was to determine if VNS and/or SCS modulate primary cardiac afferent sensory transduction of the ischemic myocardium. METHODS: Using extracellular recordings in 19 anesthetized canines, of 88 neurons evaluated, 36 ventricular-related nodose ganglia sensory neurons were identified by their functional activity responses to epicardial touch, chemical activation of their sensory neurites (epicardial veratridine) and great vessel (descending aorta or inferior vena cava) occlusion...
August 18, 2017: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/28914869/-spinal-dural-arteriovenous-fistulas-a-series-of-clinical-cases-and-an-analysis-of-the-literature-data
#4
K N Babichev, V P Orlov, A V Stanishevskiy, A V Savello, D V Svistov
Spinal dural arteriovenous fistulas (SDAVFs) are the most common vascular malformation of the spinal cord, causing segmental lesions of the spinal cord due to venous ischemia. Functional outcomes of treatment in SDAVF patients are favorable, but the rate of improvement varies from 25 to 100%, which complicates prediction of the treatment outcome. AIM: the study aim was to identify a relationship between fistula localization and clinical manifestations and evaluate the effect of disease duration and severity of neurological impairments on immediate and long-term treatment outcomes, based on analysis of the literature and own data...
2017: Zhurnal Voprosy Neĭrokhirurgii Imeni N. N. Burdenko
https://www.readbyqxmd.com/read/28886701/the-loss-of-function-disease-mutation-g301r-in-the-na-k-atpase-%C3%AE-2-isoform-decreases-lesion-volume-and-improves-functional-outcome-after-acute-spinal-cord-injury-in-mice
#5
Ditte Gry Ellman, Toke Jost Isaksen, Minna Christiansen Lund, Safinaz Dursun, Martin Wirenfeldt, Louise Helskov Jørgensen, Karin Lykke-Hartmann, Kate Lykke Lambertsen
BACKGROUND: The Na(+)/K(+)-ATPases are transmembrane ion pumps important for maintenance of ion gradients across the plasma membrane that serve to support multiple cellular functions, such as membrane potentials, regulation of cellular volume and pH, and co-transport of signaling transmitters in all animal cells. The α2Na(+)/K(+)-ATPase subunit isoform is predominantly expressed in astrocytes, which us the sharp Na(+)-gradient maintained by the sodium pump necessary for astroglial metabolism...
September 8, 2017: BMC Neuroscience
https://www.readbyqxmd.com/read/28885295/morphometric-analysis-of-rat-spinal-cord-angioarchitecture-by-phase-contrast-radiography-from-2d-to-3d-visualization
#6
Tianding Wu, Yong Cao, Shuangfei Ni, Zixiang Luo, Liyuan Jiang, Hongbin Lu, Jianzhong Hu
STUDY DESIGN: An advanced imaging of vasculature with synchrotron radiation X-ray in a rat model. OBJECTIVE: To develop the potential for quantitative assessment of vessel network from 2D to 3D visualization by synchrotron radiation X-ray phase contrast tomography (XPCT) in rat spinal cord model. SUMMARY OF BACKGROUND DATA: Investigation of microvasculature contributes to the understanding of pathological development of spinal cord injury...
September 6, 2017: Spine
https://www.readbyqxmd.com/read/28881824/differential-gene-and-lncrna-expression-in-the-lower-thoracic-spinal-cord-following-ischemia-reperfusion-induced-acute-kidney-injury-in-rats
#7
Qing-Quan Liu, Hui Liu, Zhi-Gang He, Shi-Jie Zhang, Bao-Wen Liu, Le Wang, Wen-Hui Qiu, Qing Xu, Hong-Bing Xiang, Yong-Man Lv
We used high-throughput RNA sequencing to analyze differential gene and lncRNA expression patterns in the lower thoracic spinal cord during ischemia/reperfusion (I/R)-induced acute kidney injury (AKI) in rats. We observed that of 32662 mRNAs, 4296 out were differentially expressed in the T8-12 segments of the spinal cord upon I/R-induced AKI. Among these, 62 were upregulated and 34 were downregulated in response to I/R (FDR < 0.05, |log2FC| > 1). Further, 52 differentially expressed lncRNAs (35 upregulated and 17 downregulated) were identified among 3849 lncRNA transcripts...
August 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28880879/lotus-overexpression-accelerates-neuronal-plasticity-after-focal-brain-ischemia-in-mice
#8
Hajime Takase, Yuji Kurihara, Taka-Akira Yokoyama, Nobutaka Kawahara, Kohtaro Takei
Nogo receptor-1 (NgR1) and its ligands inhibit neuronal plasticity and limit functional recovery after brain damage such as ischemic stroke. We have previously shown that lateral olfactory tract usher substance (LOTUS) antagonizes NgR1-mediated signaling. Here, we investigated whether LOTUS enhances neuronal plasticity and functional recovery after brain focal ischemia in adult mice. Focal ischemic infarcts were induced in wild-type and LOTUS-overexpressing transgenic mice via middle cerebral artery occlusion...
2017: PloS One
https://www.readbyqxmd.com/read/28874089/outcome-of-surgeon-modified-fenestrated-branched-stent-grafts-for-symptomatic-complex-aortic-pathologies-or-contained-rupture
#9
Nikolaos Tsilimparis, Franziska Heidemann, Fiona Rohlffs, Holger Diener, Sabine Wipper, E Sebastian Debus, Tilo Kölbel
PURPOSE: To analyze the outcome of surgeon-modified fenestrated and branched stent-grafts (sm-FBSG) in high-risk patients with symptomatic complex aortic pathology or contained rupture. METHODS: A single-center retrospective analysis was conducted of 21 consecutive patients (mean age 70 years, range 58-87; 16 men) treated with a sm-FBSG from April 2014 to September 2016. The indications included 11 thoracoabdominal and 10 pararenal aortic pathologies, which presented as symptomatic in 8 and as contained rupture in 13 patients...
September 1, 2017: Journal of Endovascular Therapy
https://www.readbyqxmd.com/read/28852401/aldehyde-dehydrogenase-2-overexpression-inhibits-neuronal-apoptosis-after-spinal-cord-ischemia-reperfusion-injury
#10
Xing-Zhen Liu, Xin Sun, Kang-Ping Shen, Wen-Jie Jin, Zhi-Yi Fu, Hai-Rong Tao, Zhi-Xing Xu
Aldehyde dehydrogenase 2 (ALDH2) is an important factor in inhibiting oxidative stress and has been shown to protect against renal ischemia/reperfusion injury. Therefore, we hypothesized that ALDH2 could reduce spinal cord ischemia/reperfusion injury. Spinal cord ischemia/reperfusion injury was induced in rats using the modified Zivin's method of clamping the abdominal aorta. After successful model establishment, the agonist group was administered a daily consumption of 2.5% alcohol. At 7 days post-surgery, the Basso, Beattie, and Bresnahan score significantly increased in the agonist group compared with the spinal cord ischemia/reperfusion injury group...
July 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28844181/changes-in-pressure-hemodynamics-and-metabolism-within-the-spinal-cord-during-the-first-7-days-after-injury-using-a-porcine-model
#11
Femke Streijger, Kitty So, Neda Manouchehri, Jae H T Lee, Elena B Okon, Katelyn Shortt, So-Eun Kim, Kurt McInnes, Peter Cripton, Brian K Kwon
Traumatic spinal cord injury (SCI) triggers many perturbations within the injured cord, such as decreased perfusion, reduced tissue oxygenation, increased hydrostatic pressure, and disrupted bioenergetics. While much attention is directed to neuroprotective interventions that might alleviate these early pathophysiologic responses to traumatic injury, the temporo-spatial characteristics of these responses within the injured cord are not well documented. In this study, we utilized our Yucatan mini-pig model of traumatic SCI to characterize intraparenchymal hemodynamic and metabolic changes within the spinal cord for 1 week post-injury...
September 14, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28828029/oral-administration-of-red-ginseng-extract-promotes-neurorestoration-after-compressive-spinal-cord-injury-in-rats
#12
Pengxiang Zhu, Keiichi Samukawa, Hiroko Fujita, Hidemasa Kato, Masahiro Sakanaka
Red ginseng and its active ingredients have been shown to decrease neuron death after brain ischemia in experimental animals. However, little is known about the effects of orally administered ginseng extract on spinal cord injury. We orally gave red ginseng extract (RGE) to rats with compressed spinal cord injury (SCI). Open-field locomotor scores were measured as indices of motor function. Histopathological changes and cytokine expressions in situ after SCI were evaluated. Compared to vehicle treatment, RGE treatment (350 mg/kg/day) significantly improved locomotor score up to levels close to those pre-SCI, prevented neuron loss, and facilitated the restoration of white matter in the spinal cord at 14 days after SCI...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28820864/diffusion-kurtosis-imaging-and-pathology-in-spinal-cord-ischemia-reperfusion-injury-in-rabbits-a-case-control-study
#13
Daowei Li, Xiaoming Wang
BACKGROUND The aim of this study was to evaluate the application of diffusion kurtosis imaging (DKI) in spinal cord ischemia/reperfusion (SCI/R) injury and to explore its association with pathology. MATERIAL AND METHODS Japanese male long-eared rabbits were chosen and divided into 7 groups (8 rabbits in each group): control group (C group), sham-operation control group (S group), and 5 experimental groups (E-2 h group, E-24 h group, E-48 h group, E-7 d group, and E-14 d group). Tarlov scoring and immunohistochemical staining were used to assess hindlimb motor function and observe the expression of glial fiber acidic protein (GFAP), respectively...
August 18, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28820047/reversal-of-spinal-cord-ischemia-following-endovascular-thoracic-aortic-aneurysm-repair-with-hyperbaric-oxygen-and-therapeutic-hypothermia
#14
Emmanuel Urquieta, Joseph Varon, Peter H Lin
BACKGROUND: Neurological adverse events with spinal cord ischemia (SCI) remain one of the most feared complications in patients undergoing thoracic endovascular aortic repair (TEVAR). These patients can develop irreversible paraplegia with lifelong consequences with physical and psychological agony. CASE PRESENTATION: We herein present a patient who developed SCI with bilateral lower leg paraplegia on the third postoperative day following TEVAR. Spinal catheter was inserted for spinal fluid drainage...
January 1, 2017: Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28818295/total-endovascular-treatment-for-extent-type-1-and-5-thoracoabdominal-aortic-aneurysms
#15
Gabriele Piffaretti, Federico Fontana, Marco Franchin, Alessandro Bacuzzi, Walter Dorigo, Patrizio Castelli, Matteo Tozzi
OBJECTIVE: The study objective was to describe the results of thoracic endovascular aortic repair with the intentional coverage of the celiac artery and distal supramesenteric landing zone for extent type 1 and type 5 thoracoabdominal aortic aneurysms. METHODS: Inclusion criteria were thoracic endovascular aortic repair with celiac artery coverage to treat elective or urgent extent type 1 and 5 thoracoabdominal aortic aneurysms. Primary end points were in-hospital and follow-up survival, freedom from aortic-related mortality, and freedom from reintervention...
July 22, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28804557/motor-neuron-degeneration-following-glycine-mediated-excitotoxicity-induces-spastic-paralysis-after-spinal-cord-ischemia-reperfusion-injury-in-rabbit
#16
Li Wang, Sen Li, Yuan Liu, Dong-Liang Feng, Long Jiang, Zai-Yun Long, Ya-Min Wu
Spinal cord ischemia and reperfusion (SCIR) injury is the major cause of a wide range of complications, including neural degeneration and devastating paraplegia. Decrease of inhibitory neurotransmitters and increase of excitory neurotransmitters are the major cause for the excitotoxicity of neurons. However, no study has reported the temporal loss of motor neuron in the ventral horn of spinal cord area following SCIR-induced spastic paralysis, not even the mechanism under it. In the present study, we found that the rabbits were mainly spastic paralyzed after spinal cord ischemia-reperfusion injury...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28756047/effectiveness-of-surgical-interventions-for-thoracic-aortic-aneurysms-a-systematic-review-and-meta-analysis
#17
REVIEW
Mouaz Alsawas, Feras Zaiem, Laura Larrea-Mantilla, Jehad Almasri, Patricia J Erwin, Gilbert R Upchurch, M Hassan Murad
OBJECTIVE: A systematic review and meta-analysis was conducted to evaluate the effectiveness of thoracic endovascular aortic repair (TEVAR) and open repair in patients with descending thoracic aortic aneurysms (TAAs). METHODS: PubMed, Ovid MEDLINE, Ovid Embase, EBSCO Cumulative Index to Nursing and Allied Health Literature, and Scopus were searched from each database's inception to January 29, 2016. We selected studies that compared the two approaches in adults with TAAs and reported 30-day mortality or procedure complications...
July 26, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28754163/choroid-plexus-cerebrospinal-fluid-route-for-monocyte-derived-macrophages-after-stroke
#18
Ruimin Ge, Daniel Tornero, Masao Hirota, Emanuela Monni, Cecilia Laterza, Olle Lindvall, Zaal Kokaia
BACKGROUND: Choroid plexus (CP) supports the entry of monocyte-derived macrophages (MDMs) to the central nervous system in animal models of traumatic brain injury, spinal cord injury, and Alzheimer's disease. Whether the CP is involved in the recruitment of MDMs to the injured brain after ischemic stroke is unknown. METHODS: Adult male C57BL/6 mice were subjected to focal cortical ischemia by permanent occlusion of the distal branch of the right middle cerebral artery...
July 28, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28753453/mir-136-controls-neurocytes-apoptosis-by-regulating-tissue-inhibitor-of-metalloproteinases-3-in-spinal-cord-ischemic-injury
#19
Rilong Jin, Sanzhong Xu, Xiangjin Lin, Miaoda Shen
BACKGROUND: Spinal cord ischemia is a serious injury that threatens human health and life. Furthermore, it was widely accepted that miR-136 was mediated in the spinal injury, while whether it regulated neurocytes apoptosis in I/R-induced spinal cord injury remains unclear. METHODS: Spinal cord ischemia injury (SCII) rats were induced by clamping the nontraumatic vascular clip on the abdominal aorta. Real-time PCR was conducted to determine the mRNA expression, and western blot was carried out to measure protein expression...
October 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28745670/-the-administration-of-neurocytoprotectors-in-a-rat-model-of-experimental-spinal-cord-ischemia
#20
G V Ponomarev, A A Shmonin, A G Shumeeva, K T Aliev, T D Vlasov, A A Skoromets
AIM: To study an effect of cortexin on functional recovery and morphology of the spinal cord of rats with spinal cord ischemia. MATERIAL AND METHODS: Spinal cord ischemia was achieved by ligation of the infrarenal abdominal aorta in 16 rats stratified into two equal groups: the ligation of infrarenal aorta was performed in the control group, aorta ligation was performed also in the experimental group with preliminary intraperitoneally administration of cortexin in a dose of 0...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
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