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https://www.readbyqxmd.com/read/29050222/beneficial-effect-of-fluoxetine-treatment-aganist-psychological-stress-is-mediated-by-increasing-bdnf-expression-in-selected-brain-areas
#1
Gongying Li, Ping Jing, Zhidong Liu, Zhiruo Li, Hongxia Ma, Wenzhen Tu, Wei Zhang, Chuanjun Zhuo
SSRI antidepressant fluoxetine is widely used to treat psychological stress related disorders, however the underlying working mechanisms is not fully understood, as SSRIs can rapidly increase the extracellular serotonin levels but it normally takes weeks to reveal their therapeutic effect in the stress-related psychological disorders. Our previous study demonstrated that purely psychological stress without any physic stimuli induces a biphasic change in the expression of brain-derived neurotrophic factor (BDNF), which immediately decrease and then gradually increase after the stress; and that the latter BDNF increase in response to the psychological stress involves the activation of serotonin system...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050216/high-number-of-chromosomal-copy-number-aberrations-inversely-relates-to-t-11-19-q21-p13-translocation-status-in-mucoepidermoid-carcinoma-of-the-salivary-glands
#2
Johannes H Matse, Enno C I Veerman, Jan G M Bolscher, C René Leemans, Bauke Ylstra, Elisabeth Bloemena
Although rare, mucoepidermoid carcinoma (MEC) is one of the most common malignant salivary gland tumors. The presence of the t(11;19)(q21;p13) translocation in a subset of MECs has raised interest in genomic aberrations in MEC. In the present study we conducted genome-wide copy-number-aberration analysis by micro-array comparative-genomic-hybridization on 27 MEC samples. Low/intermediate-grade MECs had significantly fewer copy-number-aberrations compared to high-grade MECs (low vs high: 3.48 vs 30; p = 0.0025; intermediate vs high: 5...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050151/-relationship-between-helicobacter-pylori-infection-and-mir-24-3p-expression-during-the-development-of-gastric-mucosa-lesions
#3
C Li, Y L Zhu, Q Li, D S Li, G B Yang
Objectives: To explore the expression of micro RNA-24-3p (miR-24-3p) in different gastric mucosa lesions, and analyze the potential correlation between Helicobacter pylori (H.pylori) infection and miR-24-3p expression in different gastric lesions. Methods: 158 gastric biopsy specimens were divided into four groups, including 35 chronic superficial gastritis (CSG) samples, 43 chronic atrophic gastritis (CAG) samples, 41 intestinal metaplasia (IM) samples and 39 dysplasia (Dys) samples. Those samples were collected from patients undergoing gastroscopy at the Department of Gastroenterology, Aerospace Center Hospital, from September 2005 to June 2012...
September 26, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29050074/-clinicopathologic-characteristics-and-prognosis-of-neoplastic-cell-rich-mixed-cellularity-classic-hodgkin-lymphoma
#4
W H Hou, P Wei, J L Xie, Y Y Zheng, X G Zhou
Objective: To investigate the clinicopathologic characteristics of neoplastic cell-rich mixed cellularity classical Hodgkin lymphoma(MCCHL-R) and to compare the prognosis with typical mixed cellularity classic Hodgkin lymphoma(MCCHL). Methods: Fifty-four patients with MCCHL-R(the tumor cells >10%) and 65 patients with typical MCCHL identified from 1 721 Hodgkin lymphomas were reviewed to compare the clinicopathological characteristics including morphologic and immunophenotypic features, EBV infection status, clinical therapy and overall survival...
October 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29050068/-diagnostic-and-prognostic-roles-of-loss-of-cic-protein-expression-in-oligodendroglial-tumors
#5
C C Liu, L Y Zhang, L M Wang, D D Wang, Y J Fu, Y N Cai, D H Lu, Y S Piao
Objective: To investigate the usefulness of loss of CIC expression as the prescreening detection of 1p/19q co-deletion in the diagnosis of oligodendroglial tumors and its prognostic implication. Methods: The retrospective study included 113 oligodendroglial tumors diagnosed in the Department of Pathology, Xuanwu Hospital, Capital Medical University. Expression of CIC protein was detected by immunohistochemistry, and the 1p/19q co-deletion by fluorescence in situ hybridization in all the tumors; and the correlation of the loss of protein and 1p/19q co-deletion with prognosis was assessed...
October 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29049972/noble-metals-decorated-hierarchical-maghemite-magnetic-tubes-as-an-efficient-recyclable-catalyst
#6
Rahul Purbia, Santanu Paria
The noble metal nanocatalysts on high surface area magnetic material supports have huge technological importance in the field of catalysis. The green synthesis of magnetic-noble metal hybrid material has another technological importance. In this study, we report a novel, efficient, and sustainable synthesis methodology for Au nanoparticles (NPs) deposited hierarchical magnetic maghemite (γ-Fe2O3) tubes. In this methodology, the green tea extract was used as a reducing agent for both iron oxide and Au NPs synthesis...
October 7, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29049947/3d-spongy-graphene-modified-screen-printed-sensors-for-the-voltammetric-determination-of-the-narcotic-drug-codeine
#7
Mona A Mohamed, Dalia M El-Gendy, Nashaat Ahmed, Craig E Banks, Nageh K Allam
Adenine-functionalized spongy graphene (FSG) composite, fabricated via a facile and green synthetic method, has been explored as a potential electrocatalyst toward the electroanalytical sensing of codeine phosphate (COD). The synthesized composite is characterized using Fourier transform infrared spectroscopy (FTIR), Raman spectroscopy, X-ray powder diffraction, UV-vis absorption spectroscopy, scanning electron microscopy, high resolution transmission electron microscopy (HRTEM), and thermogravimetric analysis...
October 11, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29049878/unifying-exchange-sensitivity-in-transition-metal-spin-state-ordering-and-catalysis-through-bond-valence-metrics
#8
Terry Z H Gani, Heather J Kulik
Accurate predictions of spin-state ordering, reaction energetics and barrier heights are critical for the computational discovery of open-shell transition metal (TM) catalysts. Semilocal approximations in density functional theory, such as the generalized gradient approximation (GGA), suffer from delocalization error that causes them to overstabilize strongly bonded states. Descriptions of energetics and bonding are often improved by introducing a fraction of exact exchange (e.g., erroneous low-spin GGA ground states instead correctly predicted as high-spin with a hybrid functional)...
October 19, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29049874/balancing-bacteria-osteoblasts-competition-through-selective-physical-puncture-and-biofunctionalization-of-zno-polydopamine-arginine-glycine-aspartic-acid-cysteine-nanorods
#9
Jun Li, Lei Tan, Xiangmei Liu, Zhenduo Cui, Xianjin Yang, Kelvin Wai Kwok Yeung, Paul K Chu, Shuilin Wu
Bacterial infection and lack of bone tissue integration are two major concerns of orthopedic implants. In addition, osteoinductivity often decreases and toxicity may arise when antibacterial agents are introduced to increase the antibacterial ability. Here hybrid ZnO/polydopamine (PDA)/arginine-glycine-aspartic acid-cysteine (RGDC) nanorod (NR) arrays are designed and prepared on titanium (Ti) implants to not only enhance the osteoinductivity but also effectively kill bacteria simultaneously, which are ascribed to the selective physical puncture and the biofunctionalization of ZnO/PDA/RGDC nanorods during the competition between bacteria and osteoblasts, that is, owing to the much larger size of osteoblasts than bacteria, the hybrid NRs can puncture bacteria but not damage osteoblasts...
October 19, 2017: ACS Nano
https://www.readbyqxmd.com/read/29049729/myocilin-regulates-metalloprotease-2-activity-through-interaction-with-timp3
#10
Myung Kuk Joe, Raquel L Lieberman, Naoki Nakaya, Stanislav I Tomarev
Purpose: To elucidate functions of wild-type myocilin, a secreted glycoprotein associated with glaucoma. Methods: Lysates of mouse eyes were used for immunoprecipitation with affinity-purified antibodies against mouse myocilin. Shotgun proteomic analysis was used for the identification of proteins interacting with myocilin. Colocalization of myocilin and tissue inhibitor of metalloproteinases 3 (TIMP3) in different eye structures was investigated by a multiplex fluorescent in situ hybridization and immunofluorescent labeling with subsequent confocal microscopy...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29049711/hybrid-treatment-combining-robotic-coronary-artery-bypass-grafting-and-percutaneous-catheter-radiofrequency-ablation
#11
Tatsuya Tarui, Norihiko Ishikawa, Ryuta Kiuchi, Go Watanabe
Isolated coronary artery bypass grafting associated with atrial fibrillation is routinely performed through a sternotomy, and cardiac arrest. Advancements in this surgical approach have led to better cosmesis, a quick postoperative recovery, with the same postoperative results. We report a case of a novel, less invasive hybrid treatment combining robot-assisted coronary artery bypass grafting and percutaneous radiofrequency catheter ablation.
August 31, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29049708/two-staged-hybrid-ablation-of-non-paroxysmal-atrial-fibrillation-clinical-outcomes-and-functional-improvements-after-1%C3%A2-year
#12
Petr Budera, Pavel Osmancik, David Talavera, Anna Kraupnerova, Richard Fojt, Jana Zdarska, Tomas Vanek, Zbynek Straka
OBJECTIVES: Hybrid ablation of atrial fibrillation (AF) is a promising treatment strategy; however, data regarding its efficacy and safety are still limited. METHODS: Patients with non-paroxysmal AF were enrolled. First, a thoracoscopic, epicardial isolation of pulmonary veins and the left atrial posterior wall ('box lesion') was performed; a novel unipolar/bipolar radiofrequency device was used. Moreover, in 12 patients enrolled thereafter, the left atrial appendage was occluded...
July 31, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29049664/acute-type-i-aortic-dissection-a-propensity-matched-comparison-of-elephant-trunk-and-arch-debranching-repairs
#13
Mingjia Ma, Xin Feng, Jing Wang, Yiming Dong, Taiqiang Chen, Ligang Liu, Xiang Wei
OBJECTIVES: Our goal was to compare the performance of the frozen elephant trunk (FET) and the hybrid aortic arch debranching procedures for acute Type I aortic dissection. METHODS: From January 2013 to December 2015, 168 patients with Type I aortic disease underwent ascending aorta and total aortic arch replacement with FET implantation (the FET group, n  = 132) or arch debranching with 1-stage aortic arch exclusion using an endovascular stent in a retrograde manner (the debranching group, n  = 36)...
September 11, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29049613/hybrid-operating-room-dyna-computed-tomography-combined-image-guided-electromagnetic-navigation-bronchoscopy-dye-marking-and-hookwire-localization-video-assisted-thoracic-surgery-metastasectomy
#14
Calvin S H Ng, Cheuk Man Chu, Cheuk Kin Lo, Rainbow W H Lau
Hybrid operating room Dyna-computed tomography imaging is increasingly recognized as an important adjunct for management of small pulmonary lesions, either for biopsy or for localization to guide surgical resection. We describe for the first time the combined hybrid operating room Dyna-computed tomography image-guided electromagnetic navigation bronchoscopy dye marking and hookwire localization approach to localize multiple sub-centimetre nodules for video-assisted thoracic surgery metastasectomy. Furthermore, such complex set of procedures can be safely and effectively performed within one operating environment, maximizing work efficiency and minimizing the potential for complications...
September 27, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29049523/oral-human-papillomavirus-infection-differences-in-prevalence-between-sexes-and-concordance-with-genital-human-papillomavirus-infection-nhanes-2011-to-2014
#15
Kalyani Sonawane, Ryan Suk, Elizabeth Y Chiao, Jagpreet Chhatwal, Peihua Qiu, Timothy Wilkin, Alan G Nyitray, Andrew G Sikora, Ashish A Deshmukh
Background: The burden of human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) is disproportionately high among men, yet empirical evidence regarding the difference in prevalence of oral HPV infection between men and women is limited. Concordance of oral and genital HPV infection among men is unknown. Objective: To determine the prevalence of oral HPV infection, as well as the concordance of oral and genital HPV infection, among U.S...
October 17, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29049400/spoligotyping-and-whole-genome-sequencing-analysis-of-lineage-1-strains-of-mycobacterium-tuberculosis-in-da-nang-vietnam
#16
Minako Hijikata, Naoto Keicho, Le Van Duc, Shinji Maeda, Nguyen Thi Le Hang, Ikumi Matsushita, Seiya Kato
BACKGROUND: Spacer oligonucleotide typing (spoligotyping), a widely used, classical genotyping method for Mycobacterium tuberculosis complex (MTBC), is a PCR-based dot-blot hybridization technique to detect the genetic diversity of the direct repeat (DR) region. Of the seven major MTBC lineages in the world, lineage 1 (Indo-Oceanic) mostly corresponds to the East African-Indian (EAI) spoligotype family in East Africa and Southeast Asia. OBJECTIVES: We investigated the genomic features of Vietnamese lineage 1 strains, comparing spoligotype patterns using whole-genome sequencing (WGS) data...
2017: PloS One
https://www.readbyqxmd.com/read/29048940/a-cpgcluster-teaching-learning-based-optimization-for-prediction-of-cpg-islands-in-the-human-genome
#17
Cheng-Hong Yang, Yi-Cheng Chiang, Li-Yeh Chuang, Yu-Da Lin
Many CpG island detection methods have been proposed based on sliding window and clustering technology, but the accuracy of these methods is proportional to the time required. Therefore, an accurate and rapid method for identifying CpG islands remains an important challenge in the complete human genome. We propose a hybrid method CpGTLBO to detect the CpG islands in the human genome. The method uses the clustering approach and the teaching-learning-based optimization (TLBO) algorithm. The clustering approach is used to detect CpG island candidates, and it can effectively reduce the huge volume of unnecessary DNA fragments...
October 19, 2017: Journal of Computational Biology: a Journal of Computational Molecular Cell Biology
https://www.readbyqxmd.com/read/29048904/ultra-high-elastic-strain-energy-storage-in-metal-oxide-infiltrated-patterned-hybrid-polymer-nanocomposites
#18
Keith Dusoe, Xinyi Ye, Kim Kisslinger, Aaron Stein, Seok-Woo Lee, Chang-Yong Nam
Modulus of resilience, the measure of a material's ability to store and release elastic strain energy, is critical for realizing advanced mechanical actuation technologies in micro/nanoelectromechanical systems. In general, engineering the modulus of resilience is difficult because it requires asymmetrically increasing yield strength and Young's modulus against their mutual scaling behavior. This task becomes further challenging if it needs to be carried out at the nanometer scale. Here, we demonstrate organic-inorganic hybrid composite nanopillars with one of the highest modulus of resilience per density, by utilizing vapor-phase aluminum oxide infiltration in lithographically patterned negative photoresist SU-8...
October 19, 2017: Nano Letters
https://www.readbyqxmd.com/read/29048749/the-inheritance-of-mitochondrial-dna-in-interspecific-saccharomyces-hybrids-and-their-properties-in-winemaking
#19
Alexandra Verspohl, Samuele Pignedoli, Paolo Giudici
The inheritance of mitochondrial DNA (mtDNA) in yeast hybrids is heteroplasmic, turing into homoplasmic after few cell cycles. Mitotype restoration is reported to be biparental and random. This study shows that mitotype restoration follows fixed schemata. We created isogenic, interspecific Saccharomyces cerevisiae x Saccharomyces uvarum hybrids through direct mating and analysed their mating frequency and mitotype. The mating frequency increased for most crosses in staggered mating. Mitotyping revealed that breeding lines with the same parental strain of S...
October 19, 2017: Yeast
https://www.readbyqxmd.com/read/29048720/controllable-modular-growth-of-hierarchical-mof-on-mof-architectures
#20
Yifan Gu, Yi-Nan Wu, Liangchun Li, Wei Chen, Fengting Li, Susumu Kitagawa
Fabrication of hybrid MOF-on-MOF heteroarchitectures can create novel and multifunctional platforms to achieve desired properties. However, only MOFs with similar crystallographic parameters can be hybridized by the classical epitaxial growth method (EGM), which largely suppressed its applications. Herein, we demonstrated a general strategy called internal extended growth method (IEGM) for the feasible assembly of MOFs with distinct crystallographic parameters in an MOF matrix. Various MOFs with diverse functions could be introduced in a modular MOF matrix to form 3D core-satellite pluralistic hybrid system...
October 19, 2017: Angewandte Chemie
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