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https://www.readbyqxmd.com/read/29471523/liver-transcriptomic-and-plasma-metabolomic-profiles-of-fattening-lambs-are-modified-by-feed-restriction-during-the-suckling-period
#1
A Santos, F J Giráldez, E Trevisi, L Lucini, J Frutos, S Andrés
The increasing world population is driving demand for improved efficiency of feed resources of livestock. However, the molecular mechanisms behind various feed efficiency traits and their regulation by nutrition remain poorly understood. Here we aimed to identify differentially expressed (DE) genes in the liver tissues of fattening Merino lambs and differences in metabolites accumulated in plasma to identify modified metabolic pathways as a consequence of milk restriction during the suckling period. Twenty-four male Merino lambs (4...
February 19, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29471487/the-lesser-antillean-iguana-iguana-delicatissima-on-st-eustatius-genetically-depauperate-and-threatened-by-ongoing-hybridization
#2
Matthijs P van den Burg, Patrick G Meirmans, Tim van Wagensveld, Bart Kluskens, Hannah Madden, Mark E Welch, Johannes A J Breeuwer
The Lesser Antillean Iguana (Iguana delicatissima) is an endangered species threatened by habitat loss and hybridization with non-native Green Iguanas (Iguana iguana). Iguanadelicatissima has been extirpated on several islands, and the Green Iguana has invaded most islands with extant populations. Information is essential to protect this species from extinction. We collected data on 293 iguanas including 17 juveniles from St. Eustasius, one of the few remaining I. delicatissima strongholds. Genetic data was leveraged to test for hybridization presence with the Green Iguana using both mitochondrial and nuclear genes, including 16 microsatellite loci...
February 19, 2018: Journal of Heredity
https://www.readbyqxmd.com/read/29471395/origin-and-composition-of-cell-free-dna-in-spent-medium-from-human-embryo-culture-during-preimplantation-development
#3
M Vera-Rodriguez, A Diez-Juan, J Jimenez-Almazan, S Martinez, R Navarro, V Peinado, A Mercader, M Meseguer, D Blesa, I Moreno, D Valbuena, C Rubio, C Simon
STUDY QUESTION: What is the origin and composition of cell-free DNA in human embryo spent culture media? SUMMARY ANSWER: Cell-free DNA from human embryo spent culture media represents a mix of maternal and embryonic DNA, and the mixture can be more complex for mosaic embryos. WHAT IS KNOWN ALREADY: In 2016, ~300 000 human embryos were chromosomally and/or genetically analyzed using preimplantation genetic testing for aneuploidies (PGT-A) or monogenic disorders (PGT-M) before transfer into the uterus...
February 20, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29471390/hybrid-treatment-for-a-type-2-kommerell-s-aneurysm-in-a-nonagenarian
#4
Vasileios D Tzilalis, Ioannis G Kantounakis, Konstantinos M Pirgakis, Antonios Ch Chalkias
No abstract text is available yet for this article.
February 19, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29471294/novel-familial-variant-of-the-desert-hedgehog-gene-clinical-findings-in-two-sisters-with-46-xy-gonadal-dysgenesis-or-46-xx-karyotype-and-literature-review
#5
Fulvia Baldinotti, Tiziana Cavallaro, Eleonora Dati, Giampiero I Baroncelli, Veronica Bertini, Angelo Valetto, Francesco Massart, Gian Maria Fabrizi, Giampietro Zanette, Diego Peroni, Silvano Bertelloni
BACKGROUND: In humans, Desert Hedgehog (DHH) gene mutations are a very rare cause of 46,XY gonadal dysgenesis (GD), eventually associated with peripheral neuropathy. PATIENTS AND METHODS: Clinical records of 12 patients with 46,XY GD and unknown genetic background were reviewed and a 46,XY woman with peripheral neuropathy was individuated. Her 46,XX sister affected by similar neuropathy was also investigated. Genomic DNA was extracted and DHH exons sequenced and analyzed...
February 22, 2018: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/29471203/significance-of-an-in-situ-generated-boundary-film-on-tribocorrosion-behavior-of-polymer-metal-sliding-pair
#6
Yongkun Xu, Huimin Qi, Guitao Li, Xueping Guo, Yong Wan, Ga Zhang
Polymer composites have a high potential for applications as tribo-materials exposed to sea water owing to their self-lubrication characteristic and high chemical stability. In the present work, tribological behaviors of polyetheretherketone (PEEK) composites rubbing with stainless steel in sea water were explored using a pin-on-disc tribometer integrated with a potentiostat for electrochemical control. It was demonstrated that further adding 5 vol% hexagonal boron nitride (h-BN) nanoparticles into PEEK reinforced with short carbon fibers (SCF) significantly enhanced the wear resistance...
February 13, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29471144/intestinal-absorption-and-activation-of-decitabine-amino-acid-ester-prodrugs-mediated-by-peptide-transporter-pept1-and-enterocyte-enzymes
#7
Wenhui Tao, Dongyang Zhao, Mengchi Sun, Ziyu Wang, Bin Lin, Yu Bao, Yingying Li, Zhonggui He, Yinghua Sun, Jin Sun
Decitabine (DAC), a potent DNA methyltransferase (DNMT) inhibitor, has a limited oral bioavailability. Its 5'-amino acid ester prodrugs could improve its oral delivery but the specific absorption mechanism is not yet fully understood. The aim of this present study was to investigate the in vivo absorption and activation mechanism of these prodrugs using in situ intestinal perfusion and pharmacokinetics studies in rats. Although PEPT1 transporter is pH dependent, there appeared to be no proton cotransport in the perfusion experiment with a preferable transport at pH 7...
February 19, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29471114/reference-size-matching-whole-genome-amplification-and-fluorescent-labeling-as-a-method-for-chromosomal-microarray-analysis-of-clinically-actionable-copy-number-alterations-in-formalin-fixed-paraffin-embedded-tumor-tissue
#8
Shelly R Gunn, Shailin Govender, Cynthe L Sims, Aditi Khurana, Samuel Koo, Jayne Scoggin, Mathew W Moore, Philip D Cotter
Cancer genome copy number alterations (CNAs) assist clinicians in selecting targeted therapeutics. Solid tumor CNAs are most commonly evaluated in formalin-fixed, paraffin-embedded (FFPE) tissue by fluorescence in situ hybridization. Although fluorescence in situ hybridization is a sensitive and specific assay for interrogating pre-selected genomic regions, it provides no information about co-existing clinically significant copy number changes. Chromosomal microarray analysis is an alternative DNA-based method for interrogating genome-wide CNAs in solid tumors...
February 19, 2018: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/29471050/the-protein-protein-interactions-between-amsacta-moorei-entomopoxvirus-amev-protein-kinases-pks-and-all-viral-proteins
#9
Mehtap Danismazoglu, Remziye Nalcacioglu, Hacer Muratoglu, Zihni Demirbag
Entomopoxviruses are an important group of viruses infecting only insects. They belong to Poxviridae which infect both invertebrates and vertebrates, including humans. Protein kinases are known to have roles at virus morphogenesis, host selectivity, the regulation of cell division and apoptosis in some vertebrate poxviruses. In this study, 2 protein kinases (PKs) (AMV153 and AMV197) of Amsacta moorei entomopoxvirus (AMEV) were investigated for the interactions among 230 viral proteins using yeast two-hybrid system (Y2H)...
February 19, 2018: Virus Research
https://www.readbyqxmd.com/read/29471010/phylogenetic-diversity-and-biodiversity-indices-on-phylogenetic-networks
#10
Kristina Wicke, Mareike Fischer
In biodiversity conservation it is often necessary to prioritize the species to conserve. Existing approaches to prioritization, e.g. the Fair Proportion Index and the Shapley Value, are based on phylogenetic trees and rank species according to their contribution to overall phylogenetic diversity. However, in many cases evolution is not treelike and thus, phylogenetic networks have been developed as a generalization of phylogenetic trees, allowing for the representation of non-treelike evolutionary events, such as hybridization...
February 19, 2018: Mathematical Biosciences
https://www.readbyqxmd.com/read/29470932/precise-identification-of-wheat-i-thinopyrum-intermedium-i-translocation-chromosomes-carrying-resistance-to-wheat-stripe-rust-in-line-z4-and-its-derived-progenies
#11
Tao Lang, Shixiao La, Bin Li, Zhihui Yu, Qiheng Chen, Jianbo Li, Ennian Yang, Guangrong Li, Zujun Yang
2 The wheat- Thinopyrum intermedium derived line Z4 has displayed novel and effective stripe rust resistance for over 40 years. This study aimed to precisely identify the chromosome constitution of Z4 and determine the stripe rust resistance contribution using multicolor fluorescent in situ hybridization (FISH) and molecular marker analysis. The results indicated that the Z4 line (2n=44) contained two pairs of non-Robertsonian translocations without the 3A chromosomes of wheat. FISH karyotypes of F3 progenies derived from crosses between Z4 and MY11 indicated that the transmission of the translocated chromosomes appeared normal and the number of wheat chromosomes 3A and 3D frequently varied...
February 22, 2018: Genome Génome / Conseil National de Recherches Canada
https://www.readbyqxmd.com/read/29470849/direct-integration-of-red-nir-emissive-ceramic-like-anm6xi8xa6-metal-cluster-salts-in-organic-copolymers-using-supramolecular-interactions
#12
Yann Molard, Malo Robin, Noée Dumait, Maria Amela-Cortes, Claire Roiland, Maxime Harnois, Emmanuel Jacques, Hervé Folliot
Hybrid nanomaterials made of inorganic nanocomponents dispersed in an organic host raise an increasing interest as low-cost solution-processable functional materials. However, preventing phase segregation while allowing a high inorganic doping content remains a major challenge, and usual methods require a functionalization step prior integration. Herein, we report a new approach to design such nanocomposite in which lead-free and cadmium-free ceramic-like metallic nanocluster compounds are embedded at 10 wt % in organic copolymers, without any functionalization...
February 22, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29470842/elucidating-the-nature-of-the-excited-state-of-a-heteroleptic-copper-photosensitizer-using-time-resolved-x-ray-absorption-spectroscopy
#13
Dooshaye Moonshiram, Pablo Garrido-Barros, Carolina Gimbert-Suriñach, Antonio Picon, Cunming Liu, Xiaoyi Zhang, Michael Karnahl, Antoni Llobet
We report the light-induced electronic and geometric changes taking place within a heteroleptic Cu(I) photosensitizer, namely [(xant)Cu(Me2phenPh2)]PF6 (xant = xantphos, Me2phenPh2 = bathocuproine), by time-resolved X-ray absorption spectroscopy in the ps-µs time-regime. Time-resolved X-ray absorption near edge structure (XANES) and extended X-ray absorption fine structure (EXAFS) analysis enabled the elucidation of the electronic and structural configuration of the copper centre in the excited state as well as its decay dynamics in different solvent conditions with and without triethylamine acting as a sacrificial electron donor...
February 22, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29470664/toward-miniaturized-analysis-of-chemical-identity-and-purity-of-radiopharmaceuticals-via-microchip-electrophoresis
#14
Jimmy Ly, Noel S Ha, Shilin Cheung, R Michael van Dam
Miniaturized synthesis of positron emission tomography (PET) tracers is poised to offer numerous advantages including reduced tracer production costs and increased availability of diverse tracers. While many steps of the tracer production process have been miniaturized, there has been relatively little development of microscale systems for the quality control (QC) testing process that is required by regulatory agencies to ensure purity, identity, and biological safety of the radiotracer before use in human subjects...
February 22, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29470552/increased-hiv-1-transcriptional-activity-and-infectious-burden-in-peripheral-blood-and-gut-associated-cd4-t-cells-expressing-cd30
#15
Louise E Hogan, Joshua Vasquez, Kristen S Hobbs, Emily Hanhauser, Brandon Aguilar-Rodriguez, Rajaa Hussien, Cassandra Thanh, Erica A Gibson, Alexander B Carvidi, Louis C B Smith, Shahzada Khan, Martin Trapecar, Shomyseh Sanjabi, Ma Somsouk, Cheryl A Stoddart, Daniel R Kuritzkes, Steven G Deeks, Timothy J Henrich
HIV-1-infected cells persist indefinitely despite the use of combination antiretroviral therapy (ART), and novel therapeutic strategies to target and purge residual infected cells in individuals on ART are urgently needed. Here, we demonstrate that CD4+ T cell-associated HIV-1 RNA is often highly enriched in cells expressing CD30, and that cells expressing this marker considerably contribute to the total pool of transcriptionally active CD4+ lymphocytes in individuals on suppressive ART. Using in situ RNA hybridization studies, we show co-localization of CD30 with HIV-1 transcriptional activity in gut-associated lymphoid tissues...
February 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29470490/neutralization-of-cholera-toxin-with-nanoparticle-decoys-for-treatment-of-cholera
#16
Soumita Das, Pavimol Angsantikul, Christine Le, Denny Bao, Yukiko Miyamoto, Weiwei Gao, Liangfang Zhang, Lars Eckmann
Diarrheal diseases are a major cause of morbidity and mortality worldwide. In many cases, antibiotic therapy is either ineffective or not recommended due to concerns about emergence of resistance. The pathogenesis of several of the most prevalent infections, including cholera and enteroxigenic Escherichia coli, is dominated by enterotoxins produced by lumen-dwelling pathogens before clearance by intestinal defenses. Toxins gain access to the host through critical host receptors, making these receptors attractive targets for alternative antimicrobial strategies that do not rely on conventional antibiotics...
February 22, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29470403/cladodionen-a-cytotoxic-hybrid-polyketide-from-the-marine-derived-cladosporium-sp-oucmdz-1635
#17
Guoliang Zhu, Fandong Kong, Yi Wang, Peng Fu, Weiming Zhu
A new hybrid polyketide, cladodionen ( 1 ), together with a new abscisic acid analogue, cladosacid ( 2 ), were isolated from the marine-derived fungus, Cladosporium sp. OUCMDZ-1635. Their structures, including the absolute configurations, were fully elucidated on the basis of spectroscopic analysis, ECD spectra, quantum chemical calculations, and chemical methods. Cladodionen ( 1 ) showed cytotoxic activities against MCF-7, HeLa, HCT-116, and HL-60 human cancer cell lines with IC50 values of 18.7, 19.1, 17...
February 22, 2018: Marine Drugs
https://www.readbyqxmd.com/read/29470088/total-synthesis-and-stereochemical-revision-of-stereocalpin-a-mirror-image-approach-for-stereochemical-assignments-of-the-peptide-polyketide-macrocycle
#18
Masato Kaneda, Shinsuke Inuki, Hiroaki Ohno, Shinya Oishi
Stereocalpin A is a cyclic depsipeptide with cytotoxic activity isolated from the Antarctic lichen Stereocaulon alpinum. Although a number of synthetic investigations of the unprecedented 12-membered macrocycle of stereocalpin A with a dipeptide segment and a polyketide substructure have been conducted, the configurational assignment has not been completed. In this study, we achieved the first total synthesis and stereochemical revision of stereocalpin A. To facilitate the comprehensive assessment of eight possible stereocalpin A isomers, four stereoisomers of polyketide precursors were conjugated with L-Phe-L-MePhe and D-Phe-D-MePhe dipeptides to provide four possible isomers and four mirror-image structures of the remaining isomers, respectively...
February 22, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29470047/heterostructured-nanorings-of-fe-fe3o4-c-hybrid-with-enhanced-microwave-absorption-performance
#19
Xian Jian, Xiangyun Xiao, Longjiang Deng, Wei Tian, Xin Wang, Nasir Mahmood, Shixue Dou
Microwave absorption is a critical challenge with progression in electronics, where fine structural designing of absorbent materials plays an effective role in optimizing their microwave absorption properties. Here, we have developed Fe3O4@C (FC) and Fe-Fe3O4@C (FFC) hybrid nanorings via hydrothermal method coupled with chemical catalytic vapour deposition (CCVD) technique. FC and FFC hybrid nanorings have fine carbon coating while their size can easily be tuneable in a certain range from 80~130 nm and 90~140 nm, respectively...
February 22, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29470046/unravelling-the-structure-and-electrochemical-performance-of-li-cr-mn-o-cathode-from-spinel-to-layered
#20
Xuelei Li, Dan Li, Dawei Song, Xixi Shi, Xu Tang, Hongzhou Zhang, Lianqi Zhang
To explore new serials of cathode materials with high electrochemical performance, the spinel-layered (1-x)[LiCrMnO4 ]·x[Li2 MnO3 ·LiCrO2 ] (x = 0, 0.25, 0.5, 0.75 and 1) composites are synthesized with sol-gel method. XRD, HRTEM, SAED and Raman spectra reveal that the structures of the (1-x)[LiCrMnO4 ]·x[Li2 MnO3 ·LiCrO2 ] cathode materials evolve from spinel to hybrid spinel-layered and layered structure with the increase of the Li concentration. Test results reveals that the structure and electrochemical performance of (1-x)[LiCrMnO4 ]·x[Li2 MnO3 ·LiCrO2 ] (x = 0...
February 22, 2018: ACS Applied Materials & Interfaces
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