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Malignant ovarian germ cell tumor

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https://www.readbyqxmd.com/read/29286555/gonadal-dysgenesis-is-associated-with-worse-outcomes-in-patients-with-ovarian-nondysgerminomatous-tumors-a-report-of-the-children-s-oncology-group-agct-0132-study
#1
Bryan J Dicken, Deborah F Billmire, Mark Krailo, Caihong Xia, Furqan Shaikh, John W Cullen, Thomas A Olson, Farzana Pashankar, Marcio H Malogolowkin, James F Amatruda, Frederick J Rescorla, Rachel A Egler, Jonathan H Ross, Carlos Rodriguez-Galindo, A Lindsay Frazier
PURPOSE: In this report, we characterize the timing and behavior of malignant ovarian germ cell tumors (GCTs) in pediatric patients with dysgenetic gonads compared to those with normal gonadal development. PATIENTS AND METHODS: Patients from the Children's Oncology Group AGCT0132 with malignant ovarian GCTs were included. Within this population, we sought to identify patients with gonadoblastoma, streak ovaries, or other evidence of gonadal dysgenesis (GD). Patients with malignant GCTs containing one or more of the following histologies-yolk sac tumor, embryonal carcinoma, or choriocarcinoma-were included...
December 29, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29248013/fertility-sparing-surgery-in-advanced-stage-malignant-ovarian-germ-cell-tumor-a-case-report
#2
Montassar Ghalleb, Hatem Bouzaiene, Skander Slim, Achraf Hadiji, Monia Hechiche, Jamel Ben Hassouna, Khaled Rahal
BACKGROUND: Malignant ovarian germ cell tumor is a rare type of disease, which generally has a good prognosis due to the high chemosensitivity of this type of tumor. Fertility preservation is an important issue because malignant ovarian germ cell tumor commonly affects young women. Although conservation is the standard for early stage, it becomes more debatable as the disease progresses to more advanced stages. AIM: Report the case of a patient with an International Federation of Gynecology and Obstetrics Stage IIIc malignant ovarian germ cell tumor, who had conservative surgery and chemotherapy with a good fertility outcome...
December 17, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29227858/bilateral-ovarian-angiosarcoma-arising-from-the-mature-cystic-teratomas-a-case-report-and-review-of-the-literature
#3
Erik Kudela, Marcela Nachajova, Kamil Biringer, Pavol Slavik, Lukas Plank, Jan Danko
INTRODUCTION: Ovarian teratomas undergo the malignant transformation in 0.2-2% of cases. The behavior of malignancies in mature cystic teratomas (MCT) is determined by their phenotype and not their derivation from germ cells. We can recognize pure angiosarcomas or as a part of other tumors like malignant mixed Mullerian tumors and adenosarcomas. PRESENTATION OF CASE: We present the first case of bilateral ovarian angiosarcoma arising from the mature teratomas. Due to widespread disease, we performed limited surgical procedure consisting of bilateral adnexectomy and omentectomy...
December 7, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29227254/-modern-approaches-to-diagnosis-and-treatment-of-tumors-of-female-genitals-of-children-and-adolescents-review
#4
A Solopova, A Makatsaryia, O Yakovleva, V Moskvicheva
The article discusses the features of epidemiology, morphology, clinical course and modern principles of diagnostics and treatment of tumors of female genitals of children and adolescents. Special attention is paid to ovarian germ cell tumors. The use of immunohistochemical and tumor markers enables the differential diagnosis among malignant ovarian germ cell tumors. Nowadays surgical methods, chemotherapy and radiation therapy are applied in treatment of tumors of female genitals. The main standard of surgical operation of ovarian tumors is removal of appendages on the side of the affection...
November 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29198336/fertility-management-for-malignant-ovarian-germ-cell-tumors-patients
#5
REVIEW
Chiara Di Tucci, Assunta Casorelli, Elisa Morrocchi, Innocenza Palaia, Ludovico Muzii, Pierluigi Benedetti Panici
Malignant Germ Cell Tumors have primarily affecting adolescents and young adults. In advanced disease, greater than 70% of patients can be cured with standard chemotherapy regimens and fertility-sparing surgery appears to be safe with excellent survival after long-term follow-up. Due to their rarity, follow up and fertility management is largely based on trials of epithelial ovarian cancer or on few small studies. We report a review of the literature studies about the assessment, the monitoring and the treatment of fertility for Malignant Germ Cell Tumors as pratical guidelines for management of fertility in these patients...
December 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29194189/ovarian-yolk-sac-tumors-does-age-matter
#6
Cecile Faure Conter, Caihong Xia, David Gershenson, Jean Hurteau, Al Covens, Farzana Pashankar, Mark Krailo, Deborah Billmire, Catherine Patte, Brice Fresneau, Furqan Shaikh, Sara Stoneham, James Nicholson, Matthew Murray, Anne Lindsay Frazier
BACKGROUND: Whereas among pediatric oncologists, ovarian yolk sac tumor (O-YST) is considered a chemosensitive tumor, it is often cited as an adverse prognostic factor in adult women with ovarian germ cell tumors. METHODS: The Malignant Germ Cell International Consortium data set included 6 pediatric clinical trials (United States, United Kingdom, and France) and 2 adult gynecology clinical trials (United States). Any patient with an O-YST that was International Federation of Gynecology and Obstetrics stage IC or higher and treated with a platinum-based chemotherapy was eligible...
November 30, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29183227/malignant-mixed-germ-cell-tumor-overgrowing-a-gonadoblastoma-in-a-female-with-a-46-xx-karyotype-a-case-report
#7
Maria A Arafah, Leen E Raddaoui
Gonadoblastoma is an uncommon ovarian tumor arising primarily in females with gonadal dysgenesis and a 46, XY karyotype. Germ cell tumors arising within and/or overgrowing a gonadoblastoma have been reported. We report a rare case of a malignant mixed germ cell tumor (yolk sac tumor and choriocarcinoma) arising in a gonadoblastoma of the left ovary in a 19-year-old female with a 46, XX karyotype. The patient's initial α-fetoprotein level was 20 000 KIU/L. The patient underwent a laparoscopic unilateral salpingo-oophorectomy with omentectomy and peritoneal washing followed by adjuvant chemotherapy...
November 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29138809/microrna-expression-profiles-in-non%C3%A2-epithelial-ovarian-tumors
#8
Roger K Chang, Xidan Li, Ninni Mu, Olga Hrydziuszko, Beatriz Garcia-Majano, Catharina Larsson, Weng-Onn Lui
Ovarian germ cell tumors (OGCTs) and sex cord stromal tumors (SCSTs) are rare gynecologic tumors that are derived from germ and stromal cells, respectively. Unlike their epithelial counterparts, molecular pathogenesis of these tumor types is still poorly understood. Here, we characterized microRNA (miRNA) expression profiles of 9 OGCTs (2 malignant and 7 benign) and 3 SCSTs using small RNA sequencing. We observed significant miRNA expression variations among the three tumor groups. To further demonstrate the biological relevance of our findings, we selected 12 miRNAs for validation in an extended cohort of 16 OGCTs (9 benign and 7 malignant) and 7 SCSTs by reverse transcription-quantitative polymerase chain reaction...
November 10, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29113327/the-prevalence-of-malignant-and-borderline-ovarian-cancer-in-pre-and-post-menopausal-chinese-women
#9
Fang Shen, Shouzhen Chen, Yifei Gao, Xujing Dai, Qi Chen
The incidence of ovarian cancer depends on the ethnicity and geographical area. Menopausal status is a well-known risk factor for ovarian cancer and most cases occur after menopause in Caucasians. However, it is less clear how the status of menopause or age at diagnosis is associated with ovarian cancer including its subtypes in Chinese women. Data on 1,283 women with primary malignant or borderline ovarian cancer including age at diagnosis, age at menopause and histology from the largest women's hospital in China was analysed...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29062883/high-dose-chemotherapy-and-stem-cell-rescue-for-salvage-therapy-for-relapsed-malignant-mixed-ovarian-germ-cell-tumor-a-case-report
#10
Sarah Sears, Sareena Singh, Hadi Shojaei, Raymond Redline, Kimberly Resnick
BACKGROUND: Malignant ovarian germ cell tumors are rare, and often treatable with surgery and chemotherapy. Few data are available for treatment of platinum-resistant tumors. CASE: A 31 year old gravida 0 with a 20 cm pelvic mass was found to have a malignant ovarian germ cell tumor after she underwent debulking surgery. She initially responded to chemotherapy; however her AFP began to rise before all cycles were completed. She underwent additional debulking surgery that was again suboptimal...
November 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/29028099/the-diagnostic-value-of-determination-of-serum-golph3-associated-with-ca125-ca19-9-in-patients-with-ovarian-cancer
#11
H-Y Fan, D-M Duan, Y-F Liu
OBJECTIVE: To evaluate the value of three tumor markers serum Golgi phosphoprotein-3 (GOLPH3), cancer antigen 125 (CA125) and cancer antigen 19-9 (CA19.9) in the diagnosis and postoperative evaluation of ovarian cancer by detecting these three markers. PATIENTS AND METHODS: A total of 187 patients were studied and included in the ovarian cancer group, benign pelvic mass group, and the normal control group. The levels of serum Golgi phosphoprotein-3 (GOLPH3), cancer antigen 125 (CA125) and cancer antigen 199 (CA19...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29021083/fertility-preserving-surgery-for-advanced-stage-ovarian-germ-cell-tumors
#12
Dimitrios Nasioudis, Melissa K Frey, Eloise Chapman-Davis, Thomas A Caputo, Kevin Holcomb
OBJECTIVE: To evaluate the prevalence and safety of uterine preservation among premenopausal women diagnosed with a malignant ovarian germ-cell tumor (MOGCT) of advanced stage (stage II-IV). MATERIALS AND METHODS: The National Cancer Database was accessed and a cohort of women aged <40years, diagnosed with a MOGCT were identified. Those with stage II-IV disease who underwent cancer-directed surgery and received chemotherapy were selected for further analysis...
October 9, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28993225/treatment-approach-and-prognosis-of-pediatric-and-adolescent-non-epithelial-malignant-ovarian-tumors-a-retrospective-prognosis-analysis
#13
Peili Liang, Xin Zhang, Zhenfeng Zhang, Guocai Xu, Xingsu Yu, Sijin Li, Yuanyuan Zhang, Lijuan Bian, Bingzhong Zhang
BACKGROUND: Non-epithelial malignant ovarian tumors are rare in the pediatric and adolescent population. AIM: To observe the spectrum of pathology, presentation, outcome, and risk factors for survival of pediatric non-epithelial malignant ovarian tumors in a Chinese pediatric population. METHODS: This was a retrospective study of 171 girls (median age at presentation of 14 years) diagnosed with primary malignant ovarian tumors between 1990 and 2014 at the Yat-Sen Memorial Hospital and Cancer Center of Sun Yat-sen University...
October 6, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/28988685/socioeconomic-disparities-affect-survival-in-malignant-ovarian-germ-cell-tumors-in-aya-population
#14
L V Bownes, L L Stafman, I I Maizlin, M Dellinger, K W Gow, A B Goldin, M Goldfarb, M Langer, M V Raval, J J Doski, J G Nuchtern, S A Vasudevan, E A Beierle
BACKGROUND: Malignant ovarian germ cell tumors (MOGCTs) are a rare form of ovarian malignancy. Socioeconomic status (SES) has been shown to affect survival in several gynecologic cancers. We examined whether SES impacted survival in adolescent and young adults (AYAs) with MOGCT. MATERIALS AND METHODS: The National Cancer Data Base was used to identify AYAs (aged 15-39 years) with MOGCT from 1998 to 2012. Three SES surrogate variables identified were as follows: insurance type, income quartile, and education quartile...
October 5, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28919321/clinicopathological-pattern-and-outcome-of-pediatric-malignant-ovarian-germ-cell-tumors-south-egypt-cancer-institute-experience
#15
Amany Ali, Heba Sayed, Mohamed Salem, Mohamed Hamdy, Amro Farok
BACKGROUND: Malignant ovarian germ cell tumors (MOGCTs) are rare and represent 1-1.5% of all cancers in children and adolescents. The aim of this study is to analyze the clinicopathological pattern at presentation and management and outcome of MOGCTs in children and adolescents. PATIENTS AND METHODS: Retrospective study included all girls diagnosed with MOGCTs between January 2005 and January 2015 in Pediatric and Surgical Oncology Departments at South Egypt Cancer Institute, Assiut University...
September 1, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28900333/ruptured-malignant-ovarian-tumor-in-an-adolescent-girl-a-rare-case-report
#16
Kanika Chopra, Swati Agrawal, Kiran Aggarwal, Ratna Biswas
Germ cell tumors which arise mainly in pediatric and adolescent age group, account for 30% of all ovarian tumors, but constitute only 5% of all malignant ovarian tumors. The presentation is usually insidious with the patient presenting with abdominal swelling and dull aching pain. We report a rare case of a malignant germ cell tumor in a 12-year-old girl who presented with acute abdomen due to spontaneous rupture of tumor resulting in hemoperitoneum. The patient was taken up for emergency laparotomy and left salpingo-opherectomy with omentectomy and drainage of hemoperitoneum was done...
April 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/28843226/pregnancy-outcomes-after-conservative-surgery-for-early-stage-ovarian-neoplasms
#17
Panwad Ratanasrithong, Mongkol Benjapibal
Objective: This retrospective, single institute study aimed to evaluate pregnancy and oncologic outcomes in reproductive-age Thai women with early-stage ovarian neoplasms undergoing conservative surgical treatment. Methods: Medical records of 84 women of reproductive age (15-45 years) with histologically confirmed early-stage (IA-IIC) borderline ovarian tumors or cancers who had undergone conservative surgery between January 2003 and December 2012 were retrospectively reviewed. Results: The mean age of patients at diagnosis was 28...
August 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28832426/different-features-of-the-histopathological-subtypes-of-ovarian-tumors-in-pre-and-postmenopausal-women
#18
Eun Jung Jung, Hye Mi Eom, Jung Mi Byun, Young Nam Kim, Kyung Bok Lee, Moon Su Sung, Ki Tae Kim, Dae Hoon Jeong
OBJECTIVE: To date, epidemiological evidence has consistently supported a link between ovarian cancer risk and menopause. However, little is known about how menopause status affects the risk of specific histological subtypes of ovarian tumors. We aimed to analyze the differences in various histopathological subtypes of ovarian tumors between pre- and postmenopausal women. METHODS: We reviewed the medical records of women who underwent surgery for ovarian tumors and received histopathological confirmation at the Busan Paik Hospital between January 1997 and October 2016...
September 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28819483/-malignant-teratoma-about-a-case-and-a-review-of-the-literature
#19
REVIEW
Abdi Ahmed Bonahy, Houssam Sabbah, Ahmed Haiba Med Vadell, Nacer Eddine Med Baba
Dermoid cysts account for 10-20% of ovarian germ cell tumors. Malignant transformation within ovarian dermoid cyst has been reported in 1-2 per cent of the cases. The treatment remains controversial. In women of childbearing age and in the first stages of the disease unilateral annexectomy without adjuvant therapy is recommended. In menopausal women extensive surgery is sometimes performed, no matter what stage of the disease the person is experiencing. We report the case of a menopausal patient with malignant transformation within ovarian dermoid cyst who underwent surgery...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28750644/a-retrospective-study-of-reproductive-outcomes-after-fertility-sparing-surgery-and-postoperative-adjuvant-chemotherapy-in-malignant-ovarian-germ-cell-tumors-and-sex-cord-stromal-tumors
#20
Ning Zhang, Ruifang Chen, Keqin Hua, Ying Zhang
BACKGROUND: To retrospectively investigate reproductive outcomes after fertility-sparing surgery and postoperative adjuvant chemotherapy in malignant ovarian germ cell tumors (MOGCT) and sex cord-stromal tumors (SCST). METHODS: Data from 32 MOGCT (6 dysgerminomas, 6 yolk sac tumors, 17 immature teratomas, and 3 mixed germ cell tumors) and 9 SCST (4 granulosa cell tumors and 5 sertoli-leydig cell tumors) aged from 18 to 35, treated in the Obstetrics and Gynecology Hospital of Fudan University from October 2003 to October 2013 were collected and analyzed...
July 27, 2017: Journal of Ovarian Research
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