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Malignant ovarian germ cell tumor

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https://www.readbyqxmd.com/read/27818263/brief-report-a-second-primary-endodermal-sinus-tumor-nine-years-after-initial-diagnosis
#1
Lea A Moukarzel, Kimberly Levinson, Francis C Grumbine
BACKGROUND: Ovarian yolk sac tumors (YST) are rare malignant germ cell tumors known to present unilaterally, allowing for fertility sparing surgical treatment with adjuvant chemotherapy. The few published cases of bilateral ovarian involvement were at the time of original diagnosis in patients with widely metastatic disease. We present this first case of bilateral ovarian YSTs, diagnosed several years apart, and discuss the implications on recurrence and tumor marker surveillance for these tumors...
November 3, 2016: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/27803008/the-role-of-staging-and-adjuvant-chemotherapy-in-stage-i-malignant-ovarian-germ-cell-tumors-mogts-the-mito-9-study
#2
G Mangili, C Sigismondi, D Lorusso, G Cormio, M Candiani, G Scarfone, F Mascilini, A Gadducci, A M Mosconi, P Scollo, C Cassani, S Pignata, G Ferrandina
BACKGROUND: Surgery followed by platinum-based chemotherapy is the standard of care for MOGCTs, except for stage IA dysgerminoma and stage IA grade 1 immature teratoma where surveillance only is recommended. The role of adjuvant chemotherapy and surgical staging is debated. PATIENTS AND METHODS: Data from 144 patients with stage I MOGTs were collected among MITO centers (Multicenter Italian Trials in Ovarian Cancer) and analysed. RESULTS: 55(38...
November 1, 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/27785897/complete-response-to-paclitaxel-ifosfamide-and-cisplatin-therapy-in-a-case-of-ovarian-ependymoma
#3
Makiko Hino, Yusuke Kobayashi, Michiko Wada, Yoshihisa Hattori, Takashi Kurahasi, Hiroyuki Nakagawa
There are many reports on paclitaxel, ifosfamide, and cisplatin (TIP) therapy, following standard bleomycin, etoposide, and cisplatin (BEP) therapy, for salvage treatment of testicular malignant germ cell tumors, but there are no reports on its use for ovarian malignant tumors. We report here that a patient with primary ependymoma of the ovary, who was resistant to BEP therapy, achieved a complete response to a combined therapy, including TIP therapy as the second-line chemotherapy and surgery. This important case, combined with published studies, suggests that TIP therapy is effective for both testicular and ovarian malignant tumors and indicates that TIP therapy can be used as an effective second-line therapy for malignant tumors resistant to BEP therapy...
November 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27781377/a-variant-c-kit-mutation-d816h-fundamental-to-the-sequential-development-of-an-ovarian-mixed-germ-cell-tumor-and-systemic-mastocytosis-with-cmml
#4
Sarah G Mitchell, Silvia T Bunting, Debra Saxe, Thomas Olson, Frank G Keller
An activating point mutation of the c-KIT tyrosine kinase receptor gene, D816H, has been described in germ cell tumors (GCTs). We report an adolescent diagnosed with an ovarian mixed GCT and systemic mastocytosis with chronic myelomonocytic leukemia (SM-CMML). The teratoma and dysgerminoma differed by copy number aberrations via single nucleotide polymorphism (SNP) microarray, but were inclusive of the same c-KIT D816H point mutation (c.2446G>C) also identified in blood and bone marrow mast cells. These findings indicate not only a clonal origin of the GCT and hematologic malignancy, but also suggest a rare KIT mutation may be playing a fundamental role in malignancy development...
October 26, 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27757372/ovarian-mature-cystic-teratoma-with-fistula-formation-into-the-rectum-a-case-report
#5
Yuichiro Kizaki, Tomonori Nagai, Ken Ohara, Yosuke Gomi, Taichi Akahori, Yoshihisa Ono, Shigetaka Matsunaga, Yasushi Takai, Masahiro Saito, Kazunori Baba, Hiroyuki Seki
BACKGROUND: While ovarian mature cystic teratomas are benign ovarian germ-cell tumors and the most common type of all ovarian tumors, the formation of fistulas into surrounding organs such as the bladder and the intestinal tract is extremely rare. This report documents a case of ovarian mature cystic teratoma with a rectal fistula, thought to be caused by local inflammation. CASE DESCRIPTION: A pelvic mass was diagnosed as an ovarian mature cystic teratoma of approximately 10 cm in diameter on transvaginal ultrasound and magnetic resonance examinations...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27704516/prognostic-factors-in-children-with-extracranial-malignant-germ-cell-tumors-a-monocentric-pediatric-tunisian-study
#6
Faten Fedhila, Samar Rhayem, Habiba Hafsi, Wiem Douira, Raoudha Doghri, Monia Khemiri, Karima Mrad, Ibtissem Bellagha, Bechir Zouari, Sihem Barsaoui
Background Extracranial Germ cell tumors (GCT) are a rare and a heterogeneous group of pediatric cancers but highly curable. Aim We aimed to review management, outcome and prognostic factors that influence overall survival (OS) in a pediatric Tunisian oncologic unit. Methods We retrospectively evaluated between January 1998 and December 2012, 33 patients affected by extracranial germ cell tumors and treated according to TGM95 protocol established by the SFOPin a pediatric Tunisian oncologic unit. Results Patients had a mean age of 57 months (ranges: 1 day-13 years)...
April 2016: La Tunisie Médicale
https://www.readbyqxmd.com/read/27595361/germ-cell-tumors-in-adolescents-and-young-adults
#7
Gabriele Calaminus, Jonathan Joffe
Germ cell tumors (GCTs) represent a group of biologically complex malignancies that affect patients at different sites within the body and at different ages. The varying nature of these tumors reflects their cell of origin which is the primordial germ cell, which normally gives rise to ovarian and testicular egg and sperm producing cells. These cells retain an ability to give rise to all types of human tissues, and this is illustrated by the different kinds of GCTs that occur. In adolescent and young adult (AYA) patients, GCTs predominantly present as testicular, ovarian or mediastinal primary GCTs, and represent some of the most complex therapeutic challenges within any AYA practice...
2016: Progress in Tumor Research
https://www.readbyqxmd.com/read/27587625/ovarian-cancer-version-1-2016-nccn-clinical-practice-guidelines-in-oncology
#8
Robert J Morgan, Deborah K Armstrong, Ronald D Alvarez, Jamie N Bakkum-Gamez, Kian Behbakht, Lee-May Chen, Larry Copeland, Marta Ann Crispens, Maria DeRosa, Oliver Dorigo, David M Gershenson, Heidi J Gray, Ardeshir Hakam, Laura J Havrilesky, Carolyn Johnston, Shashikant Lele, Lainie Martin, Ursula A Matulonis, David M O'Malley, Richard T Penson, Sanja Percac-Lima, Mario Pineda, Steven C Plaxe, Matthew A Powell, Elena Ratner, Steven W Remmenga, Peter G Rose, Paul Sabbatini, Joseph T Santoso, Theresa L Werner, Jennifer Burns, Miranda Hughes
This selection from the NCCN Guidelines for Ovarian Cancer focuses on the less common ovarian histopathologies (LCOHs), because new algorithms were added for LCOHs and current algorithms were revised for the 2016 update. The new LCOHs algorithms include clear cell carcinomas, mucinous carcinomas, and grade 1 (low-grade) serous carcinomas/endometrioid epithelial carcinomas. The LCOHs also include carcinosarcomas (malignant mixed Müllerian tumors of the ovary), borderline epithelial tumors (also known as low malignant potential tumors), malignant sex cord-stromal tumors, and malignant germ cell tumors...
September 2016: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/27569583/conundrums-in-the-management-of-malignant-ovarian-germ-cell-tumors-toward-lessening-acute-morbidity-and-late-effects-of-treatment
#9
David M Gershenson, A Lindsay Frazier
One of the most extraordinary stories in the chronicles of gynecologic cancers has been that of malignant ovarian germ cell tumors. Prior to the mid-1960s, most patients died of disease. Fifty years later, most survive. Precisely because high cure rates are achievable, the concentration over the past decade has been on minimizing toxicity and late effects. The present review focuses on five areas of interest related to the management of malignant ovarian germ cell tumors that highlight the different therapeutic strategies practiced by pediatric and gynecologic oncologists: 1) primary surgery, 2) surgery alone (surveillance) for patients with FIGO stage IA disease, 3) postoperative management of FIGO stage IC-III disease, 4) postoperative management of pure immature teratoma, and 5) postoperative management of metastatic pure dysgerminoma...
November 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27569298/perspectives-on-testicular-germ-cell-neoplasms
#10
Liang Cheng, Bingjian Lyu, Lawrence M Roth
Our knowledge of testicular germ cell neoplasms has progressed in the last few decades due to the description of germ cell neoplasia in situ (GCNIS) and a variety of specific forms of intratubular germ cell neoplasia, the discovery of isochromosome 12p and its importance in the development of invasiveness in germ cell tumors (GCTs), the identification of specific transcription factors for GCTs, and the recognition that a teratomatous component in mixed GCT represents terminal differentiation. Isochromosome 12p and 12p overrepresentation, collectively referred to as 12p amplification, are fundamental abnormalities that account for many types of malignant GCTs of the testis...
August 25, 2016: Human Pathology
https://www.readbyqxmd.com/read/27474440/loss-of-l-3-mbt-leads-to-acquisition-of-the-ping-pong-cycle-in-drosophila-ovarian-somatic-cells
#11
Tetsutaro Sumiyoshi, Kaoru Sato, Hitomi Yamamoto, Yuka W Iwasaki, Haruhiko Siomi, Mikiko C Siomi
In Drosophila germ cells, PIWI-interacting RNAs (piRNAs) are amplified through a PIWI slicer-dependent feed-forward loop termed the ping-pong cycle, yielding secondary piRNAs. However, the detailed mechanism remains poorly understood, largely because an ex vivo model system amenable to biochemical analyses has not been available. Here, we show that CRISPR-mediated loss of function of lethal (3) malignant brain tumor [l(3)mbt] leads to ectopic activation of the germ-specific ping-pong cycle in ovarian somatic cells...
July 15, 2016: Genes & Development
https://www.readbyqxmd.com/read/27462604/a-case-report-of-a-young-girl-with-mucinous-borderline-tumor-of-the-ovary
#12
Hyun-Mi Lee, Kyeong A So, Mi Kyung Kim, Yoo Kyung Lee, In-Ho Lee, Tae-Jin Kim, Ki Heon Lee
Ovarian tumors are relatively rare in children and adolescent. The incidence of malignancies in these groups is 1% to 1.5%. The common histologic type is non-epithelial type such as germ cell tumors or sex cord-stromal tumors and only 10% to 17% of those are epithelial tumors. It is important to accurately diagnose in the early these rare tumors for proper staging and treatment to save the patient's life and fertility. We present a case of a 13-year-old girl with a giant ovarian mucinous borderline tumor.
July 2016: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/27446585/management-of-bilateral-malignant-ovarian-germ-cell-tumors-experience-of-a-single-institute
#13
Ting Zhao, Yan Liu, Hongyuan Jiang, Hao Zhang, Yuan Lu
Bilateral malignant ovarian germ cell tumors (MOGCTs) are rare. Determination of the optimal treatment modalities is crucial, as these malignancies mainly affect girls and young women who may wish to preserve their fertility. In order to review the prevalence, clinical characteristics, treatment and outcome of bilateral MOGCTs, we performed a retrospective review of patients who were diagnosed with bilateral MOGCTs and underwent primary surgery at the Obstetrics and Gynecology Hospital of Fudan University (Shanghai, China) between January, 2001 and December, 2014...
August 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27421754/adnexal-masses-in-children-adolescents-and-women-of-reproductive-age-in-the-netherlands-a-nationwide-population-based-cohort-study
#14
Ayke J Hermans, Kirsten B Kluivers, Laura M Janssen, Albert G Siebers, Marc H W A Wijnen, Johan Bulten, Leon F A G Massuger, Sjors F P J Coppus
OBJECTIVE: To provide an accurate incidence of adnexal masses in children and young women which can significantly improve the performance of current risk prediction models. METHODS: We used the PALGA database, a nationwide network and registry of histopathology and cytopathology, as the primary source of our study. Reports on ovarian histology of girls, years 1991-2014, and women aged 21-39, years 2011-2013, were included. Reports were labeled using the WHO-classification and classified as benign, borderline malignant, or malignant...
October 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27411466/swyer-s-syndrome-with-mixed-ovarian-malignant-germ-cell-tumor-and-ovarian-gonadoblastoma
#15
Hong-Lan Zhu, Dong-Mei Bao, Yue Wang, Dan-Hua Shen, Yi Li, Heng Cui
No abstract text is available yet for this article.
July 20, 2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27401840/prognostic-significance-of-an-early-decline-in-serum-alpha-fetoprotein-during-chemotherapy-for-ovarian-yolk-sac-tumors
#16
Thibault de la Motte Rouge, Patricia Pautier, Catherine Genestie, Annie Rey, Sébastien Gouy, Alexandra Leary, Christine Haie-Meder, Pierre Kerbrat, Stéphane Culine, Karim Fizazi, Catherine Lhommé
BACKGROUND: The ovarian yolk sac tumor (OYST) is a very rare malignancy arising in young women. Our objective was to determine whether an early decline in serum alpha-fetoprotein (AFP) during chemotherapy has a prognostic impact. METHODS: This retrospective study is based on prospectively recorded OYST cases at Gustave Roussy (Cancer Treatment Center). Survival curves were estimated using the Kaplan-Meier method. The serum AFP decline was calculated with the formula previously developed and validated in male patients with poor prognosis non-seminomatous germ cell tumors...
September 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27357180/current-strategy-for-the-treatment-of-ovarian-germ-cell-tumors-role-of-extensive-surgery
#17
REVIEW
Jin Li, Xiaohua Wu
The necessity and extent of comprehensive surgical staging (CSS) and lymphadenectomy in the treatment of malignant ovarian germ cell tumors (MOGCTs) is still controversial. However, it is uniformly agreed that CSS with lymphadenectomy is crucial to follow up patients without adjuvant chemotherapy in stage I MOGCTs. Considering the chemotherapy-sensitive nature of MOGCTs, fertility-sparing cytoreductive surgery (FSCS) seems a reasonable approach in initial treatment for patients with advanced stage. When encountered with bilateral MOGCTs, debulking is surely granted if there is no desire for fertility...
August 2016: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/27303655/ovarian-teratoma-displaying-a-wide-variety-of-tissue-components-in-a-broiler-chicken-gallus-domesticus-morphological-heterogeneity-of-pluripotential-germ-cell-during-tumorigenesis
#18
S Ohfuji
Spontaneous ovarian teratoma was found in a seven-week-old female Chunky broiler chicken that was slaughtered for food. On post-mortem inspection, a spherical tumor mass attaching to a juvenile ovary was found in the abdominal cavity. Histopathologically, the tumor was comprised of immature mesenchymal stroma and a variety of mature tissue elements of mesodermal and ectodermal origin. In addition, there were multiple indistinguishable tissue elements, which showed no malignant cytological features but were unidentifiable as to corresponding embryological layer of origin...
2016: Open veterinary journal
https://www.readbyqxmd.com/read/27262834/laparoscopic-treatment-of-mixed-malignant-ovarian-germ-cell-tumor-in-a-16-year-old-female-adolescent
#19
Caroline Friedman, Tamatha Fenster
BACKGROUND: Malignant ovarian germ cell tumors are rare entities, although they account for a large proportion of ovarian masses in young women. These tumors have traditionally been removed via laparotomy, because of their large size and solid nature. The use of laparoscopy for treatment of adnexal masses in adolescents has been heavily debated and poorly studied to date. CASE: A 16-year-old female patient presented with abdominal pain and an 11-cm adnexal mass on ultrasound...
June 1, 2016: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/27258729/how-common-is-the-growing-teratoma-syndrome-in-patients-with-ovarian-immature-teratoma
#20
Julie My Van Nguyen, Genevieve Bouchard-Fortier, Sarah E Ferguson, Allan Covens
OBJECTIVES: Growing teratoma syndrome (GTS) after adjuvant chemotherapy for ovarian germ cell tumors is uncommon, with approximately 60 cases reported in the English literature. The objective of this study was to report clinical parameters including outcomes of patients with a diagnosis of GTS after adjuvant chemotherapy for ovarian immature teratoma (IT). METHODS AND MATERIALS: Patients with a condition diagnosed as ovarian IT between 1999 and 2014 at 2 tertiary-care academic centers were evaluated for the development of GTS...
September 2016: International Journal of Gynecological Cancer
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