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Malignant ovarian germ cell tumor

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https://www.readbyqxmd.com/read/29768344/synchronous-adrenocortical-carcinoma-and-ovarian-malignant-mixed-germ-cell-tumor-a-case-report-and-literature-review
#1
Ying He, Lian Xu, Qingli Li, Min Feng, Wei Wang
RATIONALE: Adrenocortical carcinoma (ACC) is an endocrine malignancy with poor prognosis, which commonly arises in a sporadic manner, but may also become a part of a familial syndrome. ACC rarely arises simultaneously with other malignant tumors. PATIENT CONCERNS: We report a case of a 29-year-old woman with ACC synchronously followed by an ovarian malignant mixed germ cell tumor. We describe the clinical, histopathological, and immunohistochemical findings and review the English literatures...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29673667/the-role-of-preoperative-serum-cancer-antigen-125-in-malignant-ovarian-germ-cell-tumors
#2
Ju-Hyun Kim, Jeong-Yeol Park, Jong-Hyeok Kim, Yong-Man Kim, Young-Tak Kim, Joo-Hyun Nam
OBJECTIVE: To determine the role of preoperative serum cancer antigen 125 (CA 125) in malignant ovarian germ cell tumors (MOGCTs). MATERIALS AND METHODS: Using information from medical databases of Asan Medical Center (Seoul, Korea), we investigated 161 patients with histologically diagnosed MOGCTs and whose preoperative serum CA 125 had been checked. We determined the optimal cutoff value of CA 125 as > 249.5 U/mL in MOGCTs using a receiver operating characteristic curve...
April 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29580145/ovarian-dysgerminoma-in-pregnancy-a-case-report-and-literature-review
#3
Yuanyuan Chen, Ying Luo, Cha Han, Wenyan Tian, Wen Yang, Yingmei Wang, Fengxia Xue
BACKGROUND: Dysgerminoma is an uncommon malignant tumor arising from the germ cells of the ovary. Its association with pregnancy is extremely rare; the incidence is about 0.2-1 per 100,000 pregnancies. Because of its infrequency, there are few recommendations regarding its management in pregnancy; therefore, it is important to discuss and summarize the treatment strategy. CASE: We presented a case of a 23-year-old pregnant woman with a large dysgerminoma originated from the right ovary, which had the unusual coincidence of being associated with an abdominal desmoid tumor simultaneously...
March 26, 2018: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/29531580/histopathological-pattern-and-age-distribution-of-malignant-ovarian-tumor-among-sudanese-ladies
#4
Sumeya A Kheiri, Abdelillah Kunna, Ali Yousif Babiker, Sultan A Alsuhaibani, Rami Yousif Ahmed, Mohamed Alkhatim Alsammani
INTRODUCTION: Ovarian cancer is the cause of a high case-fatality ratio, and most of the cases are diagnosed in late stages. OBJECTIVES: To determine the histopathological types, age distribution, and ovarian tumour stages among diagnosed with ovarian cancer at Al - Amal Tower a multi-referral polyclinic of Radiology & Isotope Center Khartoum (RICK), Sudan. METHODS: All histopathology reports patients' case from January to June 2015 were reviewed...
February 15, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29509324/erratum-pashankar-f-hale-jp-dang-h-et-al-is-adjuvant-chemotherapy-indicated-in-ovarian-immature-teratomas-a-combined-data-analysis-from-the-malignant-germ-cell-tumor-international-collaborative-cancer-2016-122-230-237
#5
https://www.readbyqxmd.com/read/29453163/incidentally-discovered-persistent-m%C3%A3-llerian-duct-syndrome-in-a-45-year-old-male-presenting-with-germ-cell-tumor-and-bilateral-cryptorchidism-a-rare-case-report-and-review-of-the-literature
#6
Turki Z Al Harbi, Kareem Ayman Azzam, Ayman Azzam, Tarek Amin, Nasir Bakshi
INTRODUCTION: Persistent Müllerian Duct Syndrome (PMDS) is a rare sexual disease. It is characterized by the presence of female reproductive structures such as uterus, cervix, fallopian tubes and upper part of vagina in a normal genotypically and phenotypically male. The diagnosis is usually incidental since the patients will present with normal external genitalia and secondary sexual characteristics. Imaging techniques such as magnetic resonance imaging (MRI), computed tomography (CT) scan, or ultrasound (US) could help in the diagnosis...
2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29399351/extremely-large-epithelial-ovarian-cancer-associated-with-pregnancy-a-case-report
#7
Viktoria Husz, Dorottya Bus, Gyorgy Vajda
Ovarian malignancies are rare in pregnancy; however, the incidence of abnormal adnexal masses diagnosed during pregnancy is increasing. The most common masses are ovarian cysts, and only 3-6% of those are malignant. The majority of ovarian masses are diagnosed at an early stage by routine ultrasound examinations. Malignant germ cell tumors are the most common ovarian malignancies associated with pregnancy, while the incidence of epithelial ovarian cancer is only 1:12,000-1:50,000 of pregnancies. The diagnosis and management of ovarian cancer during pregnancy remain unclear due to the rare occurrence and scant data on this condition...
January 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29286555/gonadal-dysgenesis-is-associated-with-worse-outcomes-in-patients-with-ovarian-nondysgerminomatous-tumors-a-report-of-the-children-s-oncology-group-agct-0132-study
#8
Bryan J Dicken, Deborah F Billmire, Mark Krailo, Caihong Xia, Furqan Shaikh, John W Cullen, Thomas A Olson, Farzana Pashankar, Marcio H Malogolowkin, James F Amatruda, Frederick J Rescorla, Rachel A Egler, Jonathan H Ross, Carlos Rodriguez-Galindo, A Lindsay Frazier
PURPOSE: In this report, we characterize the timing and behavior of malignant ovarian germ cell tumors (GCTs) in pediatric patients with dysgenetic gonads compared to those with normal gonadal development. PATIENTS AND METHODS: Patients from the Children's Oncology Group AGCT0132 with malignant ovarian GCTs were included. Within this population, we sought to identify patients with gonadoblastoma, streak ovaries, or other evidence of gonadal dysgenesis (GD). Patients with malignant GCTs containing one or more of the following histologies-yolk sac tumor, embryonal carcinoma, or choriocarcinoma-were included...
April 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29248013/fertility-sparing-surgery-in-advanced-stage-malignant-ovarian-germ-cell-tumor-a-case-report
#9
Montassar Ghalleb, Hatem Bouzaiene, Skander Slim, Achraf Hadiji, Monia Hechiche, Jamel Ben Hassouna, Khaled Rahal
BACKGROUND: Malignant ovarian germ cell tumor is a rare type of disease, which generally has a good prognosis due to the high chemosensitivity of this type of tumor. Fertility preservation is an important issue because malignant ovarian germ cell tumor commonly affects young women. Although conservation is the standard for early stage, it becomes more debatable as the disease progresses to more advanced stages. AIM: Report the case of a patient with an International Federation of Gynecology and Obstetrics Stage IIIc malignant ovarian germ cell tumor, who had conservative surgery and chemotherapy with a good fertility outcome...
December 17, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29227858/bilateral-ovarian-angiosarcoma-arising-from-the-mature-cystic-teratomas-a-case-report-and-review-of-the-literature
#10
Erik Kudela, Marcela Nachajova, Kamil Biringer, Pavol Slavik, Lukas Plank, Jan Danko
INTRODUCTION: Ovarian teratomas undergo the malignant transformation in 0.2-2% of cases. The behavior of malignancies in mature cystic teratomas (MCT) is determined by their phenotype and not their derivation from germ cells. We can recognize pure angiosarcomas or as a part of other tumors like malignant mixed Mullerian tumors and adenosarcomas. PRESENTATION OF CASE: We present the first case of bilateral ovarian angiosarcoma arising from the mature teratomas. Due to widespread disease, we performed limited surgical procedure consisting of bilateral adnexectomy and omentectomy...
2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29227254/-modern-approaches-to-diagnosis-and-treatment-of-tumors-of-female-genitals-of-children-and-adolescents-review
#11
A Solopova, A Makatsaryia, O Yakovleva, V Moskvicheva
The article discusses the features of epidemiology, morphology, clinical course and modern principles of diagnostics and treatment of tumors of female genitals of children and adolescents. Special attention is paid to ovarian germ cell tumors. The use of immunohistochemical and tumor markers enables the differential diagnosis among malignant ovarian germ cell tumors. Nowadays surgical methods, chemotherapy and radiation therapy are applied in treatment of tumors of female genitals. The main standard of surgical operation of ovarian tumors is removal of appendages on the side of the affection...
November 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29198336/fertility-management-for-malignant-ovarian-germ-cell-tumors-patients
#12
REVIEW
Chiara Di Tucci, Assunta Casorelli, Elisa Morrocchi, Innocenza Palaia, Ludovico Muzii, Pierluigi Benedetti Panici
Malignant Germ Cell Tumors have primarily affecting adolescents and young adults. In advanced disease, greater than 70% of patients can be cured with standard chemotherapy regimens and fertility-sparing surgery appears to be safe with excellent survival after long-term follow-up. Due to their rarity, follow up and fertility management is largely based on trials of epithelial ovarian cancer or on few small studies. We report a review of the literature studies about the assessment, the monitoring and the treatment of fertility for Malignant Germ Cell Tumors as pratical guidelines for management of fertility in these patients...
December 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29194189/ovarian-yolk-sac-tumors-does-age-matter
#13
Cecile Faure Conter, Caihong Xia, David Gershenson, Jean Hurteau, Al Covens, Farzana Pashankar, Mark Krailo, Deborah Billmire, Catherine Patte, Brice Fresneau, Furqan Shaikh, Sara Stoneham, James Nicholson, Matthew Murray, Anne Lindsay Frazier
BACKGROUND: Whereas among pediatric oncologists, ovarian yolk sac tumor (O-YST) is considered a chemosensitive tumor, it is often cited as an adverse prognostic factor in adult women with ovarian germ cell tumors. METHODS: The Malignant Germ Cell International Consortium data set included 6 pediatric clinical trials (United States, United Kingdom, and France) and 2 adult gynecology clinical trials (United States). Any patient with an O-YST that was International Federation of Gynecology and Obstetrics stage IC or higher and treated with a platinum-based chemotherapy was eligible...
January 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29183227/malignant-mixed-germ-cell-tumor-overgrowing-a-gonadoblastoma-in-a-female-with-a-46-xx-karyotype-a-case-report
#14
Maria A Arafah, Leen E Raddaoui
Gonadoblastoma is an uncommon ovarian tumor arising primarily in females with gonadal dysgenesis and a 46, XY karyotype. Germ cell tumors arising within and/or overgrowing a gonadoblastoma have been reported. We report a rare case of a malignant mixed germ cell tumor (yolk sac tumor and choriocarcinoma) arising in a gonadoblastoma of the left ovary in a 19-year-old female with a 46, XX karyotype. The patient's initial α-fetoprotein level was 20 000 KIU/L. The patient underwent a laparoscopic unilateral salpingo-oophorectomy with omentectomy and peritoneal washing followed by adjuvant chemotherapy...
November 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29138809/microrna-expression-profiles-in-non%C3%A2-epithelial-ovarian-tumors
#15
Roger K Chang, Xidan Li, Ninni Mu, Olga Hrydziuszko, Beatriz Garcia-Majano, Catharina Larsson, Weng-Onn Lui
Ovarian germ cell tumors (OGCTs) and sex cord stromal tumors (SCSTs) are rare gynecologic tumors that are derived from germ and stromal cells, respectively. Unlike their epithelial counterparts, molecular pathogenesis of these tumor types is still poorly understood. Here, we characterized microRNA (miRNA) expression profiles of 9 OGCTs (2 malignant and 7 benign) and 3 SCSTs using small RNA sequencing. We observed significant miRNA expression variations among the three tumor groups. To further demonstrate the biological relevance of our findings, we selected 12 miRNAs for validation in an extended cohort of 16 OGCTs (9 benign and 7 malignant) and 7 SCSTs by reverse transcription-quantitative polymerase chain reaction...
January 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29113327/the-prevalence-of-malignant-and-borderline-ovarian-cancer-in-pre-and-post-menopausal-chinese-women
#16
Fang Shen, Shouzhen Chen, Yifei Gao, Xujing Dai, Qi Chen
The incidence of ovarian cancer depends on the ethnicity and geographical area. Menopausal status is a well-known risk factor for ovarian cancer and most cases occur after menopause in Caucasians. However, it is less clear how the status of menopause or age at diagnosis is associated with ovarian cancer including its subtypes in Chinese women. Data on 1,283 women with primary malignant or borderline ovarian cancer including age at diagnosis, age at menopause and histology from the largest women's hospital in China was analysed...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29062883/high-dose-chemotherapy-and-stem-cell-rescue-for-salvage-therapy-for-relapsed-malignant-mixed-ovarian-germ-cell-tumor-a-case-report
#17
Sarah Sears, Sareena Singh, Hadi Shojaei, Raymond Redline, Kimberly Resnick
BACKGROUND: Malignant ovarian germ cell tumors are rare, and often treatable with surgery and chemotherapy. Few data are available for treatment of platinum-resistant tumors. CASE: A 31 year old gravida 0 with a 20 cm pelvic mass was found to have a malignant ovarian germ cell tumor after she underwent debulking surgery. She initially responded to chemotherapy; however her AFP began to rise before all cycles were completed. She underwent additional debulking surgery that was again suboptimal...
November 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/29028099/the-diagnostic-value-of-determination-of-serum-golph3-associated-with-ca125-ca19-9-in-patients-with-ovarian-cancer
#18
H-Y Fan, D-M Duan, Y-F Liu
OBJECTIVE: To evaluate the value of three tumor markers serum Golgi phosphoprotein-3 (GOLPH3), cancer antigen 125 (CA125) and cancer antigen 19-9 (CA19.9) in the diagnosis and postoperative evaluation of ovarian cancer by detecting these three markers. PATIENTS AND METHODS: A total of 187 patients were studied and included in the ovarian cancer group, benign pelvic mass group, and the normal control group. The levels of serum Golgi phosphoprotein-3 (GOLPH3), cancer antigen 125 (CA125) and cancer antigen 199 (CA19...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29021083/fertility-preserving-surgery-for-advanced-stage-ovarian-germ-cell-tumors
#19
Dimitrios Nasioudis, Melissa K Frey, Eloise Chapman-Davis, Thomas A Caputo, Kevin Holcomb
OBJECTIVE: To evaluate the prevalence and safety of uterine preservation among premenopausal women diagnosed with a malignant ovarian germ-cell tumor (MOGCT) of advanced stage (stage II-IV). MATERIALS AND METHODS: The National Cancer Database was accessed and a cohort of women aged <40years, diagnosed with a MOGCT were identified. Those with stage II-IV disease who underwent cancer-directed surgery and received chemotherapy were selected for further analysis...
December 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28993225/treatment-approach-and-prognosis-of-pediatric-and-adolescent-nonepithelial-malignant-ovarian-tumors-a-retrospective-prognosis-analysis
#20
Peili Liang, Xin Zhang, Zhenfeng Zhang, Guocai Xu, Xingsu Yu, Sijin Li, Yuanyuan Zhang, Lijuan Bian, Bingzhong Zhang
STUDY OBJECTIVE: Nonepithelial malignant ovarian tumors are rare in the pediatric and adolescent population. The aim of this study was to observe the spectrum of pathology, presentation, outcome, and risk factors for survival of pediatric nonepithelial malignant ovarian tumors in a Chinese pediatric population. DESIGN, SETTING, PARTICIPANTS, INTERVENTIONS, AND MAIN OUTCOME MEASURES: This was a retrospective study of 171 girls (median age at presentation of 14 years) diagnosed with primary malignant ovarian tumors between 1990 and 2014 at the Yat-Sen Memorial Hospital and Cancer Center of Sun Yat-sen University...
October 6, 2017: Journal of Pediatric and Adolescent Gynecology
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