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https://www.readbyqxmd.com/read/17297442/conditional-activation-of-fgfr1-in-the-prostate-epithelium-induces-angiogenesis-with-concomitant-differential-regulation-of-ang-1-and-ang-2
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S F Winter, V D Acevedo, R D Gangula, K W Freeman, D M Spencer, N M Greenberg
The expression of fibroblast growth factor receptor (FGFR)-1 correlates with angiogenesis and is associated with prostate cancer (CaP) progression. To more precisely define the molecular mechanisms whereby FGFR1 causes angiogenesis in the prostate we exploited a transgenic mouse model, JOCK-1, in which activation of a conditional FGFR1 allele in the prostate epithelium caused rapid angiogenesis and progressive hyperplasia. By labeling the vasculature in vivo and applying a novel method to measure the vasculature in three dimensions, we were able to observe a significant increase in vascular volume 1 week after FGFR1 activation...
July 26, 2007: Oncogene
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