Soma Behera, Bandish Kapadia, Vasundhara Kain, Neeraja P Alamuru-Yellapragada, Vachana Murunikkara, Sireesh T Kumar, Phanithi Prakash Babu, Sriram Seshadri, Prasad Shivarudraiah, Jagadheshan Hiriyan, Narmadha Reddy Gangula, Subbareddy Maddika, Parimal Misra, Kishore V L Parsa
Nutritional abundance associated with chronic inflammation and dyslipidemia impairs the functioning of endoplasmic reticulum (ER) thereby hampering cellular responses to insulin. PHLPP1 was identified as a phosphatase which inactivates Akt, the master regulator of insulin mediated glucose homeostasis. Given the suggestive role of PHLPP1 phosphatase in terminating insulin signalling pathways, deeper insights into its functional role in inducing insulin resistance are warranted. Here, we show that PHLPP1 expression is enhanced in skeletal muscle of insulin resistant rodents which also displayed ER stress, an important mediator of insulin resistance...
May 2018: Biochimica et Biophysica Acta. Molecular Basis of Disease