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https://www.readbyqxmd.com/read/28098219/combined-lrrk2-mutation-aging-and-chronic-low-dose-oral-rotenone-as-a-model-of-parkinson-s-disease
#1
Hui-Fang Liu, Philip Wing-Lok Ho, Gideon Chi-Ting Leung, Colin Siu-Chi Lam, Shirley Yin-Yu Pang, Lingfei Li, Michelle Hiu-Wai Kung, David Boyer Ramsden, Shu-Leong Ho
Aging, genetics and environmental toxicity are important etiological factors in Parkinson's disease (PD). However, its pathogenesis remains unclear. A major obstacle is the lack of an appropriate experimental model which incorporates genetic susceptibility, aging and prolonged environmental toxicity. Here, we explored the interplay amongst these factors using mutant LRRK2(R1441G) (leucine-rich-repeat-kinase-2) knockin mice. We found that mutant primary cortical and mesencephalic dopaminergic neurons were more susceptible to rotenone-induced ATP deficiency and cell death...
January 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28096162/impact-of-extended-artesunate-duration-on-parasitological-outcome-in-a-cytocidal-murine-malaria-model
#2
Leah A Walker, David J Sullivan
Artemisinin-based combination therapies are a key pillar in global malaria control and are recommended as a first-line Plasmodium falciparum treatment. They rely upon a rapid, 4-log reduction in parasitemia by artemisinin compounds with a short half-life and the killing of remaining parasites by a partner compound with a longer half-life. Current treatment guidelines stipulate giving three 24 hour interval doses or six 12 hour interval doses over a 3-day period. Due to the short half-life of artesunate and artemether, almost all of the resulting cytocidal activity is confined within a single 48 hour asexual P...
January 17, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28090737/a-framework-for-how-environment-contributes-to-cancer-risk
#3
Michael E Hochberg, Robert J Noble
Evolutionary theory explains why metazoan species are largely protected against the negative fitness effects of cancers. Nevertheless, cancer is often observed at high incidence across a range of species. Although there are many challenges to quantifying cancer epidemiology and assessing its causes, we claim that most modern-day cancer in animals - and humans in particular - are due to environments deviating from central tendencies of distributions that have prevailed during cancer resistance evolution. Such novel environmental conditions may be natural and/or of anthropogenic origin, and may interface with cancer risk in numerous ways, broadly classifiable as those: increasing organism body size and/or life span, disrupting processes within the organism, and affecting germline...
January 16, 2017: Ecology Letters
https://www.readbyqxmd.com/read/28077803/gerosuppression-by-pan-mtor-inhibitors
#4
Olga V Leontieva, Mikhail V Blagosklonny
Rapamycin slows organismal aging and delays age-related diseases, extending lifespan in numerous species. In cells, rapamycin and other rapalogs such as everolimus suppress geroconversion from quiescence to senescence. Rapamycin inhibits some, but not all, activities of mTOR. Recently we and others demonstrated that pan-mTOR inhibitors, known also as dual mTORC1/C2 inhibitors, suppress senescent phenotype. As a continuation of these studies, here we investigated in detail a panel of pan-mTOR inhibitors, to determine their optimal gerosuppressive concentrations...
December 30, 2016: Aging
https://www.readbyqxmd.com/read/28074966/the-relationship-between-sun-exposure-and-all-cause-mortality
#5
Pelle G Lindqvist, Mona Landin-Olsson
We aimed to conduct a narrative review of the rapid advances in knowledge regarding sun exposure and all-cause mortality. Data support the hypothesis that sun exposure avoidance is a major risk factor for all-cause mortality in adjusted analysis (age, income, education, marital status, smoking, and comorbidity). This was caused by an increased risk of death due to cardiovascular disease (CVD) and noncancer/non-CVD. However, the increased life span among those with high sun exposure naturally results in an increased prevalence of cancer death...
January 11, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/28062841/metal-based-superoxide-dismutase-and-catalase-mimics-reduce-oxidative-stress-biomarkers-and-extend-life-span-of-saccharomyces-cerevisiae
#6
Thales de P Ribeiro, Fernanda L Fonseca, Mariana D C de Carvalho, Rodrigo M da C Godinho, Fernando Pereira de Almeida, Tatiana D Saint'Pierre, Nicolás A Rey, Christiane Fernandes, Adolfo Horn, Marcos D Pereira
Aging is a natural process characterized by several biological changes. In this context, oxidative stress appears as a key factor that leads cells and organisms to severe dysfunctions and diseases. To cope with reactive oxygen species and oxidative-related damage, there has been increased use of superoxide dismutase (SOD)/catalase (CAT) biomimetic compounds. Recently, we have shown that three metal-based compounds {[Fe(HPClNOL)Cl2]NO3, [Cu(HPClNOL)(CH3CN)](ClO4)2 and Mn(HPClNOL)(Cl)2}, harboring in vitro SOD and/or CAT activities, were critical for protection of yeast cells against oxidative stress...
January 15, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28062560/the-amyloid-phenomenon-and-its-links-with-human-disease
#7
Christopher M Dobson
The ability of normally soluble proteins to convert into amyloid fibrils is now recognized to be a generic phenomenon. The overall cross-β architecture of the core elements of such structures is closely similar for different amino acid sequences, as this architecture is dominated by interactions associated with the common polypeptide main chain. In contrast, the multiplicity of complex and intricate structures of the functional states of proteins is dictated by specific interactions involving the variable side chains, the sequence of which is unique to a given protein...
January 6, 2017: Cold Spring Harbor Perspectives in Biology
https://www.readbyqxmd.com/read/28058960/retrospective-reports-of-childhood-misfortune-are-associated-with-positive-and-negative-affect-in-adulthood
#8
Nicholas A Turiano, Nicole M Silva, Courtney McDonald, Patrick L Hill
Childhood misfortune refers to nonnormative experiences individuals encounter at younger ages that affect development across the life span. This study examined whether retrospectively reported childhood misfortune was associated with negative and positive affect in adulthood. In addition, we explored whether perceived control beliefs would moderate these associations. We used archival data from 6,067 adults ( Mage = 46.86; range = 20-75) from the Midlife Development in the United States study. Higher levels of misfortune were associated with higher levels of negative affect and lower levels of positive affect in adulthood...
January 1, 2017: International Journal of Aging & Human Development
https://www.readbyqxmd.com/read/28057201/the-consequences-of-self-reported-vision-change-in-later-life-evidence-from-the-english-longitudinal-study-of-ageing
#9
K Matthews, J Nazroo, J Whillans
OBJECTIVES: Using longitudinal data, we investigate whether deterioration and improvement in self-reported vision among people aged 50 years and older in England experience subsequent changes in various aspects of economic, psychological and social well-being. STUDY DESIGN: Longitudinal random effects modelling. METHODS: We used six waves of the biennial English Longitudinal Study of Ageing spanning 2002-2012. Self-reported vision change was classed as an increase or decrease in self-reported level of vision between each wave and effects on depression, satisfaction with life, quality of life, social engagement and equivalized income were examined...
January 2017: Public Health
https://www.readbyqxmd.com/read/28054804/developmental-delay-and-emotion-dysregulation-predicting-parent-child-conflict-across-early-to-middle-childhood
#10
Willa A Marquis, Amanda N Noroña, Bruce L Baker
Cumulative risk research has increased understanding of how multiple risk factors impact various socioemotional and interpersonal outcomes across the life span. However, little is known about risk factors for parent-child conflict early in development, where identifying predictors of change could be highly salient for intervention. Given their established association with parent-child conflict, child developmental delay (DD) and emotion dysregulation were examined as predictors of change in conflict across early to middle childhood (ages 3 to 7 years)...
January 5, 2017: Journal of Family Psychology: JFP
https://www.readbyqxmd.com/read/28052271/establishment-and-characterization-of-an-sv40-large-t-antigen-transduced-porcine-colonic-epithelial-cell-line
#11
Bastian Kaiser, Martina Böttner, Thilo Wedel, Ronald M Brunner, Tom Goldammer, Szilvia Lesko, Gotthold Gäbel, Alexander Gleich, Helga Pfannkuche
Continuous cell lines have become indispensable tools that have enabled investigations into cellular mechanisms by increasing experimental reproducibility and sample availability, and decreasing the use of experimental animals. To facilitate studies of epithelial barrier function of the porcine colon, we aimed to establish an epithelial cell line with an extended replicative capacity. Cells were isolated from the proximal colon of a 3-week-old piglet and transduced using a recombinant retroviral vector construct containing the simian virus 40 large T antigen (SV40 TAg)...
January 5, 2017: Cells, Tissues, Organs
https://www.readbyqxmd.com/read/28040262/environmental-impact-of-estrogens-on-human-animal-and-plant-life-a-critical-review
#12
REVIEW
Muhammad Adeel, Xiaoming Song, Yuanyuan Wang, Dennis Francis, Yuesuo Yang
BACKGROUND: Since the inception of global industrialization, steroidal estrogens have become an emerging and serious concern. Worldwide, steroid estrogens including estrone, estradiol and estriol, pose serious threats to soil, plants, water resources and humans. Indeed, estrogens have gained notable attention in recent years, due to their rapidly increasing concentrations in soil and water all over the world. Concern has been expressed regarding the entry of estrogens into the human food chain which in turn relates to how plants take up and metabolism estrogens...
December 28, 2016: Environment International
https://www.readbyqxmd.com/read/28035722/effects-of-nacl-stress-on-seed-germination-and-seedling-development-of-brassica-insularis-moris-brassicaceae
#13
Andrea Santo, Efisio Mattana, Luca Frigau, Antoni Marzo Pastor, Mari Carme Picher Morelló, Gianluigi Bacchetta
Brassica insularis is a protected plant that grows on both coastal and inland cliffs in the western Mediterranean Basin. The objective of this study was to test if any variability exists in the salt stress response during seed germination and seedling development in this species relative to its provenance habitat. Variability among three populations in the salt stress effects on the seed germination and its recovery under different temperatures was evaluated. The effect of nebulisation of a salt solution on seedling development was evaluated between populations growing to different distance from the sea...
December 30, 2016: Plant Biology
https://www.readbyqxmd.com/read/28035272/using-multiple-traits-to-assess-the-potential-of-introduced-and-native-vines-to-proliferate-in-a-tropical-region
#14
Diana L Delgado, Josimar Figueroa, Carla Restrepo
Predicting the invasive potential of introduced species remains an ongoing challenge due to the multiple interacting regional and global processes that facilitate the introduction and proliferation of alien species. This may be particularly true in regions where native species are increasingly reported as expanding and impacting ecosystems in ways indistinguishable from alien ones. Current approaches to assess the invasive potential of plants may be limited by the choice of traits used and the exclusion of native species...
December 2016: Ecology and Evolution
https://www.readbyqxmd.com/read/28028953/opinions-of-old-age-according-to-residents-of-polish-public-nursing-homes-and-members-of-the-universities-of-the-third-age
#15
Mateusz Cybulski, Elżbieta Krajewska-Kułak, Jacek Jamiołkowski
BACKGROUND: Statistical data from the turn of the 21st century shows a significant increase in the average human life span and, what follows, an extension of old age. OBJECTIVES: The aim of this study was to become familiar with the opinions submitted by respondents regarding aging and old age, health problems connected with aging and preferred health behaviors. MATERIAL AND METHODS: The research was conducted between January 3rd 2013 and February 15th 2014 on a group of 200 residents of public nursing homes and 200 members of the University of the Third Age using a questionnaire created by the authors...
September 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28028704/assessment-of-mercury-exposure-and-maternal-foetal-transfer-in-miniopterus-schreibersii-chiroptera-miniopteridae-from-southeastern-iberian-peninsula
#16
Fulgencio Lisón, Silvia Espín, Bárbara Aroca, José F Calvo, Antonio J García-Fernández
Mercury (Hg) is a highly toxic and widely distributed metal that is bioaccumulated in insectivorous mammals and may cause adverse effects on the reproductive system. Bats are considered excellent Hg bioindicators due to their wide distribution, life span, trophic position, metabolic rate and food intake. However, few studies have analysed Hg residues in bats, and to the best of our knowledge, no studies have been made in the Iberian Peninsula. The main aim of this study was to undertake the first ever assessment of Hg exposure in Schreiber's bent-winged bats inhabiting a natural cave in the southeast of Spain...
December 27, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28028170/influences-of-temperature-and-ootheca-age-on-the-life-history-of-the-cockroach-ootheca-parasitoid-aprostocetus-hagenowii-hymenoptera-eulophidae
#17
Hui-Siang Tee, Chow-Yang Lee
The influences of ootheca age and temperature on the life history of Aprostocetus hagenowii (Ratzeburg) (Hymenoptera: Eulophidae), a gregarious ootheca parasitoid of the American cockroach Periplaneta americana (L.) (Dictyoptera: Blattidae), were evaluated. Oothecae were incubated at 20, 25, and 30 °C to produce oothecae aged 1-60, 1-40, and 1-30 d old, respectively. Fitness traits (development time, percentage emergence, number of progeny, percentage female progeny, and female body size) of A. hagenowii developing in these different-aged oothecae were determined...
December 27, 2016: Journal of Economic Entomology
https://www.readbyqxmd.com/read/28025308/2-5-dimethyl-celecoxib-extends-drosophila-life-span-via-a-mechanism-that-requires-insulin-and-target-of-rapamycin-signaling
#18
Qi Wu, Ting Lian, Xiaolan Fan, Chaochun Song, Uma Gaur, Xueping Mao, Deying Yang, Matthew D W Piper, Mingyao Yang
The search for antiaging drugs is a key component of gerontology research. A few drugs with positive effects on life span in model organisms have been found. Here, we report that 2,5-dimethyl-celecoxib, a derivative of the anti-inflammatory drug celecoxib, can extend Drosophila life span and delay aging by a mechanism involving insulin signaling and target of rapamycin signaling. Importantly, its positive effects were apparent when the treatment window was restricted to the beginning of life or the later half...
December 26, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28017699/aging-rather-than-stress-strongly-influences-amino-acid-metabolisms-in-the-brain-and-genital-organs-of-female-mice
#19
Momoko Kodaira, Mao Nagasawa, Takeshi Yamaguchi, Hiromi Ikeda, Kimie Minaminaka, Vishwajit S Chowdhury, Shinobu Yasuo, Mitsuhiro Furuse
Aging and stress affect quality of life, and proper nourishment is one of means of preventing this effect. Today, there is a focus on the amount of protein consumed by elderly people; however, changes in the amino acid metabolism of individuals have not been fully considered. In addition, the difference between average life span and healthy life years is larger in females than it is in males. To prolong the healthy life years of females, in the present study we evaluated the influence of stress and aging on metabolism and emotional behavior by comparing young and middle-aged female mice...
December 23, 2016: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/28005423/cellular-senescence-and-lung-function-during-aging-yin-and-yang
#20
Judith Campisi
Cellular senescence is a cell fate decision and stress response that entails a permanent arrest of cell proliferation coupled to a complex secretory phenotype. Senescent cells increase in number with age in most, if not all, mammalian tissues, including the airways and lungs. They also increase at greater than expected numbers, compared with age-matched controls, at sites of age-related pathologies such as chronic obstructive pulmonary disorder and emphysema. The senescence response is a double-edged sword...
December 2016: Annals of the American Thoracic Society
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