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https://www.readbyqxmd.com/read/29467291/epigenetic-alterations-in-longevity-regulators-reduced-life-span-and-exacerbated-aging-related-pathology-in-old-father-offspring-mice
#1
Kan Xie, Devon P Ryan, Brandon L Pearson, Kristin S Henzel, Frauke Neff, Ramon O Vidal, Magali Hennion, Isabelle Lehmann, Melvin Schleif, Susanne Schröder, Thure Adler, Birgit Rathkolb, Jan Rozman, Anna-Lena Schütz, Cornelia Prehn, Michel E Mickael, Marco Weiergräber, Jerzy Adamski, Dirk H Busch, Gerhard Ehninger, Anna Matynia, Walker S Jackson, Eckhard Wolf, Helmut Fuchs, Valerie Gailus-Durner, Stefan Bonn, Martin Hrabě de Angelis, Dan Ehninger
Advanced age is not only a major risk factor for a range of disorders within an aging individual but may also enhance susceptibility for disease in the next generation. In humans, advanced paternal age has been associated with increased risk for a number of diseases. Experiments in rodent models have provided initial evidence that paternal age can influence behavioral traits in offspring animals, but the overall scope and extent of paternal age effects on health and disease across the life span remain underexplored...
February 21, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29463711/demographic-compensation-does-not-rescue-populations-at-a-trailing-range-edge
#2
Seema Nayan Sheth, Amy Lauren Angert
Species' geographic ranges and climatic niches are likely to be increasingly mismatched due to rapid climate change. If a species' range and niche are out of equilibrium, then population performance should decrease from high-latitude "leading" range edges, where populations are expanding into recently ameliorated habitats, to low-latitude "trailing" range edges, where populations are contracting from newly unsuitable areas. Demographic compensation is a phenomenon whereby declines in some vital rates are offset by increases in others across time or space...
February 20, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29462222/cross-sectional-survey-of-the-burden-of-illness-of-rosacea-by-erythema-severity
#3
Julie Harper, James Q Del Rosso, Ilia L Ferrusi
Rosacea is a chronic skin condition characterized by persistent central facial erythema. To explore the burden of illness of rosacea in US adults, a cross-sectional web-based survey was conducted. Participants answered questions on sociodemographics, clinical characteristics, bothersome symptoms, coping and avoidance behaviors, self-perceptions, and health care resource utilization, and completed 2 quality of life instruments, the 21-item rosacea-specific quality of life questionnaire (RosaQoL) and the 36-item Short Form Health Survey (SF-36)...
February 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29460453/severe-maternal-morbidity-due-to-sepsis-the-burden-and-preventability-of-disease-in-new-zealand
#4
Sam Lepine, Beverley Lawton, Stacie Geller, Peter Abels, Evelyn J MacDonald
BACKGROUND: Sepsis is a life-threatening systemic condition that appears to be increasing in the obstetric population. Clinical detection can be difficult and may result in increased morbidity via delays in the continuum of patient care. AIMS: To describe the burden of severe maternal morbidity (SMM) caused by sepsis in New Zealand and investigate the potential preventability. METHODS: A multidisciplinary expert review panel was established to review cases of obstetric sepsis admitted to intensive care or high-dependency units over an 18 month span in New Zealand...
February 20, 2018: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29457326/associations-between-adolescent-risk-for-restrictive-disordered-eating-and-long-term-outcomes-related-to-somatic-symptoms-body-mass-index-and-poor-well-being
#5
Evelina Landstedt, Anne Hammarström, A Kate Fairweather-Schmidt, Tracey Wade
OBJECTIVE: To date, no longitudinal, community-based studies have examined the association between disordered eating emerging in adolescence and long-term physical well-being. This study sought to explore the longitudinal associations between risk for restrictive disordered eating (DE-R; those not presenting with binge-purge symptoms) in adolescence and trajectories of functional somatic symptoms (FSS) and body mass index (BMI), and several indicators of poor physical well-being across early- to mid-adulthood, including medication, number of doctor visits, and sick leave...
February 18, 2018: British Journal of Health Psychology
https://www.readbyqxmd.com/read/29455275/the-effect-of-different-levels-of-dietary-restriction-on-glucose-homeostasis-and-metabolic-memory
#6
Stephanie Matyi, Jordan Jackson, Karla Garrett, Sathyaseelan S Deepa, Archana Unnikrishnan
Over the past 50 years, dietary restriction (DR) has been shown to extend the life span of a wide variety of organisms. A hallmark feature of DR is improved glucose homeostasis resulting in increased glucose tolerance and insulin sensitivity of animals ranging from rodents to humans. In this study, we demonstrate the early effects of varying levels of DR on glucose tolerance. Within 10 days of 40% DR, glucose tolerance was significantly improved and by 120 days; 10 and 20% DR also showed enhanced glucose tolerance...
February 17, 2018: GeroScience
https://www.readbyqxmd.com/read/29453937/trajectory-classes-of-cannabis-use-and-heavy-drinking-among-rural-african-american-adolescents-multilevel-predictors-of-class-membership
#7
Allen W Barton, Gene H Brody, Tamika C B Zapolski, Trenette C Goings, Steven M Kogan, Michael Windle, Tianyi Yu
AIMS: To inform research on the etiology and prevention of substance use among rural African American youth by (a) identifying developmental trajectory classes of cannabis use and heavy drinking across adolescence and young adulthood, and (b) examining associations between trajectory class membership and multi-level assessments of risk factors. DESIGN: A prospective study spanning nine years with assessments of cannabis use and heavy drinking, the catecholamines epinephrine and norepinephrine, perceived stress, and psychosocial risk factors...
February 17, 2018: Addiction
https://www.readbyqxmd.com/read/29452835/a-comparison-of-preoperative-and-intraoperative-vein-mapping-sizes-for-arteriovenous-fistula-creation
#8
Samuel H Hui, Ryan Folsom, Lois A Killewich, Joel E Michalek, Mark G Davies, Lori L Pounds
BACKGROUND: Duplex ultrasound (DUS) mapping of the veins and arteries of the upper extremity is a well-established practice in arteriovenous fistula creation for long-term hemodialysis access. Previous publications have shown that vein diameters varying from 2 to 3 mm are predictive of success. Regional anesthesia is known to result in vasodilation and thus to increase the diameter of upper extremity veins. This study compares the sizes of veins measured by preoperative DUS mapping with those obtained after regional anesthesia to determine whether intraoperative DUS results in increased vein diameters and thus changes in the operative plan...
February 13, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29452377/discordance-in-the-dependence-on-kisspeptin-signaling-in-mini-puberty-vs-adolescent-puberty-human-genetic-evidence
#9
Muhammad Shahab, Margaret Lippincott, Yee-Ming Chan, Addie Davies, Paulina M Merino, Lacey Plummer, Veronica Mericq, Stephanie Seminara
Context: Hypothalamic kisspeptin signaling plays a critical role in the initiation and maintenance of reproductive function. Biallelic mutations in the coding sequence of KISS1R (GPR54) have been identified in patients with idiopathic hypogonadotropic hypogonadism (IHH), but it is unknown whether biallelic variants can also be associated with related reproductive disorders. Case description: A missense homozygous variant (c.890G>T p.R297L) in KISS1R was identified in a child who presented with microphallus and bilateral cryptorchidism...
February 14, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29451957/outcome-of-childhood-anorexia-nervosa-the-results-of-a-five-to-ten-year-follow-up-study
#10
Beate Herpertz-Dahlmann, Astrid Dempfle, Karin Maria Egberts, Viola Kappel, Kerstin Konrad, Jennifer Anne Vloet, Katharina Bühren
OBJECTIVE: Although admissions of children with anorexia nervosa (AN) are increasing, there remains a dearth of up-to-date knowledge of the course and outcome of early-onset AN. The aim of the present study was to investigate the outcomes of patients with AN onset before the age of 14. METHOD: Sixty-eight consecutive former patients who met the DSM-IV criteria for AN and who had been treated at one of three German university hospitals were asked to participate in a follow-up study...
February 16, 2018: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/29451849/a-comprehensive-review-of-eggs-choline-and-lutein-on-cognition-across-the-life-span
#11
Taylor C Wallace
In 2030, one in five Americans will be older than 65 years, and with that an increase in the number of individuals who experience loss in cognitive capacity is to be expected. At the same time, nutrition within the first 1000 days postconception has been suggested to strongly influence cognitive outcomes across the life-span in humans. Eggs are a primary source of both choline and the xanthophyll carotenoid lutein in the western diet, and both have been suggested to influence cognitive function in humans. This comprehensive review critically examines the effects of eggs, choline, and lutein on cognition across the life-span...
February 16, 2018: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/29451489/-hiroshima-nagasaki-survivors-and-their-offspring-results-of-longterm-epidemiological-studies
#12
Bertrand Jordan
After the atomic bombing of Hiroshima and Nagasaki, long-term epidemiological studies were undertaken on the irradiated survivors and their offspring, and are still underway. These thorough studies involving tens of thousands of persons and published in hundreds of papers have shown a moderate increase in cancer incidence for irradiated survivors, with limited impact on their life span (loss of one year at most). In studies on the offspring of these survivors, no statistically significant deleterious effect on malformation frequency, incidence of mutations or mortality from cancer and other diseases has been seen so far...
February 2018: Médecine Sciences: M/S
https://www.readbyqxmd.com/read/29447902/the-erythrocyte-osmotic-resistance-test-as-screening-tool-for-cholesterol-related-lysosomal-storage-diseases
#13
Laura López de Frutos, Jorge J Cebolla, Pilar Irún, Ralf Köhler, Pilar Giraldo
BACKGROUND: Erythrocyte volume regulation and membrane elasticity are essential for adaptation to osmotic and mechanical stress, and life span. Here, we evaluated whether defective cholesterol trafficking caused by the rare lysosomal storages diseases (LSDs), Niemann-Pick type C (NPC) and Lysosomal acid lipase (LAL) deficiency (LALD) impairs these properties. Moreover, we tested whether measurements of cholesterol membrane content and osmotic resistance serve as a screening test for these LSDs...
February 12, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29446968/aging-and-altruism-in-intertemporal-choice
#14
Erika P Sparrow, Julia Spaniol
In addition to making decisions about gains and losses that affect only ourselves, we often make decisions that affect others. Research on life span changes in motivation suggests that altruistic motives become stronger with age, but no prior research has examined how altruism affects tolerance for temporal delays. Experiment 1 used a realistic financial decision making task involving choices for gains, losses, and donations. Each decision required an intertemporal choice between a smaller-immediate and a larger-later option...
February 15, 2018: Psychology and Aging
https://www.readbyqxmd.com/read/29446064/roles-of-community-pharmacists-in-improving-oral-health-awareness-in-plateau-state-northern-nigeria
#15
Olaniyi Olufemi Taiwo, Raymond Panas
INTRODUCTION: There is poor oral health awareness in Nigeria because of limited access to correct information on oral health as well as a lack of oral health-care providers. The purpose of this study was to describe the roles of community pharmacists (CPs) in Plateau State, Northern Nigeria, as sources of oral health information in their communities. METHODS: A quantitative cross-sectional study on CPs spanning the entire State. Data collection was a survey method using a structured paper-based self-administered questionnaire...
February 15, 2018: International Dental Journal
https://www.readbyqxmd.com/read/29444657/understanding-the-rapid-increase-in-life-expectancy-in-shanghai-china-a-population-based-retrospective-analysis
#16
Hanyi Chen, Lipeng Hao, Chen Yang, Bei Yan, Qiao Sun, Lianghong Sun, Hua Chen, Yichen Chen
BACKGROUND: Life expectancy at birth (LE) is a comprehensive measure that accounts for age-specific death rates in a population. Shanghai has ranked first in LE in China mainland for decades. Understanding the reasons behind its sustained gain in LE provides a good reflection of many other cities in China. The aim of this study is intended to explore temporal trend in age- and cause-specific gains in LE in Shanghai and the probable reasons lay behind. METHODS: Joinpoint regression was applied to evaluate temporal trend in LE and the long time span was then divided accordingly...
February 14, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29441466/hyaluronic-acid-grafted-plga-nanoparticles-for-the-sustained-delivery-of-berberine-chloride-for-an-efficient-suppression-of-ehrlich-ascites-tumors
#17
Priyanka Bhatnagar, Manisha Kumari, Richa Pahuja, A B Pant, Y Shukla, Pradeep Kumar, K C Gupta
To promote the specific targeting and elimination of CD44-positive cancer cells, berberine chloride (BRB)-encapsulated hyaluronic acid-grafted poly(lactic-co-glycolic acid) copolymer (BRB-d(HA)-g-PLGA) nanoparticles (NPs) were prepared. The targeted action of these NPs was compared to non-targeted BRB-loaded PLGA NPs and bulk BRB. The in vitro studies demonstrated faster release of BRB and increased cytotoxicity of BRB-d(HA)-g-PLGA NPs in Hela and MCF-7 cells in comparison to BRB-PLGA NPs and bulk BRB. The uptake of BRB-d(HA)-g-PLGA NPs was increased in case of MCF-7 cells as compared to HeLa cells owing to the higher expression of CD44 receptors on MCF-7 cells...
February 13, 2018: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29441364/impaired-cohesion-and-homologous-recombination-during-replicative-aging-in-budding-yeast
#18
Sangita Pal, Spike D Postnikoff, Myrriah Chavez, Jessica K Tyler
The causal relationship between genomic instability and replicative aging is unclear. We reveal here that genomic instability at the budding yeast ribosomal DNA (rDNA) locus increases during aging, potentially due to the reduced cohesion that we uncovered during aging caused by the reduced abundance of multiple cohesin subunits, promoting increased global chromosomal instability. In agreement, cohesion is lost during aging at other chromosomal locations in addition to the rDNA, including centromeres. The genomic instability in old cells is exacerbated by a defect in DNA double-strand break (DSB) repair that we uncovered in old yeast...
February 2018: Science Advances
https://www.readbyqxmd.com/read/29440697/ectopic-expression-of-s28a-mutated-histone-h3-modulates-longevity-stress-resistance-and-cardiac-function-in-drosophila
#19
J P Joos, A R Saadatmand, C Schnabel, I Viktorinová, T Brand, M Kramer, S Nattel, D Dobrev, P Tomancak, J Backs, P Kleinbongard, G Heusch, K Lorenz, E Koch, S Weber, A El-Armouche
Histone H3 serine 28 (H3S28) phosphorylation and de-repression of polycomb repressive complex (PRC)-mediated gene regulation is linked to stress conditions in mitotic and post-mitotic cells. To better understand the role of H3S28 phosphorylation in vivo, we studied a Drosophila strain with ectopic expression of constitutively-activated H3S28A, which prevents PRC2 binding at H3S28, thus mimicking H3S28 phosphorylation. H3S28A mutants showed prolonged life span and improved resistance against starvation and paraquat-induced oxidative stress...
February 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29437183/ask-the-right-questions-what-do-non-caregiving-adult-children-need-from-health-care-providers
#20
Munira Wells, Connie Kartoz
Extended healthy life spans are a relatively recent phenomenon that increase the amount of time families spend with older adults in non-caregiving roles. As the emphasis of health care moves to population health and health prevention, nurses caring for older adults must be knowledgeable about this family life stage. To learn more about the lived experience of non-caregiving adult children, 16 non-caregiving adult children were interviewed. The purpose of the current article is to share what needs non-caregiving adult children have from the health care system as they obtain care for themselves and accompany their parent for health care visits...
February 13, 2018: Journal of Gerontological Nursing
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