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Wilson's Disease in Native American's

Natasha N Gaudreault, Sabarish V Indran, P K Bryant, Juergen A Richt, William C Wilson
Rift Valley fever virus (RVFV) causes disease outbreaks across Africa and the Arabian Peninsula, resulting in high morbidity and mortality among young domestic livestock, frequent abortions in pregnant animals, and potentially severe or fatal disease in humans. The possibility of RVFV spreading to the United States or other countries worldwide is of significant concern to animal and public health, livestock production, and trade. The mechanism for persistence of RVFV during inter-epidemic periods may be through mosquito transovarial transmission and/or by means of a wildlife reservoir...
2015: Frontiers in Microbiology
Larissa A Nituch, Jeff Bowman, Paul J Wilson, Albrecht I Schulte-Hostedde
Aleutian mink disease virus (AMDV) causes a parvovirus infection, initially characterized in American mink (Neovison vison), that may have harmful effects on wild populations of susceptible animals. In North America, where American mink are native, the origin, host range, and prevalence of AMDV in wild species is not clear. We studied striped skunks (Mephitis mephitis) and raccoons (Procyon lotor) to determine whether species sympatric with mink are potential reservoirs in the transmission of AMDV to wild mink and mink farms...
April 2015: Journal of Wildlife Diseases
Jim P Stimpson, Fernando A Wilson, Dejun Su
Unauthorized immigrants and other immigrants who have been in the United States for less than five years have few options for accessing health care through public programs. In light of the ongoing national debate about immigration reform and the impact of the Affordable Care Act on immigrants, we examined differences in health care spending by nativity and legal status using Medical Expenditure Panel Survey data for the period 2000-09. We found that unauthorized, legal, and naturalized immigrants together accounted for $96...
July 2013: Health Affairs
Eric J Horstick, Jeremy W Linsley, James J Dowling, Michael A Hauser, Kristin K McDonald, Allison Ashley-Koch, Louis Saint-Amant, Akhila Satish, Wilson W Cui, Weibin Zhou, Shawn M Sprague, Demetra S Stamm, Cynthia M Powell, Marcy C Speer, Clara Franzini-Armstrong, Hiromi Hirata, John Y Kuwada
Excitation-contraction coupling, the process that regulates contractions by skeletal muscles, transduces changes in membrane voltage by activating release of Ca(2+) from internal stores to initiate muscle contraction. Defects in excitation-contraction coupling are associated with muscle diseases. Here we identify Stac3 as a novel component of the excitation-contraction coupling machinery. Using a zebrafish genetic screen, we generate a locomotor mutation that is mapped to stac3. We provide electrophysiological, Ca(2+) imaging, immunocytochemical and biochemical evidence that Stac3 participates in excitation-contraction coupling in muscles...
2013: Nature Communications
Ahva Shahabi, Melissa L Wilson, Juan Pablo Lewinger, T Murphy Goodwin, Mariana C Stern, Sue A Ingles
BACKGROUND: Latinos are a heterogeneous population in terms of demographics, culture, and genetic admixture from three racial groups (white, African, and Native American). This study examines the role of genetic ancestry and environmental risk factors in the risk of hypertensive disorder of pregnancy among Latinas in Los Angeles County. METHODS: Gestational hypertension, preeclampsia, eclampsia, or hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome cases (n = 125), plus unaffected controls (n = 161), were recruited from Los Angeles County + University of Southern California Women's and Children's Hospital from 1999 through 2008...
March 2013: Epidemiology
Lynn D Wilson, Ginette A Hinds, James B Yu
UNLABELLED: The T- and B-cell cutaneous lymphomas (CLs) are relatively rare, and information regarding clinical presentation and differences among racial groups might be helpful in determining the best course of clinical care. Data from nearly 5000 patients with CL from the SEER (Surveillance, Epidemiology and End Results Program) registry were evaluated. Nonwhite racial groups present with mycosis fungoides (MF) at an earlier age compared with white, and African American (AA) have increased risk of presenting with higher T-stage compared with white patients...
October 2012: Clinical Lymphoma, Myeloma & Leukemia
Jennifer J Salinas, Bassent Abdelbary, Jeffrey Wilson, Monir Hossain, Susan Fisher-Hoch, Joseph McCormick
BACKGROUND: This study uses the Framingham Risk Score (FRS) for 10-year cardiovascular disease (CVD) to evaluate differences between Mexican American immigrants and the U.S.-born population. METHODS AND RESULTS: Data from the Cameron County Hispanic Cohort (N=1,559). Average total risk scores were generated by age group for each gender. Regression analysis was conducted adjusting for covariates and interaction effects. Both women and men in the CCHC sample who were long-term immigrant residents (mean FRS scores women 4...
May 2012: Journal of Health Care for the Poor and Underserved
Mihriye Mete, Charlton Wilson, Elisa T Lee, Angela Silverman, Marie Russell, Mario Stylianou, Jason G Umans, Wenyu Wang, Wm J Howard, Robert E Ratner, Barbara V Howard, Jerome L Fleg
OBJECTIVES: Cardiovascular disease prevention for patients with type 2 diabetes is accomplished through hypertension and dyslipidemia management. Although studies have established strategies for lowering low-density lipoprotein cholesterol (LDL-C) and blood pressure (BP), none have examined whether glycemia influences ability to achieve lipid and BP targets. This post hoc analysis from the Stop Atherosclerosis in Native Diabetics Study examines the role of baseline glycemia in achieving standard and aggressive targets and outcomes after 36 months...
November 2011: Journal of Diabetes and its Complications
Mirna Kirin, Ruth McQuillan, Christopher S Franklin, Harry Campbell, Paul M McKeigue, James F Wilson
The human genome is characterised by many runs of homozygous genotypes, where identical haplotypes were inherited from each parent. The length of each run is determined partly by the number of generations since the common ancestor: offspring of cousin marriages have long runs of homozygosity (ROH), while the numerous shorter tracts relate to shared ancestry tens and hundreds of generations ago. Human populations have experienced a wide range of demographic histories and hold diverse cultural attitudes to consanguinity...
2010: PloS One
Elizabeth D Ferucci, Katherine J Donnithorne, Kathryn R Koller, Amy Swango-Wilson, Jacqueline Pflaum, Anne P Lanier
OBJECTIVE: Rheumatoid arthritis (RA) is highly prevalent in some Alaska Native and American Indian populations. Quality indicators for RA have been proposed, but these have not been widely implemented or used to assess RA care in Alaska Native or American Indian populations. METHODS: Medical records were included if they met the following criteria: RA diagnosed before October 2000 fulfilling American College of Rheumatology classification criteria; all care for RA at the Alaska Native Medical Center...
October 2010: Quality & Safety in Health Care
R Daniela Dávila, Colleen G Julian, Megan J Wilson, Vaughn A Browne, Carmelo Rodriguez, Abigail W Bigham, Mark D Shriver, Enrique Vargas, Lorna G Moore
OBJECTIVE: This prospective study was designed to determine whether variation in angiogenic (placental growth factor [PlGF]) and/or anti-angiogenic (soluble fms-like tyrosine kinase [sFlt-1]) factors contribute to the protective effect of highland ancestry (Andean) from altitude-associated reductions in fetal growth. STUDY DESIGN: Plasma sFlt-1 and PlGF levels, uterine artery (UA) blood flow, and fetal biometry were determined in low-altitude (400 m; Andean n = 27, European n = 28) and high-altitude (3600 m; Andean n = 51, European n = 44) residents during pregnancy (20 and 36 weeks) and 4 months postpartum...
September 2010: Reproductive Sciences
Charlton Wilson, Chun-Chih Huang, Nawar Shara, Barbara V Howard, Jerome L Fleg, Jeffrey A Henderson, Wm James Howard, Heather Huentelman, Elisa T Lee, Mihriye Mete, Marie Russell, James M Galloway, Angela Silverman, Mario Stylianou, Jason Umans, Matthew R Weir, Fawn Yeh, Robert E Ratner
BACKGROUND: The Stop Atherosclerosis in Native Diabetics Study (SANDS) reported cardiovascular benefit of aggressive versus standard treatment targets for both low-density lipoprotein cholesterol (LDL-C) and blood pressure (BP) in diabetic individuals. OBJECTIVE: In this analysis, we examined within trial cost-effectiveness of aggressive targets of LDL-C ≤70 mg/dL and systolic BP ≤115 mmHg versus standard targets of LDL-C ≤100 mg/dL and systolic BP ≤130 mmHg...
May 2010: Journal of Clinical Lipidology
Curtis W Noonan, Blakely D Brown, Bonnie Bentley, Kathrene Conway, Mary Corcoran, Kris FourStar, Priscilla Freide, Bethany Hemlock, Sharon Wagner, Todd Wilson
OBJECTIVE: There are sparse data on the variability in childhood asthma across different Native American communities and the corresponding associations with known risk factors such as high body mass index and family history. The purpose of this study is to evaluate cross-sectional data on childhood asthma prevalence, body mass index, and other descriptive variables among Native Americans in five rural Northern Plains Indian reservation communities. METHODS: A school-based screening program was conducted on four Northern Plains Indian Reservations...
June 2010: Journal of Asthma: Official Journal of the Association for the Care of Asthma
Rudiney Ringenberg, João R S Lopes, Marcos Botton, Wilson S De Azevedo-Filho, Rodney R Cavichioli
In some American countries, grapevines are affected by Pierce's disease (PD), which is caused by a particular strain of Xylella fastidiosa not yet reported in Brazil. In order to investigate the potential for PD spread in Brazil in case of pathogen introduction, we conducted a faunistic analysis of leafhoppers (Hemiptera: Cicadellidae) associated to vineyards in the State of Rio Grande do Sul, with emphasis in the subfamily Cicadellinae (sharpshooters), which includes the main potential vectors of X. fastidiosa...
March 2010: Neotropical Entomology
Joan O'Connell, Rong Yi, Charlton Wilson, Spero M Manson, Kelly J Acton
OBJECTIVE: American Indians and Alaska Natives are 2.3 times more likely to have diabetes than are individuals in the U.S. general population. The objective of this study was to compare morbidity among American Indian and U.S. adults with diabetes. RESEARCH DESIGN AND METHODS: We extracted demographic and health service utilization data for an adult American Indian population aged 18-64 years (n = 30,121) served by the Phoenix Service Unit from the Indian Health Service clinical reporting system...
July 2010: Diabetes Care
Susan A Sabatino, Sherri L Stewart, Reda J Wilson
OBJECTIVE: We examined racial/ethnic variations in uterine corpus cancer incidence. METHODS: Data are from state cancer registries meeting quality criteria in the National Program of Cancer Registries (NPCR) and Surveillance, Epidemiology, and End Results (SEER) programs, 2001-2003. We included females with microscopically confirmed invasive uterine corpus cancer (n = 97,098). We calculated age-adjusted incidence rates per 100,000, stratified by race and ethnicity...
March 2009: Journal of Women's Health
Stephanie R Bialek, John T Redd, Audrey Lynch, Tara Vogt, Sharon Lewis, Charlton Wilson, Beth P Bell
GOALS: To determine the etiologies of chronic liver disease among American Indians. BACKGROUND: American Indians are disproportionately affected by chronic liver disease, yet little is known about its underlying etiologies in this group. STUDY: We conducted a cross-sectional prevalence study at medical centers serving American Indian populations in Arizona and California. Patients' records were reviewed to identify those with chronic liver disease (ICD-9 code for chronic liver disease or 2 abnormal liver tests > or = 6 mo apart)...
August 2008: Journal of Clinical Gastroenterology
J Enrique Herrera-Galeano, Diane M Becker, Alexander F Wilson, Lisa R Yanek, Paul Bray, Dhananjay Vaidya, Nauder Faraday, Lewis C Becker
OBJECTIVE: Platelet endothelial aggregation receptor-1 (PEAR1) is a recently identified platelet transmembrane protein that becomes activated by platelet contact. We looked for novel genetic variants in PEAR1 and studied their association with agonist-induced native platelet aggregation and with the inhibitory effect of aspirin on platelets. METHODS AND RESULTS: We genotyped PEAR1 for 10 single nucleotide polymorphisms (SNPs), selected for optimal gene coverage at a density of 4 kb, in 1486 apparently healthy individuals from two generations of families with premature CAD...
August 2008: Arteriosclerosis, Thrombosis, and Vascular Biology
Suzan Murphy, Charlton Wilson
Type 2 diabetes is a serious, costly, and increasingly common disease among Native American communities. Increasing evidence suggests that early infant nutrition, particularly breastfeeding, may have a significant impact on the development of diabetes in later life. In this report, the authors describe the scientific basis and development of an innovative program that targets promotion of breastfeeding among Native women as a type 2 diabetes prevention intervention. The program materials, evaluation methods, and outcomes are presented...
May 2008: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
Roger P Pickering, Bridget F Grant, S Patricia Chou, Wilson M Compton
OBJECTIVE: This study examined associations of overweight, obesity, and extreme obesity with sociodemographic characteristics and specific DSM-IV Axis I and II disorders among men and women. METHOD: Face-to-face interviews were conducted in a large national survey of the adult U.S. population conducted from 2001 to 2002. RESULTS: In general, black men; black, Hispanic, and Native American women; women who were not married/cohabiting; and those residing in the South and Midwest and in rural areas were at greatest risk of overweight, obesity, and extreme obesity...
July 2007: Journal of Clinical Psychiatry
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