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Folic acid defencity

María J M Alférez, Emilio Rivas, Javier Díaz-Castro, Silvia Hijano, Teresa Nestares, Miguel Moreno, Margarita S Campos, Jose A Serrano-Reina, Inmaculada López-Aliaga
The aim of the current study was to asses the effect of goat or cow milk-based diets, either normal or Fe-overloaded and folic acid supplement on some aspects of hepatic physiology, enzymatic antioxidant defence and lipid peroxidation in liver, brain and erythrocyte of control and anaemic rats after chronic Fe repletion. 160 male Wistar rats were placed on 40 d in two groups, a control group receiving normal-Fe diet and the Fe-deficient group receiving low Fe diet. Lately, the rats were fed with goat and cow milk-based diets during 30 d, with normal-Fe content or Fe-overload and either with normal folic or folic acid supplemented...
February 2015: Journal of Dairy Research
Tatiana Barichello, Jaqueline S Generoso, Lutiana R Simões, Amanda V Steckert, Ana Paula Moreira, Diogo Dominguini, Pâmela Ferrari, Carolina Gubert, Flávio Kapczinski, Luciano K Jornada, Lucineia G Danielski, Fabricia Petronilho, Josiane Budni, João Quevedo
Streptococcus pneumoniae is a common cause of bacterial meningitis, with a high mortality rate and neurological sequelae. In contrast, folic acid plays an important role in neuroplasticity and the preservation of neuronal integrity. In the present study, we evaluated the influence of folic acid on memory, oxidative damage, enzymatic defence, and brain-derived neurotrophic factor (BDNF) expression in experimental pneumococcal meningitis. In animals that received folic acid at a dose of 10 or 50 mg, there was a reduction in both crossing and rearing during an open-field task compared with the training session, demonstrating habituation memory...
May 2015: Journal of Neural Transmission
Jing Fan, Jiangbin Ye, Jurre J Kamphorst, Tomer Shlomi, Craig B Thompson, Joshua D Rabinowitz
ATP is the dominant energy source in animals for mechanical and electrical work (for example, muscle contraction or neuronal firing). For chemical work, there is an equally important role for NADPH, which powers redox defence and reductive biosynthesis. The most direct route to produce NADPH from glucose is the oxidative pentose phosphate pathway, with malic enzyme sometimes also important. Although the relative contribution of glycolysis and oxidative phosphorylation to ATP production has been extensively analysed, similar analysis of NADPH metabolism has been lacking...
June 12, 2014: Nature
M Petras, Z Tatarkova, M Kovalska, D Mokra, D Dobrota, J Lehotsky, A Drgova
Elevated concentration of the homocysteine (Hcy) in human tissues, resulting either from mutations in genes enconding Hcy-metabolizing enzymes, or from deficiences of folic acid has recognized cytotoxic effect. Even a mild Hcy level increase is a risk factor for cardiovascular diseases and stroke in humans and also a risk factor for neurodegenerative disordes, such as dementia, or Alzheimer's disease. However, it is not yet clear whether homocysteine is a marker, or a causative agent. We present here an overview of recent data on the homocysteine metabolism and on the genetic and the metabolic causes of hyperhomocysteinemia-related pathologies in humans...
February 2014: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
Chih-Chien Sung, Yu-Chuan Hsu, Chun-Chi Chen, Yuh-Feng Lin, Chia-Chao Wu
Patients with chronic kidney disease (CKD) have high cardiovascular mortality and morbidity and a high risk for developing malignancy. Excessive oxidative stress is thought to play a major role in elevating these risks by increasing oxidative nucleic acid damage. Oxidative stress results from an imbalance between reactive oxygen/nitrogen species (RONS) production and antioxidant defense mechanisms and can cause vascular and tissue injuries as well as nucleic acid damage in CKD patients. The increased production of RONS, impaired nonenzymatic or enzymatic antioxidant defense mechanisms, and other risk factors including gene polymorphisms, uremic toxins (indoxyl sulfate), deficiency of arylesterase/paraoxonase, hyperhomocysteinemia, dialysis-associated membrane bioincompatibility, and endotoxin in patients with CKD can inhibit normal cell function by damaging cell lipids, arachidonic acid derivatives, carbohydrates, proteins, amino acids, and nucleic acids...
2013: Oxidative Medicine and Cellular Longevity
S N Nematollahi-Mahani, G H Azizollahi, M R Baneshi, Z Safari, S Azizollahi
Varicocele is among the most common problems which may lead to male infertility. Spermatogenesis is impaired as a consequence of this vascular defect, through mechanisms that are not well described. This study aimed to evaluate serum hormonal level (inhibin B, FSH and testosterone) and seminal plasma antioxidant defence levels after folic acid and zinc sulphate administration in varicocelectomised patients. Participants were randomly allocated to four experimental groups. Our randomisation schedule was as follows: zinc sulphate/folic acid, folic acid, zinc sulphate and placebo...
April 2014: Andrologia
Christopher A Maloney, Susan M Hay, Martin D Reid, Gary Duncan, Fergus Nicol, Kevin D Sinclair, William D Rees
A methyl-deficient diet (MD) lacking folic acid and the associated methyl donors choline and methionine, fed to the laboratory rat during the periods of oocyte and embryo development, has been shown to programme glucose metabolism in the offspring. The hepatic proteome of the male offspring of female rats fed MD diets for 3 weeks prior to mating and for the first 5 days of gestation has been examined by 2-dimensional gel electrophoresis. Three groups of differentially abundant proteins associated with energy metabolism, amino acid metabolism and antioxidant defence were identified in the soluble proteins extracted from the liver from the MD offspring at both 6 and 12 months of age...
March 2013: Genes & Nutrition
Patrizia Riso, Antonella Brusamolino, Massimo Moro, Marisa Porrini
Cruciferous vegetables are characterized by high amounts of glucosinolates (GLSs) that are hydrolysed to isothiocyanates (ITCs) and other phytochemicals. The aim of the study was to verify the effect of broccoli intake on plasma levels of carotenoids, vitamins and ITCs and on glutathione S-transferase (GST) activity. Twenty healthy subjects, characterized for GSTM1 and GSTT1 genotype, participated in a cross-over intervention study (broccoli diet versus cruciferous-free diet). Subjects consumed a daily portion of broccoli (10 days, 200 g) providing glucosinolates (200 micromol non-indolyl ITCs evaluated by cyclocondensation reaction after myrosinase treatment), vitamin C (about 100 mg) and carotenoids (about 5 mg lutein and beta-carotene)...
2009: International Journal of Food Sciences and Nutrition
P Christian, G L Darmstadt, L Wu, S K Khatry, S C Leclerq, J Katz, K P West, R K Adhikari
OBJECTIVE: Micronutrient deficiencies during pregnancy may be linked to poor newborn health and poor host defences against infection. We assessed newborn morbidity to determine the effect of four combinations of antenatal micronutrient supplements. DESIGN: Cluster-randomised, double-masked, controlled trial. SETTING: Rural community in Nepal. INTERVENTIONS: Women received daily supplements from early pregnancy through to 3 months postpartum of vitamin A alone (control) or vitamin A with folic acid, folic acid plus iron, folic acid plus iron plus zinc or a multiple micronutrient supplement containing these and 11 other nutrients...
August 2008: Archives of Disease in Childhood
Silvia Maggini, Eva S Wintergerst, Stephen Beveridge, Dietrich H Hornig
Adequate intakes of micronutrients are required for the immune system to function efficiently. Micronutrient deficiency suppresses immunity by affecting innate, T cell mediated and adaptive antibody responses, leading to dysregulation of the balanced host response. This situation increases susceptibility to infections, with increased morbidity and mortality. In turn, infections aggravate micronutrient deficiencies by reducing nutrient intake, increasing losses, and interfering with utilization by altering metabolic pathways...
October 2007: British Journal of Nutrition
Anna Blázovics, Eva Sárdi, Klára Szentmihályi, L Váli, Mária Takács-Hájos, Eva Stefanovits-Bányai
Redox homeostasis can be considered as the cumulative action of all free radical reactions and antioxidant defences in different tissues, which provide suitable conditions for life. Transition metal ions are ubiquitous in biological systems. Beta vulgaris var. rubra (table beet root) contains several bioactive agents (e.g. betain, betanin, vulgaxanthine, polyphenols, folic acid) and different metal elements (e.g. Al, B, Ba, Ca, Cu, Fe, K, Mg, Mn, Na, Zn), which act on the various physiological routes. Therefore we studied the effect of this metal rich vegetable on element content of the liver in healthy rats...
September 2007: Acta Biologica Hungarica
Christopher J McNeil, Susan M Hay, Garry J Rucklidge, Martin Reid, Gary Duncan, Christopher A Maloney, William D Rees
The importance of folic acid and the methionine cycle in fetal development is well recognised even though the mechanism has not been established. Since the cycle is active in the maternal liver, poor folate status may modify hepatic metabolism. Pregnant rats were fed diets deficient in folic acid (-F) or in three key methyl donors, folic acid, choline and methionine (-FLMLC) and the maternal liver was analysed on day 21 of gestation. Two-dimensional gel electrophoresis of soluble proteins identified differentially abundant proteins, which could be allocated into nine functional groups...
February 2008: British Journal of Nutrition
Jacques Daniel
Using the fitness-based interferential genetics (FIG) approach in yeast, potential in vivo gene targets of the Rpd3 histone deacetylase were selected. In agreement with previous studies using different methods, three genes were found to be involved in the translational machinery (MRPL27, FHL1 and RDN1). Moreover, other selected genes are linked to cell-cycle control (CSE4, AMN1, VAC17 and GRR1). In addition to playing a crucial role in cell cycle progression to the S phase and participating in the G(2)-M transition, GRR1 has important functions related to nutrient import to the cell via the the derepression of hexose transporters and the induction of amino acid permeases...
July 2007: Yeast
Alena Kazimírová, Magdaléna Barancoková, Marica Krajcovicová-Kudlácková, Katarína Volkovová, Marta Staruchová, Martina Valachovicová, Viera Pauková, Pavel Blazícek, Ladislava Wsólová, Mária Dusinská
A vegetarian diet results in higher intake of vitamins and micronutrients, which - although providing antioxidant defence - may lead to deficiency in other micronutrients involved in DNA metabolism and stability (such as vitamins belonging to the B group). The principal difference among various vegetarian diets is the extent to which animal products are avoided. We have performed a pilot study to determine the relationship between the micronucleus frequency in lymphocytes and diet, and we compared the levels of Vitamins C and E, beta-carotene, B(12), folic acid, homocysteine and total antioxidant capacity in healthy vegetarians and non-vegetarians...
December 10, 2006: Mutation Research
Katharina Schroecksnadel, Barbara Frick, Christiana Winkler, Dietmar Fuchs
Inflammation and immune activation are crucially involved in the pathogenesis of atherosclerosis and cardiovascular disease. Accordingly, markers of inflammation such as fibrinogen, ferritin, C-reactive protein or neopterin are found in patients with vascular diseases, correlating strongly with the extent of disease and predicting disease progression. Neopterin formation by human monocyte-derived macrophages and dendritic cells is induced by the pro-inflammatory cytokine interferon-gamma, which is released by activated T-lymphocytes...
July 2006: Current Vascular Pharmacology
Sameer Otoom, Moiz Bakhiet, Abdulmajeed Khan, Reginald Sequeira
PURPOSE: Previous studies showed an association between the blood levels of folate and vitamin B(12) and the risk for cardiovascular disease. The aim of this study is to investigate the effect of chronic use of phenytoin, carbamazepine or valproate monotherapy on the plasma levels of folate and B(12), and to compare folate and B(12) levels in epileptic patients with or without cardiovasular disorders. METHODS: The study was conducted in the outpatient neurology clinic at Bahrain Defence Force (BDF) Hospital between January-July, 2005...
February 2006: Neuro Endocrinology Letters
Nathalie Le Floch, Catherine Jondreville, Jacques J Matte, Bernard Seve
Deterioration of sanitary conditions in piggeries is known to limit growth performance through inducing a moderate immune response. This article reports the results of an experiment performed to reproduce the consequences of bad sanitary conditions on growth performance and nutrient plasma concentrations of piglets after weaning. We propose to use these experimental conditions as a model for studying the interactions between nutrition and pig health. In this experiment, 20 pairs of littermate piglets were selected and weaned at 28 days of age on the basis of their body weight...
February 2006: Archives of Animal Nutrition
Simona Storti, Alfredo Giuseppe Cerillo, Antonio Rizza, Isabella Giannelli, Giuliana Fontani, Mattia Glauber, Aldo Clerico
OBJECTIVE: It has been suggested that cardiac surgery-related ischemia-reperfusion injury to the myocardium is caused by the oxidative stress, derived from the formation of reactive oxygen species in the early phases of the reperfusion. The availability of cysteine, mostly deriving from homocysteine (Hcy) via the trans-sulfuration pathway, is determinant for the synthesis of glutathione (GSH), which in turn acts as a first line of defence against oxidative stress. Indeed, an increased consumption of Hcy in response to oxidative stress has been described...
October 2004: European Journal of Cardio-thoracic Surgery
C K Booth
Background - Defence food technology aims to provide an easy-to-prepare and palatable, nutritionally complete combat ration pack (CRP) which has minimal weight and volume and maximum shelf life under all climatic extremes. The nutritional aims are to identify the optimal nutrient mix to sustain the soldier in the face of operational stressors such as fatigue, intense physical activity, extreme climate and negative psychological factors and to encourage consumption. Review - Two studies of CRP consumption, which differed in duration and design, were conducted recently by DSTO Scottsdale...
2003: Asia Pacific Journal of Clinical Nutrition
C J Ashworth, C Antipatis
Vitamins and minerals serve essential roles in cellular metabolism, maintenance and growth throughout life. They are also central components of many enzymes and transcription factors. However, the need for optimum amounts of key micronutrients at critical stages during the periovulatory period and subsequent embryonic and fetal life has become the focus of sustained research activity only recently. In addition to folic acid, the minerals zinc, iron and copper and the antioxidant vitamins A and E are of particular importance during pregnancy...
October 2001: Reproduction: the Official Journal of the Society for the Study of Fertility
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