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Bone morphogenic protein

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https://www.readbyqxmd.com/read/27922190/clc-3-promotes-osteogenic-differentiation-in-mc3t3-e1-cell-after-dynamic-compression
#1
Dawei Wang, Hao Wang, Feng Gao, Kun Wang, Fusheng Dong
ClC-3 chloride channel has been proved to have a relationship with the expression of osteogenic markers during osteogenesis, persistent static compression can upregulate the expression of ClC-3 and regulate osteodifferentiation in osteoblasts. However, there was no study about the relationship between the expression of ClC-3 and osteodifferentiation after dynamic compression. In this study, we applied dynamic compression on MC3T3-E1 cells to detect the expression of ClC-3, runt-related transcription factor 2 (Runx2), bone morphogenic protein-2 (BMP-2), osteopontin (OPN), nuclear-associated antigen Ki67 (Ki67) and proliferating cell nuclear antigen (PCNA) in biopress system, then we investigated the expression of these genes after dynamic compression with Chlorotoxin (specific ClC-3 chloride channel inhibitor) added...
December 6, 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27918081/st1926-attenuates-steroid-induced-osteoporosis-in-rats-by-inhibiting-inflammation-response
#2
Hong-Xing Zhao, Yuan-Xia Huang, Jin-Gang Tao
Steroid, also known as glucocorticoid, induced osteonecrosis of the femoral head in young adults, which has been a challenging disorder for the frequent incidence of collapse of femoral head, leading to dysfunction of hip joint and impairing life quality of human. Bioavailable and less toxic synthetic retinoids, such as the atypical adamantyl retinoid ST1926, have been developed and investigated in clinical trials for many diseases. Serum lipid-related indicators were assessed to elucidate the role of ST1926 in regulating lipid metabolism...
December 5, 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27911727/role-of-the-bone-morphogenic-protein-pathway-in-developmental-haemopoiesis-and-leukaemogenesis
#3
REVIEW
Parto Toofan, Helen Wheadon
Myeloid leukaemias share the common characteristics of being stem cell-derived clonal diseases, characterised by excessive proliferation of one or more myeloid lineage. Chronic myeloid leukaemia (CML) arises from a genetic alteration in a normal haemopoietic stem cell (HSC) giving rise to a leukaemic stem cell (LSC) within the bone marrow (BM) 'niche'. CML is characterised by the presence of the oncogenic tyrosine kinase fusion protein breakpoint cluster region-abelson murine leukaemia viral oncogene homolog 1 (BCR-ABL), which is responsible for driving the disease through activation of downstream signal transduction pathways...
October 15, 2016: Biochemical Society Transactions
https://www.readbyqxmd.com/read/27909654/bone-substitutes-and-expanders-in-spine-surgery-a-review-of-their-fusion-efficacies
#4
Abhijeet Kadam, Paul W Millhouse, Christopher K Kepler, Kris E Radcliff, Michael G Fehlings, Michael E Janssen, Rick C Sasso, James J Benedict, Alexander R Vaccaro
STUDY DESIGN: A narrative review of literature. OBJECTIVE: This manuscript intends to provide a review of clinically relevant bone substitutes and bone expanders for spinal surgery in terms of efficacy and associated clinical outcomes, as reported in contemporary spine literature. SUMMARY OF BACKGROUND DATA: Ever since the introduction of allograft as a substitute for autologous bone in spinal surgery, a sea of literature has surfaced, evaluating both established and newly emerging fusion alternatives...
2016: International Journal of Spine Surgery
https://www.readbyqxmd.com/read/27907211/characterization-and-immunomodulatory-effects-of-canine-adipose-tissue-and-bone-marrow-derived-mesenchymal-stromal-cells
#5
Keith A Russell, Natalie H C Chow, David Dukoff, Thomas W G Gibson, Jonathan LaMarre, Dean H Betts, Thomas G Koch
BACKGROUND: Mesenchymal stromal cells (MSC) hold promise for both cell replacement and immune modulation strategies owing to their progenitor and non-progenitor functions, respectively. Characterization of MSC from different sources is an important and necessary step before clinical use of these cells is widely adopted. Little is known about the biology and function of canine MSC compared to their mouse or human counterparts. This knowledge-gap impedes development of canine evidence-based MSC technologies...
2016: PloS One
https://www.readbyqxmd.com/read/27898568/whole-exome-sequencing-to-identify-novel-biological-pathways-associated-with-infertility-after-pelvic-inflammatory-disease
#6
Brandie D Taylor, Xiaojing Zheng, Toni Darville, Wujuan Zhong, Kranti Konganti, Olayinka Abiodun-Ojo, Roberta B Ness, Catherine M O'Connell, Catherine L Haggerty
BACKGROUND: Ideal management of sexually transmitted infections (STI) may require risk markers for pathology or vaccine development. Previously, we identified common genetic variants associated with chlamydial pelvic inflammatory disease (PID) and reduced fecundity. As this explains only a proportion of the long-term morbidity risk, we used whole-exome sequencing to identify biological pathways that may be associated with STI-related infertility. METHODS: We obtained stored DNA from 43 non-Hispanic black women with PID from the PID Evaluation and Clinical Health Study...
November 28, 2016: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27895117/examining-crosstalk-among-transforming-growth-factor-%C3%AE-bone-morphogen-protein-and-wnt-pathways
#7
Adam D Coster, Curtis A Thorne, Lani F Wu, Steve J Altschuler
The integration of morphogenic signals by cells is not well understood. A growing body of literature suggests increasingly complex coupling among classically defined pathways. Given this apparent complexity, it is difficult to predict where, when or even whether crosstalk occurs. Here, we investigated pairs of morphogenic pathways, previously reported to have multiple points of crosstalk, which either do not share (TGFβ; and Wnt/β-catenin) or share (TGFβ; and BMP) core signaling components. Crosstalk was measured by the ability of one morphogenic pathway to cross-activate core transcription factors and/or target genes of another morphogenic pathway...
November 28, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27885807/loading-of-bmp2-related-peptide-onto-three-dimensional-nano-hydroxyapatite-scaffolds-accelerates-mineralization-in-critical-sized-cranial-bone-defects
#8
Tingfang Sun, Kui Zhou, Man Liu, Xiaodong Guo, Yanzhen Qu, Wei Cui, ZengWu Shao, Xianglin Zhang, Shuyun Xu
Extrusion free-forming, as a rapid prototyping technique, is extensively applied in fabricating ceramic material in bone tissue engineering. To improve the osteoinductivity of nano-hydroxyapatite (nHA) scaffold fabricated by extrusion free-forming, in this study, we incorporated a new peptide (P28) and optimized the superficial microstructure after shaping by controlling the sintering temperature. P28, a novel bone morphogenic protein 2 (BMP-2)-related peptide, was designed in this study. Analysis of the structure, physicochemical properties, and release kinetics of P28 from nHA sintered at temperatures ranging from 1000 °C to 1400 °C revealed that nHA sintered at 1000 °C had higher porosity, preferable pore size, and better capacity to control P28 release than that sintered at other temperatures...
November 25, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27863509/profibrotic-mediators-in-tendon-disease-a-systematic-review
#9
Wataru Morita, Sarah Jane Bothwell Snelling, Stephanie Georgina Dakin, Andrew Jonathan Carr
BACKGROUND: Tendon disease is characterized by the development of fibrosis. Transforming growth factor beta (TGF-β), bone morphogenic proteins (BMPs) and connective tissue growth factor (CTGF) are key mediators in the pathogenesis of fibrotic disorders. The aim of this systematic review was to investigate the evidence for the expression of TGF-β, BMPs and CTGF along tendon disease progression and the response of tendon cells to these growth factors accordingly. METHOD: We conducted a systematic screen of the scientific literature using the Medline database...
November 18, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27852784/activity-induces-fmr1-sensitive-synaptic-capture-of-anterograde-circulating-neuropeptide-vesicles
#10
Samantha L Cavolo, Dinara Bulgari, David L Deitcher, Edwin S Levitan
: Synaptic neuropeptide and neurotrophin stores are maintained by constitutive bidirectional capture of dense-core vesicles (DCVs) as they circulate in and out of the nerve terminal. Activity increases DCV capture to rapidly replenish synaptic neuropeptide stores following release. However, it is not known whether this is due to enhanced bidirectional capture. Here experiments at the Drosophila neuromuscular junction, where DCVs contain neuropeptides and a bone morphogenic protein, show that activity-dependent replenishment of synaptic neuropeptides following release is evident after inhibiting the retrograde transport with the dynactin disruptor mycalolide B or photobleaching DCVs entering a synaptic bouton by retrograde transport...
November 16, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27848060/man1-restricts-bmp-signaling-during-synaptic-growth-in-drosophila
#11
Ulrike Laugks, Marie Hieke, Nicole Wagner
Bone morphogenic protein (BMP) signaling is crucial for coordinated synaptic growth and plasticity. Here, we show that the nuclear LEM-domain protein MAN1 is a negative regulator of synaptic growth at Drosophila larval and adult neuromuscular junctions (NMJs). Loss of MAN1 is associated with synaptic structural defects, including floating T-bars, membrane attachment defects, and accumulation of vesicles between perisynaptic membranes and membranes of the subsynaptic reticulum. In addition, MAN1 mutants accumulate more heterogeneously sized vesicles and multivesicular bodies in larval and adult synapses, the latter indicating that MAN1 may function in synaptic vesicle recycling and endosome-to-lysosome trafficking...
November 15, 2016: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/27843683/spinal-neuromodulation-as-a-novel-surgical-option-for-failed-back-surgery-syndrome-following-rhbmp-exuberant-bony-growth-in-instrumented-lumbar-fusion-a-case-report-and-literature-review
#12
Ramsis F Ghaly, Alexei Lissounov, Tatiana Tverdohleb, David Kohanchi, Kenneth D Candido, Nebojsa Nick Knezevic
BACKGROUND: Bone morphogenic protein (BMP) for instrumented lumbar fusion was approved in 2002, and since then has led to an increasing incidence of BMP-related neuropathic pain. These patients are usually resistant to conventional medical therapy and frequently undergo multiple surgical revisions without any pain relief. CASE DESCRIPTION: A 58-year-old male was referred to the author's outpatient clinic after four lumbar surgeries did not provide satisfactory pain relief...
2016: Surgical Neurology International
https://www.readbyqxmd.com/read/27836834/signaling-cross-talk-between-tgf-%C3%AE-smad-and-other-signaling-pathways
#13
Kunxin Luo
Cytokines of the transforming growth factor β (TGF-β) family, including TGF-βs, bone morphogenic proteins (BMPs), activins, and Nodal, play crucial roles in embryonic development and adult tissue homeostasis by regulating cell proliferation, survival, and differentiation, as well as stem-cell self-renewal and lineage-specific differentiation. Smad proteins are critical downstream mediators of these signaling activities. In addition to regulating the transcription of direct target genes of TGF-β, BMP, activin, or Nodal, Smad proteins also participate in extensive cross talk with other signaling pathways, often in a cell-type- or developmental stage-specific manner...
November 11, 2016: Cold Spring Harbor Perspectives in Biology
https://www.readbyqxmd.com/read/27829744/bone-morphogenetic-proteins-signaling-periodontal-bone-regeneration-and-repair
#14
REVIEW
G Sai Anusuya, M Kandasamy, S A Jacob Raja, S Sabarinathan, P Ravishankar, Balu Kandhasamy
Bone morphogenetic proteins (BMPs) are a group of growth factors also known as cytokines and as metabologens. Originally discovered by their ability to induce the formation of bone and cartilage, BMPs are now considered to constitute a group of pivotal morphogenetic signals, orchestrating tissue architecture throughout the body. The important functioning of BMP signals in physiology is emphasized by the multitude of roles for dysregulated BMP signaling in pathological processes. A study done wherein it was found that protein extracts from bone implanted into the animals at nonbone sites induced the formation of new cartilage and bone tissue...
October 2016: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/27826791/rational-derivation-extension-and-cyclization-of-self-inhibitory-peptides-to-target-tgf-%C3%AE-bmp-signaling-in-onfh
#15
Zhenhong Zhu, Chi Zhang, Wenqi Song
The human transforming growth factor β (TGF-β)/bone morphogenic protein (BMP) signaling has been recognized as an attractive target to suppress fibroblast activation in osteonecrosis of the femoral head (ONFH). Here, we reported successful derivation of a self-inhibitory peptide from the crystal complex interface of TGF-β with its cognate receptor TβRI using rational molecular design and in vitro binding assay. Computational modeling suggested that the peptide possesses a large flexibility and would incur considerable entropy penalty...
November 9, 2016: Amino Acids
https://www.readbyqxmd.com/read/27815469/effect-of-bmp2-platelet-rich-plasma-biphasic-calcium-phosphate-scaffold-on-accelerated-osteogenesis-in-mastoid-obliteration
#16
Chul Ho Jang, Cheol Hee Choi, Yong Beom Cho
The aim of this study was to evaluate the synergistic effect of platelet-rich plasma (PRP) and recombinant human bone morphogenic protein (BMP)-2 on accelerated osteogenesis of hydroxyapatite/β-tricalcium phosphate mixture and biphasic calcium phosphate (BCP) in mastoid obliteration. To the best of our knowledge, there have been no studies reporting the enhancing effects of BCP, combined with BMP2 and PRP, on osteogenesis in mastoid obliteration. Mastoid obliteration was performed in a control group (BCP only, n=7), a group treated with BMP2 and BCP (experimental group I, n=7), and a group treated with BMP2, PRP and BCP (experimental group II, n=7)...
November 2016: In Vivo
https://www.readbyqxmd.com/read/27815243/bmp4-acts-as-a-dorsal-telencephalic-morphogen-in-a-mouse-embryonic-stem-cell-culture-system
#17
Momoko Watanabe, Ernest S Fung, Felicia B Chan, Jessica S Wong, Margaret Coutts, Edwin S Monuki
The concept of a morphogen - a molecule that specifies two or more cell fates in a concentration-dependent manner - is paradigmatic in developmental biology. Much remains unknown, however, about the existence of morphogens in the developing vertebrate CNS, including the mouse dorsal telencephalic midline (DTM). Bone Morphogenetic Proteins (BMPs) are candidate DTM morphogens, and our previous work demonstrated BMP4 sufficiency to induce one DTM cell fate - that of choroid plexus epithelial cells (CPECs) - in a mouse embryonic stem cell (mESC) culture system...
November 4, 2016: Biology Open
https://www.readbyqxmd.com/read/27810548/immediate-transoral-allogeneic-bone-grafting-for-large-mandibular-defects-less-morbidity-more-bone-a-paradigm-in-benign-tumor-mandibular-reconstruction
#18
James C Melville, Nader N Nassari, Issa A Hanna, Jonathan W Shum, Mark E Wong, Simon Young
PURPOSE: Reconstruction of hard tissue continuity defects caused by ablative tumor surgery has been traditionally reconstructed with autogenous bone grafts or microvascular free flaps. Although results have been predictable from these 2 methods of reconstruction, the morbidity associated with bone harvest is quite serious for the patient. Predictable results have been obtained with using a combination of 100% cadaver bone, bone marrow aspirate concentrate (BMAC), and recombinant human bone morphogenic protein in immediate reconstruction for benign tumor extirpations through the extraoral approach...
October 6, 2016: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27809840/eif2ak4-mutation-as-second-hit-in-hereditary-pulmonary-arterial-hypertension
#19
Christina A Eichstaedt, Jie Song, Nicola Benjamin, Satenik Harutyunova, Christine Fischer, Ekkehard Grünig, Katrin Hinderhofer
BACKGROUND: Mutations in the eukaryotic translation initiation factor 2α kinase 4 (EIF2AK4) gene have recently been identified in recessively inherited veno-occlusive disease. In this study we assessed if EIF2AK4 mutations occur also in a family with autosomal dominantly inherited pulmonary arterial hypertension (HPAH) and incomplete penetrance of bone morphogenic protein receptor 2 (BMPR2) mutations. METHODS: Clinical examinations in a family with 10 members included physical examination, electrocardiogram, (stress)-echocardiography and lung function...
November 4, 2016: Respiratory Research
https://www.readbyqxmd.com/read/27782270/enhanced-bone-morphogenic-property-of-parylene-c
#20
Ya-Ting Tsai, Chao-Wei Huang, Hui-Yu Liu, Mei-Ching Huang, Ting-Pi Sun, Wen-Chien Chen, Chih-Yu Wu, Shih-Torng Ding, Hsien-Yeh Chen
The ability to induce osteointegration was introduced to a parylene-C surface via the simple and intuitive process of protein adsorption mediated by hydrophobic interactions. In this way, bone morphogenetic protein (BMP)-2, fibronectin, and platelet-rich plasma (PRP) could be immobilized on parylene-C surfaces. This approach alleviates concerns related to the use of potentially harmful substances in parylene-C modification processes. The adsorbed protein molecules were quantitatively characterized with respect to adsorption efficacy and binding affinity, and the important biological activities of the proteins were also examined using both early and late markers of osteogenetic activity, including alkaline phosphatase expression, calcium mineralization and marker gene expression...
October 26, 2016: Biomaterials Science
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