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https://www.readbyqxmd.com/read/29657845/long-term-bone-remodelling-around-legendary-cementless-femoral-stems
#1
Charles Rivière, Guido Grappiolo, Charles A Engh, Jean-Pierre Vidalain, Antonia-F Chen, Nicolas Boehler, Jihad Matta, Pascal-André Vendittoli
Bone remodelling around a stem is an unavoidable long-term physiological process highly related to implant design. For some predisposed patients, it can lead to periprosthetic bone loss secondary to severe stress-shielding, which is thought to be detrimental by contributing to late loosening, late periprosthetic fracture, and thus rendering revision surgery more complicated.However, these concerns remain theoretical, since late loosening has yet to be documented among bone ingrowth cementless stems demonstrating periprosthetic bone loss associated with stress-shielding...
February 2018: EFORT Open Reviews
https://www.readbyqxmd.com/read/29657443/healing-of-femoral-fractures-by-the-meaning-of-an-innovative-intramedullary-nail
#2
V Filardi
In this paper, an innovative design of nail, conceived to heal fractures of long bones has been investigated. Its functioning is based essentially on sliding of conical surfaces located in a spindle and in a series of holding pins radially disposed around it. Spindle and holding pins are connected together by means of a sleeve. Medial and distal screws are not necessary. Rotational and longitudinal motions of the spindle are transformed in a radial expansion of the holding pins by the sliding of conical surfaces...
March 2018: Journal of Orthopaedics
https://www.readbyqxmd.com/read/29657401/end-threaded-intramedullary-positive-profile-screw-ended-self-tapping-pin-admit-pin-a-cost-effective-novel-implant-for-fixing-canine-long-bone-fractures
#3
Mitin Chanana, Adarsh Kumar, Som Prakash Tyagi, Amit Kumar Singla, Arvind Sharma, Uiase Bin Farooq
Aim: The current study was undertaken to evaluate the clinical efficacy of end-threaded intramedullary pinning for management of various long bone fractures in canines. Materials and Methods: This study was conducted in two phases, managing 25 client-owned dogs presented with different fractures. The technique of application of end-threaded intramedullary pinning in long bone fractures was initially standardized in 6 clinical patients presented with long bone fractures...
February 2018: Veterinary World
https://www.readbyqxmd.com/read/29644572/low-magnitude-forces-for-bone-modeling-and-remodeling-in-dentofacial-orthopedics
#4
REVIEW
Achint Utreja
PURPOSE OF REVIEW: To examine the evidence in support of light continuous forces for enhancing bone adaptation (modeling and remodeling) in orthodontics and dentofacial orthopedics. RECENT FINDINGS: Clinical evidence suggests that light continuous orthodontic force can achieve physiologic expansion of the maxillary arch, but the long-term stability and the biological effects of the procedure are unclear. Compared to conventional orthodontic appliances that deliver heavy interrupted forces for tooth movement, the application of low-magnitude forces in animal models leads to anabolic modeling and remodeling of the alveolar bone in the path of orthodontic tooth movement...
April 11, 2018: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/29623650/multi-scale-approach-for-the-evaluation-of-bone-mineralization-in-strontium-ranelate-treated-diabetic-rats
#5
Pedro Álvarez-Lloret, Juan Manuel Fernández, María Silvina Molinuevo, Agustina Berenice Lino, José Luis Ferretti, Ricardo Francisco Capozza, Ana María Cortizo, Antonio Desmond McCarthy
Long-term diabetes mellitus can induce osteopenia and osteoporosis, an increase in the incidence of low-stress fractures, and/or delayed fracture healing. Strontium ranelate (SrR) is a dual-action anti-osteoporotic agent whose use in individuals with diabetic osteopathy has not been adequately evaluated. In this study, we studied the effects of an oral treatment with SrR and/or experimental diabetes on bone composition and biomechanics. Young male Wistar rats (half non-diabetic, half with streptozotocin/nicotinamide-induced diabetes) were either untreated or orally administered 625 mg/kg/day of SrR for 6 weeks...
April 5, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29614806/prediction-of-renal-acid-load-in-adult-patients-on-parenteral-nutrition
#6
Roberto Iacone, Clelia Scanzano, Anna D'Isanto, Andrea Vitalone, Ignazio Frangipane, Mariana D'Angeli, Lidia Santarpia, Franco Contaldo
Metabolic acidosis and metabolic bone disease are frequent complications in patients on parenteral nutrition (PN). A common contributor to these complications could be a daily high renal acid load. This study aims to find a method for predicting the potential total acid load (PTAL) and the pH of the compounded parenteral nutrition mixtures. The pH and titratable acidity (TA) of fifty compounded mixtures were measured. The potential metabolic acid load (PMAL) was calculated by considering the amount of nutrients that are acid producers and consumers...
April 2, 2018: Pharmaceutics
https://www.readbyqxmd.com/read/29613816/anterior-cruciate-ligament-reconstruction-affects-tibiofemoral-joint-congruency-during-dynamic-functional-movement
#7
Kanto Nagai, Tom Gale, James J Irrgang, Scott Tashman, Freddie H Fu, William Anderst
BACKGROUND: Anterior cruciate ligament reconstruction (ACLR) has been shown to alter kinematics, which may influence dynamic tibiofemoral joint congruency (a measure of how well the bone surfaces fit together). This may lead to abnormal loading of cartilage and joint degeneration. However, joint congruency after ACLR has never been investigated. HYPOTHESES: The ACLR knee will be more congruent than the contralateral uninjured knee, and dynamic congruency will increase over time after ACLR...
April 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29607519/long-term-effects-of-tibial-plateau-leveling-osteotomy-and-tibial-tuberosity-advancement-on-tibial-plateau-subchondral-bone-density-in-dogs
#8
Elizabeth S Leach, Ursula Krotscheck, Kelsey J Goode, Galina M Hayes, Peter Böttcher
OBJECTIVE: To evaluate long-term loading patterns using subchondral bone density (SBD) distribution of the tibial plateau after tibial plateau leveling osteotomy (TPLO) and tibial tuberosity advancement (TTA). STUDY DESIGN: Cross-sectional study. ANIMALS: Adult (> 2 years), medium to large breed dogs (>20 kg) that had been treated with TPLO or TTA at least 1 year prior to the study were recruited. A normal cohort of similar age and weight dogs with normal physical and orthopedic examinations served as control...
April 1, 2018: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/29600975/highly-activated-carbon-enterosorbent-mediates-the-suppression-of-paraneoplastic-syndrome-associated-with-lewis-lung-carcinoma-in-mice
#9
V V Sarnatskaya, L Sakhno, L M Paziuk, L A Yushko, N K Rodionova, V N Maslenniy, A S Sidorenko, V Nikolaev
AIM: To investigate the effect of enterosorption on the development of paraneoplastic syndrome in mice with Lewis lung carcinoma (LLC). MATERIALS AND METHODS: The study was performed on male С57/ВL6 mice with transplanted LLC. As an enterosorbent, highly activated powder fraction of HSGD was administered per os daily at a dose of 0.625 g/kg for two weeks starting from the 7th day after tumor cell transplantation. Analysis of hemo- and myelograms, morphological alterations in vital organs, the activities of catalase and superoxide dismutase, biochemical analysis of blood and quantitative analysis of hydroperoxides, malonic dialdehyde, аdvanced oxidation protein products was carried out by standard methods after completing the course of enterosorption...
March 2018: Experimental Oncology
https://www.readbyqxmd.com/read/29593958/3d-bioprinted-osteoblast-laden-nanocomposite-hydrogel-constructs-with-induced-microenvironments-promote-cell-viability-differentiation-and-osteogenesis-both-in-vitro-and-in-vivo
#10
Xinyun Zhai, Changshun Ruan, Yufei Ma, Delin Cheng, Mingming Wu, Wenguang Liu, Xiaoli Zhao, Haobo Pan, William Weijia Lu
An osteoblast-laden nanocomposite hydrogel construct, based on polyethylene glycol diacrylate (PEGDA)/laponite XLG nanoclay ([Mg5.34 Li0.66 Si8 O20 (OH)4 ]Na0.66, clay )/hyaluronic acid sodium salt (HA) bio-inks, is developed by a two-channel 3D bioprinting method. The novel biodegradable bio-ink A, comprised of a poly(ethylene glycol) (PEG)-clay nanocomposite crosslinked hydrogel, is used to facilitate 3D-bioprinting and enables the efficient delivery of oxygen and nutrients to growing cells. HA with encapsulated primary rat osteoblasts (ROBs) is applied as bio-ink B with a view to improving cell viability, distribution uniformity, and deposition efficiency...
March 2018: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/29593719/human-milk-oligosaccharide-2-fucosyllactose-improves-innate-and-adaptive-immunity-in-an-influenza-specific-murine-vaccination-model
#11
Ling Xiao, Thea Leusink-Muis, Nienke Kettelarij, Ingrid van Ark, Bernadet Blijenberg, Nienke A Hesen, Bernd Stahl, Saskia A Overbeek, Johan Garssen, Gert Folkerts, Belinda Van't Land
Background: Human milk is uniquely suited to provide optimal nutrition and immune protection to infants. Human milk oligosaccharides are structural complex and diverse consisting of short chain and long chain oligosaccharides typically present in a 9:1 ratio. 2'-Fucosyllactose (2'FL) is one of the most prominent short chain oligosaccharides and is associated with anti-infective capacity of human milk. Aim: To determine the effect of 2'FL on vaccination responsiveness (both innate and adaptive) in a murine influenza vaccination model and elucidate mechanisms involved...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29577017/high-density-human-mesenchymal-stem-cell-rings-with-spatiotemporally-controlled-morphogen-presentation-as-building-blocks-for-engineering-bone-diaphyseal-tissue
#12
Samuel Herberg, Daniel Varghai, Yuxuan Cheng, Anna D Dikina, Phuong N Dang, Marsha W Rolle, Eben Alsberg
Emerging biomimetic tissue engineering strategies aim to partially recapitulate fundamental events that transpire during embryonic skeletal development; namely, cellular self-organization and targeted morphogenetic pathway activation. Here, we describe self-assembled, scaffold-free human mesenchymal stem cell (hMSC) rings featuring microparticle-mediated presentation of transforming growth factor-β1 (TGF-β1) and bone morphogenetic protein-2 (BMP-2). We tested the hypothesis that spatiotemporally-controlled dual presentation of TGF-β1 and BMP-2 is superior in modulating in vitro endochondral ossification of high-density cellular constructs compared to single morphogen delivery...
2018: Nanotheranostics
https://www.readbyqxmd.com/read/29569767/marginal-bone-loss-at-implants-with-different-surface-characteristics-a-20-year-follow-up-of-a-randomized-controlled-clinical-trial
#13
Mauro Donati, Annika Ekestubbe, Jan Lindhe, Jan L Wennström
OBJECTIVE: This report is a 20-year follow-up of a randomized controlled clinical trial evaluating the potential long-term effect of a modified implant surface on the preservation of the peri-implant marginal bone level. MATERIAL & METHODS: In each of 51 patients and for each fixed partial denture (FPD), by randomization at least one implant installed had a non-modified turned surface and one a modified and roughened surface (TiOblast® ). Clinical and radiological examinations were performed at various follow-up intervals...
March 23, 2018: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/29565773/a-novel-partial-gravity-ground-based-analogue-for-rats-via-quadrupedal-unloading
#14
Marie Mortreux, Janice A Nagy, Frank C Ko, Mary L Bouxsein, Seward B Rutkove
Musculoskeletal deconditioning is a well-known consequence of microgravity; however, the effects of partial gravity such as that experienced on the Moon (0.16g) or Mars (0.38g) on musculoskeletal health remain relatively unexplored. Since Mars is being increasingly viewed as the likely next extraterrestrial site for human exploration, there is an increasing need for earth-based analogue models that can study the long-term physiological effects of such environments. Moreover, this model would also offer the opportunity to explore the potential impact of partial artificial gravity (as would be achieved centrifugation)...
March 22, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29557400/posterior-atrophic-jaws-rehabilitated-with-prostheses-supported-by-5-%C3%A3-5-mm-implants-with-a-nanostructured-calcium-incorporated-titanium-surface-or-by-longer-implants-in-augmented-bone-3-year-results-from-a-randomised-controlled-trial
#15
Giorgio Gastaldi, Pietro Felice, Valeria Pistilli, Carlo Barausse, Daniela Rita Ippolito, Marco Esposito
PURPOSE: To evaluate whether 5.0 × 5.0 mm dental implants with a novel nanostructured calcium-incorporated titanium surface could be an alternative to implants of at least 10.0 mm long placed in bone augmented with bone substitutes in posterior atrophic jaws. MATERIALS AND METHODS: Forty patients with atrophic posterior (premolar and molar areas) mandibles with 5.0 mm to 7.0 mm bone height above the mandibular canal, and 40 patients with atrophic maxillas with 4...
2018: European Journal of Oral Implantology
https://www.readbyqxmd.com/read/29557399/4-mm-long-vs-longer-implants-in-augmented-bone-in-posterior-atrophic-jaws-1-year-post-loading-results-from-a-multicentre-randomised-controlled-trial
#16
Caroline Bolle, Pietro Felice, Carlo Barausse, Valeria Pistilli, Anna Trullenque-Eriksson, Marco Esposito
PURPOSE: To evaluate whether 4.0 mm short dental implants could be an alternative to augmentation with xenographs in the maxilla and placement of at least 10.0 mm long implants in posterior atrophic jaws. MATERIALS AND METHODS: A group of 40 patients with atrophic posterior (premolar and molar areas) mandibles with 5.0 mm to 6.0 mm bone height above the mandibular canal and 40 patients with atrophic maxillas having 4.0 mm to 5.0 mm below the maxillary sinus, were randomised according to a parallel group design to receive between one and three 4...
2018: European Journal of Oral Implantology
https://www.readbyqxmd.com/read/29557398/immediately-loaded-zygomatic-implants-vs-conventional-dental-implants-in-augmented-atrophic-maxillae-4-months-post-loading-results-from-a-multicentre-randomised-controlled-trial
#17
Marco Esposito, Rubén Davó, Carlos Marti-Pages, Ada Ferrer-Fuertes, Carlo Barausse, Roberto Pistilli, Daniela Rita Ippolito, Pietro Felice
PURPOSE: To compare the clinical outcome of immediately loaded cross-arch maxillary prostheses supported by zygomatic implants vs conventional implants placed in augmented bone. MATERIALS AND METHODS: A total of 71 edentulous patients with severely atrophic maxillas, who did not have sufficient bone volume to place dental implants or when it was possible to place only two implants in the front area (minimal diameter 3.5 mm and length of 8 mm) and less than 4.0 mm of bone height subantrally, were randomised according to a parallel group design...
2018: European Journal of Oral Implantology
https://www.readbyqxmd.com/read/29556114/the-effect-of-drill-hole-location-on-load-bearing-capacity-of-long-bones
#18
Christopher James Yiachos, Subrata Saha
We investigated how load bearing capacity (LBC) of long bone differs with a bicortical drill hole in a compressive/tensile location vs. a neutral location. Group I had a hole drilled through 0°/180° ([compressive at 0°/maximum tensile at 180°]), Group II at 90°/270° ([neutral]), and Group III at 135°/315° ([tensile at 135°/compressive at 315°]). Maximum load at failure and stiffness was measured. A significant ([ p  < 0.05]) decrease in LBC of all Group I and Group III bones was observed. Loss of strength for Group II was statistically insignificant ([ p  > 0...
June 2018: Journal of Orthopaedics
https://www.readbyqxmd.com/read/29543928/injectable-bone-substitute-material-on-the-basis-of-%C3%AE-tcp-and-hyaluronan-achieves-complete-bone-regeneration-while-undergoing-nearly-complete-degradation
#19
Jonas Lorenz, Mike Barbeck, Charles James Kirkpatrick, Robert Sader, Henriette Lerner, Shahram Ghanaati
PURPOSE: In this prospective study, the regenerative potential and pathways of a new injectable bone substitute (IBS) material composed of beta-tricalcium phosphate (β-TCP) and hyaluronan were investigated for its application in alveolar bone regeneration within extraction sockets. MATERIALS AND METHODS: The bone substitute material was implanted in 44 extraction sockets after removal of teeth not worth preserving in the maxillary and mandibular arches of 21 patients...
March 15, 2018: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/29534132/immediate-loading-of-tilted-and-axial-posterior-implants-in-the-edentulous-maxillary-arch-a-retrospective-comparison-of-5-year-outcomes
#20
Joseph A Toljanic, Karl Ekstrand, Russell A Baer, Andreas Thor
PURPOSE: The purpose of this study was to retrospectively compare long-term outcomes for immediately loaded tilted and axial implants placed in the posterior region of the edentulous maxillary arch. MATERIALS AND METHODS: Data obtained from a 5-year prospective study designed to assess clinical outcomes following immediate loading of implants with screw-retained fixed restorations in the edentulous maxillary arch were retrospectively reviewed. Where insufficient alveolar bone was available for axial placement of the posterior-most implant on each side of the arch, tilted placement was employed...
March 2018: International Journal of Oral & Maxillofacial Implants
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