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https://www.readbyqxmd.com/read/28925539/expression-and-functional-proteomic-analyses-of-osteocytes-from-xenopus-laevis-tested-under-mechanical-stress-conditions-preliminary-observations-on-an-appropriate-new-animal-model
#1
Jessika Bertacchini, Marta Benincasa, Marta Checchi, Francesco Cavani, Alberto Smargiassi, Marzia Ferretti, Carla Palumbo
Hitherto, the role of the osteocyte as transducer of mechanical stimuli into biological signals is far from settled. In this study, we used an appropriate model represented by the cortex of Xenopus laevis long bone diaphysis lacking (unlike the mammalian one) of vascular structures and containing only osteocytes inside the bone matrix. These structural features allow any change of protein profile that might be observed upon different experimental conditions, such as bone adaptation to stress/mechanical loading, to be ascribed specifically to osteocytes...
September 19, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/28916544/muscle-deficits-in-rheumatoid-arthritis-contribute-to-inferior-cortical-bone-structure-and-trabecular-bone-mineral-density
#2
Joshua F Baker, Jin Long, Sogol Mostoufi-Moab, Michele Denburg, Erik Jorgenson, Prerna Sharma, Babette S Zemel, Elena Taratuta, Said Ibrahim, Mary B Leonard
OBJECTIVE: Rheumatoid arthritis (RA) is associated with muscle loss, osteoporosis, and fracture. We examined associations between skeletal muscle mass, strength, and quality and trabecular and cortical bone deficits in patients with RA and healthy controls. METHODS: Participants, ages 18-75 years, completed whole-body dual-energy x-ray absorptiometry and peripheral quantitative computed tomography (pQCT) of the tibia to quantify appendicular lean mass and fat mass indices (ALMI, FMI), muscle density at the lower leg, trabecular bone density, and cortical bone thickness...
September 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28906506/stability-of-grafted-implant-placement-sites-after-sinus-floor-elevation-using-a-layering-technique-10-year-clinical-and-radiographic-results
#3
Fouad Khoury, Pierre Keller, Philip L Keeve
PURPOSE: To evaluate long-term survival rates and radiographic stability of sinus floor elevations carried out using a two-layer grafting technique. MATERIALS AND METHODS: Records were analyzed for patients treated with sinus floor elevations using a modified technique. Phycogenic hydroxyapatite (Algipore, Dentsply Sirona Implants) and autogenous bone particles harvested from intraoral sites were grafted in two distinct layers after elevation of the sinus mucosae...
September 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28899823/a-predictive-radiological-analysis-of-short-stems-versus-both-shortened-and-long-stems-in-primary-hip-replacement-a-case-control-study-of-100-cases-of-metha-versus-abg-ii-and-omnifit-ha-at-2-8-years-follow-up
#4
Jean-Alain Epinette, Michel Brax, Yves Chammaï
INTRODUCTION: Short hip stems, intended to conserve bone stock and ensure a more physiological distribution of stress in the femur under loading, are meeting with renewed interest. Radiologic semiology is not known exactly, particularly in relation to conventional implants; we therefore conducted a case-control study of 3 types of implant differing only in stem length: short, shortened or long. The aim was 1) to compare radiographic aspects, 2) to attempt to systematize medium-term radiologic status for the 3 types, and 3) to assess the impact of radiographic aspect on loosening and revision rates...
September 9, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28893629/obesity-and-type-2-diabetes-not-a-diet-high-in-fat-sucrose-and-cholesterol-negatively-impacts-bone-outcomes-in-the-hyperphagic-otsuka-long-evans-tokushima-fatty-rat
#5
Laura C Ortinau, Melissa A Linden, Rebecca Dirkes, R Scott Rector, Pamela S Hinton
BACKGROUND: Obesity and type 2 diabetes (T2D) increase fracture risk; however, the association between obesity/T2D may be confounded by consumption of a diet high in fat, sucrose, and cholesterol (HFSC). OBJECTIVE: The study objective was to determine the main and interactive effects of obesity/T2D and a HFSC diet on bone outcomes using hyperphagic Otuska Long Evans Tokushima Fatty (OLETF) rats and normophagic Long Evans Tokushima Otsuka (LETO) controls. METHODS: At 8weeks of age, male OLETF and LETO rats were randomized to either a control (CON, 10 en% from fat as soybean oil) or HFSC (45 en% from fat as soybean oil/lard, 17 en% sucrose, and 1wt%) diet, resulting in four treatment groups...
September 9, 2017: Bone
https://www.readbyqxmd.com/read/28888934/femoral-stem-incorporating-a-diamond-cubic-lattice-structure-design-manufacture-and-testing
#6
Bruno Jetté, Vladimir Brailovski, Mathieu Dumas, Charles Simoneau, Patrick Terriault
BACKGROUND: The current total hip prostheses with dense femoral stems are considerably stiffer than the host bones, which leads to such long-term complications as aseptic loosening, and eventually, the need for a revision. Consequently, the lifetime of the implantation does not match the lifetime expectation of young patients. METHOD: A femoral stem design featuring a porous structure is proposed to lower its stiffness and allow bone tissue ingrowth. The porous structure is based on a diamond cubic lattice in which the pore size and the strut thickness are selected to meet the biomechanical requirements of the strength and the bone ingrowth...
August 31, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28875278/investigation-of-peri-implant-tissue-conditions-and-peri-implant-tissue-stability-in-implants-placed-with-simultaneous-augmentation-procedure-a-3-year-retrospective-follow-up-analysis-of-a-newly-developed-bone-level-implant-system
#7
Jonas Lorenz, Henriette Lerner, Robert A Sader, Shahram Ghanaati
BACKGROUND: Guided bone regeneration (GBR) has been proven to be a reliable therapy to regenerate missing bone in cases of atrophy of the alveolar crest. The aim of the present retrospective analysis was to assess peri-implant tissue conditions and document peri-implant tissue stability in C-Tech implants when placed simultaneously with a GBR augmentation procedure. METHODS: A total of 47 implants, which were placed simultaneously with a GBR procedure with a synthetic bone substitute material in 20 patients, were investigated clinically and radiologically at least 3 years after loading...
September 5, 2017: International Journal of Implant Dentistry
https://www.readbyqxmd.com/read/28870417/characterization-of-an-innovative-intramedullary-nail-for-diaphyseal-fractures-of-long-bones
#8
V Filardi
In this paper, an innovative design of nail for fractures occurring on long bones has been investigated. Its functioning is based essentially on sliding of conical surfaces, located in a spindle and in holding pins. Spindle and holding pins are connected together by a sleeve. The sliding transforms the rotational and translational motion of the spindle to a radial expansion of the holding pins, protruding inside the intramedullary canal. In order to evaluate mechanical behavior of the prosthesis different benchmarks and tests were numerically performed by an FE code...
September 1, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28867598/intracranial-and-hierarchical-perspective-on-dietary-plasticity-in-mammals
#9
Erin M Franks, Jeremiah E Scott, Kevin R McAbee, Joseph P Scollan, Meghan M Eastman, Matthew J Ravosa
The effect of dietary properties on craniofacial form has been the focus of numerous functional studies, with increasingly more work dedicated to the importance of phenotypic plasticity. As bone is a dynamic tissue, morphological variation related to differential loading is well established for many masticatory structures. However, the adaptive osteogenic response of several cranial sites across multiple levels of bony organization remains to be investigated. Here, rabbits were obtained at weaning and raised for 48 weeks until adulthood in order to address the naturalistic influence of altered loading on the long-term development of masticatory and non-masticatory elements...
March 16, 2017: Zoology: Analysis of Complex Systems, ZACS
https://www.readbyqxmd.com/read/28866149/three-dimensional-finite-element-analysis-of-occlusal-splint-and-implant-connection-on-stress-distribution-in-implant-supported-fixed-dental-prosthesis-and-peri-implantal-bone
#10
Vívian Dos Santos Marsico, Roberto Brunow Lehmann, Cristiane Aparecida de Assis Claro, Marina Amaral, Rafael Pino Vitti, Ana Christina Claro Neves, Lais Regiane da Silva Concilio
The aim of this study was to investigate the influence of occlusal splint therapy on the stress distribution of implant-supported fixed dental prosthesis (FDP) and peri-implantal bone structures using three-dimensional (3D) finite element analysis (FEA). The system consisted of two implants (positioned on region of second premolar and second molar) as retainers of fixed porcelain-fused-to-metal 3-unit FDP (first molar as pontic element). Two implant connections systems (external and internal hexagon) were tested...
November 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28861287/marginal-bone-level-changes-in-association-with-different-vertical-implant-positions-a-3-year-retrospective-study
#11
Yeon-Tae Kim, Gyu-Hyung Lim, Jae-Hong Lee, Seong-Nyum Jeong
PURPOSE: To retrospectively evaluate the relationship between the vertical position of the implant-abutment interface and marginal bone loss over 3 years using radiological analysis. METHODS: In total, 286 implant surfaces of 143 implants from 61 patients were analyzed. Panoramic radiographic images were taken immediately after implant installation and at 6, 12, and 36 months after loading. The implants were classified into 3 groups based on the vertical position of the implant-abutment interface: group A (above bone level), group B (at bone level), and group C (below bone level)...
August 2017: Journal of Periodontal & Implant Science
https://www.readbyqxmd.com/read/28834387/evaluation-of-a-platelet-lysate-bi-layered-system-for-periodontal-regeneration-in-a-rat-intrabony-3-wall-periodontal-defect
#12
Pedro S Babo, Xinjie Cai, Adelina S Plachokova, Rui L Reis, John Jansen, Manuela E Gomes, X Frank Walboomers
With currently available therapies, full regeneration of lost periodontal tissues after periodontitis cannot be achieved. In this study, a combined compartmentalized system was tested, composed of (1) a platelet lysate (PL)-based construct, which was placed along the root aiming to regenerate the root cementum and periodontal ligament, and (2) a calcium phosphate cement composite incorporated with hyaluronic acid microspheres loaded with PL, aiming to promote the regeneration of alveolar bone. This bi-layered system was assessed in a 3-wall periodontal defect in Wistar rats...
August 17, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28828342/effect-of-intravenous-morphine-and-ketorolac-on-pain-control-in-long-bones-fractures
#13
Babak Masoumi, Behdad Farzaneh, Omid Ahmadi, Farhad Heidari
BACKGROUND: According to the lack of adequate studies on comparing the analgesic effect and complications of ketorolac with morphine in long bone fractures, this study aimed to compare the efficacy of ketorolac with morphine in patients referring to the Emergency Department with long bones damage and fracture. MATERIALS AND METHODS: In this clinical trial study, 88 patients with long bone fracture were selected randomly and divided into two groups. To scale the intensity of pain, visual analog scale (VAS) were used...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28828263/the-effects-of-captive-versus-wild-rearing-environments-on-long-bone-articular-surfaces-in-common-chimpanzees-pan-troglodytes
#14
Kristi L Lewton
The physical environments of captive and wild animals frequently differ in substrate types and compliance. As a result, there is an assumption that differences in rearing environments between captive and wild individuals produce differences in skeletal morphology. Here, this hypothesis is tested using a sample of 42 captive and wild common chimpanzees (Pan troglodytes). Articular surface areas of the humerus, radius, ulna, femur, and tibia were calculated from linear breadth measurements, adjusted for size differences using Mosimann shape variables, and compared across sex and environmental groups using two-way ANOVA...
2017: PeerJ
https://www.readbyqxmd.com/read/28820012/effect-of-rotational-prosthetic-alignment-variation-on-tibiofemoral-contact-pressure-distribution-and-joint-kinematics-in-total-knee-replacement
#15
Xin Xie, Roy Rusly, John D DesJardins, Frank Voss, Kim Chillag, Martine LaBerge
In total knee replacement surgery, implant alignment is one of the most important criteria for successful long-term clinical outcome. During total knee replacement implantation, femoral and tibial alignment are determined through appropriate bone resections, which could vary based on patient anatomy, implant design and surgical technique and further influence loading conditions and clinical outcomes. The current research focused on three critical alignment parameters for total knee replacement insertion: femoral component internal/external (I/E) rotation, varus-valgus tibiofemoral angulation and posterior tibial slope...
August 1, 2017: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/28817138/influence-of-abutment-height-on-maintenance-of-peri-implant-crestal-bone-at-bone-level-implants-a-3-year-follow-up-study
#16
Lourdes Nóvoa, Pilar Batalla, Leticia Caneiro, Alexandre Pico, Antonio Liñares, Juan Blanco
In this 3-year follow-up study, peri-implant bone loss at bone-level implants was evaluated with two definitive abutment heights: 1 mm and 2.5 mm. Peri-implant bone loss was defined as the distance between the implant shoulder and the first bone-to-implant contact from the time of loading to the 36-month follow-up, estimated using periapical radiographs. The bone loss was increased at the time of follow-up, to 1.30 mm (95% confidence interval [CI]: 0.70-1.89 mm; SD = 1.89) and 0.33 mm (95% CI: 0.11-0.55; SD = 0...
September 2017: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/28816874/does-surgical-intervention-or-timing-of-surgery-have-an-effect-on-neurological-recovery-in-the-setting-of-a-thoracolumbar-burst-fracture
#17
So Kato, Jean-Christophe Murray, Brian K Kwon, Gregory D Schroeder, Alexander R Vaccaro, Michael G Fehlings
Traumatic thoracolumbar burst fractures are one of the most common forms of spinal trauma with the majority occurring at the junctional area where mechanical load is maximal (AOSpine Thoracolumbar Spine Injury Classification System Subtype A3 or A4). Burst fractures entail the involvement of the middle column, and therefore, they are typically associated with bone fragment in the spinal canal, which may cause compression of the spinal cord, conus medullaris, cauda equina, or a combination of these. Fortunately, approximately half of the patients with thoracolumbar burst fractures are neurologically intact due to the wide canal diameter...
September 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28795294/how-long-does-antimycobacterial-antibiotic-loaded-bone-cement-have-in-vitro-activity-for-musculoskeletal-tuberculosis
#18
Jae Hoo Lee, Chang Dong Han, Sang-Nae Cho, Ick Hwan Yang, Woo Suk Lee, Seung-Hun Baek, Jae Won Shin, Khalid Elfadil Ibrahim Husein, Kwan Kyu Park
BACKGROUND: Antibiotic-loaded bone cement is accepted as an effective treatment modality for musculoskeletal tuberculosis. However, comparative information regarding combinations and concentrations of second-line antimycobacterial drugs, such as streptomycin and amoxicillin and clavulanic acid, are lacking. QUESTIONS/PURPOSES: (1) In antibiotic-loaded cement, is there effective elution of streptomycin and Augmentin(®) (amoxicillin and clavulanic acid) individually and in combination? (2) What is the antibacterial activity duration for streptomycin- and amoxicillin and clavulanic acid -loaded cement? METHODS: Six different types of bone cement discs were created by mixing 40 g bone cement with 1 or 2 g streptomycin only, 0...
August 9, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28789651/effect-of-athletic-fatigue-damage-and-the-associated-bone-targeted-remodeling-in-the-rat-ulna
#19
Li Hao, Li Rui-Xin, Han Biao, Zhao Bin, Hao Bao-Hui, Liu Ying-Jie, Zhang Xi-Zheng
BACKGROUND: Fatigue damage of the long bones is prevalent in running athletes and military recruits due to vigorous mid- and long-term physical activity. The current study attempted to know the features of bony athletic fatigue damage and to explore the mechanism of fatigue damage repair through bone targeted remodeling process. METHODS: Right ulnae of the Wistar rats were fatigue loaded on an INSTRON 5865 to construct the athletic fatigue damage model, and several time points (i...
August 8, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28775205/therapy-related-hematological-malignancies-after-peptide-receptor-radionuclide-therapy-with-177-lu-dota-octreotate-incidence-course-predicting-factors-in-patients-with-gep-nets
#20
Hendrik Bergsma, Kirsten van Lom, Mark Konijnenberg, Boen Kam, Jaap Teunissen, Wouter de Herder, Eric Krenning, Dik Kwekkeboom
Peptide Receptor Radionuclide Therapy (PRRT) may induce long-term toxicity to the bone marrow (BM). The aim of this study was to analyze persistent dysfunction of the hematopoietic system after PRRT with (177)Lu-DOTATATE in patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs). Methods: The incidence and course of persistent hematological dysfunction (PHD) was analyzed in 274 (=GEP-NET) out of 367 patients with somatostatin receptor-positive tumors. PHD was defined as diagnosis of Myelodysplastic Syndrome (MDS), Acute Myeloid Leukemia (AML), Myeloproliferative Neoplasms (MPN), Myelodysplastic/Myeloproliferative neoplasms (MDS/MPN) or otherwise unexplained cytopenia (for more than 6 months)...
August 3, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
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