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https://www.readbyqxmd.com/read/29452946/time-responsive-osteogenic-niche-of-stem-cells-a-sequentially-triggered-dual-peptide-loaded-alginate-hybrid-system-for-promoting-cell-activity-and-osteo-differentiation
#1
Zuyuan Luo, Siqi Zhang, Jijia Pan, Rui Shi, Hao Liu, Yalin Lyu, Xiao Han, Yan Li, Yue Yang, Zhixiu Xu, Yi Sui, En Luo, Yuanyuan Zhang, Shicheng Wei
The efficacy of stem cell-based bone tissue engineering has been hampered by cell death and limited fate control. A smart cell culture system with the capability of sequentially delivering multiple factors in specific growth stages, like the mechanism of the natural extracellular matrix modulating tissue formation, is attractive for enhancing cell activity and controlling cell fate. Here, a bone forming peptide-1 (BFP-1)-laden mesoporous silica nanoparticles (pep@MSNs) incorporated adhesion peptide, containing the arginine-glycine-aspartic acid (RGD) domain, modified alginate hydrogel (RA) system (pep@MSNs-RA) was developed to promote the activity and stimulate osteo-differentiation of human mesenchymal stem cells (hMSCs) in sequence...
February 10, 2018: Biomaterials
https://www.readbyqxmd.com/read/29444703/whole-bone-testing-in-small-animals-systematic-characterization-of-the-mechanical-properties-of-different-rodent-bones-available-for-rat-fracture-models
#2
Peter M Prodinger, Peter Foehr, Dominik Bürklein, Oliver Bissinger, Hakan Pilge, Kilian Kreutzer, Rüdiger von Eisenhart-Rothe, Thomas Tischer
OBJECTIVES: Rat fracture models are extensively used to characterize normal and pathological bone healing. Despite, systematic research on inter- and intra-individual differences of common rat bones examined is surprisingly not available. Thus, we studied the biomechanical behaviour and radiological characteristics of the humerus, the tibia and the femur of the male Wistar rat-all of which are potentially available in the experimental situation-to identify useful or detrimental biomechanical properties of each bone and to facilitate sample size calculations...
February 14, 2018: European Journal of Medical Research
https://www.readbyqxmd.com/read/29440901/guided-osteoporotic-bone-regeneration-with-composite-scaffolds-of-mineralized-ecm-heparin-membrane-loaded-with-bmp2-related-peptide
#3
Tingfang Sun, Man Liu, Sheng Yao, Yanhui Ji, Lei Shi, Kai Tang, Zekang Xiong, Fan Yang, Kaifang Chen, Xiaodong Guo
Introduction: At present, the treatment of osteoporotic defects poses a great challenge to clinicians, owing to the lower regeneration capacity of the osteoporotic bone as compared with the normal bone. The guided bone regeneration (GBR) technology provides a promising strategy to cure osteoporotic defects using bioactive membranes. The decellularized matrix from the small intestinal submucosa (SIS) has gained popularity for its natural microenvironment, which induces cell response. Materials and methods: In this study, we developed heparinized mineralized SIS loaded with bone morphogenetic protein 2 (BMP2)-related peptide P28 (mSIS/P28) as a novel GBR membrane for guided osteoporotic bone regeneration...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29436942/short-vs-longer-implants-in-mandibular-alveolar-ridge-augmentated-using-osteogenic-distraction-one-year-follow-up-of-a-randomized-split-mouth-trial
#4
Sara Bernardi, Roberto Gatto, Marco Severino, Gianluca Botticelli, Silvia Caruso, Claudio Rastelli, Ettore Lupi, Adolfo Quiroz Rojas, Enzo Iacomino, Giovanni Falisi
Aim of the study was to evaluate the reliability of 6 mm long implants compared to normal length implants placed in vertical augmented atrophic posterior mandible, supporting cemented single crowns. Thirty-six patients with bilateral posterior edentulous mandible and presented a bone availability height less than 9 mm from the mandibular canal were enrolled for the participation to this study. Patient hemi-arches were randomized to receive both 6 mm-long and normal length implants (10 mm). The technique used for the vertical bone augmentation was the "sandwich" technique, using a bone substitute block as graft...
February 13, 2018: Journal of Oral Implantology
https://www.readbyqxmd.com/read/29421350/long-term-evaluation-of-osteoarthritis-sheep-knee-treated-with-tgf-%C3%AE-3-and-bmp-6-induced-multipotent-stem-cells
#5
C C Ude, B S Shamsul, M H Ng, H C Chen, Htwe Ohnmar, S N Amaramalar, A R Rizal, A Johan, M Y Norhamdan, M Azizi, B S Aminuddin, B H I Ruszymah
BACKGROUND: Hyaline articular cartilage, which protects the bones of diarthrodial joints from forces associated with load bearing, frictions, and impacts has very limited capacities for self-repair. Over the years, the trend of treatments has shifted to regenerations and researchers have been on the quest for a lasting regeneration. We evaluated the treatment of osteoarthritis by chondrogenically induced ADSCs and BMSCs for a long time functional recovery. METHODS: Osteoarthritis was induced at the right knee of sheep by complete resection of ACL and medial meniscus...
January 29, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29415416/nano-biocomposite-scaffolds-of-chitosan-carboxymethyl-cellulose-and-silver-nanoparticle-modified-cellulose-nanowhiskers-for-bone-tissue-engineering-applications
#6
Abshar Hasan, Gyan Waibhaw, Varun Saxena, Lalit M Pandey
In the present work, we aimed to synthesize highly efficient nano-composite polymeric scaffolds with controllable pore size and mechanical strength. We prepared nanocomposite (CCNWs-AgNPs) of silver nanoparticles (AgNPs) decorated on carboxylated CNWs (CCNWs) which serves dual functions of providing mechanical strength and antimicrobial activity. Scaffolds containing chitosan (CS) and carboxymethyl cellulose (CMC) with varying percent of nanocomposite were fabricated using freeze drying method. XRD and FESEM analysis of nanocomposite revealed highly crystalline structure with AgNPs (5...
February 1, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29414477/effect-of-porous-orthopaedic-implant-material-and-structure-on-load-sharing-with-simulated-bone-ingrowth-a-finite-element-analysis-comparing-titanium-and-peek
#7
R Dana Carpenter, Brett S Klosterhoff, F Brennan Torstrick, Kevin T Foley, J Kenneth Burkus, Christopher S D Lee, Ken Gall, Robert E Guldberg, David L Safranski
Osseointegration of load-bearing orthopaedic implants, including interbody fusion devices, is critical to long-term biomechanical functionality. Mechanical loads are a key regulator of bone tissue remodeling and maintenance, and stress-shielding due to metal orthopaedic implants being much stiffer than bone has been implicated in clinical observations of long-term bone loss in tissue adjacent to implants. Porous features that accommodate bone ingrowth have improved implant fixation in the short term, but long-term retrieval studies have sometimes demonstrated limited, superficial ingrowth into the pore layer of metal implants and aseptic loosening remains a problem for a subset of patients...
January 30, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29413744/an-in%C3%A2-vitro-biomechanical-study-on-ovine-rib-flexibility-with-increasing-deconstruction-as-an-alternative-to-rib-resection-for-costoplasty
#8
Matthew Hughes, Jason Bernard, Matthew Szarko
STUDY DESIGN: An in vitro biomechanical study into the effect of rib deconstruction on the flexibility in ovine ribs, using three-point bending. OBJECTIVE: To examine the feasibility and possible effectiveness of a more conservative costoplasty using an in vitro animal model. SUMMARY OF BACKGROUND DATA: Costoplasty remains useful in the treatment of adolescent idiopathic scoliosis, rib hump, and associated chest wall deformities. However, traditional costoplasty increases morbidity and blood loss...
March 2018: Spine Deformity
https://www.readbyqxmd.com/read/29401469/peri-implant-conditions-and-marginal-bone-loss-around-cemented-and-screw-retained-single-implant-crowns-in-posterior-regions-a-retrospective-cohort-study-with-up-to-4-years-follow-up
#9
Jun-Yu Shi, Jie-Ni, Long-Fei Zhuang, Xiao-Meng Zhang, Lin-Feng Fan, Hong-Chang Lai
The aim of the present study was to identify the peri-implant conditions (bleeding on probing (BOP), pocket probing depth (PPD), modified plaque index (mPI)) and marginal bone loss (MBL, marginal bone level change between follow-up and occlusal loading) around cemented and screw-retained posterior single crowns on tissue-level implants. The study was a retrospective cohort study with up to 4 years (mean 2.5 years) follow-up. Patients with either cemented or screw-retained crowns in posterior regions were included...
2018: PloS One
https://www.readbyqxmd.com/read/29383959/investigation-into-factors-affecting-the-mechanical-behaviours-of-a-patient-specific-vertebral-body-replacement
#10
Ling Wang, Jianfeng Kang, Lei Shi, Jun Fu, Dichen Li, Zheng Guo, Chaozong Liu, Shuangpeng Dong, Xi Jiang
Most vertebral body implants that are currently designed and produced in batches have difficulty meeting the patient-specific demands. Moreover, several complications, including a low fusion rate, subsidence occurrence, and rod displacement, are associated with these implants. This study aims to investigate the effects of patient-specific geometric and clinical parameters on the biomechanics of a vertebral body replacement. A three-dimensional patient-specific vertebral body replacement model was established as the basic model for parametric studies, including the anatomic design of the endplates, tilting angle, thickness, and dislocation of the vertebral body implant...
January 1, 2018: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/29380510/bone-and-soft-tissue-outcomes-risk-factors-and-complications-of-implant-supported-prostheses-5-years-rct-with-different-abutment-types-and-loading-protocols
#11
Catharina Göthberg, Kerstin Gröndahl, Omar Omar, Peter Thomsen, Christer Slotte
BACKGROUND: Data on risk factors and complications after long-term implant treatment is limited. The aims were to evaluate the role of various fixation modes and to analyze complications and risks that affect long-term use of implant-supported partial fixed dental prostheses. MATERIALS AND METHODS: Fifty partially edentulous subjects received three Brånemark TiUnite™ implants. Superstructures were attached directly at implant level (IL) or via abutments: machined surface (AM) and an oxidized surface (AOX, TiUnite™)...
January 30, 2018: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/29379296/initial-peri-and-postoperative-antibiotic-treatment-of-infected-nonunions-results-from-212-consecutive-patients-after-mean-follow-up-of-34-months
#12
Lars Helbig, Maren Bechberger, Riyadh Aldeeri, Adriana Ivanova, Patrick Haubruck, Matthias Miska, Gerhard Schmidmaier, Georg W Omlor
Purpose: Infected nonunions of the long bones belong to the most feared complications in the field of orthopedic and trauma surgery. Optimal antibiotic therapy should start early with the first revision surgery. Therefore, the aim of this study was to evaluate our peri- and postoperative antibiotic regime in context with the microbial spectrum and antibiotic resistances of patients with infected nonunions and to assess the possible impact on healing rates. Methods: We included all patients with first revision surgery during 2010-2015 due to nonunion of long bones with a clinical history of infection treated with radical debridement, local application of a gentamicin-impregnated bone cement, and systemic cefuroxime...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29377338/clinical-effectiveness-of-6-5-mm-long-implants-to-support-two-implant-fixed-prostheses-in-premolar-molar-region-the-influence-of-immediate-loading-and-the-length-of-splinting-implant
#13
Eduardo Anitua, Carlos Flores, Javier Flores, Mohammad Hamdan Alkhraisat
PURPOSE: The purpose of this retrospective clinical study was to assess the influence of immediate loading and lengths of splinted implants on the clinical effectiveness of 6.5-mm-long implants supporting two-implant fixed prostheses in the premolar-molar regions. MATERIALS AND METHODS: A clinical database was reviewed in a private dental center to select those patients who had 6.5-mm-long implants placed to support two-implant fixed partial prostheses in the premolar-molar regions of the maxilla and the mandible...
January 28, 2018: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/29369319/endogenous-sialic-acid-engineered-micelles-a-multifunctional-platform-for-on-demand-methotrexate-delivery-and-bone-repair-of-rheumatoid-arthritis
#14
Xiao-Ling Xu, Wei-Shuo Li, Xiao-Juan Wang, Yang-Long Du, Xu-Qi Kang, Jing-Bo Hu, Shu-Juan Li, Xiao-Ying Ying, Jian You, Yong-Zhong Du
Rheumatoid arthritis (RA) patients have suffered from the current drug therapeutic regimen because of its high toxicity and the absence of bone regeneration for existing erosion, seriously affecting the quality of life. Herein, a sialic acid-dextran-octadecanoic acid (SA-Dex-OA) conjugate was synthesized to form micelles with a 55.06 μg mL-1 critical micelle concentration. The obtained micelles can encapsulate a disease-modifying anti-rheumatic drug, methotrexate (MTX), with 4.28% (w/w) drug content, featuring sustained drug release behavior over 48 h...
January 25, 2018: Nanoscale
https://www.readbyqxmd.com/read/29356963/pathologic-conditions-of-hard-tissue-role-of-osteoclasts-in-osteolytic-lesion
#15
REVIEW
Riko Kitazawa, Ryuma Haraguchi, Mana Fukushima, Sohei Kitazawa
Hard tissue homeostasis is regulated by the balance between bone formation by osteoblasts and bone resorption by osteoclasts. This physiologic process allows adaptation to mechanical loading and calcium homeostasis. Under pathologic conditions, however, this process is ill-balanced resulting in either over-resorption or over-formation of hard tissue. Local over-resorption by osteoclasts is typically observed in osteolytic metastases of malignancies, autoimmune arthritis, and giant cell tumor of bone (GCTB)...
January 22, 2018: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/29355717/localization-and-promotion-of-recombinant-human-bone-morphogenetic-protein-2-bioactivity-on-extracellular-matrix-mimetic-chondroitin-sulfate-functionalized-calcium-phosphate-cement-scaffolds
#16
Baolin Huang, Zihan Wu, Sai Ding, Yuan Yuan, Changsheng Liu
Localization of recombinant human bone morphogenetic protein-2 (rhBMP-2) with continuous and effective osteogenic stimulation is still a great challenge in the field of bone regeneration. To achieve this aim, rhBMP-2 was tethered on chondroitin sulfate (CS)-functionalized calcium phosphate cement (CPC) scaffolds through specific noncovalent interactions. CS, one of the core glycosaminoglycans, was covalently conjugated onto CPC scaffolds with the assistance of polydopamine (PDA) and further immobilized rhBMP-2 in a biomimetic form...
January 17, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29352461/clinical-and-microbiological-evaluation-of-the-effect-of-lactobacillus-reuteri-in-the-treatment-of-mucositis-and-peri-implantitis-a-triple-blind-randomized-clinical-trial
#17
M Galofré, D Palao, M Vicario, J Nart, D Violant
BACKGROUND AND OBJECTIVE: Oral probiotics appear to improve the treatment of periodontal diseases but there is limited evidence on their efficacy in the treatment of peri-implant diseases. The objective of the present study was to evaluate, clinically and microbiologically, the effect of the oral probiotic, Lactobacillus reuteri Prodentis, as adjuvant to non-surgical mechanical therapy in implants with mucositis or peri-implantitis, placed in patients with a history of periodontal disease...
January 19, 2018: Journal of Periodontal Research
https://www.readbyqxmd.com/read/29350089/a-comparative-analysis-of-internal-bone-remodelling-concepts-in-a-novel-implant-for-direct-skeletal-attachment-of-limb-prosthesis-evaluation-a-finite-element-analysis
#18
Piotr Prochor, Eugeniusz Sajewicz
Nowadays, numerous internal bone remodelling concepts are under development, in order to estimate long-term functionality of implants by evaluating the intensity of stress-shielding effect. This effect is also analysed for the implants for direct skeletal attachment, considered as a better exoprosthesis fixation method than prosthetic sockets. Most of bone remodelling approaches are based on basic concepts, differing with certain assumptions, which may affect the accuracy of the results. This article compares commonly used internal bone remodelling concepts and evaluates the functionality of the proposed Limb Prosthesis Osseointegrated Fixation System for direct skeletal attachment of limb prosthesis in comparison with two currently available implants: the Intraosseous Transcutaneous Amputation Prosthesis and the Osseointegrated Prostheses for the Rehabilitation of Amputees...
January 1, 2018: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/29340352/bone-healing-at-functionally-loaded-and-unloaded-screw-shaped-implants-supporting-single-crowns-a-histomorphometric-study-in-humans
#19
Daichi Yonezawa, Adriano Piattelli, Riccardo Favero, Mauro Ferri, Giovanna Iezzi, Daniele Botticelli
PURPOSE: To evaluate histologically and histomorphometrically the effect of a delayed load on healing at implants with a moderately rough surface. MATERIALS AND METHODS: Two solid titanium screw-shaped devices, 5 mm long and 3.5 mm in diameter, were inserted in the distal segments of the alveolar ridge of 16 volunteer patients in a nonsubmerged fashion. After 2 months, one implant was loaded, while the other was left unloaded. After 2 months, the two implants were collected from 10 patients using a sonic instrument, and ground sections were prepared from the biopsy specimens...
January 2018: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/29322335/mechanobiological-modeling-of-endochondral-ossification-an-experimental-and-computational-analysis
#20
J J Vaca-González, M Moncayo-Donoso, J M Guevara, Y Hata, S J Shefelbine, D A Garzón-Alvarado
Long bone formation starts early during embryonic development through a process known as endochondral ossification. This is a highly regulated mechanism that involves several mechanical and biochemical factors. Because long bone development is an extremely complex process, it is unclear how biochemical regulation is affected when dynamic loads are applied, and also how the combination of mechanical and biochemical factors affect the shape acquired by the bone during early development. In this study, we develop a mechanobiological model combining: (1) a reaction-diffusion system to describe the biochemical process and (2) a poroelastic model to determine the stresses and fluid flow due to loading...
January 10, 2018: Biomechanics and Modeling in Mechanobiology
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