keyword
MENU ▼
Read by QxMD icon Read
search

Loading on long bones

keyword
https://www.readbyqxmd.com/read/28327697/seven-mm-long-dental-implants-in-posterior-jaws-3-year-report-of-an-ongoing-prospective-single-cohort-study
#1
Paulo Maló, Miguel de Araújo Nobre, Armando Lopes, Inês Gonçalves, Mariana Nunes
PURPOSE: To report on the outcome of 7 mm long implants in the rehabilitation of posterior areas of atrophic jaws 3 years after loading. MATERIALS AND METHODS: This prospective study included 127 patients treated with 217 implants supporting 165 fixed prostheses. Final abutments were delivered at surgery stage and in the large majority of patients (n = 116) the implants (n = 199) were loaded after 4 months. Primary outcome measures were implant success and prosthetic success calculated at patient level; secondary outcome measures were complications, and marginal bone level changes calculated at patient level...
2017: European Journal of Oral Implantology
https://www.readbyqxmd.com/read/28297183/ontogeny-of-the-human-pelvis
#2
Stefaan W Verbruggen, Niamh C Nowlan
The human pelvis has evolved over time into a remarkable structure, optimised into an intricate architecture that transfers the entire load of the upper body into the lower limbs, while also facilitating bipedal movement. The pelvic girdle is composed of two hip bones, os coxae, themselves each formed from the gradual fusion of the ischium, ilium and pubis bones. Unlike the development of the classical long bones, a complex timeline of events must occur in order for the pelvis to arise from the embryonic limb buds...
April 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/28283180/does-intra-articular-load-distribution-change-after-lateral-malleolar-fractures-an-in-vivo-study-comparing-operative-and-non-operative-treatment
#3
Christian Deml, Martin Eichinger, Wouter F van Leeuwen, Stefanie Erhart, Simon A Euler, Alexander Brunner
PURPOSE: The impact of isolated malleolar fractures on the intra-articular load distribution within the ankle joint has been studied in several biomechanical cadaver studies during the last decades. Recently, computed tomography osteoabsorptiometry (CT-OAM) has been proposed as a valuable tool to assess intra-articular joint load distribution in vivo. The purpose of this retrospective matched pair analysis was to apply CT-OAM to evaluate in vivo changes of talar load distribution after lateral malleolar fractures in patients treated with open anatomic reduction and internal fixation (ORIF) compared to patients treated non-operatively...
March 6, 2017: Injury
https://www.readbyqxmd.com/read/28257884/development-of-advanced-biantibiotic-loaded-bone-cement-spacers-for-arthroplasty-associated-infections
#4
F J Parra-Ruíz, A González-Gómez, M Fernández-Gutiérrez, J Parra, J García-García, G Azuara, B De la Torre, J Buján, B Ibarra, L Duocastella-Codina, M Molina-Crisol, B Vázquez-Lasa, J San Román
The incidence increase of infections in patients with hip or knee implants with resistant pathogens (mainly some S. coagulase-negative and gram positive bacteria) demands advanced antibiotic loaded formulations. In this paper, we report the design of new biantibiotic acrylic bone cements for in situ delivery. They include a last generation antibiotic (daptomycin or linezolid) in combination with vancomycin and are performed based on a novel modification of the Palacos R(®) acrylic bone cement, which is based on two components, a liquid (methyl methacrylate) and a solid (polymeric phase)...
February 28, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28256244/oscillatory-fluid-flow-induces-the-osteogenic-lineage-commitment-of-mesenchymal-stem-cells-the-effect-of-shear-stress-magnitude-frequency-and-duration
#5
Elena Stavenschi, Marie-Noelle Labour, David A Hoey
A potent regulator of bone anabolism is physical loading. However, it is currently unclear whether physical stimuli such as fluid shear within the marrow cavity is sufficient to directly drive the osteogenic lineage commitment of resident mesenchymal stem cells (MSC). Therefore, the objective of the study is to employ a systematic analysis of oscillatory fluid flow (OFF) parameters predicted to occur in vivo on early MSC osteogenic responses and late stage lineage commitment. MSCs were exposed to OFF of 1Pa, 2Pa and 5Pa magnitudes at frequencies of 0...
February 21, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28246928/raloxifene-improves-bone-mechanical-properties-in-mice-previously-treated-with-zoledronate
#6
Cory N Meixner, Mohammad W Aref, Aryaman Gupta, Erin M B McNerny, Drew Brown, Joseph M Wallace, Matthew R Allen
Bisphosphonates represent the gold-standard pharmaceutical agent for reducing fracture risk. Long-term treatment with bisphosphonates can result in tissue brittleness which in rare clinical cases manifests as atypical femoral fracture. Although this has led to an increasing call for bisphosphonate cessation, few studies have investigated therapeutic options for follow-up treatment. The goal of this study was to test the hypothesis that treatment with raloxifene, a drug that has cell-independent effects on bone mechanical material properties, could reverse the compromised mechanical properties that occur following zoledronate treatment...
February 28, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28240268/fabrication-and-in-vitro-biological-properties-of-piezoelectric-bioceramics-for-bone-regeneration
#7
Yufei Tang, Cong Wu, Zixiang Wu, Long Hu, Wei Zhang, Kang Zhao
The piezoelectric effect of biological piezoelectric materials promotes bone growth. However, the material should be subjected to stress before it can produce an electric charge that promotes bone repair and reconstruction conducive to fracture healing. A novel method for in vitro experimentation of biological piezoelectric materials with physiological load is presented. A dynamic loading device that can simulate the force of human motion and provide periodic load to piezoelectric materials when co-cultured with cells was designed to obtain a realistic expression of piezoelectric effect on bone repair...
February 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28212706/sclerostin-antibody-inhibits-skeletal-deterioration-in-mice-exposed-to-partial-weight-bearing
#8
J M Spatz, R Ellman, A M Cloutier, L Louis, M van Vliet, D Dwyer, M Stolina, H Z Ke, M L Bouxsein
Whereas much is known regarding the musculoskeletal responses to full unloading, little is known about the physiological effects and response to pharmacological agents in partial unloading (e.g. Moon and Mars) environments. To address this, we used a previously developed ground-based model of partial weight-bearing (PWB) that allows chronic exposure to reduced weight-bearing in mice to determine the effects of murine sclerostin antibody (SclAbII) on bone microstructure and strength across different levels of mechanical unloading...
February 2017: Life Sciences in Space Research
https://www.readbyqxmd.com/read/28205407/collagen-fiber-orientation-in-primate-long-bones
#9
Johanna Warshaw, Timothy G Bromage, Carl J Terranova, Donald H Enlow
Studies of variation in orientation of collagen fibers within bone have lead to the proposition that these are preferentially aligned to accommodate different kinds of load, with tension best resisted by fibers aligned longitudinally relative to the load, and compression best resisted by transversely aligned fibers. However, previous studies have often neglected to consider the effect of developmental processes, including constraints on collagen fiber orientation (CFO), particularly in primary bone. Here we use circularly polarized light microscopy to examine patterns of CFO in cross-sections from the midshaft femur, humerus, tibia, radius and ulna in a range of living primate taxa with varied body sizes, phylogenetic relationships and positional behaviors...
February 16, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/28196619/development-and-verification-of-novel-porous-titanium-metaphyseal-cones-for-revision-total-knee-arthroplasty
#10
Ahmad Faizan, Manoshi Bhowmik-Stoker, Amanda E Kirk, Viktor E Krebs, Steven F Harwin, R Michael Meneghini
BACKGROUND: Porous metaphyseal cones are widely used in revision knee arthroplasty. A new system of porous titanium metaphyseal cones has been designed based on the femoral and tibial morphology derived from a computed tomography-based anatomical database. The purpose of this study is to evaluate the initial mechanical stability of the new porous titanium revision cone system by measuring the micromotion under physiologic loading compared with a widely-used existing porous tantalum metaphyseal cone system...
January 18, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28182119/biodegradable-mesoporous-delivery-system-for-biomineralization-precursors
#11
Hong-Ye Yang, Li-Na Niu, Jin-Long Sun, Xue-Qing Huang, Dan-Dan Pei, Cui Huang, Franklin R Tay
Scaffold supplements such as nanoparticles, components of the extracellular matrix, or growth factors have been incorporated in conventional scaffold materials to produce smart scaffolds for tissue engineering of damaged hard tissues. Due to increasing concerns on the clinical side effects of using large doses of recombinant bone-morphogenetic protein-2 in bone surgery, it is desirable to develop an alternative nanoscale scaffold supplement that is not only osteoinductive, but is also multifunctional in that it can perform other significant bone regenerative roles apart from stimulation of osteogenic differentiation...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28181688/dental-implants-and-bone-augmentation-in-hiv-infected-patients-under-haart-case-report-and-review-of-the-literature
#12
Fábio Vidal, Rafael Vidal, Jeter Bochnia, Rodrigo Carvalho de Souza, Lucio Souza Gonçalves
The present study reviewed the literature regarding dental implants in HIV-infected patients and reports the long-term follow-up of three clinical cases of patients under HAART that received bone augmentation and dental implants. The first case presents a young patient with a large defect in the mandible, as a consequence of a longitudinal fracture, that was treated with guided bone regeneration (GBR) previously to implant placement. The second case reported is middle-aged man with a fractured upper lateral incisor treated with immediate placement and simultaneous GBR to repair the dehiscence due to the buccal bone resorption...
February 9, 2017: Special Care in Dentistry
https://www.readbyqxmd.com/read/28154923/the-effect-of-impact-tool-geometry-and-soft-material-covering-on-long-bone-fracture-patterns-in-children
#13
Haim Cohen, Chen Kugel, Hila May, Bahaa Medlej, Dan Stein, Viviane Slon, Tamar Brosh, Israel Hershkovitz
INTRODUCTION: The effect of impact tool geometry and soft material covering on bone fracture patterns plays a major role in fracture patterns. However, the literature is nearly void of such studies and only general correlations between the fracture pattern and the mechanism underlying the insult were reported. PURPOSE: The aim of this study is to reveal the association between the geometry of the impact tool and the presence of soft material covering on bone fracture patterns...
February 2, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28144820/a-preclinical-numerical-assessment-of-a-polyetheretherketone-femoral-component-in-total-knee-arthroplasty-during-gait
#14
Lennert de Ruiter, Dennis Janssen, Adam Briscoe, Nico Verdonschot
BACKGROUND: Conventional total knee replacement designs show high success rates but in the long term, the stiff metal components may affect bone quality of the distal femur. In this study we introduce an all-polymer total knee replacement device containing a PEEK femoral component on an UHMWPE tibial implant and study its mechanical integrity, fixation, and stress shielding of the periprosthetic femur. METHODS: The implant was analysed in finite element simulations of level gait, adopted from the ISO 14243-1 standard...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28132525/influence-of-custom-made-implant-designs-on-the-biomechanical-performance-for-the-case-of-immediate-post-extraction-placement-in-the-maxillary-esthetic-zone-a-finite-element-analysis
#15
Jianyu Chen, Zhiguang Zhang, Xianshuai Chen, Xiao Zhang
Due to the increasing adoption of immediate implantation strategies and the rapid development of the computer aided design/computer aided manufacturing technology, a therapeutic concept based on patient-specific implant dentistry has recently been reintroduced by many researchers. However, little information is available on the designs of custom-made dental implant systems, especially their biomechanical behavior. The influence of the custom-made implant designs on the biomechanical performance for both an immediate and a delayed loading protocol in the maxillary esthetic zone was evaluated by means of the finite element (FE) method...
January 29, 2017: Computer Methods in Biomechanics and Biomedical Engineering
https://www.readbyqxmd.com/read/28128919/carbon-nanofiber-polycaprolactone-mineralized-hydroxyapatite-nanofibrous-scaffolds-for-potential-orthopedic-applications
#16
Shinyjoy Elangomannan, Kavitha Louis, Bhagya Mathi Dharmaraj, Venkata Saravanan Kandasamy, Kannan Soundarapandian, Dhanaraj Gopi
Hydroxyapatite (Ca10 (PO4)6(OH)2, HAP), a multimineral substituted calcium phosphate is one of the most substantial bone mineral component that has been widely used as bone replacement materials because of its bioactive and biocompatible properties. However, the use of HAP as bone implants is restricted due to its brittle nature and poor mechanical properties. To overcome this defect and to generate suitable bone implant material, HAP is combined with biodegradable polymer (polycaprolactone, PCL). To enhance the mechanical property of the composite, carbon nanofibers (CNF) is incorporated to the composite, which has long been considered for hard and soft tissue implant due to its exceptional mechanical and structural properties...
February 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28128420/grk2-desensitizes-flow-induced-responses-in-osteoblasts
#17
Y Xing, Y Gu, X Shan, L Wang, J You
Bone desensitization after mechanical loading is essential for bone to adapt to its mechanical environment. However, the desensitization mechanism is unknown. Previous studies suggest that G protein-coupled receptors (GPCRs), including P2Y and parathyroid hormone receptors, play important roles in osteoblast mechanobiology. Thus, for the present research, we examined the role of G protein-coupled receptor kinase 2 (GRK2) in osteoblast desensitization after exposure to mechanical stimulation. We first showed the existence of osteoblast desensitization after mechanical stimulation based on cytosol Ca(2+) and phosphorylated ERK1/2 activities, detected using a fluorescent Ca(2+)-sensitive dye and western blotting, respectively...
January 23, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28124077/long-term-treatment-effects-in-chronic-myeloid-leukemia
#18
Apollos Besse, Thomas Lepoutre, Samuel Bernard
We propose and analyze a simplified version of a partial differential equation (PDE) model for chronic myeloid leukemia (CML) derived from an agent-based model proposed by Roeder et al. This model describes the proliferation and differentiation of leukemic stem cells in the bone marrow and the effect of the drug Imatinib on these cells. We first simplify the PDE model by noting that most of the dynamics occurs in a subspace of the original 2D state space. Then we determine the dominant eigenvalue of the corresponding linearized system that controls the long-term behavior of solutions...
January 25, 2017: Journal of Mathematical Biology
https://www.readbyqxmd.com/read/28109795/bone-morphological-effects-on-post-implantation-remodeling-of-maxillary-anterior-buccal-bone-a-clinical-and-biomechanical-study
#19
Nobuhiro Yoda, Keke Zheng, Junning Chen, Wei Li, Michael Swain, Keiichi Sasaki, Qing Li
PURPOSE: This study combines clinical investigation with finite element (FE) analysis to explore the effects of buccal bone thickness (BBT) on the morphological changes of buccal bone induced by the loaded implant. METHODS: One specific patient who had undergone an implant treatment in the anterior maxilla and experienced the buccal bone resorption on the implant was studied. Morphological changes of the bone were measured through a series of cone-beam computed tomography (CT) scans...
January 18, 2017: Journal of Prosthodontic Research
https://www.readbyqxmd.com/read/28109138/adaptations-in-the-microarchitecture-and-load-distribution-of-maternal-cortical-and-trabecular-bone-in-response-to-multiple-reproductive-cycles-in-rats
#20
Chantal Mj de Bakker, Allison R Altman-Singles, Yihan Li, Wei-Ju Tseng, Connie Li, X Sherry Liu
Pregnancy, lactation, and weaning result in dramatic changes in maternal calcium metabolism. In particular, the increased calcium demand during lactation causes a substantial degree of maternal bone loss. This reproductive bone loss has been suggested to be largely reversible, as multiple clinical studies have found that parity and lactation history have no adverse effect on postmenopausal fracture risk. However, the precise effects of pregnancy, lactation, and post-weaning recovery on maternal bone structure are not well understood...
January 21, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
keyword
keyword
32793
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"