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https://www.readbyqxmd.com/read/28533009/comparison-of-implant-stability-measurement-devices-for-bone-anchored-hearing-aid-systems
#1
Lindsey Westover, Gary Faulkner, William Hodgetts, Don Raboud
STATEMENT OF PROBLEM: The success of implants for bone-anchored hearing aids (BAHA) relies on proper osseointegration at the bone-implant interface. Clinical evaluation of implant stability is important in prescribing loading, identifying the risk of failure, and monitoring the long-term health of the implant. PURPOSE: The purpose of this in vitro study was to evaluate 2 measurement systems for BAHA implant stability: the most commonly used, Osstell implant stability quotient (ISQ), and a newly developed advance system for implant stability testing (ASIST)...
May 20, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28532663/recent-developments-in-drug-eluting-devices-with-tailored-interfacial-properties
#2
REVIEW
Eva Sanchez-Rexach, Emilio Meaurio, Jose-Ramon Sarasua
Drug eluting devices have greatly evolved during past years to become fundamental products of great marketing importance in the biomedical field. There is currently a large diversity of highly specialized devices for specific applications, making the development of these devices an exciting field of research. The replacement of the former bare metal devices by devices loaded with drugs allowed the sustained and controlled release of drugs, to achieve the desired local therapeutic concentration of drug. The newer devices have been "engineered" with surfaces containing micro- and nanoscale features in a well-controlled manner, that have shown to significantly affect cellular and subcellular function of various biological systems...
May 4, 2017: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/28532049/co-delivery-of-cisplatin-and-doxorubicin-from-calcium-phosphate-beads-matrix-scaffolds-for-osteosarcoma-therapy
#3
Ulrike Hess, Shakiba Shahabi, Laura Treccani, Philipp Streckbein, Christian Heiss, Kurosch Rezwan
Bone substitute materials with a controlled drug release ability can fill cavities caused by the resection of bone tumours and thereby combat any leftover bone cancer cells. The combined release of different cytostatics seems to enhance their toxicity. In this study, calcium phosphate beads and matrix scaffolds are combined for a long-term co-delivery of cis-diamminedichloroplatinum (cisplatin, CDDP) and doxorubicin hydrochloride (DOX) as clinical relevant model drugs. Tricalcium phosphate/alginate beads as additional drug carrier are produced by droplet extrusion with ionotropic gelation and incorporated in scaffold matrix by freeze gelation without sintering...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28529864/allograft-bone-as-antibiotic-carrier
#4
REVIEW
Heinz Winkler, Peter Haiden
The treatment of chronic bone and joint infections is characterized by obstinate persistency of the causing microorganisms and resulting long term disability to patients, associated with remarkable costs for the health care system. Difficulties derive from biofilm formed on dead bone and eventual implants, with resistance against immunological defences and antimicrobial substances. Biofilm embedded bacteria require up to 1000 times the antibiotic concentration of planktonic bacteria for elimination. Systemic antibiotic treatment alone cannot provide the concentrations required and surgical intervention is always prerequisite for potentially providing a cure...
2017: J Bone Jt Infect
https://www.readbyqxmd.com/read/28508006/early-osteoarthritis-after-untreated-anterior-meniscal-root-tears-an-in-vivo-animal-study
#5
Brett D Steineman, Robert F LaPrade, Kelly S Santangelo, Brent T Warner, Laurie R Goodrich, Tammy L Haut Donahue
BACKGROUND: Meniscal root tears cause menisci and their insertions to inadequately distribute loads and potentially leave underlying articular cartilage unprotected. Untreated meniscal root tears are becoming increasingly recognized to induce joint degradation; however, little information is known about anterior meniscal root tears and how they affect joint tissue. PURPOSE: To observe the early degenerative changes within the synovial fluid, menisci, tibial articular cartilage, and subchondral bone after arthroscopic creation of untreated anterior meniscal root tears...
April 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28495397/safety-profile-and-long-term-engraftment-of-human-cd31-blood-progenitors-in-bone-tissue-engineering
#6
Hadar Zigdon-Giladi, Rina Elimelech, Gal Michaeli-Geller, Utai Rudich, Eli E Machtei
BACKGROUND: Endothelial progenitor cells (EPCs) participate in angiogenesis and induce favorable micro-environments for tissue regeneration. The efficacy of EPCs in regenerative medicine is extensively studied; however, their safety profile remains unknown. Therefore, our aims were to evaluate the safety profile of human peripheral blood-derived EPCs (hEPCs) and to assess the long-term efficacy of hEPCs in bone tissue engineering. METHODS: hEPCs were isolated from peripheral blood, cultured and characterized...
May 8, 2017: Cytotherapy
https://www.readbyqxmd.com/read/28493384/risk-factors-for-single-crowns-supported-by-short-6-mm-implants-in-the-posterior-region-a-prospective-clinical-and-radiographic-study
#7
Eduardo Aydos Villarinho, Diego Fernandes Triches, Fernando Rizzo Alonso, Luis André Mendonça Mezzomo, Eduardo Rolim Teixeira, Rosemary Sadami Arai Shinkai
BACKGROUND: The use of short implants is still not a consensus for challenging clinical situations, such as unfavorable crown-to-implant (C/I) ratio. PURPOSE: This prospective study evaluated the rates of prosthetic complications and implant failure, the mean marginal bone loss of 6-mm dental implants with single crowns in posterior regions and the potential risk factors. MATERIALS AND METHODS: Forty-six dental implants, 6-mm long and 4.1-mm wide, were placed in the posterior region in 20 patients...
May 10, 2017: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/28486958/exosomes-as-potential-alternatives-to-stem-cell-therapy-for-intervertebral-disc-degeneration-in-vitro-study-on-exosomes-in-interaction-of-nucleus-pulposus-cells-and-bone-marrow-mesenchymal-stem-cells
#8
Kang Lu, Hai-Yin Li, Kuang Yang, Jun-Long Wu, Xiao-Wei Cai, Yue Zhou, Chang-Qing Li
BACKGROUND: The stem cell-based therapies for intervertebral disc degeneration have been widely studied. However, the mechanisms of mesenchymal stem cells interacting with intervertebral disc cells, such as nucleus pulposus cells (NPCs), remain unknown. Exosomes as a vital paracrine mechanism in cell-cell communication have been highly focused on. The purpose of this study was to detect the role of exosomes derived from bone marrow mesenchymal stem cells (BM-MSCs) and NPCs in their interaction with corresponding cells...
May 10, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28481781/bone-anchored-hearing-implant-surgery-1-year-follow-up-data-shows-no-effect-of-hydroxyapatite-coating-on-soft-tissue-reaction-after-loading-at-1-week
#9
Morten Høgsbro, Andreas Agger, Lars Vendelbo Johansen
OBJECTIVE: To assess postoperative skin complications around a bone anchored hearing implant (BAHI) abutment coated with hydroxyapatite and loaded after 1 week. DESIGN: Single center, prospective cohort study of 25 adults with expected normal skin and bone quality. INTERVENTION: Implantation of the Baha BA400 hydroxyapatite coated implant system using a linear incision technique without soft tissue reduction. Abutments with lengths of 8 mm (n = 9), 10 mm (n = 11), and 12 mm (n = 5) were used...
May 5, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28481082/hydroxyapatite-nanowire-magnesium-silicate-core-shell-hierarchical-nanocomposite-synthesis-and-application-in-bone-regeneration
#10
Tuan-Wei Sun, Wei-Lin Yu, Ying-Jie Zhu, Ri-Long Yang, Yue-Qin Shen, Dao-Yun Chen, Yao-Hua He, Feng Chen
Multifunctional biomaterials that simultaneously combine high biocompatibility, biodegradability, and bioactivity are promising for applications in various biomedical fields such as bone defect repair and drug delivery. Herein, the synthesis of hydroxyapatite nanowire@magnesium silicate nanosheets (HANW@MS) core-shell porous hierarchical nanocomposites (nanobrushes) is reported. The morphology of the magnesium silicate (MS) shell can be controlled by simply varying the solvothermal temperature and the amount of Mg(2+) ions...
May 8, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28473698/implantable-strain-sensor-to-monitor-fracture-healing-with-standard-radiography
#11
Hunter Pelham, Donald Benza, Paul W Millhouse, Nathan Carrington, Md Arifuzzaman, Caleb J Behrend, Jeffrey N Anker, John D DesJardins
Current orthopaedic clinical methods do not provide an objective measure of fracture healing or weight bearing for lower extremity fractures. The following report describes a novel approach involving in-situ strain sensors to objectively measure fracture healing. The sensor uses a cantilevered indicator pin that responds to plate bending and an internal scale to demonstrate changes in the pin position on plain film radiographs. The long lever arm amplifies pin movement compared to interfragmentary motion, and the scale enables more accurate measurement of position changes...
May 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28466248/comparative-evaluation-of-the-stability-of-two-different-dental-implant-designs-and-surgical-protocols-a-pilot-study
#12
David E Simmons, Pooja Maney, Austin G Teitelbaum, Susan Billiot, Lomesh J Popat, A Archontia Palaiologou
BACKGROUND: The purpose of this study was to compare a parallel wall design implant to a tapered apex design implant when placed in the posterior maxilla using two different surgical protocols. METHODS: Twenty-seven patients (30 implants) were divided into three groups. All implants were 4 mm wide in diameter and 8 mm long. Group A received 10 tapered implants (OSPTX) (Astra Tech OsseoSpeed TX™) using the soft bone surgical protocol (TXSoft). Group B received 10 tapered implants (OSPTX) (AstraTech OsseoSpeedTX™) using the standard surgical protocol (TXStd)...
December 2017: International Journal of Implant Dentistry
https://www.readbyqxmd.com/read/28457207/early-and-marked-enhancement-of-new-bone-quality-by-alendronate-loaded-collagen-sponge-combined-with-bone-morphogenetic-protein-2-at-high-dose-a-long-term-study-in-calvarial-defects-in-a-rat-model
#13
Tae Hyung Cho, In Sook Kim, Beomseok Lee, Si-Nae Park, Jae-Hyung Ko, Soon Jung Hwang
Choice of appropriate biomaterial is a key factor for the success of recombinant human bone morphogenetic protein (rhBMP)-2 therapy. Inspired by the osteogenic cell differentiating and osteoclast suppressing capabilities of alendronate (ALN), we manufactured a composite type of ALN-loaded collagen sponge (ALN-CS) which controls the early detrimental effect of high-dose rhBMP-2. This study aimed to evaluate ALN-CS as a high-dose rhBMP-2 carrier by investigating its initial bio-molecular effect and efficacy on intramembranous ossification at 1, 4, 8 and 24 weeks using a rat calvarial defect model, compared with non-loaded CS...
April 29, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28453221/peri-implant-bone-density-around-implants-of-different-lengths-a-3-year-follow-up-of-a-randomized-clinical-trial
#14
P Sahrmann, P Schoen, N Naenni, R Jung, T Attin, P R Schmidlin
OBJECTIVES: Short dental implants are frequently placed, however, little is known about the effect of the loading force regarding an enhanced crown-to-implant ratio. The aim of this study was therefore to assess bone density changes after a three-year period, on radiographs acquired from a randomized controlled two-center clinical study comparing implants of 6 and 10 mm of length. MATERIALS AND METHODS: Three predefined areas were chosen on standardized X-rays in order to assess grey-scale values of the peri-implant bone: One at the tip of the apex and two at half-length on the mesial and distal sides of the implant...
April 28, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28451863/variations-in-knee-kinematics-after-acl-injury-and-after-reconstruction-are-correlated-with-bone-shape-differences
#15
Drew A Lansdown, Valentina Pedoia, Musa Zaid, Keiko Amano, Richard B Souza, Xiaojuan Li, C Benjamin Ma
BACKGROUND: The factors that contribute to the abnormal knee kinematics after anterior cruciate ligament (ACL) injury and ACL reconstruction remain unclear. Bone shape has been implicated in the development of hip and knee osteoarthritis, although there is little knowledge about the effects of bone shape on knee kinematics after ACL injury and after ACL reconstruction. QUESTIONS/QUESTIONS: (1) What is the relationship between bony morphology with alterations in knee kinematics after ACL injury? (2) Are baseline bone shape features related to abnormal knee kinematics at 12 months after ACL reconstruction? METHODS: Thirty-eight patients (29 ± 8 years, 21 men) were prospectively followed after acute ACL injury and before ligamentous reconstruction...
April 27, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28439058/-calcium-and-bone-metabolism-across-women-s-life-stages-stress-fracture-in-female-athletes
#16
Kazuyoshi Yagishita
Stress fractures are common overuse injuries in athletes, especially in long-distance runner, jumping sports and gymnastics in female athletes. The pathology of stress fracture mainly includes repeated biomechanical loading, which leads to bone micro-damage and failure of bone structure. Female athlete triad(FAT), which includes low energy availability with or without an eating disorder, functional hypothalamic amenorrhea, and osteoporosis, is a serious healthcare concern in female athletes. For prevention and treatment of stress fracture, management of biomechanical factors modifying the load applied to a bone is important, and especially in female athletes, management for FAT is one of the important factors...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28433242/freeform-extrusion-fabrication-of-titanium-fiber-reinforced-13-93-bioactive-glass-scaffolds
#17
Albin Thomas, Krishna C R Kolan, Ming C Leu, Gregory E Hilmas
Although implants made with bioactive glass have shown promising results for bone repair, their application in repairing load-bearing long bone is limited due to their poor mechanical properties in comparison to human bone. This work investigates the freeform extrusion fabrication of bioactive silicate 13-93 glass scaffolds reinforced with titanium (Ti) fibers. A composite paste prepared with 13-93 glass and Ti fibers (~16µm in diameter and lengths varying from ~200µm to ~2 mm) was extruded through a nozzle to fabricate scaffolds (0-90° filament orientation pattern) on a heated plate...
June 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28414986/modelling-dental-implant-extraction-by-pullout-and-torque-procedures
#18
D Rittel, A Dorogoy, K Shemtov-Yona
Dental implants extraction, achieved either by applying torque or pullout force, is used to estimate the bone-implant interfacial strength. A detailed description of the mechanical and physical aspects of the extraction process in the literature is still missing. This paper presents 3D nonlinear dynamic finite element simulations of a commercial implant extraction process from the mandible bone. Emphasis is put on the typical load-displacement and torque-angle relationships for various types of cortical and trabecular bone strengths...
April 11, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28402219/modified-n-ha-pa66-scaffolds-with-chitosan-coating-for-bone-tissue-engineering-cell-stimulation-and-drug-release
#19
Qin Zou, Junfeng Li, Lulu Niu, Yi Zuo, Jidong Li, Yubao Li
The dipping-drying procedure and cross-linking method were used to make drug-loaded chitosan(CS) coating on nano-hydroxyapatite/polyamide66 (nHA/PA66) composite porous scaffold, endowing the scaffold controlled drug release functionality. The prefabricated scaffold was immersed into an aqueous drug/CS solution in a vacuum condition and then crosslinked by vanillin. The structure, porosity, composition, compressive strength, swelling ratio, drug release and cytocompatibility of the pristine and coating scaffolds were investigated...
April 12, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28401593/low-dose-bmp-2-and-msc-dual-delivery-onto-coral-scaffold-for-critical-size-bone-defect-regeneration-in-sheep
#20
Adeline Decambron, Alexandre Fournet, Morad Bensidhoum, Mathieu Manassero, Frédéric Sailhan, Hervé Petite, Delphine Logeart-Avramoglou, Véronique Viateau
Tissue-engineered constructs (TECs) combining resorbable calcium-based scaffolds and mesenchymal stem cells (MSCs) have the capability to regenerate large bone defects. Inconsistent results have, however, been observed, with a lack of osteoinductivity as a possible cause of failure. This study aimed to evaluate the impact of the addition of low-dose bone morphogenetic protein-2 (BMP-2) to MSC-coral-TECs on the healing of clinically-relevant segmental bone defects in sheep. Coral granules were either seeded with autologous MSCs (bone marrow-derived) or loaded with BMP-2...
April 12, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
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