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https://www.readbyqxmd.com/read/28795294/how-long-does-antimycobacterial-antibiotic-loaded-bone-cement-have-in-vitro-activity-for-musculoskeletal-tuberculosis
#1
Jae Hoo Lee, Chang Dong Han, Sang-Nae Cho, Ick Hwan Yang, Woo Suk Lee, Seung-Hun Baek, Jae Won Shin, Khalid Elfadil Ibrahim Husein, Kwan Kyu Park
BACKGROUND: Antibiotic-loaded bone cement is accepted as an effective treatment modality for musculoskeletal tuberculosis. However, comparative information regarding combinations and concentrations of second-line antimycobacterial drugs, such as streptomycin and amoxicillin and clavulanic acid, are lacking. QUESTIONS/PURPOSES: (1) In antibiotic-loaded cement, is there effective elution of streptomycin and Augmentin(®) (amoxicillin and clavulanic acid) individually and in combination? (2) What is the antibacterial activity duration for streptomycin- and amoxicillin and clavulanic acid -loaded cement? METHODS: Six different types of bone cement discs were created by mixing 40 g bone cement with 1 or 2 g streptomycin only, 0...
August 9, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28789651/effect-of-athletic-fatigue-damage-and-the-associated-bone-targeted-remodeling-in-the-rat-ulna
#2
Li Hao, Li Rui-Xin, Han Biao, Zhao Bin, Hao Bao-Hui, Liu Ying-Jie, Zhang Xi-Zheng
BACKGROUND: Fatigue damage of the long bones is prevalent in running athletes and military recruits due to vigorous mid- and long-term physical activity. The current study attempted to know the features of bony athletic fatigue damage and to explore the mechanism of fatigue damage repair through bone targeted remodeling process. METHODS: Right ulnae of the Wistar rats were fatigue loaded on an INSTRON 5865 to construct the athletic fatigue damage model, and several time points (i...
August 8, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28775205/therapy-related-hematological-malignancies-after-peptide-receptor-radionuclide-therapy-with-177-lu-dota-octreotate-incidence-course-predicting-factors-in-patients-with-gep-nets
#3
Hendrik Bergsma, Kirsten van Lom, Mark Konijnenberg, Boen Kam, Jaap Teunissen, Wouter de Herder, Eric Krenning, Dik Kwekkeboom
Peptide Receptor Radionuclide Therapy (PRRT) may induce long-term toxicity to the bone marrow (BM). The aim of this study was to analyze persistent dysfunction of the hematopoietic system after PRRT with (177)Lu-DOTATATE in patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs). Methods: The incidence and course of persistent hematological dysfunction (PHD) was analyzed in 274 (=GEP-NET) out of 367 patients with somatostatin receptor-positive tumors. PHD was defined as diagnosis of Myelodysplastic Syndrome (MDS), Acute Myeloid Leukemia (AML), Myeloproliferative Neoplasms (MPN), Myelodysplastic/Myeloproliferative neoplasms (MDS/MPN) or otherwise unexplained cytopenia (for more than 6 months)...
August 3, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28771373/biomechanical-evaluation-of-glenoid-reconstruction-with-an-implant-free-j-bone-graft-for-anterior-glenoid-bone-loss
#4
Leo Pauzenberger, Felix Dyrna, Elifho Obopilwe, Philipp R Heuberer, Robert A Arciero, Werner Anderl, Augustus D Mazzocca
BACKGROUND: The anatomic restoration of glenoid morphology with an implant-free J-shaped iliac crest bone graft offers an alternative to currently widely used glenoid reconstruction techniques. No biomechanical data on the J-bone grafting technique are currently available. PURPOSE: To evaluate (1) glenohumeral contact patterns, (2) graft fixation under cyclic loading, and (3) the initial stabilizing effect of anatomic glenoid reconstruction with the implant-free J-bone grafting technique...
August 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28759839/characterization-of-the-bone-metal-implant-interface-by-digital-volume-correlation-of-in-situ-loading-using-neutron-tomography
#5
Sophie Le Cann, Erika Tudisco, Christina Perdikouri, Ola Belfrage, Anders Kaestner, Stephen Hall, Magnus Tägil, Hanna Isaksson
Metallic implants are commonly used as surgical treatments for many orthopedic conditions. The long-term stability of implants relies on an adequate integration with the surrounding bone. Unsuccessful integration could lead to implant loosening. By combining mechanical loading with high-resolution 3D imaging methods, followed by image analysis such as Digital Volume Correlation (DVC), we aim at evaluating ex vivo the mechanical resistance of newly formed bone at the interface. X-rays tomography is commonly used to image bone but induces artefacts close to metallic components...
July 1, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28708909/biomechanical-three-dimensional-finite-element-analysis-of-single-implant-supported-prostheses-in-the-anterior-maxilla-with-different-surgical-techniques-and-implant-types
#6
Fellippo Ramos Verri, Joel Ferreira Santiago, Daniel Augusto Almeida, Victor Eduardo de Souza Batista, Cleidiel Aparecido Araujo Lemos, Caroline Cantieri Mello, Eduardo Piza Pellizzer
PURPOSE: The aim of this study was to use three-dimensional finite element analysis to analyze the stress distribution transferred by single implant-supported prostheses placed in the anterior maxilla using different connections (external hexagon, internal hexagon, or Morse taper), inclinations of the load (0, 30, or 60 degrees), and surgical techniques for placement (monocortical/conventional, bicortical, or bicortical with nasal floor elevation). MATERIALS AND METHODS: Nine models representing a bone block of this region were simulated by computer-aided design software (InVesalius, Rhinoceros, SolidWorks)...
July 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28708301/quantification-of-interfacial-motions-following-primary-and-revision-total-knee-arthroplasty-a-verification-study-versus-experimental-data
#7
Noel Conlisk, Colin R Howie, Pankaj Pankaj
Motion at the bone-implant interface, following primary or revision knee arthroplasty, can be detrimental to the long-term survival of the implant. This study employs experimentally verified computational models of the distal femur to characterize the relative motion at the bone-implant interface for three different implant types; a posterior stabilizing implant (PS), a total stabilizing implant (TS) with short stem (12 mm × 50 mm), and a total stabilizing implant (TS) with long offset stem (19 mm × 150 mm with a 4 mm lateral offset)...
July 14, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28707347/interspecific-variation-in-the-tetradactyl-manus-of-modern-tapirs-perissodactyla-tapirus-exposed-using-geometric-morphometrics
#8
Jamie A MacLaren, Sandra Nauwelaerts
The distal forelimb (autopodium) of quadrupedal mammals is a key morphological unit involved in locomotion, body support, and interaction with the substrate. The manus of the tapir (Perissodactyla: Tapirus) is unique within modern perissodactyls, as it retains the plesiomorphic tetradactyl (four-toed) condition also exhibited by basal equids and rhinoceroses. Tapirs are known to exhibit anatomical mesaxonic symmetry in the manus, although interspecific differences and biomechanical mesaxony have yet to be rigorously tested...
July 13, 2017: Journal of Morphology
https://www.readbyqxmd.com/read/28684196/force-transmission-through-the-wrist-during-performance-of-push-ups-on-a-hyperextended-and-a-neutral-wrist
#9
Olga Polovinets, Alon Wolf, Ronit Wollstein
STUDY DESIGN: Cross-sectional cohort. INTRODUCTION: Push-ups are used ubiquitously to evaluate and strengthen the upper body. They are usually performed in 1 of 2 main ways: with the wrist in hyperextension and with the wrist in a neutral position. PURPOSE OF THE STUDY: The purpose of our study was to compare the dynamic forces in the wrist during the 2 push-up styles. METHODS: Fourteen volunteers performed push-ups in 2 different patterns: on a hyperextended wrist and a neutral wrist (NW)...
July 3, 2017: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/28680554/characterization-and-antimicrobial-efficacy-of-portland-cement-impregnated-with-silver-nanoparticles
#10
Ki Young Nam
PURPOSE: This study investigated the effects of silver nanoparticle (SN) loading into hydraulic calcium silicate-based Portland cement on its mechanical, antibacterial behavior and biocompatibility as a novel dental bone substitute. MATERIALS AND METHODS: Chemically reduced colloidal SN were combined with Portland cement (PC) by the concentrations of 0 (control), 1.0, 3.0, and 5.0 wt%. The physico-mechanical properties of silver-Portland cement nanocomposites (SPNC) were investigated through X-ray diffraction (XRD), setting time, compressive strength, solubility, and silver ion elution...
June 2017: Journal of Advanced Prosthodontics
https://www.readbyqxmd.com/read/28656713/lateral-ridge-augmentation-with-two-different-ratios-of-deproteinized-bovine-bone-and-autogenous-bone-a-2-year-follow-up-of-a-randomized-and-controlled-trial
#11
Arne Mordenfeld, Hanna Aludden, Thomas Starch-Jensen
BACKGROUND: The optimal ratio of deproteinized bovine bone (DPBB) and autogenous bone (AB) for lateral augmentation is presently unknown. PURPOSE: To evaluate implant treatment outcome and radiological graft changes after lateral ridge augmentation with 2 different mixtures of DPBB and AB, 2 years after functional loading. MATERIALS AND METHODS: Thirteen patients were included in a split mouth, randomized, controlled trial. Four partially edentulous and 10 totally edentulous jaws with an alveolar ridge width of <4 mm were augmented with a graft mixture of 90:10 (DPBB:AB) on one side and 60:40 (DPBB:AB) on the contra lateral side...
June 28, 2017: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/28645665/experimental-evaluation-of-stress-distribution-with-narrow-diameter-implants-a-finite-element-analysis
#12
Sezgi Cinel, Ersan Celik, Elcin Sagirkaya, Onur Sahin
STATEMENT OF PROBLEM: Narrow diameter implants were developed to allow placement in narrow alveolar ridges. Clinicians may have concerns about the durability and function of such implants. PURPOSE: The purpose of this finite element study was to compare the stress values occurring on the implant and at the implant bone interface after the application of the static and dynamic forces on narrow diameter, titanium and titanium-zirconia implants in the maxillary and mandibular second premolar region...
June 20, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28641745/long-term-stability-of-an-injection-molded-zirconia-bone-level-implant-a-testing-protocol-considering-aging-kinetics-and-dynamic-fatigue
#13
Benedikt C Spies, Madeleine E Maass, Erik Adolfsson, Valter Sergo, Tobias Kiemle, Christoph Berthold, Elisa Gurian, Stefano Fornasaro, Kirstin Vach, Ralf-Joachim Kohal
OBJECTIVE: Separately addressing the fatigue resistance (ISO 14801, evaluation of final product) and aging behavior (ISO 13356, standardized sample) of oral implants made from yttria-stabilized zirconia proved to be insufficient in verifying their long-term stability, since (1) implant processing is known to significantly influence transformation kinetics and (2) aging, up from a certain level, is liable to decrease fatigue resistance. Therefore, the aim of this investigation was to apply a new testing protocol considering environmental conditions adequately inducing aging during dynamic fatigue...
June 20, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28640588/calcitonin-loaded-thermosensitive-hydrogel-for-long-term-antiosteopenia-therapy
#14
Yanpeng Liu, Xiaobin Chen, Sheyu Li, Qiang Guo, Jing Xie, Lin Yu, Xinyuan Xu, Chunmei Ding, Jianshu Li, Jiandong Ding
Effective antiosteopenia therapy can be achieved by designing long-term protein/peptide drug delivery systems for bone trabecula restoration. Here we show that a complex of salmon calcitonin and oxidized calcium alginate (sCT-OCA) was prepared and loaded into a thermosensitive copolymer hydrogel for long-term antiosteopenia treatment. The triblock copolymer, poly(d,l-lactic acid-co-glycolic acid)-b-poly(ethylene glycol)-b-poly(d,l-lactic acid-co-glycolic acid) (PLGA-PEG-PLGA) exhibited sol-gel transition at body temperature...
July 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28635249/perfluorocarbon-gold-loading-for-noninvasive-in-vivo-assessment-of-bone-fillers-using-19-f-magnetic-resonance-imaging-and-computed-tomography
#15
Simone Mastrogiacomo, Weiqiang Dou, Olga Koshkina, Otto C Boerman, John A Jansen, Arend Heerschap, Mangala Srinivas, X Frank Walboomers
Calcium phosphate cement (CPC) is used in bone repair because of its biocompatibility. However, high similarity between CPC and the natural osseous phase results in poor image contrast in most of the available in vivo imaging techniques such as computed tomography (CT) and magnetic resonance imaging (MRI). For accurate identification and localization during and after implantation in vivo, a composition with enhanced image contrast is needed. In this study, we labeled CPC with perfluoro-15-crown-5-ether-loaded (PFCE) poly(latic-co-glycolic acid) nanoparticles (hydrodynamic radius 100 nm) and gold nanoparticles (diameter 40 nm), as (19)F MRI and CT contrast agents, respectively...
July 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28633987/a-paradigm-shift-for-bone-quality-in-dentistry-a-literature-review
#16
REVIEW
Shinichiro Kuroshima, Masaru Kaku, Takuya Ishimoto, Muneteru Sasaki, Takayoshi Nakano, Takashi Sawase
PURPOSE: The aim of this study was to present the current concept of bone quality based on the proposal by the National Institutes of Health (NIH) and some of the cellular and molecular factors that affect bone quality. STUDY SELECTION: This is a literature review which focuses on collagen, biological apatite (BAp), and bone cells such as osteoblasts and osteocytes. RESULTS: In dentistry, the term "bone quality" has long been considered to be synonymous with bone mineral density (BMD) based on radiographic and sensible evaluations...
June 17, 2017: Journal of Prosthodontic Research
https://www.readbyqxmd.com/read/28627673/release-characteristics-of-bone%C3%A2-like-hydroxyapatite-poly-amino-acid-loaded-with-rifapentine-microspheres-in%C3%A2-vivo
#17
Yuwu Liu, Jiming Zhu, Dianming Jiang
Bone-like hydroxyapatite/poly amino acid (BHA/PAA) is a potential bone repair material. Rifapentine-loaded poly(lactic‑co‑glycolic acid) microspheres (RPMs) are bioactive and efficient controlled‑release delivery systems used in vitro. The aim of the present study was to investigate the in vivo drug release characteristics of RPM‑loaded BHA/PAA on a rabbit model of bone defect. RPM was combined with BHA/PAA to obtain the drug‑loaded, slow‑releasing bioactive material. Bone defects were generated in New Zealand white rabbits and the rabbits were then implanted with RPM‑loaded BHA/PAA...
August 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28601648/sequential-igf-1-and-bmp-6-releasing-chitosan-alginate-plga-hybrid-scaffolds-for-periodontal-regeneration
#18
Tuğba Duruel, Anıl Sera Çakmak, Abdullah Akman, Rahime M Nohutcu, Menemşe Gümüşderelioğlu
The goal of periodontal tissue engineering is to repair or regenerate the destructed or lost periodontium by improving functions of cells in the remaining tissue. For continuty of cell growth process, two group of growth factors, i.e. competence factors and progression factors, are needed to act together. However, the short biological half-life of these factors limits their effects on cells and their clinical efficacy. The purpose of this study is to develop different microparticles-loaded chitosan carriers/scaffolds for controlled and sequential delivery of a competence factor, insulin-like growth factor (IGF-1), and progression factor, bone morphogenetic factor-6 (BMP-6)...
June 7, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28584714/the-development-of-curvature-in-the-porcine-radioulna
#19
Jess Pantinople, Kyle McCabe, Keith Henderson, Hazel L Richards, Nick Milne
Long bone curvature in animal limbs has long been a subject of interest and much work has explored why long bones should be curved. However, the 'when' and 'how' of curvature development is poorly understood. It has been shown that the rat tibia fails to attain its normal curvature if the action of muscles is removed early in life, but it is not clear if this is because the curvature fails to develop or if the bone becomes straighter without the action of muscles. No studies have examined the development of bone curvature in a normally developing quadruped, so this study tracks the course of curvature formation in the radioulna in a series of growing pigs...
2017: PeerJ
https://www.readbyqxmd.com/read/28582642/movement-of-the-sacroiliac-joint-during-the-active-straight-leg-raise-test-in-patients-with-long-lasting-severe-sacroiliac-joint-pain
#20
Thomas J Kibsgård, Stephan M Röhrl, Olav Røise, Bengt Sturesson, Britt Stuge
BACKGROUND: The Active Straight Leg Raise is a functional test used in the assessment of pelvic girdle pain, and has shown to have good validity, reliability and responsiveness. The Active Straight Leg Raise is considered to examine the patients' ability to transfer load through the pelvis. It has been hypothesized that patients with pelvic girdle pain lack the ability to stabilize the pelvic girdle, probably due to instability or increased movement of the sacroiliac joint. This study examines the movement of the sacroiliac joints during the Active Straight Leg Raise in patients with pelvic girdle pain...
August 2017: Clinical Biomechanics
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