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https://www.readbyqxmd.com/read/28212706/sclerostin-antibody-inhibits-skeletal-deterioration-in-mice-exposed-to-partial-weight-bearing
#1
J M Spatz, R Ellman, A M Cloutier, L Louis, M van Vliet, D Dwyer, M Stolina, H Z Ke, M L Bouxsein
Whereas much is known regarding the musculoskeletal responses to full unloading, little is known about the physiological effects and response to pharmacological agents in partial unloading (e.g. Moon and Mars) environments. To address this, we used a previously developed ground-based model of partial weight-bearing (PWB) that allows chronic exposure to reduced weight-bearing in mice to determine the effects of murine sclerostin antibody (SclAbII) on bone microstructure and strength across different levels of mechanical unloading...
February 2017: Life Sciences in Space Research
https://www.readbyqxmd.com/read/28205407/collagen-fiber-orientation-in-primate-long-bones
#2
Johanna Warshaw, Timothy G Bromage, Carl J Terranova, Donald H Enlow
Studies of variation in orientation of collagen fibers within bone have lead to the proposition that these are preferentially aligned to accommodate different kinds of load, with tension best resisted by fibers aligned longitudinally relative to the load, and compression best resisted by transversely aligned fibers. However, previous studies have often neglected to consider the effect of developmental processes, including constraints on collagen fiber orientation (CFO), particularly in primary bone. Here we use circularly polarized light microscopy to examine patterns of CFO in cross-sections from the midshaft femur, humerus, tibia, radius and ulna in a range of living primate taxa with varied body sizes, phylogenetic relationships and positional behaviors...
February 16, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/28196619/development-and-verification-of-novel-porous-titanium-metaphyseal-cones-for-revision-total-knee-arthroplasty
#3
Ahmad Faizan, Manoshi Bhowmik-Stoker, Amanda E Kirk, Viktor E Krebs, Steven F Harwin, R Michael Meneghini
BACKGROUND: Porous metaphyseal cones are widely used in revision knee arthroplasty. A new system of porous titanium metaphyseal cones has been designed based on the femoral and tibial morphology derived from a computed tomography-based anatomical database. The purpose of this study is to evaluate the initial mechanical stability of the new porous titanium revision cone system by measuring the micromotion under physiologic loading compared with a widely-used existing porous tantalum metaphyseal cone system...
January 18, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28182119/biodegradable-mesoporous-delivery-system-for-biomineralization-precursors
#4
Hong-Ye Yang, Li-Na Niu, Jin-Long Sun, Xue-Qing Huang, Dan-Dan Pei, Cui Huang, Franklin R Tay
Scaffold supplements such as nanoparticles, components of the extracellular matrix, or growth factors have been incorporated in conventional scaffold materials to produce smart scaffolds for tissue engineering of damaged hard tissues. Due to increasing concerns on the clinical side effects of using large doses of recombinant bone-morphogenetic protein-2 in bone surgery, it is desirable to develop an alternative nanoscale scaffold supplement that is not only osteoinductive, but is also multifunctional in that it can perform other significant bone regenerative roles apart from stimulation of osteogenic differentiation...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28181688/dental-implants-and-bone-augmentation-in-hiv-infected-patients-under-haart-case-report-and-review-of-the-literature
#5
Fábio Vidal, Rafael Vidal, Jeter Bochnia, Rodrigo Carvalho de Souza, Lucio Souza Gonçalves
The present study reviewed the literature regarding dental implants in HIV-infected patients and reports the long-term follow-up of three clinical cases of patients under HAART that received bone augmentation and dental implants. The first case presents a young patient with a large defect in the mandible, as a consequence of a longitudinal fracture, that was treated with guided bone regeneration (GBR) previously to implant placement. The second case reported is middle-aged man with a fractured upper lateral incisor treated with immediate placement and simultaneous GBR to repair the dehiscence due to the buccal bone resorption...
February 9, 2017: Special Care in Dentistry
https://www.readbyqxmd.com/read/28154923/the-effect-of-impact-tool-geometry-and-soft-material-covering-on-long-bone-fracture-patterns-in-children
#6
Haim Cohen, Chen Kugel, Hila May, Bahaa Medlej, Dan Stein, Viviane Slon, Tamar Brosh, Israel Hershkovitz
INTRODUCTION: The effect of impact tool geometry and soft material covering on bone fracture patterns plays a major role in fracture patterns. However, the literature is nearly void of such studies and only general correlations between the fracture pattern and the mechanism underlying the insult were reported. PURPOSE: The aim of this study is to reveal the association between the geometry of the impact tool and the presence of soft material covering on bone fracture patterns...
February 2, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28144820/a-preclinical-numerical-assessment-of-a-polyetheretherketone-femoral-component-in-total-knee-arthroplasty-during-gait
#7
Lennert de Ruiter, Dennis Janssen, Adam Briscoe, Nico Verdonschot
BACKGROUND: Conventional total knee replacement designs show high success rates but in the long term, the stiff metal components may affect bone quality of the distal femur. In this study we introduce an all-polymer total knee replacement device containing a PEEK femoral component on an UHMWPE tibial implant and study its mechanical integrity, fixation, and stress shielding of the periprosthetic femur. METHODS: The implant was analysed in finite element simulations of level gait, adopted from the ISO 14243-1 standard...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28132525/influence-of-custom-made-implant-designs-on-the-biomechanical-performance-for-the-case-of-immediate-post-extraction-placement-in-the-maxillary-esthetic-zone-a-finite-element-analysis
#8
Jianyu Chen, Zhiguang Zhang, Xianshuai Chen, Xiao Zhang
Due to the increasing adoption of immediate implantation strategies and the rapid development of the computer aided design/computer aided manufacturing technology, a therapeutic concept based on patient-specific implant dentistry has recently been reintroduced by many researchers. However, little information is available on the designs of custom-made dental implant systems, especially their biomechanical behavior. The influence of the custom-made implant designs on the biomechanical performance for both an immediate and a delayed loading protocol in the maxillary esthetic zone was evaluated by means of the finite element (FE) method...
January 29, 2017: Computer Methods in Biomechanics and Biomedical Engineering
https://www.readbyqxmd.com/read/28128919/carbon-nanofiber-polycaprolactone-mineralized-hydroxyapatite-nanofibrous-scaffolds-for-potential-orthopedic-applications
#9
Shinyjoy Elangomannan, Kavitha Louis, Bhagya Mathi Dharmaraj, Venkata Saravanan Kandasamy, Kannan Soundarapandian, Dhanaraj Gopi
Hydroxyapatite (Ca10 (PO4)6(OH)2, HAP), a multimineral substituted calcium phosphate is one of the most substantial bone mineral component that has been widely used as bone replacement materials because of its bioactive and biocompatible properties. However, the use of HAP as bone implants is restricted due to its brittle nature and poor mechanical properties. To overcome this defect and to generate suitable bone implant material, HAP is combined with biodegradable polymer (polycaprolactone, PCL). To enhance the mechanical property of the composite, carbon nanofibers (CNF) is incorporated to the composite, which has long been considered for hard and soft tissue implant due to its exceptional mechanical and structural properties...
February 10, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28128420/grk2-desensitizes-flow-induced-responses-in-osteoblasts
#10
Y Xing, Y Gu, X Shan, L Wang, J You
Bone desensitization after mechanical loading is essential for bone to adapt to its mechanical environment. However, the desensitization mechanism is unknown. Previous studies suggest that G protein-coupled receptors (GPCRs), including P2Y and parathyroid hormone receptors, play important roles in osteoblast mechanobiology. Thus, for the present research, we examined the role of G protein-coupled receptor kinase 2 (GRK2) in osteoblast desensitization after exposure to mechanical stimulation. We first showed the existence of osteoblast desensitization after mechanical stimulation based on cytosol Ca(2+) and phosphorylated ERK1/2 activities, detected using a fluorescent Ca(2+)-sensitive dye and western blotting, respectively...
January 23, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28124077/long-term-treatment-effects-in-chronic-myeloid-leukemia
#11
Apollos Besse, Thomas Lepoutre, Samuel Bernard
We propose and analyze a simplified version of a partial differential equation (PDE) model for chronic myeloid leukemia (CML) derived from an agent-based model proposed by Roeder et al. This model describes the proliferation and differentiation of leukemic stem cells in the bone marrow and the effect of the drug Imatinib on these cells. We first simplify the PDE model by noting that most of the dynamics occurs in a subspace of the original 2D state space. Then we determine the dominant eigenvalue of the corresponding linearized system that controls the long-term behavior of solutions...
January 25, 2017: Journal of Mathematical Biology
https://www.readbyqxmd.com/read/28109795/bone-morphological-effects-on-post-implantation-remodeling-of-maxillary-anterior-buccal-bone-a-clinical-and-biomechanical-study
#12
Nobuhiro Yoda, Keke Zheng, Junning Chen, Wei Li, Michael Swain, Keiichi Sasaki, Qing Li
PURPOSE: This study combines clinical investigation with finite element (FE) analysis to explore the effects of buccal bone thickness (BBT) on the morphological changes of buccal bone induced by the loaded implant. METHODS: One specific patient who had undergone an implant treatment in the anterior maxilla and experienced the buccal bone resorption on the implant was studied. Morphological changes of the bone were measured through a series of cone-beam computed tomography (CT) scans...
January 18, 2017: Journal of Prosthodontic Research
https://www.readbyqxmd.com/read/28109138/adaptations-in-the-microarchitecture-and-load-distribution-of-maternal-cortical-and-trabecular-bone-in-response-to-multiple-reproductive-cycles-in-rats
#13
Chantal Mj de Bakker, Allison R Altman-Singles, Yihan Li, Wei-Ju Tseng, Connie Li, X Sherry Liu
Pregnancy, lactation, and weaning result in dramatic changes in maternal calcium metabolism. In particular, the increased calcium demand during lactation causes a substantial degree of maternal bone loss. This reproductive bone loss has been suggested to be largely reversible, as multiple clinical studies have found that parity and lactation history have no adverse effect on postmenopausal fracture risk. However, the precise effects of pregnancy, lactation, and post-weaning recovery on maternal bone structure are not well understood...
January 21, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28095521/evaluation-of-ultrashort-and-longer-implants-with-microrough-surfaces-results-of-a-24-to-36-month-prospective-study
#14
Luciano Malchiodi, Riccardo Caricasulo, Alessandro Cucchi, Raffaele Vinci, Enrico Agliardi, Enrico Gherlone
PURPOSE: The aim of this prospective study was to establish if ultrashort implants are a reliable therapeutic solution by evaluating their effect on mean crestal bone loss and assessing their survival and success rates. MATERIALS AND METHODS: Patients were treated using 6-, 9-, and 11-mm-long implants with sandblasted and acid-etched surfaces and fitted with fixed partial prostheses. Clinical and radiographic examinations were scheduled yearly. Data collected included the implant positioning site, implant length and diameter, peri-implant bone loss (PBL), and clinical and anatomical C/I ratios...
January 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28095517/radiographic-evaluation-of-crestal-bone-level-in-split-crest-and-immediate-implant-placement-minimum-5-year-follow-up
#15
Giovanni B Bruschi, Paolo Capparé, Fabrizio Bravi, Nicola Grande, Enrico Gherlone, Giorgio Gastaldi, Roberto Crespi
PURPOSE: This study aimed to evaluate the radiographic bone level changes of implants positioned via the split-crest procedure both in the maxilla and mandible at a long-term follow-up. MATERIALS AND METHODS: Seventy-one patients were retrospectively enrolled in the study. The placement of 137 dental implants was performed in the edentulous premolar or molar region after a split-crest ridge expansion procedure. Implants followed a delayed loading protocol. Intraoral digital radiographs were performed at baseline, upon implant placement, at 70 days (following placement of the provisional prosthesis), and on a yearly basis during followup...
January 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28081288/short-dental-implants-6-mm-versus-long-dental-implants-11-15-mm-in-combination-with-sinus-floor-elevation-procedures-3-year-results-from-a-multi-center-randomized-controlled-clinical-trial
#16
Veronika Pohl, Daniel S Thoma, Katarzyna Sporniak-Tutak, Abel Garcia-Garcia, Thomas D Taylor, Robert Haas, Christoph H F Hämmerle
AIM: To test whether or not the use of short dental implants (6 mm) results in an implant survival rate similar to that with longer implants (11-15 mm) in combination with sinus grafting. METHODS: This multi-center study enrolled 101 patients with partial edentulism in the posterior maxilla and a remaining bone height of 5-7 mm. Included patients were randomly assigned to receive short implants (6 mm; GS / group short) or long implants (11-15 mm) simultaneously with sinus grafting (GG / group graft)...
January 12, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28073075/freeform-extrusion-fabrication-of-titanium-fiber-reinforced-13-93-bioactive-glass-scaffolds
#17
Albin Thomas, Krishna C R Kolan, Ming C Leu, Gregory E Hilmas
Although implants made with bioactive glass have shown promising results for bone repair, their application in repairing load-bearing long bone is limited due to their poor mechanical properties in comparison to human bone. This work investigates the freeform extrusion fabrication of bioactive silicate 13-93 glass scaffolds reinforced with titanium (Ti) fibers. A composite paste prepared with 13-93 glass and Ti fibers (~16µm in diameter and lengths varying from ~200µm to ~2 mm) was extruded through a nozzle to fabricate scaffolds (0-90° filament orientation pattern) on a heated plate...
December 31, 2016: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28071641/epidemiological-data-and-case-load-spectrum-of-patients-presenting-to-bone-and-soft-tissue-disease-management-group-at-a-tertiary-cancer-center
#18
A Gulia, A Puri, S Chorge, P K Panda
INTRODUCTION AND BACKGROUND: This study was conducted to know the spectrum and number of bone and soft tissue (BST) tumors presenting to our institute. We needed to assess the gap between the number of patients seen and infrastructure available, and based on this information, help formulate guidelines for optimum utilization of resources and to provide best possible evidence-based cancer care. SETTINGS AND DESIGNS: This is a prospective observational study (epidemiological)...
April 2016: Indian Journal of Cancer
https://www.readbyqxmd.com/read/28057631/ultimate-fracture-load-of-cadaver-proximal-humeri-correlates-more-strongly-with-mean-combined-cortical-thickness-than-with-areal-cortical-index-dexa-density-or-canal-to-calcar-ratio
#19
J G Skedros, C S Mears, W Z Burkhead
OBJECTIVES: This investigation sought to advance the work published in our prior biomechanical study (Journal of Orthopaedic Research, 2016). We specifically sought to determine whether there are additional easy-to-measure parameters on plain radiographs of the proximal humerus that correlate more strongly with ultimate fracture load, and whether a parameter resembling the Dorr strength/quality characterisation of proximal femurs can be applied to humeri. MATERIALS AND METHODS: A total of 33 adult humeri were used from a previous study where we quantified bone mineral density of the proximal humerus using radiographs and dual-energy x-ray absorptiometry (DEXA), and regional mean cortical thickness and cortical index using radiographs...
January 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28054122/-steel-or-titanium-for-osteosynthesis-a%C3%A2-mechanobiological-perspective
#20
M Heyland, G N Duda, S Märdian, M Schütz, M Windolf
BACKGROUND: An implant used for stabilizing a fracture creates a mechanical construct, which directly determines the biology of bone healing. The stabilization of fractures places high mechanical demands on implants and therefore steel and titanium are currently almost exclusively used as the materials of choice. OBJECTIVES: The possible range of attainable mechanobiological stimulation for mechanotherapy as a function of plate stiffness depending on the selection of the plate material and the physical and mechanical properties of the material options are discussed...
January 4, 2017: Der Unfallchirurg
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