Read by QxMD icon Read

Pathogenesis epidemiology central venous catheters

Massimo Franchini
There are a growing number of studies documenting that, similarly to patients with solid cancers, also patients with hematological malignancies (i.e., acute leukemia, lymphoproliferative and myeloproliferative neoplasms and plasma cell disorders) are at increased risk of thrombosis. The pathogenesis of the hypercoagulable state associated with hematological cancers is often multifactorial. Contributor factors include tumor cell-derived procoagulants, antineoplastic therapies, central venous catheters, concomitant infections and advanced age...
July 2015: Clinical Chemistry and Laboratory Medicine: CCLM
Cristiane Silveira Brito, Rosineide Marques Ribas, Daiane Silva Resende, Denise Von Dolinger de Brito, Vânia Olivetti Steffen Abdallah, Kátia Regina Netto dos Santos, Fernanda Sampaio Cavalcante, Pricilla Dias Moura de Matos, Paulo P Gontijo Filho
OBJECTIVE: To investigate the pathogenesis of bloodstream infection by Staphylococcus epidermidis, using the molecular epidemiology, in high-risk neonates. METHODS: We conducted a prospective study of a cohort of neonates with bloodstream infection using central venous catheters for more than 24h. "National Healthcare Safety Network" surveillance was conducted. Genotyping was performed by DNA fingerprinting and mecA genes and icaAD were detected by multiplex-PCR...
July 2014: Brazilian Journal of Infectious Diseases
Vineet Gupta, Mohamed H Yassin
The incidence of end-stage renal disease (ESRD) has almost doubled over past 2 decades. Despite decreasing overall hospital admission rates for ESRD population, the rate of infection-related hospitalizations has steadily increased. Infection remains the second most common cause of mortality in this patient population. Specifically, in the hemodialysis (HD) patients, the vascular access related infections are the most common identifiable source of infection. This concise review provides an update on the bacteremia related to vascular access primarily the catheters (Catheter Related Blood Stream Infection- CRBSI) in HD patients emphasizing on the determinants ranging from the epidemiology to pathogenesis, risk factors, cost implications and prevention...
June 2013: Infectious Disorders Drug Targets
T Peel, A C Cheng, T Spelman, M Huysmans, D Spelman
Enterococcus is an important cause of bacteraemia. Previous epidemiological studies examining risk factors for enterococcal bacteraemia have used traditional case-control study designs, which can be potentially biased. This case-case-control study examining risk factors for enterococcal bacteraemia was conducted over 10 years (January 2000 to December 2009) in a tertiary, university-affiliated hospital. There were 440 episodes of enterococcal bacteraemia, 80 of which were caused by vancomycin-resistant Enterococcus (VRE)...
April 2012: Clinical Microbiology and Infection
Markus Ruhnke, Volker Rickerts, Oliver A Cornely, Dieter Buchheidt, Andreas Glöckner, Werner Heinz, Rainer Höhl, Regine Horré, Meinolf Karthaus, Peter Kujath, Birgit Willinger, Elisabeth Presterl, Peter Rath, Jörg Ritter, Axel Glasmacher, Cornelia Lass-Flörl, Andreas H Groll, German Speaking Mycological Society, Paul-Ehrlich-Society for Chemotherapy
Invasive Candida infections are important causes of morbidity and mortality in immunocompromised and hospitalised patients. This article provides the joint recommendations of the German-speaking Mycological Society (Deutschsprachige Mykologische Gesellschaft, DMyKG) and the Paul-Ehrlich-Society for Chemotherapy (PEG) for diagnosis and treatment of invasive and superficial Candida infections. The recommendations are based on published results of clinical trials, case-series and expert opinion using the evidence criteria set forth by the Infectious Diseases Society of America (IDSA)...
July 2011: Mycoses
Charmaine E Lok, Michele H Mokrzycki
Central venous catheter-related infections have been associated with high morbidity, mortality, and costs. Catheter use in chronic hemodialysis patients has been recognized as distinct from other patient populations who require central venous access, leading to recent adaptations in guidelines-recommended diagnosis for catheter-related bacteremia (CRB). This review will discuss the epidemiology and pathogenesis of hemodialysis CRB, in addition to a focus on interventions that have favorably affected CRB outcomes...
March 2011: Kidney International
Leonidia Leonidou, Charalambos A Gogos
Central-line access is an essential part of modern healthcare practice; however, catheter-related bloodstream infection is a major problem that causes substantial morbidity and mortality, and excess length of stay and cost. The risk of infection depends on the type of device, the site of insertion, the underlying conditions and the appropriate prevention measures taken during catheter insertion. Management of catheter-related bloodstream infection involves deciding on catheter removal, antimicrobial catheter lock solution and the type and duration of systemic antimicrobial therapy...
December 2010: International Journal of Antimicrobial Agents
Monika Joks, Renata Kroll, Mieczysław Komarnicki
Central venous catheters (CVC) are frequently used in patients with a hematological disorders in order to administer drugs, stem cell infusions, blood products, parenteral alimentation as well as for blood sampling. There are known mechanical, infectious and thrombotic complications of central venous catheters in hematological patients. Infectious and thrombotic complications have been considered as separate entities so far, but there are theory and accumulating evidence that they are interrelated. Since data on central venous catheters-related thrombosis in hematological patients have been obtained mainly from retrospective studies of small size, prospective randomized studies are warranted...
2010: Przegla̧d Lekarski
Jeffery S Garland, Colleen P Alex, Jackie M Sevallius, Dawn M Murphy, Mary J Good, Annette M Volberding, Leslie L Hofer, Barbara J Gordon, Dennis G Maki
OBJECTIVE: To better define the pathogenesis of catheter-related bloodstream infection (BSI) in neonates with peripherally inserted central venous catheters (PICCs) to guide the development of more effective strategies for prevention. DESIGN: Prospective nested cohort study. SETTING: Level III neonatal intensive care unit in a community hospital. METHODS: During a randomized trial to assess the safety and efficacy of a prophylactic vancomycin-heparin catheter-lock solution for the prevention of catheter-related BSI in neonates with PICCs, we performed cultures of peripheral and catheter-drawn blood samples, and quantitative cultures of catheter hub samples if BSI was suspected clinically...
March 2008: Infection Control and Hospital Epidemiology
Melina Verso, Giancarlo Agnelli
Long-term central venous catheters (CVCs) have considerably improved the management of cancer patients because they facilitate chemotherapy, transfusions, parenteral nutrition, and blood sampling. However, the use of long-term CVCs, especially for chemotherapy, has been associated with the occurrence of upper-limb deep venous thrombosis (UL-DVT). The incidence of clinically overt UL-DVT related to CVCs has been reported to vary between 0.3% and 28.3%. The incidence of CVC-related UL-DVT screened by venography reportedly varies between 27% and 66%...
October 1, 2003: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Joan N Hebden
Although intravascular catheters are indispensable for managing the care of critically ill patients, they can be associated with serious infection. Catheter-related bloodstream infections (CR-BSI) are a major cause of morbidity and mortality in the critical care setting. These infections are largely preventable. This article reviews the epidemiology and pathogenesis of these infections, the role of the critical care nurse in the diagnostic evaluation of CR-BSI, and strategies for their prevention.
August 2002: AACN Clinical Issues
L A Mermel, B M Farr, R J Sherertz, I I Raad, N O'Grady, J S Harris, D E Craven
These guidelines from the Infectious Diseases Society of America (IDSA), the American College of Critical Care Medicine (for the Society of Critical Care Medicine), and the Society for Healthcare Epidemiology of America contain recommendations for the management of adults and children with, and diagnosis of infections related to, peripheral and nontunneled central venous catheters (CVCs), pulmonary artery catheters, tunneled central catheters, and implantable devices. The guidelines, written for clinicians, contain IDSA evidence-based recommendations for assessment of the quality and strength of the data...
May 2001: Journal of Intravenous Nursing: the Official Publication of the Intravenous Nurses Society
J Nielsen, S D Ladefoged, H J Kolmos
BACKGROUND: Dialysis catheters are a common cause of nosocomial septicaemia in haemodialysis units usually due to staphylococci, of which Staphylococcus aureus is the most pathogenic. In this study, the epidemiology and pathogenesis of dialysis catheter-related infections were studied, and methods to identify patients with these infections were evaluated. METHODS: A one-year prospective study of 67 catheters in 43 haemodialysis patients was performed. Details about patients and catheters were obtained successively during the catheter period, and biochemical parameters expected to be related to infection were measured...
November 1998: Nephrology, Dialysis, Transplantation
J M Llop Talaverón, M Rey Salido, M Tubau Molas, R Verdaguer Riu, J M Ramón Torrell, L Pastó Cardona, I Manges Bafalluy
The objective of the study is, on one hand, to determine the etiology and the clinical implications as a function of the isolated germ, of central venous catheterization in patients with parenteral nutrition in our hospital, and on the other hand, to determine which factors are associated with the selection of germs of central venous catheterization in parenteral nutrition. For this we included venous catheters, colonized for 5 years, and with a study of the different segments (connection, insertion point, and tip)...
March 1996: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"