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https://www.readbyqxmd.com/read/29245070/blood-brain-barrier-permeability-and-neuroprotective-effects-of-three-main-alkaloids-from-the-fruits-of-euodia-rutaecarpa-with-mdck-phamdr-cell-monolayer-and-pc12-cell-line
#1
Yi-Nan Zhang, Yan-Fang Yang, Xiu-Wei Yang
The fruits of Euodia rutaecarpa (Euodiae Fructus, EF), the widely used traditional Chinese medicine, have various central nervous system effects. Alkaloids following as evodiamine (EDM), rutaecarpine (RCP) and dehydroevodiamine (DEDM) are the major substances in EF. The MDCK-pHaMDR cell monolayer model was utilized as a blood-brain barrier (BBB) surrogate model to study their BBB permeability. The transport samples were analyzed by high performance liquid chromatography and the apparent permeability coefficients (Papp) were calculated...
December 12, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29244264/personality-traits-and-anxiety-and-depressive-disorders-in-patients-with-medication-overuse-headache-versus-episodic-migraine
#2
Nima Mohseni, Mansooreh Togha, Seyed Masoud Arzaghi, Sepideh Nekooie, Mehrnaz Fallah Tafti, Farzad Fatehi
Objective: An episodic migraine (EM) may lead to medication-overuse headache (MOH), an abnormal behavioral pattern of noncompliance. Anxiety disorders, mood disorders, and disorders caused by psychoactive substances other than analgesics all have been reported with MOH at higher rates than with EM. The objective of this study was to evaluate the relationships between personality traits and anxiety and depressive disorders and headache type. Methods: In this cross-sectional study, 55 patients with EM and 50 patients with MOH were recruited from were recruited from 2 university hospital clinics in Tehran, Iran, from January 2013 to November 2015...
December 14, 2017: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/29243564/deportation-of-non-citizen-military-veterans-a-critical-analysis-of-implications-for-the-right-to-health
#3
Danielle Horyniak, Ietza Bojorquez, Richard F Armenta, Peter J Davidson
Military personnel are commonly exposed to health-harming conditions during their service, resulting in higher rates of physical and mental health conditions compared with the general population. In an era of mass deportations, it is notable that non-citizen military veterans are not exempt from deportation. We utilised a human rights framework to conduct a critical analysis of potential health consequences of deportation for U.S. military veterans, identifying three ways in which veterans' rights to health may be constrained through deportation...
December 15, 2017: Global Public Health
https://www.readbyqxmd.com/read/29242964/-bone-substitute-materials-as-local-drug-carriers-current-status-of-substitutes-of-various-origins
#4
REVIEW
K-D Kühn, C Berberich, H Bösebeck
BACKGROUND: Autologous bone grafts (autografts) are used in surgery for defect filling and impaction grafting during hip socket and femur reconstruction. Because of their superior osteoinductive capacity, autografts are considered the "gold standard" for these treatments. However, because of a better cost-benefit ratio, allografts are also often used. In the case of limited donor availability for autologous or allogenic bone grafts, bone substitute materials (BSMs) are a reasonable alternative or supplement...
December 14, 2017: Der Orthopäde
https://www.readbyqxmd.com/read/29241648/different-effects-of-caffeine-on-behavioral-neurophenotypes-of-two-zebrafish-populations
#5
Luiz Vinícius Rosa, Ana Paula Ardais, Fabiano Vargas Costa, Barbara Dotto Fontana, Vanessa Andreatta Quadros, Lisiane Oliveira Porciúncula, Denis Broock Rosemberg
Caffeine is a substance present in several foods and drinks of common western diet. Although high caffeine concentrations induce anxiogenic properties in various species, the influence of the different baselines of anxiety levels on caffeine-mediated responses is poorly understood. The short-fin wild-type (WT) and leopard (leo) zebrafish populations present significant behavioral differences, in which leo shows exacerbated anxiety-like responses. Since behavioral neurophenotyping may be easily assessed in adult zebrafish by associating temporal and spatial three-dimensional reconstructions of locomotion, we investigated the effects of caffeine on exploration and anxiety-like behavior of WT and leo zebrafish...
December 11, 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/29241319/effects-of-six-substances-on-the-growth-and-freeze-drying-of-lactobacillus-delbrueckii-subsp-bulgaricus
#6
He Chen, Jie Huang, Xiaoyu Shi, Yichao Li, Yu Liu
BACKGROUND: The efficacy of Lactobacillus delbrueckii subsp. bulgaricus as starter cultures for the dairy industry depends largely on the number of viable and active cells. Freeze-drying is the most convenient and successful method to preserve the bacterial cells. However, not all strains survived during freeze-drying. METHODS: The effects of six substances including NaCl, sorbitol, mannitol, mannose, sodium glutamate, betaine added to the MRS medium on the growth and freeze-drying survival rate and viable counts of Lb...
October 2017: Acta Scientiarum Polonorum. Technologia Alimentaria
https://www.readbyqxmd.com/read/29236389/fecal-short-chain-fatty-acids-at-different-time-points-after-ceftriaxone-administration-in-rats
#7
Yu V Holota, O O Holubenko, A M Ostapchuk, T M Serhiychuk, L V Zakordonets, G M Tolstanova
Short-chain fatty acids (SCFAs) are major products of the microbial fermentation of dietary fiber in the colon. Recent studies suggest that these products of microbial metabolism in the gut act as signaling molecules, influence host energy homeostasis and play major immunological roles. In the present study, defined the long-term effects of ceftriaxone administration on the fecal SCFAs concentration in Wistar rats. Ceftriaxone (300 mg/kg, i.m.) was administered daily for 14 days. Rats were euthanized in 1, 15 and 56 days after ceftriaxone withdrawal...
January 2017: Ukrainian Biochemical Journal
https://www.readbyqxmd.com/read/29236090/novel-hydrogel-advanced-modified-clay-nanocomposites-as-possible-vehicles-for-drug-delivery-and-controlled-release
#8
Raluca Ianchis, Claudia M Ninciuleanu, Ioana C Gifu, Elvira Alexandrescu, Raluca Somoghi, Augusta R Gabor, Silviu Preda, Cristina L Nistor, Sabina Nitu, Cristian Petcu, Madalina Icriverzi, Paula E Florian, Anca M Roseanu
Present study refers to the synthesis of new advanced materials based on poly(methacrylic acid) (PMAA) with previously reported own advanced modified clays by edge covalent bonding. This will create the premises to obtain nanocomposite hydrogels with combined hydrophilic-hydrophobic behavior absolutely necessary for co-delivery of polar/nonpolar substances. For the synthesis, N,N'-methylenebisacrylamide was used as cross-linker and ammonium persulphate as initiator. As a consequence of the inclusion of clay into the polymer matrix and the intercalation of PMAA between the layers as well as the presence of hydrophobic interactions occurred between partners, the final hydrogel nanocomposites possessed greater swelling degrees, slower de-swelling process and enhanced mechanical properties depending on the clay type in comparison with pure hydrogel...
December 13, 2017: Nanomaterials
https://www.readbyqxmd.com/read/29234376/roles-of-nitric-oxide-and-prostaglandins-in-the-sustained-antihypertensive-effects-of-acanthospermum-hispidum-dc-on-ovariectomized-rats-with-renovascular-hypertension
#9
Rhanany Alan Calloi Palozi, Maysa Isernhagen Schaedler, Cleide Adriane Signor Tirloni, Aniely Oliveira Silva, Francislaine Aparecida Dos Reis Lívero, Roosevelt Isaias Carvalho Souza, Ariany Carvalho Dos Santos, Thiago Bruno Lima Prando, Lauro Mera de Souza, Arquimedes Gasparotto Junior
Although Acanthospermum hispidum is used in Brazilian folk medicine as an antihypertensive, no study evaluated its effects on a renovascular hypertension and ovariectomy model. So, this study investigated the mechanisms involved in the antihypertensive effects of an ethanol-soluble fraction obtained from A. hispidum (ESAH) using two-kidney-one-clip hypertension in ovariectomized rats (2K1C plus OVT). ESAH was orally administered at doses of 30, 100, and 300 mg/kg, daily, for 28 days, after 5 weeks of surgery...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29230921/global-grass-poaceae-success-underpinned-by-traits-facilitating-colonization-persistence-and-habitat-transformation
#10
H P Linder, Caroline E R Lehmann, Sally Archibald, Colin P Osborne, David M Richardson
Poaceae (the grasses) is arguably the most successful plant family, in terms of its global occurrence in (almost) all ecosystems with angiosperms, its ecological dominance in many ecosystems, and high species richness. We suggest that the success of grasses is best understood in context of their capacity to colonize, persist, and transform environments (the "Viking syndrome"). This results from combining effective long-distance dispersal, efficacious establishment biology, ecological flexibility, resilience to disturbance and the capacity to modify environments by changing the nature of fire and mammalian herbivory...
December 12, 2017: Biological Reviews of the Cambridge Philosophical Society
https://www.readbyqxmd.com/read/29230816/how-grinding-levels-and-brewing-methods-espresso-american-turkish-could-affect-the-antioxidant-activity-and-bioactive-compounds-in-a-coffee-cup
#11
Antonio Derossi, Ilde Ricci, Rossella Caporizzi, Anna Fiore, Carla Severini
BACKGROUND: Depending on geographical origins and cultural traditions, different brewing procedures are used all over the world to prepare a coffee cup. In this work, we explored as three grinding levels of coffee powder and three coffee preparation methods such as by filtration (American), by boiling (Turkish) and by extraction under pressure (Espresso) affect healthy compounds and physicochemical attributes in coffee cup served to consumers. RESULTS: the grinding level slightly affects the quality of coffees, while the preparation methods significantly influenced all in-cup attributes...
December 11, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29230810/trauma-exposure-interacts-with-the-genetic-risk-of-bipolar-disorder-in-alcohol-misuse-of-us-soldiers
#12
R Polimanti, J Kaufman, H Zhao, H R Kranzler, R J Ursano, R C Kessler, M B Stein, J Gelernter
OBJECTIVE: To investigate whether trauma exposure moderates the genetic correlation between substance use disorders and psychiatric disorders, we tested whether trauma exposure modifies the association of genetic risks for mental disorders with alcohol misuse and nicotine dependence (ND) symptoms. METHODS: High-resolution polygenic risk scores (PRSs) were calculated for 10 732 US Army soldiers (8346 trauma-exposed and 2386 trauma-unexposed) based on genome-wide association studies of bipolar disorder (BD), major depressive disorder, and schizophrenia...
December 11, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/29227894/substance-induced-psychotic-symptoms-in-borderline-personality-disorder-among-substance-use-disorder-samples-in-spain
#13
Carmen Barral, Laia Rodríguez-Cintas, Lara Grau-López, Constanza Daigre, Elena Ros-Cucurull, Natalia Calvo, Marc Ferrer, Carlos Roncero
Substance-induced psychosis (SIP) is frequent in substance use disorder patients. However, little is known about the presence of SIP in Borderline Personality Disorder (BPD) and what the risk factors for the development of SIP in this population would be. A sample of 91 BPD drug-dependent patients attending an outpatient substance use disorder unit was evaluated. Comorbidity with Axis I and II was assessed using SCID-I and SCID-II. Psychoactive drug related variables were registered as well as the presence of the ninth criterion of DSM-IV-TR as a code of psychotic symptoms...
December 6, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29225887/a-prospective-longitudinal-study-of-men-with-borderline-personality-disorder-with-and-without-comorbid-antisocial-personality-disorder
#14
Marie-Pier Robitaille, Dave Checknita, Frank Vitaro, Richard E Tremblay, Joel Paris, Sheilagh Hodgins
Background: Some evidence suggests that the prevalence of Borderline Personality Disorder (BPD) is elevated among male criminal offenders. It is not presently known whether offending, and violent offending, are limited to those presenting comorbid Antisocial Personality Disorder (ASPD) who have a childhood history of conduct problems and whether offending is linked to psychopathic traits. Methods: A community sample of 311 males followed from age 6 to 33 years, one third of whom had a criminal charge between ages 18 and 24, completed diagnostic interviews and the Psychopathy Checklist-Revised interview...
2017: Borderline Personality Disorder and Emotion Dysregulation
https://www.readbyqxmd.com/read/29225409/school-context-and-american-indian-substance-use
#15
David Eitle, Maggie Thorsen, Tamela McNulty Eitle
The present study extends prior research exploring the role of school contextual factors in predicting individual adolescent substance use by examining how a school's racial composition is associated with American Indian adolescent tobacco and marijuana use. Using a subsample of 523 American Indian students from the restricted use Add Health data, we consider both individual and school contextual factors across 99 schools. Our results suggest that a school's racial composition is associated with individual tobacco and marijuana use among American Indian youth, but in different ways depending upon the substance...
December 2017: Social Science Journal
https://www.readbyqxmd.com/read/29225041/syringaresinol-suppresses-excitatory-synaptic-transmission-and-picrotoxin-induced-epileptic-activity-in-the-hippocampus-through-presynaptic-mechanisms
#16
Young Seon Cho, Woo Seok Song, Sang Ho Yoon, Kyeong-Yeol Park, Myoung-Hwan Kim
Many neuromodulating drugs acting on the nervous system originate from botanical sources. These plant-derived substances modulate the activity of receptors, ion channels, or transporters in neurons. Their properties make the substances useful for medicine and research. Here, we show that the plant lignan (+)-syringaresinol (SYR) suppresses excitatory synaptic transmission via presynaptic modulation. Bath application of SYR rapidly reduced the slopes of the field excitatory postsynaptic potentials (fEPSPs) at the hippocampal Schaffer collateral (SC)-CA1 synapse in a dose-dependent manner...
December 7, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29224920/-cognitive-doping-in-students-a-chim-er-ical-way-to-get-full-head
#17
Louise Carton, Nicolas Cabé, Olivier Ménard, Sylvie Deheul, Anne-Sylvie Caous, David Devos, Olivier Cottencin, Régis Bordet
For students, the requirements for memorization, increased performance and peer competition may encourage cognitive doping behaviors. We aimed to describe recent practices and the benefit/risk ratio of such behavior to discuss the different issues. The prevalence of cognitive doping among students was 1.3% to 33% according to the studies, depending on the country concerned and the definition of cognitive doping used. The therapeutic classes most frequently cited as being diverted were psychostimulants and nootropics (methylphenidate, modafinil, piracetam), corticosteroids, sedative drugs and beta-blockers...
November 22, 2017: Thérapie
https://www.readbyqxmd.com/read/29224508/linear-and-cyclic-oligomers-in-polybutylene-terephthalate-for-food-contact-materials
#18
Fabrian Brenz, Susanne Linke, Thomas Simat
Polybutylene terephthalate (PBT) is a polyester (PES) gaining more importance on the food contact material (FCM) market. However, little is known about the potential migration of PBT oligomers which are formed during the polymer production. In this work, PBT pellets and a slotted spoon manufactured from this material by injection moulding were analysed on extractable oligomers and their migration potential into hydrophilic foods. Overall 27 oligomers (cycles and linears) could be identified in different extracts by HPLC-DAD/ESI-MS data, but without confirmation by reference substances...
December 11, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/29224181/social-cognition-and-aggression-in-methamphetamine-dependence-with-and-without-a-history-of-psychosis
#19
Anne Uhlmann, Jonathan C Ipser, Don Wilson, Dan J Stein
In substance use and psychotic disorders, socially problematic behaviours, such as high aggression may, in part, be explained by deficits in social cognition skills, like the detection of emotions or intentions in others. The aim of this study was to assess the magnitude of social cognition impairment and its association with aggression in individuals with methamphetamine (MA) dependence, methamphetamine-associated psychosis (MAP), and healthy controls (CTRL). A total of 20 MAP participants, 21 MA-dependent participants without psychosis, and 21 CTRL participants performed a facial morphing emotion recognition task (ERT) across four basic emotions (anger, fear, happiness and sadness) and the reading the mind in the eyes task (RMET), and completed the aggression questionnaire...
December 9, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29224006/epigenetic-regulation-of-the-promotor-region-of-vascular-endothelial-growth-factor-a-and-nerve-growth-factor-in-opioid-maintained-patients
#20
Adrian Groh, Kirsten Jahn, Alexandra Burkert, Alexandra Neyazi, Laura Schares, Eva Janke, Marie Rehme, Rilana Schuster, Thomas Hillemacher, Stefan Bleich, Helge Frieling, Annemarie Heberlein
AIMS: The nerve growth factor (NGF) and the vascular endothelial growth factor-A (VEGF-A) may be of importance for psychiatric diseases including substance use disorders. The aim of the study was to identify differences in the regulation of both neuropeptides via the DNA-methylation status of the promotor regions of NGF and VEGF-A in different forms of maintenance therapy for opioid dependence and the related stress regulation via the hypothalamic-pituitary-adrenal axis. METHODS: We compared methylation levels of opioid-dependent patients receiving treatment with diamorphine (n = 28) or levomethadone (n = 54) and similar levels in a healthy control group (n = 72)...
December 8, 2017: European Addiction Research
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