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https://www.readbyqxmd.com/read/28110046/response-of-spirodela-polyrhiza-to-cerium-subcellular-distribution-growth-and-biochemical-changes
#1
Qinsong Xu, Yuji Jiang, Weiyue Chu, Chunlei Su, Dan Hu, Qianqian Lu, Tingting Zhang
Rare earth elements are new and emerging contaminants in freshwater systems. Greater duckweed (Spirodela polyrhiza L.) is a common aquatic plant widely used in phytotoxicity tests for xenobiotic substances. In this study, the cerium (Ce) accumulation potential, the distribution of Ce in bio-molecules, and ensuing biochemical responses were investigated in greater duckweed fronds when they were exposed to Ce (0, 10, 20, 40, and 60μM). There was a concentration dependent increase in Ce accumulation, which reached a maximum of 67mgg(-1) of dry weight (DW) at 60μM Ce after 14 d...
January 19, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28109891/redox-regulation-of-electrophilic-signaling-by-reactive-persulfides-in-cardiac-cells
#2
REVIEW
Motohiro Nishida, Akiyuki Nishimura, Tetsuro Matsunaga, Hozumi Motohashi, Shingo Kasamatsu, Takaaki Akaike
Maintaining a redox balance by means of precisely controlled systems that regulate production, and elimination, and metabolism of electrophilic substances (electrophiles) is essential for normal cardiovascular function. Electrophilic signaling is mainly regulated by endogenous electrophiles that are generated from reactive oxygen species, nitric oxide, and the derivative reactive species of nitric oxide during stress responses, as well as by exogenous electrophiles including compounds in foods and environmental pollutants...
January 18, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28107829/high-throughput-online-solid-phase-extraction-ultra-high-performance-liquid-chromatography-tandem-mass-spectrometry-method-for-polyfluoroalkyl-phosphate-esters-perfluoroalkyl-phosphonates-and-other-perfluoroalkyl-substances-in-human-serum-plasma-and-whole-blood
#3
Somrutai Poothong, Elsa Lundanes, Cathrine Thomsen, Line Småstuen Haug
A rapid, sensitive and reliable method was developed for the determination of a broad range of poly- and perfluoroalkyl substances (PFASs) in various blood matrices (serum, plasma, and whole blood), and uses only 50 μL of sample material. The method consists of a rapid protein precipitation by methanol followed by high throughput online solid phase extraction (SPE), ultra-high performance liquid chromatography coupled with tandem mass spectrometry (UHPLC-MS/MS), and negative electrospray ionization detection...
March 8, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28106934/neuroimaging-the-neural-correlates-of-increased-risk-for-substance-use-disorders-in-attention-deficit-hyperactivity-disorder-a-systematic-review
#4
Vitria Adisetiyo, Kevin M Gray
BACKGROUND/OBJECTIVES: Children with attention-deficit/hyperactivity disorder (ADHD) are nearly three times more likely to develop substance use disorders (SUD) than their typically developing peers. Our objective was to review the existing neuroimaging research on high-risk ADHD (ie, ADHD with disruptive behavior disorders, familial SUD and/or early substance use), focusing on impulsivity as one possible mechanism underlying SUD risk. METHODS: A PubMed literature search was conducted using combinations of the keywords "ADHD," "substance use," "substance use disorder," "SUD," "addiction," "dependence," "abuse," "risk," "brain" "MRI," "imaging" and "neuroimaging...
January 20, 2017: American Journal on Addictions
https://www.readbyqxmd.com/read/28106783/extract-of-polygala-tenuifolia-alleviates-stress-exacerbated-atopy-like-skin-dermatitis-through-the-modulation-of-protein-kinase-a-and-p38-mitogen-activated-protein-kinase-signaling-pathway
#5
Bongjun Sur, Bombi Lee, Ye Seul Yoon, Pooreum Lim, Riwon Hong, Mijung Yeom, Hyang Sook Lee, Hijoon Park, Insop Shim, Hyejung Lee, Young Pyo Jang, Dae-Hyun Hahm
Atopic dermatitis (AD) and stress create a vicious cycle: stress exacerbates atopic symptoms, and atopic disease elicits stress and anxiety. Targeting multiple pathways including stress and allergic inflammation is, therefore, important for treating AD. In this study, we investigated the remedial value of Polygala tenuifolia Willd. (PTW) for treating immobilization (IMO) stress-exacerbated atopy-like skin dermatitis and its underlying mechanism. Trimellitic anhydride (TMA) was applied to dorsal skin for sensitization and subsequently both ears for eliciting T-cell-dependent contact hypersensitivity in mice, which underwent 2 h-IMO stress and PTW administration for the latter 6 and 9 days in the ear exposure period of TMA, respectively...
January 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28105790/a-qualitative-study-of-patients-knowledge-and-views-of-about-oral-health-and-acceptability-of-related-intervention-in-an-australian-inpatient-alcohol-and-drug-treatment-facility
#6
Alison Li Sun Cheah, Ram Pandey, Mark Daglish, Pauline J Ford, Sue Patterson
Social factors, health behaviours and the direct effects of substances contribute to the poor oral health and restricted access to dental services experienced by people who are dependent on drugs and/or alcohol. Admission for inpatient withdrawal management provides an opportunity for intervention to promote oral health but to be effective it must be acceptable to patients. To support intervention design, we examined patients' views about oral health, practices and treatment access, and appropriateness of health-promoting intervention in this context...
January 20, 2017: Health & Social Care in the Community
https://www.readbyqxmd.com/read/28103056/age-related-changes-to-vascular-protease-activated-receptor-2-in-metabolic-syndrome-a-relationship-between-oxidative-stress-receptor-expression-and-endothelium-dependent-vasodilation
#7
Kana Maruyama, Satomi Kagota, John J McGuire, Hirokazu Wakuda, Noriko Yoshikawa, Kazuki Nakamura, Kazumasa Shinozuka
Protease-activated receptor 2 (PAR2) is expressed in vascular endothelium. Nitric oxide (NO) - cyclic GMP-mediated vasodilation in response to 2-furoyl-LIGRLO-amide (2fLIGRLO), a PAR2-activating peptide, is impaired in aortas from aged SHRSP.Z-Lepr(fa)/IzmDmcr (SHRSP.ZF) rats with metabolic syndrome. Here we investigated mechanisms linking PAR2's vascular effects to phenotypic characteristics of male SHRSP.ZF rats at 10, 20, and 30 weeks of age. We found vasodilation responses to either 2fLIGRLO or enzyme-mediated PAR2 activation by trypsin were sustained until 20 weeks and lessened at 30 weeks...
October 19, 2016: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28101344/evaluation-of-pharmacological-relaxation-effect-of-the-natural-product-naringin-on-in-vitro-cultured-airway-smooth-muscle-cells-and-in-vivo-ovalbumin-induced-asthma-balb-c-mice
#8
Yue Wang, Yun Lu, Mingzhi Luo, Xiaohao Shi, Yan Pan, Huilong Zeng, Linhong Deng
Asthma has become a common chronic respiratory disease worldwide and its prevalence is predicted to continue increasing in the next decade, particularly in developing countries. A key component in asthma therapy is to alleviate the excessive bronchial airway narrowing ultimately due to airway smooth muscle contraction, which is often facilitated by a smooth muscle relaxant, such as the β2-adrenergic agonists. Recently, bitter taste receptor (TAS2R) agonists, including saccharin and chloroquine, have been found to potently relax the airway smooth muscle cells (ASMCs) via intracellular Ca(2+) signaling...
December 2016: Biomedical Reports
https://www.readbyqxmd.com/read/28100852/allergenicity-of-milk-of-different-animal-species-in-relation-to-human-milk
#9
Robert Pastuszka, Joanna Barłowska, Zygmunt Litwińczuk
Protein content in cow milk (with over 20 proteins, and peptides may also occur as a result of enzymatic hydrolysis) ranges from 2.5% to 4.2% and is about 1.5-2 times higher than in human milk. Its most important allergens are considered to be β-lactoglobulin (absent in human milk) and αs1-casein. The most similar in composition to human milk is horse and donkey milk. It contains considerably more whey proteins (35-50%) than cow milk (about 20%), and the concentration of the most allergenic casein fraction αs1 is 1...
December 31, 2016: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/28100450/a-2-oxoglutarate-dependent-dioxygenase-mediates-the-biosynthesis-of-glucoraphasatin-in-radish
#10
Tomohiro Kakizaki, Hiroyasu Kitashiba, Zhongwei Zou, Feng Li, Nobuko Fukino, Takayoshi Ohara, Takeshi Nishio, Masahiko Ishida
Glucosinolates (GSLs) are secondary metabolites whose degradation products confer intrinsic flavors and aromas to Brassicaceae vegetables. Several structures of GSLs are known in the Brassicaceae, and the biosynthetic pathway and regulatory networks have been elucidated in Arabidopsis thaliana. GSLs are precursors of chemical defense substances against herbivorous pests. Specific GSLs can act as feeding blockers or stimulants, depending on the pest species. Natural selection has led to diversity in the GSL compositions even within individual species...
January 18, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28099526/executive-functioning-in-men-with-schizophrenia-and-substance-use-disorders-influence-of-lifetime-suicide-attempts
#11
Ana Adan, Maria Del Mar Capella, Gemma Prat, Diego A Forero, Silvia López-Vera, José Francisco Navarro
BACKGROUND: Lifetime suicide attempts in patients with comorbidity between psychotic disorders and Substance Use Disorder (SUD), known as dual diagnosis, was associated with a worse clinical and cognitive state, poor prognosis and premature death. However, to date no previous study has examined the cognitive performance of these patients considering as independent the presence or absence of lifetime suicide attempts. METHODS: We explore executive functioning differences between suicide attempters and non-attempters in dual schizophrenia (DS) patients and the possible related factors for both executive performance and current suicide risk...
2017: PloS One
https://www.readbyqxmd.com/read/28098840/comparative-solid-state-stability-of-perindopril-active-substance-vs-pharmaceutical-formulation
#12
Valentina Buda, Minodora Andor, Adriana Ledeti, Ionut Ledeti, Gabriela Vlase, Titus Vlase, Carmen Cristescu, Mirela Voicu, Liana Suciu, Mirela Cleopatra Tomescu
This paper presents the results obtained after studying the thermal stability and decomposition kinetics of perindopril erbumine as a pure active pharmaceutical ingredient as well as a solid pharmaceutical formulation containing the same active pharmaceutical ingredient (API). Since no data were found in the literature regarding the spectroscopic description, thermal behavior, or decomposition kinetics of perindopril, our goal was the evaluation of the compatibility of this antihypertensive agent with the excipients in the tablet under ambient conditions and to study the effect of thermal treatment on the stability of perindopril erbumine...
January 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28097536/prevalence-and-correlates-of-adhd-in-individuals-with-substance-use-disorder-in-nigeria
#13
Musa U Umar, Auwal S Salihu, Shakirat D Owolabi
Substance use disorder (SUD) is associated with ADHD. ADHD increases the severity of SUD and has negative influence on the prognosis of the disorder. The aim of the study was to determine the prevalence and correlates of ADHD in individuals with SUD. During 2013-2015, a cross-sectional descriptive study of 233 drug treatment-seeking individuals was assessed. Diagnosis of ADHD was done using DSM-IV criteria with the Diagnostic Interview for ADHD in Adults (DIVA 2.0), while Semi-structured Assessment for Drug Dependence and Alcoholism (SSADDA 6...
January 17, 2017: Attention Deficit and Hyperactivity Disorders
https://www.readbyqxmd.com/read/28096464/functional-transformation-of-c-reactive-protein-by-hydrogen-peroxide
#14
Sanjay K Singh, Avinash Thirumalai, Asmita Pathak, Donald N Ngwa, Alok Agrawal
C-reactive protein (CRP) is present at sites of inflammation including amyloid plaques, atherosclerotic lesions and arthritic joints. CRP, in its native pentameric structural conformation, binds to cells and molecules which have exposed phosphocholine (PCh) groups. CRP, in its non-native pentameric structural conformation, binds to a variety of deposited, denatured and aggregated proteins, in addition to binding to PCh-containing substances. In this study, we investigated the effects of hydrogen peroxide (H2O2), a prototypical reactive oxygen species and which is also present at sites of inflammation, on the ligand recognition function of CRP...
January 17, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28095182/effect-of-intermittent-aeration-on-microbial-diversity-in-an-intermittently-aerated-ifas-reactor-treating-municipal-wastewater-a-field-study
#15
Akansha Bhatia, Nitin Kumar Singh, Timsi Bhando, Ranjana Pathania, Absar Ahmad Kazmi
In the present study, the effect of three intermittent aeration (IA) cycles on treatment performance and microbial diversity was investigated in an integrated fixed film activated sludge (IFAS) reactor treating municipal wastewater. The results showed that IA strategies were able to achieve efficient removal of organics and nitrogen ranging between 90 and 95% and 70 and 80%, respectively, however the phosphorus removal was found to be inversely proportional to the duration of aeration off time in each IA cycle...
January 17, 2017: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/28094394/complete-ultrafast-charge-carrier-dynamics-in-photo-excited-all-inorganic-perovskite-nanocrystals-cspbx3
#16
Navendu Mondal, Anunay Samanta
Understanding the nature and dynamics of the photo-induced transients of all-inorganic perovskite nanocrystals (NCs) is key to their exploitation in potential applications. In order to determine the nature of charge carriers, their deactivation pathways and dynamics, the photo-induced transients of CsPbBr3, CsPbBr2I, CsPbBr1.5I1.5 and CsPbI3 NCs are spectrally and temporally characterized employing a combination of femtosecond transient absorption (TA) and photoluminescence (PL) up-conversion techniques and global analysis of the data...
January 17, 2017: Nanoscale
https://www.readbyqxmd.com/read/28093951/qualitative-comparison-of-polyethylene-terephthalate-flakes-from-various-collection-systems-in-germany
#17
H Snell, A Nassour, M Nelles
In 2003, a deposit system for one-way packaging was introduced in Germany. Since that time, polyethylene terephthalate beverage packaging is collected through various collection systems, a deposit system, a reusable packaging system and the 'Green Dot' (the dual system) with the yellow bag. The manner of collection had a decisive influence on the quality of the generated recycled materials. The research at hand shows for the first time how the quality of polyethylene terephthalate flakes depends on the type of collection system...
January 1, 2017: Waste Management & Research
https://www.readbyqxmd.com/read/28092954/modeling-and-simulation-for-toxicity-assessment
#18
Cristina Anton, Jian Deng, Yau Shu Wong, Yile Zhang, Weiping Zhang, Stephan Gabos, Dorothy Yu Huang, Can Jin
The effect of various toxicants on growth/death and morphology of human cells is investigated using the xCELLigence Real-Time Cell Analysis High Troughput in vitro assay. The cell index is measured as a proxy for the number of cells, and for each test substance in each cell line, time-dependent concentration response curves (TCRCs) are generated. In this paper we propose a mathematical model to study the effect of toxicants with various initial concentrations on the cell index. This model is based on the logistic equation and linear kinetics...
June 1, 2017: Mathematical Biosciences and Engineering: MBE
https://www.readbyqxmd.com/read/28092735/toxicity-assessment-of-arsenic-and-cobalt-in-the-presence-of-aquatic-humic-substances-of-different-molecular-sizes
#19
Cláudia Hitomi Watanabe, Adnivia Santos Costa Monteiro, Erik Sartori Jeunon Gontijo, Vivian Silva Lira, Carolina de Castro Bueno, Nirmal Tej Kumar, Renata Fracácio, André Henrique Rosa
The release of contaminants in aquatic ecosystems can be influenced by humic acids. In this study, toxicity tests using environmentally relevant concentrations of arsenic and cobalt were conducted both in the presence and absence of aquatic humic substances (AHS) and the fractions of different molecular sizes in the range of (<5, 5-10;10-30; 30-100 and >100kDa) using the microcrustacean Ceriodaphnia dubia. AHS together with arsenic reduced the toxicity, and the toxicity decreased in fractions of larger molecular size AHS...
January 13, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28092494/zebrafish-are-able-to-detect-ethanol-in-their-environment
#20
Steven Tran, Hayden Chow, Benjamin Tsang, Amanda Facciol, Prabhlene Gandhi, Priyanka Desai, Robert Gerlai
Zebrafish have become a popular animal model for studying the development of alcohol addiction. Several behavioral paradigms for studying alcohol addiction have been developed for zebrafish, including conditioned place preference, alcohol-induced tolerance, and withdrawal. However, alcohol choice preference tasks have not been established in zebrafish as of yet. The ability of zebrafish to detect alcohol in their environment is required in alcohol choice or preference tasks. To our knowledge, it is currently unknown whether zebrafish are able to detect alcohol in their environment immediately following bath immersion...
January 16, 2017: Zebrafish
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