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https://www.readbyqxmd.com/read/29329299/multi-drug-resistant-non-typhoidal-salmonella-associated-with-invasive-disease-in-western-kenya
#1
Adam Akullian, Joel M Montgomery, Grace John-Stewart, Samuel I Miller, Hillary S Hayden, Matthew C Radey, Kyle R Hager, Jennifer R Verani, John Benjamin Ochieng, Jane Juma, Jim Katieno, Barry Fields, Godfrey Bigogo, Allan Audi, Judd Walson
Non-typhoidal Salmonella (NTS) is a leading cause of bloodstream infections in Africa, but the various contributions of host susceptibility versus unique pathogen virulence factors are unclear. We used data from a population-based surveillance platform (population ~25,000) between 2007-2014 and NTS genome-sequencing to compare host and pathogen-specific factors between individuals presenting with NTS bacteremia and those presenting with NTS diarrhea. Salmonella Typhimurium ST313 and Salmonella Enteritidis ST11 were the most common isolates...
January 12, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29284476/why-some-sites-are-responding-better-to-anti-malarial-interventions-a-case-study-from-western-kenya
#2
Anthony Kapesa, Eliningaya J Kweka, Harrysone Atieli, Erasmus Kamugisha, Guofa Zhou, Andrew K Githeko, Guiyun Yan
BACKGROUND: In sub-Saharan Africa, malaria interventions over the last decades have been successful in reducing both mortality and morbidity. In western Kenya however some areas experience contrasting outcomes of the ongoing interventions while the causes for this observation remains not yet clearly known. METHODS: The WHO insecticide (deltamethrin) susceptibility test of the common malaria vectors was studied. Multiple surveys on household use and hospital prescriptions of antimalarial drugs from 2003 to 2015 were done...
December 29, 2017: Malaria Journal
https://www.readbyqxmd.com/read/29284003/identifying-cholera-hotspots-in-uganda-an-analysis-of-cholera-surveillance-data-from-2011-to-2016
#3
Godfrey Bwire, Mohammad Ali, David A Sack, Anne Nakinsige, Martha Naigaga, Amanda K Debes, Moise C Ngwa, W Abdullah Brooks, Christopher Garimoi Orach
BACKGROUND: Despite advance in science and technology for prevention, detection and treatment of cholera, this infectious disease remains a major public health problem in many countries in sub-Saharan Africa, Uganda inclusive. The aim of this study was to identify cholera hotspots in Uganda to guide the development of a roadmap for prevention, control and elimination of cholera in the country. METHODOLOGY/PRINCIPLE FINDINGS: We obtained district level confirmed cholera outbreak data from 2011 to 2016 from the Ministry of Health, Uganda...
December 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29283997/maternal-influenza-vaccine-strategies-in-kenya-which-approach-would-have-the-greatest-impact-on-disease-burden-in-pregnant-women-and-young-infants
#4
Meredith L McMorrow, Gideon O Emukule, David Obor, Bryan Nyawanda, Nancy A Otieno, Caroline Makokha, Joshua A Mott, Joseph S Bresee, Carrie Reed
BACKGROUND: Recent influenza surveillance data from Africa suggest an important burden of influenza-associated morbidity and mortality. In tropical countries where influenza virus transmission may not be confined to a single season alternative strategies for vaccine distribution via antenatal care (ANC) or semiannual campaigns should be considered. METHODS: Using data on monthly influenza disease burden in women of child-bearing age and infants aged 0-5 months in Kenya from 2010-2014, we estimated the number of outcomes (illnesses, medical visits, hospitalizations, and deaths) that occurred and that may have been averted through influenza vaccination of pregnant women using: 1) a year-round immunization strategy through ANC, 2) annual vaccination campaigns, and 3) semiannual vaccination campaigns...
2017: PloS One
https://www.readbyqxmd.com/read/29261766/characteristics-of-aedes-aegypti-adult-mosquitoes-in-rural-and-urban-areas-of-western-and-coastal-kenya
#5
Bryson Alberto Ndenga, Francis Maluki Mutuku, Harun Njenga Ngugi, Joel Omari Mbakaya, Peter Aswani, Peter Siema Musunzaji, John Vulule, Dunstan Mukoko, Uriel Kitron, Angelle Desiree LaBeaud
Aedes aegypti is the main vector for yellow fever, dengue, chikungunya and Zika viruses. Recent outbreaks of dengue and chikungunya have been reported in Kenya. Presence and abundance of this vector is associated with the risk for the occurrence and transmission of these diseases. This study aimed to characterize the presence and abundance of Ae. aegypti adult mosquitoes from rural and urban sites in western and coastal regions of Kenya. Presence and abundance of Ae. aegypti adult mosquitoes were determined indoors and outdoors in two western (urban Kisumu and rural Chulaimbo) and two coastal (urban Ukunda and rural Msambweni) sites in Kenya...
2017: PloS One
https://www.readbyqxmd.com/read/29162065/from-policy-to-practice-exploring-the-implementation-of-antiretroviral-therapy-access-and-retention-policies-between-2013-and-2016-in-six-sub-saharan-african-countries
#6
Julie Ambia, Jenny Renju, Alison Wringe, Jim Todd, Eveline Geubbels, Jessica Nakiyingi-Miiro, Mark Urassa, Tom Lutalo, Amelia C Crampin, Daniel Kwaro, Catherine Kyobutungi, Natsayi Chimbindi, F Xavier Gomez-Olive, Malebogo Tlhajoane, Brian Njamwea, Basia Zaba, Paul Mee
BACKGROUND: Understanding the implementation of 2013 World Health Organization (WHO) consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection at the facility level provides important lessons for the roll-out of future HIV policies. METHODS: A national policy review was conducted in six sub-Saharan African countries to map the inclusion of the 2013 WHO HIV treatment recommendations. Twenty indicators of policy adoption were selected to measure ART access (n = 12) and retention (n = 8)...
November 21, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/29141606/trends-in-bednet-ownership-and-usage-and-the-effect-of-bednets-on-malaria-hospitalization-in-the-kilifi-health-and-demographic-surveillance-system-khdss-2008-2015
#7
Alice Kamau, Victoria Nyaga, Evasius Bauni, Benjamin Tsofa, Abdisalan M Noor, Philip Bejon, J Anthony G Scott, Laura L Hammitt
BACKGROUND: Use of bednets reduces malaria morbidity and mortality. In Kilifi, Kenya, there was a mass distribution of free nets to children < 5 years in 2006. In 2009, a new policy was implemented to offer bednets to pregnant women and children < 5 years free of charge. Nets were again distributed to children and adults through national mass campaigns in 2012 and 2015. We aimed to evaluate trends in bednet ownership and usage, and the effect of bednets on the incidence of malaria hospitalization in children < 5 years within the Kilifi Health and Demographic Surveillance System (KHDSS)...
November 15, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29110670/indoor-and-outdoor-malaria-vector-surveillance-in-western-kenya-implications-for-better-understanding-of-residual-transmission
#8
Teshome Degefa, Delenasaw Yewhalaw, Guofa Zhou, Ming-Chieh Lee, Harrysone Atieli, Andrew K Githeko, Guiyun Yan
BACKGROUND: The widespread use of indoor-based malaria vector control interventions has been shown to alter the behaviour of vectors in Africa. There is an increasing concern that such changes could sustain residual transmission. This study was conducted to assess vector species composition, feeding behaviour and their contribution to indoor and outdoor malaria transmission in western Kenya. METHODS: Anopheles mosquito collections were carried out from September 2015 to April 2016 in Ahero and Iguhu sites, western Kenya using CDC light traps (indoor and outdoor), pyrethrum spray catches (PSCs) (indoor) and pit shelters (outdoor)...
November 6, 2017: Malaria Journal
https://www.readbyqxmd.com/read/29102168/impact-of-rotavirus-vaccine-on-rotavirus-diarrhoea-in-countries-of-east-and-southern-africa
#9
Goitom Weldegebriel, Jason M Mwenda, Jethro Chakauya, Fussum Daniel, Balcha Masresha, Umesh D Parashar, Jacqueline E Tate
BACKGROUND: Established in 2006 with four countries conducting hospital-based rotavirus surveillance, the African rotavirus surveillance network has expanded over subsequent years. By 2015, 14 countries in the World Health Organization (WHO) East and Southern Africa sub-region (Eritrea, Ethiopia, Kenya, Lesotho, Madagascar, Mauritius, Namibia, Rwanda, Seychelles, Swaziland, Tanzania, Uganda, Zambia and Zimbabwe) were participating in the rotavirus surveillance network coordinated by WHO...
October 25, 2017: Vaccine
https://www.readbyqxmd.com/read/29048283/unrecognized-dengue-virus-infections-in-children-western-kenya-2014-2015
#10
David M Vu, Noah Mutai, Claire J Heath, John M Vulule, Francis M Mutuku, Bryson A Ndenga, A Desiree LaBeaud
We detected a cluster of dengue virus infections in children in Kenya during July 2014-June 2015. Most cases were serotype 1, but we detected all 4 serotypes, including co-infections with 2 serotypes. Our findings implicate dengue as a cause of febrile illness in this population and highlight a need for robust arbovirus surveillance.
November 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29043592/factors-associated-with-surveillance-adenoma-and-sessile-serrated-polyp-detection-rates
#11
Jennifer K Maratt, Joseph Dickens, Philip S Schoenfeld, Grace H Elta, Kenya Jackson, Daniel Rizk, Christine Erickson, Stacy B Menees
BACKGROUND: Adenoma detection rate (ADR) and sessile serrated polyp detection rate (SSPDR) data in surveillance colonoscopy are limited. AIMS: Our aim was to determine surveillance ADR and SSPDR and identify associated predictors. METHODS: A retrospective review of subjects who underwent surveillance colonoscopy for adenoma and/or SSP at an academic center was performed. The following exclusion criteria were applied: prior colonoscopy ≤ 3 years, incomplete examination, or another indication for colonoscopy...
December 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28963171/implementing-maternal-death-surveillance-and-response-in-kenya-incremental-progress-and-lessons-learned
#12
Helen Smith, Charles Ameh, Pamela Godia, Judith Maua, Kigen Bartilol, Patrick Amoth, Matthews Mathai, Nynke van den Broek
Maternal death surveillance and response (MDSR) constitutes a quality improvement approach to identify how many maternal deaths occur, what the underlying causes of death and associated factors are, and how to implement actions to reduce the number of preventable stillbirths and maternal and neonatal deaths. This requires a coordinated approach, ensuring both national- and district-level stakeholders are enabled and supported and can implement MDSR in a "no name, no blame" environment. This field action report from Kenya provides an example of how MDSR can be implemented in a "real-life" setting by summarizing the experiences and challenges faced thus far by maternal death assessors and Ministry of Health representatives in implementing MDSR...
September 27, 2017: Global Health, Science and Practice
https://www.readbyqxmd.com/read/28959439/factors-associated-with-physical-violence-by-a-sexual-partner-among-girls-and-women-in-rural-kenya
#13
Deborah A Gust, Yi Pan, Fred Otieno, Tameka Hayes, Tereza Omoro, Penelope A Phillips-Howard, Fred Odongo, George O Otieno
BACKGROUND: Intimate partner physical violence increases women's risk for negative health outcomes and is an important public health concern. The purpose of the present study was to determine 1) the proportion of girls (≤18 years) and women (>18 years) who experienced physical violence by a sexual partner, and 2) factors (including self-reported HIV infection) associated with girls and women who experienced physical violence by a sexual partner. METHODS: Cross-sectional surveys conducted in the Gem Health and Demographic Surveillance System (HDSS) area in Siaya County, western Kenya in 2011-2012 (Round 1) and 2013-2014 (Round 2)...
December 2017: Journal of Global Health
https://www.readbyqxmd.com/read/28883972/molecular-characterization-and-antibiotic-resistance-profiles-of-salmonella-isolated-from-fecal-matter-of-domestic-animals-and-animal-products-in-nairobi
#14
Diana Nyabundi, Nyamongo Onkoba, Rinter Kimathi, Atunga Nyachieo, Gerald Juma, Peter Kinyanjui, Joseph Kamau
BACKGROUND: Salmonella has significant public health implications causing food borne and zoonotic diseases in humans. Treatment of infections due to Salmonella is becoming difficult due to emergence of drug resistant strains. There is therefore need to characterize the circulating non-typhoidal Salmonella (NTS) serovars in domestic animals and animal products in Kenya as well as determine their antibiotic resistance profiles. METHODS: A total of 740 fecal samples were collected from cows (n = 150), pigs (n = 182), chicken (n = 191) and chicken eggs (n = 217) from various markets and abattoirs in Nairobi...
2017: Tropical Diseases, Travel Medicine and Vaccines
https://www.readbyqxmd.com/read/28877208/surveillance-for-falsified-and-substandard-medicines-in-africa-and-asia-by-local-organizations-using-the-low-cost-gphf-minilab
#15
Albert Petersen, Nadja Held, Lutz Heide
BACKGROUND: Substandard and falsified medical products present a serious threat to public health, especially in low- and middle-income countries. Their identification using pharmacopeial analysis is expensive and requires sophisticated equipment and highly trained personnel. Simple, low-cost technologies are required in addition to full pharmacopeial analysis in order to accomplish widespread routine surveillance for poor-quality medicines in low- and middle-income countries. METHODS: Ten faith-based drug supply organizations in seven countries of Africa and Asia were each equipped with a Minilab of the Global Pharma Health Fund (GPHF, Frankfurt, Germany), suitable for the analysis of about 85 different essential medicines by thin-layer chromatography...
2017: PloS One
https://www.readbyqxmd.com/read/28813542/the-african-cholera-surveillance-network-africhol-consortium-meeting-10-11-june-2015-lom%C3%A3-togo
#16
Aline Munier, Berthe-Marie Njanpop-Lafourcade, Delphine Sauvageot, Raymond B Mhlanga, Léonard Heyerdahl, Johara Nadri, Richard Wood, Issaka Ouedraogo, Alexandre Blake, Laurent Akilimali Mukelenge, Jean-Claude B Anné, Abiba Banla Kere, Lucienne Dempouo, Sakoba Keita, José P M Langa, Issa Makumbi, Elibariki R Mwakapeje, Ian J Njeru, Olubunmi E Ojo, Isaac Phiri, Lorenzo Pezzoli, Bradford D Gessner, Martin Mengel
The fifth annual meeting of the African cholera surveillance network (Africhol) took place on 10-11 June 2015 in Lomé, Togo. Together with international partners, representatives from the 11 member countries -Cameroon, Côte d'Ivoire, Democratic Republic of Congo, Guinea, Kenya, Mozambique, Nigeria, Tanzania, Togo, Uganda, Zimbabwe- and an invited country (Malawi) shared their experience. The meeting featured three sessions: i) cholera surveillance, prevention and control in participating countries, ii) cholera surveillance methodology, such as cholera mapping, cost-effectiveness studies and the issue of overlapping epidemics from different diseases, iii) cholera laboratory diagnostics tools and capacity building...
2017: BMC Proceedings
https://www.readbyqxmd.com/read/28780116/impact-of-rotavirus-vaccination-on-rotavirus-and-all-cause-gastroenteritis-in-peri-urban-kenyan-children
#17
Ernest Apondi Wandera, Shah Mohammad, Martin Bundi, Satoshi Komoto, James Nyangao, Cyrus Kathiiko, Erick Odoyo, Gabriel Miring'u, Koki Taniguchi, Yoshio Ichinose
A monovalent rotavirus vaccine (RV1) was introduced into the National Immunization Program in Kenya in July 2014. We examined the impact of the vaccine on hospitalization for all-cause acute gastroenteritis (AGE) and rotavirus-specific AGE and strain distribution at a large referral hospital which serves a predominantly peri-urban population in Central Kenya. Data on rotavirus AGE and strain distribution were derived from ongoing hospital-based AGE surveillance. Hospital administrative data were used to compare trends in all-cause AGE...
August 2, 2017: Vaccine
https://www.readbyqxmd.com/read/28774694/improvement-of-fungal-disease-identification-and-management-combined-health-systems-and-public-health-approaches
#18
REVIEW
Donald C Cole, Nelesh P Govender, Arunaloke Chakrabarti, Jahit Sacarlal, David W Denning
More than 1·6 million people are estimated to die of fungal diseases each year, and about a billion people have cutaneous fungal infections. Fungal disease diagnosis requires a high level of clinical suspicion and specialised laboratory testing, in addition to culture, histopathology, and imaging expertise. Physicians with varied specialist training might see patients with fungal disease, yet it might remain unrecognised. Antifungal treatment is more complex than treatment for bacterial or most viral infections, and drug interactions are particularly problematic...
July 31, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28767714/hiv-associated-mortality-in-the-era-of-antiretroviral-therapy-scale-up-nairobi-kenya-2015
#19
Peter W Young, Andrea A Kim, Joyce Wamicwe, Lilly Nyagah, Catherine Kiama, John Stover, Johansen Oduor, Emily A Rogena, Edwin Walong, Emily Zielinski-Gutierrez, Andrew Imbwaga, Martin Sirengo, Timothy A Kellogg, Kevin M De Cock
BACKGROUND: Declines in HIV prevalence and increases in antiretroviral treatment coverage have been documented in Kenya, but population-level mortality associated with HIV has not been directly measured. In urban areas where a majority of deaths pass through mortuaries, mortuary-based studies have the potential to contribute to our understanding of excess mortality among HIV-infected persons. We used results from a cross-sectional mortuary-based HIV surveillance study to estimate the association between HIV and mortality for Nairobi, the capital city of Kenya...
2017: PloS One
https://www.readbyqxmd.com/read/28736393/traditional-healers-faith-healers-and-medical-practitioners-the-contribution-of-medical-pluralism-to-bottlenecks-along-the-cascade-of-care-for-hiv-aids-in-eastern-and-southern-africa
#20
MULTICENTER STUDY
Mosa Moshabela, Dominic Bukenya, Gabriel Darong, Joyce Wamoyi, Estelle McLean, Morten Skovdal, William Ddaaki, Kenneth Ondeng'e, Oliver Bonnington, Janet Seeley, Victoria Hosegood, Alison Wringe
OBJECTIVES: There are concerns that medical pluralism may delay patients' progression through the HIV cascade-of-care. However, the pathways of impact through which medical pluralism influence the care of people living with HIV (PLHIV) in African settings remain unclear. We sought to establish the manifestation of medical pluralism among PLHIV, and explore mechanisms through which medical pluralism contributes bottlenecks along the HIV care cascade. METHODS: We conducted a multicountry exploratory qualitative study in seven health and demographic surveillance sites in six eastern and southern African countries: Uganda, Kenya, Tanzania, Malawi, Zimbabwe and South Africa...
July 2017: Sexually Transmitted Infections
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