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https://www.readbyqxmd.com/read/29792114/innovating-urinary-catheter-design-an-introduction-to-the-engineering-challenge
#1
Cathy Murphy
Every day, people around the world rely on intermittent and indwelling urinary catheters to manage bladder dysfunction, but the potential or actual harm caused by these devices is well-recognised. Current catheter designs can cause urinary tract infection and septicaemia, bladder and urethral trauma and indwelling devices frequently become blocked. Furthermore, the devices can severely disrupt users' lives, limiting their daily activities and can be costly to manage for healthcare providers. Despite this, little significant design innovation has taken place in the last 80 years...
May 1, 2018: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/29789918/recent-experience-and-follow-up-after-surgical-closure-of-secundum-atrial-septal-defect-in-120-children
#2
Geoffroy de Beco, Natasha Mambour, Christophe Vô, Laetitia Vanhoutte, Stéphane Moniotte, Alain Poncelet, Thierry Sluysmans
While percutaneous catheter closure proves an effective treatment for secundum atrial septal defect (ASD2), some child patients require surgical closure. We assessed the risks associated with isolated surgical ASD2 closure by reviewing the outcomes of 120 children operated on between 1999 and 2011 (mean age 4.6 ± 3.9 years, mean weight 17 ± 12 kg). Direct sutures were performed in 4% and patch closures in 96%. The mean cardiopulmonary bypass duration was 38 ± 14 min, aortic cross-clamp time 19 ± 9 min, intensive care unit length of stay 1...
May 22, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29788897/biofilm-destruction-on-endotracheal-tube-associated-pneumonia-by-photodynamic-inactivation
#3
Kate Cristina Blanco, Amanda C Zangirolami, Natalia M Inada, Vanderlei S Bagnato
Hospital infections is a public health problem that can occur with the use of catheters and endotracheal tubes (ETT). Pathogenic microorganisms may adhere to surfaces of these materials forming biofilm. Microbial biofilms presents an extracellular polymer matrix that promotes resistance of microorganisms to factors such as pH, temperature and drugs. The ETT is used to assist a patient with compromised breathing function. ETT biofilm may cause ventilator-associated pneumonia. Pseudomonas aeruginosa and Staphylococcus aureus pneumonia is associated with a 21-fold increase in risk for mechanical ventilation...
May 22, 2018: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/29788198/venous-thromboembolism-after-intraventricular-hemorrhage-results-from-the-clear-iii-trial
#4
(no author information available yet)
BACKGROUND: Venous thromboembolism (VTE) after intracerebral hemorrhage is well studied, but data on patients with spontaneous intraventricular hemorrhage (IVH) are limited. OBJECTIVE: To study the factors associated with VTE, association between VTE and clinical outcomes in IVH, and safety of VTE chemoprophylaxis in IVH treated with intraventricular catheters and thrombolysis. METHODS: Retrospective cohort study of patients enrolled in the CLEAR III trial, a multicenter, randomized trial comparing external ventricular drainage, with administration of intraventricular alteplase vs placebo, for obstructive IVH...
May 21, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29788118/risk-factors-for-treatment-failure-and-mortality-among-hospitalised-patients-with-complicated-urinary-tract-infection-a-multicentre-retrospective-cohort-study-rescuing-study-group
#5
Noa Eliakim-Raz, Tanya Babitch, Evelyn Shaw, Ibironke Addy, Irith Wiegand, Christiane Vank, Laura Torre-Vallejo, Vigo Joan-Miquel, Morris Steve, Sally Grier, Margaret Stoddart, Cuperus Nienke, Leo van den Heuvel, Cuong Vuong, Alasdair MacGowan, Jordi Carratalà, Leonard Leibovici, Miquel Pujol
Background: Complicated urinary tract infections (cUTIs) are responsible for a major share of all antibiotic consumption in hospitals. We aim to describe risk factors for treatment failure and mortality among hospitalised patients with cUTIs. Methods: A multinational, multicentre retrospective cohort study, conducted in 20 countries in Europe and the Middle East. Data were collected from patients' files on hospitalised patients with a diagnosis of cUTI during 2013-2014...
May 17, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29785872/effect-evaluation-on-use-of-bedside-fiber-bronchoscope-in-treating-stroke-associated-pneumonia
#6
Qiu Han, Chun Chen, Hai-Qin Hu, Jun Shen, Guang Yang, Bin Chen, Lei Xia
Background The bedside fiber bronchoscope has been widely used in the diagnosis and treatment of respiratory disease. This study aims to assess the effect of using bedside fiber bronchoscope in sputum suction and alveolar lavage for treatment of stroke-associated pneumonia (SAP), compared with the use of conventional suction catheter. Methods One hundred and six patients with SAP were randomly divided into control group (n = 53) and experimental group (n = 53) for a controlled study. Patients in the two groups were conventionally treated with phlegm-resolving and anti-infective therapy...
May 22, 2018: Topics in Stroke Rehabilitation
https://www.readbyqxmd.com/read/29785307/a-review-of-percutaneous-transluminal-angioplasty-in-hemodialysis-fistula
#7
REVIEW
Ioannis Bountouris, Georgia Kritikou, Nikolaos Degermetzoglou, Konstantinos Ioannis Avgerinos
The number of patients in dialysis increases every year. In this review, we will evaluate the role of percutaneous transluminal angioplasty (PTA) according to patency of arteriovenous fistula and grafts. The main indication of PΤΑ is stenosis > 50% or obstruction of the vascular lumen of an arteriovenous fistula and graft. It is usually performed under local anesthesia. The infection rate is as low as the number of complications. Fistula can be used in dialysis in the same day without the need for a central venous catheter...
2018: International Journal of Vascular Medicine
https://www.readbyqxmd.com/read/29784475/post-fabrication-qac-functionalized-thermoplastic-polyurethane-for-contact-killing-catheter-applications
#8
Zachary K Zander, Peiru Chen, Yen-Hao Hsu, Nathan Z Dreger, Laura Savariau, Willie C McRoy, Alec E Cerchiari, Sean D Chambers, Hazel A Barton, Matthew L Becker
The use of catheters is ubiquitous in medicine and the incidence of infection remains unacceptably high despite numerous advances in functional surfaces and drug elution. Herein we report the use of a thermoplastic polyurethane containing an allyl ether side-chain functionality (allyl-TPU) that allows for rapid and convenient surface modification with antimicrobial reagents, post-processing. This post-processing functionalization affords the ability to target appropriate TPU properties and maintain the functional groups on the surface of the device where they do not affect bulk properties...
May 11, 2018: Biomaterials
https://www.readbyqxmd.com/read/29780757/huge-candida-albicans-normal-native-tricuspid-valve-endocarditis
#9
Massimiliano Guerriero, Francesco Colasurdo, Anna Maria Pollio
Fungal endocarditis has become an important infection associated with medical progress and the modern lifestyle. In particular, Candida spp. is a rare but important cause of infective endocarditis. We report the case of a 28-year-old woman-quadriplegic and bedridden from birth-who died after repeated episodes of pneumonia treated with different regimens of intravenous antibiotics. A medico legal autopsy was performed, which diagnosed severe Candida native valve infective endocarditis (CIE). This case report illustrates the prolonged use of antibiotic treatment as a possible risk factor for the development of CIE...
April 2018: Autopsy & Case Reports
https://www.readbyqxmd.com/read/29779995/factors-predicting-postoperative-febrile-urinary-tract-infection-following-percutaneous-nephrolithotomy-in-prepubertal-children
#10
Onur Kaygısız, Nihat Satar, Ali Güneş, Hasan Serkan Doğan, Ahmet Erözenci, Ender Özden, Mehmet Mesut Pişkin, Deniz Demirci, Serdar Toksöz, Tufan Çiçek, Serhat Gürocak, Hakan Kılıçarslan, Oktay Nazlı, Aykut Kefi, Volkan İzol, Ali Beytur, Şaban Sarıkaya, Serdar Tekgül, Bülent Önal
BACKGROUND: Predictive tables and scoring systems can predict stone clearance. However, there is a paucity of evidence regarding the prediction of complications during percutaneous nephrolithotomy (PCNL), particularly in children, which remains under-researched. To our knowledge, no studies have evaluated the risk factors for febrile urinary tract infection (FUTI) after pediatric PCNL. OBJECTIVES: To assess the predictive factors of FUTI in prepubertal children after PCNL and determine whether any prophylactic cephalosporins are superior for decreasing the FUTI rate...
May 5, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29779689/prevalence-of-infections-and-antimicrobial-prescribing-in-australian-aged-care-facilities-evaluation-of-modifiable-and-nonmodifiable-determinants
#11
Bennett Noleen, Nabeel Imam, Rodney James, Caroline Chen, Ann Bull, Karin Thursky, Kirsty Buising, Leon Worth
BACKGROUND: Infections in aged care residents are associated with poor outcomes, and inappropriate antimicrobial prescribing contributes to adverse events, such as the emergence of antimicrobial resistance. The objective of this study was to identify resident- and facility-level factors associated with infection and antimicrobial prescribing in Australian aged care residents. METHODS: Using data captured by a national point-prevalence survey (the Aged Care National Antimicrobial Prescribing Survey), risk and protective factors were determined by multivariate Poisson regression...
May 17, 2018: American Journal of Infection Control
https://www.readbyqxmd.com/read/29778510/assessment-of-intestinal-failure-associated-liver-disease-according-to-different-diagnostic-criteria
#12
Anna Simona Sasdelli, Federica Agostini, Caterina Pazzeschi, Mariacristina Guidetti, Simon Lal, Loris Pironi
BACKGROUND & AIMS: Intestinal failure associated liver disease (IFALD) has been defined using numerous criteria; however the clinical relevance of these criteria has never been compared. We therefore aimed to evaluate the prevalence, incidence, evolution of IFALD diagnosed by different criteria and to assess any clinical features that may be associated with its occurrence. METHODS: A cross sectional (CS) and retrospective study were carried out on adults on home parenteral nutrition (HPN) for chronic intestinal failure (CIF) managed at a single center...
May 8, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29778436/enhanced-central-venous-catheter-bundle-for-pediatric-parenteral-dependent-intestinal-failure
#13
Jennifer A Ormsby, Bola Bukoye, Debra Lajoie, Herminia Shermont, Lisa Martin, Kierrah Leger, Judy Mahoney, Gail Potter-Bynoe, Jane Carpenter, Al Ozonoff, Grace M Lee
BACKGROUND: Central line-associated bloodstream infections (CLABSIs) cause substantial morbidity and increase antimicrobial use and length of stay among hospitalized children in the United States. CLABSI occurs more frequently among high-risk pediatric patients, such as those with intestinal failure (IF) who are parenteral nutrition (PN) dependent. Following an increase in CLABSI rates, a quality improvement (QI) initiative was implemented. METHODS: Using QI methodology, an enhanced central venous catheter (CVC) maintenance bundle was developed and implemented on 2 units for pediatric PN-dependent patients with IF...
May 16, 2018: American Journal of Infection Control
https://www.readbyqxmd.com/read/29778430/does-periurethral-cleaning-with-water-prior-to-indwelling-urinary-catheterization-increase-the-risk-of-urinary-tract-infections-a-systematic-review-and-meta-analysis
#14
REVIEW
Kun Huang, Jihong Liang, Ting Mo, Yanli Zhou, Yanping Ying
OBJECTIVE: To determine whether periurethral cleaning with water before indwelling urinary catheterization increases the risk of urinary tract infections (UTIs) compared with studies using anti-infective agents. METHODS: A literature search via MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials through October 2017 and a manual search of references for additional relevant studies. Trials studying clean intermittent catheterization were excluded...
May 16, 2018: American Journal of Infection Control
https://www.readbyqxmd.com/read/29777282/ambulatory-intravenous-inotropic-support-and-or-levosimendan-in-pediatric-and-congenital-heart-failure-safety-survival-improvement-or-transplantation
#15
Sotiria C Apostolopoulou, George A Vagenakis, Alexandros Tsoutsinos, Felicia Kakava, Spyridon Rammos
End-stage heart failure (HF) frequently needs continuous inotropic support in hospital and has high morbidity and mortality in absence of heart transplantation. This study reports outcome, efficacy, and safety of continuous ambulatory inotropes (AI) and/or periodic levosimendan (LS) infusions in pediatric HF patients. The study included 27 patients, median age 9.4 (0.1-26.1) years, with severe HF (6 myocarditis, 13 dilated cardiomyopathy, 2 restrictive cardiomyopathy, 6 repaired congenital heart disease). Dobutamine and milrinone AI were administered in 21 patients through a permanent central catheter for median duration 1...
May 18, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29773661/phase-i-study-of-oncolytic-vaccinia-virus-gl-onc1-in-patients-with-peritoneal-carcinomatosis
#16
Ulrich M Lauer, Martina Schell, Julia Beil, Susanne Berchtold, Ursula Koppenhöfer, Jörg Glatzle, Alfred Königsrainer, Robert Möhle, Dominik Nann, Falko Fend, Christina Pfannenberg, Michael Bitzer, Nisar P Malek
OBJECTIVE: Peritoneal carcinomatosis (PC) is common in advanced tumor stages or disease recurrence arising from gastrointestinal cancers, gynecologic malignancies, or primary peritoneal carcinoma. Since current therapies are mostly ineffective, new thera-peutic approaches are needed. Here, we report on a phase I study designed to assess safety, MTD, and anti-tumor activity of intra-peri-toneal (i.p.) administration of oncolytic vaccinia virus GL-ONC1 in advanced stage PC patients. DESIGN: GL-ONC1 was administered i...
May 17, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29772402/serious-adverse-events-following-normal-pressure-hydrocephalus-surgery
#17
Vikas Kotagal, Elizabeth Walkowiak, Jason A Heth
OBJECTIVE: Recent Normal Pressure Hydrocephalus (NPH) practice guidelines describe a serious adverse event (SAE) rate following surgery of 11%. PATIENTS & METHODS: We conducted a retrospective review of 162 consecutive patients who have undergone work-up at our center's multidisciplinary NPH clinic over a 47 month time period (2/2014-12/2017). Of these, 22 ultimately underwent neurosurgical ventricular shunt surgery as treatment for NPH. Clinical records were reviewed for SAEs categorized as possibly/probably/definitely related to NPH surgery...
May 14, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29772359/bilateral-external-ventricular-drains-increase-ventriculostomy-associated-cerebrospinal-fluid-infection-in-low-modified-graeb-score-intraventricular-hemorrhage
#18
Zheng Wen-Jian, L I Liang-Ming, Hu Zi-Hui, Liao Wei, Lin Qi-Chang, Zhu Yong-Hua, Lin Shao-Hua
BACKGROUND: Ventriculostomy-associated cerebrospinal fluid infection (VAI) is a major complication limiting the use of an external ventricular drain (EVD) in intraventricular hemorrhage (IVH). Risk factors of VAI are still under wide discussion. METHODS: We performed a retrospective review of 84 IVH patients who underwent EVD at our center between January 2012 and January 2017. Preoperative clinical parameters, surgeon status, number of catheters and catheter-days, subgaleal tunneling distance, frequency of urokinase flush, and prophylactic antibiotics were compared between the infective and non-infective groups...
May 14, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29771360/patient-and-treatment-characteristics-by-infecting-organism-in-cerebrospinal-fluid-shunt-infection
#19
Tamara D Simon, Matthew P Kronman, Kathryn B Whitlock, Samuel R Browd, Richard Holubkov, John R W Kestle, Abhaya V Kulkarni, Marcie Langley, David D Limbrick, Thomas G Luerssen, Jerry Oakes, Jay Riva-Cambrin, Curtis Rozzelle, Chevis N Shannon, Mandeep Tamber, John C Wellons Iii, William E Whitehead, Nicole Mayer-Hamblett
Background: Previous studies of cerebrospinal fluid (CSF) shunt infection treatment have been limited in size and unable to compare patient and treatment characteristics by infecting organism. Our objective was to describe variation in patient and treatment characteristics for children with first CSF shunt infection, stratified by infecting organism subgroups outlined in the 2017 Infectious Disease Society of America's (IDSA) guidelines. Methods: We studied a prospective cohort of children <18 years of age undergoing treatment for first CSF shunt infection at one of 7 Hydrocephalus Clinical Research Network hospitals from April 2008 to December 2012...
May 15, 2018: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29771236/can-dalbavancin-be-used-as-a-catheter-lock-solution
#20
Cristina Díaz-Ruíz, Beatriz Alonso, Emilia Cercenado, Raquel Cruces, Emilio Bouza, Patricia Muñoz, María Guembe
PURPOSE: The new lipoglycopeptide dalbavancin has only been approved for acute bacterial skin and skin structure infections. However, its alternative use as a catheter lock solution could facilitate the conservative management of catheter-related bloodstream infection. Our objective was to assess the stability and activity of dalbavancin alone and in combination with heparin against methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant Staphylococcus epidermidis (MRSE) biofilms...
May 17, 2018: Journal of Medical Microbiology
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