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Judith M Ford, Brian J Roach, Vanessa A Palzes, Daniel H Mathalon
Perceptional abnormalities in schizophrenia are associated with hallucinations and delusions, but also with negative symptoms and poor functional outcome. Perception can be studied using EEG-derived event related potentials (ERPs). Because of their excellent temporal resolution, ERPs have been used to ask when perception is affected by schizophrenia. Because of its excellent spatial resolution, functional magnetic resonance imaging (fMRI) has been used to ask where in the brain these effects are seen. We acquired EEG and fMRI data simultaneously to explore when and where auditory perception is affected by schizophrenia...
2016: NeuroImage: Clinical
Sreenath Kyathanahally, Ana Franco-Watkins, Xiaoxia Zhang, Vince Calhoun, Gopikrishna Deshpande
Human decision-making is a multidimensional construct, driven by a complex interplay between external factors, internal biases and computational capacity constraints. Here we propose a layered approach to experimental design in which multiple tasks - from simple to complex - with additional layers of complexity introduced at each stage, are incorporated for investigating decision-making. This is demonstrated using tasks involving intertemporal choice between immediate and future prospects. Previous functional magnetic resonance imaging (fMRI) and electroencephalographic (EEG) studies have separately investigated the spatial and temporal neural substrates, respectively, of specific factors underlying decision making...
July 12, 2016: IEEE Journal of Biomedical and Health Informatics
Karl Magtibay, Mohammadali Beheshti, Farbod Hosseyndoust Foomany, Stéphane Massé, Patrick F H Lai, Nima Zamiri, John Asta, Kumaraswamy Nanthakumar, David Jaffray, Sridhar Krishnan, Karthikeyan Umapathy
Current practices in studying cardiac arrhythmias primarily use electrical or optical surface recordings of a heart, spatially limited transmural recordings, and mathematical models. However, given that such arrhythmias occur on a 3D myocardial tissue, information obtained from such practices lack in dimension, completeness, and are sometimes prone to oversimplification. The combination of complementary Magnetic-Resonance Imaging (MRI)-based techniques such as Current Density Imaging (CDI) and Diffusion Tensor Imaging (DTI) could provide more depth to current practices in assessing the cardiac arrhythmia dynamics in entire cross sections of myocardium...
May 1, 2016: Computers in Biology and Medicine
Pauline Soh, Balaji Narayanan, Sabin Khadka, Vince D Calhoun, Matcheri S Keshavan, Carol A Tamminga, John A Sweeney, Brett A Clementz, Godfrey D Pearlson
BACKGROUND: Many studies have examined either electroencephalogram (EEG) frequency activity or gray matter volumes (GMV) in various psychoses [including schizophrenia (SZ), schizoaffective (SZA), and psychotic bipolar disorder (PBP)]. Prior work demonstrated similar EEG and gray matter abnormalities in both SZ and PBP. Integrating EEG and GMV and jointly analyzing the combined data fully elucidates the linkage between the two and may provide better biomarker- or endophenotype-specificity for a particular illness...
2015: Frontiers in Psychiatry
Jonathan K Wynn, Amy M Jimenez, Brian J Roach, Alexander Korb, Junghee Lee, William P Horan, Judith M Ford, Michael F Green
Schizophrenia patients have abnormal neural responses to salient, infrequent events. We integrated event-related potentials (ERP) and fMRI to examine the contributions of the ventral (salience) and dorsal (sustained) attention networks to this dysfunctional neural activation. Twenty-one schizophrenia patients and 22 healthy controls were assessed in separate sessions with ERP and fMRI during a visual oddball task. Visual P100, N100, and P300 ERP waveforms and fMRI activation were assessed. A joint independent components analysis (jICA) on the ERP and fMRI data were conducted...
2015: NeuroImage: Clinical
Takesumi Yoshimura
During my academic career for more than 40 years, I was involved in 18 epidemiological field studies, partially or fully. Among these field studies, four (1. Medical services in remote rural areas in Okinawa, 2. Yusho episode, 3. JICA Onchocerciasis Control Project in Guatemala, and 4. Miyako cohort study in Fukuoka) are introduced in this paper, including the latest situation after the presentation. Through these field works experienced by the author, the following lessons were gained. 1. Strong human reliance between researchers and the targeted population is essential in carrying out epidemiological surveys successfully in the field...
2015: Nihon Eiseigaku Zasshi. Japanese Journal of Hygiene
Motoyuki Yuasa, Yoshihisa Shirayama, Keiichi Osato, Cesar Miranda, Julia Condore, Roxana Siles
BACKGROUND: An assessment of self-efficacy and social capital may have the potential to detect an effect of dynamic, complex and comprehensive collective actions in community-based health promotion. In 2003, a healthy village project was launched in Santa Cruz, Bolivia with technical assistance from the Japan International Cooperation Agency (JICA). The originally developed FORSA (Fortalecimiento de Redes de Salud) model accounted for participatory processes in which people could improve their health and well-being through individual behavioral changes and family/community-driven activities...
2015: BMC International Health and Human Rights
Seung-Goo Kim, Wi Hoon Jung, Sung Nyun Kim, Joon Hwan Jang, Jun Soo Kwon
Many of previous neuroimaging studies on neuronal structures in patients with obsessive-compulsive disorder (OCD) used univariate statistical tests on unimodal imaging measurements. Although the univariate methods revealed important aberrance of local morphometry in OCD patients, the covariance structure of the anatomical alterations remains unclear. Motivated by recent developments of multivariate techniques in the neuroimaging field, we applied a fusion method called "mCCA+jICA" on multimodal structural data of T1-weighted magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) of 30 unmedicated patients with OCD and 34 healthy controls...
2015: PloS One
Mahdi Ramezani, Purang Abolmaesumi, Amir Tahmasebi, Rachael Bosma, Ryan Tong, Tom Hollenstein, Kate Harkness, Ingrid Johnsrude
Computational neuroanatomical techniques that are used to evaluate the structural correlates of disorders in the brain typically measure regional differences in gray matter or white matter, or measure regional differences in the deformation fields required to warp individual datasets to a standard space. Our aim in this study was to combine measurements of regional tissue composition and of deformations in order to characterize a particular brain disorder (here, major depressive disorder). We use structural Magnetic Resonance Imaging (MRI) data from young adults in a first episode of depression, and from an age- and sex-matched group of non-depressed individuals, and create population gray matter (GM) and white matter (WM) tissue average templates using DARTEL groupwise registration...
2015: NeuroImage: Clinical
K Magtibay, M Beheshti, F H Foomany, K Balasundaram, S Masse, P Lai, J Asta, N Zamiri, D A Jaffray, K Nanthakumar, S Krishnan, K Umapathy
Magnetic Resonance Imaging (MRI) techniques such as Current Density Imaging (CDI) and Diffusion Tensor Imaging (DTI) provide a complementing set of imaging data that can describe both the functional and structural states of biological tissues. This paper presents a Joint Independent Component Analysis (jICA) based fusion approach which can be utilized to fuse CDI and DTI data to quantify the differences between two cardiac states: Ventricular Fibrillation (VF) and Asystolic/Normal (AS/NM). Such an approach could lead to a better insight on the mechanism of VF...
2014: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
M Ramezani, K Marble, H Trang, I S Johnsrude, P Abolmaesumi
A single-task functional magnetic resonance imaging (fMRI) experiment may only partially highlight alterations to functional brain networks affected by a particular disorder. Multivariate analysis across multiple fMRI tasks may increase the sensitivity of fMRI-based diagnosis. Prior research using multi-task analysis in fMRI, such as those that use joint independent component analysis (jICA), has mainly assumed that brain activity patterns evoked by different tasks are independent. This may not be valid in practice...
January 2015: IEEE Transactions on Medical Imaging
Eiji Ido, Shoji Yamaoka
Ghana-Tokyo Medical and Dental University Research Collaboration Center has been established since 2008 when our Program was chosen together with the Program in the Philippines proposed by Tohoku University as an additional small-scale research center of the Overseas Research Program on Emerging and Reemerging Diseases that is funded by the Ministry of Education, Culture, Sports, Science and Technology of the Japanese Government and started in 2005. This 5-year government-supported Program has changed its name to develop into a more active world-level program called Japan Initiative for Global Research Network on Infectious Diseases (J-GRID) and entered the second 5-year phase in 2010, and our Program is playing an important role among other research centers located in Asia and Africa...
2013: Uirusu
Yoshio Ichinose
The Institute of Tropical Medicine, Kenya Research Station, Nagasaki University was established by a fund of the Ministry of Education (MEXT) in 2005. Currently, the station has been on ''The Clinical and Epidemiological Research Program of Tropical Medicine and Emerging Infectious Diseases-Establishment of Education and Research System between Africa and Japan- ''. The project has been supported by about 20 Japanese staff and 85 Kenyan staff, and in the research station, 10 research teams have worked on their researches for the prevention of tropical medicine and emerging diseases collaborating with other researches and The JICA Grassroots Technical Cooperation Project has also started in 2012...
2013: Uirusu
Takako Utsumi, Yoshitake Hayashi, Hak Hotta
Kobe-Indonesia Collaborative Research Center was established in Institute of Tropical Disease (ITD), Airlangga University, Surabaya, Indonesia in 2007 under the program of ''Founding Research Centers for Emerging and Reemerging Infectious Diseases'' supported by the Ministry of Education, Culture, Sports, Science and Technology, Japan, and then it has been under the Japan Initiative for Global Research Network on Infectious Diseases (J-GRID) since 2010. Japanese researchers have been stationed at ITD, conducting joint researches on influenza, viral hepatitis, dengue and infectious diarrhea...
2013: Uirusu
Masanori Kameoka, Tadahiro Sasaki
Thailand-Japan Research Collaboration Center on Emerging and Re-emerging Infections (RCC-ERI) was established in 2005 as a research collaboration center cooperated by Research Institute for Microbial Diseases (RIMD), Osaka University and Department of Medical Sciences, Ministry of Public Health of Thailand. In addition, Mahidol-Osaka Center for Infectious Diseases (MOCID) was established in 2010, also as another research collaboration center cooperated by RIMD, Osaka University and Faculty of Tropical Medicine, Mahidol University...
2013: Uirusu
Mahdi Ramezani, Purang Abolmaesumi, Kris Marble, Heather Trang, Ingrid Johnsrude
Classification of individuals based on patterns of brain activity observed in functional MRI contrasts may be helpful for diagnosis of neurological disorders. Prior work for classification based on these patterns have primarily focused on using a single contrast, which does not take advantage of complementary information that may be available in multiple contrasts. Where multiple contrasts are used, the objective has been only to identify the joint, distinct brain activity patterns that differ between groups of subjects; not to use the information to classify individuals...
June 2015: Brain Imaging and Behavior
Hajime Sunakawa
The Faculty of Medicine, University of the Ryukyus, started a "Public Health Project in Lao P.D.R.", which is one of the JICA projects, in 1992, and has been carrying out the "Sethathirath Hospital Improvement Project" since 1999 to improve medical treatment and health care in Lao P.D.R. Marked progress has been made. In addition, the projects of "Medical support for cleft lip and palate patients" performed by both the Oral and Maxillofacial Surgery Department of the University of the Ryukyus Hospital and Okinawa-Laos Cleft Lip and Palate Support Center have continued since 2001...
September 2013: Rinsho Byori. the Japanese Journal of Clinical Pathology
Maria Rosario Z Capeding, Corina Jica, Anna Macura-Biegun, Martina Rauscher, Edison Alberto
Combination vaccines against diphtheria, tetanus and pertussis (DTP) represent the core of childhood vaccination programs. Quinvaxem, a fully-liquid, pentavalent combination vaccine containing inactivated hepatitis B (HepB), Haemophilus influenzae type b (Hib) and whole-cell pertussis (wP) antigens, and tetanus and diphtheria toxoids, has been shown to be suitable for boosting children primed in infancy with another DTwP-HepB-Hib vaccine. This single-blind, randomized, controlled study was designed to demonstrate non-inferiority of a primary vaccination course (6-10-14 week schedule) of Tritanrix HB+Hib (first dose) and Quinvaxem (second/third doses) versus three doses of Quinvaxem with respect to the seroprotection/seroconversion rates for all antigens one month after vaccination course completion...
February 7, 2014: Vaccine
Xun Chen, Z Jane Wang, Martin J McKeown
Corticomuscular coupling analysis based on multiple datasets such as electroencephalography (EEG) and electromyography (EMG) signals provides a useful tool for understanding human motor control systems. A popular conventional method to assess corticomuscular coupling has been the pair-wise magnitude-squared coherence (MSC) between EEG and concomitant EMG recordings. However, there are certain limitations associated with the MSC, including the difficulty in robustly assessing group inference, only dealing with two types of datasets simultaneously and the biologically implausible assumption of pair-wise interactions...
July 2014: IEEE Journal of Biomedical and Health Informatics
Motoyuki Yuasa, Yoshie Yamaguchi, Mihoko Imada
BACKGROUND: The Japan International Cooperation Agency (JICA) has focused its attention on appraising health development assistance projects and redirecting efforts towards health system strengthening. This study aimed to describe the type of project and targets of interest, and assess the contribution of JICA health-related projects to strengthening health systems worldwide. METHODS: We collected a web-based Project Design Matrix (PDM) of 105 JICA projects implemented between January 2005 and December 2009...
2013: BMC International Health and Human Rights
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