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https://www.readbyqxmd.com/read/28205018/the-donor-advocacy-team-a-risk-management-program-for-living-organ-tissue-and-cell-transplant-donors
#1
Susumu Eguchi, Akihiko Soyama, Kazuhiro Nagai, Yasushi Miyazaki, Shintaro Kurihara, Masaaki Hidaka, Shinichiro Ono, Tomohiko Adachi, Koji Natsuda, Takanobu Hara, Fumihiko Fujita, Kengo Kanetaka, Mistuhisa Takatsuki
BACKGROUND AND PURPOSE: Although the incidence of living donor death is low in Japan, statistics show one living liver donor death in more than 7000 living liver transplants. Thus, medical transplant personnel must recognize that the death of a living organ or tissue transplant donor can occur and develop an appropriate risk management program. METHODS AND RESULTS: We describe how Nagasaki University Hospital established and implemented a Donor Advocacy Team (DAT) program: a risk management program for initiation in the event of serious, persistent, or fatal impairment of an organ, tissue, or cell transplantation from a living donor...
February 15, 2017: Surgery Today
https://www.readbyqxmd.com/read/28188481/internal-exposure-to-neutron-activated-56-mn-dioxide-powder-in-wistar-rats-part%C3%A2-1-dosimetry
#2
Valeriy Stepanenko, Tolebay Rakhypbekov, Keiko Otani, Satoru Endo, Kenichi Satoh, Noriyuki Kawano, Kazuko Shichijo, Masahiro Nakashima, Toshihiro Takatsuji, Aya Sakaguchi, Hiroaki Kato, Yuichi Onda, Nariaki Fujimoto, Shin Toyoda, Hitoshi Sato, Altay Dyussupov, Nailya Chaizhunusova, Nurlan Sayakenov, Darkhan Uzbekov, Aisulu Saimova, Dariya Shabdarbaeva, Mazhin Skakov, Alexandr Vurim, Vyacheslav Gnyrya, Almas Azimkhanov, Alexander Kolbayenkov, Kasym Zhumadilov, Yankar Kairikhanova, Andrey Kaprin, Vsevolod Galkin, Sergey Ivanov, Timofey Kolyzhenkov, Aleksey Petukhov, Elena Yaskova, Irina Belukha, Artem Khailov, Valeriy Skvortsov, Alexander Ivannikov, Umukusum Akhmedova, Viktoria Bogacheva, Masaharu Hoshi
There were two sources of ionizing irradiation after the atomic bombings of Hiroshima and Nagasaki: (1) initial gamma-neutron irradiation at the moment of detonation and (2) residual radioactivity. Residual radioactivity consisted of two components: radioactive fallout containing fission products, including radioactive fissile materials from nuclear device, and neutron-activated radioisotopes from materials on the ground. The dosimetry systems DS86 and DS02 were mainly devoted to the assessment of initial radiation exposure to neutrons and gamma rays, while only brief considerations were given for the estimation of doses caused by residual radiation exposure...
February 10, 2017: Radiation and Environmental Biophysics
https://www.readbyqxmd.com/read/28186843/risks-and-cough-aggravating-factors-in-prolonged-cough-epidemiological-observations-from-the-nagahama-cohort-study
#3
Hisako Matsumoto, Yumi Izuhara, Akio Niimi, Yasuharu Tabara, Tadao Nagasaki, Yoshihiro Kanemitsu, Kimihiko Murase, Tsuyoshi Oguma, Isao Ito, Shigeo Muro, Akihiro Sekine, Fumihiko Matsuda, Shinji Kosugi, Takeo Nakayama, Kazuo Chin, Michiaki Mishima
RATIONALE: Chronic cough hypersensitivity, a potentially important concept of chronic or prolonged cough, is featured by heightened cough response to low-intensity stimuli, which may be generated in the absence of airflow limitations or allergic conditions. However, there is little epidemiological evidence to support this. OBJECTIVES: In this large-scale community survey, we aimed to determine risks and cough-aggravating factors of prolonged cough, while focusing on serum IgE levels...
February 10, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28180988/internal-exposure-to-neutron-activated-56-mn-dioxide-powder-in-wistar-rats-part%C3%A2-2-pathological-effects
#4
Kazuko Shichijo, Nariaki Fujimoto, Darkhan Uzbekov, Ynkar Kairkhanova, Aisulu Saimova, Nailya Chaizhunusova, Nurlan Sayakenov, Dariya Shabdarbaeva, Nurlan Aukenov, Almas Azimkhanov, Alexander Kolbayenkov, Zhanna Mussazhanova, Daisuke Niino, Masahiro Nakashima, Kassym Zhumadilov, Valeriy Stepanenko, Masao Tomonaga, Tolebay Rakhypbekov, Masaharu Hoshi
To fully understand the radiation effects of the atomic bombing of Hiroshima and Nagasaki among the survivors, radiation from neutron-induced radioisotopes in soil and other materials should be considered in addition to the initial radiation directly received from the bombs. This might be important for evaluating the radiation risks to the people who moved to these cities soon after the detonations and probably inhaled activated radioactive "dust." Manganese-56 is known to be one of the dominant radioisotopes produced in soil by neutrons...
February 8, 2017: Radiation and Environmental Biophysics
https://www.readbyqxmd.com/read/28177990/short-and-long-term-outcomes-of-laparoscopic-total-mesenteric-excision-for-neuroendocrine-tumors-of-the-rectum
#5
Yukiko Takatsu, Yosuke Fukunaga, Toshiya Nagasaki, Takashi Akiyoshi, Tsuyoshi Konishi, Yoshiya Fujimoto, Satoshi Nagayama, Masashi Ueno
BACKGROUND: To our knowledge, no studies to date have assessed the short- and long-term outcomes of laparoscopic total mesenteric excision in patients with neuroendocrine tumors of the rectum. OBJECTIVE: The purpose of this study was to investigate the short- and long-term outcomes of patients who underwent laparoscopic rectal resection plus total mesenteric excision for rectal neuroendocrine tumors at our institution. DESIGN: This was a single center, retrospective study...
March 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/28177008/formation-of-%C3%AE-1-3-1-6-d-glucan-complexed-70-fullerene-and-its-photodynamic-activity-towards-macrophages
#6
Atsushi Ikeda, Motofusa Akiyama, Kouta Sugikawa, Kazuya Koumoto, Yuta Kashijima, Jiawei Li, Toshio Suzuki, Takeshi Nagasaki
[70]Fullerene was dissolved in water by complexation with β-1,3-glucan using a mechanochemical high-speed vibration milling apparatus. The photodynamic activity of β-1,3-glucan-complexed C70 was highly dependent on the expression level of dectin-1 on the cell surfaces of macrophages. The photodynamic activity increased as a result of a synergistic effect between β-1,3-glucan-complexed 1'-acetoxychavicol acetate and the C70 complex.
February 8, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28163062/genome-wide-association-study-identifies-tll1-variant-associated-with-development-of-hepatocellular-carcinoma-after-eradication-of-hepatitis-c-virus-infection
#7
Kentaro Matsuura, Hiromi Sawai, Kazuho Ikeo, Shintaro Ogawa, Etsuko Iio, Masanori Isogawa, Noritomo Shimada, Atsumasa Komori, Hidenori Toyoda, Takashi Kumada, Tadashi Namisaki, Hitoshi Yoshiji, Naoya Sakamoto, Mina Nakagawa, Yasuhiro Asahina, Masayuki Kurosaki, Namiki Izumi, Nobuyuki Enomoto, Atsunori Kusakabe, Eiji Kajiwara, Yoshito Itoh, Tatsuya Ide, Akihiro Tamori, Misako Matsubara, Norifumi Kawada, Ken Shirabe, Eiichi Tomita, Masao Honda, Shuichi Kaneko, Sohji Nishina, Atsushi Suetsugu, Yoichi Hiasa, Hisayoshi Watanabe, Takuya Genda, Isao Sakaida, Shuhei Nishiguchi, Koichi Takaguchi, Eiji Tanaka, Junichi Sugihara, Mitsuo Shimada, Yasuteru Kondo, Yusuke Kawai, Kaname Kojima, Masao Nagasaki, Katsushi Tokunaga, Yasuhito Tanaka
BACKGROUND & AIMS: There is still a risk for hepatocellular carcinoma (HCC) development after eradication of hepatitis C virus (HCV) infection with anti-viral agents. We investigated genetic factors associated with the development of HCC in patients with a sustained virologic response (SVR) to treatment for chronic HCV infection. METHODS: We obtained genomic DNA from 457 patients in Japan with a SVR to interferon-based treatment for chronic HCV infection from 2007 through 2015...
February 2, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28132586/development-of-gd3n-c80-encapsulated-redox-nanoparticles-for-high-performance-magnetic-resonance-imaging
#8
Zhenyu Gao, Yusuke Nakanishi, Shoko Noda, Haruka Omachi, Hisanori Shinohara, Hiroyuki Kimura, Yukio Nagasaki
As novel magnetic resonance imaging (MRI) contrast agent, gadofullerene encapsulated redox nanoparticles (Gd3NPs) were prepared by encapsulation of Gd3N@C80 in the core of core-shell-type polymer micelles composed of original polyamine with a reactive oxygen species (ROS)-scavenging ability. Because Gd3NPs possess biocompatible PEG shell with a smaller size (ca. 50 nm), they had high colloidal stability in a physiological environment, and showed low cytotoxicity. Specific accumulation of Gd3NPs in a tumor was confirmed in tumor-bearing mice after systemic administration...
January 28, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28126327/serotype-specific-effectiveness-of-23-valent-pneumococcal-polysaccharide-vaccine-against-pneumococcal-pneumonia-in-adults-aged-65-years-or-older-a-multicentre-prospective-test-negative-design-study
#9
Motoi Suzuki, Bhim Gopal Dhoubhadel, Tomoko Ishifuji, Michio Yasunami, Makito Yaegashi, Norichika Asoh, Masayuki Ishida, Sugihiro Hamaguchi, Masahiro Aoshima, Koya Ariyoshi, Konosuke Morimoto
BACKGROUND: The serotype-specific effectiveness of 23-valent pneumococcal polysaccharide vaccine (PPV23) against pneumococcal pneumonia has not been established in people aged 65 years or older. We assessed the effectiveness of PPV23 in this population. METHODS: For this multicentre, prospective study, we enrolled all individuals aged 65 years or older with community-onset pneumonia who visited four study hospitals in Japan between Sept 28, 2011, and Aug 23, 2014...
January 23, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28117631/intracellular-position-of-centrioles-and-the-direction-of-homeostatic-epithelial-cell-movements-in-the-mouse-cornea
#10
Erika Silverman, Jin Zhao, John C Merriam, Takayuki Nagasaki
Corneal epithelial cells exhibit continuous centripetal movements at a rate of about 30 µm per day, but neither the driving force nor the mechanism that determines the direction of movements is known. To facilitate the investigation of homeostatic cell movement, we examined if the intracellular position of a centriole can be used as a directional marker of epithelial cell movements in the mouse cornea. A direction of cell movements was estimated in fixed specimens from a pattern of underlying subepithelial nerve fibers...
February 2017: Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society
https://www.readbyqxmd.com/read/28113419/fabrication-of-tetragonal-pb-zr-ti-o3-nanorods-by-focused-ion-beam-and-characterization-of-the-domain-structure
#11
Daisuke Ito, Tomoaki Yamada, Osami Sakata, Junki Kuroishi, Takahiro Namazu, Horoshi Funakubo, Masahito Yoshino, Takanori Nagasaki
It has been widely revealed and discussed that the properties of ferroelectric nanostructures vary with their dimensionality and size. The mechanical substrate clamping and the depolarization field are considered as major factors, which cause their unique properties. In this paper, we fabricated tetragonal {100}-Pb(Zr, Ti)O3 rods with 100 nm - 4 μm widths on Nb-doped SrTiO3 substrates by using focused ion beam, and characterized their domain structure by synchrotron micro X-ray diffraction. It was found that the clapping angle in the a/c-domain structure became larger with decreasing the rod width, which indicates the significant reduction of substrate clamping by fabricating narrow rods...
May 19, 2016: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28101345/%C3%AE-cell-function-prior-to-liver-transplantation-contributes-to-post-operative-diabetes
#12
Tatsuki Ichikawa, Naota Taura, Hisamitsu Miyaaki, Satoshi Miuma, Hidetaka Shibata, Takuya Honda, Masaaki Hidaka, Akihiko Soyama, Mitsuhisa Takatsuki, Susumu Eguchi, Kazuhiko Nakao
Liver cirrhosis and diabetes mellitus (DM) are closely associated. The present study aimed to determine whether liver transplantation (LT) may prevent/cure DM in patients with cirrhosis and whether the degree of glucose tolerance prior to transplantation is associated with the onset of DM after transplantation. Seventy-three patients who received a living donor LT at Nagasaki University Hospital (Nagasaki, Japan) between November 2005 and December 2012 were recruited. Among them, patients were considered diabetic if they had been prescribed diabetes medications or had impaired glucose tolerance, as evidenced by an oral glucose tolerance test (OGTT)...
December 2016: Biomedical Reports
https://www.readbyqxmd.com/read/28100913/genome-wide-association-study-using-the-ethnicity-specific-japonica-array-identification-of-new-susceptibility-loci-for-cold-medicine-related-stevens-johnson-syndrome-with-severe-ocular-complications
#13
Mayumi Ueta, Hiromi Sawai, Ryosei Shingaki, Yusuke Kawai, Chie Sotozono, Kaname Kojima, Kyung-Chul Yoon, Mee Kum Kim, Kyoung Yul Seo, Choun-Ki Joo, Masao Nagasaki, Shigeru Kinoshita, Katsushi Tokunaga
A genome-wide association study (GWAS) for cold medicine-related Stevens-Johnson syndrome (CM-SJS) with severe ocular complications (SOC) was performed in a Japanese population. A recently developed ethnicity-specific array with genome-wide imputation that was based on the whole-genome sequences of 1070 unrelated Japanese individuals was used. Validation analysis with additional samples from Japanese individuals and replication analysis using samples from Korean individuals identified two new susceptibility loci on chromosomes 15 and 16...
January 19, 2017: Journal of Human Genetics
https://www.readbyqxmd.com/read/28062665/genome-wide-association-studies-identify-prkcb-as-a-novel-genetic-susceptibility-locus-for-primary-biliary-cholangitis-in-the-japanese-population
#14
Minae Kawashima, Yuki Hitomi, Yoshihiro Aiba, Nao Nishida, Kaname Kojima, Yosuke Kawai, Hitomi Nakamura, Atsushi Tanaka, Mikio Zeniya, Etsuko Hashimoto, Hiromasa Ohira, Kazuhide Yamamoto, Masanori Abe, Kazuhiko Nakao, Satoshi Yamagiwa, Shuichi Kaneko, Masao Honda, Takeji Umemura, Takafumi Ichida, Masataka Seike, Shotaro Sakisaka, Masaru Harada, Osamu Yokosuka, Yoshiyuki Ueno, Michio Senju, Tatsuo Kanda, Hidetaka Shibata, Takashi Himoto, Kazumoto Murata, Yasuhiro Miyake, Hirotoshi Ebinuma, Makiko Taniai, Satoru Joshita, Toshiki Nikami, Hajime Ota, Hiroshi Kouno, Hirotaka Kouno, Makoto Nakamuta, Nobuyoshi Fukushima, Motoyuki Kohjima, Tatsuji Komatsu, Toshiki Komeda, Yukio Ohara, Toyokichi Muro, Tsutomu Yamashita, Kaname Yoshizawa, Yoko Nakamura, Masaaki Shimada, Noboru Hirashima, Kazuhiro Sugi, Keisuke Ario, Eiichi Takesaki, Atsushi Naganuma, Hiroshi Mano, Haruhiro Yamashita, Kouki Matsushita, Kazuhiko Yamauchi, Fujio Makita, Hideo Nishimura, Kiyoshi Furuta, Naohiro Takahashi, Masahiro Kikuchi, Naohiko Masaki, Tomohiro Tanaka, Sumito Tamura, Akira Mori, Shintaro Yagi, Ken Shirabe, Atsumasa Komori, Kiyoshi Migita, Masahiro Ito, Shinya Nagaoka, Seigo Abiru, Hiroshi Yatsuhashi, Michio Yasunami, Shinji Shimoda, Kenichi Harada, Hiroto Egawa, Yoshihiko Maehara, Shinji Uemoto, Norihiro Kokudo, Hajime Takikawa, Hiromi Ishibashi, Kazuaki Chayama, Masashi Mizokami, Masao Nagasaki, Katsushi Tokunaga, Minoru Nakamura
A previous genome-wide association study (GWAS) performed in 963 Japanese individuals (487 primary biliary cholangitis [PBC] cases and 476 healthy controls) identified TNFSF15 (rs4979462) and POU2AF1 (rs4938534) as strong susceptibility loci for PBC. In this study, we performed GWAS in an additional 1,923 Japanese individuals (894 PBC cases and 1,029 healthy controls), and combined the results with the previous data. This GWAS, together with a subsequent replication study in an independent set of 7,024 Japanese individuals (512 PBC cases and 6,512 healthy controls), identified PRKCB (rs7404928) as a novel susceptibility locus for PBC (odds ratio [OR] = 1...
January 5, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28055099/evaluation-of-therapeutic-tissue-crosslinking-txl-for-myopia-using-second-harmonic-generation-signal-microscopy-in-rabbit-sclera
#15
Mariya Zyablitskaya, Anna Takaoka, Emilia L Munteanu, Takayuki Nagasaki, Stephen L Trokel, David C Paik
Purpose: Second harmonic generation signals (SHG) are emitted preferentially from collagenous tissue structures and have been used to evaluate photochemically-induced (CXL) crosslinking changes in the cornea. Since therapeutic tissue crosslinking (TXL) using sodium hydroxymethylglycinate (SMG) of the sclera is a potential treatment for high myopia, we explored the use of SHG microscopy to evaluate the effects. Methods: Single sub-Tenon's (sT) injections (400 μL) using SMG (40-400 mM) were made at the equatorial 12 o'clock position of the right eye of cadaveric rabbit heads (n = 16 pairs)...
January 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28049988/effects-of-long-term-physical-training-on-the-bearers-of-a-float-during-the-nagasaki-kunchi-festival
#16
Shigemori Shibata, Hiroaki Kawano, Koji Maemura
Objective The Nagasaki Kunchi Festival is one of the most famous festivals in Nagasaki. The bearers the floats that are used in this festival undergo long-term training for the performance. However, there have not been any studies on the effects of this training on the health of the float bearers. Methods Thirty-four men ranging in age from 20 to 49 years (mean age: 35.77.6 years) were included in the study. We examined the following parameters before and after the training: body weight (BW), body mass index (BMI), body fat percentage, muscle volume, systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse rate (PR), pulse pressure (PP), bearing power, arterial pressure volume index (API), and arterial velocity pulse index (AVI)...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28035549/prevalence-of-restless-legs-syndrome-in-patients-with-inflammatory-bowel-disease
#17
Ikuko Takahara, Fuminao Takeshima, Tatsuki Ichikawa, Toshihisa Matsuzaki, Hidetaka Shibata, Satoshi Miuma, Yuko Akazawa, Hisamitsu Miyaaki, Naota Taura, Kazuhiko Nakao
BACKGROUND AND AIM: There has been increased interest in sleep disorders in patients with inflammatory bowel disease (IBD). Studies in North America and Europe reported that the prevalence of restless legs syndrome (RLS) is much higher in patients with Crohn's disease (CD) than in the general population. The aim of this study was to reveal the prevalence and clinical features of RLS in Japanese patients with IBD and investigate the influence of RLS on sleep quality and quality of life (QOL)...
December 29, 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28034578/staphylococcus-aureus-enterotoxin-sensitization-involvement-and-its-association-with-the-cysltr1-variant-in-different-asthma-phenotypes
#18
Hisako Matsumoto, Yoshihiro Kanemitsu, Tadao Nagasaki, Yuji Tohda, Takahiko Horiguchi, Hideo Kita, Kazunobu Kuwabara, Keisuke Tomii, Kojiro Otsuka, Masaki Fujimura, Noriyuki Ohkura, Katsuyuki Tomita, Akihito Yokoyama, Hiroshi Ohnishi, Yasutaka Nakano, Tetsuya Oguma, Soichiro Hozawa, Yumi Izuhara, Isao Ito, Tsuyoshi Oguma, Hideki Inoue, Tomoko Tajiri, Toshiyuki Iwata, Junya Ono, Shoichiro Ohta, Tomomitsu Hirota, Takahisa Kawaguchi, Mayumi Tamari, Tetsuji Yokoyama, Yasuharu Tabara, Fumihiko Matsuda, Kenji Izuhara, Akio Niimi, Michiaki Mishima
BACKGROUND: Sensitization to Staphylococcus aureus enterotoxin (SE) is a known risk factor for asthma susceptibility and severity. However, how SE sensitization is involved in asthma, particularly nonatopic asthma and/or late-onset asthma, remains uncertain. OBJECTIVE: To clarify the involvement of SE sensitization in nonatopic and/or late-onset asthma and its association with a polymorphism of the cysteinyl leukotriene receptor 1 gene (CysLTR1), which was examined because CysLT signaling is closely associated with late-onset eosinophilic asthma...
December 26, 2016: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28027541/initial-healthcare-to-pediatric-population-under-the-radiation-events
#19
D E Afanasyev, O V Kaminskyi, O V Kopylova, I G Chikalova, I M Muraveva, K O Vakoluk, O V Pronin, O O Samoylov, T O Belingio, O V Tepla, L V Rozhkivska, I V Ylyanchenko, K V Gryschenko, L O Tsvet, N S Dombrovska
The objective of this paper is to analyze the data from scientific literature and available recommendations for health professionals on healthcare providing to pediatric population in the events associated with risk of radiation exposure. Over the past sixty years there were several large scale radiological events with a large number of chil dren affected, namely the atomic bombing of Hiroshima and Nagasaki, accident at the Chornobyl nuclear power plant, contact to 137Cs radiation source unutilized at the hospital shutdown in Brazil etc...
December 2016: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
https://www.readbyqxmd.com/read/28025246/mosquito-species-diptera-culicidae-persistence-and-synchrony-across-an-urban-altitudinal-gradient
#20
Luis Fernando Chaves
Patterns of mosquito spatial persistence and temporal presence, as well as synchrony, i.e., the degree of concerted fluctuations in abundance, have been scarcely studied at finely grained spatial scales and over altitudinal gradients. Here, we present a spatial persistence, temporal presence, and synchrony analysis of four common mosquito species across the altitudinal gradient of Mt. Konpira in Nagasaki, Japan. We found that Aedes albopictus (Skuse) was more frequently found at the mountain base. In contrast, Aedes japonicus (Theobald) and Aedes flavopictus Yamada were common higher in the mountain, while Armigeres subalbatus (Coquillet) was uniformly present across the mountain, yet less frequently than the other species during the studied period...
December 26, 2016: Journal of Medical Entomology
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