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https://www.readbyqxmd.com/read/29774666/-engagement-ring-image-conveys-regrettable-outcome-for-aged-patients-with-non-small-cell-lung-cancer
#1
Hiromichi Yamane, Hiroyuki Nishie, Nobuaki Ochi, Tomoko Yamagishi, Nozomu Nakagawa, Yasunari Nagasaki, Hidekazu Nakanishi, Nagio Takigawa
No abstract text is available yet for this article.
May 17, 2018: Thoracic Cancer
https://www.readbyqxmd.com/read/29769267/functional-characterization-of-21-allelic-variants-of-dihydropyrimidine-dehydrogenase-identified-in-1-070-japanese-individuals
#2
Eiji Hishinuma, Yoko Narita, Sakae Saito, Masamitsu Maekawa, Fumika Akai, Yuya Nakanishi, Jun Yasuda, Masao Nagasaki, Masayuki Yamamoto, Hiroaki Yamaguchi, Nariyasu Mano, Noriyasu Hirasawa, Masahiro Hiratsuka
Dihydropyrimidine dehydrogenase (DPD, EC 1.3.1.2), encoded by the DPYD gene, is the rate-limiting enzyme in the degradation pathway of endogenous pyrimidine and fluoropyrimidine drugs such as 5-fluorouracil (5-FU). DPD catalyzes the reduction of uracil, thymine, and 5-FU. In Caucasians, DPYD mutations, including DPYD*2A, DPYD*13, c.2846A>T, and 1129-5923C>G/hapB3, are known to contribute to interindividual variations in the toxicity of 5-FU. However, none of these DPYD polymorphisms have been identified in the Asian population...
May 16, 2018: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/29765177/new-estimation-model-of-the-initial-lower-limb-angle-to-improve-angle-estimation-during-the-extension-phase-of-standing-up-movement
#3
Fang Jin, Takayuki Nagasaki, Chikamune Wada
[Purpose] An estimation model of the knee and ankle joint angles during the extension phase was proposed in the previous study. However, it had limited use because of the fixed initial lower limb angle before standing up. This study aimed to propose a new estimation model of the initial lower limb angle to improve the angle estimation during extension phase. [Subjects and Methods] Seven healthy male volunteers were enrolled. The new estimation model approximated the initial lower limb angle using a force sensor plate that measured the plantar pressure of the subjects...
May 2018: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29760319/hepatic-eosinophilic-abscess-associated-with-sigmoid-colon-cancer
#4
Yasuyuki Shigematsu, Hiroaki Kanda, Toshiya Nagasaki, Takeaki Ishizawa, Yosuke Inoue, Shunji Takahashi
The clinical course of hepatic eosinophilic abscess (HEA) induced by malignant tumors is not well-known; however, it is considered to be a benign hepatic lesion. HEA is difficult to diagnose by imaging alone and a pathological examination is generally needed, particularly in patients with malignant tumors, because the radiological findings can be similar to those of metastasis. We report a case of multiple HEAs with eosinophilia and sigmoid colon cancer that was difficult to diagnose without a pathological examination...
2018: Internal Medicine
https://www.readbyqxmd.com/read/29750423/nrp1-knockdown-promotes-the-migration-and-invasion-of-human-neuroblastoma-derived-sk%C3%A2-n%C3%A2-as-cells-via-the-activation-of-%C3%AE-1-integrin-expression
#5
Yoshiaki Ishizuka, Tsugumichi Koshinaga, Takayuki Hirano, Eri Nagasaki-Maeoka, Yosuke Watanabe, Reina Hoshi, Shinsuke Yoshizawa, Kiminobu Sugito, Hiroyuki Kawashima, Shota Uekusa, Noboru Fukuda, Masayoshi Soma, Kyoko Fujiwara
Neuropilin 1 (NRP1) is a transmembrane glycoprotein, which regulates many aspects of cellular function by functioning as co-receptor of various ligands. Recent studies have suggested that NRP1 promotes tumorigenesis, not only by activating the growth of tumor vessels, but also by activating the growth or migration of tumor cells themselves. The present study was performed to elucidate the roles of NRP1 in the development and/or progression of neuroblastoma (NB). In contrast to previous observations in various types of cancer, the analysis of public datasets indicated that lower levels of NRP1 expression were significantly associated with a shorter survival period of patients with NB...
May 7, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29709981/plasmid-mediated-ampc-%C3%AE-lactamase-and-underestimation-of-extended-spectrum-%C3%AE-lactamase-in-cefepime-susceptible-elevated-ceftazidime-mic-enterobacteriaceae-isolates
#6
Fumitaka Nishimura, Yoshitomo Morinaga, Norihiko Akamatsu, Junichi Matsuda, Norihito Kaku, Kazuaki Takeda, Naoki Uno, Kosuke Kosai, Hiroo Hasegawa, Katsunori Yanagihara
Phenotypic detection of extended-spectrum β-lactamase (ESBL) is important for public health and infection control; however, plasmid-mediated AmpC β-lactamases (pAmpCs) can interfere with the ESBL-phenotyping. We focused on Enterobacteriaceae strains which were susceptible to cefepime but had mildly-elevated MIC of ceftazidime, and studied the impact of pAmpC on the ESBL-phenotyping in this population. Genotyping of ESBL and pAmpC were performed on 528 clinical isolates of Escherichia coli, Klebsiella spp...
April 27, 2018: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29705864/protection-of-coral-larvae-from-thermally-induced-oxidative-stress-by-redox-nanoparticles
#7
Keisuke Motone, Toshiyuki Takagi, Shunsuke Aburaya, Wataru Aoki, Natsuko Miura, Hiroyoshi Minakuchi, Haruko Takeyama, Yukio Nagasaki, Chuya Shinzato, Mitsuyoshi Ueda
Coral reefs are one of the most biologically diverse and economically important ecosystems on earth. However, the destruction of coral reefs has been reported worldwide owing to rising seawater temperature associated with global warming. In this study, we investigated the potential of a redox nanoparticle (RNPO ) to scavenge reactive oxygen species (ROS), which are overproduced under heat stress and play a crucial role in causing coral mortality. When reef-building coral (Acropora tenuis) larvae, without algal symbionts, were exposed to thermal stress at 33 °C, RNPO treatment significantly increased the survival rate...
April 28, 2018: Marine Biotechnology
https://www.readbyqxmd.com/read/29701317/omics-research-project-on-prospective-cohort-studies-from-the-tohoku-medical-megabank-project
#8
REVIEW
Seizo Koshiba, Ikuko Motoike, Daisuke Saigusa, Jin Inoue, Matsuyuki Shirota, Yasutake Katoh, Fumiki Katsuoka, Inaho Danjoh, Atsushi Hozawa, Shinichi Kuriyama, Naoko Minegishi, Masao Nagasaki, Takako Takai-Igarashi, Soichi Ogishima, Nobuo Fuse, Shigeo Kure, Gen Tamiya, Osamu Tanabe, Jun Yasuda, Kengo Kinoshita, Masayuki Yamamoto
Population-based prospective cohort studies are indispensable for modern medical research as they provide important knowledge on the influences of many kinds of genetic and environmental factors on the cause of disease. Although traditional cohort studies are mainly conducted using questionnaires and physical examinations, modern cohort studies incorporate omics and genomic approaches to obtain comprehensive physical information, including genetic information. Here, we report the design and midterm results of multi-omics analysis on population-based prospective cohort studies from the Tohoku Medical Megabank (TMM) Project...
April 27, 2018: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
https://www.readbyqxmd.com/read/29695572/the-feasibility-and-efficacy-of-laparoscopic-extended-total-mesorectal-excision-for-locally-advanced-lower-rectal-cancer
#9
Takashi Nonaka, Akiko Fukuda, Kyoichiro Maekawa, Shigeki Nagayoshi, Takayuki Tokunaga, Mitsutoshi Takatsuki, Tomoo Kitajima, Ken Taniguchi, Hikaru Fujioka
BACKGROUND/AIM: Extended total mesorectal excision (ETME) is defined as en bloc resection of the adjacent organs outside the mesorectal fascia, that is indicated in cases with locally advanced lower rectal cancer (T4 tumor). The aim of this study was to evaluate the clinical and oncological outcomes of laparoscopic ETME (L-ETME) for locally advanced lower rectal cancer. PATIENTS AND METHODS: The present study analyzed clinical outcomes and oncological outcomes of 11 consecutive patients who underwent L-ETME for cT4 lower rectal cancer in Nagasaki Medical Center between 2012 and 2015...
May 2018: In Vivo
https://www.readbyqxmd.com/read/29684078/ovarian-mast-cells-migrate-toward-ovary-fimbria-connection-in-neonatal-mrl-mpj-mice
#10
Teppei Nakamura, Masataka Chihara, Osamu Ichii, Saori Otsuka-Kanazawa, Ken-Ichi Nagasaki, Yaser Hosny Ali Elewa, Osamu Tatsumi, Yasuhiro Kon
MRL/MpJ mice have abundant ovarian mast cells (MCs) as compared with other strains at postnatal day 0 (P0); however, they sharply decrease after birth. These ovarian MCs, particularly beneath the ovarian surface epithelium (SE), which express mucosal MC (MMC) marker, might participate in early follicular development. This study investigated the changes in spatiotemporal distribution of MCs in the perinatal MRL/MpJ mouse ovaries. At P0 to P7, the MCs were densely localized to the ovary, especially their caudomedial region around the ovary-fimbria connection...
2018: PloS One
https://www.readbyqxmd.com/read/29665435/neuraminidase-inhibitor-susceptibility-and-evolutionary-analysis-of-human-influenza-b-isolates-from-three-asian-countries-during-2012-2015
#11
Akinobu Hibino, Elie Massaad, Hiroki Kondo, Reiko Saito, Takashi Odagiri, Nobuhiro Takemae, Ryota Tsunekuni, Takehiko Saito, Yadanar Kyaw, Nay Lin, Yi Yi Myint, Htay Htay Tin, Nguyen Le Khanh Hang, Le Quynh Mai, Ren Yagami, Yugo Shobugawa, Tommy Lam, Hassan Zaraket
Influenza B viruses of both the Yamagata and the Victoria lineages are implicated in a large proportion of the morbidity and mortality associated with influenza outbreaks. In this study, we characterized the full genomes of 53 influenza B viruses isolated during 2012-2015 in three Asian countries: Japan, Myanmar, and Vietnam. Analysis of the hemagglutinin (HA) genes revealed co-circulation of both the Yamagata and Victoria lineages within the same season in these countries. Our analysis revealed, that a large proportion of viruses circulating during 2013-2014 in Japan and Vietnam were mismatched to the vaccine supporting the rationale for using quadrivalent vaccines...
April 14, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29665315/convergent-synthesis-of-a-bisecting-glcnac-containing-n-glycan
#12
Yoshiyuki Manabe, Hiroki Shomura, Naoya Minamoto, Masahiro Nagasaki, Yohei Takakura, Katsunori Tanaka, Alba Silipo, Antonio Molinaro, Koichi Fukase
The chemical synthesis of a bisecting N-acetylglucosamine (GlcNAc)-containing N-glycan was achieved by a convergent synthetic route via [4+2] and [6+2] glycosylations. This synthetic route reduced the number of reaction steps, although the key glycosylations were challenging in terms of yields and selectivities due to steric hindrance at the glycosylation site and a lack of neighboring group participation. The yields of these glycosylations were enhanced by stabilizing the oxocarbenium ion intermediate through ether coordination...
April 17, 2018: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/29659940/risk-factors-for-pericardial-effusion-after-chemoradiotherapy-for-thoracic-esophageal-cancer-comparison-of-four-field-technique-and-traditional-two-opposed-fields-technique
#13
Noriko Takata, Masaaki Kataoka, Yasushi Hamamoto, Shintaro Tsuruoka, Hiromitsu Kanzaki, Kotaro Uwatsu, Kei Nagasaki, Teruhito Mochizuki
Pericardial effusion is an important late toxicity after concurrent chemoradiotherapy (CCRT) for locally advanced esophageal cancer. We investigated the clinical and dosimetric factors that were related to pericardial effusion among patients with thoracic esophageal cancer who were treated with definitive CCRT using the two opposed fields technique (TFT) or the four-field technique (FFT), as well as the effectiveness of FFT. During 2007-2015, 169 patients with middle and/or lower thoracic esophageal cancer received definitive CCRT, and 94 patients were evaluable (51 FFT cases and 43 TFT cases)...
April 11, 2018: Journal of Radiation Research
https://www.readbyqxmd.com/read/29624907/laparoscopic-right-hemicolectomy-for-a-colon-cancer-patient-with-an-ileal-conduit
#14
Shinsuke Suzuki, Toshiya Nagasaki, Takashi Akiyoshi, Tsuyoshi Konishi, Yoshiya Fujimoto, Satoshi Nagayama, Yosuke Fukunaga, Hironori Fukuoka, Hajime Ushigome, Satoshi Murahashi, Shun Miyanari, Hironori Minami, Masashi Ueno
Here, we describe our experience of laparoscopic surgery in a colon cancer patient with an ileal conduit. To our knowledge, this is the second case presented in the English-language literature. A 71-year-old woman with a history of both open anterior exenteration with ileal conduit reconstruction for bladder cancer and open cholecystectomy for cholecystitis was diagnosed with ascending colon cancer (cT3N1M0). Laparoscopic right hemicolectomy with conduit preservation was planned. After adhesiolysis, complete mesocolic excision and central vascular ligation were achieved laparoscopically without injury to the conduit or other structures...
April 6, 2018: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/29617935/pre-bombing-population-density-in-hiroshima-and-nagasaki-its-measurement-and-impact-on-radiation-risk-estimates-in-the-life-span-study-of-atomic-bomb-survivors
#15
Benjamin French, Sachiyo Funamoto, Hiromi Sugiyama, Ritsu Sakata, John Cologne, Harry M Cullings, Kiyohiko Mabuchi, Dale L Preston
In the Life Span Study of atomic bomb survivors, differences in urbanicity between high-dose and low-dose survivors could confound the association between radiation dose and adverse outcomes. We obtained data on the pre-bombing population distribution in Hiroshima and Nagasaki, and quantified the impact of adjustment for population density on radiation risk estimates for mortality (1950-2003) and incident solid cancer (1958-2009). Population density ranged from 4,671-14,378 and 5,748-19,149 people/km2 in urban regions of Hiroshima and Nagasaki, respectively...
March 29, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29606119/invasive-meningococcal-disease-due-to-a-non-capsulated-neisseria-meningitidis-strain-in-a-patient-with-igg4-related-disease
#16
Shun Kurose, Kyoko Onozawa, Hiroshi Yoshikawa, Kenichiro Yaita, Hideyuki Takahashi, Nobuyuki Shimono, Yoji Nagasaki
BACKGROUND: Invasive Meningococcal Disease (IMD) is a rare and critical disease in Japan. Most of these cases are caused by capsulated Neisseria meningitidis strains. Non-capsulated (non-typable) strains are considered relatively low-pathogenic and can colonize in the nasopharynx of healthy children and young adults. As far as could be ascertained, only twelve IMD cases due to non-capsulated strains have been reported in the literature. No clear risk factors could be identified in a literature review (unknown or immunocompetent, seven cases; C6 deficiency, three cases)...
April 2, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29603369/clinical-and-genetic-risk-factors-for-decreased-bone-mineral-density-in-japanese-patients-with-inflammatory-bowel-disease
#17
Takeo Naito, Naonobu Yokoyama, Yoichi Kakuta, Kazuko Ueno, Yosuke Kawai, Motoyuki Onodera, Rintaro Moroi, Masatake Kuroha, Yoshitake Kanazawa, Tomoya Kimura, Hisashi Shiga, Katsuya Endo, Masao Nagasaki, Atsushi Masamune, Yoshitaka Kinouchi, Tooru Shimosegawa
BACKGROUND AND AIM: Patients with inflammatory bowel disease (IBD) are at a high risk of low bone mineral density (BMD). Reportedly, clinical and genetic factors cause low BMD in Caucasians; however, studies in non-Caucasian populations remain scarce. METHODS: Clinical risk factors for low BMD were investigated in 266 Japanese patients with IBD, and a genome-wide association analysis (GWAS) was performed using linear regression with associated clinical factors as covariates...
March 30, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29582539/association-between-atherosclerosis-and-handgrip-strength-in-non-hypertensive-populations-in-india-and-japan
#18
Hirotomo Yamanashi, Bharati Kulkarni, Tansy Edwards, Sanjay Kinra, Jun Koyamatsu, Mako Nagayoshi, Yuji Shimizu, Takahiro Maeda, Sharon E Cox
AIM: Although several risk factors contribute to the development of sarcopenia, whether preclinical atherosclerosis contributes to the risk of sarcopenia is not established. The present cross-sectional study aimed to investigate if there is an association between preclinical atherosclerosis and muscle strength among two ethnic populations. METHODS: Participants included individuals aged ≥40 years and enrolled in the third follow-up examination of the Andhra Pradesh Children and Parents Study, India, and in the baseline assessments of the Nagasaki Islands Study, Japan...
March 26, 2018: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/29572179/continuous-application-of-compressive-force-induces-fusion-of-osteoclast-like-raw264-7-cells-via-upregulation-of-rank-and-downregulation-of-lgr4
#19
Rieko Matsuike, Hideki Tanaka, Kumiko Nakai, Mai Kanda, Maki Nagasaki, Fumiko Murakami, Chika Shibata, Kotoe Mayahara, Akira Nakajima, Natsuko Tanabe, Takayuki Kawato, Masao Maeno, Noriyoshi Shimizu
AIMS: During orthodontic treatment, facilitating osteoclastic bone resorption in the alveolar bone exposed to the compressive force (CF) is an important factor for tooth movement. The present study investigated the effect of CF stimulation on the differentiation of RAW264.7 cells from precursors to mature osteoclasts. MAIN METHODS: The cells were continuously stimulated with 0.3, 0.6, or 1.1 g/cm2 CF-which was generated by increasing the volume of culture medium in the wells of a 96-well plate-in the presence or absence of receptor activator of nuclear factor κB (RANK) ligand (RANKL) for 4 days...
March 20, 2018: Life Sciences
https://www.readbyqxmd.com/read/29571050/novel-angiogenesis-therapeutics-by-redox-injectable-hydrogel-regulation-of-local-nitric-oxide-generation-for-effective-cardiovascular-therapy
#20
Long Binh Vong, Thang Quoc Bui, Tsutomu Tomita, Hiroaki Sakamoto, Yuji Hiramatsu, Yukio Nagasaki
Nitric oxide (NO) possesses various functions in cardiovascular diseases; however, due to an extremely short half-life and low bioavailability, its therapeutic application is limited. In inflamed tissues, overproduced reactive oxygen species (ROS) rapidly react with the endogenous NO, reducing its bioavailability. Here, we developed a controllable NO-releasing redox injectable hydrogel (NO-RIG) formed by the electrostatic crosslinking between the polyion complex flower-type micelles composing of functional polymers to scavenge overproduced ROS and regulate the local NO expression level simultaneously...
March 13, 2018: Biomaterials
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