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https://www.readbyqxmd.com/read/28915391/hepatitis-b-surface-antigen-incorporated-in-dissolvable-microneedle-array-patch-is-antigenic-and-thermostable
#1
Danielle Poirier, Frédéric Renaud, Vincent Dewar, Laurent Strodiot, Florence Wauters, Jim Janimak, Toshio Shimada, Tatsuya Nomura, Koki Kabata, Koji Kuruma, Takayuki Kusano, Masaki Sakai, Hideo Nagasaki, Takayoshi Oyamada
Alternatives to syringe-based administration are considered for vaccines. Intradermal vaccination with dissolvable microneedle arrays (MNA) appears promising in this respect, as an easy-to-use and painless method. In this work, we have developed an MNA patch (MNAP) made of hydroxyethyl starch (HES) and chondroitin sulphate (CS). In swines, hepatitis B surface antigen (HBsAg) formulated with the saponin QS-21 as adjuvant, both incorporated in HES-based MNAP, demonstrated the same level of immunogenicity as a commercially available aluminum-adjuvanted HBsAg vaccine, after two immunizations 28 days apart...
August 29, 2017: Biomaterials
https://www.readbyqxmd.com/read/28912738/prejudice-and-health-anxiety-about-radiation-exposure-from-second-generation-atomic-bomb-survivors-results-from-a-qualitative-interview-study
#2
Yuka Kamite
The effect of atomic bomb radiation exposure on the survivors and their children has been a worrisome problem since soon after the 1945 Hiroshima and Nagasaki bombings. Researchers have examined physical and genetic effects; however, no research has focused on second-generation survivors' (SGS) psychological effects. Consequently, this study shed light on the SGS' experience of discrimination and prejudice and their anxiety concerning the genetic effects of radiation exposure. This study utilized semi-structured interviews with 14 SGS (10 women, mean age = 56 ± 6...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28893357/fluoroquinolone-resistance-in-extended-spectrum-%C3%AE-lactamase-producing-klebsiella-pneumoniae-in-a-japanese-tertiary-hospital-silent-shifting-to-ctx-m-15-producing-k-pneumoniae
#3
Masashi Higashino, Mika Murata, Yoshitomo Morinaga, Norihiko Akamatsu, Junichi Matsuda, Kazuaki Takeda, Norihito Kaku, Kosuke Kosai, Naoki Uno, Hiroo Hasegawa, Katsunori Yanagihara
PURPOSE: Fluoroquinolone resistance (FQ-r) in extended-spectrum β-lactamase (ESBL) producers is an urgent health concern in countries where ESBL-producing K. pneumoniae (ESBL-Kpn) is prevalent. We investigated FQ-r in Japan where ESBL-Kpn is less prevalent. METHODOLOGY: Clinical ESBL-Kpn isolates from 2011 to 2013 were collected in Nagasaki University Hospital. The ESBL genotypes included CTX-M-15, and the mechanisms of FQ-r through plasmid-mediated quinolone resistance (PMQR) and mutations in quinolone resistance-determining regions (QRDRs) were examined...
September 12, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28867705/validating-the-effectiveness-of-switching-the-vancomycin-tdm-analysis-software-based-on-the-predictive-accuracy
#4
Shungo Imai, Takehiro Yamada, Nobuhisa Ishiguro, Takenori Miyamoto, Keisuke Kagami, Naoki Tomiyama, Yusuke Niinuma, Daisuke Nagasaki, Koji Suzuki, Akira Yamagami, Kumiko Kasashi, Masaki Kobayashi, Ken Iseki
 Based on the predictive performance in our previous study, we switched the therapeutic drug monitoring (TDM) analysis software for dose setting of vancomycin (VCM) from "Vancomycin MEEK TDM analysis software Ver2.0" (MEEK) to "SHIONOGI-VCM-TDM ver.2009" (VCM-TDM) in January 2015. In the present study, our aim was to validate the effectiveness of the changing VCM TDM analysis software in initial dose setting of VCM. The enrolled patients were divided into two groups, each having 162 patients in total, who received VCM with the initial dose set using MEEK (MEEK group) or VCM-TDM (VCM-TDM group)...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/28858867/pretreatment-serum-carbohydrate-antigen-19-9-concentration-is-a-predictor-of-survival-of-patients-who-have-undergone-curative-resection-of-stage-iv-rectal-cancer
#5
Hisanori Miki, Takashi Akiyoshi, Atsushi Ogura, Toshiya Nagasaki, Tsuyoshi Konishi, Yoshiya Fujimoto, Satoshi Nagayama, Hisashi Noma, Akio Saiura, Yosuke Fukunaga, Masashi Ueno
BACKGROUND: To evaluate whether pretreatment carcinoembryonic antigen and carbohydrate antigen (CA)19-9 are useful predictors of survival in patients with stage IV rectal cancer who have undergone curative resection. METHODS: In this retrospective study, data on 73 patients who had undergone curative resection of stage IV rectal cancer were reviewed. Associations between various clinicopathological factors and survival outcomes were analyzed. RESULTS: According to univariate analysis, elevated pretreatment CA19-9 (p = 0...
September 1, 2017: Digestive Surgery
https://www.readbyqxmd.com/read/28855440/the-position-of-the-gfp-tag-on-actin-affects-the-filament-formation-in-mammalian-cells
#6
Akira Nagasaki, Saku T Kijima, Tenji Yumoto, Miku Imaizumi, Ayana Yamagishi, Hyonchol Kim, Chikashi Nakamura, Taro Q P Uyeda
Actin, a major component of microfilaments, is involved in various eukaryotic cellular functions. Over the past two decades, actin fused with fluorescent protein has been used as a probe to detect the organization and dynamics of the actin cytoskeleton in living eukaryotic cells. It is generally assumed that the expression of fusion protein of fluorescent protein does not disturb the distribution of endogenous actin throughout the cell, and that the distribution of the fusion protein reflects that of endogenous actin...
2017: Cell Structure and Function
https://www.readbyqxmd.com/read/28846585/plutonium-bioassay-testing-of-united-states-atmospheric-nuclear-test-participants-and-occupation-forces-of-hiroshima-and-nagasaki-japan
#7
Dennis Michael Schaeffer, David R Case, Joanna T Ingraham, Paul K Blake
The pilot urine plutonium bioassay testing program engaged 100 atomic veterans and 58 persons representative of the United States general population using the fission track analysis technique, developed by Brookhaven National Laboratory. The methodology, collected data, scientific challenges, and test results are presented herein. The Defense Threat Reduction Agency and its predecessor agencies conducted this program in the late 1990s to the mid-2000s to determine the feasibility of bioassay testing to supplement dose reconstruction to estimate atomic veterans' doses under the agency's Nuclear Test Personnel Review Program...
October 2017: Health Physics
https://www.readbyqxmd.com/read/28845514/neoadjuvant-hormonal-therapy-for-low-risk-prostate-cancer-induces-biochemical-recurrence-after-radical-prostatectomy-via-increased-lymphangiogenesis-related-parameters
#8
Yasuyoshi Miyata, Yuichiro Nakamura, Takuji Yasuda, Tomohiro Matsuo, Kojiro Ohba, Bungo Furusato, Junya Fukuoka, Hideki Sakai
BACKGROUND: The effects of neoadjuvant hormonal therapy (NHT) on pathological features and lymphangiogenesis in patients with prostate cancer (PCa) for each pre-operative risk classification are unclear. METHODS: To clarify the anti-cancer effects of NHT, we investigated 153 patients (non-NHT group = 80 and NHT group = 73) who underwent radical prostatectomy (RP) in Nagasaki University Hospital. Lymph vessel density and area (evaluated by D2-40-positive vessels), vascular endothelial growth factor (VEGF)-C and VEGF-D expressions, and biochemical recurrence (BCR)-free survival were compared between these two groups for each D'Amico risk classification (low = 33, intermediate = 58, high = 62 patients)...
August 28, 2017: Prostate
https://www.readbyqxmd.com/read/28842649/structure-based-drug-discovery-for-combating-influenza-virus-by-targeting-the-pa-pb1-interaction
#9
Ken Watanabe, Takeshi Ishikawa, Hiroki Otaki, Satoshi Mizuta, Tsuyoshi Hamada, Takehiro Nakagaki, Daisuke Ishibashi, Shuzo Urata, Jiro Yasuda, Yoshimasa Tanaka, Noriyuki Nishida
Influenza virus infections are serious public health concerns throughout the world. The development of compounds with novel mechanisms of action is urgently required due to the emergence of viruses with resistance to the currently-approved anti-influenza viral drugs. We performed in silico screening using a structure-based drug discovery algorithm called Nagasaki University Docking Engine (NUDE), which is optimised for a GPU-based supercomputer (DEstination for Gpu Intensive MAchine; DEGIMA), by targeting influenza viral PA protein...
August 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28833559/chiroptical-properties-of-dithia-3-3-cyclophanes-composed-of-anthracene-and-pyridine-pyridinium-moieties-a-combined-experimental-and-theoretical-study
#10
Akinori Shimizu, Keisuke Nagasaki, Yoshihisa Inoue, Tadashi Mori
Circular dichroisms (CDs) of neutral and protonated [3.3]anthracenopyridinophane (1 and 1-H(+) ) were investigated experimentally and theoretically. Introducing an anthracene moiety with extended conjugation affected the cyclophane structure with the bent angles being appreciably  reduced from those of parent [3.3]pyridinophane. The Cotton effects (CEs) observed at the (1) Bb band for both 1 and 1-H(+) were fairly strong and apparently bisignate, which, however, turned out not to be a simple exciton couplet but to be composed of multiple transitions...
August 18, 2017: Chirality
https://www.readbyqxmd.com/read/28820355/alpha-particles-and-x-rays-interact-in-inducing-dna-damage-in-u2os-cells
#11
Alice Sollazzo, Beata Brzozowska, Lei Cheng, Lovisa Lundholm, Siamak Haghdoost, Harry Scherthan, Andrzej Wojcik
Survivors of the atomic bombings of Hiroshima and Nagasaki are monitored for health effects within the Life Span Study (LSS). The LSS results represent the most important source of data about cancer effects from ionizing radiation exposure, which forms the foundation for the radiation protection system. One uncertainty connected to deriving universal risk factors from these results is related to the problem of mixed radiation qualities. The A-bomb explosions generated a mixed beam of the sparsely ionizing gamma radiation and densely ionizing neutrons...
August 18, 2017: Radiation Research
https://www.readbyqxmd.com/read/28794378/emphysematous-cystitis
#12
Kazuya Nagasaki, Harumi Gomi
No abstract text is available yet for this article.
August 10, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28791558/zar1-knockdown-promotes-the-differentiation-of-human-neuroblastoma-cells-by-suppression-of-mycn-expression
#13
Yosuke Watanabe, Yoshiaki Ishizuka, Takayuki Hirano, Eri Nagasaki-Maeoka, Reina Hoshi, Shinsuke Yoshizawa, Shota Uekusa, Hiroyuki Kawashima, Kiminobu Sugito, Kenichi Shinohara, Noboru Fukuda, Hiroki Nagase, Masayoshi Soma, Tsugumichi Koshinaga, Kyoko Fujiwara
Although DNA hypermethylation at non-promoter region of the Zygote arrest 1 (ZAR1) gene has been observed in many types of tumor, including neuroblastoma (NB), the role of this gene in tumor development and/or progression is unclear. One reason is that knowledge about the function of ZAR1 protein is limited. Although it has been reported that ZAR1 plays a crucial role in early embryogenesis and may act as a transcriptional repressor for some transcripts, the detailed mechanism is still elusive. In the present study, we analyzed public data of NB patients and found that higher expression levels of ZAR1 were significantly associated with a shorter survival period...
August 8, 2017: Medical Oncology
https://www.readbyqxmd.com/read/28782421/epidemiologic-survey-of-feline-leukemia-virus-in-domestic-cats-on-tsushima-island-japan-management-strategy-for-tsushima-leopard-cats
#14
Isaac Makundi, Yushi Koshida, Kyohei Kuse, Takahiro Hiratsuka, Jumpei Ito, Takuya Baba, Shinya Watanabe, Maki Kawamura, Yuka Odahara, Ariko Miyake, Hanae Yamamoto, Sawako Kuniyoshi, Manabu Onuma, Kazuo Nishigaki
The Tsushima leopard cat (TLC) Prionailurus bengalensis euptilurus, a subspecies of P. bengalensis, is designated a National Natural Monument of Japan, and lives only on Tsushima Island, Nagasaki Prefecture, Japan. TLCs are threatened by various infectious diseases. Feline leukemia virus (FeLV) causes a serious infectious disease with a poor prognosis in cats. Therefore, the transmission of FeLV from Tsushima domestic cats (TDCs) to TLCs may threaten the TLC population. We investigated the FeLV infection status of both TDCs and TLCs on Tsushima Island by screening blood samples for FeLV p27 antigen and using PCR to amplify the full-length FeLV env gene...
August 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28775299/construction-and-evaluation-of-two-computational-models-for-predicting-the-incidence-of-influenza-in-nagasaki-prefecture-japan
#15
Fei He, Zhi-Jian Hu, Wen-Chang Zhang, Lin Cai, Guo-Xi Cai, Kiyoshi Aoyagi
It remains challenging to forecast local, seasonal outbreaks of influenza. The goal of this study was to construct a computational model for predicting influenza incidence. We built two computational models including an Autoregressive Distributed Lag (ARDL) model and a hybrid model integrating ARDL with a Generalized Regression Neural Network (GRNN), to assess meteorological factors associated with temporal trends in influenza incidence. The modelling and forecasting performance of these two models were compared using observations collected between 2006 and 2015 in Nagasaki Prefecture, Japan...
August 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28768959/next-generation-sequencing-based-mutation-screening-of-86-patients-with-idiopathic-short-stature
#16
Atsushi Hattori, Yuko Katoh-Fukui, Akie Nakamura, Keiko Matsubara, Tsutomu Kamimaki, Hiroyuki Tanaka, Sumito Dateki, Masanori Adachi, Koji Muroya, Shinobu Yoshida, Shinobu Ida, Marie Mitani, Keisuke Nagasaki, Tsutomu Ogata, Erina Suzuki, Kenichiro Hata, Kazuhiko Nakabayashi, Yoichi Matsubara, Satoshi Narumi, Toshiaki Tanaka, Maki Fukami
Although mutations in ACAN, FGFR3, NPR2, and SHOX typically lead to skeletal dysplasia, and mutations in GHRHR, GH1, GHR, STAT5B, IGF1, IGFALS, and IGF1R usually underlie hormonal defects of the growth hormone (GH)-insulin-like growth factor 1 (IGF1) axis, such mutations have also been identified in patients with idiopathic short stature (ISS). Of these, SHOX abnormalities are known to account for a certain percentage of ISS cases, whereas the frequency of mutations in the other 10 genes in ISS cohorts remains unknown...
August 3, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28744186/breeding-of-a-new-potato-variety-nagasaki-kogane-with-high-eating-quality-high-carotenoid-content-and-resistance-to-diseases-and-pests
#17
Yu Sakamoto, Kazuyuki Mori, Yuuki Matsuo, Nobuhiro Mukojima, Wataru Watanabe, Norio Sobaru, Seiji Tamiya, Takashi Nakao, Kazuya Hayashi, Hitomi Watanuki, Kazuhiro Nara, Kaoru Yamazaki, Masataka Chaya
'Nagasaki Kogane' is a new potato variety bred from a cross between 'Saikai 35' as a female parent and 'Saikai 33' as a male. 'Saikai 35' is resistant to bacterial wilt, contains the H1 and Rychc genes for resistance to the potato cyst nematode (PCN) and potato virus Y (PVY), respectively, and has high carotenoid content, while 'Saikai 33' has large and high-yielding tubers and is resistant to both bacterial wilt and PCN. The carotenoid content of 'Nagasaki Kogane' is higher than that of 'Dejima', a common double cropping variety...
June 2017: Breeding Science
https://www.readbyqxmd.com/read/28744040/an-estimation-of-knee-and-ankle-joint-angles-during-extension-phase-of-standing-up-motion-performed-using-an-inertial-sensor
#18
Fang Jin, Takayuki Nagasaki, Chikamune Wada
[Purpose] Motion capture system is difficult to use in daily life. The aim of this study was to propose an estimation model for knee and ankle joint angle measurements and locate body center of gravity (COG) of the extension phase during standing-up motion. [Subjects and Methods] Seven healthy male volunteers were enrolled. An estimation model was proposed for the knee and ankle joint angle measurements by combining the angle and acceleration of the trunk, based on readings from the inertial sensor attachment on the subject's chest, during the extension phase...
July 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28743058/oral-nanotherapeutics-redox-nanoparticles-attenuate-ultraviolet-b-radiation-induced-skin-inflammatory-disorders-in-kud-hr-hairless-mice
#19
Chitho P Feliciano, Yukio Nagasaki
The active participation of an anti-inflammatory drug in the biological pathways of inflammation is crucial for the achievement of beneficial and therapeutic effects. This study demonstrated the development of redox nanoparticles that can circulate in the blood at significantly high levels, thus increasing their efficacy as an oral treatment against the deleterious effects of reactive oxygen species (ROS) in an in vivo inflammatory skin model. To confirm the blood bioavailability of the nanoparticles, mice were injected with the nanoparticles solution (RNP(N)) via oral gavage...
October 2017: Biomaterials
https://www.readbyqxmd.com/read/28741751/assessment-of-diastolic-function-of-normal-fetal-heart-using-the-dual-gate-doppler-method
#20
Mayumi Takano, Masahiko Nakata, Sumito Nagasaki, Rei Ueyama, Mineto Morita
OBJECTIVES: The ratio of mitral peak early diastolic filling to early diastolic mitral annular velocity (E/e') reflects diastolic cardiac function in adults. The Dual gate Doppler (DD) method enables measurements of E/e' in the same heartbeat. This study was designed to assess the utility of the DD method for measurement of fetal E/e', and to determine reference ranges for normal fetuses. METHODS: This prospective study comprised normal singleton pregnancies between 16 and 36 weeks of gestational age (GA)...
July 25, 2017: Ultrasound in Obstetrics & Gynecology
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