keyword
MENU ▼
Read by QxMD icon Read
search

Japan

keyword
https://www.readbyqxmd.com/read/27911297/sample-size-estimation-for-alzheimer-s-disease-trials-from-japanese-adni-serial-magnetic-resonance-imaging
#1
Motonobu Fujishima, Atsushi Kawaguchi, Norihide Maikusa, Ryozo Kuwano, Takeshi Iwatsubo, Hiroshi Matsuda
BACKGROUND: Little is known about the sample sizes required for clinical trials of Alzheimer's disease (AD)-modifying treatments using atrophy measures from serial brain magnetic resonance imaging (MRI) in the Japanese population. OBJECTIVE: The primary objective of the present study was to estimate how large a sample size would be needed for future clinical trials for AD-modifying treatments in Japan using atrophy measures of the brain as a surrogate biomarker...
November 28, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27910964/osimertinib-a-third-generation-tyrosine-kinase-inhibitor-targeting-non-small-cell-lung-cancer-with-egfr-t790m-mutations
#2
C E McCoach, A Jimeno
Oncogenic driver mutations in the epidermal growth factor receptor (EGFR) gene have provided a focus for effective targeted therapy. Unfortunately, all patients eventually develop resistance to frontline therapy with EGFR tyrosine kinase inhibitors (TKIs). The majority of patients develop a large subclonal population of tumor cells with a T790M mutation that renders these cells resistant to first-generation TKIs. Osimertinib is a third-generation EGFR TKI that was designed to overcome resistance from T790M mutations...
October 2016: Drugs of Today
https://www.readbyqxmd.com/read/27910962/baricitinib-jak-inhibition-for-rheumatoid-arthritis
#3
J Gras
Rheumatoid arthritis (RA), a chronic autoimmune inflammatory disease characterized by inflammation and joint destruction, is associated with pain, progressive disability, systemic comorbidities and early death. Conventional disease-modifying antirheumatic drugs (DMARDs) and biological DMARDs (bDMARDs) have been able to achieve remission or a very low disease activity status for RA. Nevertheless, since many patients do not reach a sufficient response with DMARDs or present with unacceptable side effects, new therapies are needed...
October 2016: Drugs of Today
https://www.readbyqxmd.com/read/27910113/diagnostic-accuracy-of-faecal-biomarkers-in-detecting-colorectal-cancer-and-adenoma-in-symptomatic-patients
#4
M M Widlak, C L Thomas, M G Thomas, C Tomkins, S Smith, N O'Connell, S Wurie, L Burns, C Harmston, C Evans, C U Nwokolo, B Singh, R P Arasaradnam
BACKGROUND: The diagnosis of colorectal cancer (CRC) can be difficult as symptoms are variable with poor specificity. Thus, there is a quest for simple, non-invasive testing that can help streamline those with significant colonic pathology. AIM: To assess using faecal immunochemical test for haemoglobin (FIT) or faecal calprotectin (FCP) to detect CRC and adenoma in symptomatic patients referred from primary care. METHODS: A total of 799 referred for urgent lower gastrointestinal investigations were prospectively recruited...
December 1, 2016: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27909987/orexin-ox2-receptor-antagonists-as-sleep-aids
#5
Laura H Jacobson, Sui Chen, Sanjida Mir, Daniel Hoyer
The discovery of the orexin system represents the single major progress in the sleep field of the last three to four decades. The two orexin peptides and their two receptors play a major role in arousal and sleep/wake cycles. Defects in the orexin system lead to narcolepsy with cataplexy in humans and dogs and can be experimentally reproduced in rodents. At least six orexin receptor antagonists have reached Phase II or Phase III clinical trials in insomnia, five of which are dual orexin receptor antagonists (DORAs) that target both OX1 and OX2 receptors (OX2Rs)...
December 2, 2016: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/27909835/breakthrough-chemotherapy-induced-nausea-and-vomiting-report-of-a-nationwide-survey-by-the-cinv-study-group-of-japan
#6
Kazuo Tamura, Keisuke Aiba, Toshiaki Saeki, Yoichi Nakanishi, Toshiharu Kamura, Hideo Baba, Kazuhiro Yoshida, Nobuyuki Yamamoto, Yuko Kitagawa, Yoshihiko Maehara, Mototsugu Shimokawa, Koichi Hirata, Masaki Kitajima
BACKGROUND: We conducted a nationwide survey on chemotherapy-induced nausea and vomiting (CINV) in Japan and demonstrated good compliance with Japanese CINV guidelines, resulting in good control of vomiting. However, almost half the patients experienced breakthrough CINV. We analyzed the survey results in relationship to the management of patients with breakthrough CINV. METHODS: This multicenter, prospective, observational study analyzed data for 1910 patients in Japan scheduled for moderately or highly emetogenic chemotherapy (MEC and HEC, respectively)...
December 1, 2016: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27909736/discovery-and-history-of-amino-acid-fermentation
#7
Shin-Ichi Hashimoto
There has been a strong demand in Japan and East Asia for L-glutamic acid as a seasoning since monosodium glutamate was found to present umami taste in 1907. The discovery of glutamate fermentation by Corynebacterium glutamicum in 1956 enabled abundant and low-cost production of the amino acid, creating a large market. The discovery also prompted researchers to develop fermentative production processes for other L-amino acids, such as lysine. Currently, the amino acid fermentation industry is so huge that more than 5 million metric tons of amino acids are manufactured annually all over the world, and this number continues to grow...
December 2, 2016: Advances in Biochemical Engineering/biotechnology
https://www.readbyqxmd.com/read/27909153/comparison-of-the-high-energy-photon-reference-fields-of-ptb-and-jaea
#8
H Zutz, M Kowatari, O Hupe
A comparison has been conducted between the 6 MeV and 7 MeV (R-F) high-energy photon reference fields of the Physikalisch-Technische Bundesanstalt (PTB) and the Japan Atomic Energy Agency (JAEA). Both fields are set up according to ISO 4037. The results of both participants are in agreement within the combined uncertainties, thus the equivalence of the measurements is demonstrated.
November 30, 2016: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/27908979/secondhand-smoke-exposure-and-risk-of-lung-cancer-in-japan-a-systematic-review-and-meta-analysis-of-epidemiologic-studies
#9
Satoru Shikata, Yousuke Takemura
No abstract text is available yet for this article.
December 1, 2016: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27908922/stomach-cancer-disparity-among-korean-americans-by-tumor-characteristics-comparison-with-non-hispanic-whites-japanese-americans-south-koreans-and-japanese
#10
Eunjung Lee, Lihua Liu, Juanjuan Zhang, Mariana C Stern, Afsaneh Barzi, Amie E Hwang, Andre E Kim, Ann S Hamilton, Anna H Wu, Dennis Deapen
BACKGROUND: Stomach cancer incidence shows substantial racial-ethnic disparity in the United States (US), with Korean Americans experiencing by far the highest incidence. We examined stomach cancer incidence trends in Korean Americans by tumor subsite, histology and stage, and compared them with incidence rates in racial-ethnic groups with the second highest rate (Japanese Americans) and the lowest rate (non-Hispanic whites; NHWs) as well as populations in South Korea and Japan. METHODS: We calculated age-adjusted incidence rates by racial-ethnic groups and sex, by tumor characteristics, using the 1988-2012 California Cancer Registry data...
December 1, 2016: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/27907015/weight-gain-in-survivors-living-in-temporary-housing-in-the-tsunami-stricken-area-during-the-recovery-phase-following-the-great-east-japan-earthquake-and-tsunami
#11
Shuko Takahashi, Yuki Yonekura, Ryohei Sasaki, Yukari Yokoyama, Kozo Tanno, Kiyomi Sakata, Akira Ogawa, Seichiro Kobayashi, Taro Yamamoto
INTRODUCTION: Survivors who lost their homes in the Great East Japan Earthquake and Tsunami were forced to live in difficult conditions in temporary housing several months after the disaster. Body weights of survivors living in temporary housing for a long period might increase due to changes in their life style and psychosocial state during the medium-term and long-term recovery phases. The aim of this study was to determine whether there were differences between body weight changes of people living in temporary housing and those not living in temporary housing in a tsunami-stricken area during the medium-term and long-term recovery phases...
2016: PloS One
https://www.readbyqxmd.com/read/27906457/comparison-of-survival-times-for-dogs-with-pituitary-dependent-hyperadrenocorticism-in-a-primary-care-hospital-treated-with-trilostane-versus-untreated
#12
N Nagata, K Kojima, M Yuki
BACKGROUND: Although pituitary-dependent hyperadrenocorticism (PDH) is one of the most common endocrinopathies in dogs, the effects of withholding treatment on survival time in dogs with PDH remain unclear. HYPOTHESIS/OBJECTIVES: The purpose of this study was to clarify the effects of treatment in dogs with PDH by comparing survival times between dogs treated with trilostane and untreated dogs. ANIMALS: Forty-three dogs diagnosed with PDH at a primary-care hospital in Japan between June 2009 and January 2014...
December 1, 2016: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/27906440/supramicrosurgical-lymphatico-venular-anastomosis-lva-in-treating-lymphoedema-36-months-preliminary-report
#13
P Gennaro, G Gabriele, M Mihara, K Kikuchi, C Salini, I Aboh, F Cascino, G Chisci, C Ungari
OBJECTIVE: Lymphoedema of the extremities is a widespread pathological condition that mostly occurs as a complication of cancer resections, especially in women. Conventional therapy refers to conservative and physiotherapeutic approaches. Surgical strategies have been widely reported in the literature and are still challenging. Part of this literature focuses on the supra microsurgical lymphaticovenular anastomosis (LVA) technique. LVA is characterized by a high success rate, minimal invasivity and broad indications...
November 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27905965/socioeconomic-status-and-self-rated-health-of-japanese-people-based-on-age-cohort-and-period
#14
Hidehiro Sugisawa, Ken Harada, Yoko Sugihara, Shizuko Yanagisawa, Masaya Shinmei
BACKGROUND: Differences in health resulting from differences in socioeconomic status (SES) have been identified around the world. Age, period, and cohort (A-P-C) differences in health are vital factors which are associated with disparities in SES. However, few studies have examined these differences simultaneously. Moreover, although self-rated health (SRH) has been frequently used as an indicator of health, biases in reporting SRH that depend on the socioeconomic characteristics of respondents have been scarcely adjusted in the previous studies...
August 2, 2016: Population Health Metrics
https://www.readbyqxmd.com/read/27905950/use-of-indocyanine-green-and-the-hypereye-system-for-detecting-sentinel-lymph-nodes-in-breast-cancer-within-a-population-of-european-patients-a-pilot-study
#15
Oldřich Coufal, Vuk Fait
BACKGROUND: Certain studies suggest that using indocyanine green (ICG) could be comparable with using radioisotopes (RI) in detecting sentinel lymph nodes (SLNs) in breast cancer. A number of these studies were performed in Asia. The objective of our pilot study was to evaluate within a European population of breast cancer patients the detection rate of SLNs using ICG and the HyperEye system and the concordance in SLNs detected using this method and the standard method involving RI and a gamma probe...
December 1, 2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27905948/changes-in-life-expectancy-1950-2010-contributions-from-age-and-disease-specific-mortality-in-selected-countries
#16
Jochen Klenk, Ulrich Keil, Andrea Jaensch, Marcus C Christiansen, Gabriele Nagel
BACKGROUND: Changes of life expectancy over time serve as an interesting public health indicator for medical, social and economic developments within populations. The aim of this study was to quantify changes of life expectancy between 1950 and 2010 and relate these to main causes of death. METHODS: Pollard's actuarial method of decomposing life expectancy was applied to compare the contributions of different age- and disease-groups on life expectancy in 5-year intervals...
May 23, 2016: Population Health Metrics
https://www.readbyqxmd.com/read/27905911/prevalence-of-lumbar-spondylosis-and-its-association-with-low-back-pain-among-community-dwelling-japanese-women
#17
Ritsu Tsujimoto, Yasuyo Abe, Kazuhiko Arima, Takayuki Nishimura, Masato Tomita, Akihiko Yonekura, Takashi Miyamoto, Shohei Matsubayashi, Natsumi Tanaka, Kiyoshi Aoyagi, Makoto Osaki
BACKGROUND: Lumbar spondylosis is more prevalent among the middle-aged and elderly, but few population-based studies have been conducted, especially in Japan. The purpose of this study was to explore the prevalence of lumbar spondylosis and its associations with low back pain among community-dwelling Japanese women. METHODS: Lateral radiographs of the lumbar spine were obtained from 490 Japanese women ≥ 40 years old, and scored for lumbar spondylosis using the Kellgren-Lawrence (KL) grade at lumbar intervertebral level from L1/2 to L5/S1...
December 1, 2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27905819/mothers-preferences-regarding-new-combination-vaccines-for-their-children-in-japan-2014
#18
Aiko Shono, Masahide Kondo
A number of new vaccines to prevent childhood diseases have been introduced globally over the last few decades. Only four combination vaccines are currently available in Japan, DTaP/sIPV, DTaP, DT, and MR, leading to complex infant vaccine scheduling. This study aims to investigate mothers' preferences with respect to combination vaccines for their children, should new combination vaccines become available that have not yet been launched in Japan or that will be developed in the future. We conducted a web-based, cross-sectional survey of 1,243 mothers who had at least one child between 2 months and 3 years of age...
December 1, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27905487/a-possible-space-based-tsunami-early-warning-system-using-observations-of-the-tsunami-ionospheric-hole
#19
Masashi Kamogawa, Yoshiaki Orihara, Chiaki Tsurudome, Yuto Tomida, Tatsuya Kanaya, Daiki Ikeda, Aditya Riadi Gusman, Yoshihiro Kakinami, Jann-Yenq Liu, Atsushi Toyoda
Ionospheric plasma disturbances after a large tsunami can be detected by measurement of the total electron content (TEC) between a Global Positioning System (GPS) satellite and its ground-based receivers. TEC depression lasting for a few minutes to tens of minutes termed as tsunami ionospheric hole (TIH) is formed above the tsunami source area. Here we describe the quantitative relationship between initial tsunami height and the TEC depression rate caused by a TIH from seven tsunamigenic earthquakes in Japan and Chile...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27905404/application-of-profile-fitting-method-to-neutron-time-of-flight-protein-single-crystal-diffraction-data-collected-at-the-ibix
#20
Naomine Yano, Taro Yamada, Takaaki Hosoya, Takashi Ohhara, Ichiro Tanaka, Katsuhiro Kusaka
We developed and employed a profile fitting method for the peak integration of neutron time-of-flight diffraction data collected by the IBARAKI Biological Crystal Diffractometer (iBIX) at the Japan Proton Accelerator Research Complex (J-PARC) for protein ribonuclease A and α-thrombin single crystals. In order to determine proper fitting functions, four asymmetric functions were evaluated using strong intensity peaks. A Gaussian convolved with two back-to-back exponentials was selected as the most suitable fitting function, and a profile fitting algorithm for the integration method was developed...
December 1, 2016: Scientific Reports
keyword
keyword
32776
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"