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https://www.readbyqxmd.com/read/29050030/concluding-remarks
#1
Marcela Rocha de Olivera Carrilho
Case reports and clinical trials conducted in different countries (i.e., the United States, Canada, Brazil, Germany, Finland, Sweden, Japan, India, and Sri Lanka) tend to find a positive relationship between the presence of more retained teeth in older ages and the prevalence of root caries in older adults. As this tendency has been shown to prevail globally, it is estimated that the predicted demographic elderly expansion may cause, in near future, a significant increment in the number of older population requiring an effective means of preventing and treating root surface caries...
2017: Monographs in Oral Science
https://www.readbyqxmd.com/read/29049955/the-engine-and-the-reaper-industrialization-and-mortality-in-late-nineteenth-century-japan
#2
John P Tang
Economic development improves long-run health outcomes through access to medical treatment, sanitation, and higher income. Short run impacts, however, may be ambiguous given disease exposure from market integration. Using a panel dataset of Japanese vital statistics and multiple estimation methods, I find that railroad network expansion is associated with a six percent increase in gross mortality rates among newly integrated regions. Communicable diseases accounted for most of the rail-associated mortality, which indicate railways behaved as transmission vectors...
September 11, 2017: Journal of Health Economics
https://www.readbyqxmd.com/read/29049375/intratumoral-heterogeneity-of-programmed-cell-death-ligand-1-expression-is-common-in-lung-cancer
#3
Sayuri Nakamura, Kentaro Hayashi, Yuki Imaoka, Yuka Kitamura, Yuko Akazawa, Kazuhiro Tabata, Ruben Groen, Tomoshi Tsuchiya, Naoya Yamasaki, Takeshi Nagayasu, Junya Fukuoka
Programmed cell death ligand-1 (PD-L1) expression may predict the response to both programmed cell death-1 and PD-L1 inhibitors in lung cancer. However, the extent of intratumoral heterogeneity of PD-L1 expression, which may cause false negative results, is largely unexplored. We aimed to assess the intratumoral heterogeneity of PD-L1 expression in surgically resected lung cancer specimens by applying a novel method of tissue microarray, namely Spiral Arrays, which enables us to observe the heterogeneity in spiral-shaped tissue cores...
2017: PloS One
https://www.readbyqxmd.com/read/29049248/item-response-theory-based-validation-of-a-short-form-of-the-eating-behavior-scale-for-japanese-adults
#4
Jun Tayama, Sayaka Ogawa, Atsushi Takeoka, Masakazu Kobayashi, Susumu Shirabe
Obesity has become a serious social problem in industrialized countries in recent years. Clinically, although the evaluation of dietary behavior abnormalities is as important as any method of risk assessment for obesity, almost all the existing scales with many items may have numerous practical clinical difficulties. In this study, we aimed to prepare a short questionnaire to assess the dietary behavior abnormalities related to obesity. A total of 1032 individuals aged 20 to 59 years participated in the present study...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29049206/the-molecular-epidemiology-of-respiratory-viruses-associated-with-asthma-attacks-a-single-center-observational-study-in-japan
#5
Takeshi Saraya, Hirokazu Kimura, Daisuke Kurai, Haruyuki Ishii, Hajime Takizawa
Few reports have described the significance of viral respiratory infections (VRIs) in exacerbation of asthma in adult patients. The aim of this study was to elucidate the profiles of VRIs in adult patients with asthma along with their molecular epidemiology.A cross-sectional observational study was conducted at Kyorin University Hospital from August 2012 to May 2015. To identify respiratory pathogens in inpatients and outpatients suffering from asthma attacks, RT-PCR/sequencing/phylogenetic analysis methods were applied alongside conventional microbiological methods...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29049047/analysis-of-radionuclide-deposition-ratios-from-the-fukushima-daiichi-incident
#6
C M Marianno, M R Smith, K M Cook
This paper will examine deposition patterns of four radionuclides following the Fukushima-Daiichi accident. For nearly 13 d following the event, fission products were released into the environment through planned venting procedures and hydrogen explosions. To assist the government of Japan (GOJ) in the assessment of the releases, the National Nuclear Security Administration's Consequence Management Response Team (CMRT) deployed and took nearly 3 mo of measurements using airborne radiation sensors, fixed monitors, high purity germanium (HPGe) detectors, and health physics survey equipment...
October 18, 2017: Health Physics
https://www.readbyqxmd.com/read/29048932/cardio-ankle-vascular-index-value-in-dyslipidemia-patients-affected-by-cardiovascular-risk-factors
#7
XiaoXiao Zhao, Liujin Bo, Hongwei Zhao, Lihong Li, Yingyan Zhou, Hongyu Wang
BACKGROUND: Increased arterial stiffness is an independent cardiovascular risk factor in smokers or patients with diabetes mellitus and hypertension. Cardio-ankle vascular index (CAVI) is an index of arterial stiffness and atherosclerosis. One of the most important risk factors of the causes of atherosclerosis is dyslipidemia(DLP). However, there was a little research about which influence factors such as: hypertension, diabetes mellitus, and smoking could contribute to the atherosclerosis in the subjects withDLP...
October 19, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29047408/the-efficacy-of-the-kampo-medicine-rikkunshito-for-chemotherapy-induced-anorexia-rich-trial-study-protocol-for-a-randomized-controlled-trial
#8
Takuya Inoue, Hironori Takagi, Yuki Owada, Yuzuru Watanabe, Takumi Yamaura, Mitsuro Fukuhara, Satoshi Muto, Naoyuki Okabe, Yuki Matsumura, Takeo Hasegawa, Jun Osugi, Mika Hoshino, Mitsunori Higuchi, Yutaka Shio, Hiroshi Yokouchi, Kenya Kanazawa, Katsuya Ohbuchi, Takahisa Fukushima, Mitsuru Munakata, Hiroyuki Suzuki
BACKGROUND: Cisplatin is a key drug in lung cancer therapy. However, cisplatin is also well known to induce gastrointestinal disorders, such as chemotherapy-induced nausea and vomiting, anorexia, and weight loss. These symptoms sometimes affect patients' quality of life and make continuation of chemotherapy difficult. Anorexia is a cause of concern for patients with cancer because a persistent loss of appetite progresses to cancer cachexia. Although evidence-based management for chemotherapy has recently been established, there is room for improvement...
October 18, 2017: Trials
https://www.readbyqxmd.com/read/29047351/lifestyle-factors-are-significantly-associated-with-the-locomotive-syndrome-a-cross-sectional-study
#9
Manabu Akahane, Shingo Yoshihara, Akie Maeyashiki, Yasuhito Tanaka, Tomoaki Imamura
BACKGROUND: The Japanese Orthopedic Association first proposed the concept of "locomotive syndrome" in 2007. It refers to circumstances in which elderly people need nursing care services or are at high risk of requiring such services within a short time. Recently, the public health burden of providing nursing care for elderly individuals has increased. Therefore, locomotive syndrome, and the means of preventing it, are a major public health focus in Japan. The purpose of this study was to investigate the relationships of lifestyle factors, such as smoking, alcohol consumption, sleep duration, and dental health, with locomotive syndrome...
October 18, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/29047148/epidemiological-survey-of-patients-with-psoriasis-in-matsumoto-city-nagano-prefecture-japan
#10
Eisaku Ogawa, Ryuhei Okuyama, Tomoko Seki, Aya Kobayashi, Naoki Oiso, Masahiko Muto, Hidemi Nakagawa, Akira Kawada
A local epidemiological survey of psoriasis was conducted from 19 February to 30 June 2016 in Matsumoto city, Nagano Prefecture, Japan. Patients were predominantly male (268 cases, 71.5% males vs 107 cases, 28.5% females). We estimated that the prevalence of psoriasis was 0.097% in the Matsumoto area. The clinical types of psoriasis identified were psoriasis vulgaris (90.7%), psoriatic arthritis (5.9%), pustular psoriasis (2.1%), guttate psoriasis (1.0%) and psoriatic erythroderma (0.3%). The topical therapeutic agents included corticosteroids (84...
October 19, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/29047146/incidence-and-risk-factors-of-colorectal-cancer-based-on-56-324-health-checkups-7-years-retrospective-cohort-study
#11
Toshiko Fujii, Masayuki Ohisa, Toru Sako, Takayuki Harakawa, Kazuaki Sakanume, Shintaro Nagashima, Aya Sugiyama, Yuuichiro Matsuura, Junko Tanaka
BACKGROUND AND AIM: Although mortality rates of colorectal cancer (CRC) have been increasing in Japan, its screening rates remain stagnant at 19.2% among Japanese population aged >40 years in 2014. To evaluate the importance of CRC screening by fecal occult blood test (FOBT), we estimated the incidence of FOBT-positivity and CRC by sex-age stratification and clarified the risk factors for CRC. METHODS: Between 2007 and 2014, 56,324 residents (21,517 men and 34,807 women) were enrolled in this study...
October 19, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29046794/palliative-surgery-for-giant-mucinous-carcinoma-of-the-breast-in-an-elderly-patient-a-rare-case-report
#12
Haruko Takuwa, Wakako Tsuji, Fumiaki Yotsumoto
Mucinous breast carcinoma (MBC) is relatively rare, accounting for <10% of all breast cancers in women. These tumors are usually slow-growing and exhibit less aggressive characteristics compared with other types of breast cancer. Between 1989 and 2016, 55 patients underwent surgery for MBC at the Shiga Medical Center for Adults (Moriyama, Japan). The 10-year disease-free survival (DFS) and overall survival rates were 94.5 and 100.0%, respectively. Specifically, the 10-year DFS rates of pure MBC (PMBC) and mixed MBC were 97...
October 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29046791/evaluation-of-safety-feasibility-and-the-long-term-outcomes-of-colorectomy-for-colorectal-adenocarcinoma-in-patients-older-than-80-years-of-age
#13
Norio Yukawa, Toru Aoyama, Tsutomu Sato, Takashi Oshima, Takaki Yoshikawa, Yasushi Rino, Munetaka Masuda
The short- and long-term outcomes of colorectomy for colorectal adenocarcinoma have not been fully evaluated in elderly patients. The present retrospective study investigated patients who underwent curative surgery for colorectal cancer at the Department of Surgery, Yokohama City University (Yokohoma, Japan). The patients were categorized into two groups: Elderly patients (70-79 years of age; group A) and extremely elderly patients (≥80 years of age; group B). The rates of surgical morbidity, surgical mortality, overall survival (OS), and recurrence-free survival (RFS) in the two groups were compared...
October 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29046737/between-the-west-and-asia-humanistic-japanese-family-planning-in-the-cold-war
#14
Aya Homei
This paper studies the formation of Japanese ventures in family planning deployed in various villages in Asia from the 1960s onward in the name of development aid. By critically examining how Asia became the priority area for Japan's international cooperation in family planning and by analyzing how the adjective "humanistic" was used to underscore the originality of Japan's family planning program overseas, the paper shows that visions of Japanese actors were directly informed by Japan's delicate position in Cold War geopolitics, between the imagined West represented by the United States and "underdeveloped" Asia, at a time when Japan was striving to (re-)establish its position in world politics and economics...
December 2016: East Asian Science, Technology and Society
https://www.readbyqxmd.com/read/29046701/safety-of-8-weeks-oral-administration-of-arctium-lappa-l
#15
So-Hyeon Bok, Seung Sik Cho, Chun-Sik Bae, Dae-Hun Park, Kyung-Mok Park
Recently, worldwide dietary reference intakes have been considered an important guideline for public health. Some governments and the World Health Organization (WHO) provide guidelines concerning dietary intake. Although an ingredient may have a history of use as a culinary material, changes in the environment over time suggest that the acceptable maximum intake each of food/culinary material should be regularly evaluated. Arctium lappa L. has been used as a culinary material for many centuries in Korea and Japan and some recent studies have reported related therapeutic effects...
September 2017: Laboratory Animal Research
https://www.readbyqxmd.com/read/29046698/evaluation-of-in-vitro-and-in-vivo-genotoxicity-of-angelica-acutiloba-in-a-standard-battery-of-assays
#16
Jun-Won Yun, Yun-Soon Kim, Euna Kwon, Seung-Hyun Kim, Ji-Ran You, Hyeon Hoe Kim, Jeong-Hwan Che, Byeong-Cheol Kang
Among three representative species of Angelica found in Asian countries, including Korea, China, and Japan, Angelica acutiloba (AA) has been used as traditional herbal medicine with antitumor, anti-inflammatory, anti-obesity, and anti-diabetes activities. In this study, the potential genotoxicity and mutagenicity of the AA extract were examined in a battery of in vitro and in vivo tests (bacterial reverse mutation assay, in vitro chromosomal aberrations assay, and in vivo micronucleus assay) in accordance with the test guidelines for toxicity testing developed by the Organization for Economic Cooperation and Development...
September 2017: Laboratory Animal Research
https://www.readbyqxmd.com/read/29046512/guidelines-for-personal-exposure-monitoring-of-chemicals-part-ii
#17
Haruo Hashimoto, Kenichi Yamada, Hajime Hori, Shinji Kumagai, Masaru Murata, Toshio Nagoya, Hirohiko Nakahara, Nobuyuki Mochida
This Document, "Guidelines for personal exposure monitoring of chemicals" ("this Guideline"), has been prepared by "The Committee for Personal Exposure Monitoring" ("the Committee") of the Expert Division of Occupational Hygiene & Ergonomics, Japan Society for Occupational Health. Considering the background of the growing importance of personal exposure monitoring in risk assessment and the need to prepare for the introduction of monitoring using personal samplers from an administrative perspective in recent years, the Committee was organized in November 2012...
October 18, 2017: Journal of Occupational Health
https://www.readbyqxmd.com/read/29046502/correlation-between-thyroid-stimulating-hormone-and-renal-function-in-euthyroid-residents-of-japan-results-from-the-kyushu-and-okinawa-population-study-kops
#18
Yuki Tanaka, Norihiro Furusyo, Yoshifumi Kato, Takatsugu Ueyama, Sho Yamasaki, Hiroaki Ikezaki, Masayuki Murata, Jun Hayashi
AIM: The present large-scale Japanese population study was performed to evaluate the relation between the serum thyroid stimulating hormone (TSH) level and renal function. METHODS: Out of 1,374 residents who participated in a free public physical examination between 2010 and 2011, we evaluated the data of 888 participants for whom the serum TSH level and estimated glomerular filtration rate (eGFR) were successfully measured. The participants were categorized into three groups based on TSH levels (normal TSH, ≤2...
October 18, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29046501/characterization-of-amylolytic-enzyme-overproducing-mutant-of-aspergillus-luchuensis-obtained-by-ion-beam-mutagenesis
#19
Toshihiro Kojo, Chihiro Kadooka, Marisa Komohara, Shiori Onitsuka, Miya Tanimura, Yukiko Muroi, Shugo Kurazono, Yohei Shiraishi, Ken Oda, Kazuhiro Iwashita, Masahira Onoue, Kayu Okutsu, Yumiko Yoshizaki, Kazunori Takamine, Taiki Futagami, Kazuki Mori, Hisanori Tamaki
Aspergillus luchuensis is a kuro (black) koji fungus that has been used as a starch degrader for the awamori- and shochu-making industries in Japan. In this study, we investigated the effect of ion beam irradiation on A. luchuensis RIB2601 and obtained a high starch-degrading mutant strain U1. Strain U1 showed reduced growth rate, whereas it showed higher α-amylase, glucoamylase, and α-glucosidase activities on a mycelial mass basis than the wild type (wt) strain both on agar plates and in rice koji. In addition, strain U1 showed higher N-acetylglucosamine content in the cell wall and higher sensitivity to calcofluor white, suggesting a deficiency in cell wall composition...
October 17, 2017: Journal of General and Applied Microbiology
https://www.readbyqxmd.com/read/29046434/aristolochic-acids-and-their-derivatives-are-widely-implicated-in-liver-cancers-in-taiwan-and-throughout-asia
#20
Alvin W T Ng, Song Ling Poon, Mi Ni Huang, Jing Quan Lim, Arnoud Boot, Willie Yu, Yuka Suzuki, Saranya Thangaraju, Cedric C Y Ng, Patrick Tan, See-Tong Pang, Hao-Yi Huang, Ming-Chin Yu, Po-Huang Lee, Sen-Yung Hsieh, Alex Y Chang, Bin T Teh, Steven G Rozen
Many traditional pharmacopeias include Aristolochia and related plants, which contain nephrotoxins and mutagens in the form of aristolochic acids and similar compounds (collectively, AA). AA is implicated in multiple cancer types, sometimes with very high mutational burdens, especially in upper tract urothelial cancers (UTUCs). AA-associated kidney failure and UTUCs are prevalent in Taiwan, but AA's role in hepatocellular carcinomas (HCCs) there remains unexplored. Therefore, we sequenced the whole exomes of 98 HCCs from two hospitals in Taiwan and found that 78% showed the distinctive mutational signature of AA exposure, accounting for most of the nonsilent mutations in known cancer driver genes...
October 18, 2017: Science Translational Medicine
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