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https://www.readbyqxmd.com/read/29667942/smoking-is-a-risk-factor-for-relapse-of-antimyeloperoxidase-antibodies-associated-vasculitis
#1
Makoto Yamaguchi, Masahiko Ando, Takayuki Katsuno, Naotake Tsuboi, Shoichi Maruyama
BACKGROUND/OBJECTIVE: Several studies have identified predictors of relapse in antineutrophil cytoplasmic antibody-associated small-vessel vasculitis. However, the role of smoking as a risk factor of relapse has not been elucidated. Therefore, this study aimed to evaluate whether a history of smoking is a dose-dependent independent risk factor for antineutrophil cytoplasmic antibody-associated small-vessel vasculitis relapse. METHODS: This multicenter retrospective cohort study included 122 patients with granulomatosis with polyangiitis and microscopic polyangiitis (MPA) from 9 nephrology centers in Japan...
April 5, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29667471/cost-effectiveness-analysis-of-suvorexant-for-the-treatment-of-japanese-elderly-patients-with-chronic-insnomnia-in-a-virtual-cohort
#2
Shinichi Nishimura, Mutsuhiro Nakao
AIMS: We assessed the cost effectiveness of the orexin receptor antagonist suvorexant against zolpidem, the most widely used hypnotic benzodiazepine receptor agonist in Japan. To this end, a model was used that factored in insomnia and the risk for hip fractures, which have devastating effects on the elderly. METHODS: Data were derived from published papers. The target population was a virtual cohort of elderly patients (≥65 years) with insomnia residing in Japan...
April 18, 2018: Journal of Medical Economics
https://www.readbyqxmd.com/read/29667360/menstrual-and-reproductive-factors-and-type-2-diabetes-risk-the-japan-public-health-center-based-prospective-study
#3
Akiko Nanri, Tetsuya Mizoue, Mitsuhiko Noda, Atsushi Goto, Norie Sawada, Shoichiro Tsugane
AIMS/INTRODUCTION: Menstrual and reproductive factors, including age at menarche, parity, and breastfeeding, have been linked to type 2 diabetes risk. We prospectively investigated the association between these factors and type 2 diabetes risk in a large Japanese cohort. MATERIALS AND METHODS: Participants were 37,511 women aged 45-75 years who participated in the baseline (1990-1993), second (1995-1998), and third surveys (2000-2003) of the Japan Public Health Center-based Prospective Study and who had no history of diabetes at the second survey...
April 18, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29667330/no-increased-risk-of-herpes-zoster-in-tnf-inhibitor-and-non-tnf-inhibitor-users-with-rheumatoid-arthritis-epidemiological-study-using-the-japanese-health-insurance-database
#4
Ryoko Sakai, Shoko Kasai, Fumio Hirano, Sayoko Harada, Mari Kihara, Waka Yokoyama, Michi Tsutsumino, Kenji Nagasaka, Ryuji Koike, Hisashi Yamanaka, Nobuyuki Miyasaka, Masayoshi Harigai
OBJECTIVE: It is controversial whether the use of biological disease-modifying antirheumatic drugs (DMARDs) increases the risk of herpes zoster (HZ). We aimed to evaluate the risks of HZ in tumor necrosis factor inhibitor (TNFI) and non-TNFI users with rheumatoid arthritis (RA) over 3 years in Japan. METHOD: Using the Japanese health insurance database, we assigned patients with at least one RA diagnostic code and one prescription for any DMARDs (RA cases) recorded between January 2005 and December 2013 to the RA group...
April 17, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29667314/the-diary-of-a-nonagenarian-centenarian-woman-with-dementia-memory-loss-life-changes-and-community-care-in-japan
#5
Sayuri Suwa, Saori Otani, Mayuko Tsujimura, Kotoko Nogawa, Yoko Shiya
AIM: This study aimed to explore the experiences and thoughts of a nonagenarian-centenarian woman with dementia living alone, through detailed analysis of her unsolicited diary. DATA SOURCE: After receiving consent from Aki (a pseudonym), her family and caregivers, copies of her diaries, hand-written in Japanese, were provided for analysis. METHODS: The content of the diaries was broadly organized into themes and qualitative content analysis carried out for each theme along a sequential timeline...
April 2018: International Journal of Nursing Practice
https://www.readbyqxmd.com/read/29667311/how-japanese-nurses-participate-in-decision-making-infants-with-congenital-life-threatening-conditions
#6
Sohei Shitaya, Nobue Nakamura, Naho Sato
BACKGROUND: In Japan, owing to the progress in medical technology, more children with congenital life-threatening conditions survive than ever before. Nurses who care for these children may also influence decision making in difficult situations. AIM: We aimed to describe Japanese nurses' approach toward medical decision making when caring for families of infants with congenital life-threatening conditions. Frequently, these nurses must care for and support parents with ambivalent feelings...
April 2018: International Journal of Nursing Practice
https://www.readbyqxmd.com/read/29667310/self-management-of-congestive-heart-failure-among-elderly-men-in-japan
#7
Motohiro Sano, Tomoko Majima
The purpose of this study was to explore the process of self-management in elderly male patients with congestive heart failure among those who have had not needed re-hospitalization for more than 2 years. Semi-structured interviews were conducted with 10 male congestive heart failure patients. Interviews were audio-recorded and transcribed verbatim. Data were analysed using the modified grounded theory approach. As a result of the analysis, the core concept identified was a process of living life such that symptoms do not worsen, while balancing good choices and preferences...
April 2018: International Journal of Nursing Practice
https://www.readbyqxmd.com/read/29667133/unique-characteristics-of-regulatory-approval-and-pivotal-studies-of-orphan-anticancer-drugs-in-japan
#8
Hiroki Nakayama, Katsura Tsukamoto
The approval of orphan anticancer drugs has increased, with the number exceeding that of non-orphan drugs in Japan in recent years. Although orphan anticancer drugs may have unique characteristics due to their rarity, these have not been fully characterized. We investigated anticancer drugs approved in Japan between April 2004 and November 2017 to reveal the characteristics of regulatory approval and pivotal studies on orphan anticancer drugs compared to non-orphan drugs. The median regulatory review time and number of patients in pivotal studies on orphan anticancer drugs (281...
April 17, 2018: Investigational New Drugs
https://www.readbyqxmd.com/read/29667107/a-computer-based-glucose-management-system-reduces-the-incidence-of-forgotten-glucose-measurements-a-retrospective-observational-study
#9
Tsuyoshi Okura, Kei Teramoto, Rie Koshitani, Yohei Fujioka, Yusuke Endo, Masaru Ueki, Masahiko Kato, Shin-Ichi Taniguchi, Hiroshi Kondo, Kazuhiro Yamamoto
INTRODUCTION: Frequent glucose measurements are needed for good blood glucose control in hospitals; however, this requirement means that measurements can be forgotten. We developed a novel glucose management system using an iPod® and electronic health records. METHODS: A time schedule system for glucose measurement was developed using point-of-care testing, an iPod® , and electronic health records. The system contains the glucose measurement schedule and an alarm sounds if a measurement is forgotten...
April 17, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29667034/thermal-comfort-along-the-marathon-course-of-the-2020-tokyo-olympics
#10
Tsuyoshi Honjo, Yuhwan Seo, Yudai Yamasaki, Nobumitsu Tsunematsu, Hitoshi Yokoyama, Hiroaki Yamato, Takehiko Mikami
The Olympic Games will be held in Tokyo in 2020 and the period will be the hottest period of the year in Japan. Marathon is a sport with a large heat load, and it is said that the risk of heat stroke rises more than other sports activities. The thermal environment of the 2020 Tokyo Olympic marathon course is analyzed by using wet-bulb globe temperature (WBGT) and Universal Thermal Climate Index (UTCI) map of the center area of Tokyo. The change due to the place, the effect of the shadow of the building, and the position on the course was analyzed from the distribution of WBGT and UTCI in the short-term analysis of sunny day from August 2 to August 6, 2014...
April 17, 2018: International Journal of Biometeorology
https://www.readbyqxmd.com/read/29666826/dr-coffey-s-visionary-contributions-to-urological-research-in-china-and-japan
#11
EDITORIAL
Jun Shimazaki, Leland Wk Chung, Haiyen E Zhau, Tomohiko Ichikawa
No abstract text is available yet for this article.
2018: American Journal of Clinical and Experimental Urology
https://www.readbyqxmd.com/read/29666799/comparison-of-two-major-staging-systems-of-esophageal-cancer-toward-more-practical-common-scale-for-tumor-staging
#12
REVIEW
Harushi Udagawa, Masaki Ueno
The latest 8th edition of TNM Classification of Malignant Tumours by Union for International Cancer Control (UICC) and 11th edition of Japanese Classification of Esophageal Cancer by Japan Esophageal Society (JES) are the two major classifications widely accepted as tools for clinical staging of esophageal cancer. Both systems consist of three main categories, i.e., T, N, and M, but large difference exists between the two. JES system has more detailed sub-classification of T1 tumors reflecting meticulous work by Japanese investigators on superficial esophageal cancer...
February 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29666560/storage-stability-of-commonly-used-haematological-parameters-at-33-%C3%A2-c-electronic-supplementary-material-available-online-for-this-article
#13
Ashish Jain, Sanchit Jain, Neha Singh, Priyanka Aswal, Shweta Pal, Sushant Kumar Meinia, Nilotpal Chowdhury
Introduction: This study aimed to investigate the analytical bias in haematological parameters induced by storage at 33 ºC. Materials and methods: Blood from the diversion pouch of 20 blood donors were collected in K 2 EDTA vials and stored at 33 ºC. Readings from each vial were taken at 0, 4, 6, 12, 24, 48 and 72 hours after collection on the Sysmex XP-100 analyser (Sysmex Corporation, Kobe, Japan). The percent difference from the baseline readings were calculated and subjected to a Wilcoxon signed rank test at a Holm corrected significance level of 0...
June 15, 2018: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://www.readbyqxmd.com/read/29666168/-we-have-a-rich-heritage-and-we-believe-a-bright-future-how-transnational-tobacco-companies-are-using-twitter-to-oppose-policy-and-shape-their-public-identity
#14
Christina Watts, Marita Hefler, Becky Freeman
BACKGROUND: The tobacco industry has a long history of opposing tobacco control policy and promoting socially responsible business practices. With the rise of social media platforms, like Twitter, the tobacco industry is enabled to readily and easily communicate these messages. METHODS: All tweets published by the primary corporate Twitter accounts of British American Tobacco (BAT), Imperial Brands PLC (Imperial), Philip Morris International (PMI) and Japan Tobacco International (JTI) were downloaded in May 2017 and manually coded under 30 topic categories...
April 17, 2018: Tobacco Control
https://www.readbyqxmd.com/read/29666132/competencies-necessary-for-becoming-a-leader-in-the-field-of-community-medicine-a-japanese-qualitative-interview-study
#15
Mosaburo Kainuma, Makoto Kikukawa, Masaharu Nagata, Motofumi Yoshida
OBJECTIVES: To clarify competencies for inclusion in our curriculum that focuses on developing leaders in community medicine. DESIGN: Qualitative interview study. SETTING: All six regions of Japan, including urban and rural areas. PARTICIPANTS: Nineteen doctors (male: 18, female: 1) who play an important leadership role in their communities participated in semistructured interviews (mean age 48.3 years, range 34-59; mean years of clinical experience 23...
April 17, 2018: BMJ Open
https://www.readbyqxmd.com/read/29666120/true-rotational-stability-of-a-single-piece-hydrophobic-intraocular-lens
#16
Daniel Schartmüller, Sabine Schriefl, Luca Schwarzenbacher, Christina Leydolt, Rupert Menapace
BACKGROUND: To evaluate rotation and its influencing factors of an aspheric one-piece hydrophobic acrylic intraocular lens (IOL) Vivinex XY1 during 6 months after operation. METHODS: In this institutional trial, 122 eyes of 66 patients were implanted with a non-toric aspheric IOL Vivinex XY1 (Hoya Corporation, Tokyo, Japan). IOL alignment was assessed at the end of surgery, 1 hour, 1 week, 1 month and 6 months after implantation. Confounding factors such as axial length, presence of anterior fibrosis and randomised implantation in four different intended axes (0°, 45°, 90°, 135°) were evaluated...
April 17, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29665993/the-road-less-traveled-should-we-omit-prophylactic-cranial-irradiation-for-patients-with-small-cell-lung-cancer
#17
Terence T Sio, Anussara Prayongrat, Yun Zhang, Qin Lin, Ting Xu, Zhongxing Liao, Jinbo Yue
New randomized data from Japan have raised questions regarding the use of prophylactic cranial irradiation for patients with extensive-stage small-cell lung cancer but without detectable brain metastases on magnetic resonance imaging. In the present focused review, we examine the general role of prophylactic cranial irradiation in the management of small-cell lung cancer and present relevant controversies from both sides of the discussion. Future directions for clinical investigation and research are also highlighted...
March 16, 2018: Clinical Lung Cancer
https://www.readbyqxmd.com/read/29665847/tensions-in-ethics-and-policy-created-by-national-precision-medicine-programs
#18
Jusaku Minari, Kyle B Brothers, Michael Morrison
Precision medicine promises to use genomics and other data-intensive approaches to improve diagnosis and develop new treatments for major diseases, but also raises a range of ethical and governance challenges. Implementation of precision medicine in "real world" healthcare systems blurs the boundary between research and care. This has implications for the meaning and validity of consent, and increased potential for discrimination, among other challenges. Increased sharing of personal information raises concerns about privacy, commercialization, and public trust...
April 17, 2018: Human Genomics
https://www.readbyqxmd.com/read/29665820/work-impairment-osteoarthritis-and-health-related-quality-of-life-among-employees-in-japan
#19
Ken Nakata, Toshinaga Tsuji, Jeffrey Vietri, Dena H Jaffe
BACKGROUND: Osteoarthritis (OA) is one of the most common causes of health and work impairment; however, this relationship, especially in Japan, is not well characterized. This study examined work impairment and OA in Japanese workers, specifically the relationship with health-related quality of life (HRQoL) and health status. METHODS: This retrospective, cross-sectional observational study included the data of employed adults with a self-reported OA diagnosis from the 2014 Japan National Health and Wellness Survey...
April 17, 2018: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29665435/neuraminidase-inhibitor-susceptibility-and-evolutionary-analysis-of-human-influenza-b-isolates-from-three-asian-countries-during-2012-2015
#20
Akinobu Hibino, Elie Massaad, Hiroki Kondo, Reiko Saito, Takashi Odagiri, Nobuhiro Takemae, Ryota Tsunekuni, Takehiko Saito, Yadanar Kyaw, Nay Lin, Yi Yi Myint, Htay Htay Tin, Nguyen Le Khanh Hang, Le Quynh Mai, Ren Yagami, Yugo Shobugawa, Tommy Lam, Hassan Zaraket
Influenza B viruses of both the Yamagata and the Victoria lineages are implicated in a large proportion of the morbidity and mortality associated with influenza outbreaks. In this study, we characterized the full genomes of 53 influenza B viruses isolated during 2012-2015 in three Asian countries: Japan, Myanmar, and Vietnam. Analysis of the hemagglutinin (HA) genes revealed co-circulation of both the Yamagata and Victoria lineages within the same season in these countries. Our analysis revealed, that a large proportion of viruses circulating during 2013-2014 in Japan and Vietnam were mismatched to the vaccine supporting the rationale for using quadrivalent vaccines...
April 14, 2018: Infection, Genetics and Evolution
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