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https://www.readbyqxmd.com/read/28239476/prolonged-direct-hemoperfusion-using-a-polymyxin-b-immobilized-fiber-cartridge-provides-sustained-circulatory-stabilization-in-patients-with-septic-shock-a-retrospective-observational-before-after-study
#1
Kyohei Miyamoto, Yu Kawazoe, Seiya Kato
BACKGROUND: Direct hemoperfusion therapy with polymyxin B immobilized fiber cartridges (PMX-DHP) is widely used for septic shock in Japan and parts of Europe. Although this treatment is usually administered for 2 h, the optimal duration has not been established. METHODS: This retrospective study compared the effects of prolonged and conventional PMX-DHP durations (2 and 12 h, respectively) for septic shock. Between October 2013 and March 2015, 18 patients underwent conventional PMX-DHP, and between April 2015 and May 2016, 18 patients underwent prolonged PMX-DHP...
2017: Journal of Intensive Care
https://www.readbyqxmd.com/read/28239315/single-fecal-microbiota-transplantation-failed-to-change-intestinal-microbiota-and-had-limited-effectiveness-against-ulcerative-colitis-in-japanese-patients
#2
Shinta Mizuno, Kosaku Nanki, Katsuyoshi Matsuoka, Keiichiro Saigusa, Keiko Ono, Mari Arai, Shinya Sugimoto, Hiroki Kiyohara, Moeko Nakashima, Kozue Takeshita, Makoto Naganuma, Wataru Suda, Masahira Hattori, Takanori Kanai
BACKGROUND/AIMS: Recent developments in analytical techniques including next-generation sequencing have clarified the correlation between intestinal microbiota and inflammatory bowel disease. Fecal microbiota transplantation (FMT) for patients with ulcerative colitis (UC) is proposed as a potential approach to resolving their dysbiosis; however, its safety and efficacy have not been confirmed. This single-arm, open-label, non-randomized study aimed to evaluate the safety and efficacy of FMT for Japanese patients with UC as the first registered clinical trial in Japan...
January 2017: Intestinal Research
https://www.readbyqxmd.com/read/28238470/fatal-salmonellosis-in-captive-maras-dolichotis-patagonum-caused-by-salmonella-enteritidis
#3
S Nakamura, Y Yoshimura, H Hayashidani, T Iwata, S Iseda, Y Une
We report epidemic occurrences of fatal salmonellosis caused by Salmonella Enteritidis in captive maras (Dolichotis patagonum) in a zoological garden in Japan. The deaths were sudden or followed a peracute course within a few hours of the first observations of clinical abnormalities. Gross lesions included haemorrhages in the subcutis and skeletal muscles, liver, spleen, lung, heart and gastrointestinal tract. Microscopically, there were haemorrhagic and necrotizing lesions with gram-negative bacilli in the liver, spleen, small intestine and Peyer's patches...
February 23, 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/28238178/verification-of-recall-criteria-for-masses-detected-on-ultrasound-breast-cancer-screening
#4
Kanako Ban, Hiroko Tsunoda, Sakiko Suzuki, Rie Takaki, Kyouko Sasaki, Minako Nakagawa
PURPOSE: Mammography is the only modality for breast cancer screening demonstrated to reduce the mortality rate. However, ultrasonographic screening is already being widely performed as opportunistic screening in Japan. The recall criteria for masses are very important as quality controls. The purpose of this study was to verify these criteria at multiple institutions. METHODS: Screening was performed by five institutions in various regions in Japan. The total number of cases screened at all five institutions was 10,519...
February 25, 2017: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/28238011/human-rad-17-polymorphism-at-codon-546-is-associated-with-the-risk-of-colorectal-cancer
#5
Yukiko Yasuda, Akiko Sakai, Sachio Ito, Kaori Sasai, Hiromasa Yamamoto, Nagahide Matsubara, Mamoru Ouchida, Hiroshi Katayama, Kenji Shimizu
Human RAD17 acts as an activator of checkpoint signals in response to DNA damage. Here we evaluated the association of hRAD17 Leu546Arg (rs1045051), a missense single nucleotide polymorphism, with the risk of colorectal cancer (CRC) in relation to smoking and alcohol consumption habits in 212 CRC patients and 1,142 cancer-free controls in a case-control study conducted in Japan. The results showed that the hRAD17 Leu/Arg genotype compared to the Leu/Leu genotypes was significantly associated with the protective effect on CRC risk with the adjusted odds ratio (OR) of 0...
February 2017: Acta Medica Okayama
https://www.readbyqxmd.com/read/28237840/comparison-between-in-vitro-properties-of-washed-platelet-concentrates-suspended-in-m-sol-and-those-in-brs-a-both-of-which-were-prepared-with-an-automated-cell-processor
#6
Akira Iwama, Junichi Hirayama, Masayuki Nogawa, Masayuki Shiba, Masahiro Satake, Shigeru Takamoto, Kenji Tadokoro
BACKGROUND: Washed platelet concentrate (WPC) is prepared manually in general, but automated preparation is desirable to minimize variation in the WPC quality and enhance WPC production. Recently, the software was improved for an automated cell processor (ACP) to control all processes of WPC preparation. M-sol and BRS-A, which are mixtures of medical solutions, are widely used for WPC preparation with a manual method in Japan. In this study, we prepared WPC suspended in M-sol (WPC-M) or BRS-A (WPC-B) with the ACP, and compared their in vitro properties during 7-day storage...
February 9, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28237652/impact-of-epinephrine-contained-in-local-anesthetic-solution-on-serum-lactate-level-during-orthognathic-surgery
#7
Hidetaka Kuroda, Gaku Kawamura, Manabu Soya, Takayuki Kitamura, Tatsuya Ichinohe, Yoshitsugu Yamada
PURPOSE: There have been many discussions of a relation between endogenous and exogenous epinephrine and hyperlactatemia. This study aimed to identify the impact of epinephrine contained in a local anesthetic solution on serum lactate levels in patients who underwent orthognathic surgery. MATERIALS AND METHODS: This study was a retrospective record review of cases of maxillary and mandibular osteotomy at the Tokyo University Hospital (Tokyo, Japan) from January 2006 through December 2014...
February 3, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28237472/flow-stock-and-impact-assessment-of-refrigerants-in-the-japanese-household-air-conditioner-sector
#8
Mianqiang Xue, Naoya Kojima, Takashi Machimura, Akihiro Tokai
Refrigerants provide society with great benefits while have the potential to cause adverse effects on the environment and human health. The present study estimated time-dependent flows and stocks and assessed the effects of refrigerants (R-22, R-410a, and R-32) in household air conditioners in Japan. It was found that stock of R-22 and R-410a peaked at 49,147t in 2000 and 55,994t in 2017, respectively. The largest flow of R-22 and R-410a to waste phase occurred at 3417t/yr. in 2005 and 4011t/yr. in 2023, respectively...
February 22, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28237310/sampling-design-and-required-sample-size-for-evaluating-contamination-levels-of-137-cs-in-japanese-fir-needles-in-a-mixed-deciduous-forest-stand-in-fukushima-japan
#9
Yurika Oba, Toshihiro Yamada
We estimated the sample size (the number of samples) required to evaluate the concentration of radiocesium ((137)Cs) in Japanese fir (Abies firma Sieb. & Zucc.), 5 years after the outbreak of the Fukushima Daiichi Nuclear Power Plant accident. We investigated the spatial structure of the contamination levels in this species growing in a mixed deciduous broadleaf and evergreen coniferous forest stand. We sampled 40 saplings with a tree height of 150 cm-250 cm in a Fukushima forest community. The results showed that: (1) there was no correlation between the (137)Cs concentration in needles and soil, and (2) the difference in the spatial distribution pattern of (137)Cs concentration between needles and soil suggest that the contribution of root uptake to (137)Cs in new needles of this species may be minor in the 5 years after the radionuclides were released into the atmosphere...
February 22, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28237291/screening-test-for-radioactivity-of-self-consumption-products-in-fukushima-after-the-fukushima-dai-ichi-npp-accident-in-japan
#10
Takahiro Yamada, Mihoko Kikuchi, Daisuke Yagihashi, Shinya Yamakawa, Hidetake Ishizu, Takuya Shiina
A food inspection service system for home grown products or wild plants collected by individual consumers for self-consumption was implemented in Fukushima in Nov. 2012. About 500 NaI(Tl) scintillation spectrometers were distributed to 300 or more temporary testing laboratories which were set up in public halls or meeting places of the municipalities. The screening method for radiocaesium was adapted to the present inspection service system. The performance of the equipment under field conditions was evaluated using sampled data obtained by temporary testing laboratories...
February 23, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28237238/epidemiological-evaluation-of-cats-rescued-at-a-secondary-emergency-animal-shelter-in-miharu-fukushima-after-the-great-east-japan-earthquakes
#11
Aki Tanaka, Beatriz Martinez-Lopez, Philip Kass
The aims of this research were to report characteristics of rescued cats at a secondary emergency animal shelter in Fukushima prefecture, Japan, and evaluate how adoptability, stress level, upper respiratory infection (URI) syndrome incidence, and URI pathogen prevalence were associated with the cat's shelter intake source and shelter characteristics. All cats admitted to the Miharu shelter, Fukushima Prefecture from 2012 to 2014 were included in the study. The results demonstrate that in situ corticosteroid and antibiotic use were associated with cats subsequently developing upper respiratory infections (URI)...
March 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28236981/phase-i-ii-study-of-tecemotide-as-immunotherapy-in-japanese-patients-with-unresectable-stage-iii-non-small-cell-lung-cancer
#12
Nobuyuki Katakami, Toyoaki Hida, Hiroshi Nokihara, Fumio Imamura, Hiroshi Sakai, Shinji Atagi, Makoto Nishio, Tatsuhiko Kashii, Miyako Satouchi, Christoph Helwig, Morihiro Watanabe, Tomohide Tamura
OBJECTIVES: Unresectable stage III NSCLC (non-small cell lung cancer) confers a poor prognosis and interest is growing in the use of immunotherapy to improve outcomes for patients with this disease. We investigated the safety and efficacy of maintenance tecemotide, a mucin 1 (MUC1)-specific agent that induces T-cell responses to MUC1, versus placebo in Japanese patients with stage III unresectable NSCLC and no disease progression after primary chemoradiotherapy. MATERIALS AND METHODS: Patients aged ≥20 years with unresectable stage III NSCLC, stable disease or clinical response after primary chemoradiotherapy and performance status ≤1, were recruited across 25 centers in Japan...
March 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28236631/causes-of-intrauterine-fetal-death-are-changing-in-recent-years
#13
Hiroko Takita, Junichi Hasegawa, Masamitsu Nakamura, Tatsuya Arakaki, Tomohiro Oba, Ryu Matsuoka, Akihiko Sekizawa
OBJECTIVE: To investigate, how causes of intrauterine fetal death (IUFD) have changed in recent years with the advancement of prenatal diagnosis at a single perinatal center in Japan. METHODS: Medical records were retrospectively reviewed for all cases of IUFDs that occurred between 2001 and 2014. The most commonly associated causes of fetal deaths were compared between 2001-2007 and 2008-2014. RESULTS: The number of IUFD after 20 weeks' gestation/all deliveries in our center was 38/6878 cases (0...
February 25, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28236606/physical-function-differences-between-the-stages-from-normal-cognition-to-moderate-alzheimer-disease
#14
Chisato Fujisawa, Hiroyuki Umegaki, Kazushi Okamoto, Hirotaka Nakashima, Masafumi Kuzuya, Kenji Toba, Takashi Sakurai
OBJECTIVES: We investigated the differences in the physical function test results across stages from normal cognition (NC) to moderate Alzheimer disease (AD) and how risk factors of physical function decline are correlated with the physical function test results. DESIGN: A cross-sectional study of outpatients at the Memory Disorder Outpatient Center of Japan's National Center of Geriatrics and Gerontology. PARTICIPANTS: We enrolled 882 individuals aged ≥65 diagnosed with NC (n = 210), amnestic mild cognitive impairment (aMCI; n = 273), mild AD (n = 181) or moderate AD (n = 197)...
February 21, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28236484/characterization-and-source-profiling-of-volatile-organic-compounds-in-indoor-air-of-private-residences-in-selangor-state-malaysia
#15
Nobumitsu Sakai, Shuta Yamamoto, Yasuto Matsui, Md Firoz Khan, Mohd Talib Latif, Mustafa Ali Mohd, Minoru Yoneda
Volatile Organic Compounds (VOCs) in indoor air were investigated at 39 private residences in Selangor State, Malaysia to characterize the indoor air quality and to identify pollution sources. Twenty-two VOCs including isomers (14 aldehydes, 5 aromatic hydrocarbons, acetone, trichloroethylene and tetrachloroethylene) were collected by 2 passive samplers for 24h and quantitated using high performance liquid chromatography and gas chromatography mass spectrometry. Source profiling based on benzene/toluene ratio as well as statistical analysis (cluster analysis, bivariate correlation analysis and principal component analysis) was performed to identify pollution sources of the detected VOCs...
February 21, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28236464/future-life-expectancy-in-35-industrialised-countries-projections-with-a-bayesian-model-ensemble
#16
Vasilis Kontis, James E Bennett, Colin D Mathers, Guangquan Li, Kyle Foreman, Majid Ezzati
BACKGROUND: Projections of future mortality and life expectancy are needed to plan for health and social services and pensions. Our aim was to forecast national age-specific mortality and life expectancy using an approach that takes into account the uncertainty related to the choice of forecasting model. METHODS: We developed an ensemble of 21 forecasting models, all of which probabilistically contributed towards the final projections. We applied this approach to project age-specific mortality to 2030 in 35 industrialised countries with high-quality vital statistics data...
February 21, 2017: Lancet
https://www.readbyqxmd.com/read/28236327/analytical-evaluation-of-the-adams-%C3%A2-a1c-ha8180t-analyzer-for-the-measurement-of-hba1c
#17
Eloísa Urrechaga
BACKGROUND: The ADAMS(™) A1c HA-8180T (ARKRAY, Inc., Kyoto, Japan) is a high pressure liquid chromatography system designed for separation and quantitation of HbA1c, while detecting hemoglobin (Hb) variants and HbA2 , with an analysis time of just 3.5 min. The aim was to evaluate the analytical performance of this analyzer for routine HbA1c quantitation. METHODS: Trueness, imprecision, carry over, linearity, the effect of anemia and correlation with ADAMS(™) A1c HA-8180V (in Variant mode) were assessed according to guidelines of the Clinical and Laboratory Standards Institute (CLSI) and manufacturer...
February 25, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28236250/group-b-streptococcal-disease-in-infants-in-the-first-year-of-life-a-nationwide-surveillance-study-in-japan-2011-2015
#18
Kousaku Matsubara, Kiyoshi Hoshina, Masatoshi Kondo, Isao Miyairi, Yoshiya Yukitake, Yusuke Ito, Kisei Minami, Ryuichi Genkawa
PURPOSE: This study aimed to describe the epidemiology of childhood group B streptococcus (GBS) disease including late late-onset disease (LLOD) and to clinically characterize recurrent cases and twin-sibling cases in Japan. METHODS: We collected information on infants (<1 year of age) with invasive GBS disease and institutional information about births and transfers through a nationwide questionnaire between 2011 and 2015. RESULTS: We identified 133 infants with early-onset disease (EOD), 274 late-onset disease (LOD), and 38 LLOD from 149 institutes...
February 25, 2017: Infection
https://www.readbyqxmd.com/read/28236116/clinical-pharmacokinetic-and-pharmacodynamic-profile-of-lenvatinib-an-orally-active-small-molecule-multitargeted-tyrosine-kinase-inhibitor
#19
Ziad Hussein, Hitoshi Mizuo, Seiichi Hayato, Masayuki Namiki, Robert Shumaker
Lenvatinib is a multikinase inhibitor that targets vascular endothelial growth factor (VEGF) receptors 1-3, fibroblast growth factor receptors 1-4, platelet-derived growth factor receptor-alpha, and RET and KIT proto-oncogenes. Lenvatinib is approved for the treatment of radioiodine-refractory differentiated thyroid cancer in the United States (US), European Union (EU), Canada, Japan, and Switzerland. It is also approved in combination with everolimus for the treatment of advanced renal cell carcinoma following ≥1 VEGF-targeted treatment in the US and EU...
February 24, 2017: European Journal of Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/28235967/social-disadvantages-associated-with-myasthenia-gravis-and-its-treatment-a-multicentre-cross-sectional-study
#20
Yuriko Nagane, Hiroyuki Murai, Tomihiro Imai, Daisuke Yamamoto, Emiko Tsuda, Naoya Minami, Yasushi Suzuki, Tetsuya Kanai, Akiyuki Uzawa, Naoki Kawaguchi, Masayuki Masuda, Shingo Konno, Hidekazu Suzuki, Masashi Aoki, Kimiaki Utsugisawa
OBJECTIVES: To clarify the social disadvantages associated with myasthenia gravis (MG) and examine associations with its disease and treatment. DESIGN: Cross-sectional study. SETTING AND PARTICIPANTS: We evaluated 917 consecutive cases of established MG seen at 13 neurological centres in Japan over a short duration. OUTCOME MEASURES: All patients completed a questionnaire on social disadvantages resulting from MG and its treatment and a 15-item MG-specific quality of life scale at study entry...
February 23, 2017: BMJ Open
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