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https://www.readbyqxmd.com/read/28941361/hepatitis-c-virus-testing-for-case-identification-in-persons-born-during-1945-1965-results-from-three-randomized-controlled-trials
#1
Anthony K Yartel, David B Rein, Kimberly Ann Brown, Katherine Krauskopf, Omar I Massoud, Cynthia Jordan, Natalie Kil, Alex D Federman, David R Nerenz, Joanne E Brady, Danielle L Kruger, Bryce D Smith
CDC and U.S. Preventive Services Task Force recommend one-time hepatitis C virus (HCV) testing for persons born during 1945-1965 (birth cohort). However, few studies estimate the effect of birth cohort (BC) testing implementation on HCV diagnoses in primary care settings. We aimed to determine the probability of identifying HCV infections in primary care using targeted BC testing compared with usual care at three academic medical centers. From December 2012 to March 2014, each center compared one of three distinct interventions to usual care using an independently-designed randomized controlled trial...
September 23, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28938735/the-age-of-fathers-in-the-usa-is-rising-an-analysis-of-168-867-480-births-from-1972-to-2015
#2
Yash S Khandwala, Chiyuan A Zhang, Ying Lu, Michael L Eisenberg
STUDY QUESTION: How has the mean paternal age in the USA changed over the past 4 decades? SUMMARY ANSWER: The age at which men are fathering children in the USA has been increasing over time, although it varies by race, geographic region and paternal education level. WHAT IS KNOWN ALREADY: While the rise in mean maternal age and its implications for fertility, birth outcomes and public health have been well documented, little is known about paternal characteristics of births within the USA...
October 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28937995/enzootic-mosquito-vector-species-at-equine-encephalitis-transmission-foci-in-the-rep%C3%A3%C2%BAblica-de-panam%C3%A3
#3
Rolando Torres, Rafael Samudio, Jean-Paul Carrera, Josue Young, Ricardo Márquez, Lisbeth Hurtado, Scott Weaver, Luis Fernando Chaves, Robert Tesh, Lorenzo Cáceres
The identification of mosquito vector species present at arboviral enzootic transmission foci is important to understand transmission eco-epidemiology and to propose and implement prevention and control strategies that reduce vector-borne equine encephalitis transmission. The goal of this study was to identify mosquito species potentially involved in the transmission of enzootic equine encephalitis, in relation to their abundance and diversity at three endemic regions in the República de Panamá. We sampled adult mosquitoes during the dry and rainy season of Panamá...
2017: PloS One
https://www.readbyqxmd.com/read/28937792/timeliness-of-measles-laboratory-reporting-and-factors-associated-with-delays-zhejiang-province-china-2009-2015
#4
Hanqing He, Rui Yan, Chunhong Fan, Fangyuan Jing, Ye Ding
In 2006, China targeted measles for elimination by 2012, but the goal was not achieved. In line with this goal, the timeliness of measles laboratory reporting should be evaluated to improve efficiency in implementing control measures. Laboratory-confirmed suspected measles cases reported to the measles surveillance system in Zhejiang Province, China, from 2009 to 2015 were collected. Three reporting periods were defined: transport duration (period from serum collected to serum received in lab), analysis duration (period from serum received to the result being reported), and total reporting duration...
September 22, 2017: Health Security
https://www.readbyqxmd.com/read/28937368/human-immunodeficiency-virus-associated-cystic-lymphoid-hyperplasia-an-immunohistochemical-description
#5
Shabnum Meer, Shailen Dulabh
BACKGROUND: Cystic lymphoid hyperplasia (CLH) describes benign salivary lymphoepithelial cysts with a strong link to human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS). The pathogenesis is related to ductal dilatation of entrapped salivary elements due to intranodal HIV-associated atypical lymphoid hyperplasia. Very little is known about the immunophenotypic profile of this entity. AIM: This study aims to describe the immunopathological features of a series of CLH cases in HIV-positive patients to clarify the etiopathogenesis...
July 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28935999/integrating-a-biorepository-into-the-national-amyotrophic-lateral-sclerosis-registry
#6
D Kevin Horton, Wendy Kaye, Laurie Wagner
As part of our continuing effort to highlight innovative approaches to improving the health and environment of communities, the Journal is pleased to publish a bimonthly column from the Agency for Toxic Substances and Disease Registry (ATSDR). ATSDR is a federal public health agency of the U.S. Department of Health and Human Services (HHS) and shares a common office of the Director with the National Center for Environmental Health (NCEH) at the Centers for Disease Control and Prevention (CDC). ATSDR serves the public by using the best science, taking responsive public health actions, and providing trusted health information to prevent harmful exposures and diseases related to toxic substances...
November 2016: Journal of Environmental Health
https://www.readbyqxmd.com/read/28935569/constitutive-cd40-signaling-in-dendritic-cells-limits-atherosclerosis-by-provoking-inflammatory-bowel-disease-and-ensuing-cholesterol-malabsorption
#7
Pascal Kusters, Tom Seijkens, Christina Bürger, Bart Legein, Holger Winkels, Marion Gijbels, Christian Barthels, Remy Bennett, Linda Beckers, Dorothee Atzler, Erik Biessen, Thomas Brocker, Christian Weber, Norbert Gerdes, Esther Lutgens
The co-stimulatory molecule CD40 is a major driver of atherosclerosis. It is expressed on a wide variety of cell types including mature dendritic cells (DCs) and is required for optimal T cell activation and expansion. It remains undetermined if and how CD40 on DCs impacts the pathogenesis of atherosclerosis. Here we examined the effects of constitutively active CD40 in DCs on atherosclerosis, using low-density lipoprotein-deficient (Ldlr(-/-)) bone-marrow chimeras that express a transgene containing an engineered latent membrane protein 1 (LMP)/CD40 fusion protein conferring constitutive CD40 signaling under control of the DC-specific CD11c promoter (DC-LMP1/CD40)...
September 18, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28934724/integrating-health-into-local-climate-response-lessons-from-the-u-s-cdc-climate-ready-states-and-cities-initiative
#8
Mary C Sheehan, Mary A Fox, Charlotte Kaye, Beth Resnick
Public health has potential to serve as a frame to convey the urgency of behavior change needed to adapt to a changing climate and reduce greenhouse gas emissions. Local governments form the backbone of climate-related public health preparedness. Yet local health agencies are often inadequately prepared and poorly integrated into climate change assessments and plans. We reviewed the climate health profiles of 16 states and two cities participating in the U.S. Centers for Disease Control and Prevention (CDC)'s Climate-Ready States and Cities Initiative (CRSCI) that aims to build local capacity to assess and respond to the health impacts of climate change...
September 20, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28934263/temporal-dynamics-and-leishmania-infantum-infection-prevalence-of-phlebotomus-perniciosus-diptera-phlebotominae-in-highly-endemic-areas-of-visceral-leishmaniasis-in-tunisia
#9
Meriem Benabid, Jamila Ghrab, Adel Rhim, Rania Ben-Romdhane, Karim Aoun, Aïda Bouratbine
Phlebotomus perniciosus is one of the major vectors of Leishmania infantum in the Mediterranean basin. The aim of this work was (i) to provide information about abundance and temporal dynamics of this Larroussius species in a hot spot area of visceral leishmaniasis in Tunisia, (ii) to detect L. infantum DNA in wild caught female sandflies and (iii) to measure Phlebotomus perniciosus infection rate throughout the active season. Sandflies were collected monthly during one year using CDC miniature light-traps in house and in animal shelters...
2017: PloS One
https://www.readbyqxmd.com/read/28934187/respiratory-and-ocular-symptoms-among-employees-of-an-indoor-waterpark-resort-ohio-2016
#10
Sophia K Chiu, Nancy C Burton, Kevin H Dunn, Marie A de Perio
In July 2015, a municipal health department in Ohio received complaints of respiratory and ocular symptoms from patrons of an indoor waterpark resort. In response, the health department conducted an online survey in August 2015 through which 19 (68%) patron and employee respondents reported eye burning, nose irritation, difficulty breathing, and vomiting. On August 11, 2015, the health department requested a health hazard evaluation by CDC's National Institute for Occupational Safety and Health to characterize the prevalence of symptoms among employees and determine the etiology of work-related symptoms...
September 22, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28934185/hiv-care-outcomes-among-men-who-have-sex-with-men-with-diagnosed-hiv-infection-united-states-2015
#11
Sonia Singh, Andrew Mitsch, Baohua Wu
Gay, bisexual, and other men who have sex with men (collectively referred to as MSM) represent approximately 2% of the U.S. population (1), yet in 2015, MSM accounted for 70% of all diagnoses of human immunodeficiency virus (HIV) infection, including 3% who also were persons who inject drugs (2). During 2008-2014, incidence of HIV infection decreased for groups in all transmission categories except MSM (3). Testing, linkage to and retention in care, and viral suppression are important in reducing HIV transmission...
September 22, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28934182/hurricane-season-public-health-preparedness-response-and-recovery-guidance-for-health-care-providers-response-and-recovery-workers-and-affected-communities-cdc-2017
#12
(no author information available yet)
CDC and the Agency for Toxic Substances and Disease Registry (ATSDR) have guidance and technical materials available in both English and Spanish to help communities prepare for hurricanes and floods (Table 1). To help protect the health and safety of the public, responders, and clean-up workers during response and recovery operations from hurricanes and floods, CDC and ATSDR have developed public health guidance and other resources; many are available in both English and Spanish (Table 2).
September 22, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28934181/notes-from-the-field-increase-in-reported-hepatitis-a-infections-among-men-who-have-sex-with-men-new-york-city-january-august-2017
#13
Julia Latash, Marie Dorsinville, Paula Del Rosso, Mike Antwi, Vasudha Reddy, HaeNa Waechter, Jacqueline Lawler, Heather Boss, Philip Kurpiel, P Bryon Backenson, Charles Gonzalez, Shannon Rowe, Tasha Poissant, Yulin Lin, Guo-Liang Xia, Sharon Balter
Since 2011, the New York City (NYC) Department of Health and Mental Hygiene (DOHMH) has typically been notified of three or fewer cases of hepatitis A virus (HAV) infection each year among men who have sex with men (MSM) who reported no travel to countries where HAV is endemic. This year, DOHMH noted an increase in HAV infections among MSM with onsets in January-March 2017, and notified other public health jurisdictions via Epi-X, CDC's communication exchange network. As a result, 51 patients with HAV infection involving MSM were linked to the increase in NYC...
September 22, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28934178/update-to-cdc-s-u-s-medical-eligibility-criteria-for-contraceptive-use-2016-revised-recommendations-for-the-use-of-hormonal-contraception-among-women-at-high-risk-for-hiv-infection
#14
Naomi K Tepper, Jamie W Krashin, Kathryn M Curtis, Shanna Cox, Maura K Whiteman
CDC's U.S. Medical Eligibility Criteria for Contraceptive Use (U.S. MEC) (first published in 2010 and updated in 2016) provides evidence-based guidance for the safe use of contraceptive methods among U.S. women with certain characteristics or medical conditions (1), and is adapted from global guidance from the World Health Organization (WHO) and kept up to date based on continual review of published literature (2).* CDC recently evaluated the evidence and the updated WHO guidance on the risk for human immunodeficiency virus (HIV) acquisition among women using hormonal contraception...
September 22, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28932964/treatment-strategies-for-the-opioid-dependent-patient
#15
REVIEW
Shweta Teckchandani, Meredith Barad
PURPOSE OF REVIEW: This review is intended to help the headache physician think through and plan for management issues concerning the use of opioids. We ask the headache physician to consider if there are instances where prescribing or continuing prescriptions of opiates is plausible, and if so, how can the physician proceed as safely as possible. Our goal is to start a conversation regarding the inevitable encounter with a patient on opiates or requesting opiates. RECENT FINDINGS: The use of opiates in our society has reached a crisis in staggering death and addiction rates...
September 20, 2017: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/28932690/a-case-of-metastatic-collecting-duct-carcinoma-whose-massive-skull-bone-metastasis-was-prominently-reossified-by-gemcitabine-plus-cisplatin-chemotherapy-combined-with-zoledronic-acid
#16
Makoto Kawaguchi, Keiichi Ito, Hideyuki Shimazaki, Tomohiko Asano
The present case underwent right laparoscopic radical nephrectomy for collecting duct carcinoma (CDC). Recurrence occurred in the lung and the bone (skull and lumber vertebra) in 2011. Gemcitabine plus cisplatin (GC) chemotherapy and monthly zoledronic acid (ZA) was then started. The massive skull bone metastases were prominently reossified after several courses of the therapy. The patient received 16 courses of GC chemotherapy and monthly ZA, and pulmonary metastases and reossified skull bone metastases were stable for 23 months...
November 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28932611/chronic-pelvic-pain-and-infertility-resulting-from-unrecognized-retained-laminaria
#17
Wesley Nilsson, Sasha Mikhael, Jennifer Kaplan
BACKGROUND: In 2013, the abortion rate in the United States was found to be 200 abortions per 1,000 live births. Of these, the CDC estimates that nearly 49% were performed using unsafe measures. Even when these procedures are safely performed, patients are at risk for immediate or delayed complications. In second-trimester terminations, mechanical dilation with an osmotic dilator is common to allow for delivery of the fetus. The Japanese seaweed Laminaria japonica is used to achieve this purpose...
2017: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28929591/cobalt-catalyzed-cross-dehydrogenative-c-sp2-c-sp3-coupling-of-oxazole-thiazole-with-ether-or-cycloalkane
#18
Xiaojiao Wang, Bowen Lei, Lifang Ma, Lisi Zhu, Xinyue Zhang, Hao Zuo, Dailin Zhuang, Ziyuan Li
Direct C5-alkylation of oxazole/thiazole with ether or cycloalkane has been achieved through a cobalt-catalyzed cross-dehydrogenative couling (CDC) process in moderate to good yields. This transformation represents the first C(sp2)-C(sp3) cross-coupling at the C5-position of azole via double C-H bond cleavages. Various functional groups on oxazole/thiazole substrates, as well as water and air, are well-tolerated with this concise and practical protocol, constituting straightforward access to heterocycles with great medicinal significance...
September 19, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28928834/cd55-and-cd59-expression-protects-her2-overexpressing-breast-cancer-cells-from-trastuzumab-induced-complement-dependent-cytotoxicity
#19
Yu Wang, Ya-Jun Yang, Zhu Wang, Juan Liao, Mei Liu, Xiao-Rong Zhong, Hong Zheng, Yan-Ping Wang
A large proportion (40-60%) of patients with human epidermal growth factor receptor 2 (HER2)-overexpressing breast cancer do not benefit from trastuzumab treatment, potentially due to the lack of complement-dependent cytotoxicity (CDC) activation. In the present study, the effect of complement decay-accelerating factor (CD55) and CD59 glycoprotein precursor (CD59) expression on trastuzumab-induced CDC in HER2-positive breast cancer cell lines was investigated. The CD55 and CD59-overexpressing and HER2-positive cell lines SK-BR-3 and BT474 were selected for subsequent experiments...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28926705/a-low-temperature-transition-metal-free-cross-dehydrogenative-coupling-protocol-for-the-synthesis-of-3-3-disubstituted-oxindoles
#20
James R Donald, Richard John Kenneth Taylor, Wade F Petersen
A new low-temperature procedure for the synthesis of 3,3-disubstituted 2-oxindoles via cross dehydrogenative coupling (CDC) is reported. The use of a strong, non-reversible base in these reactions has been found to effect a dramatic drop in reaction temperature (to room temperature) relative to the current state-of-the-art (>100 °C). When employing iodine as an 'oxidant', new evidence suggests that this transformation may occur via a transiently stable iodinated intermediate rather than by direct single-electron oxidation...
September 19, 2017: Journal of Organic Chemistry
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