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https://www.readbyqxmd.com/read/28239658/loss-of-immune-homeostasis-dictates-shiv-rebound-after-stem-cell-transplantation
#1
Christopher W Peterson, Clarisse Benne, Patricia Polacino, Jasbir Kaur, Cristina E McAllister, Abdelali Filali-Mouhim, Willi Obenza, Tiffany A Pecor, Meei-Li Huang, Audrey Baldessari, Robert D Murnane, Ann E Woolfrey, Keith R Jerome, Shiu-Lok Hu, Nichole R Klatt, Stephen DeRosa, Rafick P Sékaly, Hans-Peter Kiem
The conditioning regimen used as part of the Berlin patient's hematopoietic cell transplant likely contributed to his eradication of HIV infection. We studied the impact of conditioning in simian-human immunodeficiency virus-infected (SHIV-infected) macaques suppressed by combination antiretroviral therapy (cART). The conditioning regimen resulted in a dramatic, but incomplete depletion of CD4(+) and CD8(+) T cells and CD20(+) B cells, increased T cell activation and exhaustion, and a significant loss of SHIV-specific Abs...
February 23, 2017: JCI Insight
https://www.readbyqxmd.com/read/28239498/cognitive-pragmatic-rehabilitation-program-in-schizophrenia-a-single-case-fmri-study
#2
Ilaria Gabbatore, Francesca M Bosco, Elisabetta Geda, Luigi Gastaldo, Sergio Duca, Tommaso Costa, Bruno G Bara, Katiuscia Sacco
Introduction. The present study was intended to evaluate the effects of a rehabilitative training, the Cognitive Pragmatic Treatment (CPT), aimed at improving communicative-pragmatic abilities and the related cognitive components, on the cerebral modifications of a single case patient diagnosed with schizophrenia. Methods. The patient underwent two functional magnetic resonance imaging (fMRI) sessions, before and after the treatment. In order to assess brain changes, we calculated the Amplitude of Low Frequency Fluctuation (ALFF) index of the resting-state fMRI signal, which is interpreted as reflecting the intensity of the spontaneous regional activity of the brain...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/28239141/chronic-myeloid-leukemia-associated-hypercalcemia-a-case-report-and-literature-review
#3
David Toro-Tobón, Sarimar Agosto, Sara Ahmadi, Maureen Koops, Jan M Bruder
BACKGROUND Hypercalcemia associated with chronic myeloid leukemia (CML) is an ominous sign. Although rare, several cases have been reported and multiple pathophysiologic mechanisms have been independently proposed. We present a patient case and a literature review of the clinical presentation and mechanisms of CML-associated hypercalcemia. CASE REPORT A 58-year-old male with a past medical history of CML diagnosed six years earlier, presented to the emergency department with one week of acute confusion, disorientation, polyuria, and polydipsia...
February 27, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28238975/written-forms-of-signed-languages-a-route-to-literacy-for-deaf-learners
#4
Connie Mayer
While there have been attempts to develop written systems for signed languages, none have been widely used or adopted. In his article in an American Annals of the Deaf special issue that also includes the present article, Grushkin makes a case not only for why, but how efforts should be renewed to develop a written signed language, suggesting that increased written-English competence will be a consequence of increased competence in written and signed American Sign Language, with literacy-related skills transferring across languages...
2017: American Annals of the Deaf
https://www.readbyqxmd.com/read/28238973/writing-signed-languages-what-for-what-form-a-response
#5
Donald F Moores
In his article in an American Annals of the Deaf special issue that also includes the present article, Grushkin divides his discussion of a written sign system into three basic parts. The first presents arguments against the development of a written form of American Sign Language; the second provides a rationale for a written form of ASL; the third advances opinions of the form such a system might take. The arguments in the first part are weak and reflect the same bias that historically has been shown against ASL itself...
2017: American Annals of the Deaf
https://www.readbyqxmd.com/read/28238972/-thinking-for-writing-a-prolegomenon-on-writing-signed-languages
#6
Russell S Rosen, Maria C Hartman, Ye Wang
In his article in this American Annals of the Deaf special issue that also includes the present article, Grushkin argues that the writing difficulties of many deaf and hard of hearing children result primarily from the orthographic nature of the writing system; he proposes a new system based on features found in signed languages. In response, the present authors review the literature on D/HH children's writing difficulties, outline the main percepts of and assumptions about writing signed languages, discuss "thinking-for-writing" as a process in developing writing skills, offer research designs to test the effectiveness of writing signed language systems, and provide strategies for adopting "thinking-for-writing" in education...
2017: American Annals of the Deaf
https://www.readbyqxmd.com/read/28238826/environmental-factors-and-teenagers-personalities-the-role-of-personal-and-familial-socio-cultural-level
#7
Elisa Menardo, Giulia Balboni, Roberto Cubelli
: Environmental (e.g., socio-cultural context), individual (e.g., genetic makeup), and interpersonal (e.g., caregiver-children relationships) factors can play a crucial role in shaping the development of the teenagers' personality. In this study, we focused on the Socio-Cultural Level that designates the set of preferences, knowledge and behaviors that characterize an individual's way of life and depend on his or her cultural, social and economic resources. We studied the relationship between Socio-Cultural Level (personal, maternal and paternal) and Big Five personality traits of 191 teenagers living in the same geographical area...
February 23, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28238785/zn-2-dependent-autocatalytic-activity-of-the-bordetella-pertussis-cyaa-hemolysin
#8
Veerada Raksanoh, Lalida Shank, Panchika Prangkio, Mattayaus Yentongchai, Somsri Sakdee, Chompounoot Imtong, Chanan Angsuthanasombat
Proteolytic degradation of the ∼100-kDa isolated RTX (Repeat-in-ToXin) subdomain (CyaA-RTX) of the Bordetella pertussis CyaA-hemolysin (CyaA-Hly) was evidently detected upon solely-prolonged incubation. Here, a truncated CyaA-Hly fragment (CyaA-HP/BI) containing hydrophobic and acylation regions connected with the first RTX block (BI1015-1088) was constructed as a putative precursor for investigating its potential autocatalysis. The 70-kDa His-tagged CyaA-HP/BI fragment which was over-expressed in Escherichia coli as insoluble aggregate was entirely solubilized with 4 M urea...
February 23, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28238766/a-split-brain-case-study-on-the-hemispheric-lateralization-of-inhibitory-control
#9
Nicholas D'Alberto, Margaret Funnell, Alexandra Potter, Hugh Garavan
Understanding the neurobiological mechanisms underlying inhibitory control is crucial given its role in various disease states and substance abuse/misuse. Neuroimaging research examining inhibitory control has yielded conflicting results on the relative importance of the left and right hemisphere during successful inhibition of a motor response. In the current study, a split-brain patient was examined in order to assess the independent inhibitory capabilities of each hemisphere. The patient's right hemisphere exhibited superior inhibitory ability compared to his left hemisphere on three inhibitory control tasks...
February 23, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28237945/rare-association-of-congenital-penile-urethrocutaneous-fistula-with-y-type-urethral-duplication
#10
Ashok Kumar Gupta, Manoj Kumar, Kawaljit Singh, Ashok Kumar Sokhal
A 24-year-old man presented with symptoms of difficulty in passage of urine, mixed with gas and stool from penoscrotal junction since birth. He had a history of surgery (posterior sagittal anorectoplasty) for imperforate anus in first week of his life. On physical examination, external meatus was adequate with small 5×5 mm fistulous opening noted at penoscrotal junction with normal anal tone and opening. On evaluation with retrograde urethrography, voiding cystourethrogram, cystoscopy and barium enema, he was found to have penile urethrocutaneous fistula of 0...
February 24, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28237826/treatment-considerations-for-depression-research-in-older-married-couples-a-dyadic-case-study
#11
Sarah T Stahl, Juleen Rodakowski, Ariel G Gildengers, Charles F Reynolds, Jennifer Q Morse, Kevin Rico, Meryl A Butters
OBJECTIVE: Critical gaps remain in understanding optimal approaches to intervening with older couples. The focus of this report is to describe the pros and cons of incorporating spousal dyads into depression-prevention research. METHODS: In an intervention development study, the authors administered problem-solving therapy (PST) dyadically to participants with mild cognitive impairment (MCI) and their caregivers. Dyads worked with the same interventionist in the same therapy session...
January 4, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28237734/respective-role-of-surface-electrocardiogram-and-his-bundle-recordings-to-assess-the-risk-of-atrioventricular-block-after-transcatheter-aortic-valve-replacement
#12
N Badenco, C Chong-Nguyen, C Maupain, C Himbert, G Duthoit, X Waintraub, T Chastre, E Gandjbakhch, F Hidden-Lucet, P Le Prince, J-P Collet, R Frank
BACKGROUND: Atrioventricular block (AVB) is common after transcatheter aortic valve replacement (TAVR) and permanent pacemaker (PPM) implantation is needed in up to 30% of patients. Main predictors of long term AVB are electrocardiographic. The purpose of this study is to assess the prognostic value of serial HV intervals measured before and after TAVR to shorten the timing of PPM implantation. METHODS: His bundle recordings were performed before (HV1), immediately after TAVR (HV2) and at day 2 for Edwards Sapien (ES) and 5 for Medtronic CoreValve (CV) (HV3)...
February 10, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28237602/effects-of-intramuscular-injections-of-folic-acid-vitamin-b12-or-both-on-lactational-performance-and-energy-status-of-multiparous-dairy-cows
#13
M Duplessis, H Lapierre, D Pellerin, J-P Laforest, C L Girard
The purpose of this experiment was to gain understanding on changes in energy partitioning when folic acid and vitamin B12 supplements, alone or combined, were given by weekly intramuscular injections from 3 wk before the expected calving date until 7 wk postpartum. Twenty-four multiparous cows were assigned to 6 blocks of 4 cows each according to previous 305-d lactation yield to either 0 or 320 mg of folic acid and 0 or 10 mg of vitamin B12 in a 2 × 2 factorial arrangement. Plasma concentration of folates was increased by folic acid supplement, and this increase was greater with the combined supplement...
February 22, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28236807/pediatric-tuberculosis-human-immunodeficiency-virus-co-infection-in-the-united-kingdom-highlights-the-need-for-better-therapy-monitoring-tools-a-case-report
#14
Dimitrios Evangelopoulos, Elizabeth Whittaker, Isobella Honeyborne, Timothy D McHugh, Nigel Klein, Delane Shingadia
BACKGROUND: Tuberculosis is an infection that requires at least 6 months of chemotherapy in order to clear the bacteria from the patient's lungs. Usually, therapeutic monitoring is dependent on smear microscopy where a decline in acid-fast bacilli is observed. However, this might not be indicative of the actual decline of bacterial load and thus other tools such as culture and molecular assays are required for patient management. CASE PRESENTATION: Here, we report the case of a 12-year-old Black African boy co-infected with tuberculosis and human immunodeficiency virus who remained smear culture positive and liquid culture negative for a prolonged period of time following chemotherapy...
February 26, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28236615/effects-of-music-therapy-on-endothelial-function-in-patients-with-coronary-artery-disease-participating-in-aerobic-exercise-therapy
#15
Marina Deljanin Ilic, Radmila F Pavlovic, Gordana Kocic, Dejan Simonovic, Gordana Lazarevic
Context • Pleasant music that evokes a positive emotional response may activate brain pathways of the insular cortex, central nucleus of the amygdala, and lateral hypothalamus, which are involved in the integration of emotional and ambient sensory input, with corresponding autonomic responses. Exercise training can improve endothelium-dependent vasodilatation, both in epicardial coronary vessels and in resistance vessels, for patients with coronary heart disease. Objective • The aim of the present study was to evaluate the effects on endothelial function when patients with stable coronary artery disease (CAD) listened to their favorite music...
February 27, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28236609/accuracy-of-teledentistry-for-diagnosing-dental-pathology-using-direct-examination-as-a-gold-standard-results-of-the-tel-e-dent-study-of-older-adults-living-in-nursing-homes
#16
Alain Queyroux, Bernard Saricassapian, Daniel Herzog, Karin Müller, Isabelle Herafa, Dorothée Ducoux, Benoît Marin, Thierry Dantoine, Pierre-Marie Preux, Achille Tchalla
IMPORTANCE: Dental neglect and high levels of unmet dental needs are becoming increasingly prevalent among elderly residents of long-term care facilities, although frail, elderly, and dependent populations are the most in need of professional dental care. Little is known about the validity of teledentistry for diagnosing dental pathology in nursing home residents. OBJECTIVES: To evaluate the accuracy of teledentistry for diagnosing dental pathology, assessing the rehabilitation status of dental prostheses, and evaluating the chewing ability of older adults living in nursing homes (using direct examination as a gold standard)...
February 21, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28236262/comparing-effects-between-music-intervention-and-aromatherapy-on-anxiety-of-patients-undergoing-mechanical-ventilation-in-the-intensive-care-unit-a-randomized-controlled-trial
#17
Chiu-Hsiang Lee, Chiung-Ling Lai, Yi-Hui Sung, Mei Yu Lai, Chung-Ying Lin, Long-Yau Lin
PURPOSE: Using patient-reported outcomes and physiological indicators to test the effects of music intervention and aromatherapy on reducing anxiety for intensive care unit (ICU) patients undergoing mechanical ventilation. METHODS: Patients with ICU admission duration >24 h were randomly assigned to a Music intervention group (n = 41), Aromatherapy group (n = 47), or Control group (rest only; n = 44). Each patient in the Music group listened to music; each patient in the Aromatherapy group received lavender essential oil massage on his/her back for 5 min; each patient in the Control group wore noise-canceling headphones...
February 24, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28235952/rete-mirabile-associated-with-pial-arteriovenous-fistula-imaging-features-with-literature-review
#18
Prabath Kumar Mondel, Rashmi Saraf, Uday S Limaye
A rete mirabile is a vascular network of intercommunicating small arteries or arterioles that replace the definitive adult artery supplying the brain. It supplies the brain in lower mammals but is not seen in normal human embryological development. A 26-year-old man presented with worsening tinnitus that was interfering with his sleep. On CT and digital subtraction angiography he was found to have a temporal lobe pial arteriovenous fistula with bilateral carotid and vertebral rete mirabile. The patient was offered open surgical and endovascular treatment options for pial arteriovenous fistula but he refused both and opted for conservative medical management...
February 24, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/28235709/role-of-erk1-2-activation-and-nnos-uncoupling-on-endothelial-dysfunction-induced-by-lysophosphatidylcholine
#19
Gianne P Campos-Mota, Juliana M Navia-Pelaez, Jessica Cristina Araujo-Souza, Nikos Stergiopulos, Luciano S A Capettini
BACKGROUND AND AIMS: Lysophosphatidylcholine (LPC) - a main component of oxidized LDL - is involved in endothelial dysfunction that precedes atherosclerosis, with an increased superoxide anions and a reduced NO production via endothelial NO synthase (eNOS) uncoupling. However, there is no evidence about the mechanisms involved in neuronal NOS (nNOS) uncoupling. Extracellular signal-regulated kinase (ERK) is related to the control of NO production and inflammatory gene transcription activation in atherosclerosis...
November 18, 2016: Atherosclerosis
https://www.readbyqxmd.com/read/28235651/ascending-aorta-common-hepatic-artery-bypass-for-mesenteric-revascularization
#20
Yuri Murakami, Naoki Toya, Soichiro Fukushima, Eisaku Ito, Tadashi Akiba, Takao Ohki
INTRODUCTION: Chronic aortic occlusion usually occurs from the infrarenal branch to the terminal aorta. We report the case of a patient with an occlusion that began at the suprarenal artery, and there was also occlusion of the superior mesenteric artery and extreme stenosis of the celiac artery. Antegrade bypass from the ascending aorta to the common hepatic artery was performed. PRESENTATION OF CASE: A 59-year-old patient presented to our hospital with uremia due to acute anuric renal failure and anorexia...
February 3, 2017: International Journal of Surgery Case Reports
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