keyword
MENU ▼
Read by QxMD icon Read
search

Viral activation transfusion study

keyword
https://www.readbyqxmd.com/read/27914462/recombinant-mhc-tetramers-for-isolation-of-virus-specific-cd8-cells-from-healthy-donors-potential-approach-for-cell-therapy-of-posttransplant-cytomegalovirus-infection
#1
A S Vdovin, S Y Filkin, P R Yefimova, S A Sheetikov, N M Kapranov, Y O Davydova, E S Egorov, E G Khamaganova, M Y Drokov, L A Kuzmina, E N Parovichnikova, G A Efimov, V G Savchenko
Patients undergoing allogeneic hematopoietic stem cell transplantation have a high risk of cytomegalovirus reactivation, which in the absence of T-cell immunity can result in the development of an acute inflammatory reaction and damage of internal organs. Transfusion of the virus-specific donor T-lymphocytes represents an alternative to a highly toxic and often ineffective antiviral therapy. Potentially promising cell therapy approach comprises transfusion of cytotoxic T-lymphocytes, specific to the viral antigens, immediately after their isolation from the donor's blood circulation without any in vitro expansion...
November 2016: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/27881659/glycosyl-phosphatidylinositol-gpi-anchored-anti-hiv-scfv-efficiently-protect-cd4-t-cells-from-hiv-1-infection-and-deletion-in-hu-pbl-mice
#2
Chaobaihui Ye, Weiming Wang, Liang Cheng, Guangming Li, Michael Wen, Qi Wang, Qing Zhang, Dan Li, Paul Zhou, Lishan Su
: Despite the success in viral inhibition and CD4 T cell recovery by highly active antiretroviral treatment (HAART), HIV-1 is still not curable due to the persistence of HIV-1 reservoir during treatment. One patient with acute myeloid leukemia who received allogeneic hematopoietic stem cell transplantation from homozygous CCR5 Δ32 donor has had no detectable viremia for 9 years after HAART cessation. This case has inspired a field of HIV-1 cure research focusing on engineering HIV-1 resistance of permissive cells...
November 23, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27735998/hepatitis-c-virus-infection-in-southwestern-saudi-arabia-are-we-still-in-the-plateau-phase
#3
Suliman M Al Humayed, Awad A El-Mekki, Ahmed A Mahfouz
The aim was to study the seroprevalence of Hepatitis C virus (HCV) infection and related risk factors in Aseer region in southwestern Saudi Arabia, the region known to be of the highest endemicity of viral hepatitis. In a cross-sectional study, all participants were interviewed using structured questionnaire. HCV infection was diagnosed using fourth-generation ELISA. All positive and equivocal HCV serology results were further confirmed by using a qualitative confirmatory RT-PCR. The study enrolled 10,234 participants...
October 13, 2016: Journal of Medical Virology
https://www.readbyqxmd.com/read/27522103/unresolved-clinical-aspects-and-safety-hazards-of-blood-derived-ev-mv-in-stored-blood-components-from-personal-memory-lanes-to-newer-perspectives-on-the-roles-of-ev-mv-in-various-biological-phenomena
#4
REVIEW
Jerard Seghatchian, Jean Amiral
Blood cells generate heterogeneous populations of vesicles that are delivered, as small-specialized packages of highly active cell fragments in blood circulation, having almost similar functional activities, as the mother cells. These so called extracellular vesicles are the essential part of an energy-dependent natural apoptotic process; hence their beneficial and harmful biological functions cannot be ignored. Evidence is accumulating, that cellular derived vesicles, originate from all viable cells including: megakaryocytes, platelets, red blood cells, white blood cells and endothelial cells, the highest in proportions from platelets...
August 2016: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/27249529/hcv-non-1b-genotypes-in-injecting-drug-users-from-romania
#5
Simona Ruta, Camelia Sultana, Cristiana Oprea, Codruta Vagu, Emanoil Ceausu, Costin Cernescu
INTRODUCTION: Chronic hepatitis C cases diagnosed in Romania were mostly related to unsafe parenteral treatments and blood transfusions; HCV genotype 1b was prevalent. During the last decade, an increasing number of HCV infections was reported among people who inject drugs (PWID). The aim of the current study was to test if this epidemiological shift triggered a diversification of the circulating viral strains. METHODOLOGY: HCV genotypes were determined by reverse hybridization in 130 HCV-infected PWID (87...
2016: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/27167507/effect-of-increased-agitation-speed-on-pathogen-inactivation-efficacy-and-in-vitro-quality-in-uvc-treated-platelet-concentrates
#6
P F van der Meer, U Gravemann, D de Korte, C Sumian, F Tolksdorf, T H Müller, A Seltsam
BACKGROUND AND OBJECTIVES: Pathogen inactivation technologies require continuous development for adjustment to different blood components and products. With Theraflex UV-Platelets, a system using shortwave ultraviolet C (UVC) light (254 nm), efficient mixing of platelet concentrates (PCs) during UVC treatment is essential to ensure homogeneous illumination of the blood components. In this study, we investigated the impact of increasing the agitation speed during UVC treatment on pathogen inactivation capacity and platelet quality...
August 2016: Vox Sanguinis
https://www.readbyqxmd.com/read/27157168/sero-epidemiological-study-of-hepatitis-e-virus-among-thalassemia-as-high-risk-patients-a-cross-sectional-survey-in-jahrom-southern-iran
#7
Abdolreza Sotoodeh Jahromi, Abbas Ahmadi-Vasmehjani, Hassan Zabetian, Hossein Hakimelahi, Alireza Yusefi, Mohammad Sadegh Sanie, Somayehsadat Talebnia Jahromi, Masoud Ghanei, Abdolali Sapidkar, Saiedeh Erfanian, Abdolhossien Madani, Farshid Kafilzadeh, Mohammad Kargar, Mohammad Hojjat-Farsangi
Hepatitis E virus (HEV) could be cause of viral hepatitis in the developing countries and cause severe epidemics. According to other studies, blood transfusion as a probable route of HEV infection has been suggested. An infection with hepatitis agents such as HEV causes active liver failure in multi-transfusion patients in particular thalassemia. The purpose of this study determines the seropositivity of anti-HEV antibodies in thalassemia individuals in Jahrom. In a cross-sectional study, sera from 110 thalassemia were collected between 2013 and 2014...
September 1, 2016: Global Journal of Health Science
https://www.readbyqxmd.com/read/27015949/coinfection-of-schistosoma-species-with-hepatitis-b-or-hepatitis-c-viruses
#8
REVIEW
Amy Abruzzi, Bernard Fried, Sukaina B Alikhan
Although a considerable number of studies have been undertaken to date, it is still controversial as to whether or not coinfection with schistosomiasis increases the susceptibility to or progression from Hepatitis B virus (HBV) or Hepatitis C virus (HCV) infection. This review is a closer examination of the key studies conducted on human populations on clinical factors that were published in English between 1975 and January 2015. Our review is mainly based on tables containing the salient information, which are arranged first by study population, country of study and publication date...
2016: Advances in Parasitology
https://www.readbyqxmd.com/read/26817642/a-study-protocol-for-a-randomised-controlled-trial-evaluating-clinical-effects-of-platelet-transfusion-products-the-pathogen-reduction-evaluation-and-predictive-analytical-rating-score-prepares-trial
#9
Paula F Ypma, Pieter F van der Meer, Nancy M Heddle, Joost A van Hilten, Theo Stijnen, Rutger A Middelburg, Tor Hervig, Johanna G van der Bom, Anneke Brand, Jean-Louis H Kerkhoffs
INTRODUCTION: Patients with chemotherapy-induced thrombocytopaenia frequently experience minor and sometimes severe bleeding complications. Unrestrictive availability of safe and effective blood products is presumed by treating physicians as well as patients. Pathogen reduction technology potentially offers the opportunity to enhance safety by reducing bacterial and viral contamination of platelet products along with a potential reduction of alloimmunisation in patients receiving multiple platelet transfusions...
2016: BMJ Open
https://www.readbyqxmd.com/read/26811632/status-of-hepatitis-c-virus-vaccination-recent-update
#10
REVIEW
Kouka Saadeldin Abdelwahab, Zeinab Nabil Ahmed Said
Hepatitis C virus (HCV) infection is still a major public health problem worldwide since its first identification in 1989. At the start, HCV infection was post-transfusion viral infection, particularly in developing countries. Recently, due to iv drug abuse, HCV infection became number one health problem in well-developed countries as well. Following acute HCV infection, the innate immune response is triggered in the form of activated coordinated interaction of NK cells, dendritic cells and interferon α. The acquired immune response is then developed in the form of the antibody-mediated immune response (ABIR) and the cell-mediated immune response (CMIR)...
January 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/26662440/prevalence-of-hepatitis-a-viral-rna-and-antibodies-among-chinese-blood-donors
#11
P Sun, N Su, F Z Lin, L Ma, H J Wang, X Rong, Y D Dai, J Li, Z W Jian, L H Tang, W Xiao, C Q Li
Like other developing countries, China was reported to have a relatively high seroprevalence of anti-hepatitis A antibodies (anti-HAV). However, no studies have evaluated the prevalence of anti-HAV and HAV RNA among voluntary blood donors with or without elevated serum alanine transaminase (ALT) levels. Anti-HAV antibodies were detected using an enzyme-linked immunosorbent assay, and reverse transcription quantitative polymerase chain reaction was carried out for detection of HAV RNA. In the current study, we analyzed a total of 450 serum samples with elevated ALT levels (≥40 U/L) and 278 serum samples with non-elevated ALT levels...
2015: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/26040073/use-of-serum-levels-of-proinflammatory-cytokine-il-1%C3%AE-in-chronic-hepatitis-c
#12
Nenad Vanis, Amila Mehmedović, Rusmir Mesihović
Immunoregulatory cytokines influence the persistence of hepatitis C virus chronic infection and the extent of liver damage. Interleukin-1 plays an important role in the inflammatory process. Some studies have demonstrated that IL-1 production was impaired in patients with chronic infections of hepatitis C virus, implying that IL-1 may play a role in viral clearance. In this study, along with routine laboratory tests, has been performed the analysis of serum levels of proinflammatory cytokine IL-1α in order of better understanding and monitoring of chronic hepatitis C...
March 2015: Collegium Antropologicum
https://www.readbyqxmd.com/read/26034552/study-of-the-associations-between-tt-virus-single-and-mixed-infections-with-leukemia
#13
Marjan Shaheli, Ramin Yaghobi, Abbasali Rezaeian, Mahdiyar Iravani Saadi, Mani Ramzi
BACKGROUND: The pathogenic association of Transfusion Transmitted Virus or Torque teno Virus (TT Virus) single and mixed infections with leukemia was under evaluation in these years but confront with controversies. This hypothesis is based on the higher prevalence of TT Virus infection in patients with leukemia compared with controls. OBJECTIVES: The aim of this study was to determine the frequency of TT Virus, Cytomegalovirus (CMV), Hepatitis B Virus (HBV), and Hepatitis C Virus (HCV) infections in patients with leukemia and healthy controls...
April 2015: Jundishapur Journal of Microbiology
https://www.readbyqxmd.com/read/25425697/downregulation-of-cytokines-and-chemokines-by-gb-virus-c-after-transmission-via-blood-transfusion-in-hiv-positive-blood-recipients
#14
RANDOMIZED CONTROLLED TRIAL
Marion C Lanteri, Farnaz Vahidnia, Sylvia Tan, Jack T Stapleton, Philip J Norris, John Heitman, Xutao Deng, Sheila M Keating, Don Brambilla, Michael P Busch, Brian Custer
BACKGROUND: An association between GB virus C (GBV-C) and improved outcomes of human immunodeficiency virus (HIV) infection has been reported in HIV-positive individuals with active GBV-C coinfection. This study provides insights into the immune mechanisms underlying the protective role of GBV-C in HIV-infected patients. METHODS: The concentrations of 64 cytokines and chemokines were measured in plasma samples obtained from the Viral Activation Transfusion Study cohort before transfusion and longitudinally from 30 patients positive for both HIV and GBV-C (hereafter, "cases") and 30 patients positive for HIV and negative for GBV-C (hereafter, "controls")...
May 15, 2015: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/25018803/the-prevalence-of-hepatitis-b-virus-e-antigen-among-ghanaian-blood-donors
#15
Tanko Rufai, Mohamed Mutocheluh, Kwaku Kwarteng, Elliot Dogbe
Hepatitis B viral infection is an important clinical problem due to its worldwide distribution and potential of adverse sequelae, including hepatocellular carcinoma (HCC). We studied the prevalence of hepatitis B virus 'e' antigen (HBeAg) among individuals determined to be hepatitis B virus (HBV) surface antigen-positive and analyzed the gender/age category associated with more active HBV infection and whether alteration in the levels of alanine aminotransferase could be associated with HBeAg positivity. A total of 150 prospective blood donors who tested positive for hepatitis B surface antigen (HBsAg) at the blood transfusion center of the Komfo Anokye Teaching Hosptital (KATH), Kumasi were randomly selected for the study...
2014: Pan African Medical Journal
https://www.readbyqxmd.com/read/24980041/artificial-oxygen-carrier-with-pharmacologic-actions-of-adenosine-5-triphosphate-adenosine-and-reduced-glutathione-formulated-to-treat-an-array-of-medical-conditions
#16
Jan Simoni, Grace Simoni, John F Moeller, Mario Feola, Donald E Wesson
Effective artificial oxygen carriers may offer a solution to tackling current transfusion medicine challenges such as blood shortages, red blood cell storage lesions, and transmission of emerging pathogens. These products, could provide additional therapeutic benefits besides oxygen delivery for an array of medical conditions. To meet these needs, we developed a hemoglobin (Hb)-based oxygen carrier, HemoTech, which utilizes the concept of pharmacologic cross-linking. It consists of purified bovine Hb cross-linked intramolecularly with open ring adenosine-5'-triphosphate (ATP) and intermolecularly with open ring adenosine, and conjugated with reduced glutathione (GSH)...
August 2014: Artificial Organs
https://www.readbyqxmd.com/read/24937930/use-of-serum-levels-of-proinflammatory-cytokine-il-1alpha-in-chronic-hepatitis-b
#17
COMPARATIVE STUDY
Zora Vukobrat-Bijedic, Amila Mehmedovic, Amir Redzepovic, Bisera Gogov
BACKGROUND: The reasons for the chronic viral persistence of hepatitis B virus infection (HBV) are unknown, but are probably related to host immune factors. Cytokines play a significant role in immune defense. Interleukin-1 (IL-1) is a proinflammatory cytokine and some studies have demonstrated that IL-1 production was impaired in patients with chronic infections of hepatitis B virus, implying that IL-1 may play a role in viral clearance, progression of fibrosis and in malignant potential of HBV...
2014: Medical Archives
https://www.readbyqxmd.com/read/24898457/neonatal-blood-transfusion-as-transmission-route-in-chronic-hepatitis-c
#18
Afrodite Psaros Einberg, Gudrun Lindh, Ingegerd Hökeberg, Nikos Papadogiannakis, Björn Fischler
BACKGROUND: The aim of this study was to investigate if neonatal transfusions could underlie chronic hepatitis C in adults for whom the disease transmission route was previously unknown. STUDY DESIGN AND METHODS: Questionnaires were sent to 255 patients with chronic hepatitis C born in Sweden in 1960 to 1975. The medical records of 230 of the patients, of whom 98 (43%) had unknown transmission route, were studied regarding the occurrence of neonatal blood transfusions...
May 2014: Transfusion
https://www.readbyqxmd.com/read/24866083/short-communication-prevalence-and-risk-factors-for-human-t-cell-lymphotropic-virus-infection-in-southern-brazilian-hiv-positive-patients
#19
Leonardo Ramos Galetto, Vagner Ricardo Lunge, Jorge Umberto Béria, Daniela Cardoso Tietzmann, Airton Tetelbom Stein, Daniel Simon
HIV/human T cell lymphotropic virus (HTLV) coinfection has a large range of prevalence in the different risk groups and geographic regions of the world. Most of the HTLV-infected people live in geographic areas where the virus is endemic, as it happens in Brazil. The aim of this study was to identify HTLV prevalence and risk factors in HIV-positive patients. A cross-sectional study was conducted with 580 HIV-positive patients (mean age of 40.6 years and 45.0% men) from a specialized HIV/AIDS diagnosis and treatment center in Southern Brazil...
September 2014: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/24839364/rate-of-seroconversion-in-repeat-blood-donors-at-the-national-blood-centre-kuala-lumpur
#20
A Nafishah, M Nor Asiah, A T Nur Syimah, T H Mohd Zahari, A Yasmin, M Normi, E Anza, M Shahnaz, M Y Narazah
The World Health Organization (WHO) recommend that all donated blood are to be screened for at least three viral infections [human immunodeficiency virus (HIV), hepatitis C virus (HCV), hepatitis B virus (HBV)]. The National Blood Centre, Kuala Lumpur (NBCKL) aims to reduce transfusion transmitted infections (TTI) as it still remains as one of the major risk for blood transfusion. A cross sectional study was conducted at the National Blood Centre, Kuala Lumpur from 1st January 2009 to 31st June 2010. Data from 581,020 donors were analyzed from year 2004 to 2008...
June 2014: Indian Journal of Hematology & Blood Transfusion
keyword
keyword
32757
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"