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https://www.readbyqxmd.com/read/29338495/clinical-challenges-in-de-novo-pediatric-acute-myeloid-leukemia
#1
Kim Klein, Valérie de Haas, Gertjan J L Kaspers
Although the prognosis of pediatric acute myeloid leukemia (pAML) has improved, with current survival rates up to 75%, relapse rates remain high. Areas covered: The low number of patients, the heterogeneous genomic landscape of AML, novel diagnostic techniques, divergent available treatment protocols, and dose-limiting toxicity of conventional agents all contribute to the complexity of AML treatment. This review gives an overview of the current clinical challenges with respect to diagnostics, treatment, and supportive care in pAML...
January 17, 2018: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/29329442/conventional-radiofrequency-thermocoagulation-vs-pulsed-radiofrequency-neuromodulation-of-ganglion-impar-in-chronic-perineal-pain-of-nononcological-origin
#2
Hammad Usmani, G P Dureja, Roshan Andleeb, Nazia Tauheed, Naiyer Asif
Background: Chronic nononcological perineal pain has been effectively managed by ganglion Impar block. Chemical neurolysis, cryoablation, and radiofrequency ablation have been the accepted methods of blockade. Recently, pulsed radiofrequency, a novel variant of conventional radiofrequency, has been used for this purpose. Study Design: This was a prospective, randomized, double-blind study. Setting: Two different interventional pain management centers in India...
January 10, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29329055/altered-brain-structure-in-women-with-premenstrual-syndrome
#3
Peng Liu, Ying Wei, Yingying Fan, Ru Li, Yanfei Liu, Geliang Wang, Yichen Wei, Yong Pang, Demao Deng, Wei Qin
BACKGROUND: Functional brain abnormalities have been noted in premenstrual syndrome (PMS). However, the brain structural alterations related to PMS remain unclear. This study aimed to identify possible abnormalities in gray matter (GM) volumes and structural covariance patterns among PMS patients. METHODS: Structural magnetic resonance imaging data were obtained from 20 PMS patients and 20 healthy controls. Voxel-based morphometry (VBM) analysis was applied to examine GM volumes changes between the two groups...
January 3, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29327548/-research-of-tcm-synthetic-rehabilitation-on-the-recovery-of-wrist-joint-after-distal-radius-fractures
#4
Yong Zhao, Qing-Qing Dong, Wei-Kai Qin, An Yan, Kuan Zhang, Guo-Dong Zhao, Gang Wang, Jin-Chao Geng, Zhan-Feng Wang, Ze-Ming Lu
OBJECTIVE: To evaluate efficacy and advantages of the Traditional Chinese Medicine (TCM) synthetic rehabilitation therapy in the treatment of wrist dysfunction after distal radius fractures. METHODS: From May 2014 to October 2015, 72 patients with distal radius fracture meeting standards were treated using central randomization system for clinical research. All the patients were divided into two groups: 36 patients in test group and 36 in control group. Sixty-nine cases were finished treatment and followed up in the end...
January 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29324500/hydroxyethyl-starch-130-0-4-and-its-impact-on-perioperative-outcome-a-propensity-score-matched-controlled-observation-study
#5
Judith-Irina Pagel, Markus Rehm, Tobias Kammerer, Nikolai Hulde, Eike Speck, Josef Briegel, Falk Reinholz, Alexander Crispin, Klaus F Hofmann-Kiefer
BACKGROUND: Adverse effects of hydroxyethyl starches (HESs) have been verified in patients suffering from sepsis or kidney disease, but not in surgical patients at large. The investigation aimed to determine whether the use of HES 130/0.4 was associated with the incidence of acute postinterventional adverse events compared to Ringer's acetate alone in a perioperative setting. METHODS: This propensity score matched, controlled observational study was performed in a single-centre university hospital...
January 9, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29321998/effectiveness-of-two-different-herbal-toothpaste-formulations-in-the-reduction-of-plaque-and-gingival-inflammation-in-patients-with-established-gingivitis-a-randomized-controlled-trial
#6
Rajesh Hosadurga, Vinita Ashutosh Boloor, Sudharshan N Rao, N MeghRani
Background: Plant based toothpastes have received great attention in reducing gingival inflammation. Studies show contrasting results regarding the effectiveness of these toothpastes. In the present study, the effectiveness of two herbal tooth paste formulations in the reduction of plaque and gingival inflammation was assessed. Nicotine content in the toothpastes was assessed using GCMS. Material and methods: 50 patients with established gingivitis were included in the study...
January 2018: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29321108/surgical-stabilization-for-first-time-shoulder-dislocators-a-multicenter-analysis
#7
Caitlin M Rugg, Carolyn M Hettrich, Shannon Ortiz, Brian R Wolf, Alan L Zhang
BACKGROUND: Anterior shoulder dislocations in young patients are associated with high rates of recurrent instability. Although some surgeons advocate for surgical stabilization after a single dislocation event in this population, there is sparse research evaluating surgical treatment for first-time dislocators. METHODS: Patients undergoing surgical stabilization for anterior shoulder instability were prospectively enrolled at multiple institutions from 2015-2017 and stratified by number of dislocations before surgery...
January 8, 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29316815/effect-of-l-prp-treatment-on-wound-healing-after-surgical-skin-incision-in-an-experimental-animal-model
#8
Agata Cieślik-Bielecka, Marcin Pierchała, Aleksandra Królikowska, Paweł Reichert
AIM OF THE STUDY: The aim of the study was to evaluate the effect of leukocyte- and platelet-rich plasma (L-PRP) treatment on a noncomplicated would healing after surgical skin incision in an experimental animal model. MATERIALS AND METHODS: The blood from 64 male Wistar rats was used to prepare L-PRP before a transverse dorsal incision was made and consecutively closed. At the same time after the surgery was completed, autologous L-PRP in the rats from the L-PRP group (n = 32) and NaCl in the control group (n = 32) were injected subcutaneously into the wound...
January 9, 2018: Connective Tissue Research
https://www.readbyqxmd.com/read/29315661/what-is-changed-in-hbv-molecular-epidemiology-in-italy
#9
REVIEW
Alessia Lai, Caterina Sagnelli, Alessandra Lo Presti, Eleonora Cella, Silvia Angeletti, Silvia Spoto, Sebastiano Costantino, Evangelista Sagnelli, Massimo Ciccozzi
Hepatitis B virus (HBV) infection represents the most common cause of chronic liver diseases worldwide. Consequently, to the introduction of the universal HBV vaccination program, the prevalence of hepatitis B surface antigen was markedly reduced and less than 1% of the population of Western Europe and North America is chronically infected. To date, despite great advances in therapeutics, HBV chronic infection is considered an incurable disease. Ten hepatitis B virus genotypes (A-J) and several subgenotypes have been identified so far, based on intergroup divergences of 8% and 4%, respectively, in the complete viral genome...
January 9, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29311299/testing-the-impact-and-durability-of-a-group-malleability-intervention-in-the-context-of-the-israeli-palestinian-conflict
#10
Amit Goldenberg, Smadar Cohen-Chen, J Parker Goyer, Carol S Dweck, James J Gross, Eran Halperin
Fostering perceptions of group malleability (teaching people that groups are capable of change and improvement) has been shown to lead to short-term improvements in intergroup attitudes and willingness to make concessions in intractable conflicts. The present study, a field intervention involving 508 Israelis from three locations in Israel, replicated and substantially extended those findings by testing the durability of a group malleability intervention during a 6-month period of frequent violence. Three different 5-hour-long interventions were administered as leadership workshops...
January 8, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29310563/evaluation-of-factors-associated-with-achievement-of-biventricular-repair-after-bilateral-pulmonary-artery-banding-in-patients-with-interrupted-aortic-arch
#11
Yasuhiro Hirano, Noboru Inamura, Yukiko Kawazu, Hisaaki Aoki, Futoshi Kayatani, Shigemitsu Iwai, Hiroaki Kawata
BACKGROUND: At our institution, we perform bilateral pulmonary artery banding (BPAB) as the first-stage palliation for interrupted aortic arch (IAA) with low birth weight or severe subaortic stenosis (SAS). The present study aimed to identify factors that may influence the decision regarding the type of second-stage operation, that is, univentricular palliation or biventricular repair, in these patients. METHODS: Cardiac catheterization and angiographic data of nine patients with IAA who underwent initial BPAB and subsequent univentricular or biventricular repair were retrospectively analyzed...
January 2018: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/29308569/inducible-no-synthase-mrna-expression-and-infiltration-of-rats-myocardium-with-inflammatory-cells-in-2-4-hours-after-modeled-permanent-ischemia-or-ischemia-reperfusion
#12
E V Ivanov, A B Berdalin, Yu L Volkova, M A Markov, M P Davydova, S A Gavrilova
Expression of inducible NO-synthase mRNA and myocardial infiltration with neutrophils were studied in rats with modeled permanent ischemia and ischemia/reperfusion models. Expression of inducible NO synthase mRNA in the ischemic region increased significantly in 3, 3.5, and 4 h in modeled ischemia/reperfusion and in 3.5 and 4 h in permanent ischemia. Myocardial infiltration with neutrophils was significantly higher than in intact controls throughout the experiment without significant intergroup differences...
January 8, 2018: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29307902/a-randomised-controlled-trial-comparing-proseal-laryngeal-mask-airway-i-gel-and-laryngeal-tube-suction-d-under-general-anaesthesia-for-elective-surgical-patients-requiring-controlled-ventilation
#13
Bikramjit Das, Rahul Varshney, Subhro Mitra
Background and Aims: The ProSeal™ laryngeal mask airway (PLMA), i-gel™ and Laryngeal Tube Suction-D (LTS-D™) have previously been evaluated alone or in pair-wise comparisons but differing study designs make it difficult to compare the results. The aim of this study was to compare the clinical performance of these three devices in terms of efficacy and safety in patients receiving mechanical ventilation during elective surgical procedures. Methods: This prospective, randomised, double-blind study was conducted on 150 American Society of Anesthesiologists physical status I-II patients, randomly allocated into 3 groups, undergoing elective surgical procedures under general anaesthesia...
December 2017: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/29307742/is-double-metatarsal-osteotomy-superior-to-proximal-chevron-osteotomy-in-treatment-of-hallux-valgus-with-increased-distal-metatarsal-articular-angle
#14
Chul Hyun Park, Woo-Chun Lee
We compared the results of proximal chevron osteotomy and double metatarsal osteotomy for hallux valgus with an increased distal metatarsal articular angle (DMAA). From October 2008 to December 2012, first metatarsal osteotomies were performed in 64 patients (69 feet) with symptomatic hallux valgus associated with an increased DMAA. Proximal chevron with Akin osteotomy and lateral soft tissue release was performed in 46 feet (PCO group); double metatarsal osteotomy and Akin osteotomy without lateral soft tissue release was performed in 23 feet (DMO group)...
January 5, 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29301732/gastrointestinal-lymphomas-french-intergroup-clinical-practice-recommendations-for-diagnosis-treatment-and-follow-up-snfge-ffcd-gercor-unicancer-sfcd-sfed-sfro-sfh
#15
REVIEW
Tamara Matysiak-Budnik, Bettina Fabiani, Christophe Hennequin, Catherine Thieblemont, Georgia Malamut, Guillaume Cadiot, Olivier Bouché, Agnès Ruskoné-Fourmestraux
INTRODUCTION: This document is a summary of the French Intergroup guidelines on the management of gastro-intestinal lymphomas, available on the web-site of the French Society of Gastroenterology, SNFGE (www.tncd.org), updated in September 2017. METHODS: This collaborative work was realised under the auspices of several French medical societies and involved clinicians with specific expertise in the field of gastrointestinal lymphomas, including gastroenterologists, haematologists, pathologists, and radiation oncologist, representing the major French or European clinical trial groups...
December 18, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29291184/predictors-of-favorable-soft-tissue-profile-outcomes-following-class-ii-twin-block-treatment
#16
Ji-Eun Kim, Su-Jung Mah, Tae-Woo Kim, Su-Jung Kim, Ki-Ho Park, Yoon-Goo Kang
Objective: The aim of this study was to determine cephalometric factors that help predict favorable soft-tissue profile outcomes following treatment with the Class II Twin-block appliance. Methods: Pre- and post-treatment lateral cephalograms of 45 patients treated with the Class II Twin-block appliance were retrospectively analyzed. Profile silhouettes were drawn from the cephalograms and evaluated by three orthodontists in order to determine the extent of improvement...
January 2018: Korean Journal of Orthodontics
https://www.readbyqxmd.com/read/29290089/non-interventional-1-year-follow-up-study-of-peri-implant-soft-tissues-following-previous-soft-tissue-augmentation-and-crown-insertion-in-single-tooth-gaps
#17
Samuel Huber, Marco Zeltner, Christoph H F Hämmerle, Ronald E Jung, Daniel S Thoma
AIM: To assess peri-implant soft tissue dimensions at implant sites, previously augmented with a collagen matrix (VCMX) or an autogenous subepithelial connective tissue graft (SCTG), between crown insertion and 1 year. METHODS: Twenty patients with single-tooth implants received soft tissue augmentation prior to abutment connection randomly using VCMX or SCTG. Following abutment connection 3 months later, final reconstructions were fabricated and inserted (baseline)...
December 31, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29289919/regulating-shared-reality-with-micro-dynamics-in-the-form-of-conversation
#18
REVIEW
Namkje Koudenburg
One of the central goals within communication is to establish whether people are on the same wavelength. Although such assessment can occur objectively, by exchanging and comparing viewpoints, people may also derive a sense of shared reality subjectively, through micro-dynamics in the form of conversation that inform them whether their views are shared. The present review outlines the role of these micro-dynamics in developing and regulating a shared reality. It focuses on three different contexts: intergroup communication, computer mediated communication and communication within intimate relationships...
December 14, 2017: Current Opinion in Psychology
https://www.readbyqxmd.com/read/29289757/tandem-autologous-hematopoietic-cell-transplantation-for-patients-with-primary-progressive-or-recurrent-hodgkin-lymphoma-a-swog-and-blood-marrow-transplant-clinical-trials-network-phase-ii-trial-swog-s0410-bmt-ctn-0703
#19
Eileen P Smith, Hongli Li, Jonathan W Friedberg, Louis S Constine, Lisa M Rimsza, James R Cook, Ginna G Laport, Leslie L Popplewell, Leona A Holmberg, Sonali M Smith, Michael LeBlanc, Stephen J Forman, Richard I Fisher, Patrick J Stiff
Based on promising pilot data, a Phase II tandem autologous hematopoietic stem cell transplant (AHSCT) trial for relapsed/refractory Hodgkin Lymphoma (HL) was performed in the US intergroup setting to determine if long-term progression-free survival (PFS) could be improved. Patients were enrolled after salvage therapy and stem cell collection. Sensitivity to salvage was defined by 1999 Standardized Response Criteria and did not include FDG-PET. Cycle 1 consisted of melphalan 150 mg/m2 with half of the stem cells...
December 28, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29286582/alveolar-soft-part-sarcoma-in-children-and-adolescents-the-european-paediatric-soft-tissue-sarcoma-study-group-prospective-trial-epssg-nrsts-2005
#20
Bernadette Brennan, Ilaria Zanetti, Daniel Orbach, Soledad Gallego, Nadine Francotte, Max Van Noesel, Anna Kelsey, Michela Casanova, Gian Luca De Salvo, Gianni Bisogno, Andrea Ferrari
BACKGROUND: As alveolar soft part sarcomas (ASPS) are rare with no prospective series within pediatric sarcoma trials, the European Paediatric Soft Tissue Sarcoma Study Group (EpSSG) examined the clinical data and outcomes of ASPS enrolled in a multinational study of nonrhabdomyosarcoma soft tissue sarcomas (NRSTS). PATIENTS AND METHODS: Twenty-two patients with ASPS were enrolled into the EpSSG NRSTS 2005 study. After surgical resection, subsequent treatment depended on the stratification of patients for completeness of resection and Intergroup Rhabdomyosarcoma Study (IRS) stage, size, and French Federation of Cancer Centres Sarcoma Group (FNCLCC) grade...
December 29, 2017: Pediatric Blood & Cancer
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