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https://www.readbyqxmd.com/read/29334627/testosterone-dhea-and-dhea-s-in-patients-with-schizophrenia-a-systematic-review-and-meta-analysis
#1
REVIEW
Błażej Misiak, Dorota Frydecka, Olga Loska, Ahmed A Moustafa, Jerzy Samochowiec, Justyna Kasznia, Bartłomiej Stańczykiewicz
Neuroactive steroids, including testosterone, dehydroepiandrosterone (DHEA) and its sulfate (DHEA-S) might play an important role in the pathophysiology of schizophrenia. Therefore, we performed a systematic review and meta-analysis of studies comparing the levels of testosterone, DHEA and DHEA-S in patients with schizophrenia and healthy controls. We searched electronic databases from their inception until Oct 29, 2017. Effect size (ES) estimates were calculated as Hedges' g. Data analysis was performed using random-effects models...
January 9, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29332629/psychobiological-stress-in-vital-exhaustion-findings-from-the-men-stress-40-study
#2
Emilou Noser, Susanne Fischer, Jessica Ruppen, Ulrike Ehlert
OBJECTIVE: Despite the increased risk for cardiovascular morbidity associated with vital exhaustion (VE), the underlying pathophysiological mechanisms remain unclear. Allostatic load may constitute the missing link between VE and cardiovascular diseases. The aim of the present study was to investigate whether men with different degrees of VE would differ in terms of allostatic load, chronic stress, and social support. METHODS: The Men Stress 40+ study sample consisted of N=121 apparently healthy men aged 40 to 75years...
February 2018: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/29322301/effects-of-short-term-dhea-intake-on-hormonal-responses-in-young-recreationally-trained-athletes-modulation-by-gender
#3
Katia Collomp, Corinne Buisson, Nicolas Gravisse, Soraya Belgherbi, Zakaria Labsy, Manh-Cuong Do, Olivier Gagey, Sophie Dufay, Nancy Vibarel-Rebot, Michel Audran
BACKGROUND: Dehydroepiandrosterone (DHEA) figures on the World Anti-Doping Agency list of prohibited substances in sport because it is assumed that athletes expect a significant increase in testosterone through DHEA administration. The literature on the hormonal effects of DHEA intake nevertheless appears to be very scant in healthy young subjects, especially women. PURPOSE: We examined the effects of DHEA on adrenal and gonadal hormones, IGF1 and free T3 in healthy young male and female recreationally trained volunteers...
January 10, 2018: Endocrine
https://www.readbyqxmd.com/read/29281066/serum-dehydroepiandrosterone-sulphate-psychosocial-factors-and-musculoskeletal-pain-in-workers
#4
A Marinelli, A Prodi, G Pesel, F Ronchese, M Bovenzi, C Negro, F Larese Filon
Background: The serum level of dehydroepiandrosterone sulphate (DHEA-S) has been suggested as a biological marker of stress. Aims: To assess the association between serum DHEA-S, psychosocial factors and musculoskeletal (MS) pain in university workers. Methods: The study population included voluntary workers at the scientific departments of the University of Trieste (Italy) who underwent periodical health surveillance from January 2011 to June 2012...
December 21, 2017: Occupational Medicine
https://www.readbyqxmd.com/read/29244084/the-value-of-peri-operative-levels-of-acth-dhea-and-dhea-s-and-tumor-size-in-predicting-recurrence-of-cushing-s-disease
#5
Nadine El Asmar, Aman Rajpal, Warren R Selman, Baha M Arafah
Background and Objectives: Despite the development of hypocortisolemia after corticotroph surgical adenomectomy, 15-20% patients have recurrence of Cushing's disease (CD). In this study, we investigated the impact of tumor size and the value of peri-operative assessment of ACTH and adrenal steroid levels in predicting recurrence. Methods: Peri-operatively, no glucocorticoids were administered until the serum cortisol was ≤ 3 ug/dL. Blood samples were obtained before and repeatedly after adenomectomy in 79 patients with CD...
December 13, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29220883/association-of-adrenal-hormone-metabolites-and-mortality-over-a-6-year-follow-up-in-copd-patients-with-acute-exacerbation
#6
Seline Zurfluh, Manuela Nickler, Manuel Ottiger, Christian Steuer, Alexander Kutz, Mirjam Christ-Crain, Werner Zimmerli, Robert Thomann, Claus Hoess, Christoph Henzen, Luca Bernasconi, Andreas Huber, Beat Mueller, Philipp Schuetz
BACKGROUND: The release of hormones from the adrenal gland is vital in acute and chronic illnesses such as chronic obstructive pulmonary disease (COPD) involving recurrent exacerbations. Using a metabolomic approach, we aim to investigate associations of different adrenal hormone metabolites with short- and long-term mortality in COPD patients. METHODS: We prospectively followed 172 COPD patients (median age 75 years, 62% male) from a previous Swiss multicenter trial...
December 7, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29176595/the-presence-of-nonfunctioning-adrenal-incidentalomas-increases-arterial-hypertension-frequency-and-severity-and-is-associated-with-cortisol-levels-after-dexamethasone-suppression-test
#7
Mariana Arruda, Emanuela Mello Ribeiro Cavalari, Marcela Pessoa de Paula, Felipe Fernandes Cordeiro de Morais, Guilherme Furtado Bilro, Maria Caroline Alves Coelho, Nathalie Anne de Oliveira E Silva de Morais, Diana Choeri, Aline Moraes, Leonardo Vieira Neto
There are limited data regarding the frequency of hypertension in nonfunctioning adrenal incidentaloma (NFAI). Our objectives were to investigate rates of hypertension and resistant hypertension in NFAI patients, and compare them to a control group without adrenal adenoma. We also aimed to evaluate the relationship between cortisol levels after 1 mg-dexamethasone suppression test (DST) and hypertension in NFAI patients. We selected 40 patients with NFAI and 40 control patients over the age of 18 without adrenal lesions on abdominal imaging...
November 24, 2017: Journal of Human Hypertension
https://www.readbyqxmd.com/read/29175500/stress-hormones-and-verbal-memory-in-young-people-over-the-first-12-weeks-of-treatment-for-psychosis
#8
Kelly A Allott, Hok Pan Yuen, Cali F Bartholomeusz, Marta Rapado-Castro, Christina Phassouliotis, Felicity Butselaar, Stephen J Wood, Tina-Marie Proffitt, Greg Savage, Lisa J Phillips, Sarah Bendall, Connie Markulev, Renate L E P Reniers, Christos Pantelis, Lara Baldwin, Patrick D McGorry, Belinda Garner
AIMS: Memory impairment in psychosis may be mediated through detrimental effects of hypothalamic-pituitary-adrenal (HPA) axis function. This study prospectively investigated the relationship between cortisol, sulphate dehydroepiandrosterone (DHEA(S) and cortisol: DHEA(S) ratio and memory in 35 first-episode psychosis (FEP) patients during the first 12 weeks of treatment and 23 healthy controls (HC). METHODS: Morning blood sampling and tests of attention, working memory and verbal memory occurred at baseline and 12-week follow-up...
November 21, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29171317/basal-blood-dhea-s-cortisol-levels-predicts-emdr-treatment-response-in-adolescents-with-ptsd
#9
Mirac Baris Usta, Yusuf Yasin Gumus, Gokce Nur Say, Abdullah Bozkurt, Berkan Şahin, Koray Karabekiroğlu
OBJECTIVE: In literature, recent evidence has shown that the hypothalamic-pituitary-adrenal (HPA) axis can be dysregulated in patients with post-traumatic stress disorder (PTSD) and HPA axis hormones may predict the psychotherapy treatment response in patients with PTSD. In this study, it was aimed to investigate changing cortisol and DHEA-S levels post-eye movement desensitization and reprocessing (EMDR) therapy and the relationship between treatment response and basal cortisol, and DHEA-S levels before treatment...
November 24, 2017: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/29164484/association-between-cortisol-to-dhea-s-ratio-and-sickness-absence-in-japanese-male-workers
#10
Kumi Hirokawa, Yasuhito Fujii, Toshiyo Taniguchi, Jiro Takaki, Akizumi Tsutsumi
PURPOSE: This study aimed to investigate the association between serum levels of cortisol and dehydroepiandrosterone sulfate (DHEA-s) and sickness absence over 2 years in Japanese male workers. METHOD: A baseline survey including questions about health behavior, along with blood sampling for cortisol and DHEA-s, was conducted in 2009. In total, 429 men (mean ± SD age, 52.9 ± 8.6 years) from whom blood samples were collected at baseline were followed until December 31, 2011...
November 21, 2017: International Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/29164377/systemic-and-local-effects-of-vaginal-dehydroepiandrosterone-dhea-ncctg-n10c1-alliance
#11
Debra L Barton, Lynne T Shuster, Travis Dockter, Pamela J Atherton, Jacqueline Thielen, Stephen N Birrell, Richa Sood, Patricia Griffin, Shelby A Terstriep, Bassam Mattar, Jacqueline M Lafky, Charles L Loprinzi
BACKGROUND: Dehydroepiandrosterone (DHEA) is helpful for treating vaginal symptoms. This secondary analysis evaluated the impact of vaginal DHEA on hormone concentrations, bone turnover, and vaginal cytology in women with a cancer history. METHODS: Postmenopausal women, diagnosed with breast or gynecologic cancer, were eligible if they reported at least moderate vaginal symptoms. Participants could be on tamoxifen or aromatase inhibitors (AIs). Women were randomized to 3...
November 21, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29114265/dehydroepiandrosterone-sulfate-insulin-resistance-and-ovarian-volume-estimation-in-patients-with-polycystic-ovarian-syndrome
#12
Chrysi Christodoulaki, Eftihios Trakakis, Vasilios Pergialiotis, Periklis Panagopoulos, Charalampos Chrelias, Dimitrios Kassanos, Dimos Sioutis, Nikolaos Papantoniou, Dimitrios Xirofotos
Objective: To investigate the potential association of DHEA-S with metabolic and hormonal alterations and with disorders of ovarian morphology. Materials and methods: The present study was based on women with PCOS that attended the Gynaecological Endocrinology - Paediatric and Adolescence Endocrinology Department of our clinic. Overall, 321 patients who met the Rotterdam ESHRE/ ASRM - Sponsored criteria for the definition of PCOS were included. Women's personal medical history was recorded, anthropometric parameters were assessed and blood was drawn for analysis of metabolic and hormonal parameters...
March 2017: Journal of Family & Reproductive Health
https://www.readbyqxmd.com/read/29091323/lower-levels-of-dehydroepiandrosterone-sulfate-are-associated-with-more-advanced-liver-fibrosis-in-chronic-hepatitis-c
#13
João Marcello de Araujo Neto, Henrique Sérgio Moraes Coelho, Maria Chiara Chindamo, Guilherme Ferreira da Motta Rezende, Vera Lúcia Nunes Pannain, Adriana Marques Caroli de Freitas Bottino, Luiz Fernando Bruzzi Porto, Ronir Raggio Luiz, Cristiane Alves Villela-Nogueira, Renata M Perez
Chronic infection with the hepatitis C virus induces liver fibrosis, but it is unknown why some patients progress to advanced fibrosis while others remain with mild disease. Recently, an inverse association between serum levels of dehydroepiandrosterone sulphate (DHEA-S) and liver fibrosis in patients with nonalcoholic fatty liver disease was described and it was postulated that dehydroepiandrosterone (DHEA) has anti-fibrotic effects. Our aim was to compare serum DHEA-S levels with liver fibrosis in hepatitis C patients...
November 1, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29067249/serum-dehydroepiandrosterone-sulfate-in-assessing-the-integrity-of-the-hypothalamic-pituitary-adrenal-axis
#14
Suranut Charoensri, Laor Chailurkit, Dittapol Muntham, Pongamorn Bunnag
OBJECTIVE: To evaluate the relationship between age- and gender-adjusted dehydroepiandrosterone sulfate (DHEA-S) levels and low-dose adrenocorticotropic hormone (ACTH) stimulation in assessing the integrity of the hypothalamic-pituitary-adrenal (HPA) axis, in patients who were at risk of HPA insufficiency, including those currently being treated with glucocorticoids. METHODS: Forty-six participants with a suspicion of secondary adrenal insufficiency were recruited from the Diabetes and Endocrinology Clinic at Ramathibodi Hospital, Mahidol University, Bangkok...
March 2017: Journal of Clinical & Translational Endocrinology
https://www.readbyqxmd.com/read/29048765/ageratum-conyzoides-l-inhibits-5-alpha-reductase-gene-expression-in-human-prostate-cells-and-reduces-symptoms-of-benign-prostatic-hypertrophy-in-otherwise-healthy-men-in-a-double-blind-randomized-placebo-controlled-clinical-study
#15
Matthew Detering, Elizabeth Steels, Sundar Rao Koyyalamudi, Elena Allifranchini, Elena Bocchietto, Luis Vitetta
A double-blind, randomized, placebo-controlled clinical trial assessed the efficacy and safety of Ageratum conyzoides in treating benign prostatic hypertrophy (BPH). In this study, 109 men with medically diagnosed BPH, aged 41-76 years, were administered the investigational product, A. conyzoides extract at a dose of 250 mg/d or placebo, q.d. for 12 weeks. The primary outcome measures were the International Prostate Symptom Score (IPSS), daily urinary frequency and safety evaluations. The secondary outcome measures were testosterone, dihydrotestosterone, oestradiol, sex hormone binding globulin (SHBG), Dehydroepiandrosterone sulfate (DHEA-S) and cortisol levels, and prostate specific antigen (PSA), lipids, blood glucose, the Aging Male's Symptom (AMS) Score and sexual function assessed by Derogatis Interview for Sexual Functioning-Self Report (DISF-SR)...
October 19, 2017: BioFactors
https://www.readbyqxmd.com/read/29044447/relationship-between-androgen-deficiency-and-memory-impairment-in-aging-and-alzheimer-8217-s-disease
#16
Graciela Jiménez-Rubio, José J Herrera-Pérez, Olivia T Hernández-Hernández, Lucía Martínez-Mota
Aging and Alzheimer’s disease (AD) are associated with a declination of cognition and memory, whose severity increases in AD. Recent investigations point to a greater participation of neurofibrillary tangles (NFTs) than that of senile plaques, as responsible for cognitive impairment in AD and normal aging. On the other hand, aging is related with reduced levels of dehydroepiandrosterone (DHEA) and its sulfate (DHEA-S) as well as testosterone (T). Basic and clinical studies give evidence that hypoandrogenism is associated with memory impairment...
September 2017: Actas Españolas de Psiquiatría
https://www.readbyqxmd.com/read/29030154/simultaneous-profiles-of-sulfonated-androgens-sulfonated-estrogens-and-sulfonated-progestogens-in-postpubertal-boars-sus-scrofa-domestica-measured-by-lc-ms-ms
#17
G Schuler, A Sánchez-Guijo, M F Hartmann, S A Wudy
Sulfonated steroids (s-St) have been usually regarded as inactive metabolites but are progressively considered as precursors for the intra-tissue formation of bioactive steroids. Moreover, independent effects without preceding removal of the sulfate group have been observed. We use the porcine testicular-epididymal compartment as a model to investigate the still largely unknown s-St physiology as the boar exhibits an intriguingly broad s-St spectrum predominantly originating from the testis. The application of LC-MS/MS in steroidomics enables the determination of unconjugated and intact sulfonated steroids with currently highest specificity and good sensitivity, allowing the concurrent measuring of numerous analytes in larger quantities of samples...
October 10, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28987899/plasma-lipoproteins-in-posttraumatic-stress-disorder-patients-compared-to-healthy-controls-and-their-associations-with-the-hpa-and-hpt-axis
#18
Giel-Jan de Vries, Roel Mocking, Johanna Assies, Aart Schene, Miranda Olff
BACKGROUND: Based on studies among primarily male veteran subjects, lipoproteins are thought to mediate the association of posttraumatic stress disorder (PTSD) with cardiovascular disease (CVD). However, recent civilian studies with female samples or samples with both sexes represented provide little evidence for this association. Gender, diet and sex-specific effects of stress hormones on lipoproteins may explain this dissociation in findings. METHOD: Cross-sectional analysis of plasma concentrations of total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL) and triglycerides (TG) in a male and female sample of 49 PTSD-patients due to civilian trauma and 45 healthy controls...
December 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28950181/cross-sectional-study-of-the-determinants-and-associations-of-sex-hormone-binding-globulin-concentrations-in-first-degree-relatives-fdr-of-patients-with-type-2-diabetes-mellitus
#19
N A Abdella, O A Mojiminiyi
AIMS: This study explores the determinants of sex hormone binding globulin (SHBG) and associations with categories of glucose intolerance and undiagnosed diabetes in first-degree relatives (FDR) of patients with Type 2 Diabetes Mellitus (T2D). METHODS: Anthropometric indices, fasting lipids, glucose, insulin, adiponectin, leptin, SHBG, estradiol (E2), testosterone (TT), androstenedione (AND), dehydroepiandrosterone sulphate (DHEA-S), high-sensitivity C-reactive protein (hs-CRP) and alanine aminotransferase (ALT) were measured in 584 FDR...
September 5, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28912337/adrenal-hyperandrogenism-does-not-deteriorate-insulin-resistance-and-lipid-profile-in-women-with-pcos
#20
Stavroula A Paschou, Eleni Palioura, Dimitrios Ioannidis, Panagiotis Anagnostis, Argyro Panagiotakou, Vasiliki Loi, Georgios Karageorgos, Dimitrios G Goulis, Andromachi Vryonidou
OBJECTIVE: The aim of this study was to investigate the impact of adrenal hyperandrogenism on insulin resistance and lipid profile in women with polycystic ovary syndrome (PCOS). PATIENTS AND METHODS: We studied 372 women with PCOS according to the NIH criteria. 232 age- and BMI-matched women served as controls in order to define adrenal hyperandrogenism (DHEA-S >95th percentile). Then, patients with PCOS were classified into two groups: with adrenal hyperandrogenism (PCOS-AH, n = 108) and without adrenal hyperandrogenism (PCOS-NAH, n = 264)...
November 2017: Endocrine Connections
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