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https://www.readbyqxmd.com/read/28157253/total-testosterone-to-dihydrotestosterone-ratio-assessed-by-lc-ms-ms-predicts-a-worse-metabolic-profile-not-only-in-pcos-patients
#1
Urszula Ambroziak, Alina Kuryłowicz, Anna Kępczyńska-Nyk, Zbigniew Bartoszewicz, Agnieszka Kondracka, Radosław Jaźwiec, Emilia Samborowska, Michał Dadlez, Aleksandra Wysłouch-Cieszyńska, Tomasz Bednarczuk
OBJECTIVES: Total testosterone/dihydrotestosterone ratio (TT/DHT) was found to determine metabolic risk in polycystic ovary syndrome (PCOS). The aim of this study was to analyze whether (TT/DHT) may be helpful in predicting metabolic risk not only in PCOS patients but also in healthy women. MATERIAL AND METHODS: Total testosterone (TT), dihydrotestosterone (DHT), androstendione and dehydroepiandrosterone sulphate (DHEA-S) were measured by LC-MS/MS in 36 women with PCOS and in 29 age-matched controls without clinical hyperandrogenism...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/28154797/sex-specific-effects-of-serum-sulfate-level-and-slc13a1-nonsense-variants-on-dhea-homeostasis
#2
Christina G Tise, Leslie E Anforth, Albert E Zhou, James A Perry, Patrick F McArdle, Elizabeth A Streeten, Alan R Shuldiner, Laura M Yerges-Armstrong
CONTEXT: Sulfate is critical in the biotransformation of multiple compounds via sulfation. These compounds include neurotransmitters, proteoglycans, xenobiotics, and hormones such as dehydroepiandrosterone (DHEA). Sulfation reactions are thought to be rate-limited by endogenous sulfate concentrations. The gene, SLC13A1, encodes the sodium-sulfate cotransporter NaS1, responsible for sulfate (re)absorption in the intestines and kidneys. We previously reported two rare, non-linked, nonsense variants in SLC13A1 (R12X and W48X) associated with hyposulfatemia (P = 9 × 10(- 20))...
March 2017: Molecular Genetics and Metabolism Reports
https://www.readbyqxmd.com/read/28117719/essential-oil-of-japanese-cedar-cryptomeria-japonica-wood-increases-salivary-dehydroepiandrosterone-sulfate-levels-after-monotonous-work
#3
Eri Matsubara, Yuko Tsunetsugu, Tatsuro Ohira, Masaki Sugiyama
Employee problems arising from mental illnesses have steadily increased and become a serious social problem in recent years. Wood is a widely available plant material, and knowledge of the psychophysiological effects of inhalation of woody volatile compounds has grown considerably. In this study, we established an experimental method to evaluate the effects of Japanese cedar wood essential oil on subjects performing monotonous work. Two experiment conditions, one with and another without diffusion of the essential oil were prepared...
January 21, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28110240/lead-exposure-is-related-to-hypercortisolemic-profiles-and-allostatic-load-in-brazilian-older-adults
#4
Juliana N Souza-Talarico, Deborah Suchecki, Robert-Paul Juster, Pierrich Plusquellec, Fernando Barbosa Junior, Vinícius Bunscheit, Tania Marcourakis, Tatiane Martins de Matos, Sonia J Lupien
Lead levels (Pb) have been linked to both hyper- and hypo-reactivity of hypothalamic-pituitary-adrenal axis (HPA) axis to acute stress in animals and humans. Similarly, allostatic load (AL), the 'wear and tear' of chronic stress, is associated with inadequate HPA axis activity. We examined whether Pb levels would be associated with altered diurnal cortisol profile, as a primary mediator of AL, during aging. Pb levels were measured from blood samples (BPb) of 126 Brazilian individuals (105 women), between 50 and 82 years old...
January 19, 2017: Environmental Research
https://www.readbyqxmd.com/read/28077245/a-systematic-review-of-adrenarche-as-a-sensitive-period-in-neurobiological-development-and-mental-health
#5
REVIEW
Michelle L Byrne, Sarah Whittle, Nandita Vijayakumar, Meg Dennison, Julian G Simmons, Nicholas B Allen
Substantial hormonal and neurobiological changes occur during puberty, and are widely argued to render this period of life a sensitive period in terms of risk for mental health problems. However, there is a paucity of research focusing on adrenarche, the earlier phase of pubertal development. Furthermore, there is a limited understanding of the association between adrenarche and neural development during this phase of life. We systematically reviewed research examining human adrenarcheal development as operationalized by hormonal levels of DHEA and DHEA-S, in relation to indices of mental health (Systematic Review 1)...
December 21, 2016: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/28071011/the-effects-of-a-low-calorie-diet-or-an-isocaloric-diet-combined-with-metformin-on-sex-hormones-in-obese-women-of-child-bearing-age
#6
RANDOMIZED CONTROLLED TRIAL
Ewelina Swora-Cwynar, Magdalena Kujawska-Łuczak, Joanna Suliburska, Julita Reguła, Angelika Kargulewicz, Matylda Kręgielska-Narożna, Emilia Marcinkowska, Alina Kanikowska, Marzena Bielas, Marian Grzymisławski, Paweł Bogdański
BACKGROUND: The influence of weight loss treatment on sex hormones profile has been studied mainly in women with polycystic ovary syndrome (PCOS), but in obese premenopausal women without PCOS it still remains unclear. The aim of the study was to evaluate the effect of two approaches to obesity treatment on the serum level of sex hormones in obese women of child-bearing age without PCOS. METHODS: 77 obese Caucasian women (aged 31.2 ±8.3 years) were randomized into two groups: 39 women received a low-calorie diet (LC) and 38 received an isocaloric diet plus metformin (IM), for 12 weeks...
April 2016: Acta Scientiarum Polonorum. Technologia Alimentaria
https://www.readbyqxmd.com/read/28038403/higher-serum-dhea-concentrations-before-and-after-ssri-treatment-are-associated-with-remission-of-major-depression
#7
Christina M Hough, Daniel Lindqvist, Elissa S Epel, Molly St Denis, Victor I Reus, F Saverio Bersani, Rebecca Rosser, Laura Mahan, Heather M Burke, Owen M Wolkowitz, Synthia H Mellon
BACKGROUND: Dehydroepiandrosterone (DHEA) and its sulfated ester DHEA-sulfate (DHEA-S), (together DHEA[S]), are the most abundant adrenal steroids in humans and are found in blood and the brain, where they function as neurosteroids with direct receptor affinities. Preclinical studies suggest that DHEA(S) has antidepressant/neuroprotective properties, and exogenously administered DHEA has shown antidepressant efficacy in humans. Nonetheless, the role of endogenous DHEA(S) levels in major depressive disorder (MDD) and antidepressant outcomes remains unclear...
December 5, 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28008861/delayed-diagnosis-of-a-17-hydroxylase-17-20-lyase-deficient-case-presented-with-46-xy-female-low-normal-potassium-can-alert-clinician
#8
Emine Çamtosun, Zeynep Şıklar, Serdar Ceylaner, Pınar Kocaay, Merih Berberoğlu
17-hydroxylase/17,20-lyase deficiency (17OHD) is a rare autosomal recessive defect in adrenal and gonadal steroidogenesis, causes absence of secondary sexual characteristics frequently associated with hypertension and hyperkalemia. Here we report a 46, XY case, who had normal potassium levels and without hypertension. Here we present a 2,5 years old female admitted with female external genitalia and inguinal swelling. Pathology of biopsy revealed that this gonad is a testis. Karyotype was 46, XY. She had no hypertension and no hypokalemia...
December 23, 2016: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/27937077/hypocholesterolemic-efficacy-of-royal-jelly-in-healthy-mild-hypercholesterolemic-adults
#9
Hui-Fang Chiu, Bo-Kai Chen, Yan-Ying Lu, Yi-Chun Han, You-Cheng Shen, Kamesh Venkatakrishnan, Oksana Golovinskaia, Chin-Kun Wang
CONTEXT: Royal jelly (RJ) has been reported for its health promoting factors such as antioxidant, anti-inflammatory and lipid lowering activities. OBJECTIVE: The present randomized, placebo-controlled study examines the hypolipidemic beneficial effect of RJ through evaluating anthropometric measurements, lipid profile and various hormone levels in mildly hypercholesterolemic participants. MATERIALS AND METHODS: Forty subjects with mild hypercholesterolemia (180-200 mg/dL) were randomly selected and divided into two groups as experimental or placebo, who requested to intake nine capsules (350 mg/capsule) of RJ or placebo/day, respectively, for three months with one month of follow-up without any supplementation...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27914864/serum-dhea-s-concentration-correlates-with-clinical-symptoms-and-neurocognitive-function-in-patients-with-bipolar-ii-disorder-a-case-controlled-study
#10
Sheng-Yu Lee, Liang-Jen Wang, Cheng-Ho Chang, Chih-Ching Wu, Hsing-Ling Chen, Shih-Hsien Lin, Chin-Liang Chu, Ti Lu, Ru-Band Lu
OBJECTIVES: Dysregulation of the neuroendocrine system including dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEA-S), and pregnenolone may play a role in the pathophysiology of bipolar II disorder (BP-II). The aims of the current study are to determine (a) the differences in DHEA, DHEA-S and pregnenolone in patients with BP-II and controls; and (b) the correlation of levels of the above hormones, cognitive function, and clinical symptoms. METHODS: Patients diagnosed with BP-II and healthy controls were recruited from psychiatric department...
March 6, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/27853073/feminizing-adrenocortical-carcinoma-with-distinct-histopathological-findings
#11
Masako Hatano, Yasuhiro Takenaka, Ikuo Inoue, Keiko Homma, Tomonobu Hasegawa, Hisanobu Sasano, Takuya Awata, Shigehiro Katayama
We herein present a 60-year-old man with adrenocortical carcinoma who had gynecomastia. An endocrinological examination revealed increased levels of serum estradiol and dehydroepiandrosterone-sulfate (DHEA-S) and reduced levels of free testosterone. Magnetic resonance imaging showed an adrenal tumor with heterogeneous intensity. Iodine-131 adosterol scintigraphy showed an increased uptake at the same site. Because feminizing adrenocortical carcinoma was suspected, right adrenalectomy was performed; the pathological diagnosis was adrenocortical carcinoma...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27799351/inflammation-immune-activation-immunosenescence-and-hormonal-biomarkers-in-the-frailty-related-phenotype-of-men-with-or-at-risk-for-hiv
#12
Kristine M Erlandson, Derek Ng, Lisa P Jacobson, Joseph B Margolick, Adrian S Dobs, Frank J Palella, Jordan E Lake, Hanhvy Bui, Lawrence Kingsley, Todd T Brown
BACKGROUND:  The extent to which inflammation, immune activation/immunosenescence, and hormonal abnormalities are driven by HIV or frailty is not clear. METHODS:  HIV-infected frail men (n=155) were matched to non-frail, HIV-infected (n=141) and HIV-uninfected (n=150) men by age, calendar year, and antiretroviral therapy (ART) use (HIV only). Frailty was defined by ≥3 frailty-related phenotype criteria (weight loss, exhaustion, low activity, slowness) at ≥2 visits, or at 1 visit with ≥1 criteria at ≥2 visits...
October 31, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27771624/non-androgen-secreting-adrenocortical-carcinoma-in-preadolescence-a-case-report-and-literature-review
#13
Hiroko Narumi, Shunji Hasegawa, Kazuyuki Waki, Ken Fukuda, Yuji Ohnishi, Takuya Ichimura, Yousuke Fujimoto, Shunsaku Katsura, Hiroo Kawano, Eiji Ikeda, Satoshi Okada, Shouichi Ohga
Adrenocortical carcinoma (ACC) is a rare malignancy in childhood. Affected children with ACC mostly present with virilization, but not the pure form of Cushing's syndrome. A 9-year-old Japanese girl was hospitalized, because of the unstable emotions and excessive weight gain. She was diagnosed as having Cushing's syndrome and a left adrenal tumor. The adrenalectomy led to the pathological diagnosis of ACC without metastasis. There was no mutation of PRKACA in the tumor-derived DNA, or p53 in peripheral blood-derived DNA...
November 1, 2016: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/27723553/the-evaluation-of-endothelial-function-and-structure-in-hirsute-patients-in-reproductive-age
#14
Kemal Atasayan, Tevfik Yoldemir, Sedef Ramoglu, Dilek Gogas Yavuz
OBJECTIVE: To evaluate the endothelial function and structure in patients with hirsutism in reproductive age. STUDY DESIGN: The study was conducted on 69 consecutive women admitted with complaints of hirsutism and 63 voluntary healthy women, as controls. A total of 132 subjects who applied to the Gynecology and Infertility Outpatient Clinics were included. Participants with modified Ferriman Gallway (mFG) score over 8 were considered to be hirsute. The demographic, metabolic, hormonal characteristics, risk factors of cardiovascular disease, CIMT (carotis intima media thickness) and FMD (flow-mediated dilatation) were compared between hirsute women and those in the control group...
November 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27652022/decrease-of-dhea-s-concentration-succeeding-a-micro-dose-thumb-exertion-mood-state-determinants-reflect-stress-biomarker-responses
#15
Adam Michael Szlezak, Lotti Tajouri, Siri Lauluten Szlezak, James Keane, Clare Minahan
BACKGROUND: The present study examined the effect of a micro-dose of resistance-exercise on serum DHEA-S, IL-6 and mood-state determinants. Potential relationships between mood and the biomarkers were also studied with the aim of directing research on non-invasive exercise-monitoring methods. METHODS: 30 male participants (20 weightlifting-trained; 10 untrained) were separated into 3 groups of 10: weightlifting experimental (WLEXP); untrained experimental (UTEXP); weightlifting placebo (WLPLA)...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27635134/myo-inositol-in-the-treatment-of-teenagers-affected-by-pcos
#16
Lali Pkhaladze, Ludmila Barbakadze, Nana Kvashilava
Objective. To compare the effectiveness of myo-inositol (MI) and oral contraceptive pills (OCPs) in monotherapy and MI in combination with OCPs in the treatment of teenagers affected by polycystic ovary syndrome (PCOS). Methods. 61 adolescent girls aged 13-19 years, with PCOS, were involved in the prospective, open-label study. Patients were randomized into three groups: I group, 20 patients receiving drospirenone 3 mg/ethinyl estradiol 30 μg; II group, 20 patients receiving 4 g myo-inositol plus 400 mg folic acid; III group, 21 patients receiving both medications...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/27623070/age-dependent-increases-in-adrenal-cytochrome-b5-and-serum-5-androstenediol-3-sulfate
#17
Juilee Rege, Shigehiro Karashima, Antonio M Lerario, Joshua M Smith, Richard J Auchus, Josephine Z Kasa-Vubu, Hironobu Sasano, Yasuhiro Nakamura, Perrin C White, William E Rainey
CONTEXT: Adrenal production of dehydroepiandrosterone sulfate (DHEA-S) increases throughout childhood owing to expansion of the zona reticularis (ZR). ZR features cells with a steroidogenic phenotype distinct from that of the adjacent zona fasciculata, with higher expression of cytochrome b5 type A (CYB5A) and steroid sulfotransferase type 2A1 but decreased 3β-hydroxysteroid dehydrogenase type 2 (HSD3B2). In addition to DHEA-S, three adrenal Δ5-steroid sulfates could provide additional tools to define adrenal maturation...
December 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27615264/the-effect-of-steroid-hormones-on-the-physical-performance-of-boys-and-girls-during-an-olympic-weightlifting-competition
#18
Blair Crewther, Zbigniew Obminski, Christian Cook
PURPOSE: To examine the steroid hormone effect on the physical performance of young athletes during an Olympic weightlifting competition. METHODS: 26 boys and 26 girls were monitored across 2 weightlifting competitions. Pre- and post-competition testosterone (T), cortisol (C) and dehydroepiandrosterone-sulfate (DHEA-s) were measured in blood, with pre-event free T (FT) and the free androgen index (FAI) calculated. Body mass (BM) and weightlifting performance were recorded...
November 2016: Pediatric Exercise Science
https://www.readbyqxmd.com/read/27545660/lower-body-weight-and-bmi-at-birth-were-associated-with-early-adiposity-rebound-in-21-hydroxylase-deficiency-patients
#19
Shigeru Takishima, Keisuke Nakajima, Risa Nomura, Atsumi Tsuji-Hosokawa, Nozomi Matsuda, Yohei Matsubara, Makoto Ono, Kentaro Miyai, Kei Takasawa, Tomohiro Morio, Yukihiro Hasegawa, Kenichi Kashimada
21-hydroxylase deficiency (21-OHD) is the most common type of congenital adrenal hyperplasia. In addition to the clinical problems caused by adrenal insufficiency and androgen excess, a risk for obesity and metabolic syndrome during young adulthood is a major ramification of the disease. Although glucocorticoid therapy is very likely to be one of the contributory factors, the precise causes of the metabolic status of adult 21-OHD patients remain to be clarified. Previously we reported that 21-OHD patients developed early onset AR, a condition which might create a risk for obesity and metabolic syndrome in adulthood...
November 30, 2016: Endocrine Journal
https://www.readbyqxmd.com/read/27531310/changes-in-dhea-s-levels-during-the-first-year-of-treatment-in-patients-with-clinical-burnout-are-related-to-health-development
#20
Anna-Karin Lennartsson, Töres Theorell, Mark M Kushnir, Ingibjörg H Jonsdottir
The regenerative hormone DHEA-S was measured in 122 patients with clinical burnout during their first year of treatment. Relations between change of DHEA-S levels and development in health were investigated. About half of the patients exhibited increased DHEA-S levels during the year, while the other half exhibited decreased levels. There was no difference in burnout symptoms or associated health status at baseline between subsequent DHEA-S increasing and DHEA-S decreasing groups. Greater reduction in the burnout symptoms was observed in patients in who DHEA-S levels increased during the year, than in the patients in who DHEA-S levels decreased...
October 2016: Biological Psychology
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