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https://www.readbyqxmd.com/read/28449564/dehydroepiandrosterone-sulfate-level-varies-nonlinearly-with-symptom-severity-in-major-depressive-disorder
#1
Dasom Uh, Hyun-Ghang Jeong, Kwang-Yeon Choi, So-Young Oh, Suji Lee, Seung-Hyun Kim, Sook-Haeng Joe
Objective: The pathophysiology of major depressive disorder (MDD) is still not well understood. Conflicting results for surrogate. biomarkers in MDD have been reported, which might be a consequence of the heterogeneity of MDD patients. Therefore, we aim to investigate how the severity of depression and various symptom domains are related to the levels of dehydroepiandrosterone sulfate (DHEA-s) in MDD patients. Methods: We recruited 117 subjects from a general practice...
May 31, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28438275/psychophysical-health-status-of-breast-cancer-survivors-and-effects-of-12-weeks-of-aerobic-training
#2
Andrea Di Blasio, Teresa Morano, Ettore Cianchetti, Sabina Gallina, Ines Bucci, Serena Di Santo, Camilla Tinari, Francesco Di Donato, Pascal Izzicupo, Angela Di Baldassarre, Alessandra Cimini, Giorgio Napolitano
The aim of this study was to analyse the health status of breast cancer survivors and the effects of 12 weeks of aerobic training. Twenty-three breast cancer survivors (51.71 ± 3.17 years) and 23 healthy women (50.73 ± 2.97 years) were investigated for body composition, daily physical activity, quality of life, salivary cortisol, and DHEA-S. Breast cancer survivors were then aerobically trained for 12 weeks. Breast cancer survivors have a worse psychophysical health than healthy women. Aerobic training increased salivary DHEA-S, aerobic fitness, self-reported health, and nocturnal sleeping time and reduced salivary cortisol in breast cancer survivors...
May 2017: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/28423014/initial-systemic-inflammatory-state-perturbs-exercise-training-adaptations-in-elite-taekwondo-athletes
#3
Chung-Yu Chen, Yi-Hung Liao, Chun-Chung Chou, Yu-Chi Sung, Shiow-Chwen Tsai
PURPOSE: This study examined ten-week TKD-specific training effects on aerobic capacity, body composition, hormone responses and hematological parameters in elite TKD athletes with varied initial inflammatory states. METHODS: Twenty-two elite college TKD athletes were divided into two groups according to their initial neutrophils-to-lymphocytes ratio (NLR) values: Low NLR (N = 11, 9M/2F, age: 21.6 ± 1.0 yrs; NLR: 1.3 ± 0.2) and High NLR (N = 11, 8M/3F, age: 22...
2017: PloS One
https://www.readbyqxmd.com/read/28401652/the-role-of-dehydroepiandrosterone-on-functional-innate-immune-responses-to-acute-stress
#4
Sean P Prall, Emilee E Larson, Michael P Muehlenbein
The androgen dehydroepiandrosterone (DHEA) responds to stress activation, exhibits anti-glucocorticoid properties, and modulates immunity in diverse ways, yet little is known of its role in acute stress responses. In this study, the effects of DHEA and its sulfate ester DHEA-S on human male immune function during exposure to an acute stressor is explored. Variation in DHEA, DHEA-S, testosterone, and cortisol, along with bacterial killing assays, was measured in response to a modified Trier Social Stress test in 27 young adult males...
April 11, 2017: Stress and Health: Journal of the International Society for the Investigation of Stress
https://www.readbyqxmd.com/read/28376482/discordant-genotypic-sex-and-phenotype-variations-in-two-spanish-siblings-with-17%C3%AE-hydroxylase-17-20-lyase-deficiency-carrying-the-most-prevalent-mutated-cyp17a1-alleles-of-brazilian-patients
#5
Mónica Fernández-Cancio, Emilio García-García, Carmen González-Cejudo, María-Angeles Martínez-Maestre, Miguel-Angel Mangas-Cruz, Gil Guerra-Junior, Maricilda Pandi de Mello, Ivo J P Arnhold, Mirian Y Nishi, Berenice Bilharinho Mendonça, Elena García-Arumí, Laura Audí, Eduardo Tizzano, Antonio Carrascosa
17α-hydroxylase/17,20-lyase deficiency is a rare form of congenital adrenal hyperplasia caused by mutations in CYP17A1. Two phenotypic female sisters, aged 17 and 15 years and with 46,XY and 46,XX karyotypes, respectively, presented with primary amenorrhea and absent secondary sexual characteristics. The elder sib also presented with high blood pressure. Both patients had elevated levels of ACTH, gonadotropins, progesterone, corticosterone, and deoxycorticosterone, and reduced levels of estradiol, testosterone, androstenedione, 17-OH-P, DHEA-S, cortisol, aldosterone, and renin activity...
April 4, 2017: Sexual Development: Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation
https://www.readbyqxmd.com/read/28373267/longitudinal-analyses-of-the-steroid-metabolome-in-obese-pcos-girls-with-weight-loss
#6
Thomas Reinehr, Alexandra Kulle, Juliane Rothermel, Caroline Knop, Nina Lass, Christina Bosse, Paul-Martin Holterhus
OBJECTIVE: The underlying mechanisms of polycystic ovarian syndrome (PCOS) are not fully understood yet. The aim of the study was to get functional insights into the regulation of steroid hormones in PCOS by steroid metabolomics. DESIGN: This is a longitudinal study of changes of steroid hormones in 40 obese girls aged 13-16 years (50% with PCOS) participating in a 1-year lifestyle intervention. Girls with and without PCOS were matched to age, BMI, and change of weight status...
April 3, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28367959/polymorphisms-of-sts-gene-and-sult2a1-gene-and-neurosteroid-levels-in-han-chinese-boys-with-attention-deficit-hyperactivity-disorder-an-exploratory-investigation
#7
Liang-Jen Wang, Wen-Ching Chan, Miao-Chun Chou, Wen-Jiun Chou, Min-Jing Lee, Sheng-Yu Lee, Pao-Yen Lin, Yi-Hsin Yang, Cheng-Fang Yen
This study examined the relationships among polymorphisms of the STS gene and SULT2A1 gene, dehydroepiandrosterone (DHEA) and its sulfated form (DHEA-S), and characteristics of attention-deficit/hyperactivity disorder (ADHD). We used cheek swabs to obtain the genomic DNA of 200 ADHD male probands (mean age: 8.7 years), 192 patients' mothers and 157 patients' fathers. Three SNPs in the STS gene (rs6639786, rs2270112, and rs17268988) and one SNP in the SULT2A1 gene (rs182420) were genotyped. Saliva samples were collected from the ADHD patients to analyze DHEA and DHEA-S levels...
April 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28335515/dehydroepiandrosterone-dhea-feeding-protects-liver-steatosis-in-obese-breast-cancer-rat-model
#8
Reza Hakkak, Andrea Bell, Soheila Korourian
Obesity is a major health problem in the US and globally. Obesity is associated with the risk of cardiovascular disease, type 2 diabetes, cancers, hyperlipidemia, and liver steatosis development. Dehydroepiandrosterone (DHEA) is a dietary supplement used as an anti-obesity supplement. Previously, we reported that DHEA feeding protects 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary tumors. The objectives of this study were to investigate the effects of obesity and DHEA feeding on liver steatosis, body weight gain, and serum DHEA, DHEA sulfate (DHEA-S), insulin-like growth factor-1 (IGF-1), and insulin-like growth factor binding protein-3 (IGFBP-3) levels...
March 20, 2017: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/28328386/walking-training-and-cortisol-to-dhea-s-ratio-in-postmenopause-an-intervention-study
#9
Andrea Di Blasio, Pascal Izzicupo, Angela Di Baldassarre, Sabina Gallina, Ines Bucci, Cesidio Giuliani, Serena Di Santo, Angelo Di Iorio, Patrizio Ripari, Giorgio Napolitano
The literature indicates that the plasma cortisol-to-dehydroepiandrosterone-sulfate (DHEA-S) ratio is a marker of health status after menopause, when a decline in both estrogen and DHEA-S and an increase in cortisol occur. An increase in the cortisol-to-DHEA-S ratio has been positively correlated with metabolic syndrome, all-cause mortality, cancer, and other diseases. The aim of this study was to investigate the effects of a walking program on the plasma cortisol-to-DHEA-S ratio in postmenopausal women. Fifty-one postmenopausal women participated in a 13-week supervised walking program, in the metropolitan area of Pescara (Italy), from June to September 2013...
March 22, 2017: Women & Health
https://www.readbyqxmd.com/read/28326299/the-association-between-dehydroepiandrosterone-sulfate-dhea-s-and-bone-mineral-density-in-korean-men-and-women
#10
Seung-Gun Park, Sena Hwang, Jong-Suk Kim, Kyung-Chae Park, Yuri Kwon, Kyong-Chol Kim
BACKGROUND: The relationship between dehydroepiandrosterone sulfate (DHEA-S) and bone mineral density (BMD) is controversial. And findings of most studies that have investigated this relationship are restricted to postmenopausal women. In this study, we investigated the relationship between serum DHEA-S and BMD in both men and women. METHODS: This cross-sectional study evaluated a total of 294 healthy Korean participants through a medical examination program. And a subgroup of 154 participants was subjected to a longitudinal analysis...
February 2017: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/28319688/attenuated-dhea-and-dhea-s-response-to-acute-psychosocial-stress-in-individuals-with-depressive-disorders
#11
Xiaoling Jiang, Wen Zhong, Haiyan An, Mingyu Fu, Yuanyuan Chen, Zhenggang Zhang, Zhongju Xiao
BACKGROUND: In recent years, a relationship between depression and basal dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) levels has frequently been suggested, but responses of these adrenal steroids to psychosocial stress have not been examined in individuals with depressive disorders. In this study, we examined salivary DHEA, DHEA-S, and cortisol/DHEA response to the Trier Social Stress Test (TSST) in individuals with depressive disorders and in healthy controls to discover whether the responses of DHEA and DHEA-S to acute psychosocial stress could be a more sensitive marker of HPA dysfunction in depressive disorders...
March 16, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28300464/serum-visfatin-vascular-endothelial-growth-factor-and-matrix-metalloproteinase-9-in-women-with-polycystic-ovary-syndrome
#12
Kalliopi Dambala, Dimitrios Vavilis, Eleni Bili, Dimitrios G Goulis, Basil C Tarlatzis
AIM: To evaluate serum concentrations of visfatin, vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) in women with polycystic ovary syndrome (PCOS) and to investigate their possible role as early endothelial markers in PCOS. METHODS: Forty-two women with PCOS and 42 controls, matched for age and weight, were included in the study. Serum concentrations of follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin, total testosterone (tT), Δ4-androstenedione (Δ4A), dehydroepinadrosterone sulphate (DHEA-S), 17-OH-progesterone, sex hormone-binding protein (SHBG), thyroid-stimulating hormone (TSH), free thyroxine (fT4), visfatin, VEGF and MMP-9 were measured in all women; free androgen index (FAI) was calculated as well...
March 16, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28229578/growth-and-pubertal-development-in-adolescent-male-wrestlers
#13
İbrahim E Pişkin, Mustafa Gümüş, Taner Bayraktaroğlu, Tevfik C Akalin, Faruk Yamaner
BACKGROUND: Adolescence is a crucial period for linear growth, and sports training during this time may have positive or negative effects on some physiological processes as growth. The purpose of this study was to evaluate the effects of intense training during somatic growth on the onset of puberty and growth development in adolescent wrestlers. METHODS: Fifty adolescent male wrestlers and twenty-one sedentary healthy male controls aged between 13-15 years were selected...
February 22, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28229260/dehydroepiandrosterone-sulfate-dhea-s-sex-and-age-in-zoo-housed-western-lowland-gorillas-gorilla-gorilla-gorilla
#14
Ashley N Edes
Among humans, dehydroepiandrosterone-sulfate (DHEA-S) declines with age and is hypothesized to be involved in somatic maintenance and healthy aging. Men have significantly higher DHEA-S than women, contradicting longer lifespans in the latter. Declines of DHEA-S with age also are observed in chimpanzees. In both chimpanzees and bonobos, males and females show no differences in DHEA-S production. Based on human and chimpanzee data, gorillas were predicted to show declining DHEA-S with age. Similar to chimpanzees and bonobos, it also was predicted DHEA-S would not be significantly different between males and females...
February 22, 2017: Primates; Journal of Primatology
https://www.readbyqxmd.com/read/28157253/total-testosterone-to-dihydrotestosterone-ratio-assessed-by-lc-ms-ms-predicts-a-worse-metabolic-profile-not-only-in-pcos-patients
#15
Urszula Ambroziak, Alina Kuryłowicz, Anna Kępczyńska-Nyk, Zbigniew Bartoszewicz, Agnieszka Kondracka, Radosław Jaźwiec, Emilia Samborowska, Michał Dadlez, Aleksandra Wysłouch-Cieszyńska, Tomasz Bednarczuk
OBJECTIVES: Total testosterone/dihydrotestosterone ratio (TT/DHT) was found to determine metabolic risk in polycystic ovary syndrome (PCOS). The aim of this study was to analyze whether (TT/DHT) may be helpful in predicting metabolic risk not only in PCOS patients but also in healthy women. MATERIAL AND METHODS: Total testosterone (TT), dihydrotestosterone (DHT), androstendione and dehydroepiandrosterone sulphate (DHEA-S) were measured by LC-MS/MS in 36 women with PCOS and in 29 age-matched controls without clinical hyperandrogenism...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/28154797/sex-specific-effects-of-serum-sulfate-level-and-slc13a1-nonsense-variants-on-dhea-homeostasis
#16
Christina G Tise, Leslie E Anforth, Albert E Zhou, James A Perry, Patrick F McArdle, Elizabeth A Streeten, Alan R Shuldiner, Laura M Yerges-Armstrong
CONTEXT: Sulfate is critical in the biotransformation of multiple compounds via sulfation. These compounds include neurotransmitters, proteoglycans, xenobiotics, and hormones such as dehydroepiandrosterone (DHEA). Sulfation reactions are thought to be rate-limited by endogenous sulfate concentrations. The gene, SLC13A1, encodes the sodium-sulfate cotransporter NaS1, responsible for sulfate (re)absorption in the intestines and kidneys. We previously reported two rare, non-linked, nonsense variants in SLC13A1 (R12X and W48X) associated with hyposulfatemia (P = 9 × 10(- 20))...
March 2017: Molecular Genetics and Metabolism Reports
https://www.readbyqxmd.com/read/28117719/essential-oil-of-japanese-cedar-cryptomeria-japonica-wood-increases-salivary-dehydroepiandrosterone-sulfate-levels-after-monotonous-work
#17
Eri Matsubara, Yuko Tsunetsugu, Tatsuro Ohira, Masaki Sugiyama
Employee problems arising from mental illnesses have steadily increased and become a serious social problem in recent years. Wood is a widely available plant material, and knowledge of the psychophysiological effects of inhalation of woody volatile compounds has grown considerably. In this study, we established an experimental method to evaluate the effects of Japanese cedar wood essential oil on subjects performing monotonous work. Two experiment conditions, one with and another without diffusion of the essential oil were prepared...
January 21, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28110240/lead-exposure-is-related-to-hypercortisolemic-profiles-and-allostatic-load-in-brazilian-older-adults
#18
Juliana N Souza-Talarico, Deborah Suchecki, Robert-Paul Juster, Pierrich Plusquellec, Fernando Barbosa Junior, Vinícius Bunscheit, Tania Marcourakis, Tatiane Martins de Matos, Sonia J Lupien
Lead levels (Pb) have been linked to both hyper- and hypo-reactivity of hypothalamic-pituitary-adrenal axis (HPA) axis to acute stress in animals and humans. Similarly, allostatic load (AL), the 'wear and tear' of chronic stress, is associated with inadequate HPA axis activity. We examined whether Pb levels would be associated with altered diurnal cortisol profile, as a primary mediator of AL, during aging. Pb levels were measured from blood samples (BPb) of 126 Brazilian individuals (105 women), between 50 and 82 years old...
April 2017: Environmental Research
https://www.readbyqxmd.com/read/28077245/a-systematic-review-of-adrenarche-as-a-sensitive-period-in-neurobiological-development-and-mental-health
#19
REVIEW
Michelle L Byrne, Sarah Whittle, Nandita Vijayakumar, Meg Dennison, Julian G Simmons, Nicholas B Allen
Substantial hormonal and neurobiological changes occur during puberty, and are widely argued to render this period of life a sensitive period in terms of risk for mental health problems. However, there is a paucity of research focusing on adrenarche, the earlier phase of pubertal development. Furthermore, there is a limited understanding of the association between adrenarche and neural development during this phase of life. We systematically reviewed research examining human adrenarcheal development as operationalized by hormonal levels of DHEA and DHEA-S, in relation to indices of mental health (Systematic Review 1)...
December 21, 2016: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/28071011/the-effects-of-a-low-calorie-diet-or-an-isocaloric-diet-combined-with-metformin-on-sex-hormones-in-obese-women-of-child-bearing-age
#20
RANDOMIZED CONTROLLED TRIAL
Ewelina Swora-Cwynar, Magdalena Kujawska-Łuczak, Joanna Suliburska, Julita Reguła, Angelika Kargulewicz, Matylda Kręgielska-Narożna, Emilia Marcinkowska, Alina Kanikowska, Marzena Bielas, Marian Grzymisławski, Paweł Bogdański
BACKGROUND: The influence of weight loss treatment on sex hormones profile has been studied mainly in women with polycystic ovary syndrome (PCOS), but in obese premenopausal women without PCOS it still remains unclear. The aim of the study was to evaluate the effect of two approaches to obesity treatment on the serum level of sex hormones in obese women of child-bearing age without PCOS. METHODS: 77 obese Caucasian women (aged 31.2 ±8.3 years) were randomized into two groups: 39 women received a low-calorie diet (LC) and 38 received an isocaloric diet plus metformin (IM), for 12 weeks...
April 2016: Acta Scientiarum Polonorum. Technologia Alimentaria
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