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https://www.readbyqxmd.com/read/29439180/secondary-neoplasms-of-the-female-lower-genital-tract-after-hematopoietic-cell-transplantation
#1
REVIEW
Howard A Chang, Saro H Armenian, Thanh H Dellinger
Hematopoietic cell transplantation (HCT) results in long-term survival (≥10 years) in 85% of patients who survive transplant-related complications within the first 2 years posttransplant. Transplant survivors, however, are at an increased risk of chronic health conditions compared with the general population, including the emergence of secondary malignant neoplasms. In particular, female transplant survivors may face a greater risk of lower genital tract (cervical, vulvar, or vaginal) neoplasms due to chronic immune dysregulation in the peritransplant and posttransplant environment...
February 2018: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29434259/three-dimensional-ultrastructural-analysis-of-the-interface-between-an-implanted-demineralised-dentin-matrix-and-the-surrounding-newly-formed-bone
#2
Ryuichiro Tanoue, Keisuke Ohta, Yoshihiro Miyazono, Joe Iwanaga, Akihiro Koba, Toru Natori, Osamu Iwamoto, Kei-Ichiro Nakamura, Jingo Kusukawa
Previous investigators have reported that transplanted demineralised dentin matrix (DDM) influences bone formation in vivo. However, the specific mechanism of how dentinal tubules contribute to bone formation has not been determined with regard to DDM transplantation therapy. In this study, we ultrastructurally investigated how DDM contacted the surrounding newly formed bone using a scanning electron microscopy (SEM) three-dimensional reconstruction method that is based on focused ion beam slicing and SEM (FIB/SEM)...
February 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29430228/routine-treatment-resistant-clostridium-difficile-infection-during-recovery-from-myxedema
#3
Jan K Adamski, Björn B Jäschke, Raija S Uusitalo-Seppälä, Kalle V J Moilanen, Antti V Pehkonen, Wojciech Weigl
Development of the extreme form of hypothyroidism defined as myxedema is very rare. Acute symptoms and their management have been described in detail previously. However, not much attention has been devoted to therapeutic challenges that are faced in the recovery phase of the treatment, especially pertaining to the gastrointestinal system. The link between myxedema and the appearance of severe Clostridium difficile infection (CDI) has not been established so far. A 61-year-old woman with no significant medical record was admitted to hospital because of infected heel pressure and thyroid dysfunction...
September 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/29429468/-research-advances-in-necrotizing-enterocolitis-in-neonates
#4
Xin Gan, Juan Li
Necrotizing enterocolitis (NEC) is a catastrophic disease caused by a variety of factors in neonates, especially preterm infants. Severe NEC has a high fatality rate, and most survivors may face short- and long-term adverse prognosis. Risk factors for NEC include preterm birth, non-breastfeeding, microbial abnormalities in the digestive tract, and ischemia-reperfusion injury. High-resolution abdominal ultrasound helps with the early diagnosis of NEC. The preventive measures for NEC include protecting the intestinal mucosa through nutritional intervention, interfering with intestinal injury signals, changing intestinal microflora, and performing early minimal enteral nutrition...
February 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29424411/-blastic-plasmacytoid-dendritic-cell-neoplasm-report-of-three-cases
#5
Alejandro Avilés-Salas, Myrna Candelaria, Mayra Ponce, Abraham Cañavera-Constantino, Sebastián Burgos
Blastic plasmacytoid dendritic cell neoplasm is a rare hematological malignancy derived from immature plasmacytoid dendritic cells. The tumor cells have an immature blastic appearance, and diagnosis is based on the expression of CD4, CD56 y CD123 in the absence of other lymphoid, natural killer, or myeloid antigens. The majority of affected individuals are older people with a mean age of 66 years. Male to female ratio is approximately 3:1. Common presentation includes cutaneous lesions followed by tumor dissemination...
September 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/29421860/-face-transplantation-current-status-and-future-developments
#6
REVIEW
Sotirios Tasigiorgos, Branislav Kollar, Nicco Krezdorn, Ericka M Bueno, Stefan G Tullius, Bohdan Pomahac
More than thirty-five facial allograft transplantations (FAT) have been reported worldwide since the pioneering case performed in France in the year 2005. FAT has received tremendous interest by the medical field and the general public while gaining strong support from multiple disciplines as a solution for reconstructing complex facial defects not amenable/responsive to conventional methods. FAT has expanded the frontiers of reconstructive microsurgery, immunology and transplantation, and established its place in the cross section of multiple disciplines...
February 8, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29421758/combining-spectroscopic-techniques-and-chemometrics-for-the-interpretation-of-lichen-biomonitoring-of-air-pollution
#7
P Malaspina, M Casale, C Malegori, M Hooshyari, M Di Carro, E Magi, P Giordani
A screening evaluation of lichen thalli, based on spectroscopic techniques coupled with chemometrics, is proposed as fast, simple and "green" method for the biomonitoring of air pollution. For two consecutive years, lichen thalli of Pseudevernia furfuracea were exposed for three months in selected sites of Liguria (NW-Italy) according to different levels and types of air pollution. At the end of the exposure period, transplanted thalli were analyzed by a set of monitoring techniques, including Front-Face Fluorescence Spectroscopy (FFFS), Near Infrared Spectroscopy (NIRS) and Plant Efficiency Analyser (PEA)...
February 3, 2018: Chemosphere
https://www.readbyqxmd.com/read/29414870/delivery-of-mesenchymal-stem-cells-from-gelatin-alginate-hydrogels-to-stomach-lumen-for-treatment-of-gastroparesis
#8
Binata Joddar, Nishat Tasnim, Vikram Thakur, Alok Kumar, Richard W McCallum, Munmun Chattopadhyay
Gastroparesis (GP) is associated with depletion of interstitial cells of Cajal (ICCs) and enteric neurons, which leads to pyloric dysfunction followed by severe nausea, vomiting and delayed gastric emptying. Regenerating these fundamental structures with mesenchymal stem cell (MSC) therapy would be helpful to restore gastric function in GP. MSCs have been successfully used in animal models of other gastrointestinal (GI) diseases, including colitis. However, no study has been performed with these cells on GP animals...
February 7, 2018: Bioengineering
https://www.readbyqxmd.com/read/29407331/safety-and-efficacy-of-induction-therapy-with-thymoglobulin-in-ab0-incompatible-kidney-transplantation
#9
A L Herzog, C Kalogirou, C Wanner, K Lopau
INTRODUCTION: Data suggest an additional role of T cells in antibody-mediated rejections. In 2001 a protocol for AB0-incompatible kidney transplantation based on B-cell-depleting anti-CD20 antibody rituximab, antigen-specific blood group IgG immunoadsorption, intravenous immunoglobulins, and triple immunosuppression was introduced in Europe, which used induction therapy with the use of interleukin-2 receptor antibody (IL2-RA) basiliximab. We used thymoglobulin in AB0-incompatible patients as induction in the face of high immunologic risk...
January 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29407314/multimodal-surgical-approach-for-adult-patients-with-chronic-intestinal-pseudo-obstruction-clinical-and-psychosocial-long-term-outcomes
#10
A Lauro, A D Pinna, E Tossani, V Stanghellini, M Manno, G Caio, L Golfieri, C Zanfi, N Cautero, A Bagni, U Volta, M Di Simone, L Pironi, R F Cogliandro, M Serra, A Venturoli, S Grandi, R De Giorgio
BACKGROUND: Clinical and psychosocial outcomes of a multimodal surgical approach for chronic intestinal pseudo-obstruction were analyzed in 24 patients who were followed over a 2- to 12-year period in a single center after surgery or intestinal/multivisceral transplant (CTx). METHODS: The main reasons for surgery were sub-occlusion in surgery and parenteral nutrition-related irreversible complications with chronic intestinal failure in CTx. RESULTS: At the end of follow-up (February 2015), 45...
January 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29398281/neurocognitive-outcomes-after-heart-transplantation-in-early-childhood
#11
Simon Urschel, Gwen Y Bond, Irina A Dinu, Fahime Moradi, Jennifer Conway, Gonzalo Garcia-Guerra, Bryan V Acton, Ari R Joffe, Mohammed AlAklabi, Ivan M Rebeyka, Charlene M T Robertson
BACKGROUND: Children requiring heart transplantation (HTx) for congenital heart disease (CHD) or failing anatomically normal hearts (CMP) face different challenges pre-HTx. We compared the neurocognitive capabilities in pre-school-age children receiving HTx for CHD vs CMP and determined factors predicting outcomes. METHODS: Data were collected within a prospective multi-provincial project from children who underwent HTx ≤4 years of age between 1999 and 2011. At age 54 ± 3 months, we obtained scores from the Wechsler Preschool and Primary Scales of Intelligence for full-scale intelligence quotient (FSIQ) verbal intelligence quotient (VIQ) and performance intelligence quotient (PIQ), and from the Beery-Buktenica Developmental Test for visual-motor integration (VMI)...
December 20, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29391754/use-of-direct-acting-antiviral-agents-in-hepatitis-c-virus-infected-liver-transplant-candidates
#12
REVIEW
Chiranjeevi Gadiparthi, George Cholankeril, Brandon J Perumpail, Eric R Yoo, Sanjaya K Satapathy, Satheesh Nair, Aijaz Ahmed
Since the advent of direct acting antiviral (DAA) agents, chronic hepatitis C virus (HCV) treatment has evolved at a rapid pace. In contrast to prior regimen involving ribavirin and pegylated interferon, these newer agents are highly effective, well-tolerated, have shorter course of therapy and safer essentially in all HCV patients including those with advanced liver disease and following liver transplantation. Clinicians caring for HCV-infected patients on the liver transplant (LT) waitlist are often faced with a dilemma whether to treat HCV infection before or after liver transplantation...
January 21, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29389822/management-of-intestinal-failure-in-middle-income-countries-for-children-and-adults
#13
Gabriel E Gondolesi, Francisco Pattín, Hamed Nikkoupur
PURPOSE OF REVIEW: Intestinal failure is a life-threatening medical condition that remains as a rare or orphan disease in most countries. The prevalence of intestinal failure and the therapeutic options available in middle-income countries (MIC) remain unclear. We aim to provide an overview on the current differences in management of intestinal failure patients in MIC from Latin America and Asia. RECENT FINDINGS: In order to fulfil the challenge, and after facing the difficulties of going over a topic with scarce available data, from countries with an extreme variety of social and economic problems, which are closely related to the treatment of intestinal failure patients, we have used both the existing publications and personal surveys to draft this document...
January 30, 2018: Current Opinion in Organ Transplantation
https://www.readbyqxmd.com/read/29381613/trismus-in-face-transplantation-following-ballistic-trauma
#14
Nicco Krezdorn, Muayyad Alhefzi, Bridget Perry, Mario A Aycart, Sotirios Tasigiorgos, Ericka M Bueno, Jordan R Green, Julian J Pribaz, Bohdan Pomahac, Edward J Caterson
BACKGROUND: Trismus can be a challenging consequence of ballistic trauma to the face, and has rarely been described in the setting of face transplantation. Almost half of all current face transplant recipients in the world received transplantation to restore form and function after a ballistic injury. Here we report our experience and challenges with long standing trismus after face transplantation. METHODS: We reviewed the medical records of our face transplant recipients whose indication was ballistic injury...
January 29, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29380554/did-parents-have-it-right-all-along-parents-risk-and-living-kidney-donation-revisiting-the-arguments-for-and-against-parental-living-donation-of-kidneys
#15
M A Freeman, A G Wightman
Historically, living kidney donation has been justified in part by our belief that living donors face minimal risks of subsequent disease. Recent research has brought that presumption into question, particularly for younger donors including parents. In light of this finding, we re-examine many of the traditional arguments both for and against the practice of parental living kidney donation. We then propose an alternative framework in which the burden of having a child with end-stage kidney disease can be considered as an illness experienced by the potential donor parent...
January 30, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29377992/genetic-and-epigenetic-factors-which-modulate-differentiation-propensity-in-human-pluripotent-stem-cells
#16
Alexander Keller, Dominika Dziedzicka, Filippo Zambelli, Christina Markouli, Karen Sermon, Claudia Spits, Mieke Geens
BACKGROUND: Human pluripotent stem cell (hPSC) lines are known to have a bias in their differentiation. This gives individual cell lines a propensity to preferentially differentiate towards one germ layer or cell type over others. Chromosomal aberrations, mitochondrial mutations, genetic diversity and epigenetic variance are the main drivers of this phenomenon, and can lead to a wide range of phenotypes. OBJECTIVE AND RATIONALE: Our aim is to provide a comprehensive overview of the different factors which influence differentiation propensity...
January 25, 2018: Human Reproduction Update
https://www.readbyqxmd.com/read/29377568/recent-advances-of-flexible-data-storage-devices-based-on-organic-nanoscaled-materials
#17
REVIEW
Li Zhou, Jingyu Mao, Yi Ren, Su-Ting Han, Vellaisamy A L Roy, Ye Zhou
Following the trend of miniaturization as per Moore's law, and facing the strong demand of next-generation electronic devices that should be highly portable, wearable, transplantable, and lightweight, growing endeavors have been made to develop novel flexible data storage devices possessing nonvolatile ability, high-density storage, high-switching speed, and reliable endurance properties. Nonvolatile organic data storage devices including memory devices on the basis of floating-gate, charge-trapping, and ferroelectric architectures, as well as organic resistive memory are believed to be favorable candidates for future data storage applications...
January 29, 2018: Small
https://www.readbyqxmd.com/read/29376095/massive-cortical-reorganization-is-reversible-following-bilateral-transplants-of-the-hands-evidence-from-the-first-successful-bilateral-pediatric-hand-transplant-patient
#18
William Gaetz, Sudha K Kessler, Tim P L Roberts, Jeffrey I Berman, Todd J Levy, Michelle Hsia, Deborah Humpl, Erin S Schwartz, Sandra Amaral, Ben Chang, Lawrence Scott Levin
In this repeated measures case study, we show that sensory deafferentation after limb amputation leads to changes in cortical somatotopic maps which are reversible after restoration of sensory input. Using magnetoencephalography (MEG), we observed in a child with bilateral hand transplants large-scale shifts in somatosensory lip cortical representation from anatomic hand area to anatomic face region. After recovery of tactile sensation in the digits, responses to finger stimulation were localized to orthotopic sensory cortex, but with atypical electrophysiologic features (amplitude and frequencies)...
January 2018: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29374030/microbiome-structure-influences-infection-by-the-parasite-crithidia-bombi-in-bumble-bees
#19
Blair K Mockler, Waldan K Kwong, Nancy A Moran, Hauke Koch
Recent declines in bumble bee populations are of great concern, and have prompted critical evaluations of the role of pathogen introductions and host resistance in bee health. One factor that may influence host resilience when facing infection is the gut microbiota. Previous experiments with Bombus terrestris, a European bumble bee, showed that the gut microbiota can protect against Crithidia bombi, a widespread trypanosomatid parasite of bumble bees. However, the particular characteristics of the microbiome responsible for this protective effect have thus far eluded identification...
January 26, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29373673/a-17-year-old-boy-with-right-face-palsy-left-leg-weakness-and-lytic-skull-bone-lesions
#20
Ibukunoluwa C Akinboyo, Genevieve M Crane, Lingling Chen, Ravit Arav-Boger
Human T-cell lymphotropic virus (HTLV), an infection that is endemic in certain parts of Asia, Africa, and South America, has been associated with malignancy and neurological deficits. Here, we describe a pediatric patient with chronic HTLV-I infection who developed complications associated with HTLV-I (ie, adult T-cell leukemia/lymphoma and HTLV-I-associated myelopathy/tropical spastic paraparesis). To our knowledge, this presentation in a child has never been described. The patient underwent a bone marrow transplant and, at the time of this writing, was in remission...
January 24, 2018: Journal of the Pediatric Infectious Diseases Society
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