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https://www.readbyqxmd.com/read/28207634/ethnic-background-is-a-potential-barrier-to-living-donor-kidney-transplantation-in-canada-a-single-center-retrospective-cohort-study
#1
Istvan Mucsi, Aarushi Bansal, Olusegun Famure, Yanhong Li, Margot Mitchell, Amy D Waterman, Marta Novak, S Joseph Kim
BACKGROUND: We examined if African or Asian ethnicity was associated with lower access to kidney transplantation (KT) in a Canadian setting. METHODS: Patients referred for KT to the Toronto General Hospital from January 1, 2003 to December 31, 2012, who completed social work assessment, were included (n=1769). The association between ethnicity and the time from referral to completion of KT evaluation or receipt of a KT were examined using Cox proportional hazards models...
February 15, 2017: Transplantation
https://www.readbyqxmd.com/read/28203596/intra-articular-implantation-of-mesenchymal-stem-cells-part-2-a-review-of-the-literature-for-meniscal-regeneration
#2
Matthew J Kraeutler, Justin J Mitchell, Jorge Chahla, Eric C McCarty, Cecilia Pascual-Garrido
Knee osteoarthritis (OA) after partial or total meniscectomy is a prevalent issue that patients must face. Various methods of replacing meniscal tissue have been studied to avoid this progression, including meniscal allograft transplantation, meniscal scaffolds, and synthetic meniscus replacement. Studies have shown that meniscal scaffolds may improve symptoms but have not been shown to prevent progression of OA. Recently, mesenchymal stem cells (MSCs) have been proposed as a possible biological therapy for meniscal regeneration...
January 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28196282/phosphatidylethanol-peth-detects-moderate-to-heavy-alcohol-use-in-liver-transplant-recipients
#3
Michael Francis Fleming, Matthew J Smith, Erika Oslakovic, Michael R Lucey, Jenny X Vue, Patrice Al-Saden, Josh Levitsky
BACKGROUND: Alcohol dependent liver transplantation (LT) patients who resume alcohol are at risk for a number of alcohol related problems including liver injury and liver failure. Post LT patients are strongly advised to remain abstinent. However, we don't know how well this population complies due to a lack of valid methods (self-report and/or biomarkers) to identify alcohol use. Studies suggest as many as 50% resume alcohol use within 5 years. Phosphatidylethanol (PEth) is a new cell-membrane phospholipid biomarker to identify alcohol use in the past 28 days...
February 14, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28179383/cultivated-limbal-epithelial-transplantation-and-penetrating-keratoplasty-postchemical-injury-a-14-year-follow-up
#4
Ritu Shah, Charuta Puranik, Ashik Mohamed, Virender S Sangwan
An 11-year-old girl presented to our tertiary eye care centre with a 9-month-old history of lime injury in the left eye in 1999 with vision of counting fingers close to the face. She initially underwent superficial keratectomy with amniotic membrane graft in 1999. Subsequently, cultivated limbal epithelial transplantation was performed in 2001 which improved her vision to 20/400. Following development of pannus and symblepharon in the left eye, she underwent pannus resection and conjunctival limbal autograft in 2002 and, a month later, optical penetrating keratoplasty (PK) following which her vision improved to 20/125...
February 8, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28174013/update-on-fertility-restoration-from-prepubertal-spermatogonial-stem-cells-how-far-are-we-from-clinical-practice
#5
Maria Grazia Giudice, Francesca de Michele, Jonathan Poels, Maxime Vermeulen, Christine Wyns
Fertility preservation in prepubertal boys facing gonadotoxic treatment is still at the experimental stage. Nevertheless cryopreservation of immature testicular tissue (ITT) obtained by small testicular biopsy is being increasingly proposed in reproductive care clinics for this purpose. Different approaches to in vivo or in vitro mature spermatogonial stem cells (SSCs) contained in ITT have been studied: autografting of testicular tissue pieces, transplantation of one's own purified germ cell suspensions, and in vitro maturation (IVM) for subsequent use of sperm for intra cytoplasmic sperm injection (ICSI)...
February 2, 2017: Stem Cell Research
https://www.readbyqxmd.com/read/28170177/pluripotent-nontumorigenic-adipose-tissue-derived-muse-cells-have-immunomodulatory-capacity-mediated-by-transforming-growth-factor-%C3%AE-1
#6
María L Gimeno, Florencia Fuertes, Andres E Barcala Tabarrozzi, Alejandra I Attorressi, Rodolfo Cucchiani, Luis Corrales, Talita C Oliveira, Mari C Sogayar, Leticia Labriola, Ricardo A Dewey, Marcelo J Perone
Adult mesenchymal stromal cell-based interventions have shown promising results in a broad range of diseases. However, their use has faced limited effectiveness owing to the low survival rates and susceptibility to environmental stress on transplantation. We describe the cellular and molecular characteristics of multilineage-differentiating stress-enduring (Muse) cells derived from adipose tissue (AT), a subpopulation of pluripotent stem cells isolated from human lipoaspirates. Muse-AT cells were efficiently obtained using a simple, fast, and affordable procedure, avoiding cell sorting and genetic manipulation methods...
January 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28163982/biomimetics-of-bone-implants-the-regenerative-road
#7
REVIEW
Elizabeth Brett, John Flacco, Charles Blackshear, Michael T Longaker, Derrick C Wan
The current strategies for healing bone defects are numerous and varied. At the core of each bone healing therapy is a biomimetic mechanism, which works to enhance bone growth. These range from porous scaffolds, bone mineral usage, collagen, and glycosaminoglycan substitutes to transplanted cell populations. Bone defects face a range of difficulty in their healing, given the composite of dense outer compact bone and blood-rich inner trabecular bone. As such, the tissue possesses a number of inherent characteristics, which may be clinically harnessed as promoters of bone healing...
2017: BioResearch Open Access
https://www.readbyqxmd.com/read/28162941/stem-cells-and-bronchopulmonary-dysplasia-the-five-questions-which-cells-when-in-which-dose-to-which-patients-via-which-route
#8
REVIEW
Martin Mueller, Boris W Kramer
Preterm birth is the leading cause of death in newborns and children. Despite advances in perinatology, immature infants continue to face serious risks such chronic respiratory impairment from bronchopulmonary dysplasia (BPD). Current treatment options are insufficient and novel approaches are desperately needed. In recent years stem cells have emerged as potential candidates to treat BPD with mesenchymal stem/stromal cells (MSCs) being particularly promising. MSCs originate from several stem cell niches including bone marrow, skin, or adipose, umbilical cord, and placental tissues...
December 24, 2016: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/28159115/william-hunter-harridge-lecture-the-changing-face-of-short-gut-syndrome-management
#9
REVIEW
John J Fung
The evolution of managing short gut syndrome optimizes management and decision making of intestinal failure by way of a multidisciplinary team utilizing the latest advances in therapeutic options. Only the minority of patients referred for small bowel transplantation will actually need a transplant. Many of these patients can be rehabilitated without the need for transplant, by way of early referral, and thus the likelihood of medical therapy increases. On the other hand, in those patients with little likelihood of success with medical therapy, early referral decreases the morbidity and mortality associated with long-term total parenteral nutrition and associated complications and will improve their overall survival outcomes...
January 25, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28153937/beliefs-and-attitudes-to-bowel-cancer-screening-in-patients-with-ckd-a-semistructured-interview-study
#10
Laura J James, Germaine Wong, Jonathan C Craig, Angela Ju, Narelle Williams, Wai H Lim, Nicholas Cross, Allison Tong
BACKGROUND AND OBJECTIVES: Bowel cancer is a leading cause of cancer-related death in people with CKD. Shared decision making regarding cancer screening is particularly complex in CKD and requires an understanding of patients' values and priorities, which remain largely unknown. Our study aimed to describe the beliefs and attitudes to bowel cancer screening in patients with CKD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Face to face, semistructured interviews were conducted from April of 2014 to December of 2015 with 38 participants ages 39-78 years old with CKD stages 3-5, on dialysis, or transplant recipients from four renal units in Australia and New Zealand...
February 2, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28149233/combination-of-medical-needling-and-non-cultured-autologous-skin-cell-transplantation-renovacell-for-repigmentation-of-hypopigmented-burn-scars-in-children-and-young-people
#11
K H Busch, R Bender, N Walezko, H Aziz, M A Altintas, M C Aust
Burn scars remain a serious physical and psychological problem for the affected. Clinical studies as well as basic scientific research have shown that Medical Needling can significantly increase the quality of burn scars with comparatively low risk and stress for the patient with regards to skin elasticity, moisture, erythema and transepidermal water loss. However, Medical Needling has no influence on repigmentation of large hypopigmented scars. The goal is to evaluate whether both established methods - Needling (improvement of scar quality) and ReNovaCell (repigmentation) - can be combined...
June 30, 2016: Annals of Burns and Fire Disasters
https://www.readbyqxmd.com/read/28144893/a-view-from-the-plateau-is-there-a-role-for-allogeneic-stem-cell-transplantation-in-the-era-of-highly-effective-therapies-for-multiple-myeloma
#12
REVIEW
Damian J Green, William I Bensinger
Allogeneic hematopoietic cell transplant (allo-HCT) represents the earliest form of immunotherapy used to treat multiple myeloma (MM). Since the first successful myeloablative allografts were performed in the early 1980s, highly effective new agents to treat this disease have been identified at an unprecedented pace. Currently, sixteen FDA-approved therapies are available to treat MM. As a consequence of these advances, the median overall survival for standard risk MM patients has extended to over 7 years...
January 31, 2017: Current Hematologic Malignancy Reports
https://www.readbyqxmd.com/read/28143863/perspectives-of-older-kidney-transplant-recipients-on-kidney-transplantation
#13
Jule Pinter, Camilla S Hanson, Jeremy R Chapman, Germaine Wong, Jonathan C Craig, Jane O Schell, Allison Tong
BACKGROUND AND OBJECTIVES: Older kidney transplant recipients are susceptible to cognitive impairment, frailty, comorbidities, immunosuppression-related complications, and chronic graft failure, however, there has been limited focus on their concerns and expectations related to transplantation. This study aims to describe the perspectives of older kidney transplant recipients about their experience of kidney transplantation, self-management, and treatment goals to inform strategies and interventions that address their specific needs...
January 31, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28141920/face-transplantation-partial-graft-loss-of-the-first-case-ten-years-later
#14
Emmanuel Morelon, Palmina Petruzzo, Jean Kanitakis, Stéphanie Dakpé, Olivier Thaunat, Valérie Dubois, Gabriel Choukroun, Sylvie Testelin, Jean-Michel Dubernard, Lionel Badet, Bernard Devauchelle
Ten years after the first face transplantation we report the partial loss of this graft. After two episodes of acute rejection (AR) occurred and completely reversed in the first post-transplantation year, ninety months post-transplantation the patient developed de novo class II-donor specific antibodies, without clinical signs of AR. Some months later she developed several skin rejection episodes treated with steroid pulses. Despite rapid clinical improvement, some months later the sentinel skin graft underwent necrosis...
January 31, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28138125/face-transplant-in-an-advanced-neurofibromatosis-type-1-patient
#15
Łukasz Krakowczyk, Adam Maciejewski, Cezary Szymczyk, Krzysztof Oleś, Stanisław Półtorak
BACKGROUND The human face is a one-of-a-kind structure with unique morphology, complexity, and function, in which different subunits are not even similar to other parts of the body. Therefore, extended complex deficits of the face are usually difficult to reconstruct, and autologous tissue restoration is generally not able to give a satisfactory aesthetic and functional outcome. The main goal of face allotransplantation is to restore symmetry, contour, and appearance as well as function of the face, especially control of orbicularis oculi and oris muscle physiology...
January 31, 2017: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/28133953/successful-renal-transplantation-in-small-children-with-a-completely-thrombosed-inferior-vena-cava
#16
P Verghese, E Minja, V Kirchner, B Chavers, A Matas, S Chinnakotla
In small children with end-stage renal disease, an adult-size kidney transplant is the best option. However, in the face of a completely thrombosed inferior vena cava (IVC), such transplants can be challenging, given the difficulty of achieving adequate renal venous outflow and the risk of graft thrombosis. Using a new technique to anastomose the renal vein to the right hepatic vein/IVC junction, we successfully implanted an adult-size graft in 2 small children (9.8 kg and 14 kg) who had end-stage renal disease and a completely thrombosed IVC...
January 30, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28128793/quality-of-life-and-functional-vision-in-children-treated-for-cataract-a-cross-sectional-study
#17
V K Tailor, Y Abou-Rayyah, J Brookes, P T Khaw, M Papadopoulos, G G W Adams, C Bunce, A Dahlmann-Noor
PurposeChildren with cataract and their families face intensive medical and surgical management, with numerous hospital attendances, topical medications, and surgical procedures, as well as uncertainty about the child's future visual ability, education, and independence. Little is known about the impact on functional visual ability, vision-, and health-related quality of life (VR-, HR-QoL).Patients and methodsSeventy two children aged 2-16 years (mean 8.45, SD 4.1) treated for developmental or secondary cataract and their parents/carers completed three validated instruments measuring functional visual ability, VR-, and HR-QoL: the Cardiff Visual Ability Questionnaire for Children (CVAQC), Impact of Vision Impairment for Children (IVI-C), and PedsQL V 4...
January 27, 2017: Eye
https://www.readbyqxmd.com/read/28128720/surgical-complications-after-pediatric-renal-transplant
#18
Hakan Sözen, Kibriya Fidan, Onur Özen, Oğuz Söylemezoğlu, Aydın Dalgıç
OBJECTIVES: Renal transplant is the most appropriate treatment for both adult and pediatric patients with end-stage renal failure. Here, we analyzed surgical complications after pediatric renal transplant at our center. MATERIALS AND METHODS: We retrospectively analyzed data from patient files and hospital charts of pediatric patients who had renal transplant at our center (Gazi University, Ankara, Turkey). Our immunosuppression protocol, a calcineurin inhibitor-based triple regimen, was applied to all recipients (steroids, mycophenolic acid)...
January 27, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28119426/family-strategies-to-support-siblings-of-pediatric-hematopoietic-stem-cell-transplant-patients
#19
Taylor E White, Kristopher A Hendershot, Margie D Dixon, Wendy Pelletier, Ann Haight, Kristin Stegenga, Melissa A Alderfer, Lydia Cox, Jeffrey M Switchenko, Pamela Hinds, Rebecca D Pentz
OBJECTIVE: To describe the strategies families report using to address the needs and concerns of siblings of children, adolescents, and young adults undergoing hematopoietic stem cell transplant (HSCT). METHODS: A secondary semantic analysis was conducted of 86 qualitative interviews with family members of children, adolescents, and young adults undergoing HSCT at 4 HSCT centers and supplemented with a primary analysis of 38 additional targeted qualitative interviews (23 family members, 15 health care professionals) conducted at the primary center...
January 24, 2017: Pediatrics
https://www.readbyqxmd.com/read/28117074/light-chain-cardiac-amyloidosis
#20
REVIEW
Anit K Mankad, Isata Sesay, Keyur B Shah
Cardiac amyloidosis is an underrecognized condition, in which delays to diagnosis have great implications on management options, prognosis, and morbidity. Once cardiac tissue is infiltrated by amyloid fibrils, there is a cascade of pathologic changes that can display an array of clinical manifestations, from impaired relaxation of the ventricular myocardium to severe restrictive disease or even progressive systolic heart failure. Management is guided not only by recognizing the subtype of amyloidosis (primary, hereditary, and wild-type transthyretin amyloidosis), but also the clinical stage of the disease...
November 17, 2016: Current Problems in Cancer
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