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https://www.readbyqxmd.com/read/29222969/copper-ii-complexes-of-n3o-tripodal-ligands-appended-with-pyrene-and-polyamine-groups-anti-proliferative-and-nuclease-activities
#1
Doti Serre, Sule Erbek, Nathalie Berthet, Xavier Ronot, Véronique Martel-Frachet, Fabrice Thomas
A series of tripodal ligands based on the 2-tert-butyl-4-R-6-phenol was synthesized, where R=aldehyde (HL1), R=putrescine-pyrene (HL2) and R=putrescine (HL3). A dinucleating ligand wherein a putrescine group connects two tripodal moieties was also prepared (H2L4). The corresponding copper complexes (1, 2, 3, and 4, respectively) were prepared and characterized. We determined the phenol's pKas in the range 2.47-3.93. The DNA binding constants were determined at 6×106, 5.5×105 and 2.7×106 for 2, 3 and 4, respectively...
November 11, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29222130/stargazin-and-cornichon-3-relieve-polyamine-block-of-ampa-receptors-by-enhancing-blocker-permeation
#2
Patricia M G E Brown, Hugo McGuire, Derek Bowie
Most ligand- and voltage-gated ion channels assemble as signaling complexes consisting of pore-forming and auxiliary subunits. In the mammalian brain, AMPA-type ionotropic glutamate receptors (AMPARs) coassemble with several families of auxiliary subunits that regulate channel gating as well as ion channel block and permeation. Previous work has shown that auxiliary proteins stargazin (or γ2) and cornichon-3 (CNIH-3) attenuate the cytoplasmic polyamine channel block of AMPARs, although the underlying mechanism has yet to be established...
December 8, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/29220165/photo-triggered-n2-generating-submicron-particles-for-selective-killing-of-cancer-cells
#3
Huiying Li, Wenbo Zhang, Ning He, Weijun Tong, Changyou Gao
Killing of cancer cells by applying mechanical disruption is an appealing emerging strategy for cancer treatment in recent years. In this study, photo-responsive submicron particles based on diazo-resin (DZR) which are able to release N2 under UV irradiation were prepared through a polyamine-salt aggregation method. After surface modification with hyaluronic acid (HA), the particles could be internalized selectively by cancer cells and mainly located in lysosomes after 6 h incubation. The viability of cancer cells decreased obviously after co-cultured with photo-responsive particles and UV irradiation due to the integrity damage of lysosomes by photo-triggered N2 generation and the subsequential increased reactive oxygen species...
December 8, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29219806/mucilaginibacter-amnicola-sp-nov-isolated-from-a-freshwater-creek
#4
Wen-Ming Chen, Tsai-Ying Hsieh, Shih-Yi Sheu
A pink-coloured bacterial strain, TAPP7T, was isolated from a freshwater creek in Taiwan. Phylogenetic analyses based on 16S rRNA gene sequences showed that strain TAPP7T belonged to the genus Mucilaginibacter and showed highest similarity with Mucilaginibacter ginsengisoli B4Y-8T (97.6 %) and Mucilaginibacter carri PR0008KT (96.9 %). Cells of strain TAPP7T were Gram-staining-negative, aerobic, poly-β-hydroxybutyrate-accumulating and short-rod-shaped. Growth occurred at 10-30 °C (optimum, 15-20 °C), at pH 4-8 (optimum, pH 6) and with 0-1 % NaCl (optimum, 0...
December 8, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/29216408/a-cold-responsive-erf-from-medicago-falcata-confers-cold-tolerance-by-up-regulation-of-polyamine-turnover-antioxidant-protection-and-proline-accumulation
#5
Chunliu Zhuo, Lu Liang, Yaqing Zhao, Zhenfei Guo, Shaoyun Lu
ERF subfamily transcription factors play an important role in plant abiotic and biotic stress tolerance. A cold responsive ethylene responsive factor (ERF), MfERF1, was isolated from Medicago falcata, an important forage legume that has great cold tolerance. Overexpression of MfERF1 resulted in an increased tolerance to freezing and chilling in transgenic tobacco plants, while down-regulation of the ortholog of MfERF1 in M. truncatula resulted in reduced freezing tolerance in RNAi plants. Higher transcript levels of some stress responsive genes (CHN50, OSM, ERD10C, and SAMS) and those involved in spermidine (Spd) and spermine (Spm) synthesis (SAMDC1, SAMDC2, SPDS1, SPDS2, and SPMS) and catabolism (PAO) were observed in transgenic plants than in WT...
December 7, 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/29215586/investigation-of-polyamine-metabolism-and-homeostasis-in-pancreatic-cancers
#6
Chelsea Massaro, Jenna Thomas, Otto Phanstiel Iv
Pancreatic cancers are currently the fourth leading cause of cancer-related death and new therapies are desperately needed. The most common pancreatic cancer is pancreatic ductal adenocarcinoma (PDAC). This report describes the development of therapies, which effectively deplete PDAC cells of their required polyamine growth factors. Of all human tissues, the pancreas has the highest level of the native polyamine spermidine. To sustain their high growth rates, PDACs have altered polyamine metabolism, which is reflected in their high intracellular polyamine levels and their upregulated import of exogenous polyamines...
December 7, 2017: Medical Sciences: Open Access Journal
https://www.readbyqxmd.com/read/29215193/metabolomics-of-tomato-xylem-sap-during-bacterial-wilt-reveals-ralstonia-solanacearum-produces-abundant-putrescine-a-metabolite-that-accelerates-wilt-disease
#7
Tiffany M Lowe-Power, Connor G Hendrich, Edda von Roepenack-Lahaye, Bin Li, Dousheng Wu, Raka Mitra, Beth L Dalsing, Patrizia Ricca, Jacinth Naidoo, David Cook, Amy Jancewicz, Patrick Masson, Bart Thomma, Thomas Lahaye, Anthony J Michael, Caitilyn Allen
Ralstonia solanacearum thrives in plant xylem vessels and causes bacterial wilt disease despite the low nutrient content of xylem sap. We found that R. solanacearum manipulates its host to increase nutrients in tomato xylem sap, enabling it to grow better in sap from infected plants than in sap from healthy plants. Untargeted GC/MS metabolomics identified 22 metabolites enriched in R. solanacearum-infected sap. Eight of these could serve as sole carbon or nitrogen sources for R. solanacearum. Putrescine, a polyamine that is not a sole carbon or nitrogen source for R...
December 7, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/29214424/itraq-based-comparative-proteomic-analysis-provides-insights-into-somatic-embryogenesis-in-gossypium-hirsutum-l
#8
Hua-Guo Zhu, Wen-Han Cheng, Wen-Gang Tian, Yang-Jun Li, Feng Liu, Fei Xue, Qian-Hao Zhu, Yu-Qiang Sun, Jie Sun
KEY MESSAGE: iTRAQ based proteomic identified key proteins and provided new insights into the molecular mechanisms underlying somatic embryogenesis in cotton. Somatic embryogenesis, which involves cell dedifferentiation and redifferentiation, has been used as a model system for understanding molecular events of plant embryo development in vitro. In this study, we performed comparative proteomics analysis using samples of non-embryogenic callus (NEC), embryogenic callus (EC) and somatic embryo (SE) using the isobaric tags for relative and absolute quantitation (iTRAQ) technology...
December 6, 2017: Plant Molecular Biology
https://www.readbyqxmd.com/read/29212086/comparative-analyses-of-transport-proteins-encoded-within-the-genomes-of-bdellovibrio-bacteriovorus-hd100-and-bdellovibrio-exovorus-jss
#9
Fereshteh Heidari Tajabadi, Arturo Medrano-Soto, Masoud Ahmadzadeh, Gholamreza Salehi Jouzani, Milton H Saier
Bdellovibrio, δ-proteobacteria, including B. bacteriovorus (Bba) and B. exovorus (Bex), are obligate predators of other Gram-negative bacteria. While Bba grows in the periplasm of the prey cell, Bex grows externally. We have analyzed and compared the transport proteins of these 2 organisms based on the current contents of the Transporter Classification Database (TCDB; www.tcdb.org). Bba has 103 transporters more than Bex, 50% more secondary carriers, and 3 times as many MFS carriers. Bba has far more metabolite transporters than Bex as expected from its larger genome, but there are 2 times more carbohydrate uptake and drug efflux systems, and 3 times more lipid transporters...
December 7, 2017: Journal of Molecular Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29208555/hollow-mesoporous-zirconia-delivery-system-for-biomineralization-precursors
#10
Xue-Qing Huang, Hong-Ye Yang, Tao Luo, Cui Huang, Franklin R Tay, Li-Na Niu
Strategies based on the combination of nanocarrier delivery systems and scaffolds provide bone tissue engineering scaffolds with multifunctional capability. Zirconia, a biocompatible ceramic commonly used in orthopedic and dental implants, was used to synthesize hollow mesoporous nanocapsules for loading, storage and sustained release of a novel polyamine-stabilized liquid precursor phase of amorphous calcium phosphate (PAH-ACP) for collagen biomineralization and bone marrow stromal cells osteoinduction. Hollow mesoporous zirconia (hmZrO2) nanocapsules loaded with biomimetic precursors exhibited pH-sensitive release capability and good biocompatibility...
December 2, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29205125/sphingopyxis-nepalensis-sp-nov-isolated-from-oil-contaminated-soil
#11
Dhiraj Kumar Chaudhary, Jaisoo Kim
During a study of oil-degrading bacteria, three yellow-coloured, Gram-stain-negative, non-motile and rod-shaped bacteria, designated strains Ktm-14T, Ktm-17 and Ktm-18, were isolated from oil-contaminated soil of Biratnagar, Morang, Nepal. The strains were able to grow at 15-37 °C, pH 4.5-10.0 and 0-2 % (w/v) NaCl concentration. Strains Ktm-14T, Ktm-17 and Ktm-18 were characterized by multiple taxonomic approaches. Based on 16S rRNA gene sequence analysis, strains Ktm-14T, Ktm-17 and Ktm-18 belonged to the genus Sphingopyxis and shared highest sequence similarity with Sphingopyxis ginsengisoliGsoil 250T (98...
December 5, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/29203548/utilization-of-host-polyamines-in-alternatively-activated-macrophages-promotes-chronic-infection-by-brucella-abortus
#12
Tobias Kerrinnes, Maria G Winter, Briana M Young, Vladimir E Diaz-Ochoa, Sebastian E Winter, Renée M Tsolis
Treatment of intracellular bacterial pathogens with antibiotic therapy often requires a long course of multiple antibiotics. A barrier to developing strategies that enhance antibiotic efficacy against these pathogens is our poor understanding of the intracellular nutritional environment that maintains bacterial persistence. The intracellular pathogen Brucella abortus survives and replicates preferentially in alternatively activated macrophages (AAM), however knowledge of the metabolic adaptations promoting exploitation of this niche is limited...
December 4, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/29196820/functional-roles-of-agmatinase-during-the-peri-implantation-period-of-pregnancy-in-sheep
#13
Yasser Y Lenis, Mohammed A Elmetwally, Wanjin Tang, Carey Satterfield, Kathrin Dunlap, Guoyao Wu, Fuller W Bazer
This study investigated the effect of agmatine (Agm) in proliferation of ovine trophecdoderm cells (oTr1) as well as the importance of the arginine decarboxylase (ADC) and agmatinase (AGMAT) alternative pathway for synthesis of polyamines in ovine conceptuses during the peri-implantation period of pregnancy. Morpholino antisense oligonucleotides (MAOs) were used to inhibit translation of mRNAs for ODC1 alone, AGMAT alone, and their combination. Rambouillet ewes (N = 50) were assigned randomly to the following treatments on Day 8 of pregnancy: MAO control (n = 10); MAO-ODC1 (n = 8); MAO-ADC (n = 6); MAO-ODC1:MAO-ADC (n = 9); or MAO-ODC1:MAO-AGMAT (n = 9)...
December 2, 2017: Amino Acids
https://www.readbyqxmd.com/read/29191942/%C3%AE-pix-plays-important-role-in-regulation-of-intestinal-epithelial-restitution-by-interacting-with-git1-and-rac1-after-wounding
#14
Navneeta Rathor, Hee Kyoung Chung, Shelley R Wang, Michael Qian, Douglas J Turner, Jian-Ying Wang, Jaladanki N Rao
Early gut mucosal restitution is a process by which intestinal epithelial cells (IECs) migrate over the wounded area, and its defective regulation occurs commonly in various critical pathological conditions. This rapid reepithelialization is mediated by different activating small GTP-binding proteins, but exact mechanism underlying this process remains largely unknown. Recently, it has been reported that interaction between p21-activated kinase-interacting exchange factor (β-PIX) and G-protein-coupled receptor kinase-interacting protein 1 (GIT1) activates small GTPases and plays important role in the regulation of cell motility...
November 30, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29191014/pyrrolidone-modification-prevents-pamam-dendrimers-from-activation-of-pro-inflammatory-signaling-pathways-in-human-monocytes
#15
Anna Janaszewska, Micha Gorzkiewicz, Mario Ficker, Johannes Fabritius Petersen, Valentina Paolucci, Jørn Bolstad Christensen, Barbara Klajnert-Maculewicz
BACKGROUND: The biological features of dendrimers are affected by the character of highly-reactive terminal moieties. In some polyamine dendrimer types the surface charge makes them bio-incompatible and prevent their direct medical application. Moreover, foreign particles can induce the immune response which is undesirable due to the adverse side effects in vivo. The reduction of cytotoxicity of positively charged macromolecules is possible through chemical modifications of terminal groups...
November 30, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29190951/multi-omics-analysis-reveals-that-ornithine-decarboxylase-contributes-to-erlotinib-resistance-in-pancreatic-cancer-cells
#16
Won-Jun Jang, Boyeon Choi, Sang-Hoon Song, Naeun Lee, Dong-Joon Kim, Sooyeun Lee, Chul-Ho Jeong
Molecular and metabolic alterations in cancer cells are one of the leading causes of acquired resistance to chemotherapeutics. In this study, we explored an experimental strategy to identify which of these alterations can induce erlotinib resistance in human pancreatic cancer. Using genetically matched erlotinib-sensitive (BxPC-3) and erlotinib-resistant (BxPC-3ER) pancreatic cancer cells, we conducted a multi-omics analysis of metabolomes and transcriptomes in these cells. Untargeted and targeted metabolomic analyses revealed significant changes in metabolic pathways involved in the regulation of polyamines, amino acids, and fatty acids...
November 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29190068/structural-and-functional-basis-for-targeting-campylobacter-jejuni-agmatine-deiminase-to-overcome-antibiotic-resistance
#17
Roger Shek, Devon A Dattmore, Devin P Stives, Ashley L Jackson, Christa H Chatfield, Katherine A Hicks, Jarrod B French
Campylobacter jejuni is the most common bacterial cause of gastroenteritis and a major contributor to infant mortality in the developing world. The increasing incidence of antibiotic-resistant C. jejuni only adds to the urgency to develop effective therapies. Because of the essential role that polyamines play, particularly in protection from oxidative stress, enzymes involved in the biosynthesis of these metabolites are emerging as promising antibiotic targets. The recent description of an alternative pathway for polyamine synthesis, distinct from that in human cells, in C...
November 30, 2017: Biochemistry
https://www.readbyqxmd.com/read/29189891/coralloluteibacterium-stylophorae-gen-nov-sp-nov-a-new-member-of-the-family-lysobacteraceae-isolated-from-the-reef-building-coral-stylophora-sp
#18
Wen-Ming Chen, Pei-Bei Xie, Sen-Lin Tang, Shih-Yi Sheu
A bacterial strain, designated Sty a-1T, was isolated from a reef-building coral Stylophora sp., collected off coast of Southern Taiwan and characterized using the polyphasic taxonomy approach. Cells of strain Sty a-1T were Gram-staining-negative, aerobic, poly-β-hydroxybutyrate accumulating, motile by means of flagella, non-spore forming, straight rod-shaped and colonies were yellow and circular. Growth occurred at 15-40 °C (optimum, 30-35 °C), at pH 6-10 (optimum, pH 6.5-8) and with 0-7% NaCl (optimum, 2-3%)...
November 30, 2017: Archives of Microbiology
https://www.readbyqxmd.com/read/29187844/speg-is-required-for-intracellular-replication-of-salmonella-in-various-human-cells-and-affects-its-polyamine-metabolism-and-global-transcriptomes
#19
Shiuh-Bin Fang, Ching-Jou Huang, Chih-Hung Huang, Ke-Chuan Wang, Nai-Wen Chang, Hung-Yin Pan, Hsu-Wei Fang, Ming-Te Huang, Ching-Kuo Chen
The speG gene has been reported to regulate polyamine metabolism in Escherichia coli and Shigella, but its role in Salmonella remains unknown. Our preliminary studies have revealed that speG widely affects the transcriptomes of infected in vitro M and Caco-2 cells and that it is required for the intracellular replication of Salmonella enterica serovar Typhimurium (S. Typhimurium) in HeLa cells. In this study, we demonstrated that speG plays a time-dependent and cell type-independent role in the intracellular replication of S...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29181726/the-inhibition-of-polyamine-biosynthesis-weakens-the-drought-tolerance-in-white-clover-trifolium-repens-associated-with-the-alteration-of-extensive-proteins
#20
Zhou Li, Yan Zhang, Dandan Peng, Yan Peng, Xinquan Zhang, Xiao Ma, Linkai Huang, Yanhong Yan
Changes of endogenous polyamine (PA) levels could be a key adaptive response to drought in plants. White clover pretreated with or without dicyclohexylamine (DCHA), an inhibitor of PA biosynthesis, was subjected to drought stress induced by 18% polyethylene glycol 6000 for 8 days in controlled growth chambers. Results showed that drought stress significantly increased endogenous PA content, whereas DCHA significantly decreased PA accumulation under drought stress. The attenuate PA biosynthesis was unfavorable for plant growth and drought tolerance, as reflected by significantly lower relative water content, relative growth rate, instantaneous water use efficiency, and cell membrane stability in leaves in response to drought...
November 28, 2017: Protoplasma
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