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https://www.readbyqxmd.com/read/29458098/spermine-protects-from-lps-induced-memory-deficit-via-bdnf-and-trkb-activation
#1
Pâmella K Frühauf-Perez, Fernanda R Temp, Micheli M Pillat, Cristiane Signor, Arithane Lorena Wendel, Henning Ulrich, Carlos F Mello, Maribel A Rubin
Lipopolysaccharide (LPS) has been long known to promote neuroinflammation and learning and memory deficits. Since spermine, one of the main natural polyamines in the central nervous system, protects from LPS-induced memory deficit by a mechanism that comprises GluN2B receptors, the aim of the present study was to determine whether brain-derived neurotrophic factor (BDNF), tropomyosin-related kinase B (TrkB) receptor and cAMP response element binding (CREB) are involved in this protective effect of spermine...
February 16, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29457726/a-robust-oil-in-oil-emulsion-for-the-nonaqueous-encapsulation-of-hydrophilic-payloads
#2
Xiaocun Lu, Joshua S Katz, Adam Schmitt, Jeffrey S Moore
Compartmentalized structures widely exist in cellular systems (organelles) and perform essential functions in smart composite materials (microcapsules, vasculatures, and micelles) to provide localized functionality and enhance materials compatibility. An entirely water-free compartmentalization system is of significant value to the materials community as nonaqueous conditions are critical to packaging microcapsules with water-free hydrophilic payloads while avoiding energy-intensive drying steps. Few nonaqueous encapsulation techniques are known, especially when considering just the scalable processes that operate in batch mode...
February 19, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29454986/nano-sized-tio-2-ntio-2-induces-metabolic-perturbations-in-physarum-polycephalum-macroplasmodium-to-counter-oxidative-stress-under-dark-conditions
#3
Zhi Zhang, Zhi Cheng Liang, Jian Hua Zhang, Sheng Li Tian, Jun Le Qu, Jiao Ning Tang, Shi De Liu
Nano-sized TiO2 (nTiO2 ) exerts an oxidative effect on cells upon exposure to solar or UV irradiation and ecotoxicity of the nTiO2 is an urgent concern. Little information is available regarding the effect of TiO2 on cells under dark conditions. Metabolomics is a unique approach to the discovery of biomarkers of nTiO2 cytotoxicity, and leads to the identification of perturbed metabolic pathways and the mechanism underlying nTiO2 toxicity. In the present study, gas chromatography mass spectrometry (GC/MS)-based metabolomics was performed to investigate the effect of nTiO2 on sensitive cells (P...
February 15, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29453849/methionine-is-required-for-camp-pka-mediated-morphogenesis-and-virulence-of-candida-albicans
#4
Sanne Schrevens, Griet Van Zeebroeck, Michael Riedelberger, Hélène Tournu, Karl Kuchler, Patrick Van Dijck
Candida albicans is a major human fungal pathogen, causing superficial, as well as life-threatening invasive infections. Therefore, it has to adequately sense and respond to the host defense by expressing appropriate virulence attributes. The most important virulence factor of C. albicans is the yeast-to-hyphae morphogenetic switch, which can be induced by numerous environmental cues, including the amino acid methionine. Here, we show an essential role for methionine permease Mup1 in methionine-induced morphogenesis, biofilm formation, survival inside macrophages and virulence...
February 17, 2018: Molecular Microbiology
https://www.readbyqxmd.com/read/29452772/metabolic-and-lipidomic-reprogramming-in-renal-cell-carcinoma-subtypes-reflects-regions-of-tumor-origin
#5
Elke Schaeffeler, Florian Büttner, Anna Reustle, Verena Klumpp, Stefan Winter, Steffen Rausch, Pascale Fisel, Jörg Hennenlotter, Stephan Kruck, Arnulf Stenzl, Judith Wahrheit, Denise Sonntag, Marcus Scharpf, Falko Fend, Abbas Agaimy, Arndt Hartmann, Jens Bedke, Matthias Schwab
BACKGROUND: Renal cell carcinoma (RCC) consists of prognostic distinct subtypes derived from different cells of origin (eg, clear cell RCC [ccRCC], papillary RCC [papRCC], and chromophobe RCC [chRCC]). ccRCC is characterized by lipid accumulation and metabolic alterations, whereas data on metabolic alterations in non-ccRCC are limited. OBJECTIVE: We assessed metabolic alterations and the lipid composition of RCC subtypes and ccRCC-derived metastases. Moreover, we elucidated the potential of metabolites/lipids for subtype classification and identification of therapeutic targets...
February 13, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29451723/clickable-polyamine-derivatives-as-chemical-probes-for-the-polyamine-transport-system
#6
Roeland Vanhoutte, Jan Pascal Kahler, Shaun Martin, Sarah van Veen, Steven Verhelst
Polyamines are essential for cell growth and differentiation, but their trafficking by the polyamine transport system is not fully understood. In this paper, we describe the synthesis of several azido-derivatized polyamines for easy conjugation by click chemistry. Attachment of a BODIPY-dye gave fluorescent polyamine probes, which were tested in cell culture. The linear probe series showed superior cellular uptake compared with the probes where the dye was attached to a branch on one of the central amines. Interestingly, the linear probes accumulated rapidly in cancer cells (MCF-7), but not in non-tumorigenic cells (MCF-10A)...
February 16, 2018: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/29450546/a-plasma-metabolomic-signature-of-the-exfoliation-syndrome-involves-amino-acids-acylcarnitines-and-polyamines
#7
Stéphanie Leruez, Thomas Bresson, Juan M Chao de la Barca, Alexandre Marill, Grégoire de Saint Martin, Adrien Buisset, Jeanne Muller, Lydie Tessier, Cédric Gadras, Christophe Verny, Patrizia Amati-Bonneau, Guy Lenaers, Philippe Gohier, Dominique Bonneau, Gilles Simard, Dan Milea, Vincent Procaccio, Pascal Reynier
Purpose: To determine the plasma metabolomic signature of the exfoliative syndrome (XFS), the most common cause worldwide of secondary open-angle glaucoma. Methods: We performed a targeted metabolomic study, using the standardized p180 Biocrates Absolute IDQ p180 kit with a QTRAP 5500 mass spectrometer, to compare the metabolomic profiles of plasma from individuals with XFS (n = 16), and an age- and sex-matched control group with cataract (n = 18). Results: A total of 151 metabolites were detected correctly, 16 of which allowed for construction of an OPLS-DA model with a good predictive capability (Q2cum = 0...
February 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29449779/-saccharomyces-boulardii-cncm-i-745-improves-intestinal-enzyme-function-a-trophic-effects-review
#8
REVIEW
Margret I Moré, Yvan Vandenplas
Several properties of the probiotic medicinal yeast Saccharomyces boulardii CNCM I-745 contribute to its efficacy to prevent or treat diarrhoea. Besides immunologic effects, pathogen-binding and anti-toxin effects, as well as positive effects on the microbiota, S boulardii CNCM I-745 also has pronounced effects on digestive enzymes of the brush border membrane, known as trophic effects. The latter are the focus of this review. Literature has been reviewed after searching Medline and PMC databases. All relevant non-clinical and clinical studies are summarized...
2018: Clinical Medicine Insights. Gastroenterology
https://www.readbyqxmd.com/read/29445227/novel-ubiquitin-independent-nucleolar-c-myc-degradation-pathway-mediated-by-antizyme-2
#9
Noriyuki Murai, Yasuko Murakami, Ayasa Tajima, Senya Matsufuji
The proto-oncogene c-Myc encodes a short-lived protein c-Myc that regulates various cellular processes including cell growth, differentiation and apoptosis. Degradation of c-Myc is catalyzed by the proteasome and requires phosphorylation of Thr-58 for ubiquitination by E3 ubiquitin ligase, Fbxw7/ FBW7. Here we show that a polyamine regulatory protein, antizyme 2 (AZ2), interacts with c-Myc in the nucleus and nucleolus, to accelerate proteasome-mediated c-Myc degradation without ubiquitination or Thr-58 phosphorylation...
February 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29444615/the-mysterious-polyamines-the-enigmatic-barr-body-and-lupus-comment-on-the-article-by-kim-et-al
#10
W Brooks
"Polyamine patterns in plasma of patients with systemic lupus erythematosus and fever" by Kim et al. provides insight into possible involvement of polyamines in systemic lupus erythematosus (SLE). The authors report decreases in N1-acetylspermidine, spermidine, spermine, and N1-acetylcadaverine and increased cadaverine in SLE. Polyamine involvement in many cellular processes and their unique characteristics (high charge, length, flexibility, and ubiquity) give polyamines importance in health and disease...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29436980/virtual-screening-of-natural-inhibitors-targeting-ornithine-decarboxylase-with-pharmacophore-scaffolding-of-dfmo-and-validation-by-molecular-dynamics-simulation-studies
#11
Sivashanmugam Muthukumaran, K N Sulochana, V Umashankar
Ornithine Decarboxylase (ODC) is an enzyme that initiates polyamine synthesis in human. Polyamines play key roles in cell-cell adhesion, cell motility and Cell cycle regulation. Higher synthesis of polyamines also occurs in rapidly proliferating cancer cells are mediated by ODC. As per earlier studies, Di-Flouro Methyl Orninthine (DFMO) is a proven efficient inhibitor ODC targeting the catalytic activity, however, its usage is limited due to side effects. Targeting ODC is considered as a potential therapeutic modality in the treatment of cancer...
February 13, 2018: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29435126/quantitative-metabolomics-for-investigating-the-value-of-polyamines-in-the-early-diagnosis-and-therapy-of-colorectal-cancer
#12
Ran Liu, Xiaohui Lin, Zuojing Li, Qing Li, Kaishun Bi
As an important biomarker for cancer, polyamine levels in body fluid could be employed for monitoring the colorectal cancer (CRC), however the role of polyamines in the development and therapeutics phases of CRC remains uncertain. In this paper, the relationship between polyamines and CRC development and therapeutics had been investigated by the study of changes in plasma polyamine levels during the precancerous, developmental and treatment phases of CRC. After inducing CRC in Wistar rats by intraperitoneal injection of 1, 2-dimethylhydrazine, the animals were given a traditional Chinese medicine, Aidi injections...
January 12, 2018: Oncotarget
https://www.readbyqxmd.com/read/29432194/structurally-modulated-codelivery-of-sirna-and-argonaute-2-for-enhanced-rna-interference
#13
Jiahe Li, Connie Wu, Wade Wang, Yanpu He, Elad Elkayam, Leemor Joshua-Tor, Paula T Hammond
Small interfering RNA (siRNA) represents a promising class of inhibitors in both fundamental research and the clinic. Numerous delivery vehicles have been developed to facilitate siRNA delivery. Nevertheless, achieving highly potent RNA interference (RNAi) toward clinical translation requires efficient formation of RNA-induced gene-silencing complex (RISC) in the cytoplasm. Here we coencapsulate siRNA and the central RNAi effector protein Argonaute 2 (Ago2) via different delivery carriers as a platform to augment RNAi...
February 5, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29431900/deciphering-drought-induced-metabolic-responses-and-regulation-in-developing-maize-kernels
#14
Liming Yang, Jake C Fountain, Pingsheng Ji, Xinzhi Ni, Sixue Chen, Robert D Lee, Robert C Kemerait, Baozhu Guo
Drought stress conditions decrease maize growth and yield, and aggravate pre-harvest aflatoxin contamination. While several studies have been performed on mature kernels responding to drought stress, the metabolic profiles of developing kernels are not as well characterized, particularly in germplasm with contrasting resistance to both drought and mycotoxin contamination. Here, following screening for drought tolerance, a drought-sensitive line, B73, and a drought-tolerant line, Lo964, were selected and stressed beginning at 14 days after pollination...
February 12, 2018: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/29428908/molecular-cloning-and-expression-analysis-of-the-tyramine-br-receptor-genes-in-apis-cerana-cerana
#15
Li-Zhen Zhang, Yong Zhang, Jing-Hua Hu, Zi-Long Wang, Zhi-Jiang Zeng
Tyramine is a biological polyamine, which serves important functions as neurotransmitters, neuromodulators and neurohormone of the central nervous system. It participates in the regulation of various behavior and physiological processes in insects. For example, tyramine and its receptor genes are involved in the regulation of learning and memory in the animals. In this study, the full-length cDNA sequences of the tyramine receptor genes (Actyr1 and Actyr2) of the Chinese honeybee, Apis cerana cerana, were cloned and sequenced for the first time...
February 20, 2018: Yi Chuan, Hereditas
https://www.readbyqxmd.com/read/29421567/targeting-polyamine-transport-in-trypanosoma-cruzi
#16
Chantal Reigada, Otto Phanstiel, Mariana R Miranda, Claudio A Pereira
Polyamines play critical roles as regulators of cell growth and differentiation. In contrast with other protozoa, the human parasite Trypanosoma cruzi, the etiological agent of Chagas disease, is auxotrophic for polyamines. Therefore, their intracellular availability depends exclusively on polyamine transport and inhibition of these uptake processes can alter the viability of the parasite. The polyamine analogues used in this work were successfully tested as antiproliferative agents in cancer cells, bacteria, fungi and also showed a potent antiplasmodial effect...
January 31, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29419804/alpha-difluoromethylornithine-an-irreversible-inhibitor-of-polyamine-biosynthesis-as-a-therapeutic-strategy-against-hyperproliferative-and-infectious-diseases
#17
REVIEW
Nicole LoGiudice, Linh Le, Irene Abuan, Yvette Leizorek, Sigrid C Roberts
The fluorinated ornithine analog α-difluoromethylornithine (DFMO, eflornithine, ornidyl) is an irreversible suicide inhibitor of ornithine decarboxylase (ODC), the first and rate-limiting enzyme of polyamine biosynthesis. The ubiquitous and essential polyamines have many functions, but are primarily important for rapidly proliferating cells. Thus, ODC is potentially a drug target for any disease state where rapid growth is a key process leading to pathology. The compound was originally discovered as an anticancer drug, but its effectiveness was disappointing...
February 8, 2018: Medical Sciences: Open Access Journal
https://www.readbyqxmd.com/read/29415460/the-plant-defensin-nad1-enters-the-cytoplasm-of-candida-albicans-via-endocytosis
#18
Brigitte M E Hayes, Mark R Bleackley, Marilyn A Anderson, Nicole L van der Weerden
Antimicrobial peptides are widespread in nature and are produced by many organisms as a first line of defence against pathogens. These peptides have a broad range of biological activities, such as antibacterial or antifungal activities and act with varied mechanisms of action. A large number of the peptides are amphipathic α-helices which act by disrupting plasma membranes and allowing leakage of intracellular contents. However, some peptides have more complex mechanisms of action that require internalisation into the target organisms' cytoplasm...
February 6, 2018: Journal of Fungi (Basel, Switzerland)
https://www.readbyqxmd.com/read/29414728/biophysical-characterization-of-the-dna-interaction-with-the-biogenic-polyamine-putrescine-a%C3%A2-single-molecule-study
#19
B C Publio, T A Moura, C H M Lima, M S Rocha
We have performed a biophysical characterization, at single molecule level, of the interaction between the DNA molecule and the biogenic polyamine putrescine. By using force spectroscopy, we were able to monitor the complexes formation as putrescine is added to the sample, determining the mechanical properties of such complexes and the physicochemical (binding) parameters of the interaction for three different ionic strengths. In particular, it was shown that the behavior of the equilibrium binding constant as a function of the counterion concentration deviates from the prediction of the Record-Lohman model...
January 31, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29413679/assessment-of-the-quality-of-refrigerated-and-frozen-pork-by-multivariate-exploratory-techniques
#20
Flávia Beatriz Custódio, Milton C Vasconcelos-Neto, Karine H Theodoro, Renan Campos Chisté, Maria Beatriz A Gloria
Pork loin and leg were evaluated 24h after slaughter and during refrigerated (5°C) and frozen storage for microbial counts, pH, total volatile base nitrogen (TVB-N), thiobarbituric acid reactive substances (TBARS) and bioactive amines. Spermine was the prevalent amine in fresh pork loin and leg, followed by spermidine and agmatine. During refrigerated storage, pH, TVB-N, mesophilic and psychrotrophic counts increased and no changes (p<0.05) were observed on polyamines; however putrescine, cadaverine and histamine were produced and accumulated throughout storage...
January 10, 2018: Meat Science
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