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https://www.readbyqxmd.com/read/28822266/endogenous-non-enzymatic-antioxidants-in-the-human-body
#1
Iwona Mirończuk-Chodakowska, Anna Maria Witkowska, Małgorzata Elżbieta Zujko
The exposure of cells, tissues and extracellular matrix to harmful reactive species causes a cascade of reactions and induces activation of multiple internal defence mechanisms (enzymatic or non-enzymatic) that provide removal of reactive species and their derivatives. The non-enzymatic antioxidants are represented by molecules characterized by the ability to rapidly inactivate radicals and oxidants. This paper focuses on the major intrinsic non-enzymatic antioxidants, including metal binding proteins (MBPs), glutathione (GSH), uric acid (UA), melatonin (MEL), bilirubin (BIL) and polyamines (PAs)...
August 16, 2017: Advances in Medical Sciences
https://www.readbyqxmd.com/read/28820116/sphingobium-naphthae-sp-nov-with-the-ability-to-degrade-aliphatic-hydrocarbons-isolated-from-oil-contaminated-soil
#2
Dhiraj Kumar Chaudhary, Seung-Woo Jeong, Jaisoo Kim
A light yellow-coloured, Gram-stain-negative, non-motile and rod-shaped bacterium, designated strain K-3-6T, capable of degrading aliphatic hydrocarbons was isolated from oil-contaminated soil of Biratnagar, Morang, Nepal. It was able to grow at 15-45 °C, at pH 5.0-9.5 and with 0-6 % (w/v) NaCl. Based on 16S rRNA gene sequence analysis, strain K-3-6T belongs to the genus Sphingobium and is closely related to Sphingobium olei IMMIB HF-1T (98.4 % similarity), Sphingobium abikonense NBRC 16140T (98.3 %), Sphingobium rhizovicinum CC-FH12-1T (97...
August 18, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28820106/sphingomonas-gotjawalisoli-sp-nov-isolated-from-soil-of-a-lava-forest
#3
Keun Chul Lee, Kwang Kyu Kim, Mi Kyung Eom, Jong-Shik Kim, Dae-Shin Kim, Suk-Hyung Ko, Seung-Hoon Yang, Jung-Sook Lee
A bacterial strain, designated SN6-9T, was isolated from soil of the Gotjawal, lava forest, located in Jeju, Republic of Korea. Strain SN6-9T was Gram-stain-negative, motile, oxidase- and catalase-negative, yellow-pigmented and rod-shaped. It contained summed feature 3 (C16 : 1ω7c and/or C16 : 1ω6c) and summed feature 8 (C18 : 1ω7c and/or C18 : 1ω6c) as the major fatty acids, Q-10 as the predominant isoprenoid quinone, sym-homospermidine as the major polyamine and diphosphatidylglycerol, phosphatidylglycerol, phosphatidylethanolamine, phosphatidylcholine, sphingoglycolipid and two unidentified phospholipids as the polar lipids...
August 18, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28820099/hymenobacter-pallidus-sp-nov-isolated-from-a-freshwater-fish-culture-pond
#4
Shih-Yi Sheu, Yi-Shu Li, Chiu-Chung Young, Wen-Ming Chen
A bacterial strain designated LYH-12T was isolated from a freshwater fish culture pond in Taiwan, ROC and characterized by taking a polyphasic taxonomy approach. Phylogenetic analyses based on 16S rRNA gene sequences showed that strain LYH-12T belonged to the genus Hymenobacter and was most closely related to Hymenobacter xinjiangensis X2-1gT and Hymenobacter rigui WPCB131T with a sequence similarity of 96.6 % and less than 96.5 % with other members of the genus. Cells of strain LYH-12T were Gram-stain-negative, aerobic, non-motile rods that were covered by large capsules and formed light pink-coloured colonies...
August 18, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28820094/massilia-solisilvae-sp-nov-massilia-terrae-sp-nov-and-massilia-agilis-sp-nov-isolated-from-forest-soil-in-south-korea-by-using-a-newly-developed-culture-method
#5
Khulan Altankhuu, Jaisoo Kim
Using a newly developed culture method for not yet cultured soil bacteria, three Gram-stain-negative, aerobic, non-spore-forming, motile, and rod-shaped bacteria (strain designated J18T, J11T and J9T) were isolated from forest soil at Kyonggi University, South Korea. Isolates were subjected to a taxonomic study by using a polyphasic approach. According to a phylogenetic tree based on 16S rRNA gene sequences, strains J18T, J11T and J9T belonged to the genus Massilia and clustered with Massilia haematophila CCUG 38318T (similarity range: 97...
August 18, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28820093/sphingomonas-limnosediminicola-sp-nov-and-sphingomonas-palustris-sp-nov-isolated-from-freshwater-environments
#6
Ji Hee Lee, Dae In Kim, Han Na Choe, Soon Dong Lee, Chi Nam Seong
Two aerobic, Gram-stain-negative, gliding and yellow-pigmented bacteria, designated strains 03SUJ6T and WM95T were isolated from freshwater sediment of Juam reservoir and freshwater of Woopo wetland, Republic of Korea, respectively. Cells of the two strains are motile by gliding and catalase- and oxidase-positive. The 16S rRNA gene sequence similarity between 03SUJ6T and WM95T was 97.7 %, but their DNA-DNA relatedness was 55.1 %. A maximum-likelihood phylogenetic tree based on 16S rRNA gene sequences showed that 03SUJ6T and WM95T each form independent lineages within the genus Sphingomonas...
August 18, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28819816/a-new-non-radioactive-deoxyhypusine-synthase-assay-adaptable-to-high-throughput-screening
#7
Myung Hee Park, Ajeet Mandal, Swati Mandal, Edith C Wolff
Deoxyhypusine synthase (DHS) catalyzes the post-translational modification of eukaryotic translation factor 5A (eIF5A) by the polyamine, spermidine, that converts one specific lysine residue to deoxyhypusine [N (ε) -4-aminobutyl(lysine)], which is subsequently hydroxylated to hypusine [N (ε) -4-amino-2-hydroxybutyl(lysine)]. Hypusine synthesis represents the most critical function of polyamine. As eIF5A has been implicated in various human diseases, identification of specific inhibitors of hypusine modification is of vital importance...
August 17, 2017: Amino Acids
https://www.readbyqxmd.com/read/28817100/modulatory-effects-of-exogenously-applied-polyamines-on-postharvest-physiology-antioxidant-system-and-shelf-life-of-fruits-a-review
#8
REVIEW
Sunil Sharma, Sunil Pareek, Narashans Alok Sagar, Daniel Valero, Maria Serrano
Polyamines (PAs) are natural compounds involved in many growth and developmental processes in plants, and, specifically in fruits, play a vital role regulating its development, ripening and senescence processes. Putrescine (PUT), spermine (SPE), and spermidine (SPD) are prominent PAs applied exogenously to extend shelf life of fruits. They also originate endogenously during developmental phases of horticultural crops and simultaneously affect the quality attributes and shelf life. Their anti-ethylene nature is being exploited to enhance the shelf life when exogenously applied on fruits...
August 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28815856/molecular-dynamics-insights-into-polyamine-dna-binding-modes-implications-for-cross-link-selectivity
#9
Emmanuelle Bignon, Chen-Hui Chan, Christophe Morell, Antonio Monari, Jean-Luc Ravanat, Elise Dumont
Biogenic polyamines, which play a role in DNA condensation and stabilization, are ubiquitous and are found at millimolar concentration in the nucleus of eukaryotic cells. The interaction modes of three polyamines-putrescine (Put), spermine (Spm), and spermidine (Spd)-with a self-complementary 16 base pair (bp) duplex, are investigated by all-atom explicit-solvent molecular dynamics. The length of the amine aliphatic chain leads to a change of the interaction mode from minor groove binding to major groove binding...
August 16, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28809153/lacihabitans-lacunae-sp-nov-isolated-from-a-lagoon
#10
Heeyoung Kang, Haneul Kim, Jaeho Song, Jang-Cheon Cho, Kiseong Joh, Yochan Joung
A non-motile, orange-pigmented bacterium, designated strain HME7103T, was isolated from lagoon water in the Republic of Korea. A phylogenetic tree based on 16S rRNA gene sequences showed that strain HME7103T formed a lineage within the genus Lacihabitans and family Cytophagaceae. Strain HME7103T was closely related to Lacihabitans soyangensis HME6675T (95.7 % 16S rRNA gene sequence similarity). The major fatty acids of strain HME7103T were summed feature 3 (comprising C16 : 1ω7c and/or C16 : 1ω6c) and iso-C15 : 0...
August 15, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28807600/methylglyoxal-synthase-regulates-cell-elongation-via-alterations-of-cellular-methylglyoxal-and-spermidine-content-in-bacillus-subtilis
#11
Sang-Min Shin, Sung-Hyun Song, Jin-Woo Lee, Min-Kyu Kwak, Sa-Ouk Kang
Methylglyoxal regulates cell division and differentiation through its interaction with polyamines. Loss of their biosynthesizing enzyme causes physiological impairment and cell elongation in eukaryotes. However, the reciprocal effects of methylglyoxal and polyamine production and its regulatory metabolic switches on morphological changes in prokaryotes have not been addressed. Here, Bacillus subtilis methylglyoxal synthase (mgsA) and polyamine biosynthesizing genes encoding arginine decarboxylase (SpeA), agmatinase (SpeB), and spermidine synthase (SpeE), were disrupted or overexpressed...
August 11, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/28807574/synthesis-and-evaluation-of-analogs-of-5-z-4-amino-2-butenyl-methylamino-5-deoxyadenosine-mdl-73811-or-abeado-an-inhibitor-of-s-adenosylmethionine-decarboxylase-with-antitrypanosomal-activity
#12
Anthony J Brockway, Oleg A Volkov, Casey C Cosner, Karen S MacMillan, Stephen A Wring, Thomas E Richardson, Michael Peel, Margaret A Phillips, Jef K De Brabander
We describe our efforts to improve the pharmacokinetic properties of a mechanism-based suicide inhibitor of the polyamine biosynthetic enzyme S-adenosylmethionine decarboxylase (AdoMetDC), essential for the survival of the eukaryotic parasite Trypanosoma brucei responsible for Human African Trypanosomiasis (HAT). The lead compound, 5'-(((Z)-4-amino-2-butenyl)methylamino)-5'-deoxyadenosine (1, also known as MDL 73811, or AbeAdo), has curative efficacy at a low dosage in a hemolymphatic model of HAT but displayed no demonstrable effect in a mouse model of the CNS stage of HAT due to poor blood-brain barrier permeation...
August 3, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28803869/metabolic-flexibility-underpins-growth-capabilities-of-the-fastest-growing-alga
#13
Haim Treves, Omer Murik, Isaac Kedem, Doron Eisenstadt, Sagit Meir, Ilana Rogachev, Jedrzej Szymanski, Nir Keren, Isabel Orf, Antonio F Tiburcio, Rubén Alcázar, Asaph Aharoni, Joachim Kopka, Aaron Kaplan
The factors rate-limiting growth of photosynthetic organisms under optimal conditions are controversial [1-8]. Adaptation to extreme environments is usually accompanied by reduced performance under optimal conditions [9, 10]. However, the green alga Chlorella ohadii, isolated from a harsh desert biological soil crust [11-17], does not obey this rule. In addition to resistance to photodamage [17, 18], it performs the fastest growth ever reported for photosynthetic eukaryotes. A multiphasic growth pattern (very fast growth [phase I], followed by growth retardation [phase II] and additional fast growth [phase III]) observed under constant illumination and temperature indicates synchronization of the algal population...
August 3, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28802268/ornithine-decarboxylase-mediated-production-of-putrescine-influences-ganoderic-acid-biosynthesis-by-regulating-ros-in-ganoderma-lucidum
#14
Chen-Gao Wu, Jia-Long Tian, Rui Liu, Peng-Fei Cao, Tian-Jun Zhang, Ang Ren, Liang Shi, Ming-Wen Zhao
Putrescine is an important polyamine that participates in a variety of stress responses. Ornithine decarboxylase (ODC) is a key enzyme that catalyzes the biosynthesis of putrescine. A homolog of the gene encoding ODC was cloned from Ganoderma lucidum In the ODC-silenced strains, the transcript levels of the ODC gene and the putrescine content were significantly decreased. The ODC-silenced strains were more sensitive to oxidative stress. The content of ganoderic acid was increased by approximately 43-46% in the ODC-silenced strains...
August 11, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28799668/ligand-influence-on-the-carbonyl-hydroboration-catalysis-by-alkali-metal-hydridotriphenylborates-l-m-hbph3-m-li-na-k
#15
Jun Okuda, Thomas Spaniol, Hassan Osseili, Debabrata Mukherjee
Alkali metal hydridotriphenylborates [(L1)M][HBPh3] (L1 = Me6TREN; M = Li, Na, K) chemoselectively catalyze the hydroboration of carbonyls and CO2, with lithium being the most active system. A new series of complexes [(L2)M][HBPh3] [M = Li (1), Na (2), K (3)] with the cyclen-derived macrocyclic polyamine Me4TACD (L2) were synthesized in a 'one-pot' fashion and fully characterized including X-ray crystallography. In the crystal, 1-3 exhibit wide variation in metal coordination of the [HBPh3] anion from lithium to potassium...
August 11, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28798743/l-arginine-uptake-by-cationic-amino-acid-transporter-promotes-intra-macrophage-survival-of-leishmania-donovani-by-enhancing-arginase-mediated-polyamine-synthesis
#16
Abhishek Mandal, Sushmita Das, Ajay Kumar, Saptarshi Roy, Sudha Verma, Ayan Kumar Ghosh, Ruby Singh, Kumar Abhishek, Savita Saini, Abul Hasan Sardar, Bidyut Purkait, Ashish Kumar, Chitra Mandal, Pradeep Das
The survival of intracellular protozoan parasite, Leishmania donovani, the causative agent of Indian visceral leishmaniasis (VL), depends on the activation status of macrophages. l-Arginine, a semi-essential amino acid plays a crucial regulatory role for activation of macrophages. However, the role of l-arginine transport in VL still remains elusive. In this study, we demonstrated that intra-macrophage survival of L. donovani depends on the availability of extracellular l-arginine. Infection of THP-1-derived macrophage/human monocyte-derived macrophage (hMDM) with Leishmania, resulted in upregulation of l-arginine transport...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28792375/sphingomonas-olei-sp-nov-with-the-ability-to-degrade-aliphatic-hydrocarbons-isolated-from-oil-contaminated-soil
#17
Dhiraj Kumar Chaudhary, Jaisoo Kim
A yellow-coloured, Gram-stain-negative, non-motile, rod-shaped bacterium, designated K-1-16T, that is capable of degrading aliphatic hydrocarbons was isolated from oil-contaminated soil at Biratnagar, Morang, Nepal. It was able to grow at 15-45 °C, at pH 5.5-9.5 and with 0-5 % (w/v) NaCl. This strain was taxonomically characterized by a polyphasic approach. Based on 16S rRNA gene sequence analysis, strain K-1-16T belongs to the genus Sphingomonas and is closely related to Sphingomonas mucosissima CP173-2T (98...
August 10, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28791767/the-delivery-of-doxorubicin-of-multifunctional-%C3%AE-cyclodextrin-modified-cdse-zns-quantum-dots-for-bioactivity-and-nano-probing
#18
Mei-Xia Zhao, Bing-Jie Zhu, Wen-Jing Yao, Di-Feng Chen, Chaojie Wang
The modified quantum dots (QDs), have been used in intracellular probing and drug delivery because of their special chemical and physical properties. In this paper, two β-cyclodextrin (β-CD)-modified CdSe/ZnS QDs with strong optical emission properties were synthesized as drug carriers to induce apoptosis. The positively charged L-Arginine (L-Arg) and neutral L-Tryptophan (L-Trp) were selected as ligands to compare the effect of charge on bioactivity of QDs nanoparticles. The in vitro assays revealed that these modified QDs showed good Dox carrier ability and significantly high inhibition rate to cancer cells...
August 9, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28789897/functionalization-of-peptide-nucleolipid-bioconjugates-and-their-structure-anti-cancer-activity-relationship-studies
#19
Niki Rana, Christopher Cultrara, Mariana Phillips, David Sabatino
In the search for more potent peptide-based anti-cancer conjugates the generation of new, functionally diverse nucleolipid derived D-(KLAKLAK)2-AK sequences has enabled a structure and anti-cancer activity relationship study. A reductive amination approach was key for the synthesis of alkylamine, diamine and polyamine derived nucleolipids as well as those incorporating heterocyclic functionality. The carboxy-derived nucleolipids were then coupled to the C-terminus of the D-(KLAKLAK)2-AK killer peptide sequence and produced with and without the FITC fluorophore for investigating biological activity in cancer cells...
July 26, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28782053/elucidating-the-structure-of-n-1-acetylisoputreanine-a-novel-polyamine-catabolite-in-human-urine
#20
Bryna L Fitzgerald, Sebabrata Mahapatra, Delphine K Farmer, Michael R McNeil, Robert A Casero, John T Belisle
An untargeted metabolomics approach was utilized to determine urinary metabolites that could serve as small-molecule biomarkers for treatment response to standard tuberculosis treatment. However, the majority of metabolites that most accurately distinguished patient samples at the time of diagnosis from those at 1 month after the start of therapy lacked structural identification. The detection of unknown metabolite structures is a well-known limitation of untargeted metabolomics and underscores a need for continued elucidation of novel metabolite structures...
July 31, 2017: ACS Omega
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