keyword
MENU ▼
Read by QxMD icon Read
search

Polyamine

keyword
https://www.readbyqxmd.com/read/28520822/correction-biochemical-evaluation-of-the-anticancer-potential-of-the-polyamine-based-nanocarrier-nano11047
#1
Tracy Murray-Stewart, Elena Ferrari, Ying Xie, Fei Yu, Laurence J Marton, David Oupicky, Robert A Casero
[This corrects the article DOI: 10.1371/journal.pone.0175917.].
2017: PloS One
https://www.readbyqxmd.com/read/28517002/modulation-of-the-fe-ii-spin-crossover-effect-in-the-pentadecanuclear-fe9-m-cn-8-6-m-re-w-clusters-by-facial-coordination-of-tridentate-polyamine-ligands
#2
Szymon Chorazy, Jan J Stanek, Jedrzej Kobylarczyk, Shin-Ichi Ohkoshi, Barbara Sieklucka, Robert Podgajny
Spin crossover (SCO) materials, revealing the externally tunable transition between two different spin states, arouse great scientific interest due to their perspective application in information storage, display devices and sensing. Of special importance are the molecular systems offering the possibility of multimodal switching within many spin centers. This is achievable in polynuclear clusters consisting of several SCO-active complexes, however, such molecules are very rare. Herein, we report a unique pair of nanometric pentadecanuclear {Fe9[M(CN)8]6(Me3tacn)8}·14MeOH (Me3tacn = 1,4,7-trimethyl-1,4,7-triazacyclononane, M = Re, 1; M = W, 2) clusters exhibiting a thermally induced spin crossover effect on Fe(ii) complexes, that is on both central and external Fe sites embedded in the cyanido-bridged cluster core...
May 18, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28516954/histone-deacetylase-10-structure-and-molecular-function-as-a-polyamine-deacetylase
#3
Yang Hai, Stephen A Shinsky, Nicholas J Porter, David W Christianson
Cationic polyamines such as spermidine and spermine are critical in all forms of life, as they regulate the function of biological macromolecules. Intracellular polyamine metabolism is regulated by reversible acetylation and dysregulated polyamine metabolism is associated with neoplastic diseases such as colon cancer, prostate cancer and neuroblastoma. Here we report that histone deacetylase 10 (HDAC10) is a robust polyamine deacetylase, using recombinant enzymes from Homo sapiens (human) and Danio rerio (zebrafish)...
May 18, 2017: Nature Communications
https://www.readbyqxmd.com/read/28510212/supercoiling-biases-the-formation-of-loops-involved-in-gene-regulation
#4
REVIEW
Laura Finzi, David Dunlap
The function of DNA as a repository of genetic information is well-known. The post-genomic effort is to understand how this information-containing filament is chaperoned to manage its compaction and topological states. Indeed, the activities of enzymes that transcribe, replicate, or repair DNA are regulated to a large degree by access. Proteins that act at a distance along the filament by binding at one site and contacting another site, perhaps as part of a bigger complex, create loops that constitute topological domains and influence regulation...
November 2016: Biophysical Reviews
https://www.readbyqxmd.com/read/28509362/developing-polyamine-based-peptide-amphiphiles-with-tunable-morphology-and-physicochemical-properties
#5
Mehdi Bin Samad, Yashpal Singh Chhonker, Jacob I Contreras, Alec McCarthy, Megan M McClanahan, Daryl J Murry, Martin Conda-Sheridan
The ability to tune supramolecular properties such as size, morphology, or metabolic stability is of paramount importance in the field of supramolecular chemistry. Peptide amphiphiles (PAs) are a family of functional self-assembling biomaterials that have garnered widespread attention due to their broad applicability in medicine. PAs are generally comprised of an amino acid sequence connected to lipid tail(s) allowing them to self-assemble into supramolecular structures with diverse morphologies. Herein, this study describes the synthesis of a new class of polyamine-based "hybrid" PAs (PPAs) as novel self-assembling systems...
May 16, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/28508929/untargeted-metabolomic-analysis-of-tomato-pollen-development-and-heat-stress-response
#6
Marine J Paupière, Florian Müller, Hanjing Li, Ivo Rieu, Yury M Tikunov, Richard G F Visser, Arnaud G Bovy
Pollen development metabolomics. Developing pollen is among the plant structures most sensitive to high temperatures, and a decrease in pollen viability is often associated with an alteration of metabolite content. Most of the metabolic studies of pollen have focused on a specific group of compounds, which limits the identification of physiologically important metabolites. To get a better insight into pollen development and the pollen heat stress response, we used a liquid chromatography-mass spectrometry platform to detect secondary metabolites in pollen of tomato (Solanum lycopersicum L...
May 16, 2017: Plant Reproduction
https://www.readbyqxmd.com/read/28504844/naphthalimide-based-polyammonium-chemosensors-for-anions-study-of-binding-properties-and-sensing-mechanisms
#7
Aleksandr S Oshchepkov, Ramana R Mittapalli, Olga A Fedorova, Evgeny A Kataev
New naphthalimide-based receptors for anions have been synthesized. Efficient synthetic routes have been found to functionalize the naphthalimide core with branched polyamines. Binding and sensing properties of the receptors have been studied by potentiometric, NMR and fluorescence titrations. The receptors bind selectively the pyrophosphate anion in buffered aqueous solutions. The receptors with more than six amine groups in the structure have demonstrated the highest affinities for pyrophosphate. The fluorescence response towards anions have been found to be dependent on the position of the amine groups relative to the naphthalimide core and on the pH of the buffered solution...
May 15, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28502202/cooking-processes-increase-bioactive-compounds-in-organic-and-conventional-green-beans
#8
Giuseppina Pace Pereira Lima, Sergio Marques Costa, Kamila de Almeida Monaco, Maira Rodrigues Uliana, Roberto Morato Fernandez, Camila Renata Correa, Fabio Vianello, Luis Cisneros-Zevallos, Igor Otavio Minatel
The influence of cooking methods on chlorophyl, carotenoids, polyamines, polyphenols contents and antioxidant capacity were analyzed in organic and conventional green beans. The initial raw material had a higher content of chlorophyl and total phenolics in conventional green beans, whereas organic cultive favored flavonoid content and antioxidant capacity. Polyamines and carotenoids were similar for the two crop systems. After the cooking process, carotenoids (β-carotene, lutein and zeaxanthin) increased. Microwave heating favored the enhancement of some polar compounds, whereas pressure cooking favored carotenoids...
May 15, 2017: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/28498653/recovering-rare-earth-elements-from-aqueous-solution-with-porous-amine-epoxy-networks
#9
Walter Christopher Wilfong, Brian W Kail, Tracy L Bank, Bret H Howard, McMahan L Gray
Recovering aqueous rare earth elements (REEs) from domestic water sources is one key strategy to diminish the U.S.'s foreign reliance of these precious commodities. Herein, we synthesized an array of porous, amine-epoxy monolith and particle REE recovery sorbents from different polyamine, namely tetraethylenepentamine, and diepoxide (E2), triepoxide (E3), and tetra-epoxide (E4) monomer combinations via a polymer-induced phase separation (PIPS) method. The polyamines provided -NH2 (primary amine) plus -NH (secondary amine) REE adsorption sites, which were partially reacted with C-O-C (epoxide) groups at different amine/epoxide ratios to precipitate porous materials that exhibited a wide range of apparent porosities and REE recoveries/affinities...
May 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28498360/meristem-plant-cells-as-a-sustainable-source-of-redox-actives-for-skin-rejuvenation
#10
REVIEW
Liudmila G Korkina, Wolfgang Mayer, Chiara de Luca
Recently, aggressive advertisement claimed a "magic role" for plant stem cells in human skin rejuvenation. This review aims to shed light on the scientific background suggesting feasibility of using plant cells as a basis of anti-age cosmetics. When meristem cell cultures obtained from medicinal plants are exposed to appropriate elicitors/stressors (ultraviolet, ultrasound ultraviolet (UV), ultrasonic waves, microbial/insect metabolites, heavy metals, organic toxins, nutrient deprivation, etc.), a protective/adaptive response initiates the biosynthesis of secondary metabolites...
May 12, 2017: Biomolecules
https://www.readbyqxmd.com/read/28498338/synthesis-biological-activity-and-preliminary-in-silico-admet-screening-of-polyamine-conjugates-with-bicyclic-systems
#11
Marta Szumilak, Malgorzata Galdyszynska, Kamila Dominska, Irena I Bak-Sypien, Anna Merecz-Sadowska, Andrzej Stanczak, Boleslaw T Karwowski, Agnieszka W Piastowska-Ciesielska
Polyamine conjugates with bicyclic terminal groups including quinazoline, naphthalene, quinoline, coumarine and indole have been obtained and their cytotoxic activity against PC-3, DU-145 and MCF-7 cell lines was evaluated in vitro. Their antiproliferative potential differed markedly and depended on both their chemical structure and the type of cancer cell line. Noncovalent DNA-binding properties of the most active compounds have been examined using ds-DNA thermal melting studies and topo I activity assay. The promising biological activity, DNA intercalative binding mode and favorable drug-like properties of bis(naphthalene-2-carboxamides) make them a good lead for further development of potential anticancer drugs...
May 12, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28489025/plasticizing-effects-of-polyamines-in-protein-based-films
#12
Mohammed Sabbah, Prospero Di Pierro, C Valeria L Giosafatto, Marilena Esposito, Loredana Mariniello, Carlos Regalado-Gonzales, Raffaele Porta
Zeta potential and nanoparticle size were determined on film forming solutions of native and heat-denatured proteins of bitter vetch as a function of pH and of different concentrations of the polyamines spermidine and spermine, both in the absence and presence of the plasticizer glycerol. Our results showed that both polyamines decreased the negative zeta potential of all samples under pH 8.0 as a consequence of their ionic interaction with proteins. At the same time, they enhanced the dimension of nanoparticles under pH 8...
May 10, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28487688/gamma-glutamylpolyamine-synthetase-glna3-is-involved-in-the-first-step-of-polyamine-degradation-pathway-in-streptomyces-coelicolor-m145
#13
Sergii Krysenko, Nicole Okoniewski, Andreas Kulik, Arne Matthews, Jan Grimpo, Wolfgang Wohlleben, Agnieszka Bera
Streptomyces coelicolor M145 was shown to be able to grow in the presence of high concentrations of polyamines, such as putrescine, cadaverine, spermidine, or spermine, as a sole nitrogen source. However, hardly anything is known about polyamine utilization and its regulation in streptomycetes. In this study, we demonstrated that only one of the three proteins annotated as glutamine synthetase-like protein, GlnA3 (SCO6962), was involved in the catabolism of polyamines. Transcriptional analysis revealed that the expression of glnA3 was strongly induced by exogenous polyamines and repressed in the presence of ammonium...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28484432/rice-bran-and-probiotics-alter-the-porcine-large-intestine-and-serum-metabolomes-for-protection-against-human-rotavirus-diarrhea
#14
Nora Jean Nealon, Lijuan Yuan, Xingdong Yang, Elizabeth P Ryan
Human rotavirus (HRV) is a leading cause of severe childhood diarrhea, and there is limited vaccine efficacy in the developing world. Neonatal gnotobiotic pigs consuming a prophylactic synbiotic combination of probiotics and rice bran (Pro+RB) did not exhibit HRV diarrhea after challenge. Multiple immune, gut barrier protective, and anti-diarrheal mechanisms contributed to the prophylactic efficacy of Pro+RB when compared to probiotics (Pro) alone. In order to understand the molecular signature associated with diarrheal protection by Pro+RB, a global non-targeted metabolomics approach was applied to investigate the large intestinal contents and serum of neonatal gnotobiotic pigs...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28480991/unraveling-the-multistimuli-responses-of-a-complex-dynamic-system-of-pseudopeptidic-macrocycles
#15
Angel M Valdivielso, Francesc Puig-Castellví, Joan Atcher, Jordi Solà, Romà Tauler, Ignacio Alfonso
Dynamic combinatorial libraries (DCLs) are excellent benchmark models to study the stimuli-responsiveness of chemical networks. However, increasingly complex systems are difficult to analyze with simple data analysis methods, because many variables and connections must be considered for their full understanding. Here we propose the use of multivariate data analysis methods to bisect the evolution of a complex synthetic dynamic library of pseudopeptidic macrocycles, containing side chains with charges of different sign...
May 8, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28480742/read-across-of-ready-biodegradability-based-on-the-substrate-specificity-of-n-alkyl-polypropylene-polyamine-degrading-microorganisms
#16
R Geerts, C G van Ginkel, C M Plugge
The biodegradation of N-alkyl polypropylene polyamines (NAPPs) was studied using pure and mixed cultures to enable read-across of ready biodegradability test results. Two Pseudomonas spp. were isolated from activated sludge with N-oleyl alkyl propylene diamine and N-coco alkyl dipropylene triamine, respectively. Both strains utilized all NAPPs tested as the sole source of carbon, nitrogen and energy for growth. Mineralization of NAPPs was independent of the alkyl chain length and the size of the polyamine moiety...
May 8, 2017: SAR and QSAR in Environmental Research
https://www.readbyqxmd.com/read/28478810/atractylenolide-i-stimulates-intestinal-epithelial-repair-through-polyamine-mediated-ca-2-signaling-pathway
#17
Hou-Pan Song, Xue-Qin Hou, Ru-Yi Li, Rong Yu, Xin Li, Sai-Nan Zhou, Hui-Yong Huang, Xiong Cai, Chi Zhou
BACKGROUND: An impairment of the integrity of the mucosal epithelial barrier can be observed in the course of various gastrointestinal diseases. The migration and proliferation of the intestinal epithelial (IEC-6) cells are essential repair modalities to the healing of mucosal ulcers and wounds. Atractylenolide I (AT-I), one of the major bioactive components in the rhizome of Atractylodes macrocephala Koidz. (AMR), possesses multiple pharmacological activities. This study was designed to investigate the therapeutic effects and the underlying molecular mechanisms of AT-I on gastrointestinal mucosal injury...
May 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28467636/an-exercise-in-brain-genoarchitectonics-analysis-of-azin2-lacz-expressing-neuronal-populations-in-the-mouse-hindbrain
#18
Margaret Martinez-de-la-Torre, Ana Lambertos, Rafael Peñafiel, Luis Puelles
We examined in detail the distribution of AZIN2 (antizyme inhibitor 2) expression in the adult mouse hindbrain and neighboring spinal cord. AZIN2, similar to previously known AZIN1, is a recently-discovered, a functional paralog of ornithine decarboxylase (ODC). Due to their structural similarity to ODC, both AZIN1 and AZIN2 counteract the inhibitory action of 3 known antizymes (AZ1-3) on the ODC synthesis of polyamines, thus increasing intracytoplasmic levels of polyamines. AZIN2 is strongly, but heterogeneously, expressed in the brain...
May 3, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/28466893/zinc-hydridotriphenylborates-supported-by-a-neutral-macrocyclic-polyamine
#19
Debabrata Mukherjee, Ann-Kristin Wiegand, Thomas P Spaniol, Jun Okuda
The zinc hydridotriphenylborates [(L)Zn(TMDS)][HBPh3] and [(L)ZnX][HBPh3] (L = Me4TACD, Me4[12]aneN4; TMDS = N(SiHMe2)2; X = Cl, Br, I) were synthesized by BPh3-mediated β-SiH abstraction and salt metathesis with KHBPh3, respectively. CO2 is rapidly inserted into the B-H bonds. [(L)Zn(TMDS)][HBPh3] catalyzes the hydroboration of polar substrates including CO2.
May 16, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28463938/hemorrhagic-shock-and-tissue-injury-drive-distinct-plasma-metabolome-derangements-in-swine
#20
Nathan Clendenen, Geoffrey R Nunns, Ernest E Moore, Julie A Reisz, Eduardo Gonzalez, Erik Peltz, Christopher C Silliman, Miguel Fragoso, Travis Nemkov, Matthew J Wither, Kirk Hansen, Anirban Banerjee, Hunter B Moore, Angelo DʼAlessandro
BACKGROUND: Tissue injury and hemorrhagic shock induce significant systemic metabolic reprogramming in animal models and critically injured patients. Recent expansions of the classic concepts of metabolomic aberrations in tissue injury and hemorrhage opened the way for novel resuscitative interventions based on the observed abnormal metabolic demands. We hypothesize that metabolic demands and resulting metabolic signatures in pig plasma will vary in response to isolated or combined tissue injury and hemorrhagic shock...
May 1, 2017: Journal of Trauma and Acute Care Surgery
keyword
keyword
32729
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"