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https://www.readbyqxmd.com/read/28220901/distinct-signatures-of-dental-plaque-metabolic-byproducts-dictated-by-periodontal-inflammatory-status
#1
Akito Sakanaka, Masae Kuboniwa, Ei Hashino, Takeshi Bamba, Eiichiro Fukusaki, Atsuo Amano
Onset of chronic periodontitis is associated with an aberrant polymicrobial community, termed dysbiosis. Findings regarding its etiology obtained using high-throughput sequencing technique suggested that dysbiosis holds a conserved metabolic signature as an emergent property. The purpose of this study was to identify robust biomarkers for periodontal inflammation severity. Furthermore, we investigated disease-associated metabolic signatures of periodontal microbiota using a salivary metabolomics approach. Whole saliva samples were obtained from adult subjects before and after removal of supragingival plaque (debridement)...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28220137/proteomic-analysis-reveals-the-positive-effect-of-exogenous-spermidine-in-tomato-seedlings-response-to-high-temperature-stress
#2
Qinqin Sang, Xi Shan, Yahong An, Sheng Shu, Jin Sun, Shirong Guo
Polyamines are phytohormones that regulate plant growth and development as well as the response to environmental stresses. To evaluate their functions in high-temperature stress responses, the effects of exogenous spermidine (Spd) were determined in tomato leaves using two-dimensional electrophoresis and MALDI-TOF/TOF MS. A total of 67 differentially expressed proteins were identified in response to high-temperature stress and/or exogenous Spd, which were grouped into different categories according to biological processes...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28214225/a-relay-pathway-between-arginine-and-tryptophan-metabolism-confers-immunosuppressive-properties-on-dendritic-cells
#3
Giada Mondanelli, Roberta Bianchi, Maria Teresa Pallotta, Ciriana Orabona, Elisa Albini, Alberta Iacono, Maria Laura Belladonna, Carmine Vacca, Francesca Fallarino, Antonio Macchiarulo, Stefano Ugel, Vincenzo Bronte, Federica Gevi, Lello Zolla, Auke Verhaar, Maikel Peppelenbosch, Emilia Maria Cristina Mazza, Silvio Bicciato, Yasmina Laouar, Laura Santambrogio, Paolo Puccetti, Claudia Volpi, Ursula Grohmann
Arginase 1 (Arg1) and indoleamine 2,3-dioxygenase 1 (IDO1) are immunoregulatory enzymes catalyzing the degradation of l-arginine and l-tryptophan, respectively, resulting in local amino acid deprivation. In addition, unlike Arg1, IDO1 is also endowed with non-enzymatic signaling activity in dendritic cells (DCs). Despite considerable knowledge of their individual biology, no integrated functions of Arg1 and IDO1 have been reported yet. We found that IDO1 phosphorylation and consequent activation of IDO1 signaling in DCs was strictly dependent on prior expression of Arg1 and Arg1-dependent production of polyamines...
February 13, 2017: Immunity
https://www.readbyqxmd.com/read/28212867/protective-effect-of-spermine-against-pentylenetetrazole-kindling-epilepsy-induced-comorbidities-in-mice
#4
Mandeep Kumar, Puneet Kumar
Nitric oxide (NO), an important intracellular signaling molecule is involved in modulation of neuronal transmission. The NO level increases during epileptic activity in animal models of epilepsy. However, its role in epileptic activity remains controversial. Spermine is an endogenous polyamine; possesses anti-oxidant property and has ability to modulate ion channels and NO synthase activity. Therefore, the present study was designed to investigate the role of NO pathway in the neuroprotective effect of spermine, in Pentylenetetrazol (PTZ) induced kindling epilepsy in mice...
February 14, 2017: Neuroscience Research
https://www.readbyqxmd.com/read/28211620/benchmark-ditopic-binding-of-cl-and-cs-by-the-macrocycle-hexacyclen
#5
Juan Ramon Aviles-Moreno, Giel Berden, Jos Oomens, Bruno Martinez-Haya
The ditopic binding of organic and inorganic anions and cations constitutes a distinct feature of polyazamacrocycles that underlies their action as intermediate docking and exchange ionophoric sites for tailored supramolecular synthesis and sensors. This work investigates the Cl- and Cs+ complexes formed by hexacyclen (1,4,7,10,13,16-hexaazacyclooctadecane, ha18c6), a benchmark building block of ion-pair polyamine receptors. Infrared action spectroscopy is employed to characterize the anionic and cationic complexes under controlled environmental conditions in an ion trap...
February 17, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28211312/olivibacter-composti-sp-nov-isolated-from-compost-collected-at-a-greenhouse
#6
Shih-Yao Lin, Asif Hameed, Kai-Yeh Chiu, You-Cheng Liu, Yi-Han Hsu, Wei-An Lai, Chiu-Chung Young
A polyphasic approach was used to characterize a presumably novel bacterium, designated strain CC-KYC063T, isolated from a compost sample collected at a greenhouse facility within Taiwan. Strain CC-KYC063T was Gram-stain-negative and aerobic, able to grow at 15-37 °C (optimal 30 °C), at pH 7.0-9.0 (optimal pH 7.0) and with 0-2 % (w/v) NaCl. The 16S rRNA gene sequence of strain CC-KYC063T showed highest similarity to Olivibacter ginsengisoli Gsoil 060T (96.2 %) and Olivibacter terrae Jip13T (95.5 %)...
January 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28211309/chryseobacterium-reticulitermitis-sp-nov-isolated-from-the-gut-of-reticulitermes-aculabialis
#7
Yun Zhao, Yu Wang, Dan Hong Li, Yu Deng, Hong Yang
A Gram-staining-negative, non-motile, aerobic and rod-shaped bacterium, strain Ra1T, was isolated from the gut of a wood-feeding lower termite, Reticulitermes aculabialis. Phylogenetic analysis of 16S rRNA gene sequences showed that the strain was closely related to Chryseobacterium rigui JCM 18078T (96.7%). Growth was observed at 15-45℃ (optimum 30℃), at pH 6.0-9.0 (optimum pH 8.0) and in the presence of 0-2% NaCl (optimum 0%). The DNA G+C content of strain Ra1T was 39.9 mol%. The cells contained MK-6 as the sole respiratory quinone and the major fatty acids were iso-C15:0, iso-C17:0, summed feature 3 (comprising C16:1ω6c and/or C16:1ω7c) and summed feature 9 (comprising C16:0 10-methyl and/or iso-C17:1ω9c)...
February 2, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28205404/macrocyclic-triamine-derived-glucose-analogues-for-99m-tc-co-3-labeling-synthesis-and-biological-evaluation-as-potential-tumor-imaging-agents
#8
Teli Liu, Qianqian Gan, Junbo Zhang
[(99m) Tc(CO)3 (H2 O)3 ](+) has attracted great attention among (99m) Tc-labeling techniques, due to its ease of preparation, readily substituted water molecules of the precursor fac-[(99m) Tc(CO)3 (H2 O)3 ](+) by a variety of functional groups, small size and inertness. Bifunctional chelator based on a macrocyclic polyamine framework shows easy complexation with [(99m) Tc(CO)3 (H2 O)3 ](+) to produce stable complex. In this study, two novel 1, 5, 9-triazacyclododecane derivatives containing a glucose group (6 and 7) were successfully synthesized by reacting different glucose-azides with alkyne-[12]aneN3 via the so-called click chemistry and radiolabeled with [(99m) Tc(CO)3 (H2 O)3 ](+) to form (99m) Tc(CO)3 -6 (C-1-substituted complex) and (99m) Tc(CO)3 -7 (C-2-substituted complex) in high yields...
February 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28202352/amino-acid-transporter-slc38a3-promotes-metastasis-of-non-small-cell-lung-cancer-cells-by-activating-pdk1
#9
Yanhui Wang, Li Fu, Minqing Cui, Yongbin Wang, Yan Xu, Molin Li, Jun Mi
BACKGROUND: Tumor metastasis is a finely-tuned pathological process coupled to metabolic reprogramming that includes both glutamine and glucose. The solute carrier SLC38A3, a member of amino acid/polyamine/organocation (APC) superfamily, is an L-glutamine transporter. It is not clear whether SLC38A3 involves the metastasis of NSCLC (non small cell lung cancer). METHODS: The scratch test and transwell assay were used to determine the ability of NSCLC to migrate. Cellular amino acids content was determined by mass spectrometry...
February 12, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28201987/an-integrative-metabolomics-and-transcriptomics-study-to-identify-metabolic-alterations-in-aged-skin-of-humans-in-vivo
#10
Andreas Kuehne, Janosch Hildebrand, Joern Soehle, Horst Wenck, Lara Terstegen, Stefan Gallinat, Anja Knott, Marc Winnefeld, Nicola Zamboni
BACKGROUND: Aging human skin undergoes significant morphological and functional changes such as wrinkle formation, reduced wound healing capacity, and altered epidermal barrier function. Besides known age-related alterations like DNA-methylation changes, metabolic adaptations have been recently linked to impaired skin function in elder humans. Understanding of these metabolic adaptations in aged skin is of special interest to devise topical treatments that potentially reverse or alleviate age-dependent skin deterioration and the occurrence of skin disorders...
February 15, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28199662/the-arabidopsis-polyamine-oxidase-dehydrogenase-5-interferes-with-cytokinin-and-auxin-signaling-pathways-to-control-xylem-differentiation
#11
Osama Alabdallah, Abdellah Ahou, Namrata Mancuso, Valerio Pompili, Alberto Macone, Dimitre Pashkoulov, Pasquale Stano, Alessandra Cona, Riccardo Angelini, Paraskevi Tavladoraki
No abstract text is available yet for this article.
February 8, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28188858/analysis-of-the-in-vitro-and-in-vivo-effects-of-photodynamic-therapy-on-prostate-cancer-by-using-new-photosensitizers-protoporphyrin-ix-polyamine-derivatives
#12
Chloë Fidanzi-Dugas, Bertrand Liagre, Guillaume Chemin, Aurélie Perraud, Claire Carrion, Claude-Yves Couquet, Robert Granet, Vincent Sol, David Yannick Léger
BACKGROUND: Photodynamic therapy, using porphyrins as photosensitizers (PS), has been approved in treatment of several solid tumors. However, commonly used PS induce death but also resistance pathways in cancer cells and an alteration of surrounding normal tissues. Because polyamines (PA) are actively accumulated in cancer cells by the Polyamine Transport System (PTS), they may enable PS to specifically target cancer cells. Here, we investigated whether new protoporphyrin IX-polyamine derivatives were effective PS against prostate cancer and whether PA increased PDT specificity after red light irradiation...
February 7, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28182119/biodegradable-mesoporous-delivery-system-for-biomineralization-precursors
#13
Hong-Ye Yang, Li-Na Niu, Jin-Long Sun, Xue-Qing Huang, Dan-Dan Pei, Cui Huang, Franklin R Tay
Scaffold supplements such as nanoparticles, components of the extracellular matrix, or growth factors have been incorporated in conventional scaffold materials to produce smart scaffolds for tissue engineering of damaged hard tissues. Due to increasing concerns on the clinical side effects of using large doses of recombinant bone-morphogenetic protein-2 in bone surgery, it is desirable to develop an alternative nanoscale scaffold supplement that is not only osteoinductive, but is also multifunctional in that it can perform other significant bone regenerative roles apart from stimulation of osteogenic differentiation...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28179101/molecular-phylogenomic-study-and-the-role-of-exogenous-spermidine-in-the-metabolic-adjustment-of-endogenous-polyamine-in-two-rice-cultivars-under-salt-stress
#14
Jayita Saha, Kalyan Giri
Compelling evidences anticipated the well acclamation of involvement of exogenous and endogenous polyamines (PAs) in conferring salt tolerance in plants. Intracellular PA's anabolism and catabolism should have contributed to maintain endogenous PAs homeostasis to induce stress signal networks. In this report, the evolutionary study has been conducted to reveal the phylogenetic relationship of genes encoding enzymes of the anabolic and catabolic pathway of PAs among the five plant lineages including green algae, moss, lycophyte, dicot and monocot along with their respective exon-intron structural patterns...
April 20, 2017: Gene
https://www.readbyqxmd.com/read/28178573/enhancement-of-cold-and-salt-tolerance-of-arabidopsis-by-transgenic-expression-of-the-s-adenosylmethionine-decarboxylase-gene-from-leymus-chinensis
#15
Zhujiang Liu, Panpan Liu, Dongmei Qi, Xianjun Peng, Gongshe Liu
Leymus chinensis is an important perennial forage grass natively distributed in the Eurasian Steppe. However, little is known about the molecular mechanism of its adaptation to extreme environmental conditions. Based on L. chinensis cold-treated sequence database, a highly expressed S-adenosylmethionine decarboxylase gene (LcSAMDC1) was isolated from L. chinensis. Gene structure analysis showed that LcSAMDC1 has two introns and three exons as well as three non-overlapping ORFs in its mRNA sequence. One hour of cold exposure caused a significant up-regulation of LcSAMDC1, while abscisic acid (ABA), salt, and osmotic stresses slightly induced its expression...
January 19, 2017: Journal of Plant Physiology
https://www.readbyqxmd.com/read/28177238/design-synthesis-and-biological-evaluation-of-mitochondria-targeted-flavone-naphthalimide-polyamine-conjugates-with-antimetastatic-activity
#16
Fujun Dai, Qian Li, Yuxia Wang, Chaochao Ge, Chenyang Feng, Songqiang Xie, Haoying He, Xiaojuan Xu, Chaojie Wang
Approximately 90% of cancer-associated deaths result from disseminated tumors, indicating the ineffectiveness of current therapies and the imperative need of antimetastatic drugs. A novel pharmacophore with flavonoid and naphthalimide moieties was constructed by using a fragment-based drug design and a series of eight flavone-naphthalimide-polyamine conjugates were synthesized. In vitro evaluation revealed that compound 6c with a homospermidine motif displayed better cell selectivity between cancerous and normal liver cells than amonafide did...
February 8, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28176540/antitumoral-activity-of-1-2-diaminocyclohexane-derivatives-in-breast-colon-and-skin-human-cancer-cells
#17
Fátima Morales, Alberto Ramírez, Cynthia Morata-Tarifa, Saúl A Navarro, Juan A Marchal, Joaquín M Campos, Ana Conejo-García
AIM: Cancer is among the leading causes of death worldwide. Medical interest has focused on macrocyclic polyamines because of their properties as antitumor agents. Results/Methodology: We have designed and synthesized a series of 1,2-diaminocyclohexane derivatives with notable in vitro antiproliferative activities against the MCF-7, HCT-116 and A375 cancer cell lines. Cell cycle and apoptosis analyses were also carried out. Our results show that all the compounds are potent cytotoxic agents, especially against the A375 cell line...
February 8, 2017: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/28175909/elucidation-of-the-polyamine-biosynthesis-pathway-during-brazilian-pine-araucaria-angustifolia-seed-development
#18
Leandro F de Oliveira, Paula Elbl, Bruno V Navarro, Amanda F Macedo, André L W Dos Santos, Eny I S Floh, Janice Cooke
No abstract text is available yet for this article.
January 31, 2017: Tree Physiology
https://www.readbyqxmd.com/read/28174575/editorial-molecular-mechanisms-underlying-polyamine-functions-in-plants
#19
EDITORIAL
Patrick H Masson, Taku Takahashi, Riccardo Angelini
No abstract text is available yet for this article.
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28172475/integrated-metabolomics-and-proteomics-highlight-altered-nicotinamide-and-polyamine-pathways-in-lung-adenocarcinoma
#20
Johannes F Fahrmann, Dmitry Grapov, Kwanjeera Wanichthanarak, Brian C DeFelice, Michelle R Salemi, William N Rom, David R Gandara, Brett S Phinney, Oliver Fiehn, Harvey Pass, Suzanne Miyamoto
No abstract text is available yet for this article.
January 3, 2017: Carcinogenesis
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