Luca Mazzarella, Fabio Santoro, Roberto Ravasio, Valeria Fumagalli, Paul E Massa, Simona Rodighiero, Elena Gavilán, Mauro Romanenghi, Bruno A Duso, Emanuele Bonetti, Lara Manganaro, Rani Pallavi, Deborah Trastulli, Isabella Pallavicini, Claudia Gentile, Silvia Monzani, Tommaso Leonardi, Sebastiano Pasqualato, Gabriele Buttinelli, Angela Di Martino, Giorgio Fedele, Ilaria Schiavoni, Paola Stefanelli, Giuseppe Meroni, Raffaele de Francesco, Christian Steinkuhler, Gianluca Fossati, Matteo Iannacone, Saverio Minucci, Pier Giuseppe Pelicci
Innate immune responses to coronavirus infections are highly cell specific. Tissue-resident macrophages, which are infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in patients but are inconsistently infected in vitro, exert critical but conflicting effects by secreting both antiviral type I interferons (IFNs) and tissue-damaging inflammatory cytokines. Steroids, the only class of host-targeting drugs approved for the treatment of coronavirus disease 2019 (COVID-19), indiscriminately suppress both responses, possibly impairing viral clearance...
December 19, 2023: Science Signaling